@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu07080: (2016-06-11 )
MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSVMEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMGHGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLRLWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSMEMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAFLLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCYWLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMTYSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVPYLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPMNENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVMLGSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKGGSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS
Atome Classification :
(20 SA)
----------.........10....--.--.--..20........30........40........50......---..60........70........80........90........100.......110.......120.......130.......140.......-150........160.......170.-.......180.......190......----.200---.------......210.......--------220.......230..-..-.-.-.-240-----.-------..-----....-------.---.---250.......260.....--------------------.--------.--270--------.------------------.------------------...-..280.......290.......300--.--......310.......320.......330.......340.......350....-.-.-.360...--....370.....-.--.380...-....390--..-------.....400-..--..---.--.-..-.410.....---..420.......430.......440.......450.......460.......470.......480...------....490.......-----500-------...--.....-510--...-.--..---.520.........530..--.....540...---...---.550.......560.....----------..570----........580----........590...--..-..--600.......---610........620.......630-.-.---.....640-.......650.......660.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MRKLYHGACYYPELW--
D
--
E
--
E
T
I
Q
Q
D
I
D
I
M
R
E
VGV
N
V
V
R
I
G
E
F
A
W
SVMEPEEGK
I
D
V
G
F
F
---
K
E
I
I
A
R
L
Y
DSGI
E
T
I
M
CTPTPTP
P
I
WFSHGRPERMHA
N
E
K
R
E
I
MGHGSRQHACTNNPYF
R
K
K
A
A
I
I
T
T
A
I
A
K
E
L
GRLPGL
I
G
W
QLDN
E
F
K
C
H
-
V
-
A
E
C
M
C
E
T
C
L
R
L
W
H
D
W
L
K
N
R
Y
G
-
V
-
I
E
R
L
N
E
A
WGT
D
V
W
S
E
T
Y
Q
T
F
E
QVPQP----GPA
P
---
F
------
L
H
H
A
S
L
R
T
M
Y
Q
L
F
S
M
E
--------
M
I
A
S
F
A
D
E
Q
A
K
I
I
R
C-YS-D-A-P-I-------T-------HN-----
G
S
V
M
-------
F
---
S
---VD
N
E
R
M
F
Q
NLDFASYDTY--------------------A--------S--QEN--------A------------------
S
------------------
A
F
L
-
L
N
C
D
L
W
R
NLKQGR
P
F
W
I
L
ETSPS
Y
A
--
A
--SLESSAYPHADG
Y
L
Q
A
E
A
V
S
S
YALGSQ
G
F
C
Y
W
L
W
RQQRSGSEISHG
S
V
L
SAWG-E-P-TI
G
Y
Q
N
V
--
L
A
V
E
R
A
R
KEIE
P
-
I
--
I
LSTEPV-Q
A
E
AAM
T
--
Y
S
-------
D
R
A
K
A
F
---
I
K--TE---P--H-RG-
L
R
H
R
S
L
V
T
H
---
F
Y
E
R
I
L
NTGIHRDLIPEGAPLD
G
Y
R
L
L
F
T
P
F
V
P
Y
L
S
S
E
F
I
K
K
A
S
A
FAEAG
G
I
W
I
TGPLTGGR
T
C
E
H
T
I------HTDCGLG
E
L
E
KTSG-----
I
K
--------
T
L
F
--
T
FPMN-ENV--NTG-K--
A
F
---GI--TA
P
L
G
L
W
S
A
V
FDTE--SG
N
T
L
G
T
V
EAG---PGA---G
H
A
F
L
T
ERNYGE
G
K
I
V
M
L
G----------SLPS-----GKE
G
D
A
M
L
E
A
-----
L
V
R
H
Y
A
E
E
A
V
ISSR--SD-VT--PG
T
I
V
APRIG---E-N
G
L
V
W
I
V
V
NMDGKGG
S
V
TLPES-
G
-
T
---
D
L
L
T
H
R
L
E
-KAGRLAVGPH
E
Y
R
V
I
Q
FDNHS
31
HHSearch
82.23
30%
-93
- C1 -
1KWG
6
BGAL_THETH
A:
[1-644]
--------------
M
L
G
V
C
Y
Y
P
E
H
W
--
P
--
K
--
E
R
W
K
E
D
A
R
R
M
R
E
A
G
L
S
H
V
R
I
G
E
F
A
W
A
L
L
E
P
E
P
G
R
L
E
W
G
W
L
---
D
E
A
I
A
T
L
A
A
E
G
L
K
V
V
L
G
T
P
T
A
T
P
P
K
W
L
V
D
R
Y
P
E
I
L
P
V
D
R
E
G
R
R
R
R
F
G
G
R
R
H
Y
C
F
S
S
P
V
Y
R
E
E
A
R
R
I
V
T
L
L
A
E
R
Y
G
G
L
E
A
V
A
G
F
Q
T
D
N
E
Y
G
C
H
-
D
T
V
R
C
Y
C
P
R
C
Q
E
A
F
R
G
W
L
E
A
R
Y
G
-
T
-
I
E
A
L
N
E
A
W
G
T
A
F
W
S
Q
R
Y
R
S
F
A
E
V
E
L
P
----
H
L
T
V
---
A
------
E
P
N
P
S
H
L
L
D
Y
Y
R
F
A
S
D
--------
Q
V
R
A
F
N
R
L
Q
V
E
I
L
R
A
H
A
P
-
G
-
K
-
F
-
V
-------
T
-------
H
N
-----
F
M
G
F
-------
F
T--
D
---
L
D
A
F
A
L
A
Q
D
L
D
F
A
S
W
D
S
Y
--------------------
P
--------
L
--
G
F
T
--------
D
L
MPLP
P
E
E
K
L
R
Y
A
RTGHP
D
------------------
V
A
A
-
F
H
H
D
L
Y
R
G
V
G
-
R
G
R
F
W
V
M
E
Q
Q
P
G
P
V
--
N
--
W
A
P
H
-
N
P
S
P
A
P
G
M
V
R
L
W
T
W
E
A
L
A
H
G
A
E
V
V
S
Y
F
R
W
R
Q
A
P
F
A
Q
E
Q
M
H
A
G
L
H
R
P
D
S
-
A
-
P
-
D
Q
G
F
F
E
A
--
K
R
V
A
E
E
L
A
A
L
A
L
------
P
P
V
A
--
Q
A
P
V
A
L
V
--
F
D
-------
Y
E
A
A
W
I
---
Y
E
--
V
Q
---
P
--
Q
G
A
E
-
W
S
Y
L
G
L
V
Y
L
---
F
Y
S
A
L
R
R
L
G
L
D
V
D
V
V
P
P
G
A
S
L
R
G
Y
A
F
A
V
V
P
S
L
P
I
V
R
E
E
---
A
L
E
A
F
R
E
A
E
G
P
V
L
F
G
P
R
S
G
S
K
T
E
T
F
Q
I
------
P
K
E
L
P
P
G
P
L
Q
A
L
L
P
-----
L
K
--------
V
V
R
--
V
E
S
L
P
-
P
G
L
L
-
E
V
A
-
E
--
G
A
---
L
G
--
R
F
P
L
G
L
W
R
E
W
V
E
A
P
---
L
K
P
L
L
T
-------
F
Q
D
---
G
K
G
A
L
Y
----
R
E
G
R
Y
L
Y
L
A
----------
A
W
P
S
-----
P
----
E
L
A
G
R
-----
L
L
S
A
L
A
A
E
A
G
L
K
V
L
---
S
-
L
P
--
E
G
L
R
L
R
R
R
--------
G
T
W
V
F
A
F
N
Y
G
P
E
A
V
E
A
P
A
S
E
G
-
A
-
R
---
F
L
L
G
S
--------
R
R
V
G
P
Y
D
L
A
V
W
E
E
----
21
Fugue
79.81
29%
-91
- C1 -
1KWG
6
BGAL_THETH
A:
[1-644]
--------------
M
L
G
V
C
Y
Y
P
E
H
W
--
P
--
K
--
E
R
W
K
E
D
A
R
R
M
R
E
A
G
L
S
H
V
R
I
G
E
F
A
W
A
L
L
E
P
E
P
G
R
L
E
W
G
W
L
---
D
E
A
I
A
T
L
A
A
E
G
L
K
V
V
L
G
T
P
T
A
T
P
P
K
W
L
V
D
R
Y
P
E
I
L
P
V
D
R
E
G
R
R
R
R
F
G
G
R
R
H
Y
C
F
S
S
P
V
Y
R
E
E
A
R
R
I
V
T
L
L
A
E
R
Y
G
G
L
E
A
V
A
G
F
Q
T
D
N
E
Y
G
C
H
D
T
-
V
R
C
Y
C
P
R
C
Q
E
A
F
R
G
W
L
E
A
R
Y
G
-
T
-
I
E
A
L
N
E
A
W
G
T
A
F
W
S
Q
R
Y
R
S
F
A
E
V
E
L
P
----
H
L
T
V
---
A
------
E
P
N
P
S
H
L
L
D
Y
Y
R
F
A
S
D
--------
Q
V
R
A
F
N
R
L
Q
V
E
I
L
R
A
-
H
A
P
G
-
K
-
F
-
V
-------
T
-------
H
N
F
----
M
G
F
F
-------
T
---
D
---
L
D
A
F
A
L
A
Q
D
L
D
F
A
S
W
D
S
Y
--------------------
P
--------
L
--
G
F
T
--------
D
------------------
L
MPLP
P
E
E
K
L
R
Y
A
RTGHPD
V
A
A
-
F
H
H
D
L
Y
R
G
V
G
R
G
-
R
F
W
V
M
E
Q
Q
P
G
-
P
--
V
--
N
W
A
P
H
N
P
S
P
A
P
G
M
V
R
L
W
T
W
E
A
L
A
H
G
A
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V
V
S
Y
F
R
W
R
Q
A
P
F
A
Q
E
Q
M
H
A
G
L
H
R
P
D
S
-
A
-
P
-
D
Q
G
F
F
E
A
--
K
R
V
A
E
E
L
A
A
L
A
-------
L
P
P
V
A
-
Q
A
P
V
A
L
V
--
F
D
-------
Y
E
A
A
W
I
---
Y
E
--
V
Q
---
P
--
Q
G
A
E
-
W
S
Y
L
G
L
V
Y
L
---
F
Y
S
A
L
R
R
L
G
L
D
V
D
V
V
P
P
G
A
S
L
R
G
Y
A
F
A
V
V
P
S
L
P
I
V
R
E
E
A
L
E
A
---
F
R
E
A
E
G
P
V
L
F
G
P
R
S
G
S
K
T
E
T
F
Q
I
------
P
K
E
L
P
P
G
P
L
Q
A
L
L
P
-----
L
K
--------
V
V
R
--
V
E
S
L
P
-
P
G
L
L
-
E
V
A
-
E
--
G
A
---
L
G
--
R
F
P
L
G
L
W
R
E
W
V
E
A
P
--
L
K
P
L
L
T
F
Q
D
-----------
G
K
G
A
L
Y
R
E
----
G
R
Y
L
Y
L
A
----------
A
W
P
S
---------
P
E
L
A
G
R
-----
L
L
S
A
L
A
A
E
A
G
L
K
V
L
--
S
---
L
--
P
E
G
L
R
L
R
R
R
G
---
T
----
W
V
F
A
F
N
Y
G
P
E
A
V
E
A
P
A
S
E
G
-
A
-
R
---
F
L
L
--------
G
S
R
R
V
G
P
Y
D
L
A
V
W
E
E
----
35
HHSearch
79.65
25%
-85
- C1 -
4OIF
13
?
A:
[14-685]
------------
F
I
L
H
G
G
D
Y
N
P
D
Q
W
--
L
DR
P
--
D
I
L
Q
A
D
L
E
L
M
K
L
S
H
T
N
T
F
T
V
G
V
F
A
W
S
A
L
E
P
E
E
G
V
Y
R
F
E
W
L
---
D
K
V
F
D
D
I
Y
R
I
G
G
R
V
I
L
A
T
P
S
G
A
R
P
A
W
L
S
Q
K
Y
P
E
V
L
R
V
N
A
A
R
V
R
Q
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H
G
G
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H
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H
C
F
T
S
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V
Y
R
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K
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Q
H
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N
R
L
L
A
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R
Y
G
D
H
P
A
L
L
M
W
H
V
S
N
E
Y
G
G
-----
E
C
H
C
N
L
C
Q
E
A
F
R
E
W
L
K
K
K
Y
N
H
D
-
L
D
A
L
N
A
A
W
W
T
S
F
W
S
H
T
Y
T
D
W
S
Q
I
E
S
P
----
S
P
I
G
---
E
------
H
T
I
H
G
L
N
L
D
W
K
R
F
V
T
D
--------
Q
T
I
S
F
F
E
N
E
I
V
P
L
R
E
L
T
P
-
H
-
I
-
P
-
I
-------
T
-------
T
N
-----
F
M
A
D
T
HDLIPF
Q
---
G
---
L
D
Y
S
K
F
A
K
H
L
D
V
I
S
W
D
A
Y
--------------------
P
--------
A
--
W
H
N
--------
D
WES
T
A
D
L
A
----------
M
------------------
K
V
G
-
F
I
N
D
L
Y
R
S
L
K
-
Q
Q
P
F
L
L
M
E
C
T
P
S
L
V
--
N
--
W
H
K
V
-
N
K
A
K
R
P
G
M
H
F
L
S
S
M
Q
M
I
A
H
G
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D
S
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F
Q
W
R
K
S
R
G
S
F
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K
F
H
G
A
V
V
D
H
D
N
-
R
-
T
D
S
R
V
F
Q
E
V
--
A
E
V
G
K
A
L
K
K
M
S
G
-
I
--
V
G
-
T
N
R
P
--
A
E
V
A
I
L
--
Y
D
-------
W
E
N
N
W
A
---
L
N
--
D
A
QG-
F
--
A
A
E
T
-
K
R
Y
P
Q
T
L
V
Q
---
H
Y
R
P
F
W
E
R
D
I
P
V
D
V
I
T
K
E
H
D
F
S
R
Y
K
L
L
I
A
P
M
L
Y
L
V
S
E
E
T
I
A
R
L
K
E
F
V
A
N
G
G
T
L
V
M
T
Y
I
S
G
I
V
D
E
H
D
L
A
------
Y
L
G
G
W
H
Q
D
L
R
E
M
F
G
-----
M
E
--------
P
I
E
--
T
D
T
L
Y
-
P
R
D
R
N
S
V
H
-
Y
---
R
---
G
R
--
S
Y
E
L
K
D
Y
A
T
V
I
K
I
H
--
A
A
T
V
E
G
V
Y
E
D
D
---
F
Y
A
---
D
T
P
A
V
T
S
N
Q
Y
G
K
G
Q
A
Y
Y
I
G
----------
G
R
L
E
-----
D
----
Q
F
H
R
D
-----
F
Y
Q
E
L
M
E
K
L
D
L
R
P
V
L
F
V
K
-
H
E
--
K
G
V
S
V
Q
A
R
Q
A
---
P
-
E
C
D
Y
V
F
I
M
N
F
T
E
E
K
Q
A
V
V
L
E
E
K
-
V
-
K
---
D
L
F
T
G
E
E
I
--
V
G
E
I
M
L
D
K
Y
E
V
R
V
V
E
K
R
---
22
Fugue
79.52
25%
-80
- C1 -
4OIF
13
?
A:
[2-686]
PKY
E
R
T
Y
TTQ
A
N
F
I
L
H
G
G
D
Y
N
P
D
Q
W
LD
R
--
P
--
D
I
L
Q
A
D
L
E
L
M
K
L
S
H
T
N
T
F
T
V
G
V
F
A
W
S
A
L
E
P
E
E
G
V
Y
R
F
E
W
L
---
D
K
V
F
D
D
I
Y
R
I
G
G
R
V
I
L
A
T
P
S
G
A
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P
A
W
L
S
Q
K
Y
P
E
V
L
R
V
N
A
A
R
V
R
Q
L
H
G
G
R
H
N
H
C
F
T
S
S
V
Y
R
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K
T
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I
N
R
L
L
A
E
R
Y
G
D
H
P
A
L
L
M
W
H
V
S
N
E
Y
G
-----
G
E
C
H
C
N
L
C
Q
E
A
F
R
E
W
L
K
K
K
Y
N
-
H
D
L
D
A
L
N
A
A
W
W
T
S
F
W
S
H
T
Y
T
D
W
S
Q
I
E
S
P
----
S
P
I
G
---
E
------
H
T
I
H
G
L
N
L
D
W
K
R
F
V
T
D
--------
Q
T
I
S
F
F
E
N
E
I
V
P
L
R
E
-
L
T
-
P
H
I
-
P
-
I
-------
T
T
N
F
M
A
D
T
H
D
-----
L
I
P
F
-------
Q
---
G
---
L
D
Y
S
K
F
A
K
H
L
D
V
I
S
W
D
A
Y
--------------------
P
AWHNDWES
T
--
A
D
L
--------
A
------------------
M
------------------
K
V
G
-
F
I
N
D
L
Y
R
S
L
K
Q
-
Q
P
F
L
L
M
E
C
T
P
S
L
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--
N
--
W
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N
-
K
A
K
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M
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F
L
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M
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F
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A
V
V
D
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D
N
-
R
-
T
D
S
R
V
F
Q
E
V
--
A
E
V
G
K
A
L
K
K
M
S
G
-
I
--
V
G
T
N
R
P
---
A
E
V
A
I
L
--
Y
D
-------
W
E
N
N
W
A
---
L
N
--
D
A
QGF
A
--
A
-
E
T
-
K
R
Y
P
Q
T
L
V
Q
---
H
Y
R
P
F
W
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R
D
I
P
V
D
V
I
T
K
E
H
D
F
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R
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L
L
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M
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A
N
G
G
T
L
V
M
T
Y
I
S
G
I
V
D
E
H
D
L
A
------
Y
L
G
G
W
H
Q
D
L
R
E
M
F
G
-----
M
E
--------
P
I
E
--
T
D
T
L
Y
P
R
D
R
--
N
S
V
-
H
--
Y
R
---
G
R
--
S
Y
E
L
K
D
Y
A
T
V
I
K
I
H
--
A
A
T
V
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G
V
Y
E
D
D
---
F
Y
A
---
D
T
P
A
V
T
S
N
Q
Y
G
K
G
Q
A
Y
Y
I
G
-------------------
G
R
L
E
D
Q
F
H
R
D
-----
F
Y
Q
E
L
M
E
K
L
D
L
R
P
V
--
L
F
-
V
K
H
E
K
G
V
S
V
Q
A
R
Q
A
---
P
-
E
C
D
Y
V
F
I
M
N
F
T
E
E
K
Q
A
V
V
L
E
E
K
-
V
-
K
---
D
L
F
T
G
E
-
E
-
I
V
G
E
I
M
L
D
K
Y
E
V
R
V
V
E
K
R
R
--
33
HHSearch
77.58
22%
-83
- C1 -
4UZS
9
?
A:
[18-689]
-----------
S
R
L
W
Y
G
G
D
Y
N
P
D
Q
W
--
P
--
E
--
E
V
W
D
D
D
I
R
L
M
K
K
A
G
V
N
L
V
S
V
G
I
F
S
W
A
K
I
E
P
E
E
G
K
Y
D
F
D
W
L
---
D
R
A
I
D
K
L
G
K
A
G
I
A
V
D
L
A
S
A
T
A
S
P
P
M
W
L
T
Q
A
H
P
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V
L
W
K
D
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R
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D
T
V
W
P
G
A
R
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H
W
R
P
T
S
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V
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Y
A
L
N
L
C
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A
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Y
V
V
A
W
H
V
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N
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Y
G
C
H
-
N
-
R
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D
D
A
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-
T
-
I
D
A
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E
A
W
G
T
A
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A
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H
M
N
D
F
S
E
I
I
P
P
----
R
Y
I
G
DG-
N
------
F
M
N
P
G
K
L
L
D
Y
K
R
F
S
S
D
--------
A
L
K
E
L
Y
I
A
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R
D
V
L
E
S
I
T
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-
G
-
L
-
P
-
L
-------
T
-------
T
N
-----
F
M
V
S
-------
A
GGS
M
---
L
D
Y
D
D
W
G
A
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V
D
F
V
S
N
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Y
--------------------
F
--------
T
--
P
G
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AH------
F
------------------
D
------------------
E
V
A
-
Y
A
A
S
L
M
D
G
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S
R
K
E
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W
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M
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--
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--
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-
N
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V
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L
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-
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-
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F
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--
C
E
L
G
A
D
L
G
R
L
S
D
E
G
--
L
M
G
T
K
T
V
-
K
S
K
V
A
V
V
--
F
D
-------
Y
E
S
Q
W
A
---
T
E
--
Y
T
---
A
NP
T
-
Q
Q
-
V
D
H
W
T
E
P
L
D
---
W
F
R
A
L
A
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N
G
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T
A
D
V
V
P
V
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D
W
D
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V
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Y
L
L
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S
R
R
V
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V
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N
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G
K
L
F
V
T
Y
Y
T
G
L
S
D
E
N
D
H
I
------
W
L
G
G
Y
P
G
S
I
R
D
V
V
G
-----
V
R
--------
V
E
E
--
F
A
P
M
G
-
N
D
M
P-
G
A
L
-
D
--
H
L
D
L
-
D
N
--
G
T
V
A
H
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F
A
D
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I
T
S
T
AD
T
S
T
V
L
A
S
Y
K
A
E
RWT
G
M
N
---
E
V
P
A
I
V
A
N
G
Y
G
D
G
R
T
V
Y
V
G
----------
C
R
L
G
-----
R
----
Q
G
L
A
K
-----
S
L
P
A
M
L
G
S
M
G
L
S
D
----
L
-
A
G
--
D
G
R
V
L
R
V
E
R
A
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AA
A
-
A
S
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F
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F
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R
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V
T
V
D
V
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G
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-
A
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A
---
A
S
L
A
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---
D
D
G
R
A
T
I
D
P
T
G
V
V
V
L
R
R
----
34
HHSearch
77.54
22%
-89
* C1 *
3TTY
2
?
A:
[6-674]
----------
F
P
K
I
W
Y
G
G
D
Y
N
P
E
Q
W
--
D
--
K
--
A
T
M
E
E
D
M
R
M
F
N
L
A
G
I
D
V
A
T
V
N
V
F
S
W
A
K
I
Q
R
D
E
V
S
Y
D
F
T
W
L
---
D
D
I
I
E
R
L
T
K
E
N
I
Y
L
C
L
A
T
S
T
G
A
H
P
A
W
M
A
K
K
Y
P
D
V
L
R
V
D
Y
E
G
R
K
R
K
F
G
G
R
H
N
S
C
P
N
S
P
T
Y
R
K
Y
A
K
I
L
A
G
K
L
A
E
R
Y
K
D
H
P
Q
I
V
M
W
H
V
S
N
E
Y
G
G
-----
Y
C
Y
C
D
N
C
E
K
Q
F
R
V
W
L
K
E
R
Y
G
-
T
-
L
E
A
L
N
K
A
W
N
T
S
F
W
S
H
T
F
Y
D
W
D
E
I
V
A
P
----
N
A
L
S
---
E
EWSGNR
T
N
F
Q
G
I
S
L
D
Y
R
R
F
Q
S
D
--------
S
L
L
E
C
F
K
M
E
R
D
E
L
K
R
W
T
P
-
D
-
I
-
P
-
V
-------
T
-------
T
N
-----
L
M
G
F
Y------
P
---
E
---
L
D
Y
F
K
W
A
K
E
M
D
V
V
S
W
D
N
Y
--------------------
P
--------
S
--
M
D
T
--------
P
F
-----------------
S
------------------
F
T
A
-
M
A
H
N
L
M
R
G
L
K
S
G
Q
P
F
M
L
M
E
Q
T
P
G
V
Q
--
N
--
W
Q
P
Y
-
N
S
A
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R
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M
R
L
W
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A
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A
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V
G
-
H
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T
R
V
F
R
E
C
--
A
E
L
G
K
E
L
Q
Q
L
G
D
-
T
--
I
L
D
A
R
S
E
--
A
K
V
A
V
M
--
Y
D
-------
W
E
N
R
W
A
---
L
E
--
L
S
S--
G
P-
S
-
I
A
-
L
N
Y
V
N
E
V
H
K
---
Y
Y
D
A
L
Y
K
Q
N
I
Q
T
D
M
I
S
V
E
E
D
L
S
K
Y
K
V
V
I
A
P
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M
Y
M
V
K
P
G
F
A
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V
E
R
F
V
A
Q
G
G
T
F
V
T
T
F
F
S
G
I
V
N
E
N
D
L
V
------
T
L
G
G
Y
P
G
E
L
R
N
V
M
G
-----
I
W
--------
A
E
E
--
I
D
A
L
L
-
P
G
H
Q
N
E
I
V
-
L
RQ
D
W
GGL
R
G
--
S
Y
S
C
G
I
L
C
D
V
I
H
A
E
--
T
A
E
V
L
A
E
Y
G
A
D
---
Y
Y
K
---
G
T
P
V
L
T
R
N
K
F
G
N
G
Q
S
Y
Y
V
A
----------
S
S
P
D
-----
A
----
D
F
L
Q
G
-----
L
I
A
N
L
C
E
E
Q
G
V
K
P
L
--
L
N
-
T
P
--
D
G
V
E
V
A
E
R
V
K
---
N
-
G
T
S
Y
L
F
V
M
N
H
N
A
E
E
M
T
F
D
A
G
A
S
R
Q
-
R
---
D
L
L
T
G
K
T
I
--
S
G
Q
A
T
I
P
A
R
G
V
M
I
L
E
R
----
10
PsiBlast_PDB
76.33
25%
-81
- C1 -
4OIF
13
?
A:
[15-683]
-------------
I
L
H
G
G
D
Y
N
P
D
Q
W
--
L
--
D
R
P
D
I
L
Q
A
D
L
E
L
M
K
L
S
H
T
N
T
F
T
V
G
V
F
A
W
S
A
L
E
P
E
E
G
V
Y
R
F
E
W
L
---
D
K
V
F
D
D
I
Y
R
I
G
G
R
V
I
L
A
T
P
S
G
A
R
P
A
W
L
S
Q
K
Y
P
E
V
L
R
V
N
A
A
R
V
R
Q
L
H
G
G
R
H
N
H
C
F
T
S
S
V
Y
R
E
K
T
Q
H
I
N
R
L
L
A
E
R
Y
G
D
H
P
A
L
L
M
W
H
V
S
N
E
Y
G
-----
G
E
C
H
C
N
L
C
Q
E
A
F
R
E
W
L
K
K
K
Y
N
H
D
-
L
D
A
L
N
A
A
W
W
T
S
F
W
S
H
T
Y
T
D
W
S
Q
I
E
S
P
----
S
P
I
G
---
E
------
H
T
I
H
G
L
N
L
D
W
K
R
F
V
T
D
--------
Q
T
I
S
F
F
E
N
E
I
V
P
L
R
E
-
L
T
P
H
-
I
-
P
-
I
T
T
N
F
M
A
D
T
-------
H
D
-----
L
I
P
F
-------
Q
---
G
---
L
D
Y
S
K
F
A
K
H
L
D
V
I
S
W
D
A
Y
--------------------
P
--------
A
--
W
H
N
DWES
T
A
D
L
A
------------------
M
------------------
K
V
G
-
F
I
N
D
L
Y
R
S
L
K
Q
-
Q
P
F
L
L
M
E
C
T
P
S
L
V
--
N
WH
K
V
N
K
A
K
R
P
---
G
M
H
F
L
S
S
M
Q
M
I
A
H
G
S
D
S
I
L
Y
F
Q
W
R
K
S
R
G
S
F
E
K
F
H
G
A
V
V
D
H
D
N
-
R
T
D
-
S
R
V
F
Q
E
V
--
A
E
V
G
K
A
L
K
K
M
S
G
-
I
--
V
G
T
N
R
P
---
A
E
V
A
I
L
--
Y
D
W
E
N
N
W
A
L
N
D
A
Q
G
F
AAE
T
K
--
R
Y
---
P
----------
Q
T
L
V
Q
H
Y
R
P
F
W
E
R
----
D
I
P
V
D
V
I
T
K
E
H
D
F
S
R
Y
K
L
L
I
A
P
M
L
Y
L
V
S
E
E
T
I
A
R
L
K
E
F
V
A
N
G
G
T
L
V
M
T
Y
I
S
-
G
I
V
D
E
H
D
L
AYLGGW
H
Q
D
--
L
R
E
M
F
G
M
E
P
-----
I
E
--------
T
D
T
--
L
Y
P
R
D
-
R
N
S
--
V
H
Y
-
R
-------
G
R
--
S
Y
E
L
K
D
Y
A
T
V
I
K
I
H
--
A
A
T
V
E
G
V
Y
E
D
D
---
F
Y
A
---
D
T
P
A
V
T
S
N
Q
Y
G
K
G
Q
A
Y
Y
I
G
----------
G
R
L
E
-----
D
Q
F
H
R
D
F
Y
Q
E
-----
L
M
E
K
L
D
L
R
P
V
L
F
V
K
--
H
E
-----
K
G
V
S
V
Q
A
R
Q
A
---
P
-
E
C
D
Y
V
F
I
M
N
F
T
E
E
K
Q
A
V
V
L
E
E
K
-
V
-
K
---
D
L
F
T
G
E
-
E
-
I
V
G
E
I
M
L
D
K
Y
E
V
R
V
V
E
-----
12
PsiBlast_PDB
76.22
25%
-84
- C1 -
5DFA
4
?
A:
[15-683]
-------------
I
L
H
G
G
D
Y
N
P
D
Q
W
--
L
--
D
R
P
D
I
L
Q
A
D
L
E
L
M
K
L
S
H
T
N
T
F
T
V
G
V
F
A
W
S
A
L
E
P
E
E
G
V
Y
R
F
E
W
L
---
D
K
V
F
D
D
I
Y
R
I
G
G
R
V
I
L
A
T
P
S
G
A
R
P
A
W
L
S
Q
K
Y
P
E
V
L
R
V
N
A
A
R
V
R
Q
L
H
G
G
R
H
N
H
C
F
T
S
S
V
Y
R
E
K
T
Q
H
I
N
R
L
L
A
E
R
Y
G
D
H
P
A
L
L
M
W
H
V
S
N
E
Y
G
-----
G
E
C
H
C
N
L
C
Q
E
A
F
R
E
W
L
K
K
K
Y
N
H
D
-
L
D
A
L
N
A
A
W
W
T
S
F
W
S
H
T
Y
T
D
W
S
Q
I
E
S
P
----
S
P
I
G
---
E
------
H
T
I
H
G
L
N
L
D
W
K
R
F
V
T
D
--------
Q
T
I
S
F
F
E
N
E
I
V
P
L
R
E
-
L
T
P
H
-
I
-
P
-
I
T
T
N
F
M
A
D
T
-------
H
D
-----
L
I
P
F
-------
Q
---
G
---
L
D
Y
S
K
F
A
K
H
L
D
V
I
S
W
D
A
Y
--------------------
P
--------
A
--
W
H
N
DWES
T
A
D
L
A
------------------
M
------------------
K
V
G
-
F
I
N
D
L
Y
R
S
L
K
Q
-
Q
P
F
L
L
M
A
C
T
P
S
L
V
--
N
WH
K
V
N
K
A
K
R
P
---
G
M
H
F
L
S
S
M
Q
M
I
A
H
G
S
D
S
I
L
Y
F
Q
W
R
K
S
R
G
S
F
E
K
F
H
G
A
V
V
D
H
D
N
-
R
T
D
-
S
R
V
F
Q
E
V
--
A
E
V
G
K
A
L
K
K
M
S
G
-
I
--
V
G
T
N
R
P
---
A
E
V
A
I
L
--
Y
D
W
E
N
N
W
A
L
N
D
A
Q
G
F
AAE
T
K
--
R
Y
---
P
----------
Q
T
L
V
Q
H
Y
R
P
F
W
E
R
----
D
I
P
V
D
V
I
T
K
E
H
D
F
S
R
Y
K
L
L
I
A
P
M
L
Y
L
V
S
E
E
T
I
A
R
L
K
E
F
V
A
N
G
G
T
L
V
M
T
Y
I
S
-
G
I
V
D
E
H
D
L
A
Y
L
GGW
H
Q
D
--
L
R
E
M
F
G
M
E
P
-----
I
E
--------
T
D
T
--
L
Y
P
R
D
-
R
N
S
--
V
H
Y
-
R
-------
G
R
--
S
Y
E
L
K
D
Y
A
T
V
I
K
I
H
--
A
A
T
V
E
G
V
Y
E
D
D
---
F
Y
A
---
D
T
P
A
V
T
S
N
Q
Y
G
K
G
Q
A
Y
Y
I
G
----------
G
R
L
E
-----
D
Q
F
H
R
D
F
Y
Q
E
-----
L
M
E
K
L
D
L
R
P
V
L
F
V
K
--
H
E
-----
K
G
V
S
V
Q
A
R
Q
A
---
P
-
E
C
D
Y
V
F
I
M
N
F
T
E
E
K
Q
A
V
V
L
E
E
K
-
V
-
K
---
D
L
F
T
G
E
-
E
-
I
V
G
E
I
M
L
D
K
Y
E
V
R
V
V
E
-----
11
PsiBlast_PDB
76.07
25%
-82
- C1 -
4OJY
4
?
A:
[16-684]
-------------
I
L
H
G
G
D
Y
N
P
D
Q
W
--
L
--
D
R
P
D
I
L
Q
A
D
L
E
L
M
K
L
S
H
T
N
T
F
T
V
G
V
F
A
W
S
A
L
E
P
E
E
G
V
Y
R
F
E
W
L
---
D
K
V
F
D
D
I
Y
R
I
G
G
R
V
I
L
A
T
P
S
G
A
R
P
A
W
L
S
Q
K
Y
P
E
V
L
R
V
N
A
A
R
V
R
Q
L
H
G
G
R
H
N
H
C
F
T
S
S
V
Y
R
E
K
T
Q
H
I
N
R
L
L
A
E
R
Y
G
D
H
P
A
L
L
M
W
H
V
S
N
E
Y
G
-----
G
E
C
H
C
N
L
C
Q
E
A
F
R
E
W
L
K
K
K
Y
N
H
D
-
L
D
A
L
N
A
A
W
W
T
S
F
W
S
H
T
Y
T
D
W
S
Q
I
E
S
P
----
S
P
I
G
---
E
------
H
T
I
H
G
L
N
L
D
W
K
R
F
V
T
D
--------
Q
T
I
S
F
F
E
N
E
I
V
P
L
R
E
-
L
T
P
H
-
I
-
P
-
I
T
T
N
F
M
A
D
T
-------
H
D
-----
L
I
P
F
-------
Q
---
G
---
L
D
Y
S
K
F
A
K
H
L
D
V
I
S
W
D
A
Y
--------------------
P
--------
A
--
W
H
N
DWES
T
A
D
L
A
------------------
M
------------------
K
V
G
-
F
I
N
D
L
Y
R
S
L
K
Q
-
Q
P
F
L
L
M
E
C
T
P
S
L
V
--
N
WH
K
V
N
K
A
K
R
P
---
G
M
H
F
L
S
S
M
Q
M
I
A
H
G
S
D
S
I
L
Y
F
Q
W
R
K
S
R
G
S
F
E
K
F
H
G
A
V
V
D
H
D
N
-
R
T
D
-
S
R
V
F
Q
E
V
--
A
E
V
G
K
A
L
K
K
M
S
G
-
I
--
V
G
T
N
R
P
---
A
E
V
A
I
L
--
Y
D
W
E
N
N
W
A
L
N
D
A
Q
G
F
AAE
T
K
--
R
Y
---
P
----------
Q
T
L
V
Q
H
Y
R
P
F
W
E
R
----
D
I
P
V
D
V
I
T
K
E
H
D
F
S
R
Y
K
L
L
I
A
P
M
L
Y
L
V
S
E
E
T
I
A
R
L
K
E
F
V
A
N
G
G
T
L
V
M
T
Y
I
S
G
I
-
V
D
E
H
D
L
A
Y
L
GGW
H
Q
D
--
L
R
E
M
F
G
M
E
P
-----
I
E
--------
T
D
T
--
L
Y
P
R
D
-
R
N
S
--
V
H
Y
-
R
-------
G
R
--
S
Y
E
L
K
D
Y
A
T
V
I
K
I
H
--
A
A
T
V
E
G
V
Y
E
D
D
---
F
Y
A
---
D
T
P
A
V
T
S
N
Q
Y
G
K
G
Q
A
Y
Y
I
G
----------
G
R
L
E
-----
D
Q
F
H
R
D
F
Y
Q
E
-----
L
M
E
K
L
D
L
R
P
V
L
F
V
K
--
H
E
-----
K
G
V
S
V
Q
A
R
Q
A
---
P
-
E
C
D
Y
V
F
I
M
N
F
T
E
E
K
Q
A
V
V
L
E
E
K
-
V
-
K
---
D
L
F
T
G
E
-
E
-
I
V
G
E
I
M
L
D
K
Y
E
V
R
V
V
E
-----
32
HHSearch
75.86
22%
-90
- C1 -
4UOZ
4
?
A:
[21-695]
-----------
R
K
I
W
F
G
A
D
Y
N
P
D
Q
W
--
P
--
E
--
D
V
Q
D
E
D
I
R
L
M
K
Q
A
G
V
N
I
V
S
L
A
I
F
S
W
A
N
I
E
T
S
D
G
N
F
E
F
D
W
L
---
D
R
V
I
D
K
L
Y
K
A
G
I
A
V
D
L
A
S
A
T
A
S
P
P
M
W
L
T
S
A
H
P
E
V
L
R
R
D
E
Q
G
H
V
I
W
P
G
A
R
Q
H
W
R
P
T
S
P
T
F
R
T
Y
A
L
R
L
C
R
E
M
A
E
H
Y
K
D
N
P
A
I
V
S
W
H
V
G
N
E
Y
G
C
H
-
N
-
Y
F
D
Y
S
D
D
A
V
Q
A
F
R
E
W
C
R
D
R
Y
G
-
T
-
I
D
K
V
N
A
A
W
G
T
N
F
W
S
Q
R
L
N
S
F
E
E
I
L
P
P
----
R
Y
V
G
GEG
N
------
F
T
N
P
G
R
L
L
D
F
K
H
F
C
S
D
--------
A
L
K
E
F
F
C
A
E
R
D
V
L
S
E
V
T
P
-
N
-
I
-
P
-
L
-------
T
-------
T
N
-----
F
M
V
S
-------
A
SQN
T
---
L
D
Y
D
D
W
A
H
E
V
D
F
V
S
N
D
H
Y
--------------------
F
--------
T
--
P
G
S
W
H
------
I
------------------
D
------------------
E
L
A
-
Y
S
A
S
L
V
D
G
I
S
R
K
K
P
W
F
L
M
A
Q
S
T
S
A
V
--
N
--
W
R
E
I
-
N
P
R
K
E
P
G
E
L
I
R
D
S
M
L
H
L
A
M
G
A
D
A
I
C
Y
F
Q
W
R
Q
S
R
S
G
A
E
K
F
H
S
A
M
L
P
L
A
G
-
E
-
H
-
S
Q
I
Y
R
D
V
--
C
A
L
G
A
D
L
D
T
L
S
D
-
A
GI
L
R
S
K
L
S
--
K
A
R
V
A
I
V
--
Q
D
-------
I
Q
S
E
W
A
---
T
E
--
H
T
---
A
TP
T
-
Q
H
-
I
R
E
W
T
E
P
L
D
---
W
F
A
A
F
A
N
R
G
V
T
A
D
V
T
P
I
H
A
Q
W
D
T
Y
D
A
V
V
I
P
C
V
Y
L
F
S
E
E
M
A
E
R
L
R
T
F
V
R
N
G
G
K
A
F
V
T
Y
Y
S
A
L
A
D
E
H
D
R
L
------
H
T
E
G
W
P
G
L
I
G
D
V
V
G
-----
V
R
--------
I
E
E
--
H
C
P
L
G
-
T
L
F
--
P
G
M
L
D
--
H
L
D
V
-
S
N
--
G
T
V
V
H
D
L
A
D
V
I
D
A
I
AD
D
T
T
V
L
A
T
F
E
A
D
PAT
G
M
D
---
G
R
A
A
I
T
V
H
P
Y
H
E
G
G
V
A
Y
I
A
----------
G
K
L
G
-----
R
----
D
G
I
S
Q
-----
S
L
P
E
I
C
A
A
L
G
F
E
L
D
--
A
D
P
R
A
--
G
D
V
L
R
V
V
R
E
Q
---
E
D
G
A
I
F
E
F
L
F
N
R
T
R
N
T
V
T
A
D
R
P
A
G
-
D
-----
M
L
I
C
S
L
A
T
D
S
T
D
K
V
T
L
E
P
N
G
V
L
A
F
R
R
----
5
PsiBlast_PDB
74.05
24%
-82
- C1 -
4UOQ
8
?
A:
[21-672]
-----------
R
K
I
W
F
G
A
D
Y
N
P
D
Q
W
--
P
--
E
--
D
V
Q
D
E
D
I
R
L
M
K
Q
A
G
V
N
I
V
S
L
A
I
F
S
W
A
N
I
E
T
S
D
G
N
F
E
F
D
W
L
---
D
R
V
I
D
K
L
Y
K
A
G
I
A
V
D
L
A
S
A
T
A
S
P
P
M
W
L
T
S
A
H
P
E
V
L
R
R
D
E
Q
G
H
V
I
W
P
G
A
R
Q
H
W
R
P
T
S
P
T
F
R
T
Y
A
L
R
L
C
R
E
M
A
E
H
Y
K
D
N
P
A
I
V
S
W
H
V
G
N
E
Y
G
C
H
-
N
-
Y
F
D
Y
S
D
D
A
V
Q
A
F
R
E
W
C
R
D
R
Y
G
-
T
-
I
D
K
V
N
A
A
W
G
T
N
F
W
S
Q
R
L
N
S
F
E
E
I
L
P
P
RY---------
F
------
T
N
P
G
R
L
L
D
F
K
H
F
C
S
D
A
--------
L
K
E
F
F
C
A
E
R
D
V
L
S
E
V
-
T
P
-
N
-
I
-
P
-
L
-------
T
-------
T
N
-----
F
M
V
S
-------
A
---
S
QNT
L
D
Y
D
D
W
A
H
E
V
D
F
V
S
N
D
H
Y
--------------------
F
--------
T
P
G
S
W
H
--------
I
------------------
D
------------------
E
L
A
-
Y
S
A
S
L
V
D
G
I
S
R
K
K
P
W
F
L
M
A
Q
S
T
S
A
V
--
N
--
W
R
E
I
N
P
R
K
E
P
-
G
E
L
I
R
D
S
M
L
H
L
A
M
G
A
D
A
I
C
Y
F
Q
W
R
Q
S
R
S
G
A
E
K
F
H
S
A
M
L
P
L
A
G
-
E
-
H
-
S
Q
I
Y
R
D
V
--
C
A
L
G
A
D
L
D
T
L
S
D
-
A
G-
I
L
R
S
K
L
S
-
K
A
R
V
A
I
V
--
Q
D
-------
I
Q
S
E
W
A
---
T
E
HT
A
T
---
P
--
T
-
Q
H
-
I
R
E
W
T
E
P
L
D
---
W
F
A
A
F
A
N
R
G
V
T
A
D
V
T
P
I
H
A
Q
W
D
T
Y
D
A
V
V
I
P
C
V
Y
L
F
S
E
E
M
A
E
R
L
R
T
F
V
R
N
G
G
K
A
F
V
T
Y
Y
S
A
L
A
D
E
H
D
R
L
------
H
T
E
G
W
P
G
L
I
G
D
V
V
G
-----
V
R
IE
E
H
C
P
L
G
T
L
F
--
P
-
G
M
L
-
D
H
L
--
D
V
S
-
N
--
G
T
---
V
V
--
H
D
L
A
D
V
I
D
A
I
A
D
D
T
--
T
--
V
L
A
T
F
E
A
D
---
P
A
T
GMD
G
R
A
A
I
T
V
H
P
Y
H
E
G
G
V
A
Y
I
A
GKLG
R
D
G
I
S
Q
S
L
P
E
I
C
A
A
L
G
F
E
L
D
A
D
P
R
A
GD
V
L
R
V
V
R
E
Q
E
D
G
A
I
F
E
F
L
--
F
N
-
R
T
--
R
N
T
V
T
A
D
R
P
A
---
G
-
D
M
L
I
-------------------------------------------------------
4
PsiBlast_PDB
73.78
24%
-82
- C1 -
4UOZ
4
?
A:
[21-672]
-----------
R
K
I
W
F
G
A
D
Y
N
P
D
Q
W
--
P
--
E
--
D
V
Q
D
E
D
I
R
L
M
K
Q
A
G
V
N
I
V
S
L
A
I
F
S
W
A
N
I
E
T
S
D
G
N
F
E
F
D
W
L
---
D
R
V
I
D
K
L
Y
K
A
G
I
A
V
D
L
A
S
A
T
A
S
P
P
M
W
L
T
S
A
H
P
E
V
L
R
R
D
E
Q
G
H
V
I
W
P
G
A
R
Q
H
W
R
P
T
S
P
T
F
R
T
Y
A
L
R
L
C
R
E
M
A
E
H
Y
K
D
N
P
A
I
V
S
W
H
V
G
N
E
Y
G
C
H
-
N
-
Y
F
D
Y
S
D
D
A
V
Q
A
F
R
E
W
C
R
D
R
Y
G
-
T
-
I
D
K
V
N
A
A
W
G
T
N
F
W
S
Q
R
L
N
S
F
E
E
I
L
P
P
RYVG
G
E
G
N
---
F
------
T
N
P
G
R
L
L
D
F
K
H
F
C
S
D
A
--------
L
K
E
F
F
C
A
E
R
D
V
L
S
E
V
-
T
P
-
N
-
I
-
P
-
L
-------
T
-------
T
N
-----
F
M
V
S
-------
A
---
S
QNT
L
D
Y
D
D
W
A
H
E
V
D
F
V
S
N
D
H
Y
--------------------
F
--------
T
P
G
S
W
H
--------
I
------------------
D
------------------
E
L
A
-
Y
S
A
S
L
V
D
G
I
S
R
K
K
P
W
F
L
M
A
Q
S
T
S
A
V
--
N
--
W
R
E
I
N
P
R
K
E
P
-
G
E
L
I
R
D
S
M
L
H
L
A
M
G
A
D
A
I
C
Y
F
Q
W
R
Q
S
R
S
G
A
E
K
F
H
S
A
M
L
P
L
A
G
-
E
-
H
-
S
Q
I
Y
R
D
V
--
C
A
L
G
A
D
L
D
T
L
S
D
-
A
G-
I
L
R
S
K
L
S
-
K
A
R
V
A
I
V
--
Q
D
-------
I
Q
S
E
W
A
---
T
E
HT
A
T
---
P
--
T
-
Q
H
-
I
R
E
W
T
E
P
L
D
---
W
F
A
A
F
A
N
R
G
V
T
A
D
V
T
P
I
H
A
Q
W
D
T
Y
D
A
V
V
I
P
C
V
Y
L
F
S
E
E
M
A
E
R
L
R
T
F
V
R
N
G
G
K
A
F
V
T
Y
Y
S
A
L
A
D
E
H
D
R
L
------
H
T
E
G
W
P
G
L
I
G
D
V
V
G
-----
V
R
IE
E
H
C
P
L
G
T
L
F
--
P
-
G
M
L
-
D
H
L
--
D
V
S
-
N
--
G
T
---
V
V
--
H
D
L
A
D
V
I
D
A
I
A
D
D
T
--
T
--
V
L
A
T
F
E
A
D
---
P
A
T
GMD
G
R
A
A
I
T
V
H
P
Y
H
E
G
G
V
A
Y
I
A
GKLG
R
D
G
I
S
Q
S
L
P
E
I
C
A
A
L
G
F
E
L
D
A
D
P
R
A
GD
V
L
R
V
V
R
E
Q
E
D
G
A
I
F
E
F
L
--
F
N
-
R
T
--
R
N
T
V
T
A
D
R
P
A
---
G
-
D
M
L
I
-------------------------------------------------------
6
PsiBlast_PDB
73.48
24%
-81
- C1 -
3TTS
1
?
A:
[8-656]
------------
K
I
W
Y
G
G
D
Y
N
P
E
Q
W
--
D
--
K
--
A
T
M
E
E
D
M
R
M
F
N
L
A
G
I
D
V
A
T
V
N
V
F
S
W
A
K
I
Q
R
D
E
V
S
Y
D
F
T
W
L
---
D
D
I
I
E
R
L
T
K
E
N
I
Y
L
C
L
A
T
S
T
G
A
H
P
A
W
M
A
K
K
Y
P
D
V
L
R
V
D
Y
E
G
R
K
R
K
F
G
G
R
H
N
S
C
P
N
S
P
T
Y
R
K
Y
A
K
I
L
A
G
K
L
A
E
R
Y
K
D
H
P
Q
I
V
M
W
H
V
S
N
E
Y
G
G
Y
-----
C
Y
C
D
N
C
E
K
Q
F
R
V
W
L
K
E
R
Y
G
-
T
-
L
E
A
L
N
K
A
W
N
T
S
F
W
S
H
T
F
Y
D
W
D
E
I
V
A
P
----
N
-
A
L
---
S
------
E
E
W
S
G
N
R
T
N
F
Q
G
I
S
L
D
Y
R
R
F
Q
S
D
S
L
L
E
C
F
K
M
E
R
D
E
L
K
R
W
-
T
P
-
D
-
I
-
P
-
V
-------
T
-------
T
N
-----
L
M
G
F
-------
Y
P--
E
---
L
D
Y
F
K
W
A
K
E
M
D
V
V
S
W
D
N
Y
--------------------
P
--------
S
--
M
D
T
--------
P
------------------
F
------------------
S
F
T
A
M
A
H
N
L
M
R
G
L
K
S
G
Q
P
F
M
L
M
E
Q
T
P
G
V
Q
NW
Q
--
P
Y
N
S
A
K
R
P
---
G
V
M
R
L
W
S
Y
Q
A
V
A
H
G
A
D
T
V
M
F
F
Q
L
R
R
S
V
G
A
C
E
K
Y
H
G
A
V
I
E
H
V
G
H
E
-
H
-
T
R
V
F
R
E
C
--
A
E
L
G
K
E
L
Q
Q
L
G
D
-
T
--
I
L
D
A
R
S
--
E
A
K
V
A
V
M
--
Y
D
W
E
-----
N
R
W
A
L
E
---
L
S
--
S
G
---
P
--
S
-
I
A
-
L
N
Y
V
N
E
V
H
K
---
Y
Y
D
A
L
Y
K
Q
N
I
Q
T
D
M
I
S
V
E
E
D
L
S
K
Y
K
V
V
I
A
P
V
M
Y
M
V
K
P
G
F
A
E
R
V
E
R
F
V
A
Q
G
G
T
F
V
T
T
F
F
S
G
I
V
N
E
N
D
L
V
------
T
L
G
G
Y
P
G
E
L
R
N
V
M
G
IWAE
E
I
D
--------
A
L
L
--
P
G
H
Q
N
-
E
I
V
--
L
R
Q
-
D
--
W
G
---
G
L
R
G
S
Y
S
C
G
I
L
C
D
V
I
H
A
E
--
T
A
E
V
L
A
E
Y
G
A
D
---
Y
Y
K
---
G
T
P
V
L
T
R
N
K
F
G
N
G
Q
S
Y
Y
V
A
----------
S
S
P
D
-----
A
D
----
F
L
Q
G
-----
L
I
A
N
L
C
E
E
Q
G
V
K
P
L
--
L
N
-
T
P
--
D
G
V
E
V
A
E
R
V
----
K
-
N
G
T
S
Y
L
F
V
-
M
N
H
N
A
E
E
M
T
F
D
A
G
-
A
-
S
R
Q
R
D
L
L
T
G
K
------------------------
7
PsiBlast_PDB
72.96
24%
-83
- C1 -
3TTY
2
?
A:
[8-656]
------------
K
I
W
Y
G
G
D
Y
N
P
E
Q
W
--
D
--
K
--
A
T
M
E
E
D
M
R
M
F
N
L
A
G
I
D
V
A
T
V
N
V
F
S
W
A
K
I
Q
R
D
E
V
S
Y
D
F
T
W
L
---
D
D
I
I
E
R
L
T
K
E
N
I
Y
L
C
L
A
T
S
T
G
A
H
P
A
W
M
A
K
K
Y
P
D
V
L
R
V
D
Y
E
G
R
K
R
K
F
G
G
R
H
N
S
C
P
N
S
P
T
Y
R
K
Y
A
K
I
L
A
G
K
L
A
E
R
Y
K
D
H
P
Q
I
V
M
W
H
V
S
N
E
Y
G
G
Y
-----
C
Y
C
D
N
C
E
K
Q
F
R
V
W
L
K
E
R
Y
G
-
T
-
L
E
A
L
N
K
A
W
N
T
S
F
W
S
H
T
F
Y
D
W
D
E
I
V
A
P
----
N
-
A
L
---
S
------
E
E
W
S
G
N
R
T
N
F
Q
G
I
S
L
D
Y
R
R
F
Q
S
D
S
L
L
E
C
F
K
M
E
R
D
E
L
K
R
W
-
T
P
-
D
-
I
-
P
-
V
-------
T
-------
T
N
-----
L
M
G
F
-------
Y
P--
E
---
L
D
Y
F
K
W
A
K
E
M
D
V
V
S
W
D
N
Y
--------------------
P
--------
S
--
M
D
T
--------
P
------------------
F
------------------
S
F
T
A
M
A
H
N
L
M
R
G
L
K
S
G
Q
P
F
M
L
M
E
Q
T
P
G
V
Q
NW
Q
--
P
Y
N
S
A
K
R
P
---
G
V
M
R
L
W
S
Y
Q
A
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A
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A
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M
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R
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V
G
A
C
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Y
H
G
A
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G
H
E
-
H
-
T
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V
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R
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C
--
A
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K
E
L
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Q
L
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D
-
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--
I
L
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A
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--
E
A
K
V
A
V
M
--
Y
D
W
E
-----
N
R
W
A
L
E
---
L
S
--
S
G
---
P
--
S
-
I
A
-
L
N
Y
V
N
E
V
H
K
---
Y
Y
D
A
L
Y
K
Q
N
I
Q
T
D
M
I
S
V
E
E
D
L
S
K
Y
K
V
V
I
A
P
V
M
Y
M
V
K
P
G
F
A
E
R
V
E
R
F
V
A
Q
G
G
T
F
V
T
T
F
F
S
G
I
V
N
E
N
D
L
V
------
T
L
G
G
Y
P
G
E
L
R
N
V
M
G
IWAE
E
I
D
--------
A
L
L
--
P
G
H
Q
N
-
E
I
V
--
L
R
Q
-
D
--
W
G
---
G
L
R
G
S
Y
S
C
G
I
L
C
D
V
I
H
A
E
--
T
A
E
V
L
A
E
Y
G
A
D
---
Y
Y
K
---
G
T
P
V
L
T
R
N
K
F
G
N
G
Q
S
Y
Y
V
A
----------
S
S
P
D
-----
A
D
----
F
L
Q
G
-----
L
I
A
N
L
C
E
E
Q
G
V
K
P
L
--
L
N
-
T
P
--
D
G
V
E
V
A
E
R
V
----
K
-
N
G
T
S
Y
L
F
V
-
M
N
H
N
A
E
E
M
T
F
D
A
G
-
A
-
S
RQR
D
L
L
T
G
K
------------------------
3
PsiBlast_PDB
72.84
24%
-80
- C1 -
4UNI
10
?
A:
[21-672]
-----------
R
K
I
W
F
G
A
D
Y
N
P
D
Q
W
--
P
--
E
--
D
V
Q
D
E
D
I
R
L
M
K
Q
A
G
V
N
I
V
S
L
A
I
F
S
W
A
N
I
E
T
S
D
G
N
F
E
F
D
W
L
---
D
R
V
I
D
K
L
Y
K
A
G
I
A
V
D
L
A
S
A
T
A
S
P
P
M
W
L
T
S
A
H
P
E
V
L
R
R
D
E
Q
G
H
V
I
W
P
G
A
R
Q
H
W
R
P
T
S
P
T
F
R
T
Y
A
L
R
L
C
R
E
M
A
E
H
Y
K
D
N
P
A
I
V
S
W
H
V
G
N
E
Y
G
C
H
-
N
-
Y
F
D
Y
S
D
D
A
V
Q
A
F
R
E
W
C
R
D
R
Y
G
-
T
-
I
D
K
V
N
A
A
W
G
T
N
F
W
S
Q
R
L
N
S
F
E
E
I
L
P
P
RYVG
G
E
G
N
---
F
------
T
N
P
G
R
L
L
D
F
K
H
F
C
S
D
A
--------
L
K
E
F
F
C
A
E
R
D
V
L
S
E
V
-
T
P
-
N
-
I
-
P
-
L
-------
T
-------
T
N
-----
F
M
V
S
-------
A
---
S
QNT
L
D
Y
D
D
W
A
H
E
V
D
F
V
S
N
D
H
Y
--------------------
F
--------
T
P
G
S
W
H
--------
I
------------------
D
------------------
E
L
A
-
Y
S
A
S
L
V
D
G
I
S
R
K
K
P
W
F
L
M
E
Q
S
T
S
A
V
--
N
--
W
R
E
I
N
P
R
K
E
P
-
G
E
L
I
R
D
S
M
L
H
L
A
M
G
A
D
A
I
C
Y
F
Q
W
R
Q
S
R
S
G
A
E
K
F
H
S
A
M
L
P
L
A
G
-
E
-
H
-
S
Q
I
Y
R
D
V
--
C
A
L
G
A
D
L
D
T
L
S
D
-
A
G-
I
L
R
S
K
L
S
-
K
A
R
V
A
I
V
--
Q
D
-------
I
Q
S
E
W
A
---
T
E
HT
A
T
---
P
--
T
-
Q
H
-
I
R
E
W
T
E
P
L
D
---
W
F
A
A
F
A
N
R
G
V
T
A
D
V
T
P
I
H
A
Q
W
D
T
Y
D
A
V
V
I
P
C
V
Y
L
F
S
E
E
M
A
E
R
L
R
T
F
V
R
N
G
G
K
A
F
V
T
Y
Y
S
A
L
A
D
E
H
D
R
L
------
H
T
E
G
W
P
G
L
I
G
D
V
V
G
-----
V
R
IE
E
H
C
P
L
G
T
L
F
--
P
-
G
M
L
-
D
H
L
--
D
V
S
-
N
--
G
T
---
V
V
--
H
D
L
A
D
V
I
D
A
I
A
D
D
T
--
T
--
V
L
A
T
F
E
A
D
---
P
A
T
GMD
G
R
A
A
I
T
V
H
P
Y
H
E
G
G
V
A
Y
I
A
GKLG
R
D
G
I
S
Q
S
L
P
E
I
C
A
A
L
G
F
E
L
D
A
D
P
R
A
GD
V
L
R
V
V
R
E
Q
E
D
G
A
I
F
E
F
L
--
F
N
-
R
T
--
R
N
T
V
T
A
D
R
P
A
---
G
-
D
M
L
I
-------------------------------------------------------
1
PsiBlast_PDB
72.27
31%
-82
- C1 -
1KWG
6
BGAL_THETH
A:
[3-583]
----------------
G
V
C
Y
Y
P
E
H
W
--
P
--
K
--
E
R
W
K
E
D
A
R
R
M
R
E
A
G
L
S
H
V
R
I
G
E
F
A
W
A
L
L
E
P
E
P
G
R
L
E
W
G
W
L
---
D
E
A
I
A
T
L
A
A
E
G
L
K
V
V
L
G
T
P
T
A
T
P
P
K
W
L
V
D
R
Y
P
E
I
L
P
V
D
R
E
G
R
R
R
R
F
G
G
R
R
H
Y
C
F
S
S
P
V
Y
R
E
E
A
R
R
I
V
T
L
L
A
E
R
Y
G
G
L
E
A
V
A
G
F
Q
T
D
N
E
Y
G
C
H
D
T
-
V
R
C
Y
C
P
R
C
Q
E
A
F
R
G
W
L
E
A
R
Y
G
-
T
-
I
E
A
L
N
E
A
W
G
T
A
F
W
S
Q
R
Y
R
S
F
A
E
V
E
L
P
----
H
L
T
V
---
A
------
E
P
N
P
S
H
L
L
D
Y
Y
R
F
A
S
D
--------
Q
V
R
A
F
N
R
L
Q
V
E
I
L
R
A
-
H
A
-
P
-
G
-
K
F
V
-------
T
-------
H
N
-----
F
M
G
F
-------
F
---
T
D--
L
D
A
F
A
L
A
Q
D
L
D
F
A
S
W
D
S
Y
P
L
G
F
T
D
L
MPLP
P
E
E
K
L
R
Y
A
R
T
--------
G
--
H
P
D
--------
V
------------------
A
------------------
A
F
---
H
H
D
L
Y
R
G
V
G
R
G
R
-
F
W
V
M
E
Q
Q
P
G
P
V
--
N
--
W
A
P
H
N
P
S
P
-
A
P
G
M
V
R
L
W
T
W
E
A
L
A
H
G
A
E
V
V
S
Y
F
R
W
R
Q
A
P
F
A
Q
E
Q
M
H
A
G
L
H
R
P
D
S
-
A
-
P
-
D
Q
G
F
-------
F
E
A
K
R
V
A
E
E
L
-
A
--
A
L
A
L
P
P
V
A
Q
A
P
V
A
L
V
--
F
D
-------
Y
E
A
A
W
I
---
Y
E
--
V
Q
---
P
--
Q
-
G
A
E
W
S
Y
L
G
L
V
Y
L
---
F
Y
S
A
L
R
R
L
G
L
D
V
D
V
V
P
P
G
A
S
L
R
G
Y
A
F
A
V
V
P
S
L
P
I
V
R
E
E
A
L
E
---
A
F
R
E
A
E
G
P
V
L
F
G
P
R
S
G
S
K
T
E
T
F
Q
I
------
P
K
E
L
P
P
G
P
L
Q
A
L
L
P
-----
L
K
--------
V
V
R
V
E
S
L
P
P
G
-
L
L
E
--
V
A
E
-
G
--
A
L
---
G
---
R
F
P
L
G
L
W
R
E
W
V
E
A
P
--
L
K
P
L
L
-
T
F
Q
D
G
---
K
G
A
-----------
L
Y
R
E
G
R
Y
L
Y
L
A
----------
A
W
P
S
-----
P
E
L
A
G
R
L
L
S
A
-----
L
------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.00
31%
-82
- C1 -
1KWK
7
BGAL_THETH
A:
[3-583]
----------------
G
V
C
Y
Y
P
E
H
W
--
P
--
K
--
E
R
W
K
E
D
A
R
R
M
R
E
A
G
L
S
H
V
R
I
G
E
F
A
W
A
L
L
E
P
E
P
G
R
L
E
W
G
W
L
---
D
E
A
I
A
T
L
A
A
E
G
L
K
V
V
L
G
T
P
T
A
T
P
P
K
W
L
V
D
R
Y
P
E
I
L
P
V
D
R
E
G
R
R
R
R
F
G
G
R
R
H
Y
C
F
S
S
P
V
Y
R
E
E
A
R
R
I
V
T
L
L
A
E
R
Y
G
G
L
E
A
V
A
G
F
Q
T
D
N
E
Y
G
C
H
D
T
-
V
R
C
Y
C
P
R
C
Q
E
A
F
R
G
W
L
E
A
R
Y
G
-
T
-
I
E
A
L
N
E
A
W
G
T
A
F
W
S
Q
R
Y
R
S
F
A
E
V
E
L
P
----
H
L
T
V
---
A
------
E
P
N
P
S
H
L
L
D
Y
Y
R
F
A
S
D
--------
Q
V
R
A
F
N
R
L
Q
V
E
I
L
R
A
-
H
A
-
P
-
G
-
K
F
V
-------
T
-------
H
N
-----
F
M
G
F
-------
F
---
T
D--
L
D
A
F
A
L
A
Q
D
L
D
F
A
S
W
D
S
Y
P
L
G
F
T
D
L
MPLP
P
E
E
K
L
R
Y
A
R
T
--------
G
--
H
P
D
--------
V
------------------
A
------------------
A
F
---
H
H
D
L
Y
R
G
V
G
R
G
R
-
F
W
V
M
E
Q
Q
P
G
P
V
--
N
--
W
A
P
H
N
P
S
P
-
A
P
G
M
V
R
L
W
T
W
E
A
L
A
H
G
A
E
V
V
S
Y
F
R
W
R
Q
A
P
F
A
Q
E
Q
M
H
A
G
L
H
R
P
D
S
-
A
-
P
-
D
Q
G
F
-------
F
E
A
K
R
V
A
E
E
L
-
A
--
A
L
A
L
P
P
V
A
Q
A
P
V
A
L
V
--
F
D
-------
Y
E
A
A
W
I
---
Y
E
--
V
Q
---
P
--
Q
-
G
A
E
W
S
Y
L
G
L
V
Y
L
---
F
Y
S
A
L
R
R
L
G
L
D
V
D
V
V
P
P
G
A
S
L
R
G
Y
A
F
A
V
V
P
S
L
P
I
V
R
E
E
A
L
E
---
A
F
R
E
A
E
G
P
V
L
F
G
P
R
S
G
S
K
T
E
T
F
Q
I
------
P
K
E
L
P
P
G
P
L
Q
A
L
L
P
-----
L
K
--------
V
V
R
V
E
S
L
P
P
G
-
L
L
E
--
V
A
E
-
G
--
A
L
---
G
---
R
F
P
L
G
L
W
R
E
W
V
E
A
P
--
L
K
P
L
L
-
T
F
Q
D
G
---
K
G
A
-----------
L
Y
R
E
G
R
Y
L
Y
L
A
----------
A
W
P
S
-----
P
E
L
A
G
R
L
L
S
A
-----
L
------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.48
25%
-64
- C1 -
4UZS
8
?
A:
[19-538]
------------
R
L
W
Y
G
G
D
Y
N
P
D
Q
W
--
P
--
E
--
E
V
W
D
D
D
I
R
L
M
K
K
A
G
V
N
L
V
S
V
G
I
F
S
W
A
K
I
E
P
E
E
G
K
Y
D
F
D
W
L
---
D
R
A
I
D
K
L
G
K
A
G
I
A
V
D
L
A
S
A
T
A
S
P
P
M
W
L
T
Q
A
H
P
E
V
L
W
K
D
E
R
G
D
T
V
W
P
G
A
R
E
H
W
R
P
T
S
P
V
F
R
E
Y
A
L
N
L
C
R
R
M
A
E
H
Y
K
G
N
P
Y
V
V
A
W
H
V
S
N
E
Y
G
C
H
-
N
-
R
F
D
Y
S
D
D
A
M
R
A
F
Q
K
W
C
K
K
R
Y
K
-
T
-
I
D
A
V
N
E
A
W
G
T
A
F
W
A
Q
H
M
N
D
F
S
E
I
I
P
P
RYI-
G
D
G
N
---
F
------
M
N
P
G
K
L
L
D
-
Y
K
R
F
S
S
D
--------
A
L
K
E
L
Y
I
A
E
R
D
V
L
E
S
-
I
T
-
P
-
G
L
P
-
L
-------
T
-------
T
N
F
MVSA
G
G
S
M
-------
L
---
D
---
Y
D
D
--
W
G
A
E
V
D
F
V
S
N
D
H
Y
--------------------
F
--------
T
--
P
G
E
--------
A
H
F
----------------
D
------------------
E
V
A
-
Y
A
A
S
L
M
D
G
I
S
R
K
E
P
W
F
Q
M
E
H
S
T
S
-
A
--
V
--
N
W
R
P
I
N
Y
R
A
E
P
G
S
V
V
R
D
S
L
A
Q
V
A
M
G
A
D
A
I
C
Y
F
Q
W
R
Q
S
K
A
G
A
E
K
W
H
S
S
M
V
P
H
A
G
-
E
-
D
-
S
Q
I
F
R
D
V
C
E
L
G
A
D
L
G
R
L
S
D
E
G
----
L
M
G
T
K
T
V
-
K
S
K
V
A
V
V
F
D
Y
E
-------
S
Q
W
A
T
E
---
Y
T
--
A
N
---
P
--
T
-
Q
Q
-
V
D
H
W
T
E
P
L
D
---
W
F
R
A
L
A
D
N
G
I
T
A
D
V
V
P
V
R
S
D
W
D
S
Y
E
I
A
V
L
P
C
V
Y
L
L
S
E
E
T
S
R
R
V
R
E
F
V
A
N
G
G
K
L
F
V
T
Y
Y
T
G
L
S
D
E
N
D
H
I
------
W
L
G
G
Y
P
G
S
I
R
D
V
V
G
-----
V
R
--------
V
E
E
--
F
A
P
M
G
-
N
D
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.73
25%
-65
- C1 -
4UCF
3
?
A:
[19-542]
------------
R
L
W
Y
G
G
D
Y
N
P
D
Q
W
--
P
--
E
--
E
V
W
D
D
D
I
R
L
M
K
K
A
G
V
N
L
V
S
V
G
I
F
S
W
A
K
I
E
P
E
E
G
K
Y
D
F
D
W
L
---
D
R
A
I
D
K
L
G
K
A
G
I
A
V
D
L
A
S
A
T
A
S
P
P
M
W
L
T
Q
A
H
P
E
V
L
W
K
D
E
R
G
D
T
V
W
P
G
A
R
E
H
W
R
P
T
S
P
V
F
R
E
Y
A
L
N
L
C
R
R
M
A
E
H
Y
K
G
N
P
Y
V
V
A
W
H
V
S
N
E
Y
G
C
H
-
N
-
R
F
D
Y
S
D
D
A
M
R
A
F
Q
K
W
C
K
K
R
Y
K
-
T
-
I
D
A
V
N
E
A
W
G
T
A
F
W
A
Q
H
M
N
D
F
S
E
I
I
P
P
RYI-
G
D
G
N
---
F
------
M
N
P
G
K
L
L
D
-
Y
K
R
F
S
S
D
--------
A
L
K
E
L
Y
I
A
E
R
D
V
L
E
S
-
I
T
-
P
-
G
L
P
-
L
-------
T
-------
T
N
F
MVSA
G
G
S
M
-------
L
---
D
---
Y
D
D
--
W
G
A
E
V
D
F
V
S
N
D
H
Y
--------------------
F
--------
T
--
P
G
E
--------
A
H
F
----------------
D
------------------
E
V
A
-
Y
A
A
S
L
M
D
G
I
S
R
K
E
P
W
F
Q
M
E
H
S
T
S
-
A
--
V
--
N
W
R
P
I
N
Y
R
A
E
P
G
S
V
V
R
D
S
L
A
Q
V
A
M
G
A
D
A
I
C
Y
F
Q
W
R
Q
S
K
A
G
A
E
K
W
H
S
S
M
V
P
H
A
G
-
E
-
D
-
S
Q
I
F
R
D
V
C
E
L
G
A
D
L
G
R
L
S
D
E
G
----
L
M
G
T
K
T
V
-
K
S
K
V
A
V
V
F
D
Y
E
-------
S
Q
W
A
T
E
---
Y
T
--
A
N
---
P
--
T
-
Q
Q
-
V
D
H
W
T
E
P
L
D
---
W
F
R
A
L
A
D
N
G
I
T
A
D
V
V
P
V
R
S
D
W
D
S
Y
E
I
A
V
L
P
C
V
Y
L
L
S
E
E
T
S
R
R
V
R
E
F
V
A
N
G
G
K
L
F
V
T
Y
Y
T
G
L
S
D
E
N
D
H
I
------
W
L
G
G
Y
P
G
S
I
R
D
V
V
G
-----
V
R
--------
V
E
E
--
F
A
P
M
G
-
N
D
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
41.23
34%
-181
- C1 -
1VFF
-
?
A:
[50-118]
---------------------------------
E
L
Y
R
D
D
I
Q
L
M
T
S
L
G
Y
N
A
Y
R
F
S
-
I
E
W
S
R
L
F
P
E
E
N
K
F
N
E
D
A
F
M
K
Y
R
E
I
I
D
L
L
L
T
R
G
I
T
P
L
V
T
L
H
H
F
T
S
P
L
W
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------