@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu07320: (2016-06-11 )
MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMFPILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILGLAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENTAITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGAIGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLGILAFLLPSDQKLREWHS
Atome Classification :
(20 SA)
-----------------------.........-10....----....20........30.------.......40...--...--..------50---.--------.--------------.......60........70........80-----------..-.-.--.....90.---......----------.100----..----.------------------.-----.----.--------.110----..---.......120-...----.-------.-..130..---...-------.-.--140.......150-----------------.......160---------------....-----------------....--.--------------------------170------------......-------------...--180...--..-...-190.-....-----.-..200-----..---.---...-..-------.---------------210-----.----..----.-----------------------------------------------.---..-----------------------------------------------------..220.---..------.--....----------------------230----..----.-.....--240---..-----.......250-----------.....-.---..260--.----..----------..---....270.-----------------......---280---.......-----290..------...--..300-.........-310-----.-.-----------.-----.----.----....----320...--------..--------..-330..-------......340.-----------------.-..-.-..350...------....360-.......-370...----..-..380--------........390..-....------.400.......-----------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------MAIAAPL
K
E
-
K
TVQKP----G
T
T
V
Y
P
I
L
I
I
I
G
I
C
H
M
L
------
N
D
S
L
Q
A
V
I
P
A
M
F
--
P
I
L
--
E
R
------S----M--------S--------------
L
T
F
TQL
G
I
I
A
F
T
L
N
M
V
S
S
V
M
Q
P
V
V
G
W
YT------------DK-R-P--RPYALP
V
G
---
L
T
A
S
M
L
----------
G
I
L
G
----
L
A
----
F
------------------
A
-----
P
----
S
--------
F
I
------
T
I
---
L
C
C
V
F
F
I
G
L
G
-
S
A
I----F-------H-PEG
S
R
V
A
---
Y
M
A-------A-G--TK
R
G
L
A
Q
S
I
Y
Q
VG-----------------GNSG
Q
A
M
A
-----------------
P
L
I
T
-----------------
A
L
I
L
--
V
--------------------------P--------------LGQ
F
G
A
-------------
V
W
F
--
T
L
-
V
A
A
--
L
A
-
V
M
F
-
L
-
M
Y
-
I
A
K
W
-----
Y
-
A
S
R
-------
L
G
---
S
---
L
A
Q
-KS-------G---------------K-------Q----KK----T-----------------------------------------------A---E
N
-----------------------------------------------------
T
A
I
T
-
K
---
S
V
------
V
--
S
A
L
I
----------------------
I
I
-----
I
F
----
L
-
I
F
A
R
S
--
W
-----
Y
T
-----
S
A
IGN
F
Y
T
F
------------
Y
A
M
D
T
-
Y
---
H
V
S
----
I
----
Q
Q
----------
A
Q
---
S
Y
I
F
V
F
L
L
-----------------
F
G
A
I
G
T
---FLG---
G
P
L
A
D
R
F-----G
K
R
F
V
------
I
L
G
--
S
L
L
---CSA
P
L
A
I
V
L-P-------F-A-----------
G
-----
P
----
V
----
L
A
Y
G
----
V
L
A
L
I
G
--------
L
V
--------
L
M
-S-SF
S
-------
V
T
V
V
Y
A
Q
ELV-----------------P-GK-I-GTMSG
L
T
V
------
G
L
A
F
G
M
G
-
A
I
G
A
V
A
L
-
G
A
L
I
DA----AG-L
T
P
T
---------
M
I
A
I
A
F
L
P
V
L
G
I
L
-
A
F
LL------PS
D
Q
K
L
R
E
WHS-----------------------------------------------------------------
5
HHSearch
76.58
18%
-180
- C4 -
1PW4
-
GLPT_ECOLI
A:
[8-429]
--------------------------
A
P
H
K
A
R
-
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
------
Y
Y
L
V
R
K
N
F
A
L
A
M
--
P
Y
L
--
V
-------
E
----
Q
--------
G
--------------
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
------------
D
R
-
S
-
N
--
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
----------
V
M
L
F
----
M
G
----
F
------------------
V
-----
P
W
A
T
S
S
--------
I
A
------
V
M
---
F
V
L
L
F
L
C
G
W
F
-
Q
G
M
----
G
-------
W
-
P
P
C
G
R
T
M
---
V
H
W
-------
W
S
Q
--
K
E
R
G
G
I
V
S
V
W
N
C
A
-----------------
H
N
V
G
G
G
I
P
-----------------
P
L
L
F
-----------------
L
L
G
M
--
A
W-------------------------
F
--------------
N
D
W
H
A
A
-------------
L
Y
M
--
P
A
F
C
A
I
--
L
V
-
A
L
F
-
A
-
F
A
-
M
M
R
D
-----
T
-
P
Q
S
-------
C
G
---
L
PPI
E
E
Y
-
K
N
-------
D
--------------------------------------------------------------------------------------
T
A
-----------------------------------------------------
K
Q
I
F
M
Q
---
Y
V
------
L
PN
K
L
L
W
----------------------
Y
I
-----
A
I
----
A
-
N
V
F
V
Y
--
L
-----
L
R
-----
Y
G
I
L
D
W
S
P
T
------------
Y
L
K
E
V
-
K
---
H
F
A
----
L
----
D
K
----------
S
S
---
W
A
Y
F
L
Y
E
Y
-----------------
A
G
I
P
G
T
---
L
L
C
---
G
W
M
S
D
K
V
-----
F
R
G
N
R
------
G
A
T
--
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
-
W
-------
M
-
N
PA---------
G
-----
N
P
---
T
----
V
D
M
I
----
C
M
I
V
I
G
--------
F
L
--------
I
Y
-
G
-
P
V
M
-------
L
I
G
L
H
A
L
E
L
A
-----------------
P
-
K
K
-
A
A
G
T
A
A
G
F
T
G
------
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
-
G
Y
T
V
D
F
----
F
G
-
W
D
G
G
---------
F
M
V
M
I
G
G
S
I
L
A
V
I
---------------------------------------------------------------------------------------
28
Fugue
72.91
16%
-182
- C4 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-------------------FKPA
P
H
K
A
R
L
P
A
A
-
E
I
D
P
T
Y
----
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
------
Y
Y
L
V
R
K
N
F
A
L
A
M
--
P
Y
L
---
V
------
E
----
Q
--------
G
--------------
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
------------
D
R
-
S
-
N
--
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
----------
V
M
L
F
----
M
G
F
V
P
W
A
------------------
T
-----
S
----
S
--------
I
A
------
V
M
---
F
V
L
L
F
L
C
G
W
F
-
Q
G
M
----
G
-------
W
-
P
P
C
G
R
T
M
V
--
H
W
W
-------
S
-
Q
--
K
E
R
G
G
I
V
S
V
W
N
C
A
-----------------
H
N
V
G
G
G
I
P
-----------------
P
L
L
F
-----------------
L
L
G
M
--
A
--------------------------
W
--------------
F
N
D
W
H
A
-------------
A
L
Y
--
M
P
-
A
F
C
--
A
I
-
L
V
A
-
L
-
F
A
-
F
A
M
M
-----
R
-
D
T
P
-------
Q
S
---
C
---
G
L
P
-
P
I
-------
E
---------------
E
-------
Y
----
K
N
----
D
-----------------------------------------------
T
---
A
K
-----------------------------------------------------
Q
I
F
M
-
Q
---
Y
V
------
L
PN
K
L
L
W
----------------------
Y
I
-----
A
I
----
A
-
N
V
F
V
Y
--
L
-----
L
R
-----
Y
G
I
L
D
W
S
P
T
------------
Y
L
K
E
V
-
K
---
H
F
A
----
L
----
D
K
----------
S
S
---
W
A
Y
F
L
Y
E
Y
-----------------
A
G
I
P
G
T
---
L
L
C
---
G
W
M
S
D
K
V
FR---
G
N
R
G
A
------
T
G
V
--
F
F
M
---
T
L
V
T
I
A
T
I
V
-
Y
-------
W
-
M
-----------
N
-----
P
AGN
P
T
----
V
D
M
I
----
C
M
I
V
I
G
--------
F
L
--------
I
Y
-
G
-
P
V
M
-------
L
I
G
L
H
A
L
E
L
A
-----------------
P
K
K
A
-
A
-
G
T
A
A
G
F
T
G
------
L
F
G
Y
L
G
G
-
S
V
A
A
S
A
I
-
V
G
Y
T
V
D
FFG
W
D
G
-
G
F
M
V
---------
M
I
G
G
S
I
L
A
V
I
L
L
I
-
V
V
M
I
------
G
E
K
R
R
H
E
Q
L
L
Q
ELVP-------------------------------------------------------------
32
Fugue
71.47
17%
-178
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[22-435]
---------------------------------
R
S
Y
I
I
P
----
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
------
N
D
I
L
L
P
Q
F
Q
Q
A
F
-----------------------------
T
--------------
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
------------
K
K
-
L
-
S
--
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
----------
G
A
A
L
----
F
W
----
P
------------------
A
-----
A
E
I
M-
N
--------
Y
T
------
L
F
---
L
V
G
L
F
I
I
A
A
G
-
L
G
C
----
L
----------
E
T
A
A
N
P
---
F
V
T
V
LGPESS
G
-
H
--
F
R
L
N
L
A
Q
T
F
N
S
F
G
-----------------
A
I
I
A
V
V
F
G
-----------------
Q
S
L
I
LSNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
--
A
--------------------------
Y
--------------
K
H
S
L
V
L
-------------
S
V
Q
--
T
P
-
Y
M
I
--
I
V
-
A
I
V
-
L
-
L
V
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A
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L
I
-----
M
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L
T
K
-------
F
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---
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---
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Q
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N
-------
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---------------
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-------
D
----
A
K
----
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-----------------------------------------------
G
---
S
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-----------------------------------------------------
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A
S
L
-
S
---
R
L
------
A
RI
R
H
W
R
----------------------
W
A
-----
V
L
----
A
-
Q
F
C
Y
V
--
G
-----
A
Q
-----
T
A
C
W
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Y
L
I
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------------
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A
V
E
E
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M
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----
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----
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F
----------
A
A
---
N
Y
L
T
G
T
M
V
-----------------
C
F
F
I
G
R
---
F
T
G
---
T
W
L
I
S
R
F
-----
A
P
H
K
V
------
L
A
A
--
Y
A
L
---
I
A
M
A
L
C
L
I
S
-
A
-------
F
-
A
-----------
G
-----
G
----
H
----
V
G
L
I
----
A
L
T
L
C
S
--------
A
F
--------
M
S
-
I
-
Q
Y
P
-------
T
I
F
S
L
G
I
K
N
L
-------------------
G
Q
-
D
-
T
K
Y
G
S
S
F
I
------
V
M
T
I
I
G
G
-
G
I
V
T
P
V
M
-
G
F
V
S
D
A
----
A
G
-
N
I
P
T
---------
A
E
L
I
P
A
L
C
F
A
V
I
F
-
I
F
A
R
------
F
R
S
Q
T
-----------------------------------------------------------------------
36
Fugue
70.27
20%
-151
* C4 *
5AYN
10
?
A:
[7-426]
-----------------------
L
R
I
E
T
Q
L
L
L
G
R
L
L
T
R
S
----
G
D
Q
A
W
D
F
V
V
P
F
A
L
L
V
I
F
------
P
G
K
L
Q
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A
A
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Y
L
--
I
V
K
--
I
G
------
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----
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--------
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--------------
L
T
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S
S
G
K
W
I
-------------------------------
D
T
-
H
-
P
--
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I
Q
V
V
K
W
G
---
V
W
L
Q
F
F
----------
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A
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V
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----
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------------------
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-----
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----
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--------
L
V
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A
GGRE
S
W
---
L
L
S
V
L
F
I
A
L
A
L
S
G
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----
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-------
A
-
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L
G
S
Q
I
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---
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I
S
-------
V
-
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--
N
--
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L
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----------------------
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L
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-----------------
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N
S
-----------------
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L
R
R
--
I
--------------------------
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--------------
L
A
T
E
V
G
-------------
A
P
I
--
L
A
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A
L
--
F
P
-
L
A
G
-
L
-
F
L
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I
G
L
W
-----
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-
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F
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Y
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L
L
R
---
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---
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-------
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---------------
L
-------
K
----
I
K
----
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-----------------------------------------------
L
---
T
E
-----------------------------------------------------
A
I
N
L
-
R
---
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S
------
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--
S
D
P
I
----------------------
F
W
-----
L
I
----
L
-
S
Y
A
L
L
--
W
-----
L
S
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S
P
H
G
V
L
L
A
A
------------
Y
L
K
D
E
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M
---
R
L
P
----
E
----
T
E
----------
I
G
---
L
F
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G
L
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-----------------
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G
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---
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S
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---
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Y
L
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L
-----
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---
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------
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--
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R
W
---
H
L
G
F
Q
G
V
T
L
-
G
-------
I
-
A
-----------
V
-----
T
----
A
----
F
A
M
G
STAS
V
Y
V
F
L
G
--------
C
I
--------
L
L
-
S
-
R
V
G
-------
L
Y
G
F
S
N
G
E
F
E
-----------------
L
-
R
Q
-
R
-
L
I
P
E
G
R
R
G
------
E
L
N
S
L
S
S
-
L
T
T
T
S
A
T
-
L
I
L
F
S
A
----
G
S
-
L
L
P
Q
---------
T
E
D
F
K
Y
L
V
Y
V
S
L
A
-
A
V
L
L
-------
A
N
V
V
F
I
K
W
S
S
R----------------------------------------------------------------
14
HHSearch
68.76
16%
-163
- C4 -
4J05
1
?
A:
[36-508]
-------------------------------------------------
L
V
L
L
A
G
V
G
F
F
L
------
D
A
Y
D
L
F
I
I
N
Q
V
A
--
P
M
L
--
A
Q
------
V
YFPK
T
--------
G
--------------
L
P
A
Q
R
Q
D
L
M
K
A
A
A
N
I
G
C
V
V
G
Q
V
M
F
G
V
L
G
------------
D
S
-
F
-
G
--
R
K
F
V
Y
G
K
E
---
L
I
L
I
I
V
----------
A
T
I
F
----
Q
M
----
S
------------------
A
-----
P
----
S
HWD
G
N
R
V
-
L
T
------
W
I
---
T
I
C
R
V
F
L
G
I
G
-
I
G
G
----
D
-------
Y
-
P
M
S
A
T
V
V
---
S
D
R
-------
A
N
I
--
H
R
R
G
T
L
L
C
F
I
F
A
N
-----------------
Q
G
W
G
S
F
V
G
-----------------
S
L
V
T
-----------------
I
V
T
I
--
S
--------------------------
G
F
K
H
RLKSGHTHD
V
D
K
A
W
R
I
L
-------------
I
G
L
--
S
L
-
I
P
A
--
F
G
-
T
L
Y
-
Q
-
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-
Q
E
F
V
A
Y
F
STWNH
F
--
R
N
L
L
----------------------
G
S
-----
M
L
----
G
-
W
F
L
V
D
--
I
-----
A
F
-----
Y
G
I
N
L
N
Q
S
V
------------
V
L
A
Q
--
I
---
G
F
A
----
G
----
K
T
GD
V
Y
D
K
L
F
Q
L
A
T
---
G
N
I
I
V
T
A
L
-----------------
G
F
L
P
G
Y
---
Y
F
T
---
L
F
L
I
D
I
V
-----
G
R
K
K
L
------
Q
F
M
--
G
F
I
---
M
S
G
L
F
L
A
I
L
-
A
-------
G
E
I
-----------
D
HI---
G
K
G
--
P
----
L
L
A
C
----
F
T
F
M
Q
F
--------
F
F
--------
N
F
-
G
-
A
N
T
-------
T
T
F
I
V
A
A
E
L
F
-----------------
P
-
T
R
-
I
R
A
S
A
H
G
I
S
A
------
A
A
G
K
C
G
A
-
I
L
S
S
L
V
F
-
N
Q
L
K
A
K
----
I
G
-
T
S
A
V
---------
L
W
I
F
F
S
T
C
I
L
G
F
I
S
T
F
L
I
------
D
E
T
M
G
V
D
---------------------------------------------------------------------
34
Fugue
62.85
19%
-163
- C4 -
4IKW
20
?
A:
[3-494]
-------------------SID
K
Q
Q
I
A
A
S
V
P
Q
-
R
G
F
F
G
H
----
P
K
G
L
F
T
L
F
F
T
E
F
W
E
R
F
S
------
Y
Y
G
M
R
A
I
L
V
Y
Y
M
YY
E
V
S
--
K
G
------
G
----
L
--------
G
--------------
L
D
-
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
------------
A
D
-
R
-
V
FG
T
S
R
A
V
F
Y
G
---
G
L
L
I
M
A
----------
G
H
I
A
----
L
A
----
I
------------------
P
-----
G
----
G
--------
V
A
------
A
L
---
F
V
S
M
A
L
I
V
L
G
-
T
G
L
----
L
-------
K
-
P
N
V
S
S
I
V
G
D
M
Y
K
P
-------
G
-
D
--
D
R
R
D
A
G
F
S
I
F
Y
M
G
-----------------
I
N
L
G
A
F
L
A
-----------------
P
L
V
V
-----------------
G
T
A
G
--
M
--------------------------
K
YN
F
-----------
H
L
G
F
G
L
-------------
A
A
V
--
G
M
-
F
L
G
--
L
V
-
V
F
V
-
A
-
T
R
-
K
K
N
L
GLAGT
Y
-
V
P
N
-------
P
L
---
T
---
P
A
E
-
K
K
-------
K
---------------
A
-------
A
----
A
I
----
M
-----------------------------------------------
A
---
V
G
-----------------------------------------------------
A
V
V
I
-
A
---
V
L
------
L
--
A
I
L
I
P
NGWFT
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
-----
Y
F
----
V
-
V
M
Y
R
S
--
P
-----
K
T
T
A
E
E
R
S
R
V
I
A
Y
I
P
L
------------
F
V
A
S
A
-
M
---
F
W
A
----
I
----
Q
E
----------
Q
G
---
S
T
I
L
A
N
Y
A
D
KRTQLDVAG
I
H
L
S
PAW
F
Q
S
L
N
P
---
L
F
I
---
I
I
L
A
P
V
F
-----
A
W
M
W
V
------
K
L
G
--
K
R
Q
---
P
T
I
P
Q
K
F
A
L
-
G
-------
L
-
L
-----------
F
-----
A
----
G
----
L
S
F
I
----
V
I
L
V
P
G
--------
H
L
S
GGGLVHP
I
W
-
L
-
V
L
S
-------
Y
F
I
V
V
L
G
E
L
C
-----------------
L
-
S
P
-
V
-
G
L
S
A
T
T
K
L
APAAFS
A
Q
T
M
S
L
W
-
F
L
S
N
A
A
A
-
Q
A
I
N
A
Q
----
L
V
-
R
F
Y
T
PENETA
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
-
L
A
I
A
------
P
R
I
G
R
L
M
K
G
-------------------------------------------------------------------
9
HHSearch
62.67
16%
-169
- C4 -
4LDS
-
?
A:
[7-414]
------------------------------------------------
L
I
F
I
L
G
A
L
G
G
L
L
------
Y
G
Y
D
N
G
V
I
S
G
A
L
--
L
F
I
--
H
K
------
D
----
I
--------
P
--------------
L
N
S
T
T
E
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
------------
D
K
-
L
-
G
--
R
R
R
L
V
M
L
I
---
A
I
V
F
I
I
----------
G
A
L
I
----
L
A
----
A
------------------
S
-----
T
----
N
--------
L
A
------
L
L
---
I
I
G
R
L
I
I
G
L
A
-
V
G
G
----
S
-------
M
-
S
T
V
P
V
Y
L
---
S
E
M
-------
A
P
T
--
E
Y
R
G
S
L
G
S
L
N
Q
L
M
-----------------
I
T
I
G
I
L
A
A
-----------------
Y
L
V
N
-----------------
Y
A
F
A
--
D
--------------------------
I
--------------
E
G
W
R
W
M
-------------
L
G
L
--
A
V
-
V
P
S
--
V
I
-
L
L
V
-
G
-
I
Y
-
F
M
P
E
-----
S
-
P
R
W
-------
L
L
---
E
N
RN
E
E
A
-
A
R
Q
V
M
K
I
T
Y
D
---------------
D
-------
S
E
I
D
-
K
E
----
L
K
E
M
--------------------------------------------
K
E
I
N
A
I
-----------------------------------------------------
S
E
S
T
-
W
---
T
V
------
I
KS
P
W
L
G
----------------------
R
I
-----
L
I
V
G
C
I
F
-
A
I
F
Q
Q
--
F
I
----
G
I
-----
N
A
V
I
F
Y
S
S
S
------------
I
F
-
A
K
-
A
---
G
L
G
----
E
----
A
A
----------
S
I
---
L
G
S
V
G
I
G
T
-----------------
I
N
V
L
V
T
---
I
V
A
---
I
F
V
V
D
K
I
-----
D
R
K
K
L
------
L
V
G
--
G
N
I
---
G
M
I
A
S
L
L
I
M
-
A
I
L
I
W
T
IG
I
-
A
-----------
S
-----
S
A
---
W
----
I
I
I
V
----
C
L
S
L
F
I
--------
V
F
--------
F
G
-
I
S
W
G
P
-------
V
L
W
V
M
L
P
E
L
F
-----------------
P
-
M
R
-
A
R
G
A
A
T
G
I
S
A
------
L
V
L
N
I
G
T
-
L
I
V
S
L
F
F
-
P
I
L
S
D
A
----
L
S
-
T
E
W
V
---------
F
L
I
F
A
F
I
G
V
L
A
-----------------------------------------------------------------------------------------
30
Fugue
60.66
14%
-164
- C4 -
4IU9
-
NARU_ECOLI
A:
[12-454]
----------------------L
L
R
D
W
K
P
E
N
P
-
A
F
W
E
N
K
----
G
K
H
I
A
R
R
N
L
W
I
S
V
S
C
L
L
------
L
A
F
C
V
W
M
L
F
S
A
V
--
T
V
N
L
N
K
I
------
G
----
F
--------
N
--------------
F
T
T
D
Q
L
F
L
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
------------
P
I
-
F
-
G
--
G
R
R
W
T
V
F
S
---
T
A
I
L
I
I
----------
P
C
V
W
----
L
G
----
I
------------------
A
V
Q
N
PN
T
----
P
--------
F
G
------
I
F
---
I
V
I
A
L
L
C
G
F
A
-
G
A
N
----
F
-------
A
-
S
S
M
G
N
I
S
---
F
F
F
-------
P
-
K
--
A
K
Q
G
S
A
L
G
I
N
G
G
L
-----------------
G
N
L
G
V
S
V
M
-----------------
Q
L
V
A
-----------------
P
L
V
I
--
F
--------------------------
V
PV------------
F
A
F
L
G
V
-------------
N
G
V
--
P
Q
-
A
D
G
---
S
-
V
M
S
-
L
-
A
N
-
A
A
W
I
-----
W
-
V
P
L
-------
L
A
---
I
---
A
T
I
-
A
A
-------
W
---------------
S
-------
G
--------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
I
A
----------------------
L
W
-----
L
L
----
S
-
L
L
Y
L
A
--
T
-----
F
G
-----
S
F
I
G
F
S
A
G
F
------------
A
M
L
A
K
-
T
---
Q
F
P
----
D
----
V
N
----------
I
L
---
R
L
A
F
F
G
P
F
-----------------
I
G
A
I
A
R
---
S
V
G
---
G
A
I
S
D
K
F
-----
G
G
V
R
V
------
T
L
I
--
N
F
I
---
F
M
A
I
F
S
A
L
L
-
F
-------
L
-------------------
T
----
L
----
P
G
T
G
----
S
G
N
F
I
A
--------
F
Y
A-------
V
F
-
M
-
G
L
F
-------
L
T
A
G
L
G
S
G
S
T
-----------------
F
-
Q
M
-
I
-
A
V
I
L
G
F
I
S
------
A
I
G
A
V
G
G
-
F
F
I
P
Q
A
F
-
G
M
S
L
N
M
----
T
G
------------------
S
P
V
G
A
M
K
V
F
-
L
I
F
Y
------
I
V
C
V
L
L
T
W
L
V
Y
-----------------------------------------------------------------
6
HHSearch
60.56
16%
-162
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[34-423]
--------------------------------------------------------
L
F
F
L
------
W
A
V
A
N
N
L
N
D
I
L
L
--
P
Q
F
--
Q
Q
------
A
----
F
--------
T
--------------
L
T
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
------------
K
K
-
L
-
S
--
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
----------
G
A
A
L
----
F
W
----
P
------------------
A
A
E
I
--
M
----
N
--------
Y
T
------
L
F
---
L
V
G
L
F
I
I
A
A
G
-
L
G
C
----
L
-------
E
-
T
A
A
N
P
F
V
---
T
V
L
-------
G
P
E
--
S
S
G
H
F
R
L
N
L
A
Q
T
F
-----------------
N
S
F
G
A
I
I
A
-----------------
V
V
F
G
-----------------
Q
S
L
I
--
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
--------------
L
S
V
Q
T
P
-------------
Y
M
I
I
-
V
A
-
I
V
L
--
L
V
-
A
L
L
-
I
M
L
T
-
K
F
P
A
-----
L
-
Q
S
D
-------
N
H
---
S
-----
D
--
A
-------------------------------------
K
----
Q
-----------------------------------------------
G
---
S
F
-----------------------------------------------------
S
A
S
L
-
S
---
R
L
------
A
RI
R
H
W
R
----------------------
W
A
-----
V
L
----
A
-
Q
F
C
Y
V
--
G
-----
A
Q
-----
T
A
C
W
S
Y
L
I
R
------------
Y
A
V
E
E
I
P
---
G
M
T
----
A
----
G
F
----------
A
A
---
N
Y
L
T
G
T
M
V
-----------------
C
F
F
I
G
R
---
F
T
G
---
T
W
L
I
S
R
F
-----
A
P
H
K
V
------
L
A
A
--
Y
A
L
---
I
A
M
A
L
C
L
I
S
-
A
-------
F
-
A
-----------
G
-----
G
----
H
----
V
G
L
I
----
A
L
T
L
C
S
--------
A
F
--------
M
S
-
I
-
Q
Y
P
-------
T
I
F
S
L
G
I
K
N
L
-----------------
G
-
Q
D
-
T
-
K
Y
G
S
S
F
I
-------
V
M
T
I
I
G
G
-
G
I
V
T
P
V
M
-
G
F
V
S
D
A
----
A
G
N
I
P
T
A
---------
E
L
I
P
A
L
C
F
A
-------------------------------------------------------------------------------------------
12
HHSearch
58.88
15%
-174
- C4 -
4IKV
11
?
A:
[21-479]
----------------------------------------------
H
P
K
G
L
F
T
L
F
F
T
E
F
W
------
E
R
F
S
Y
Y
G
M
R
A
I
L
--
V
Y
Y
--
M
Y
YEVSKG
G
----
L
--------
G
--------------
L
D
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
W
L
A
------------
D
R
V
F
-
G
--
T
S
R
A
V
F
Y
G
---
G
L
L
I
M
A
----------
G
H
I
A
----
L
A
----
I
------------------
P
-----
G
----
G
--------
V
A
------
A
L
---
F
V
S
M
A
L
I
V
L
G
-
T
G
L
----
L
-------
K
-
P
N
V
S
S
I
V
---
G
D
M
-------
Y
K
P
GD
D
R
R
D
A
G
F
S
I
F
Y
M
G
-----------------
I
N
L
G
A
F
L
A
-----------------
P
L
V
V
-----------------
G
T
A
G
--
M
--------------------------
K
--------------
Y
N
F
H
L
G
-------------
F
G
L
--
A
A
-
V
G
M
--
F
L
-
G
L
V
-
V
-
F
V
-
A
T
R
K
-----
K
N
L
G
L
-------
A
G
TYV
P
---
N
P
L
-
T
P
-------
A
---------------
E
-------
K
----
K
K
----
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
GWFT
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
R
-
S
P
-----------------------------------------------------
K
T
T
A
-
E
---
E
R
------
S
R
V
I
A
Y
I
----------------------
P
L
-----
F
V
----
A
-
S
A
M
F
W
--
A
-----
I
Q
-----
E
Q
G
S
T
I
L
A
N
------------
Y
A
D
K
R
-
T
---
Q
L
D
----
V
AG
I
H
L
S
----------
P
A
---
W
F
Q
S
L
N
P
L
-----------------
F
I
I
I
L
A
---
P
V
F
---
A
W
M
W
V
K
L
-----
G
K
R
Q
P
T
I
P
Q
K
-
F
A
L
--
G
L
L
---
F
A
G
L
S
F
I
V
I
-
L
-------
V
-
P
G
H
L
S
GGGL---
V
-----
H
P---
I
----
W
L
V
L
----
S
Y
F
I
V
V
--------
L
G
--------
E
L
-
C
-
L
S
P
-------
V
G
L
S
A
T
T
K
L
A
-----------------
P
-
A
A
-
F
S
A
Q
T
M
S
L
W
F
------
L
S
N
A
A
A
Q
-
A
I
N
A
Q
L
V
-
R
F
Y
T
P
E
-----
N
-
E
T
A
Y
---------
F
G
T
I
G
G
A
A
L
V
L
G
L
---------------------------------------------------------------------------------------
19
HHSearch
58.36
13%
-175
- C4 -
3WDO
-
?
A:
[14-383]
--------------------------------------------------
T
W
G
L
G
T
V
F
S
L
------
R
M
L
G
M
F
M
V
L
P
V
L
--
T
T
Y
--
G
M
A-----
L
----
Q
--------
G
--------------
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
------------
D
R
-
I
-
G
--
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
----------
G
S
V
I
----
A
A
----
L
------------------
S
-----
D
----
S
--------
I
W
------
G
I
---
I
L
G
R
A
L
Q
G
S
G
-
A
------
I
-------
A
-
A
A
V
M
A
L
L
---
S
D
L
-------
T
R
E
--
Q
N
R
T
K
A
M
A
F
I
G
V
S
-----------------
F
G
I
T
F
A
I
A
-----------------
M
V
L
G
-----------------
P
I
I
T
--
H
--------------------------
K
--------------
L
G
L
H
A
L
-------------
F
W
M
--
I
A
-
I
L
A
--
T
T
G
I
A
L
-
T
-
I
W
-
V
V
P
N
-----
S
-
S
T
H
-------
V
L
---
N
---
R
E
S
--
G
-------
M
-----------------------------
V
----
K
-----------------------------------------------
G
---
S
F
-----------------------------------------------------
S
K
V
L
-
A
---
E
----------
P
R
L
L
----------------------
K
L
-----
N
F
----
G
-
I
M
C
L
H
--
M
-----
L
L
-----
M
S
T
F
V
A
L
P
G
------------
Q
L
A
D
--
A
---
G
F
P
----
A
----
A
E
----------
H
W
K
V
Y
L
A
T
M
L
I
A
F
-----------------
G
S
V
V
P
F
---
I
I
Y
---
A
E
V
K
R
K
M
-----
K
Q
--
V
------
F
V
F
--
C
V
G
---
L
I
V
V
A
E
I
V
L
-
W
N
------
A
-
Q
-----------
T
-----
Q
F
---
W
----
Q
L
V
V
----
G
V
Q
L
F
F
--------
V
A
--------
F
N
-
L
-
M
E
A
-------
L
L
P
S
L
I
S
K
E
S
-----------------
P
-
A
G
-
Y
K
G
T
A
M
G
V
Y
S
------
T
S
Q
F
L
G
V
-
A
I
G
G
S
L
G
-
G
W
I
D
G
M
----
F
D
-
G
Q
G
V
---------
F
L
A
G
A
M
L
A
A
V
W
L
A
---------------------------------------------------------------------------------------
11
HHSearch
58.28
17%
-173
- C4 -
4U4V
7
NARK_ECOLI
A:
[55-451]
-------------------------------------------------------------------------
F
S
A
V
A
--
V
N
L
P-
K
V
------
G
----
F
--------
N
--------------
F
T
T
D
Q
L
F
M
L
T
A
L
P
S
V
S
G
A
L
L
R
V
P
Y
S
F
M
V
------------
P
I
-
F
-
G
--
G
R
R
W
T
A
F
S
---
T
G
I
L
I
I
----------
P
C
V
W
----
L
G
----
F
------------------
A
V
Q
D
TS
T
----
P
--------
Y
S
------
V
F
---
I
I
I
S
L
L
C
G
F
A
-
G
A
-----
N
-------
F
-
A
S
S
M
A
N
I
---
S
F
F
-------
F
P
K
--
Q
K
Q
G
G
A
L
G
L
N
G
G
L
-----------------
G
N
M
G
V
S
V
M
-----------------
Q
L
V
A
-----------------
P
L
V
V
--
S
LSIFA---------------------
V
--------------
F
G
S
Q
G
V
K
Q
PDGTELY
L
A
N
A
S
W
I
--
W
V
P
F
L
A
--
I
F
-
T
I
A
-
A
-
W
F
-
G
M
N
D
-----
L
-
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
L
-
K
---
R
----------
G
H
L
W
----------------------
I
M
-----
S
L
----
L
-
Y
L
A
T
F
--
G
-----
S
F
-----
I
G
F
S
A
G
F
A
M
------------
L
S
K
---
T
---
Q
F
P
----
D
----
V
Q
----------
I
L
---
Q
Y
A
F
F
G
P
F
-----------------
I
G
A
L
A
R
---
S
A
G
---
G
A
L
S
D
R
L
-----
G
G
T
R
V
------
T
L
V
--
N
F
I
---
L
M
A
I
F
S
G
L
L
-
F
-------
L
-
T
L----------
P
TDQGG
S
F
---
M
A
F
F
A
V
F
L
A
----
L
F
L
T
A
G
--------
L
G
--------
S
G
-
S
-
T
F
Q
-------
M
I
S
V
I
F
R
K
L
T
M
D
R
V
K
A
E
GGS
D
E
R
A
M
R
E
A
-
A
T
-
D
T
A
A
A
L
G
F
I
S
------
A
I
G
A
I
G
G
-
F
F
I
P
K
A
F
-
G
S
S
L
A
L
----
T
G
S
P
V
G
A
---------
M
K
V
F
L
I
F
Y
I
A
C
V
V
---------------------------------------------------------------------------------------
13
HHSearch
57.05
15%
-171
- C4 -
4W6V
-
?
A:
[16-489]
----------------------------------------------
H
P
Y
P
L
S
G
L
F
L
S
E
M
W
------
E
R
F
S
F
Y
G
I
R
P
L
L
--
I
L
F
--
M
A
ATVFDG
G
----
M
--------
G
--------------
L
P
R
E
Q
A
S
A
I
V
G
I
F
A
G
S
M
Y
L
A
A
L
P
G
G
L
L
A
------------
D
N
-
W
L
G
--
Q
Q
R
A
V
W
Y
G
---
S
I
L
I
A
L
----------
G
H
L
S
----
I
A
----
L
------------------
S
-----
A
FF--
G
--------
N
D
------
L
F
---
F
I
G
L
V
F
I
V
L
G
-
T
G
L
----
F
-------
K
-
T
C
I
S
V
M
V
---
G
T
L
-------
Y
K
P
GD
A
R
R
D
G
G
F
S
L
F
Y
M
G
-----------------
I
N
M
G
S
F
I
A
-----------------
P
L
L
S
-----------------
G
W
L
L
--
R
--------------------------
T
--------------
H
G
W
H
W
G
-------------
F
G
I
--
G
G
-
I
G
M
--
L
V
-
A
L
L
I
F
-
R
G
F
A
I
P
A
-----
M
-
K
R
Y
-------
D
A
---
E
---
V
G
L
-
D
S
-------
S
---------------
W
-------
N
----
K
P
T---------------------------------------------------------G
R
W
V
T
A
I
M
A
V
V
V
V
I
I
A
L
I
S
Q
G
V
I
P
I
N
P
V
M
I
A
S
L
L
V
Y
V
I
A
A
S
V
T
L
Y
F
I
Y
L
F
A
F
A
K
M
S
R
-
K
---
D
R
------
A
R
L
L
V
C
F
----------------------
I
L
-----
L
V
----
S
-
A
A
F
F
W
--
S
-----
A
F
-----
E
Q
K
P
T
S
F
N
L
------------
F
A
N
D
Y
-
T
---
D
R
M
VMGF
E
----
I
P
----------
T
V
---
W
F
Q
S
I
N
A
L
-----------------
F
I
I
L
L
A
---
P
V
F
---
S
W
A
--------------PS
S
I
T
K
F
V
I
--
G
I
L
---
C
A
A
A
G
F
A
V
M
-
M
-------
Y
-
A
A
Q
H
V
L
S
S
G
GAG
V
-----
S
P---
L
----
W
L
V
M
----
S
I
L
L
L
T
--------
L
G
--------
E
L
-
C
-
L
S
P
-------
I
G
L
A
T
M
T
L
L
A
-----------------
P
-
D
R
-
M
R
G
Q
V
M
G
L
W
F
------
C
A
S
S
L
G
N
-
L
A
A
G
L
I
G
-
G
H
V
K
A
D
QL--
D
M
-
L
P
T
L
---------
F
A
R
C
S
I
A
L
V
I
C
A
A
---------------------------------------------------------------------------------------
25
HHSearch
56.97
14%
-186
- C4 -
2CFQ
5
LACY_ECOLI
A:
[8-394]
-------------------------------------------------
N
F
W
M
F
G
L
F
F
F
F
------
Y
F
F
I
M
G
A
Y
F
P
F
F
--
P
I
W
--
L
H
------
D
I---
N
--------
H
--------------
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
------------
D
K
-
L
-
G
--
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
----------
P
F
F
I
----
F
I
----
F
------------------
G
-----
P
----
L
L
-------
Q
Y
------
N
I
---
L
V
G
S
I
V
G
G
I
Y
-
L
G
F
CFNA
G
-------
A
-
P
A
V
E
A
F
I
---
E
K
V
-------
S
----
R
R
S
N
F
E
F
G
R
A
R
M
F
-----------------
G
C
V
G
W
A
L
G
-----------------
A
S
I
V
-----------------
G
I
M
F
--
T
-----------------------------------------
I
N
N
Q
F
V
-------------
F
W
L
--
G
S
-
G
C
A
--
L
I
-
L
A
V
-
L
-
L
F
-
F
A
K
T
-----
D
-
A
P
S
-------
S
A
---
T
---
V
A
N
-
A
V
-------
G
---------------
A
------------
N
H
----
S
-----------------------------------------------
A
---
F
S
-----------------------------------------------------
L
K
L
A
-
L
---
E
L
------
F
R
Q
P
K
L
W
----------------------
F
L
-----
S
L
----
Y
-
V
I
G
V
S
--
C
-----
T
Y
-----
D
V
F
D
Q
Q
F
A
N
------------
F
F
T
S
F
-
F
AT
G
E
Q
G
----
T
----
R
V
----------
F
G
---
Y
V
T
T
M
G
E
L
-----------------
L
N
A
S
I
M
---
F
F
A
---
P
L
I
I
N
R
I
-----
G
G
K
N
A
------
L
L
L
--
A
G
T
---
I
M
S
V
R
I
I
G
S
-
S
-------
F
-
A
-----------
T
-----
S
A
---
L
----
E
V
V
I
----
L
K
T
L
H
M
--------
F
E
--------
V
P
-
F
-
L
L
V
-------
G
C
F
K
Y
I
T
S
Q
F
-----------------
E
-
V
R
-
F
S
A
T
I
Y
L
V
C
F
------
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
-
G
N
M
Y
E
S
----
I
G
-
F
Q
G
A
---------
Y
L
V
L
G
L
V
A
L
G
F
T
L
---------------------------------------------------------------------------------------
1
PsiBlast_PDB
56.85
21%
-171
- C4 -
1PW4
-
GLPT_ECOLI
A:
[82-412]
------------------------------------------------------------------------------------------------------------------------------------------------
I
M
G
S
V
S
------------
D
R
S
N
-
P
--
R
V
F
-
L
P
A
G
---
L
I
L
A
A
A
----------
V
M
L
F
----
M
G
----
F
------------------
V
-----
P
----
W
A
T
S
SIAV
M
F
V
------
L
L
---
F
L
C
G
W
F
Q
G
M
G
--------
W
-------
P
-
P
C
G
R
T
M
V
---
H
W
W
-------
S
-
Q
--
K
E
R
G
G
I
V
S
V
W
N
C
A
-----------------
H
N
V
G
G
G
I
P
-----------------
P
L
L
F
-----------------
L
L
G
M
--
A
--------------------------
W
--------------
F
N
D
W
H
A
-------------
A
L
Y
M
P
A
F
-
C
A
I
--
L
V
-
A
L
F
-
A
-
F
A
-
M
M
R
D
-----
T
-
P
Q
S
-------
C
G
---
L
---
P
P
I
-
E
E
-------
Y
---------------
K
-------
N
----
D
------------------------------------------------------------------------------------------------------------------------------------
T
A
K
Q
----------------------
I
F
-----
M
Q
----
Y
-
V
L
P
N
K
L
L
W
-----
Y
I
------
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
PT
Y
L
K
E
V
-
K
---
H
F
A
----
L
----
D
K
----------
S
S
---
W
A
Y
F
L
Y
E
Y
-----------------
A
G
I
P
G
T
---
L
L
C
---
G
W
M
S
D
K
V
FRGN
R
G
A
T
G
V
------
F
F
M
--
T
L
V
---
T
I
A
T
I
V
Y
W
M
N
P
-------
A
-
G
-----------
N
-----
P
----
T
----
V
D
M
I
----
C
M
I
V
I
G
--------
F
L
--------
I
Y
-
G
-
P
V
M
-------
L
I
G
L
H
A
L
E
L
A
-----------------
P
-
K
K
A
A
-
G
T
A
A
G
F
T
G
------
L
F
G
Y
L
G
G
-
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
----
F
G
------------------------------------------------------------------------------------------------------------------
16
HHSearch
56.29
17%
-152
- C4 -
4GC0
4
XYLE_ECOLI
A:
[8-429]
--------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
------
F
G
Y
D
T
A
V
I
S
G
T
V
--
E
S
L
--
N
T
------
V
----
F
VAPQNLS
E
S
--------------
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
------------
N
R
-
F
-
G
--
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
----------
S
G
V
G
----
S
A
----
W
PELGFTSINPDNTVPVYL
A
-----
G
----
Y
--------
V
P
------
E
F
---
V
I
Y
R
I
I
G
G
I
G
-
V
G
L
----
A
-------
S
-
M
L
S
P
M
Y
I
---
A
E
L
-------
A
P
A
--
H
I
R
G
K
L
V
S
F
N
Q
F
A
-----------------
I
I
F
G
Q
L
L
V
-----------------
Y
C
V
N
-----------------
Y
F
I
A
--
R
S
GD
A
S
W
L
N
------------------
T
--------------
D
G
W
R
Y
M
-------------
F
A
S
--
E
C
-
I
P
A
--
L
L
-
F
L
M
-
L
-
L
Y
-
T
V
P
E
-----
S
-
P
R
W
-------
L
M
---
S
R
G-
K
Q
E
-
Q
A
-------
E
---------------
G
I
L
R
K
I
MG
N
T
L
A
T
Q
A
----
V
-----------------------------------------------
Q
---
E
I
-----------------------------------------------------
K
H
S
L
-
D
H
G
R
K
T
------
G
--
G
R
L
L
----------------------
M
F
GVG
V
I
V
I
G
V
M
-
L
S
I
F
Q
Q
F
--
V
-----
G
I
-----
N
V
V
L
Y
Y
A
P
E
------------
V
F
-
K
T
-
L
---
G
A
S
----
T
----
D
I
----------
A
L
---
L
Q
T
I
I
V
G
V
-----------------
I
N
L
T
F
T
---
V
L
A
---
I
M
T
V
D
K
F
-----
G
R
K
P
L
------
Q
I
I
--
G
A
L
---
G
M
A
I
G
M
F
S
L
-
G
-------
T
-
A
F
Y
T
--------
Q
A----
P
G
---
I
----
V
A
L
L
----
S
M
L
F
Y
V
--------
A
A
--------
F
A
M
S
-
W
G
P
-------
V
C
W
V
L
L
S
E
I
F
-----------------
P
-
N
A
-
I
R
G
K
A
L
A
I
A
V
------
A
A
Q
W
L
A
N
-
Y
F
V
S
W
T
F
-
P
M
M
---------------------------------------------------------------------------------------------------------------------------
10
HHSearch
53.53
13%
-163
- C4 -
4ZW9
4
GTR3_HUMAN
A:
[38-460]
----------------------------------------------------
V
A
T
I
G
S
F
Q
------
F
G
Y
N
T
G
V
I
N
A
P
E
--
K
I
I
--
K
E
------
F
----
I
--------
T
K
T
L
T
D
K
GNAPPS
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
------------
N
R
-
F
-
G
--
R
R
N
S
M
L
I
V
---
N
L
L
A
V
T
----------
G
G
C
F
----
M
G
----
L
CKV---------------
A
-----
K
----
S
--------
V
E
------
M
L
---
I
L
G
R
L
V
I
G
L
F
-
C
G
L
----
C
-------
T
-
G
F
V
P
M
Y
I
---
G
E
I
-------
S
P
T
--
A
L
R
G
A
F
G
T
L
N
Q
L
G
-----------------
I
V
V
G
I
L
V
A
-----------------
Q
I
F
G
-----------------
L
E
F
I
LG
S
--------------------------
E
--------------
E
L
W
P
L
L
-------------
L
G
F
--
T
I
-
L
P
A
--
I
L
-
Q
S
A
-
A
-
L
P
-
F
C
P
E
-----
S
-
P
R
F
-------
L
L
INR
K
---
E
E
E
N
A
K
-------
Q
I
L
Q
R
L
W
GTQDV
S
Q
D
I
Q
E
M
-----
K
----
D
E
S
A
R
M
S
-----------------------------------------------
Q
---
E
K
-----------------------------------------------------
Q
V
T
V
-
L
---
E
L
------
F
R
V
S
S
Y
R
----------------------
Q
P
-----
I
I
----
I
-
S
I
V
L
Q
--
L
S
Q
Q
L
S
G
I
-----
N
A
V
F
Y
Y
S
T
G
------------
I
F
K
-
D
-
A
-----
G
----
V
----
Q
E
----------
P
I
---
Y
A
T
I
G
A
G
V
-----------------
V
N
T
I
F
T
---
V
V
S
---
L
F
L
V
E
R
A
-----
G
R
R
T
L
------
H
M
I
--
G
L
G
---
G
M
A
F
C
S
T
L
M
-
T
-------
V
-
S
L
L
L
KDNY----
N
G
M
---
S
F
---
V
----
C
I
G
A
----
I
L
V
F
V
A
--------
F
F
--------
E
I
-
G
-
P
G
P
-------
I
P
W
F
I
V
A
E
L
F
-----------------
S
-
Q
G
-
P
R
P
A
A
M
A
V
A
G
------
C
S
N
W
T
S
N
-
F
L
V
G
L
L
F
-
P
S
A
A
H
Y
----
L
G
-
A
Y
V
F
---------
I
I
F
T
G
F
----------------------------------------------------------------------------------------------
29
Fugue
52.45
11%
-177
- C4 -
1PV6
-
LACY_ECOLI
A:
[1-417]
-----------------------
M
Y
Y
L
K
N
------------------
T
N
F
W
M
F
G
L
F
F
F
F
Y
------
F
F
I
M
G
A
Y
F
P
F
F
P
--
I
W
L
--
H
D
------
I
----
N
--------
H
--------------
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
------------
D
K
-
L
-
G
--
L
R
K
Y
L
L
W
I
---
I
T
G
M
L
V
----------
M
F
A
P
----
F
F
----
I
------------------
F
-----
I
----
F
--------
G
P
------
L
L
---
Q
Y
N
I
L
V
G
S
I
V
-
G
G
I
----
Y
LGFCF
N
A
G
-
A
P
A
V
E
A
F
---
I
E
K
-------
V
-
S
--
R
R
S
N
F
E
F
G
R
A
R
M
F
-----------------
G
C
V
G
W
A
L
G
-----------------
A
S
I
V
-----------------
G
I
M
F
--
T
--------------------------
I
--------------
N
N
Q
F
V
F
-------------
W
L
G
--
S
G
-
C
A
L
--
I
L
-
A
V
L
-
L
-
F
F
-
A
K
T
D
-----
A
-
P
S
S
-------
A
T
---
V
---
A
N
A
-
V
G
-------
A
---------------
N
-------
H
----
S
A
----
F
-----------------------------------------------
S
---
L
K
-----------------------------------------------------
L
A
L
E
-
L
---
F
R
------
Q
--
P
K
L
W
----------------------
F
L
-----
S
L
----
Y
-
V
I
G
V
S
--
C
-----
T
Y
-----
D
V
F
D
Q
Q
F
A
N
------------
F
F
T
S
F
-
F
---
A
T
G
----
E
----
Q
G
----------
T
R
---
V
F
G
Y
V
T
T
M
-----------------
G
E
L
L
N
A
---
S
I
M
F
F
A
P
L
I
I
N
R
I
-----
G
G
K
N
A
------
L
L
L
--
A
G
T
---
I
M
S
V
R
I
I
G
S
-
S
-------
F
-
A
-----------
T
S
A
L
--
E
----
V
----
V
I
L
K
----
T
L
H
M
F
E
--------
V
P
--------
F
L
-
L
-
V
G
C
-------
F
K
Y
I
T
S
Q
F
E
V
-----------------
R
-
F
S
-
A
-
T
I
Y
L
V
C
F
C
------
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
-
G
N
M
Y
E
S
----
I
G
-
F
Q
G
A
---------
Y
L
V
L
G
L
V
A
L
G
F
T
L
-
I
S
V
F
T
LSGPG
P
L
S
L
L
R
R
Q
V
N
E
V
A---------------------------------------------------------------
17
HHSearch
51.83
12%
-180
- C4 -
4ZP0
3
MDFA_ECOLI
A:
[12-369]
---------------------------------------------------
L
C
L
V
L
Y
E
F
S
------
T
Y
I
G
N
D
M
I
Q
P
G
M
--
L
A
V
--
V
E
------
Q
----
Y
--------
Q
--------------
A
G
I
D
W
V
P
T
S
M
T
A
Y
L
A
G
G
M
F
L
Q
W
L
L
G
P
L
S
------------
D
R
-
I
-
G
--
R
R
P
V
M
L
A
G
---
V
V
W
F
I
V
----------
T
C
L
A
----
I
L
----
L
------------------
A
-----
Q
----
N
--------
I
E
------
Q
F
---
T
L
L
R
F
L
Q
G
I
S
-
L
C
F
----
I
-------
G
-
A
V
G
Y
A
A
I
---
R
E
S
-------
F
E
E
--
A
V
C
I
K
I
T
A
L
M
A
N
V
-----------------
A
L
I
A
P
L
L
G
-----------------
P
L
V
G
-----------------
A
A
W
I
--
H
--------------------------
V
--------------
L
P
W
E
G
M
-------------
F
V
L
--
F
A
-
A
L
A
--
A
I
S
F
F
G
-
L
-
Q
R
-
A
M
P
E
-----
T
-
A
T
R
-------
I
G
---
E
---
K
---
L
--------------------------------------
S
----
L
-----------------------------------------------
K
---
E
L
-----------------------------------------------------
G
R
D
Y
-
K
---
L
V
------
L
K
N
G
R
F
V
----------------------
A
G
-----
A
L
----
A
-
L
G
F
V
S
--
L
-----
P
L
-----
L
A
W
I
A
Q
S
P
I
------------
I
I
I
T
G
-
E
---
Q
L
S
----
S
----
Y
E
----------
Y
G
---
L
L
Q
V
P
I
F
G
-----------------
A
L
I
A
G
N
---
L
L
L
---
A
R
L
T
S
R
R
-----
T
V
R
S
L
------
I
I
M
--
G
G
W
---
P
I
M
I
G
L
L
V
A
-
A
A
A
T
V
I
--
S
-
S
-----------
H
-----
A
Y
---
L
----
W
M
T
A
----
G
L
S
I
Y
A
--------
F
G
--------
I
G
-
L
-
A
N
A
-------
G
L
V
R
-
L
T
L
F
A
-----------------
S
-
D
M
-
S
K
G
T
V
S
A
A
M
G
------
M
L
Q
M
L
I
F
-
T
V
G
I
E
I
S
-
K
H
A
W
L
N
----
G
G
-
N
----------------------------------------------------------------------------------------------------------------
33
Fugue
50.53
18%
-148
- C2 -
4Q86
4
YCAO_ECOLI
A:
[2-583]
T
Q
T
F
I
P
GKDAA
L
E
D
S
I
A
R
F
Q
Q
K
L
S
D
L
G
F
Q
I
E
E
-
A
S
W
L
N
P
----
V
P
N
V
W
S
V
H
I
R
D
K
E
C
A
L
C
F
T
N
G
K
G
A
T
K
K
A
A
L
A
S
A
L
G
--
E
Y
F
--
E
R
------
L
----
S
--------
T
--------------
N
Y
F
F
A
D
F
W
L
G
E
T
I
A
N
G
P
F
V
H
Y
P
N
E
K
W
F
P
L
TENDDVPEGLL
D
D
-
R
-
L
--
R
A
F
Y
D
P
E
N
E--
L
T
G
S
M
L
IDLQSGNEDR
G
I
C
G
----
L
P
----
F
------------------
T
RQSD-
N
----
Q
--------
T
V
------
Y
I
P
M
N
I
I
G
N
L
Y
V
S
N
G
-
M
S
A
----
G
-------
N
T
R
N
E
A
R
V
Q
---
G
L
S
-------
E
-
V
--
F
E
R
Y
V
K
N
R
I
I
A
E
S
I
S
L
P
E
IP
A
D
V
L
A
R
Y
P
A
V
V
E
A
I
E
T
L
E
A
E
G
F
P
I
F
A
Y
D
GSLGGQY
P
V
I
C
-----------------
V
V
L
F
--
N
--------------------------
P
----------------
A
N
G
T
-------------
C
F
A
--
S
F
-
G
A
H
PD
F
G
-
V
A
L
-
E
-
R
T
-
V
T
E
L
-----
L
-
Q
G
R
GLKD---
L
D
---
V
---
F
T
P
-
P
T
-------
F
---------------
D
-------
D
----
E
E
----
V
-----------------------------------------------
A
---
E
H
-----------------------------------------------------
T
N
L
E
-
T
---
H
F
------
I
--
D
S
S
G
----------------------
L
I
-----
S
W
----
D
-
L
F
K
Q
D
----------------------
A
D
------------
Y
P
F
V
D
-
W
---
N
F
S
----
G
----
T
T
----------
E
E
---
E
F
A
T
L
M
A
I
-----------------
F
N
K
E
D
K
E
V
Y
I
A
D
---
Y
E
H
L
G
V
Y
-----
A
C
R
I
I
------
V
P
G
MS
D
I
Y
---
P
A
E
D
L
W
L
A
N
-
N
-------
S
-
M
-----------
G
-----
S
----
H
----
L
R
E
T
----
I
L
S
L
P
G
SEWE
K
E
D
Y
L
N
--------
L
I
-
E
-
Q
L
D
E
E
GFDDF
T
R
V
R
E
L
L
G
L
A
-----------------
T
-
G
S
-
D
-
N
G
W
Y
T
L
R
I
------
G
E
L
K
A
M
L
-
A
L
A
G
G
D
L
-
E
Q
A
L
V
W
----
T
E
-
W
T
M
E
---------
F
N
S
S
V
F
S
P
E
R
A
N
Y
-
Y
R
C
L
------
Q
T
L
L
L
L
A
Q
E
E
D
RQPLQY
L
N
A
F
V
R
M
YG
A
D
A
V
E
A
A
S
A
A
M
S
GEAAFYGLQPVDSDLHAF
A
A
H
Q
S
L
L
K
A
Y
E
K
L
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R
A
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A
A
F