@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08440: (2016-06-13 )
MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAMGTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVGLETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANAVNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQLGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQWTSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK
Atome Classification :
(20 SA)
.........10........20........30...-......40...-------.-...-.50........60.-.......70..--......80....--...-.---90..---------.--.-....100.......110.......120-.......130.......140-----...-----....150--.........160---..--.--.....170.......----180......----.-190.......200.......-------.210.----......220.......230-.......240.......250......----.260..-..--...---270.....-.-----.280-..-.....290-....-...300.-.-.--.....310.......320...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
H
I
S
M
L
F
V
F
L
M
A
V
M
V
L
S
ACNSSESSSNS-EVS-SSK
T
R
T
V
K
HAM-------G-TSD-NIPANP
K
R
I
V
V
L
TN-EG
T
E
A
L
L
A
LGI--KPVGAVKSWKGD--
P
W
Y
-
D
---
Y
L
K
D
---------
D
--
M
-
K
G
V
K
NVGLETEP
N
V
E
A
I
A
ELKPD
L
I
IG-
N
K
V
R
Q
E
K
I
Y
D
Q
L
N
A
I
A
P
T
V
F
-----
A
E
S
-----
L
AGNW----KD
N
L
T
L
Y
A
NAV----NK--A--DK
G
K
E
V
I
A
D
F
D
K
R
V
S
----
D
L
K
N
K
LGDQ----T-N
K
T
V
S
V
V
R
FLS-GE
S
R
I
Y
YT-------DSF
P
G
----
I
I
L
D
Q
LGFKR
P
E
K
Q
V
E
L
F
K
-KQKD
Q
F
T
FSTDSKESIPDMDA
D
V
L
F
Y
----
F
T
Y
KAD-NA--K
E
N
---
E
K
W
A
N
QW
T
-
S
-----
S
S
L
W
-
K
N
-
L
K
A
VKSGN-AHEV-
D
D
V
V
W
-T-T-A--G
G
I
K
A
A
N
Y
L
L
D
D
I
E
T
Y
FLKTK
34
HHSearch
82.62
59%
-69
- C2 -
3TNY
1
?
A:
[17-296]
-------------------------------------
E
V
V
T
V
E
H
A
M
-------
G
-
K
-
T
-
E
V
P
A
N
P
K
R
V
V
I
L
T
N
-
E
G
T
E
A
L
L
E
L
G
V
--
K
P
V
G
A
V
K
S
W
T
G
D
--
P
W
Y
-
P
---
H
I
K
D
---------
K
--
M
-
K
D
V
K
V
V
G
D
E
G
Q
V
N
V
E
T
I
A
S
L
K
P
D
L
I
I
G
-
N
K
M
R
H
E
K
V
Y
E
Q
L
K
A
I
A
P
T
V
F
-----
S
E
T
-----
L
R
G
E
W
----
K
D
N
F
K
F
Y
A
K
A
L
----
N
K
--
E
--
K
E
G
Q
K
V
V
A
D
Y
E
S
R
M
K
----
D
L
K
G
K
L
G
D
K
----
V
-
N
Q
E
I
S
M
V
R
F
M
P
-
G
D
V
R
I
Y
H
G
-------
D
T
F
S
G
----
V
I
L
K
E
L
G
F
K
R
P
G
D
Q
N
K
-------
D
D
F
A
E
R
N
V
S
K
E
R
I
S
A
M
D
G
D
V
L
F
Y
----
F
T
F
D
K
G
-
N
E
--
K
K
G
---
S
E
L
E
K
E
Y
I
-
N
-----
D
P
L
F
-
K
N
-
L
N
A
V
K
N
G
K
-
A
Y
K
V
-
D
D
V
I
W
-
N
-
T
-
A
--
G
G
V
I
A
A
N
L
L
L
D
D
I
E
K
R
F
V
---
1
PsiBlast_PDB
81.92
56%
-69
- C2 -
3TNY
1
?
A:
[17-296]
-------------------------------------
E
V
V
T
V
E
H
A
M
-------
G
-
K
T
E
--
V
P
A
N
P
K
R
V
V
I
L
T
N
-
E
G
T
E
A
L
L
E
L
G
V
--
K
P
V
G
A
V
K
S
W
T
G
D
--
P
W
Y
-
P
---
H
I
K
D
---------
K
--
M
-
K
D
V
K
V
V
G
D
E
G
Q
V
N
V
E
T
I
A
S
L
K
P
D
L
I
I
G
-
N
K
M
R
H
E
K
V
Y
E
Q
L
K
A
I
A
P
T
V
F
-----
S
E
T
-----
L
R
G
E
W
----
K
D
N
F
K
F
Y
A
K
A
L
----
N
K
--
E
--
K
E
G
Q
K
V
V
A
D
Y
E
S
R
M
K
----
D
L
K
G
K
L
G
D
K
----
V
-
N
Q
E
I
S
M
V
R
F
M
P
-
G
D
V
R
I
Y
H
G
-------
D
T
F
S
G
----
V
I
L
K
E
L
G
F
K
R
P
G
D
Q
-------
N
K
D
D
F
A
E
R
N
V
S
K
E
R
I
S
A
M
D
G
D
V
L
F
Y
----
F
T
F
D
K
G
-
N
E
--
K
K
G
---
S
E
L
E
K
E
Y
I
-
N
-----
D
P
L
F
-
K
N
-
L
N
A
V
K
N
G
K
-
A
Y
K
V
-
D
D
V
I
W
-
N
-
T
-
A
--
G
G
V
I
A
A
N
L
L
L
D
D
I
E
K
R
F
V
---
2
PsiBlast_PDB
66.24
41%
-54
- C2 -
3MWF
1
?
A:
[5-287]
--------------------------------------
T
T
S
I
K
H
A
M
-------
G
-
T
T
E
--
I
K
G
K
P
K
R
V
V
T
L
Y
Q
-
G
A
T
D
V
A
V
S
L
G
V
--
K
P
V
G
A
V
E
S
W
T
Q
K
--
P
K
F
-
E
---
Y
I
K
N
---------
D
--
L
-
K
D
T
K
I
V
G
Q
E
P
A
P
N
L
E
E
I
S
K
L
K
P
D
L
I
V
A
-
S
K
V
R
N
E
K
V
Y
D
Q
L
S
K
I
A
P
T
V
S
-----
T
D
T
-----
V
F
-
K
F
----
K
D
T
T
K
L
M
G
K
A
L
----
G
K
--
E
--
K
E
A
E
D
L
L
K
K
Y
D
D
K
V
A
A
F
Q
K
D
A
K
A
K
Y
K
D
A
----
W
-
P
L
K
A
S
V
V
N
F
R
A
-
D
H
T
R
I
-
Y
A
-------
G
G
Y
A
G
----
E
I
L
N
D
L
G
F
K
R
N
K
D
L
Q
K
Q
V
D
-
N
G
K
D
I
I
Q
L
T
--
S
K
E
S
I
P
L
M
N
A
D
H
I
F
V
----
V
--
K
S
D
P
N
A
--
K
D
A
A
L
V
K
K
T
E
S
E
W
T
-
S
-----
S
K
E
W
-
K
N
-
L
D
A
V
K
N
N
Q
V
S
D
D
L
-
D
E
I
T
W
-
N
-
L
-
A
--
G
G
Y
K
S
S
L
K
L
I
D
D
L
--------
46
HHSearch
65.20
26%
-90
- C2 -
4JCC
5
?
A:
[4-285]
------------------------------------
P
T
E
V
T
I
K
S
S
--------
L
-
D
E
V
-
K
L
S
K
V
P
E
K
I
V
T
F
D
L
-
G
A
A
D
T
I
R
A
L
G
F
AK
N
I
V
G
M
P
T
K
T
------
V
P
-
T
---
Y
L
K
D
---------
L
--
V
-
G
T
V
K
N
V
G
S
M
K
E
P
D
L
E
A
I
A
A
L
E
P
D
L
I
I
A
-
S
P
R
T
-
Q
K
F
V
D
K
F
K
E
I
A
P
T
V
L
-----
F
Q
A
S
KDD-
Y
W
T
S
T
----
K
A
N
I
E
S
L
A
S
A
F
----
G
E
--
T
G
T
Q
K
A
K
E
E
L
A
K
L
D
E
S
I
Q
----
E
V
A
T
K
N
E
S
S
------
D
K
K
A
L
A
I
L
L
N
E
-
G
K
M
A
A
F
G
A
-------
K
S
R
F
S
----
F
L
Y
Q
T
L
K
F
K
P
T
D
T
K
F
E
-------
D
S
R
H
G
Q
E
V
S
F
E
S
V
K
E
I
N
P
D
I
L
F
V
----
I
N
R
T
L
A
-
I
G
---
G
D
---
N
S
S
N
D
G
V
L
-
E
-----
N
A
L
I
-
A
E
-
T
P
A
A
K
N
G
K
-
I
I
Q
L
-
T
P
D
L
W
-
Y
-
L
S
G
--
G
G
L
E
S
T
K
L
M
I
E
D
I
Q
K
A
L
----
47
HHSearch
64.68
39%
-53
- C2 -
3MWF
1
?
A:
[5-295]
--------------------------------------
T
T
S
I
K
H
A
M
-------
G
--
T
T
-
E
I
K
G
K
P
K
R
V
V
T
L
Y
Q
-
G
A
T
D
V
A
V
S
L
G
V
--
K
P
V
G
A
V
E
S
W
T
Q
K
--
P
K
F
-
E
---
Y
I
K
N
---------
D
--
L
-
K
D
T
K
I
V
G
Q
E
P
A
P
N
L
E
E
I
S
K
L
K
P
D
L
I
V
A
-
S
K
V
R
N
E
K
V
Y
D
Q
L
S
K
I
A
P
T
V
S
-----
T
D
T
------
V
F
K
F
----
K
D
T
T
K
L
M
G
K
A
L
----
G
K
--
E
--
K
E
A
E
D
L
L
K
K
Y
D
D
K
V
A
----
A
F
Q
K
D
A
K
A
K
YKDA
W
-
P
L
K
A
S
V
V
N
F
R
A
-
D
H
T
R
I
Y
A
--------
G
G
Y
A
G
----
E
I
L
N
D
L
G
F
K
R
N
K
D
L
Q
K
Q
V
---
D
N
G
K
D
I
I
Q
L
T
S
K
E
S
I
P
L
M
N
A
D
H
I
F
V
----
V
K
S
D
P
N
-
A
K
D
A
A
L
V
---
K
K
T
E
S
E
W
T
-
S
-----
S
K
E
W
-
K
N
-
L
D
A
V
K
N
N
Q
-
V
S
D
D
L
D
E
I
T
W
-
N
-
L
-
A
--
G
G
Y
K
S
S
L
K
L
I
D
D
L
Y
E
K
L
N
I
E
K
28
Fugue
63.06
21%
-123
- C2 -
1EFD
1
FHUD_ECOLI
N:
[2-263]
-------------------------------------------------------------
G
I
D
P
N
R
I
V
A
L
E
W
-
L
P
V
E
L
L
L
A
L
G
I
--
V
P
Y
G
V
A
D
T
I
N
Y
R
--
L
W
V
-
S
---
E
-
P
P
---------
L
--
P
-
D
S
V
I
D
V
G
L
R
T
E
P
N
L
E
L
L
T
E
M
K
P
S
F
M
V
W
S
A
G
Y
G
P
--
S
P
E
M
L
A
R
I
A
P
G
R
G
FNFSD
G
K
Q
-----
P
L
A
M
A
----
R
K
S
L
T
E
M
A
D
L
L
----
N
L
--
Q
--
S
A
A
E
T
H
L
A
Q
Y
E
D
F
I
R
----
S
M
K
P
R
F
V
K
R
----
G
-
A
R
P
L
L
L
T
T
L
I
D
P
R
H
M
L
V
F
G
P
-------
N
S
L
F
Q
----
E
I
L
D
E
Y
G
I
P
N
A
------
W
Q
-
G
E
T
N
F
W
G
S
T
A
V
S
I
D
R
L
A
A
Y
K
D
V
D
V
L
C
----
F
------
D
H
---
D
N
---
S
K
D
M
D
A
L
M
-
A
-----
T
P
L
W
-
Q
A
-
M
P
F
V
R
A
G
R
-
F
Q
R
V
-
P
A
V
W
F
-
Y
------
G
A
T
L
S
A
M
H
F
V
R
V
L
D
N
A
I
G
---
51
HHSearch
62.33
25%
-86
- C2 -
3GFV
1
YCLQ_BACSU
A:
[14-298]
------------------------------------
K
E
Q
I
T
V
K
H
Q
L
-------
D
K
N
G
T
-
K
V
P
K
N
P
K
K
V
V
V
F
D
F
-
G
S
L
D
T
L
D
K
L
G
L
DD
I
V
A
G
L
P
K
Q
V
------
L
P
-
K
---
Y
L
S
K
F--------
K
--
D
-
D
K
Y
A
D
V
G
S
L
K
E
P
D
F
D
K
V
A
E
L
D
P
D
L
I
I
I
-
S
A
R
-
Q
S
E
S
Y
K
E
F
S
K
I
A
P
T
I
Y
-----
L
G
V
DTAK-
Y
M
E
S
F
----
K
S
D
A
E
T
I
G
K
I
F
----
D
K
--
E
--
D
K
V
K
D
E
L
A
N
I
D
H
S
I
A
----
D
V
K
K
T
A
E
K
L
----
N
--
K
N
G
L
V
I
M
A
N
D
-
G
K
I
S
A
F
G
P
-------
K
S
R
Y
G
----
L
I
H
D
V
F
G
V
A
P
A
D
Q
N
I
K
-------
A
S
T
H
G
Q
S
V
S
Y
E
Y
I
S
K
T
N
P
D
Y
L
F
V
----
I
D
R
G
T
A
-
I
G
----
E
---
T
S
S
T
K
Q
V
V
-
E
-----
N
D
Y
V
-
K
N
-
V
N
A
V
K
N
G
H
-
V
I
Y
L
-
D
S
A
T
W
-
Y
L
S
-
G
--
G
G
L
E
S
M
T
Q
M
I
K
E
V
K
D
G
L
E
K
E
-
49
HHSearch
59.62
23%
-92
- C2 -
3BE6
2
?
A:
[2-291]
-------------------------------------
P
V
Q
V
F
T
D
D
L
-------
G
-
R
K
V
-
T
V
P
A
H
P
K
R
I
V
S
L
H
D
L
D
I
T
I
P
L
I
E
L
G
V
--
P
P
V
A
S
H
G
R
T
R
P
D
GS
H
F
I
-
R
SGA
L
L
T
G
V--------
D
FD
N
-
S
S
I
A
F
I
G
T
-
A
D
I
D
I
E
A
I
V
A
A
K
P
D
L
I
I
T
-
E
P
T
R
-
N
T
P
I
E
R
L
E
K
I
A
P
T
V
S
-----
I
D
H
-----
L
K
G
G
A
----
P
E
I
Y
R
K
L
A
E
L
T
----
G
T
--
Q
--
S
Q
L
A
I
L
E
R
R
Y
Q
A
Q
I
N
----
A
L
K
A
T
L
D
S
-----
Q
-
K
I
T
V
S
V
I
Q
A
N
Q
-
G
K
I
N
V
M
H
S
-------
Y
H
S
L
G
----
R
V
L
R
D
A
G
F
R
F
P
P
L
I
E
S
I
------
P
E
G
G
R
M
D
V
S
A
E
R
L
P
E
L
D
A
D
F
V
F
A
----
T
W
R
G
D
T
-
G
G
---
K
P
---
Q
D
E
L
A
T
M
E
K
V
-----
M
P
G
W
C
Q
F
-
L
T
A
C
R
S
G
R
-
Y
V
L
I
-
S
R
E
E
A
-
I
-
S
----
N
S
F
A
S
L
G
L
M
A
A
Q
I
Q
S
Q
I
A
G
R
-
3
PsiBlast_PDB
58.89
40%
-59
- C2 -
3MWG
-
?
A:
[54-319]
-----------------------------------------------------------------
K
R
V
V
T
L
Y
Q
-
G
A
T
D
V
A
V
S
L
G
V
--
K
P
V
G
A
V
E
S
W
T
Q
K
--
P
K
F
-
E
---
Y
I
K
N
---------
D
--
L
-
K
D
T
K
I
V
G
Q
E
P
A
P
N
L
E
E
I
S
K
L
K
P
D
L
I
V
A
-
S
K
V
R
N
E
K
V
Y
D
Q
L
S
K
I
A
P
T
V
S
-----
T
D
T
-----
V
F
-
K
F
----
K
D
T
T
K
L
M
G
K
A
L
----
G
K
--
E
--
K
E
A
E
D
L
L
K
K
Y
D
D
K
V
A
A
F
Q
K
D
A
K
A
K
Y
K
D
A
----
W
-
P
L
K
A
S
V
V
N
F
R
A
-
D
H
T
R
I
-
Y
A
-------
G
G
Y
A
G
----
E
I
L
N
D
L
G
F
K
R
N
K
D
L
Q
K
Q
V
D
-
N
G
K
D
I
I
Q
L
T
--
S
K
E
S
I
P
L
M
N
A
D
H
I
------
F
V
V
K
S
D
P
N
A
--
K
D
A
A
L
V
K
K
T
E
S
E
W
T
-
S
-----
S
K
E
W
-
K
N
-
L
D
A
V
K
N
N
Q
V
S
D
D
L
-
D
E
I
T
W
-
N
-
L
-
A
--
G
G
Y
K
S
S
L
K
L
I
D
D
L
--------
29
Fugue
58.58
21%
-111
- C2 -
1EFD
1
FHUD_ECOLI
N:
[2-263]
-------------------------------------------------------------
G
I
D
P
N
R
I
V
A
L
E
W
-
L
P
V
E
L
L
L
A
L
G
I
--
V
P
Y
G
V
A
D
T
I
N
Y
R
--
L
W
V
-
S
---
E
-
P
P
---------
L
--
P
-
D
S
V
I
D
V
G
L
R
T
E
P
N
L
E
L
L
T
E
M
K
P
S
F
M
V
W
-
S
A
-
G
Y
G
P
S
P
E
M
L
A
R
I
A
P
G
R
G
FNFSD
G
K
Q
-----
P
L
A
M
A
----
R
K
S
L
T
E
M
A
D
L
L
----
N
L
--
Q
--
S
A
A
E
T
H
L
A
Q
Y
E
D
F
I
R
----
S
M
K
P
R
F
V
K
R
----
G
-
A
R
P
L
L
L
T
T
L
I
D
P
R
H
M
L
V
F
G
P
-------
N
S
L
F
Q
----
E
I
L
D
E
Y
G
I
P
N
A
W
Q
-------
G
E
T
N
F
W
G
S
T
A
V
S
I
D
R
L
A
A
Y
K
D
V
D
V
L
C
----
F
D
---------
H
D
N
---
S
K
D
M
D
A
L
M
-
A
-----
T
P
L
W
-
Q
A
-
M
P
F
V
R
A
G
R
-
F
Q
R
V
-
P
A
V
W
----
F
-
Y
--
G
A
T
L
S
A
M
H
F
V
R
V
L
D
N
A
I
G
---
54
HHSearch
57.28
24%
-97
- C2 -
5A1J
2
?
A:
[9-287]
-----------------------------------
E
G
D
S
F
L
V
K
D
S
L
-------
G
-
E
-
N
-
K
I
P
K
N
P
S
K
V
V
I
L
D
L
-
G
I
L
D
T
F
D
A
L
K
L
ND
K
V
V
G
V
P
A
K
N
------
L
P
-
K
----
Y
L
Q
---------
Q
--
F
-
K
N
K
P
S
V
G
G
V
Q
Q
V
D
F
E
A
I
N
A
L
K
P
D
L
I
I
I
-
S
G
R
-
Q
S
K
F
Y
D
K
L
K
E
I
A
P
T
L
F
-----
V
G
L
DNAN-
F
L
S
S
F
----
E
N
N
V
L
S
V
A
K
L
Y
----
G
L
--
E
--
K
E
A
L
E
K
I
S
D
I
K
N
E
I
E
----
K
A
K
S
I
V
D
E
-------
D
K
K
A
L
I
I
L
T
N
S
-
N
K
I
S
A
F
G
P
-------
Q
S
R
F
G
----
I
I
H
D
V
L
G
I
N
A
V
D
E
N
I
K
-------
V
G
T
H
G
K
S
I
N
S
E
F
I
L
E
K
N
P
D
Y
I
F
V
----
V
D
R
N
V
I
-
L
G
----
N
---
K
E
R
A
Q
G
I
L
-
D
-----
N
A
L
V
-
A
K
-
T
K
A
A
Q
N
K
K
-
I
I
Y
L
-
D
P
E
Y
W
-
Y
-
L
-
A
SG
N
G
L
E
S
L
K
T
M
I
L
E
I
K
N
A
V
----
14
PsiBlast_PDB
56.97
29%
-79
- C2 -
5FLY
13
?
A:
[5-257]
------------------------------------
T
K
A
F
N
L
K
T
A
K
-------
G
-
E
E
K
I
D
I
P
K
D
P
K
R
I
V
V
M
A
P
-
T
Y
A
G
G
L
K
Y
L
D
A
--
N
I
V
G
V
S
D
Q
V
D
Q
S
--
P
-------
V
L
A
K
---------
Q
--
F
-
K
D
V
D
K
V
G
A
E
---
D
V
E
K
V
A
S
L
K
P
D
L
I
I
T
---
Y
N
T
D
K
N
T
D
K
L
K
K
I
A
P
T
I
A
-----
F
D
Y
-----
A
K
Y
N
Y
----
L
E
Q
Q
E
A
M
G
D
I
V
----
G
K
--
S
--
D
E
V
K
K
W
K
A
D
W
E
K
Q
T
A
Q
D
S
K
D
I
K
A
H
L
G
D
D
----
T
-----
S
V
T
I
F
E
D
-
F
D
K
K
I
Y
A
Y
-------
G
K
N
W
G
RGSE
V
L
Y
Q
A
F
G
L
Q
M
P
K
A
L
D
D
A
T
K
-
K
E
----
G
W
T
E
V
P
K
E
E
V
G
K
Y
A
G
D
V
I
------
I
T
A
K
A
K
-
D
A
--
A
Q
P
---
E
-----
F
Q
-
K
-----
T
A
M
W
-
Q
N
-
L
E
A
V
Q
N
K
Y
-
A
F
N
V
-
D
S
S
V
Y
-----------------------------
37
HHSearch
53.89
19%
-92
- C- -
4MX8
-
?
A:
[12-312]
------------------------------P
A
T
A
S
Y
T
W
D
R
N
T
A
T
E
E
GAD
P
V
Y
E
E
-
T
T
V
-
E
V
P
V
D
P
Q
R
I
V
V
F
D
M
-
A
A
L
D
T
I
G
A
L
G
G
--
E
I
A
G
A
P
L
D
S
------
V
P
-
D
---
Y
L
E
E
---------
Y
--
L
A
D
D
A
F
N
A
G
T
L
F
E
A
D
L
I
A
I
E
A
Q
Q
P
D
L
I
V
V
-
G
G
R
-
S
S
G
L
W
A
D
L
N
E
I
A
P
T
I
D
-----
L
S
L
RGS--
Y
L
D
T
L
----
E
Q
N
T
T
F
L
G
K
V
L
----
G
A
--
E
--
A
E
A
E
S
V
L
A
E
L
E
A
G
I
A
----
E
A
K
A
A
V
T
E
A
----
S
-
G
T
G
L
G
I
M
V
-
S
G
-
G
Q
L
S
A
L
S
P
NTGNDPR
G
A
R
G
G
----
L
I
Y
D
V
F
G
V
Q
P
V
L
E
D
I
K
-------
A
A
T
H
G
E
P
I
S
F
E
F
L
L
E
H
D
P
Q
W
L
W
V
----
V
D
R
D
A
A
-
T
G
--
A
E
G
---
A
Q
A
A
K
V
V
L
-
D
-----
N
E
I
V
-
N
R
-
T
T
A
A
T
E
D
H
-
V
L
Y
L
-
N
P
T
A
W
-
Y
I
V
-
F
--
G
G
V
E
T
T
R
I
M
I
D
D
V
L
Q
V
A
A
---
18
PsiBlast_PDB
53.67
29%
-83
- C2 -
3G9Q
-
FHUD_BACSU
A:
[54-292]
------------------------------------------------------------
I
P
K
H
P
K
R
V
V
V
M
A
D
-
G
Y
Y
G
Y
F
K
T
L
G
I
--
N
V
V
G
A
P
E
N
V
F
K
N
--
P
Y
Y
-------
K
G
---------
K
--
T
-
N
G
V
E
N
I
G
D
G
T
--
S
V
E
K
V
I
D
L
N
P
D
L
I
I
V
-
W
T
T
--
A
D
I
-
K
K
L
E
K
I
A
P
T
V
A
-----
V
K
Y
-----
D
K
L
D
N
----
I
E
Q
L
K
E
F
A
K
M
T
----
G
T
--
E
--
D
K
A
E
K
W
L
A
K
W
D
K
K
V
A
----
A
A
K
T
K
I
K
K
A
----
V
G
D
K
T
I
S
I
M
Q
T
N
G
-
K
D
I
Y
V
F
G
K
-------
D
F
G
R
G
GS--
I
I
Y
K
D
L
G
L
Q
A
T
K
L
T
K
E
K
A
I
-
D
Q
G
P
G
Y
T
--
S
I
S
L
E
K
L
P
D
F
A
G
D
Y
I
F
-------------------------
A
G
P
W
Q
-
S
GGVFE
S
S
I
W
-
K
N
-
L
N
A
V
K
N
G
H
-
V
Y
K
M
-
D
P
I
-------------------------------
20
PsiBlast_PDB
53.44
26%
-85
- C2 -
3BE6
2
?
A:
[10-260]
---------------------------------------------
L
-------
G
-
R
K
V
-
T
V
P
A
H
P
K
R
I
V
S
L
H
D
L
D
I
T
I
P
L
I
E
L
G
V
--
P
P
V
A
S
H
G
R
T
R
P
D
--
G
S
H
-----
F
I
R
S
GALLTGVDF
D
--
N
-
S
S
I
A
F
I
G
-
T
A
D
I
D
I
E
A
I
V
A
A
K
P
D
L
I
I
T
-
E
P
T
R
N
T
P
I
-
E
R
L
E
K
I
A
P
T
V
S
-----
I
D
H
-----
L
K
G
G
A
----
P
E
I
Y
R
K
L
A
E
L
T
----
G
T
--
Q
--
S
Q
L
A
I
L
E
R
R
Y
Q
A
Q
I
N
----
A
L
K
A
T
L
-
D
S
----
Q
-
K
I
T
V
S
V
I
Q
A
N
Q
-
G
K
I
N
V
M
H
S
-------
Y
H
S
L
G
----
R
V
L
R
D
A
G
F
R
F
P
P
L
I
E
S
I
P
E
-
G
G
R
M
D
V
-----
S
A
E
R
L
P
E
L
D
A
D
F
V
F
A
-----
T
W
R
G
D
T
G
G
--
K
P
Q
---
D
E
L
A
T
M
E
K
-
V
-----
M
P
G
W
-
C
Q
F
L
T
A
C
R
S
G
R
----------------------------------------
19
PsiBlast_PDB
53.17
26%
-86
- C2 -
3BE5
-
?
A:
[10-260]
---------------------------------------------
L
-------
G
-
R
K
V
-
T
V
P
A
H
P
K
R
I
V
S
L
H
D
L
D
I
T
I
P
L
I
E
L
G
V
--
P
P
V
A
S
H
G
R
T
R
P
D
--
G
S
H
-----
F
I
R
S
GALLTGVDF
D
--
N
-
S
S
I
A
F
I
G
-
T
A
D
I
D
I
E
A
I
V
A
A
K
P
D
L
I
I
T
-
E
P
T
R
N
T
P
I
-
E
R
L
E
K
I
A
P
T
V
S
-----
I
D
H
-----
L
K
G
G
A
----
P
E
I
Y
R
K
L
A
E
L
T
----
G
T
--
Q
--
S
Q
L
A
I
L
E
R
R
Y
Q
A
Q
I
N
----
A
L
K
A
T
L
-
D
S
----
Q
-
K
I
T
V
S
V
I
Q
A
N
Q
-
G
K
I
N
V
M
H
S
-------
Y
H
S
L
G
----
R
V
L
R
D
A
G
F
R
F
P
P
L
I
E
S
I
P
E
-
G
G
R
M
D
V
-----
S
A
E
R
L
P
E
L
D
A
D
F
V
F
A
-----
T
W
R
G
D
T
G
G
--
K
P
Q
---
D
E
L
A
T
M
E
K
-
V
-----
M
P
G
W
-
C
Q
F
L
T
A
C
R
S
G
R
----------------------------------------
13
PsiBlast_PDB
52.81
26%
-80
- C2 -
4JCC
5
?
A:
[22-282]
----------------------------------------------------------------
P
E
K
I
V
T
F
D
L
-
G
A
A
D
T
I
R
A
L
G
F
-------
A
K
N
I
V
G
M
--
P
T
K
-
T
VPT
Y
L
K
D
---------
L
--
V
-
G
T
V
K
N
V
G
S
M
K
E
P
D
L
E
A
I
A
A
L
E
P
D
L
I
I
A
-
S
P
-
R
T
Q
K
F
V
D
K
F
K
E
I
A
P
T
V
L
-----
F
Q
A
-----
S
K
D
D
Y
W
T
S
T
K
A
N
I
E
S
L
A
S
A
F
----
G
E
T
G
T
--
Q
K
A
K
E
E
L
A
K
L
D
E
S
I
Q
----
E
V
A
T
K
-
N
E
S
----
S
-
D
K
K
A
L
A
I
L
L
N
E
-
G
K
M
A
A
F
G
A
-------
K
S
R
F
S
----
F
L
Y
Q
T
L
K
F
K
P
T
D
T
K
F
E
-
D
S
-
R
H
G
Q
E
V
S
F
-----
E
S
V
K
E
I
N
P
D
I
L
F
V
I
N
R
T
L
A
I
G
G
D
-
N
S
--
S
N
D
---
G
V
L
E
N
-----------
A
L
I
-
A
E
-
T
P
A
A
K
N
G
K
-
I
I
Q
L
-
T
P
D
L
W
Y
L
-
S
-
G
--
G
G
L
E
S
T
K
L
M
I
E
D
I
Q
-------
36
HHSearch
52.67
27%
-63
* C2 *
3LHS
4
?
A:
[5-294]
------------------------------------
A
S
T
I
S
V
K
D
E
N
-------
G
--
T
V
-
K
V
P
K
D
A
K
R
I
V
V
L
E
Y
-
S
F
A
D
A
L
A
A
L
D
V
--
K
P
V
G
I
A
D
D
G
K
K
K
--
R
I
I
-
K
---
P
V
R
E
---------
K
--
I
-
G
D
Y
T
S
V
G
T
R
K
Q
P
N
L
E
E
I
S
K
L
K
P
D
L
I
I
A
-
D
S
S
R
H
K
G
I
N
K
E
L
N
K
I
A
P
T
L
S
-----
L
K
S
FDG--
D
Y
K
Q
N
----
I
N
S
F
K
T
I
A
K
A
L
----
N
K
--
E
--
K
E
G
E
K
R
L
A
E
H
D
K
L
I
N
----
K
Y
K
D
E
I
K
F
D
----
R
-
N
Q
K
V
L
P
A
V
V
A
K
-
A
G
L
L
A
H
P
N
-------
Y
S
Y
V
G
----
Q
F
L
N
E
L
G
F
K
N
A
L
S
D
D
V
T
K
G
L
S
K
Y
L
K
G
P
Y
L
Q
L
D
T
E
H
L
A
D
L
N
P
E
R
M
I
I
----
M
T
D
H
A
K
-
K
D
--------
S
A
E
F
K
K
L
Q
-
E
-----
D
A
T
W
-
K
K
-
L
N
A
V
K
N
N
R
-
V
D
I
V
-
D
R
D
V
W
-
A
-
R
-
S
--
R
G
L
I
S
S
E
E
M
A
K
E
L
V
E
L
S
K
K
E
-
8
PsiBlast_PDB
52.67
28%
-73
- C2 -
3GFV
1
YCLQ_BACSU
A:
[14-279]
-----------------------------------
K
E
Q
I
-
T
V
K
H
Q
L
DKN----
G
-
T
---
K
V
P
K
N
P
K
K
V
V
V
F
D
F
-
G
S
L
D
T
L
D
K
L
G
L
--
D
D
I
V
A
G
L
P
K
Q
V
L
--
P
K
Y
L
S
---
K
F
K
D
---------
D
--
K
---
Y
A
D
V
G
S
L
K
E
P
D
F
D
K
V
A
E
L
D
P
D
L
I
I
I
-
S
-
A
R
Q
S
E
S
Y
K
E
F
S
K
I
A
P
T
I
Y
-----
L
G
V
-----
D
T
A
K
Y
----
M
E
S
F
K
S
D
A
E
T
I
G
K
I
F
D
K
--
E
--
D
K
V
K
D
E
L
A
N
I
D
H
S
I
A
----
D
V
K
-
K
T
A
E
K
----
L
-
N
K
N
G
L
V
I
M
A
N
D
-
G
K
I
S
A
F
G
P
-------
K
S
R
Y
G
----
L
I
H
D
V
F
G
V
A
P
A
D
Q
N
I
-------
K
A
S
T
H
G
Q
S
V
S
Y
E
Y
I
S
K
T
N
P
D
Y
L
F
V
----
I
D
--
R
G
-
T
A
--
I
G
E
---
T
S
S
T
K
Q
V
V
-
E
-----
N
D
Y
V
-
K
N
-
V
N
A
V
K
N
G
H
-
V
I
Y
L
-
D
S
A
T
W
-
Y
-
L
-
S
--
G
G
-------------------
41
HHSearch
52.41
22%
-74
- C2 -
3TEF
-
?
A:
[51-329]
-------------------------------------
E
T
V
T
I
E
H
R
L
-------
G
-
K
-
T
-
T
L
E
Q
K
P
Q
R
V
V
V
I
G
V
-
G
A
L
D
A
I
D
S
F
G
I
--
E
P
V
A
V
S
K
F
D
G
-----
T
P
-
D
---
Y
L
A
K
Y--------
K
--
S
-
D
K
Y
P
S
A
G
S
L
F
E
P
D
F
E
T
I
Y
T
Q
K
P
D
L
I
V
I
-
G
P
R
A
-
S
K
S
Y
D
E
L
S
K
I
A
P
T
I
V
-----
F
A
A
E
ADQG
Y
W
E
S
T
----
Q
Q
Q
W
R
N
L
G
K
V
F
----
A
I
--
E
--
P
A
V
E
A
K
I
E
Q
V
D
A
Q
F
K
----
S
I
M
Q
Y
N
Q
Q
-----
H
-
K
S
D
A
M
L
V
M
S
S
G
-
G
N
L
T
T
F
G
A
-------
N
S
R
F
S
----
S
V
Y
K
D
F
G
F
S
E
T
V
P
V
S
K
-------
E
S
S
H
G
D
L
I
S
F
E
Y
I
R
E
H
N
P
K
T
L
L
V
----
V
D
R
D
K
V
-
V
T
---
K
G
---
E
T
N
I
R
Q
T
F
-
E
-----
N
D
L
V
-
K
A
-
T
T
A
Y
K
N
G
H
-
I
A
Y
L
-
D
V
N
A
W
-
Y
-
I
-
A
I-
S
G
V
K
A
T
E
Q
M
V
A
D
M
K
A
S
-----