@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu07570: (2016-06-12 )
MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHLFAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFISRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPIIRSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGVDLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSELSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTWFAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHISAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWWSIGFILSIVHIIVWLVIGGLWWKVLGIW
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------.........10......--------..20........----------30......-----..40...------.....50.---------------------......--------.60........70..-----.--.....80.....-------------------------...90........100....-----------...110.......120.......130..--------.....140.......150.......160----------........170.......180....-...190......-.200.......210...--...-----.-220--------.-----.......230......-------------.240----........--250.......260.----......270....-...---280...--------....290---.-------..-----------.--.-------..300---------.........310--...---.----..-.----.320.......------330-----........340.......350.-......360....---.--...370.......380------....--..---------...390......-.400----........410----..------......420.......430--.---.....---...440.----..-----....450.......460.......470......------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------MASEKDAG
K
Q
S
A
V
K
L
V
P
--------
L
L
I
T
V
A
V
G
L
I
I
W
----------
F
IPAPSGL-----EP
K
A
W
H
L
------
F
A
I
F
V
A
T
I
---------------------
I
G
F
ISK--------PLP
M
G
A
I
A
I
F
A
L
A
V
T
-----
A
--LTG
T
L
S
I
E
D
T
L
S-------------------------GFGN
K
T
I
W
L
I
V
I
A
F
F
I
S
R
G
F
-----------
I
KTGLG
A
R
I
S
Y
V
F
V
Q
K
FG
K
K
TLG
L
S
Y
S
L
--------
L
F
S
D
L
ILSPAIPSNTARAG
G
I
I
F
P
I
I
R
-----------
S
L
S
E
T
FGSSPANG
T
E
R
K
I
G
A
F
L
L
KT-GFQG
N
L
I
T
S
A
M
F
-
L
T
A
MAA
N
P
L
I
A
K
L
A
H
D
V--AGV-----
D
-
L
T---------
W
-----
T
S
W
A
I
A
A
I
V
P
G
L
V
S
L
I
-------------
I
T
P
-----
L
V
I
YKLYP--PEIKETP
D
A
A
K
I
A
T
----
E
K
L
K
E
MGPF
K
K
S
E
-
L
S
M
---
V
I
V
F
L
L
--------
V
L
V
L
W
I
F---G-------GS-----------F--N-------I
D
A
-----------
T
T
T
A
L
I
G
L
A
V
L
---
L
L
S
---
Q
----VL-
T
----
W
D
D
I
K
K
EQGA
W
------
D
T
------
L
T
W
F
A
A
L
V
M
L
A
N
F
L
N
E
L
G
M
V
S
W
-
F
S
N
A
M
K
S
S-VS
G
F
---
S
--
W
I
V
A
F
I
I
L
I
V
V
Y
Y
Y
--------
S
H
Y
F
--FA---------
S
A
T
A
H
I
S
A
M
Y
S
A
-
F
L
A
-----
V
V
V
AAGA
P
P
L
-----
L
A
------
A
L
S
L
A
F
I
S
N
L
FGSTTHY----G---SGAA
P
---
V
F
F
GAGY----IP-----QGKW
W
S
I
G
F
I
L
S
I
V
H
I
I
V
W
L
V
I
G
G
L
W
W
K
V
LGIW------------------------------------
21
HHSearch
88.31
21%
-194
- C4 -
4F35
2
?
D:
[28-449]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-----
E
H
N
V
V
L
G
------
I
S
M
L
A
F
I
A
---------------------
V
L
W
L
T
E
--------
A
L
H
V
T
V
T
A
I
L
V
P
V
M
A
-----
V
--
F
F
G
I
F
E
T
Q
A
A
L
N
-------------------------
N
F
A
N
S
I
I
F
L
F
L
G
G
F
A
L
A
A
A
M
-----------
H
H
Q
G
L
D
K
V
I
A
D
K
V
L
A
M
A
Q
G
K
M
S
V
A
V
F
M
L
--------
F
G
V
T
A
L
L
S
M
W
I
-
S
N
T
A
T
A
-
A
M
M
L
P
L
V
L
-----------
G
V
L
S
K
V
D
A
D
K
Q
R
----
S
T
Y
V
F
V
L
L
G
-
V
A
Y
S
A
S
I
G
G
I
A
T
-
L
V
G
S
P
P
N
A
I
A
A
A
E
V
-------------
G
-
L
S
---------
F
-----
T
D
W
M
K
F
G
L
P
T
A
M
M
M
L
P
-------------
M
A
I
-----
A
I
L
Y
F
L
L
---------------------------
V
N
W
D
K
G
K
-
V
V
T
---
L
G
I
F
G
L
--------
T
V
F
L
W
I
F
---
S
-------
S
P
-----------
I
--
N
A
A
LGGFK
S
F
D
-----------
T
L
V
A
L
G
A
I
L
M
L
---
S
F
A
---
R
----
V
V
-
H
----
W
K
E
I
-
Q
K
T
A
D
W
------
G
V
------
L
L
L
F
G
G
G
L
C
L
S
N
V
L
K
Q
T
G
T
S
V
F
-
L
A
N
A
L
S
D
M
-
V
S
H
M
---
G
--
I
F
V
V
I
L
V
V
A
T
F
V
V
F
--------
L
T
-
E
--
F
A
---------
S
N
T
A
S
A
A
L
L
I
P
V
-
F
A
T
-----
V
A
E
A
F
G
M
S
P
V
-----
L
L
------
S
V
L
I
A
V
A
A
-
S
C
A
F
M
L
P
V
----
A
---
T
P
P
N
A
---
I
V
F
A
S
G
H
----
I
K
-----
Q
S
E
M
M
R
V
G
L
Y
L
N
I
A
C
I
G
L
L
T
A
I
A
M
L
F
W
Q
-----------------------------------------
30
Fugue
64.82
18%
-168
- C4 -
5A1S
10
?
A:
[16-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
L
R
F
K
I
F
----------
G
M
P
----
L
-----
P
L
Y
A
F
A
L
------
I
T
L
L
L
S
H
F
---------------------
Y
N
A
I
P
T
--------
D
L
V
G
G
F
A
L
M
F
V
M
G
A
I
-----
F
G
E
I
G
K
R
L
P
I
F
N
K
Y
I
-------------------------
G
-
G
A
P
V
M
I
F
L
V
A
A
Y
F
V
Y
A
G
I
-----------
F
T
Q
K
E
I
D
A
I
S
N
V
M
D
K
S
---
N
F
L
N
L
F
I
A
V
--------
L
I
T
G
A
I
L
S
V
N
R
K
L
L
L
K
S
L
L
G
Y
I
P
T
I
L
A
-----------
G
I
V
G
A
S
L
F
G
I
V
I
G
L
C
F
G
I
P
V
D
R
I
M
M
-
L
Y
V
L
P
I
M
G
G
G
----
N
G
A
G
A
V
P
L
-
S
E
I
Y
H
S
V
--
T
G
R
S----
R
-
E
E
---------
Y
-----
Y
S
T
A
I
A
I
L
T
I
A
N
I
F
A
I
-------------
I
F
A
-----
A
L
L
D
M
V
G
K
--
K
Y
T
W
L
S
G
E
G
E
L
V
R
K
----
A
S
F
K
T
E
D
D
E
K
A
G
Q
-
I
T
----------------------------------------------------
H
-------
R
E
T
-----------
A
V
G
M
V
L
S
T
T
C
F
---
L
L
A
---
Y
----
V
V
-
A
----
K
K
I
L
P
S
I
G
G
V
--------
S
------
I
H
Y
F
A
W
M
V
L
I
V
A
A
L
N
A
S
G
L
C
S
P
-
E
I
K
A
G
A
K
R
-
L
S
D
F
F
S
K
Q
--
L
L
W
V
L
M
V
G
V
G
V
C
Y
T
--------
D
L
Q
E
--
I
I
---------
D
A
L
T
F
A
N
V
V
I
A
A
-
I
I
V
-----
V
G
A
V
V
G
A
A
I
G
-----
G
W
------
L
I
G
F
Y
P
I
E
S
S
I
T
A
G
L
C
M
ANRG
G
---
S
G
D
L
E
---
V
L
S
A
C
N
------------
R
M
N
L
I
S
Y
A
Q
I
S
S
R
L
G
G
G
I
V
L
V
I
A
S
I
V
F
S
M
M
V
L
E
------------------------------------
31
Fugue
63.43
16%
-114
- C4 -
3WOL
10
DAPB2_PSEMX
A:
[1-696]
GEGMWVPQQLPEI
A
G
P
L
K
K
A
GLKLS
P
Q
Q
I
S
DLTGDPMGAVVALGG
C
T
A
S
F
VSPNG
L
V
V
T
N
HHCA
Y
G
A
I
Q
L
N
STAENNLIK
N
G
F
N
A
PTTADEVSAGPN
A
R
V
F
V
L
D
E
ITDV
T
K
D
A
K
A
A
I
A
A
A
GDD
A
L
A
R
T
K
A
L
E
A
F
E
K
K
L
I
A
D
C
E
A
E
A
G
F
R
C
R
L
Y
S
F
SGGN
T
Y
R
L
F
K
N
L
E
I
K
D
V
R
L
----------
A
Y
A
P
P
G
S
V
G
K
FGG
D
I
D
N
W
M
W
PRHTGD
F
A
F
Y
R
A
Y
V
G
KDG
K
P
A
A
F
SKDN
V
P
Y
Q
P
K
H
W
L
K
F
A
D
Q
--------
P
L
G
A
G
D
F
V
M
V
A
G
Y
P
G
S
TNRY
A
--
L
A
A
E
F
D
N
T
A
Q
W
T
-------------------------
Y
P
T
I
A
R
H
Y
K
N
Q
I
A
M
V
E
A
A
G
K
Q
N
A
D
I
Q
V
K
Y
A
A
T
M
A
G
W
N
N
T
S
K
N
Y
D
G
Q
L
E
G
F
K
R
I
D
A
A
G
Q
K
--------
L
R
E
E
A
A
V
L
G
W
L
K
G
Q
G
A
K
G
Q
P
A
L
D
A
H
A
K
-----------
L
L
D
L
L
E
Q
S
K
A
T
R
D
R
D
L
T
L
A
L
F
N
-----------
N
T
A
M
L
-
G
S
A
T
Q
L
Y
R
L
S
I
E
R
E
K
P
N
--
A
E
R
-----
E
-
S
G
---------
Y
-----
Q
E
R
D
L
P
A
I
E
G
G
L
K
Q
L
E
-------------
R
R
Y
V
A
A
M
D
R
Q
L
Q
E
Y
W
L
--
N
E
Y
I
K
L
P
A
D
Q
R
V
A
A
----
V
D
-
A
W
L
G
G
N
D
A
A
A
-
V
K
R
---
A
L
D
R
L
A
G
TKLGS
T
E
E
R
L
K
W
F
A
---
A
-------
D
R
-----------
K
--
A
-------
F
E
A
-----------
S
N
D
P
A
I
Q
Y
A
V
A
---
V
M
P
---
T
----
L
L
-
K
----
L
E
Q
E
R
K
T
R
A
G
E
------
N
L
------
A
A
R
P
V
Y
L
Q
A
L
A
D
Y
K
K
S
Q
G
----------------
E
F
---
V
--
Y
P
D
A
N
L
S
L
R
I
T
F
G
N
--------
V
M
G
Y
--
A
P
---------
K
D
G
M
E
Y
T
P
F
T
T
L
-
E
G
V
-----
V
A
K
E
T
G
Q
D
P
F
DS---
P
K
------
A
L
L
D
A
V
A
A
K
R
Y
G
G
L
E
D
K
----
R
---
I
G
S
V
P
---
V
N
Y
L
S
D
L
D
---
I
T
-----
G
G
N
--
S
G
S
P
V
L
D
A
H
G
K
L
V
G
L
A
F
D
G
N
W
E
S
V
S
S
N
W
VFDPKM
T
R
M
I
A
V
D
G
R
Y
L
R
W
I
M
Q
EVYPA
P
Q
L
L
K
E
M
NV
22
HHSearch
61.04
17%
-160
* C4 *
4R1I
-
?
A:
[97-510]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
L
V
S
L
L
G
V
G
I
A
-----------
E
K
S
G
L
I
S
A
L
M
R
L
L
L
T
K
S
P
R
K
---
L
T
T
F
M
--------
V
V
F
T
G
I
L
S
N
T
A
-
S
E
-
L
G
Y
-
V
V
L
I
P
L
S
A
-----------
V
I
F
H
S
L
G
R
H
P
L
---------
A
G
L
A
A
-
A
F
A
G
V
-
S
G
G
Y
S
A
N
L
F
L
G
T
I
D
P
L
L
A
G
I
T
Q
Q
A
--
A
Q
I
-----
I
H
P
D
---------
Y
V
V
G
PE
A
N
W
F
F
M
A
-
A
S
T
F
V
I
A
L
-------------
I
G
Y
-----
F
V
T
E
K
I
V
E
--
P
Q
L
G
-
P
Y
Q
S
D
L
S
Q
E
E
K
D
I
R
H
S
N
E
I
T
P
L
E
Y
K
G
L
I
W
A
---
G
V
V
F
I
A
--------
L
S
A
L
L
A
W
S
I
V
P
-------
A
D
-----------
G
IL
R
-------
H
P
E
TGLVAGSPFLK
S
I
V
V
F
I
F
L
L
F
A
L
P
G
I
V
Y
G
R
I
T
RS--
L
R
-
G
----
E
R
E
-
V
V
N
A
M
A
E
------
S
M
S
T
L
G
L
Y
L
V
I
I
F
F
A
A
Q
F
V
A
F
F
N
W
T
N
I
G
Q
Y
-
I
A
V
K
G
A
V
F
-
L
K
E
V
---
G
LA
G
S
V
L
F
I
G
F
I
L
I
C
A
F
--------
I
N
L
M
--
I
G
---------
S
A
S
A
Q
W
A
V
T
A
P
I
-
F
V
P
-----
M
L
M
L
A
G
Y
A
P
E
-----
V
I
------
Q
A
A
Y
R
I
G
D
S
V
T
N
I
I
T
P
M
----
M
---
S
Y
F
G
L
---
I
M
A
T
V
M
K
Y
KKD
A
G
-----
V
G
T
L
I
S
M
M
L
P
Y
S
A
F
F
L
I
A
W
I
A
L
F
C
I
W
V
F
V
L
G
L
P
------------------------------------
1
PsiBlast_PDB
60.64
26%
-241
- C4 -
4F35
-
?
D:
[245-449]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
G
K
-
V
V
T
---
L
G
I
F
G
L
--------
T
V
F
L
W
I
F
---
S
S
P
I
N
A
A
L
G
G
-----------
F
--
K
-------
S
F
D
-----------
T
L
V
A
L
G
A
I
L
M
L
---
S
F
A
---
R
----
V
V
-
H
----
W
K
E
I
Q
K
T
A
D
-
W
------
G
V
------
L
L
L
F
G
G
G
L
C
L
S
N
V
L
K
Q
T
G
T
S
V
F
-
L
A
N
A
L
S
D
M
-
V
S
H
M
---
G
-----
I
F
V
V
I
L
V
V
A
T
F
--------
V
V
F
L
TE
F
A
---------
S
N
T
A
S
A
A
L
L
I
P
V
-
F
A
T
-----
V
A
E
A
F
G
M
S
P
V
-----
L
L
------
S
V
L
I
A
----
V
A
A
S
C
A
F
M
----
L
---
P
V
A
T
P
P
N
A
I
V
F
A
S
G
H
----
I
K
-----
Q
S
E
M
M
R
V
G
L
Y
L
N
I
A
C
I
G
L
L
T
A
I
A
M
L
F
W
Q
-----------------------------------------
23
HHSearch
58.29
12%
-156
- C4 -
4R0C
6
?
A:
[85-489]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
V
A
M
L
G
L
G
V
A
-----------
E
Q
S
G
L
L
S
V
S
L
A
S
L
V
R
R
S
S
G
G
A
L
---
V
F
T
--------
V
A
F
A
G
V
L
S
S
L
T
-
V
D
A
G
Y
V
--
V
L
I
P
L
A
G
-----------
L
V
F
Q
L
A
G
R
P
P
I
A
---------
G
I
A
T
-
A
F
A
A
V
S
G
G
F
S
A
N
-
L
L
V
G
P
V
D
A
T
L
A
G
L
S
T
E
A
--
A
H
I
IDPD
R
T
-
V
A
---------
A
-----
T
G
N
Y
W
F
I
I
A
S
T
F
L
V
T
G
-------------
L
V
T
-----
L
I
T
R
--
T
L
--
T
E
P
R
L
-
A
H
A
N
T
V
A
D
----
A
S
V
D
A
P
Q
I
H
S
R
A
M
-
K
W
T
G
L
T
L
A
I
L
L
A
--------
G
L
A
L
L
V
L
---
P
-------
N
D
APLRHPDTGSV
L
--
G
-------
S
P
F
I
----------
H
G
L
V
V
I
V
A
L
I
A
---
G
I
C
---
G
A
V
Y
G
R
V
S
G
QFRN
S
G
A
V
-
I
T
A
M
E
V
T
M
A
S
M
A
G
Y
------
L
V
L
M
F
F
A
A
Q
F
V
A
W
F
N
Y
S
Q
L
G
L
L
L
A
V
K
G
A
A
W
L
G
A
L
T
V
---
P
--
K
V
V
L
L
L
L
F
V
V
L
T
A
L
--------
I
N
L
M
--
I
G
---------
S
A
S
A
K
W
S
I
L
A
P
V
-
F
I
P
-----
M
L
M
L
L
G
I
S
P
E
-----
A
S
------
Q
A
A
Y
R
V
G
D
S
S
T
N
I
I
T
P
L
----
M
---
P
Y
-
F
V
---
L
V
L
G
F
A
R
----
R
Y
QPETG
I
G
T
L
I
A
L
M
L
P
Y
S
L
T
L
L
L
G
W
S
-
V
L
L
G
V
W
I
G
F
G
W
P
------------------------------------
29
Fugue
50.32
10%
-158
- C4 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-----------------------------------------------------------------------------------------------------------------------------------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
-----------------------------------
I
D
P
T
Y
R
-----
R
L
R
W
Q
I
F
------
L
G
I
F
F
G
Y
A
---------------------
A
Y
Y
L
V
R
--------
K
N
-------
F
A
L
A
M
P
-----
Y
--
L
V
E
Q
---------------------------------
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
-----------
S
K
F
I
M
G
S
V
S
D
R
-----
S
N
P
R
V
F
L
P
A
G
L
I
--------
L
A
A
A
V
M
L
F
M
G
F
V
P
W
A
T
S
S
I
A
V
M
F
V
L
L
F
-----------
L
C
G
W
F
Q
G
M
G
------
W
P
P
C
G
R
T
M
V
H
-
W
W
S
Q
K
E
R
G
G
I
V
S
-
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
--
L
L
G
-----
M
-
A
W
---------
F
-----
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
-------------
V
A
L
-----
F
A
F
A
M
M
-------
R
D
T
P
Q
S
C
G
L
P
P
----
I
E
E
Y
K
N
D
T
A
K
Q
I
F
-
M
Q
Y
---
V
L
P
N
----------
K
L
L
W
Y
I
A
---
I
-------
A
N
-----------
V
--
F
-------
V
Y
L
-----------
L
R
Y
G
I
L
D
W
S
P
T
---
Y
L
K
---
E
----
V
K
-
H
----
F
A
---
L
D
K
S
S
W
------
A
Y
------
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
-
R
G
N
R
G
A
T
G
-
V
F
F
M
---
T
--
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
--------
G
N
P
T
--
V
D
---------
M
I
C
M
I
V
I
G
F
L
I
Y
-
G
P
V
-----
M
L
I
G
L
H
A
L
E
L
-----
A
P
------
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
----
G
---
G
S
V
A
A
---
S
A
I
V
G
Y
T
----
V
D
-----
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
LLQELVP---------------------------
36
Fugue
46.04
14%
-126
- C2 -
3BMX
7
NAGZ_BACSU
A:
[26-642]
----------------------------------------------------------------------------------------------------A
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
MS
L
D
E
K
L
G
Q
M
L
M
P
D
FR
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
--------
L
V
K
K
Y
Q
F
G
G
I
I
L
F
AENVKT
T
K
Q
T
V
Q
L
T
D
D
Y
-----
Q
K
A
S
P
K
I
------
P
L
M
L
S
I
D
Q
---------------------
E
G
G
I
V
T
RLGEGTNF
P
G
N
M
A
L
G
A
A
R
S
R
I
N
A
-----
Y
--
Q
T
G
S
I
I
G
K
E
L
S
A
L
GINTDFSPVVDINNNPDNPVIGVR
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
-----------
Q
R
Q
D
I
A
S
A
L
K
H
F
P
--
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
SHG
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
A
D
M
V
M
T
A
H
V
Q
FPAFDD
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
F
N
G
V
I
V
T
D
A
L
N
-
M
K
A
I
A
D
H
F
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
-----
D
-
I
A
LMPASVTSL
K
-----
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
GDIP
E
Q
Q
I
N
N
S
V
E
R
-----
I
I
S
L
K
I
K
R
GM
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
----
K
A
K
K
I
V
G
S
K
Q
H
L
K
-
A
E
K
---
K
L
A
E
K
A
--------
V
T
V
L
K
N
E
---
Q
-------
H
T
-----------
L
--
P
-------
F
K
P
-----------
K
K
G
S
R
I
L
I
V
A
P
---
Y
E
E
---
Q
----
T
A
-
S
----
I
E
Q
T
I
H
D
L
I
K
R
------
K
K
------
I
K
P
V
S
L
S
K
M
N
F
A
S
Q
V
F
K
--------
T
E
H
E
K
Q
-
V
K
E
A
---
D
--
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
--------
V
N
D
G
--
V
I
DDTISDSSK
W
A
T
V
F
P
R
A
V
M
K
A
-
A
L
Q
H
NKP
F
V
L
M
S
L
R
N
P
Y
D
-----
A
A
NFEEAK
A
L
I
A
V
Y
G
F
K
G
Y
A
N
G
R
Y
L
----
Q
P
N
I
P
A
G
V
M
---
A
I
F
G
Q
-
A
----
K
P
-----
K
G
T
L
P
V
D
I
P
S
V
T
K
P
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------
24
HHSearch
37.45
16%
0
- C- -
4F35
2
?
D:
[31-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
-
V
L
G
---
I
S
M
L
A
F
--------
I
A
V
L
W
L
T
---
E
-------
A
-----------------------
L
H
V
-----------
T
V
T
A
I
L
V
P
V
M
A
---
V
F
F
---
G
----
I
F
-
E
----
T
Q
A
A
-
L
N
N
F
A
N
------
S
I
------
I
F
L
F
L
G
G
F
A
L
A
A
A
M
H
H
Q
G
L
D
K
V
-
I
A
D
K
V
L
A
M
-
A
Q
G
K
---
M
--
S
V
A
V
F
M
L
F
G
V
T
A
L
L
--------
S
M
----
W
I
---------
S
N
T
A
T
A
A
M
M
L
P
L
-
V
L
G
-----
V
L
S
K
V
D
A
D
K
Q
RSTYV
F
V
------
L
L
G
V
A
Y
S
A
S
I
G
G
I
A
T
L
V
----
G
---
S
P
P
N
A
---
I
A
A
A
E
V
G
----
L
S
-----
F
T
D
W
M
K
F
G
L
P
T
A
M
M
M
L
P
M
A
I
A
I
L
Y
F
L
L
------------------------------------------
16
PsiBlast_PDB
36.52
26%
-197
- C5 -
3SJ6
2
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
11
PsiBlast_PDB
36.37
26%
-198
- C5 -
3NX9
2
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
14
PsiBlast_PDB
36.09
26%
-195
- C5 -
3RL9
2
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
13
PsiBlast_PDB
35.89
26%
-193
- C5 -
3QJI
1
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
8
PsiBlast_PDB
35.81
26%
-198
- C5 -
3N1N
1
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
19
PsiBlast_PDB
35.73
26%
-196
- C5 -
3U6Z
2
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
18
PsiBlast_PDB
35.52
26%
-193
- C5 -
3U8F
2
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
12
PsiBlast_PDB
35.18
26%
-194
- C5 -
3Q4P
2
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
17
PsiBlast_PDB
35.14
26%
-196
- C5 -
3U6T
2
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
20
PsiBlast_PDB
34.71
26%
-195
- C5 -
3U70
2
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------
15
PsiBlast_PDB
34.67
26%
-194
- C5 -
3S9Q
1
?
A:
[70-147]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
M
G
Y
L
A
L
T
T
S
Y
F
F
NE
P
A
A
D
L
A
S
Q
Y
V
--
F
R
---------
S
A
R
R
K
I
T
L
P
Y
S
G
N
Y
E
R
-----
L
Q
I
A
A
G
K
P
R
E
-----
K
I
------
P
I
G
L
P
A
L
D
T
A
I
S
T
L
L
H
Y
----
D
---
S
T
A
A
-------------------------------------------------------------------------------------------