@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu08470: (2016-06-13 )
MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAGYSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKAGILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTGIWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSPYSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVKVNMTGTAVYSETRILKI
Atome Classification :
(20 SA)
---------..-.......10........20.....----..----.---30..---------------...-...40.---.......---50--....--.-...60......-..70........80........90........100........110..-..-....120.....--.-.--130.-.--......140--.......150.......160...-....170--...--......180.......190-------........200....-....210..-...-..-220........230-..-.....240-.---...---.-..-250..----......-260........-----270..-...-....280.......290.----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MK-E
A
E
V
L
K
Y
EAFTSSPGKGNP
A
G
V
V
L
----QG----D---DY
T
E
---------------
D
E
M
-
Q
I
I
A
E
R---AGYSET
S
---
F
I
--RKSE--S-A
D
L
E
L
R
Y
FTPG-HEMNLC
G
H
A
T
V
A
S
L
Y
A
L
C
E
K
G
M
LESG
K
T
Y
S
I
Q
TK-A
G
I
L
P
V
K
IS-EKD-
G
R
-
I
H
I
T
LEQASPQF--K-P--F-TG-
D
--
R
K
K
L
A
D
A
LG--IT
D
E
D
F
HEDL
P
I
V
FGSTG
I
W
T
A
I
-
V
P
L
K
S
----LEA--SKKMVPDNKQ
F
P
E
V
L
V
DL--------PKASVH
P
F
T
F
-
E
TVH-PDSDLHGRH-FSS-PY-S-GTIEDPVTGT
A
S
-
G
V
-
M
G
A
Y
M
K
HY-G---
N
A
E
---
Q
-
H
K
-
F
I
-
I
E
----
Q
G
Q
EIG-KD-
G
K
V
E
I
E
MN-----E--AG-
G
H
V
-
K
V
N
M
T
G
T
A
V
YS
E
T
R
I
L
KI----
53
HHSearch
86.35
50%
-75
- C4 -
3EDN
10
?
A:
[1-299]
---------
M
K
-
T
I
N
V
F
H
Y
D
A
F
T
N
K
P
N
M
G
N
P
A
G
I
V
L
----
D
A
----
D
---
G
L
T
E
---------------
E
E
M
-
Q
R
I
A
E
K
---
V
G
F
N
E
T
S
---
F
V
--
L
S
S
E
--
V
-
A
D
I
R
M
R
Y
F
T
P
G
-
Y
E
M
D
L
C
G
H
G
T
V
G
T
I
Y
A
L
R
E
R
G
L
L
E
E
K
A
S
L
T
I
E
T
K
-
A
G
I
L
P
I
Q
I
G
-
V
N
E
N
G
E
-
T
F
I
K
M
R
Q
T
A
P
Q
F
--
K
-
D
--
F
-
A
G
-
S
--
K
E
E
L
A
H
S
I
G
--
L
E
V
N
D
L
D
V
S
L
P
I
V
Y
G
S
T
G
N
W
T
V
I
-
V
P
V
K
N
----
L
D
V
--
C
E
R
M
K
P
N
N
E
V
F
P
S
V
L
K
E
I
--------
P
N
A
S
I
H
P
I
C
L
-
E
T
Y
D
-
E
K
V
H
M
H
G
R
H
-
F
S
--
S
A
Y
A
-
G
T
I
E
D
P
V
T
G
T
A
S
-
G
V
-
M
G
A
Y
Y
A
T
Y
-
V
---
E
K
D
FDH
E
-
M
E
-
L
I
-
V
E
----
Q
G
Q
E
I
H
-
K
D
-
G
R
V
T
V
Y
V
T
-----
K
--
D
V
E
S
E
K
L
Q
I
D
I
A
G
T
A
V
Y
V
K
E
F
E
V
L
I
----
1
PsiBlast_PDB
85.97
49%
-74
- C4 -
3EDN
10
?
A:
[2-291]
----------
K
-
T
I
N
V
F
H
Y
D
A
F
T
N
K
P
N
M
G
N
P
A
G
I
V
L
----
D
A
----
D
---
G
L
T
E
---------------
E
E
M
-
Q
R
I
A
E
K
---
V
G
F
N
E
T
S
---
F
V
--
L
S
S
E
--
V
-
A
D
I
R
M
R
Y
F
T
P
G
-
Y
E
M
D
L
C
G
H
G
T
V
G
T
I
Y
A
L
R
E
R
G
L
L
E
E
K
A
S
L
T
I
E
T
K
-
A
G
I
L
P
I
Q
I
G
V
N
E
N
-
G
E
-
T
F
I
K
M
R
Q
T
A
P
Q
F
--
K
-
D
--
F
-
A
G
-
S
--
K
E
E
L
A
H
S
I
G
--
L
E
V
N
D
L
D
V
S
L
P
I
V
Y
G
S
T
G
N
W
T
V
I
-
V
P
V
K
N
----
L
D
V
--
C
E
R
M
K
P
N
N
E
V
F
P
S
V
L
K
E
I
--------
P
N
A
S
I
H
P
I
C
L
-
E
T
Y
D
-
E
K
V
H
M
H
G
R
H
-
F
S
S
-
A
Y
-
A
-
G
T
I
E
D
P
V
T
G
T
A
S
-
G
V
-
M
G
A
Y
Y
A
T
Y
-
V
---
E
K
D
FDH
E
-
M
E
-
L
I
-
V
E
----
Q
G
Q
E
I
H
-
K
D
-
G
R
V
T
V
Y
V
T
-----
K
D
V
E
S
-
E
K
L
-
Q
I
D
I
A
G
T
A
V
Y
------------
2
PsiBlast_PDB
74.79
35%
-76
- C4 -
1QY9
2
YDDE_ECOLI
A:
[4-286]
--------------
Q
V
Y
H
V
D
A
F
T
S
Q
P
F
R
G
N
S
A
G
V
V
F
----
P
A
----
D
---
N
L
S
E
---------------
A
Q
M
-
Q
L
I
A
R
E
---
L
G
H
S
E
T
A
---
F
L
--
L
H
S
D
--
D
-
S
D
V
R
I
R
Y
F
T
P
T
-
V
E
V
P
I
C
G
H
A
T
V
A
A
H
Y
V
R
A
K
--
V
L
G
L
G
N
C
T
I
W
Q
T
S
L
A
G
K
H
R
V
T
I
E
-
K
H
N
-
D
D
-
Y
R
I
S
L
E
Q
G
T
P
G
F
--
E
P
P
--
L
-
E
G
-
E
T
-
R
A
A
I
I
N
A
L
H
--
L
T
E
D
D
I
L
P
G
L
P
I
Q
V
A
T
T
G
H
S
K
V
M
-
I
P
L
K
P
----
E
V
D
--
I
D
A
L
S
P
D
L
N
A
L
T
A
I
S
K
K
I
--------
G
C
N
G
F
F
P
F
Q
I
-
R
P
G
K
-
N
E
T
D
--
G
R
M
-
F
-
S
-
P
A
-
I
-
G
I
V
E
D
P
V
T
G
N
A
N
-
G
P
-
M
G
A
W
L
V
H
H
-
N
---
V
L
P
---
H
-
D
G
-
N
V
-
L
R
V
K
G
H
Q
G
R
A
L
G
-
R
D
-
G
M
I
E
V
T
V
T
-----
I
--
R
D
-
N
Q
P
E
K
V
T
I
S
G
T
A
V
-------------
3
PsiBlast_PDB
74.36
35%
-72
- C4 -
1SDJ
5
YDDE_ECOLI
A:
[15-297]
--------------
Q
V
Y
H
V
D
A
F
T
S
Q
P
F
R
G
N
S
A
G
V
V
F
----
P
A
----
D
---
N
L
S
E
---------------
A
Q
M
-
Q
L
I
A
R
E
---
L
G
H
S
E
T
A
---
F
L
--
L
H
S
D
--
D
-
S
D
V
R
I
R
Y
F
T
P
T
-
V
E
V
P
I
C
G
H
A
T
V
A
A
H
Y
V
R
A
K
--
V
L
G
L
G
N
C
T
I
W
Q
T
S
L
A
G
K
H
R
V
T
I
E
-
K
H
N
-
D
D
-
Y
R
I
S
L
E
Q
G
T
P
G
F
--
E
P
P
--
L
-
E
G
-
E
T
-
R
A
A
I
I
N
A
L
H
--
L
T
E
D
D
I
L
P
G
L
P
I
Q
V
A
T
T
G
H
S
K
V
M
-
I
P
L
K
P
----
E
V
D
--
I
D
A
L
S
P
D
L
N
A
L
T
A
I
S
K
K
I
--------
G
C
N
G
F
F
P
F
Q
I
-
R
P
G
K
-
N
E
T
D
--
G
R
M
-
F
-
S
-
P
A
-
I
-
G
I
V
E
D
P
V
T
G
N
A
N
-
G
P
-
M
G
A
W
L
V
H
H
-
N
---
V
L
P
---
H
-
D
G
-
N
V
-
L
R
V
K
G
H
Q
G
R
A
L
G
-
R
D
-
G
M
I
E
V
T
V
T
-----
I
--
R
D
-
N
Q
P
E
K
V
T
I
S
G
T
A
V
-------------
56
HHSearch
67.09
25%
-82
- C4 -
1XUB
1
PHZF_PSEFL
A:
[21-298]
------------
M
H
N
Y
V
I
I
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
F
----
D
A
----
D
---
D
L
P
P
---------------
A
Q
M
-
Q
R
I
A
R
E
---
M
N
L
S
E
S
T
---
F
V
--
L
K
P
R
N-
G
-
G
D
A
L
I
R
I
F
T
P
V
-
N
E
L
P
F
A
G
A
P
L
L
G
T
A
I
A
L
G
A
H
T
D
N
---
H
R
L
Y
L
E
T
Q
-
M
G
T
I
A
F
E
L
E
-
R
Q
N
G
S
V
-
I
A
A
S
M
D
Q
P
I
P
T
W
--
T
-
A
--
L
-
G
--
R
--
D
A
E
L
L
K
A
L
G
--
I
S
D
S
----
T
F
P
I
E
I
Y
H
N
G
P
R
H
V
F
-
V
G
L
P
S
----
I
D
A
--
L
S
A
L
H
P
D
H
R
A
L
S
N
F
H
D
------------
M
A
I
N
C
F
A
G
-
A
-----
G
R
R
W
R
S
R
M
-
F
S
--
P
A
-
Y
-
G
V
V
E
D
A
A
T
G
S
A
A
-
G
P
-
L
A
I
H
L
A
R
H
-
G
---
Q
I
E
F--
G
-
Q
P
-
V
E
-
I
L
----
Q
G
V
E
I
G
-
R
P
-
S
L
M
F
A
K
A
E
-----
G
--
R
A
-
E
Q
L
T
R
V
E
V
S
G
N
G
V
T
F
G
R
G
T
I
V
L
----
43
Fugue
65.72
31%
-63
* C4 *
1SDJ
5
YDDE_ECOLI
A:
[1-310]
S
G
R
E
N
L
Y
F
Q
G
H
M
K
P
Q
V
Y
H
V
D
A
F
T
S
Q
P
F
R
G
N
S
A
G
V
V
F
----
P
A
----
D
---
N
L
S
----------------
E
A
Q
M
Q
L
I
A
R
E
---
L
G
H
S
E
T
A
---
F
L
--
L
H
S
D
--
D
-
S
D
V
R
I
R
Y
F
T
P
T
-
V
E
V
P
I
C
G
H
A
T
V
A
A
H
Y
V
R
A
K
V
L
-
G
L
G
N
C
T
I
W
Q
T
S
L
-
A
G
K
H
R
V
T
I
E
-
K
H
N
-
D
D
-
Y
R
I
S
L
E
Q
G
T
P
G
F
--
E
-
P
PL
E
-
G
E
-
T
--
R
A
A
I
I
N
A
L
H
--
L
T
E
D
D
I
L
P
G
L
P
I
Q
V
A
T
T
G
H
S
-
K
V
M
I
P
L
K
P
----
E
V
D
--
I
D
A
L
S
P
D
L
N
A
L
T
A
I
S
K
K
I
-----------
G
C
N
G
F
F
P
-
F
Q
I
R
-
P
G
K
N
E
T
D
G
R
M
F
S
--
P
A
-
I
-
G
I
V
E
D
P
V
T
G
N
A
N
-
G
P
M
G
A
W
L
V
H
H
N
-
V
L
P
H
D
G
N
---
V
-
L
R
-
V
K
-
G
H
----
Q
G
R
A
L
G
R
D
G
M
I
E
V
T
V
T
I
R
-----
D
---
N
-
Q
P
E
-
K
V
T
I
S
G
T
A
V
I
L
F
H
A
E
W
A
I
ELGS
7
PsiBlast_PDB
61.36
28%
-79
- C4 -
1XUA
1
PHZF_PSEFL
A:
[28-264]
-------------------
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
F
----
D
A
----
D
---
D
L
P
P
---------------
A
Q
M
-
Q
R
I
A
R
E
---
M
N
L
S
E
S
T
---
F
V
--
L
K
P
R
--
N
G
G
D
A
L
I
R
I
F
T
P
V
-
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
---
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
-
M
G
T
I
A
F
E
L
E
-
R
Q
N
-
G
S
V
I
A
A
S
M
D
Q
P
I
P
T
W
--
T
-
A
--
L
--
G
-
R
--
D
A
E
L
L
K
A
L
G
--
I
S
D
S
T
F
----
P
I
E
I
Y
H
N
G
P
R
H
V
F
-
V
G
L
P
S
----
I
D
A
--
L
S
A
L
H
P
D
H
R
----
A
L
S
N
F
--------
H
D
M
A
I
N
C
F
A
-----
G
-
A
G
R
R
W
R
S
R
M
-
F
S
P
-
A
Y
---
G
V
V
E
D
A
A
T
G
S
A
A
-
G
P
-
L
A
I
H
L
A
R
H
-
G
---
Q
I
E
---
F
-
G
Q
-
P
V
E
I
L
----
Q
G
V
E
I
G
-
R
-----------------------------------------------
4
PsiBlast_PDB
61.31
28%
-82
- C4 -
1T6K
2
PHZF_PSEFL
A:
[8-244]
-------------------
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
F
----
D
A
----
D
---
D
L
P
P
---------------
A
Q
M
-
Q
R
I
A
R
E
---
M
N
L
S
E
S
T
---
F
V
--
L
K
P
R
--
N
G
G
D
A
L
I
R
I
F
T
P
V
-
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
---
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
-
M
G
T
I
A
F
E
L
E
-
R
Q
N
-
G
S
V
I
A
A
S
M
D
Q
P
I
P
T
W
--
T
-
A
--
L
--
G
-
R
--
D
A
E
L
L
K
A
L
G
--
I
S
D
S
T
F
----
P
I
E
I
Y
H
N
G
P
R
H
V
F
-
V
G
L
P
S
----
I
D
A
--
L
S
A
L
H
P
D
H
R
----
A
L
S
N
F
--------
H
D
M
A
I
N
C
F
A
-----
G
-
A
G
R
R
W
R
S
R
M
-
F
S
P
-
A
Y
---
G
V
V
E
D
A
A
T
G
S
A
A
-
G
P
-
L
A
I
H
L
A
R
H
-
G
---
Q
I
E
---
F
-
G
Q
-
P
V
E
I
L
----
Q
G
V
E
I
G
-
R
-----------------------------------------------
8
PsiBlast_PDB
61.24
28%
-83
- C4 -
1U1V
3
PHZF_PSEFL
A:
[28-264]
-------------------
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
F
----
D
A
----
D
---
D
L
P
P
---------------
A
Q
M
-
Q
R
I
A
R
E
---
M
N
L
S
E
S
T
---
F
V
--
L
K
P
R
--
N
G
G
D
A
L
I
R
I
F
T
P
V
-
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
---
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
-
M
G
T
I
A
F
E
L
E
-
R
Q
N
-
G
S
V
I
A
A
S
M
D
Q
P
I
P
T
W
--
T
-
A
--
L
--
G
-
R
--
D
A
E
L
L
K
A
L
G
--
I
S
D
S
T
F
----
P
I
E
I
Y
H
N
G
P
R
H
V
F
-
V
G
L
P
S
----
I
D
A
--
L
S
A
L
H
P
D
H
R
----
A
L
S
N
F
--------
H
D
M
A
I
N
C
F
A
G
-
A
-----
G
R
R
W
R
S
R
M
-
F
S
P
-
A
Y
---
G
V
V
E
D
A
A
T
G
S
A
A
-
G
P
-
L
A
I
H
L
A
R
H
-
G
---
Q
I
E
---
F
-
G
Q
-
P
V
E
I
L
----
Q
G
V
E
I
G
-
R
-----------------------------------------------
5
PsiBlast_PDB
60.69
28%
-75
- C4 -
1U1W
4
PHZF_PSEFL
A:
[28-264]
-------------------
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
F
----
D
A
----
D
---
D
L
P
P
---------------
A
Q
M
-
Q
R
I
A
R
E
---
M
N
L
S
E
S
T
---
F
V
--
L
K
P
R
--
N
G
G
D
A
L
I
R
I
F
T
P
V
-
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
---
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
-
M
G
T
I
A
F
E
L
E
-
R
Q
N
-
G
S
V
I
A
A
S
M
D
Q
P
I
P
T
W
--
T
-
A
--
L
--
G
-
R
--
D
A
E
L
L
K
A
L
G
--
I
S
D
S
T
F
----
P
I
E
I
Y
H
N
G
P
R
H
V
F
-
V
G
L
P
S
----
I
D
A
--
L
S
A
L
H
P
D
H
R
----
A
L
S
N
F
--------
H
D
M
A
I
N
C
F
A
-----
G
-
A
G
R
R
W
R
S
R
M
-
F
S
P
-
A
Y
---
G
V
V
E
D
A
A
T
G
S
A
A
-
G
P
-
L
A
I
H
L
A
R
H
-
G
---
Q
I
E
---
F
-
G
Q
-
P
V
E
I
L
----
Q
G
V
E
I
G
-
R
-----------------------------------------------
9
PsiBlast_PDB
60.60
28%
-79
- C4 -
1XUB
1
PHZF_PSEFL
A:
[28-264]
-------------------
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
F
----
D
A
----
D
---
D
L
P
P
---------------
A
Q
M
-
Q
R
I
A
R
E
---
M
N
L
S
E
S
T
---
F
V
--
L
K
P
R
--
N
G
G
D
A
L
I
R
I
F
T
P
V
-
N
E
L
P
F
A
G
A
P
L
L
G
T
A
I
A
L
---
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
-
M
G
T
I
A
F
E
L
E
-
R
Q
N
-
G
S
V
I
A
A
S
M
D
Q
P
I
P
T
W
--
T
-
A
--
L
--
G
-
R
--
D
A
E
L
L
K
A
L
G
--
I
S
D
S
T
F
----
P
I
E
I
Y
H
N
G
P
R
H
V
F
-
V
G
L
P
S
----
I
D
A
--
L
S
A
L
H
P
D
H
R
----
A
L
S
N
F
--------
H
D
M
A
I
N
C
F
A
-----
G
-
A
G
R
R
W
R
S
R
M
-
F
S
P
-
A
Y
---
G
V
V
E
D
A
A
T
G
S
A
A
-
G
P
-
L
A
I
H
L
A
R
H
-
G
---
Q
I
E
---
F
-
G
Q
-
P
V
E
I
L
----
Q
G
V
E
I
G
-
R
-----------------------------------------------
6
PsiBlast_PDB
60.12
28%
-73
- C4 -
1U1X
1
PHZF_PSEFL
A:
[28-264]
-------------------
D
A
F
A
S
V
P
L
E
G
N
P
V
A
V
F
F
----
D
A
----
D
---
D
L
P
P
---------------
A
Q
M
-
Q
R
I
A
R
E
---
M
N
L
S
E
S
T
---
F
V
--
L
K
P
R
--
N
G
G
D
A
L
I
R
I
F
T
P
V
-
N
E
L
P
F
A
G
H
P
L
L
G
T
A
I
A
L
---
G
A
H
T
D
N
H
R
L
Y
L
E
T
Q
-
M
G
T
I
A
F
E
L
E
-
R
Q
N
-
G
S
V
I
A
A
S
M
D
Q
P
I
P
T
W
--
T
-
A
--
L
--
G
-
R
--
D
A
E
L
L
K
A
L
G
--
I
S
D
S
T
F
----
P
I
E
I
Y
H
N
G
P
R
H
V
F
-
V
G
L
P
S
----
I
D
A
--
L
S
A
L
H
P
D
H
R
----
A
L
S
N
F
--------
H
D
M
A
I
N
C
F
A
-----
G
-
A
G
R
R
W
R
S
R
M
-
F
S
P
-
A
Y
---
G
V
V
E
D
A
A
T
G
S
A
A
-
G
P
-
L
A
I
H
L
A
R
H
-
G
---
Q
I
E
---
F
-
G
Q
-
P
V
E
I
L
----
Q
G
V
E
I
G
-
R
-----------------------------------------------
55
HHSearch
59.00
21%
-81
- C4 -
1YM5
-
YHI9_YEAST
A:
[2-293]
---------
T
L
-
M
V
P
F
K
Q
V
D
V
F
T
E
K
P
F
M
G
N
P
V
A
V
I
N
----
F
L
EIDE
N
---
E
V
S
Q
---------------
E
E
L
-
Q
A
I
A
N
W
---
T
N
L
S
E
T
T
---
F
L
--
F
K
P
S
DK
K
-
Y
D
Y
K
L
R
I
F
T
P
R
-
S
E
L
P
F
A
G
H
P
T
I
G
S
C
K
A
F
L
E
F
T
K
N
T
T
A
T
S
L
V
Q
E
C
K
-
I
G
A
V
P
I
T
I
N
-
E
------
G
L
I
S
F
K
A
P
M
A
D
Y
--
E
-
S
--
I
-
S
S
E
M
--
I
A
D
Y
E
K
A
I
G
--
L
K
F
-----
I
K
P
P
A
L
L
H
T
G
P
E
W
I
V
-
A
L
V
E
D
----
A
E
T
--
C
F
N
A
N
P
N
F
A
M
L
A
H
Q
T
K
Q
N
--------
D
H
V
G
I
I
L
A
G
P
-
K
K
E
A
A
I
K
N
S
Y
E
M
R
A
-
F
A
--
P
V
-
I
-
N
V
Y
E
D
P
V
C
G
S
G
S
-
V
A
-
L
A
R
Y
L
Q
E
V
-
Y
---
K
F
E
---
K
T
T
D
-
I
T
-
I
S
----
E
G
G
R
L
K
-
R
N
-
G
L
M
L
A
S
I
K
-----
K
--
E
A
-
D
N
S
T
S
Y
Y
I
A
G
H
A
T
T
V
I
D
G
K
I
K
-----
44
Fugue
58.66
20%
-85
- C4 -
1YM5
-
YHI9_YEAST
A:
[2-295]
---------
T
L
-
M
V
P
F
K
Q
V
D
V
F
T
E
K
P
F
M
G
N
P
V
A
V
I
N
FLEI
D
E
----
N
---
E
V
S
Q
---------------
E
E
L
-
Q
A
I
A
N
W
---
T
N
L
S
E
T
T
---
F
L
F
K
P
S
D
K
--
K
-
Y
D
Y
K
L
R
I
F
T
P
R
-
S
E
L
P
F
A
G
H
P
T
I
G
S
C
K
A
F
L
E
F
T
K
N
T
T
A
T
S
L
V
Q
E
C
K
-
I
G
A
V
P
I
T
I
N
-
E
G
------
L
I
S
F
K
A
P
M
A
D
Y
--
E
-
S
--
I
S
S
E
-
M
--
I
A
D
Y
E
K
A
I
G
--
L
K
-----
F
I
K
P
P
A
L
L
H
T
G
P
E
W
I
V
-
A
L
V
E
D
----
A
E
T
--
C
F
N
A
N
P
N
F
A
M
L
A
H
Q
T
K
Q
N
--------
D
H
V
G
I
I
L
A
G
P
K
K
E
A
A
-
I
K
N
S
Y
E
M
R
A
-
F
A
--
P
V
-
I
-
N
V
Y
E
D
P
V
C
G
S
G
S
-
V
A
-
L
A
R
Y
L
Q
E
V
Y
K
---
F
E
K
---
T
-
T
D
-
I
T
-
I
S
----
E
G
G
R
L
K
-
R
N
-
G
L
M
L
A
S
I
K
K----
E
--
A
D
-
N
S
T
-
S
Y
Y
I
A
G
H
A
T
T
V
I
D
G
K
I
K
V
H---
59
HHSearch
57.27
27%
-91
- C4 -
1S7J
-
?
A:
[1-260]
----------
M
-
S
Y
P
Y
Y
I
V
D
A
F
A
E
E
V
F
K
G
N
P
A
A
V
Y
V
----
L
E
----
K
---
W
L
P
E
---------------
A
V
M
-
Q
N
I
A
I
E
---
N
N
L
S
E
T
A
---
F
T
--
V
K
E
---
G
-
Q
S
Y
A
L
R
W
F
T
P
E
-
R
E
I
D
L
C
G
H
A
T
L
A
T
A
F
V
L
F
N
Y
Y
S
V
A
E
-
E
T
L
H
F
T
S
Q
-
S
G
P
L
A
V
T
K
K
-
E
------
E
Y
Y
Y
L
D
F
P
Y
I
L
P
--
E
-
R
--
I
-
P
I
----
L
P
E
Y
E
A
A
L
G
--
T
---------
K
I
Y
E
A
Y
L
G
R
-
D
L
F
-
F
V
L
K
D
----
E
E
T
--
V
A
K
I
T
P
D
F
S
A
L
K
A
L
D
L
G
-----------
V
G
V
I
V
T
A
S
-
G
----
D
S
V
D
F
V
S
R
T
-
F
F
--
P
K
-
L
-
R
I
N
E
D
P
V
C
G
S
A
H
-
A
N
-
L
I
P
Y
W
G
K
R
-
L
---
N
Q
------
T
T
-
L
S
-
A
Y
----
Q
V
S
--
P
-
R
G
-
G
F
L
T
C
E
V
K
-----
E
--
N
------
R
V
I
I
G
G
T
A
K
L
F
A
K
G
E
A
Y
L
----
58
HHSearch
56.49
26%
-79
- C4 -
4DUN
4
?
A:
[3-261]
------------
A
M
E
Y
Y
I
V
D
S
F
A
T
K
L
F
K
G
N
P
A
G
V
C
V
----
L
D
----
R
---
R
I
P
L
---------------
E
L
M
-
Q
K
I
A
E
E
---
N
N
L
P
E
T
A
---
F
V
--
V
K
G
---
K
-
G
N
Y
E
L
R
W
F
T
P
K
-
A
E
I
D
L
C
G
H
A
T
L
A
A
A
Y
V
I
S
N
F
I
D
V
N
V
-
K
K
I
D
F
F
T
Q
-
S
G
K
L
E
V
T
R
N
-
G
------
N
L
Y
E
M
I
F
P
E
I
M
P
--
I
-
E
--
I
-
E
--
L
--
S
P
Q
Q
A
N
L
I
G
--
C
V
P
--------
S
D
V
--
Y
S
S
R
D
L
I
-
L
L
L
N
S
----
E
Q
E
--
V
I
N
Y
K
P
N
Y
A
Q
L
R
K
L
T
D
W
-----------
L
G
I
I
I
T
A
Q
-
G
S
----
N
T
D
F
V
S
R
Y
-
F
C
--
P
E
-
L
-
D
-
S
E
D
P
V
T
G
S
S
H
-
C
N
-
L
I
P
Y
W
S
E
K
-
L
---
G
-----
K
-
H
K
-
M
V
-
A
A
----
Q
L
S
--
N
-
R
G
-
G
I
I
Q
C
E
V
L
-----
K
--
D
N
-----
T
V
K
I
S
G
E
A
V
L
F
M
Q
G
T
I
K
I
----
12
PsiBlast_PDB
51.68
28%
-87
- C4 -
1S7J
-
?
A:
[9-214]
-------------------
D
A
F
A
E
E
V
F
K
G
N
P
A
A
V
Y
V
----
L
E
----
K
---
W
L
P
E
---------------
A
V
M
-
Q
N
I
A
I
E
---
N
N
L
S
E
T
A
---
F
T
--
V
K
-
E
--
G
-
Q
S
Y
A
L
R
W
F
T
P
E
-
R
E
I
D
L
C
G
H
A
T
L
A
T
A
F
V
L
F
N
Y
Y
S
V
-
A
E
E
T
L
H
F
T
S
Q
-
S
G
--
P
L
A
V
T
-
K
K
E
-
E
Y
-
Y
Y
L
D
F
P
Y
I
L
P
E
R
--
I
-
P
--
I
-
L
P
-
E
--
Y
E
A
---
A
L
G
TK
I
Y
E
A
Y
L
G
R
D
L
F
F
V
-------------
L
K
D
----
E
E
T
--
V
A
K
I
T
P
D
F
S
A
L
K
A
--
L
D
L
--------
G
V
G
V
I
V
T
A
S
G
-
D
S
V
-----
D
F
V
S
R
T
-
F
-
F
-
P
K
-
L
-
R
I
N
E
D
P
V
C
G
S
A
H
-
A
N
-
L
I
P
Y
W
-----------------------------------------------------------------------------------
13
PsiBlast_PDB
50.19
21%
-79
- C4 -
1U0K
-
?
A:
[62-274]
-------------------------------------------------------------------------------------------------------------
R
I
F
T
L
E
-
E
E
L
P
F
A
G
H
P
L
L
G
A
A
A
L
L
H
H
L
R
G
G
D
N
E
Q
H
W
T
L
H
L
A
-
S
K
S
V
A
L
R
S
V
-
R
A
G
-
S
G
-
F
Y
A
E
M
D
Q
G
R
A
E
F
G
A
T
-
P
--
D
-
A
G
-
T
--
C
R
W
F
A
E
A
F
S
--
L
S
A
N
D
L
S
G
H
P
P
R
V
V
-
S
T
G
L
P
Y
L
L
-
L
P
V
T
A
----
E
A
L
--
G
R
A
R
Q
V
N
D
L
Q
--
E
A
L
D
K
L
--------
G
A
A
F
V
Y
L
L
-----------
D
V
D
G
R
E
-
G
R
T
-
W
D
-
N
L
G
L
V
E
D
V
A
T
G
S
A
A
-
G
P
-
V
A
A
Y
L
V
E
Y
-
G
---
L
A
A
---
R
-
G
E
P
F
V
-
L
H
----
Q
G
R
F
L
E
-
R
P
-
S
R
L
D
V
Q
V
A
TDG
S
V
R
--
V
G
-
G
H
V
-
Q
L
--------------------
62
HHSearch
48.24
18%
-83
- C4 -
2GKE
5
DAPF_HAEIN
A:
[2-274]
--------------------
Q
F
S
K
M
H
G
L
G
N
D
F
V
V
V
D
----
G
V
----
T
QN
V
F
F
T
P
---------------
E
T
I
-
R
R
L
A
N
R
HCG
I
G
F
D
Q
L
L
---
I
V
--
E
A
P
Y
DP
E
-
L
D
F
H
Y
R
I
F
N
A
D
G
S
E
V
S
Q
C
G
N
G
A
R
C
F
A
R
F
V
T
L
K
G
L
T
N
K
-
K
D
I
S
V
S
T
Q
-
K
G
N
M
V
L
T
V
K
-
D
D
-----
N
Q
I
R
V
N
M
G
E
P
I
W
--
E
-
P
--
A
-
K
I
-
P
FT
A
N
K
F
E
K
N
Y
I
--
L
R
-
T
D
I
-
Q
T
V
L
C
G
A
V
S
M
G
N
P
H
C
V
-
V
Q
V
D
D
----
I
Q
T
AN
V
E
Q
L
G
P
L
L
E
S
H
E
R
F
P
E
R
V
--------
N
A
--
G
F
M
Q
I
I
-
N
-----
K
E
H
I
K
L
R
V
-
Y
E
--
R
----
G
A
G
E
T
Q
A
C
G
S
G
A
-
C
A
-
A
V
A
V
G
I
M
Q
-
G
---
L
L
N
-----
N
N
-
V
Q
-
V
D
----
L
------
P
G
-
G
S
L
M
I
E
W
N
-----
G
--
V
G
-
H
---
P
L
Y
M
T
G
E
A
T
H
I
Y
D
G
F
I
T
L
----
69
HHSearch
47.59
18%
-65
- C4 -
4JUU
5
4HYPE_XANCP
A:
[27-322]
--------------------
D
V
I
D
S
H
T
A
G
E
P
T
R
V
V
L
----
A
G
F---
P
---
D
L
G
D
GD
L
A
Q
C
R
E
R
F
R
S
DF
D
H
W
R
-
S
A
I
A
C
E
---
P
R
G
S
D
T
M
V
G
A
L
L
--
L
P
P
R
DP
S
-
A
C
T
G
V
I
F
F
N
N
V
-
G
Y
L
G
M
C
G
H
G
T
I
G
V
V
R
T
L
A
E
L
G
R
I
A
P
-
G
Q
H
R
I
E
T
P
-
V
G
T
V
G
V
A
L
A
-
D
D
-----
G
T
V
S
I
D
N
V
-
E
S
Y
--
R
-
H
--
A
-
A
--
G
--
V
E
V
--
D
-----
V
P
G
--
H
-
G
R
V
R
G
D
V
A
W
G
G
N
W
F
F
I
-
T
E
Q
A
P
CALG
L
A
Q
--
Q
R
E
L
T
A
Y
T
E
A
I
R
L
A
L
E
A
A
GITGEAGG
E
I
D
H
I
E
I
S
G
V
-
A
----
P
D
G
S
G
A
A
R
N
-
F
V
L
C
P
--
G
-
L
A
Y
D
R
S
P
C
G
T
G
T
S
A
K
-
L
A
C
L
A
A
D
--
G
---
K
L
A
---
E
-
G
E
-
R
W
-
L
Q
----
Q
G
I
L
----
G
-
S
A
F
E
G
S
Y
R
-----
H
--
S
--
G
R
G
I
A
P
R
I
S
G
H
A
F
I
T
A
R
S
Q
L
L
I
----