@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu09480: (2016-06-14 )
MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRLSSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQKNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFVRLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVTPICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIEDDYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNVQLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILGKNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEEDIRLGIQKLKTAWAPLISSY
Atome Classification :
(20 SA)
........-.10...-.....20........30........40........50........60........70......-------..80.--.......90....-....100.......110.......120.......130.......140...---.-...150.......160.......170.......180.....-.-.190.......200.......210.......220....----...230.---.---------.....240.......250.......260.......-270.......280.......290....---...300-.........310.......320.......330........340.......350.......-360........370.......380.......390.......400.......410.....-.----.420.....----..430----.......440.......450.......460.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDITPFLD-KKSKT
P
-
L
Y
E
Q
L
Y
T
F
F
K
Q
EI
S
H
ARITKGTRL
P
S
K
R
R
L
S
S
L
L
D
V
S
T
A
T
I
E
R
A
Y
E
Q
L
T
AEGYVKSKPK
I
G
W
F
-------
A
AEVE--PGFPTA
P
D
H
F
Q
Q
S
-VQPGLHQKNAP
A
I
D
FHQGSVDPTLF
P
F
N
A
W
R
K
S
I
V
K
S
L
D
R
YSGSFHTSGD---P-Q
G
E
Y
E
L
R
H
M
I
A
R
F
V
R
L
SRGVNCEPG
Q
I
I
IGA
G
T
T
V
L
L
Q
N
L
C
-L-SLKPGTKIGFEEPG
F
H
R
S
R
RMFEANHMDVTPICSDAEG----VL
P
D
E
L
Y---R---------QN
P
Y
L
M
Y
TTPSHQFPI
G
T
I
M
T
I
T
R
R
Q
E
L
L
A
W
AAET-N
S
F
I
I
EDDYDG
E
F
RYSGHPIPSLQGLD---PN
G
R
---
V
I
Y
L
GT
F
S
K
S
L
L
P
S
L
R
L
S
F
M
IV
P
P
E
L
M
E
P
I
-
Q
N
N
V
Q
L
M
K
Q
T
V
S
A
H
S
Q
L
A
L
A
D
F
I
ET
G
E
W
Q
-
K
-
H
I
N
R
M
R
S
L
Y
R
K
K
H
A
V
L
L
E
A
I
R
S
ELG
N
T
V
E
I
LGKNS
G
L
H
I
L
L
R
L
LFPA
S
E
E
E
A
I
Q
A
AA-D----H
G
V
T
L
Y
PV
S
----
P
S
Y
IE----QTPF
T
S
V
L
I
GYGGL
S
E
E
D
I
R
L
G
I
Q
K
L
K
T
A
W
A
P
L
ISSY
24
PsiBlast_CBE
75.00
39%
-105
- C3 -
4N0B
2
GABR_BACSU
D:
[2-467]
-
D
I
T
I
T
L
D
-
R
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
VEELDMF
S
A
E
E
H
--
P
P
F
-
A
L
P
D
D
L
K
E
------
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
---
S
Y
R
T
L
G
D
MSH
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
K
Q
R
G
Y
D
L
--
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
----
R
F
N
L
K
EN----
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
--------
2
PsiBlast_PDB
74.86
39%
-104
- C3 -
4N0B
2
GABR_BACSU
A:
[3-467]
--
I
T
I
T
L
D
-
R
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
ELDMF
S
A
E
E
H
--
P
P
F
-
A
L
P
D
D
L
K
E
------
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
---
S
Y
R
T
L
G
D
MSH
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
K
Q
R
G
Y
D
L
--
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
----
R
F
N
L
K
E----
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
--------
22
PsiBlast_CBE
74.24
39%
-107
- C3 -
4MGR
5
GABR_BACSU
C:
[1-467]
M
D
I
T
I
T
L
D
-
R
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
E
L
D
M
F
S
A
E
E
H
--
P
P
F
-
A
L
P
D
D
L
K
E
------
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
---
S
Y
R
T
L
G
D
MSH
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
-
K
Q
R
G
Y
D
L
-
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
----
R
F
N
L
K
ENKR
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
--------
21
PsiBlast_CBE
74.05
39%
-111
- C3 -
4MGR
4
GABR_BACSU
D:
[1-467]
M
D
I
T
I
T
L
D
-
R
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
VEELDMF
S
A
E
E
H
--
P
P
F
-
A
L
P
D
D
L
K
E
------
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
---
S
Y
R
T
L
G
D
MSH
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
-
K
Q
R
G
Y
D
L
-
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
----
R
F
N
L
K
ENKR
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
--------
25
PsiBlast_CBE
73.93
39%
-102
- C3 -
4N0B
1
GABR_BACSU
C:
[3-467]
--
I
T
I
T
L
D
-
R
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
VEELDMF
S
A
E
E
H
--
P
P
F
-
A
L
P
D
D
L
K
E
------
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
---
S
Y
R
T
L
G
D
MSH
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
K
Q
R
G
Y
D
L
--
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
----
R
F
N
L
K
E----
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
--------
26
PsiBlast_CBE
73.71
39%
-106
- C3 -
4N0B
2
GABR_BACSU
B:
[3-467]
--
I
T
I
T
L
D
-
R
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
ELDMF
S
A
E
E
H
--
P
P
F
-
A
L
P
D
D
L
K
E
------
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
---
S
Y
R
T
L
G
D
MSH
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
K
Q
R
G
Y
D
L
--
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
----
R
F
N
L
K
EN----
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
--------
1
PsiBlast_PDB
72.99
39%
-107
- C3 -
4MGR
3
GABR_BACSU
A:
[2-467]
-
D
I
T
I
T
L
D
-
R
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
ELDMF
S
A
E
E
H
--
P
P
F
-
A
L
P
D
D
L
K
E
------
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
---
S
Y
R
T
L
G
D
MSH
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
-
K
Q
R
G
Y
D
L
-
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
----
R
F
N
L
K
ENKR
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
--------
29
Fugue
72.65
39%
-104
- C3 -
4MGR
3
GABR_BACSU
A:
[2-469]
-
D
I
T
I
T
L
D
-
R
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
-------
V
E
E
L
D
MF
S
A
E
E
H
P
P
F
A
L
P
D
D
-
L
K
E
-
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
D
M
S
H
---
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
-
K
Q
R
-
G
Y
D
L
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
RFNL
K
E
N
K
R
----
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
------
V
Y
23
PsiBlast_CBE
71.22
39%
-106
- C3 -
4MGR
6
GABR_BACSU
B:
[2-467]
-
D
I
T
I
T
L
D
-
R
S
E
Q
A
D
Y
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
ELDMF
S
A
-----------
P
D
D
L
K
E
------
I
H
I
D
Q
S
D
W
I
S
F
S
H
M
S
S
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
---
S
Y
R
T
L
G
D
MSH
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
-
K
Q
R
G
Y
D
L
-
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
----
R
F
N
L
K
ENKR
Q
T
G
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
L
F
K
A
--------
39
HHSearch
69.81
38%
-104
- C3 -
4TV7
-
GABR_BACSU
A:
[4-463]
---
T
I
T
L
D
R
S
E
Q
A
D
Y
-
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
-------
V
E
E
L
D
--
M
F
S
A
------
A
L
P
D
D
L
K
E
I
H
I
----
W
I
S
F
S
H
M
--
D
T
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
-----
M
S
H
---
P
-
Q
G
I
Y
E
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
-
E
-
L
L
P
K
E
A
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
----
M
S
I
A
E
I
T
---
R
---------
Q
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
L
Q
S
L
D
---
R
F
Q
N
---
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
-
K
Q
R
-
G
Y
D
L
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
-
K
-
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
-
D
T
R
R
T
E
Q
D
I
L
S
H
A
A
-
G
----
L
Q
L
E
I
F
G
M
S
----
R
F
----------
R
P
A
L
I
I
G
F
A
R
L
K
E
E
D
I
Q
E
G
V
Q
R
------------
52
HHSearch
55.40
24%
-110
- C3 -
2ZYJ
2
LYSN_THET2
A:
[31-395]
-------------------------------------------------------------------------------------------------------------------
R
P
G
I
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
L
R
E
K
G
E
V
A
L
Q
Y
S
P
---
T
-
E
G
Y
A
P
L
R
A
F
V
A
E
W
I
----
G
--
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
-
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
----
P
D
L
D
A
L
E
E
V
L
K
R
--------
E
R
P
R
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
-
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
R
E
A
G
Y
P
G
---
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
-
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
-
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
----
E
N
V
A
F
V
P
G
G
----
P
F
F
A
N
----
G
G
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
L
A
--
15
PsiBlast_PDB
53.62
24%
-117
- C3 -
2ZYJ
2
LYSN_THET2
A:
[35-395]
-----------------------------------------------------------------------------------------------------------------------
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
L
-
R
E
K
G
E
V
A
L
Q
Y
S
---
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
I
------
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
-
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
PD
L
D
A
L
E
E
V
L
K
---
R
---------
E
R
P
R
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
-
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
---
R
E
A
G
YPG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
-
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
-
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
----
E
N
V
A
F
V
P
G
G
----
P
F
F
A
N
----
G
G
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
L
A
--
13
PsiBlast_PDB
52.76
24%
-115
- C3 -
3CBF
2
LYSN_THET2
A:
[35-395]
-----------------------------------------------------------------------------------------------------------------------
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
L
-
R
E
K
G
E
V
A
L
Q
Y
S
---
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
I
------
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
-
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
PD
L
D
A
L
E
E
V
L
K
---
R
---------
E
R
P
R
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
-
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
---
R
E
A
G
YPG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
-
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
-
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
----
E
N
V
A
F
V
P
G
G
----
P
F
F
A
N
----
G
G
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
L
A
--
11
PsiBlast_PDB
52.55
24%
-107
- C3 -
2EGY
2
LYSN_THET2
A:
[35-395]
-----------------------------------------------------------------------------------------------------------------------
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
L
-
R
E
K
G
E
V
A
L
Q
Y
S
---
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
I
------
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
-
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
PD
L
D
A
L
E
E
V
L
K
---
R
---------
E
R
P
R
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
-
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
---
R
E
A
G
YPG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
-
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
-
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
----
E
N
V
A
F
V
P
G
G
----
P
F
F
A
N
----
G
G
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
L
A
--
48
HHSearch
52.10
26%
-108
- C3 -
2ZC0
4
?
A:
[33-405]
-------------------------------------------------------------------------------------------------------------------
G
V
K
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
L
E
K
E
-
P
K
S
V
M
Y
T
P
---
A
-
N
G
I
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
H
L
E
V
S
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
-
R
V
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
----
M
R
V
D
L
L
E
E
K
I
K
E
L
K
A
K
G---
Q
K
V
K
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
Y
-
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
I
V
P
L
K
A
L
D
---
N
E
G
R
---
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
-
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
F
E
K
Y
-
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
-
N
A
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
A
D
G
I
S
F
A
N
E
L
M
E
R
----
E
G
V
V
V
V
P
G
K
----
P
F
Y
T
D
----
E
S
G
K
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
P
I
G
I
K
K
L
A
K
L
Y
K
E
K
F
---
10
PsiBlast_PDB
51.77
26%
-106
- C3 -
2ZC0
4
?
A:
[29-401]
---------------------------------------------------------------------------------------------------------------
L
Q
K
K
G
V
K
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
L
E
K
E
P
K
S
V
M
Y
T
-
P
---
A
-
N
G
I
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
H
L
E
V
S
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
-
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
----
M
R
V
D
L
L
E
---
E
K
I
K
E
L
K
A
K
G
Q
K
V
K
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
Y
-
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
I
V
P
L
K
A
L
D
---
N
E
G
R
---
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
-
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
G
Y
F
E
-
K
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
N
A
-
E
F
T
K
P
I
A
G
M
F
V
---
M
F
F
L
P
E
G
A
D
G
I
S
F
A
N
-
E
L
M
E
R
E
G
V
V
V
V
P
G
K
----
P
F
Y
T
D
----
E
S
G
K
N
A
I
R
L
N
F
S
R
P
S
K
E
E
I
P
I
G
I
K
K
L
A
K
L
Y
-------
14
PsiBlast_PDB
51.73
24%
-113
- C3 -
2Z1Y
2
LYSN_THET2
A:
[35-395]
-----------------------------------------------------------------------------------------------------------------------
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
L
-
R
E
K
G
E
V
A
L
Q
Y
S
---
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
I
------
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
-
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
PD
L
D
A
L
E
E
V
L
K
---
R
---------
E
R
P
R
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
-
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
---
R
E
A
G
YPG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
-
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
-
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
----
E
N
V
A
F
V
P
G
G
----
P
F
F
A
N
----
G
G
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
L
A
--
12
PsiBlast_PDB
51.73
24%
-119
- C3 -
2ZP7
3
LYSN_THET2
C:
[35-395]
-----------------------------------------------------------------------------------------------------------------------
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
A
A
A
R
I
L
-
R
E
K
G
E
V
A
L
Q
Y
S
---
P
T
E
G
Y
A
P
L
R
A
F
V
A
E
W
I
------
G
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
-
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
PDLD
A
L
E
E
V
L
K
---
R
---------
E
R
P
R
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
R
-
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
E
L
A
---
R
E
A
G
YPG
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
-
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
G
-
F
S
-
E
-
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
L
-
E
----
E
N
V
A
F
V
P
G
G
----
P
F
F
A
N
----
G
G
G
E
N
T
L
R
L
S
Y
A
T
L
D
R
E
G
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
L
A
--
7
PsiBlast_PDB
51.34
26%
-103
- C3 -
3AV7
5
?
A:
[79-438]
-----------------------------------------------------------------------------------------------------------------------
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
M
E
K
Y
A
D
K
A
L
Q
Y
G
T
---
T
-
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
MK
V
E
I
L
E
E
K
L
K
---
E
L
K
S
Q
G----
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
-
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
---
N
E
G
R
---
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
-
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
----
K
G
V
A
Y
V
P
G
E
----
A
F
Y
A
H
----
R
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
-----------
4
PsiBlast_PDB
51.24
26%
-101
- C3 -
3AOV
2
?
A:
[79-438]
-----------------------------------------------------------------------------------------------------------------------
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
I
L
V
E
I
M
E
K
Y
A
D
K
A
L
Q
Y
G
T
---
T
-
K
G
F
T
P
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
S
-
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
-
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
MK
V
E
I
L
E
E
K
L
K
---
E
L
K
S
Q
G----
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
Y
-
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
E
K
K
I
K
A
L
D
---
N
E
G
R
---
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
-
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
L
E
-
K
-
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
I
-
K
----
K
G
V
A
Y
V
P
G
E
----
A
F
Y
A
H
----
R
D
V
K
N
T
M
R
L
N
F
T
Y
V
D
E
D
K
I
M
E
G
I
K
R
L
-----------