@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu09620: (2016-06-15 )
MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQIVVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKIGLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVITRPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKLQAMGVDGIVTDYPDFIIKDGKHENI
Atome Classification :
(22 SA)
.........10........20....-....30........40........50........60........70........80-------.--------...--------.....90.........100....-....-110-.......120---.........130-----..-..-------.....140.......150...------------------....160....-.-.-.170-----------....-...180--..--..------..----.190.......200.......210.......220.......230---.......240.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
I
I
A
HRGASGYAPEN
T
I
A
A
F
D
L
A
V
-
K
MNA
D
M
I
E
L
D
V
Q
LTKD
R
Q
I
V
V
I
HDDRVDRTTNGSG
F
V
KDF
T
L
E
E
L
Q
KLDAGSWYG--------P--------AFQ--------GERI
P
T
-
L
E
A
V
L
K
R
Y
H
K
-KI
G
L
L
-
I
E
LK-GHP-SQVG
I
E
E
E
-----
V
G
Q
L
L
G
Q
F
S
F
-------
S
I
-
N
N
-------
I
V
Q
S
F
Q
F
R
S
V
Q
R
F
R
E
LYPSIP------------------
T
A
V
ITRPNFGM-L-
S
-
R
N
Q
M
-----------
K
A
F
R
-
S
F
A
N
Y
V
--
N
I
--
K
H
------
T
R
----L
N
R
L
M
I
GSINKN
G
L
N
I
F
A
W
T
VNNQ
K
T
A
A
K
L
Q
AMGVDGIVTDYP
D
---
F
IIKDGKHENI
1
PsiBlast_PDB
76.83
42%
-103
- C4 -
2PZ0
2
?
A:
[14-245]
--
V
I
A
H
R
G
D
S
K
N
V
P
E
N
T
I
A
A
F
K
R
A
M
-
E
L
G
A
D
G
I
E
L
D
V
Q
L
T
K
D
G
H
L
V
V
I
H
D
E
T
V
D
R
T
T
N
G
E
G
F
V
K
D
F
T
L
E
E
I
K
K
L
D
A
G
I
K
F
G
--------
E
--------
K
F
A
--------
G
E
R
I
P
T
-
L
Y
E
V
F
E
L
I
G
D
-
K
D
F
L
V
N
I
E
I
K
S
G
I
V
-
L
Y
P
G
I
E
E
K
-----
L
I
K
A
I
K
E
Y
N
F
-------
E
E
-
R
V
-------
I
I
S
S
F
N
H
Y
S
L
R
D
V
K
K
M
A
P
H
L
K
------------------
I
G
L
L
Y
Q
--
C
G
L
-
V
-
E
-
P
W
H
M
------------
A
L
R
-
M
E
A
Y
S
L
--
H
P
--
F
Y
------
F
N
----
I
I
P
E
L
V
E
G
C
K
K
N
G
V
K
L
F
P
W
T
V
D
R
K
E
D
M
E
R
M
I
K
A
G
V
D
G
I
I
T
D
D
P
E
---
T
L
I
--------
21
PsiBlast_CBE
76.78
42%
-105
- C4 -
2PZ0
2
?
B:
[14-245]
--
V
I
A
H
R
G
D
S
K
N
V
P
E
N
T
I
A
A
F
K
R
A
M
-
E
L
G
A
D
G
I
E
L
D
V
Q
L
T
K
D
G
H
L
V
V
I
H
D
E
T
V
D
R
T
T
N
G
E
G
F
V
K
D
F
T
L
E
E
I
K
K
L
D
A
G
I
K
F
G
--------
E
--------
K
F
A
--------
G
E
R
I
P
T
-
L
Y
E
V
F
E
L
I
G
D
-
K
D
F
L
V
N
I
E
I
K
S
G
I
V
-
L
Y
P
G
I
E
E
K
-----
L
I
K
A
I
K
E
Y
N
F
-------
E
E
-
R
V
-------
I
I
S
S
F
N
H
Y
S
L
R
D
V
K
K
M
A
P
H
L
K
------------------
I
G
L
L
Y
Q
--
C
G
L
-
V
-
E
-
P
W
H
M
------------
A
L
R
-
M
E
A
Y
S
L
--
H
P
--
F
Y
------
F
N
----
I
I
P
E
L
V
E
G
C
K
K
N
G
V
K
L
F
P
W
T
V
D
R
K
E
D
M
E
R
M
I
K
A
G
V
D
G
I
I
T
D
D
P
E
---
T
L
I
--------
66
HHSearch
74.84
39%
-104
- C4 -
2PZ0
2
?
A:
[12-249]
T
L
V
I
A
H
R
G
D
S
K
N
V
P
E
N
T
I
A
A
F
K
R
A
M
-
E
L
G
A
D
G
I
E
L
D
V
Q
L
T
K
D
G
H
L
V
V
I
H
D
E
T
V
D
R
T
T
N
G
E
G
F
V
K
D
F
T
L
E
E
I
K
K
L
D
A
G
I
K
F
G
--------
E
--------
K
F
A
--------
G
E
R
I
P
T
-
L
Y
E
V
F
E
L
I
G
D
K
D
F
L
V
N
-
I
E
I
K
-
S
G
I
V
L
Y
P
G
I
E
E
K
-----
L
I
K
A
I
K
E
Y
N
F
-------
E
E
-
R
V
-------
I
I
S
S
F
N
H
Y
S
L
R
D
V
K
K
M
A
P
H
L
K
------------------
I
G
L
L
Y
Q
C
G
L
V
E
--------
P
-----------
W
H
M
A
-
L
R
M
E
A
Y
--
S
L
H
P
F
Y
------
F
N
----
I
I
P
E
L
V
E
G
C
K
K
N
G
V
K
L
F
P
W
T
V
D
R
K
E
D
M
E
R
M
I
K
A
G
V
D
G
I
I
T
D
D
P
E
---
T
L
I
N
L
V
R
----
67
HHSearch
72.59
37%
-98
- C4 -
4R7O
7
?
A:
[16-291]
F
L
N
I
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
--------
K
A
Y
PEKAKQ
E
Y
V
--------
G
Q
K
V
P
T
-
L
E
E
I
F
Q
K
Y
G
R
-
S
M
K
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
K
-----
L
L
A
L
L
E
K
Y
N
L
IGQNMS-
S
S
-
R
V
-------
M
I
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
P
------------------
L
V
Q
L
L
W
Y
Y
P
N
E
-
N
N
E
I
V
E
W
S
GITHEPKRVT
N
D
D
F
Q
E
I
K
K
Y
A
V
--
G
I
G
P
N
L
RNDNGD
L
I
----
I
N
E
S
Y
M
K
M
A
R
Q
N
G
L
L
I
H
P
Y
T
I
N
E
K
P
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
---
R
L
H
T
V
L
K
E
---
35
PsiBlast_CBE
72.59
33%
-88
- C4 -
2OOG
7
?
F:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
KKYPKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
KLKNGHV
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
KYK
E
V
I
K
E
------
39
PsiBlast_CBE
72.15
33%
-84
- C4 -
2OOG
4
?
B:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
KKYPKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
KLKNGHV
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
KYK
E
V
I
K
E
------
22
PsiBlast_CBE
71.92
32%
-102
- C4 -
4R7O
7
?
G:
[19-283]
---
I
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
--------
K
--------
A
Y
P
EKAKQEYV
G
Q
K
V
P
T
-
L
E
E
I
F
Q
K
Y
G
R
-
S
M
K
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
K
-----
L
L
A
L
L
E
K
Y
N
L
-------
I
----RV-----
M
I
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
P
LVQLLWYYPNENNEIVEW
S
G
I
T
H
E
P
K
--
R
-
V
-
T
-
N
D
D
F
-----------
Q
E
I
K
-
K
Y
A
V
G
I
GP
N
L
--
R
N
------
D
N
GDLI
I
N
E
S
Y
M
K
M
A
R
Q
N
G
L
L
I
H
P
Y
T
I
N
E
K
P
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
--------------
23
PsiBlast_CBE
71.84
32%
-99
- C4 -
4R7O
2
?
F:
[19-283]
---
I
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
--------
K
--------
A
Y
P
EKAKQEYV
G
Q
K
V
P
T
-
L
E
E
I
F
Q
K
Y
G
R
-
S
M
K
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
K
-----
L
L
A
L
L
E
K
Y
N
L
-------
I
----RV-----
M
I
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
P
LVQLLWYYPNENNEIVEW
S
G
I
T
H
E
P
K
--
R
-
V
-
T
-
N
D
D
F
-----------
Q
E
I
K
-
K
Y
A
V
G
I
GP
N
L
--
R
N
------
D
N
GDLI
I
N
E
S
Y
M
K
M
A
R
Q
N
G
L
L
I
H
P
Y
T
I
N
E
K
P
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
--------------
24
PsiBlast_CBE
71.52
32%
-100
- C4 -
4R7O
2
?
E:
[19-283]
---
I
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
--------
K
--------
A
Y
P
EKAKQEYV
G
Q
K
V
P
T
-
L
E
E
I
F
Q
K
Y
G
R
-
S
M
K
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
K
-----
L
L
A
L
L
E
K
Y
N
L
-------
I
G
---
S
R
V
----
M
I
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
P
L
V
Q
L
L
W
Y
Y
PNE
N
N
E
I
VEW
S
G
I
T
H
E
P
K
--
R
-
V
-
T
-
N
D
D
F
-----------
Q
E
I
K
-
K
Y
A
V
G
I
G
P
N
L
--
R
N
------
D
N
GDLI
I
N
E
S
Y
M
K
M
A
R
Q
N
G
L
L
I
H
P
Y
T
I
N
E
K
P
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
--------------
3
PsiBlast_PDB
71.52
33%
-88
- C4 -
2OOG
10
?
A:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
K
K
Y
PKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
K
L
K
N
GH
V
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L
-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
K
Y
K
E
V
I
K
E
------
71
HHSearch
71.08
33%
-87
- C4 -
2OOG
10
?
A:
[24-279]
F
T
T
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
--------
K
K
Y
PKYARA
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
LN
N
N
K
L
K
N
G
-
H
V
-------
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
------------------
L
V
K
L
V
D
K
G
E
L
Q
Q
F
-
N
-
D
Q
R
L
-----------
K
E
I
---
R
S
Y
A
I
--
G
L
G
P
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
---
K
Y
K
E
V
I
K
----
6
PsiBlast_PDB
71.08
34%
-90
- C4 -
3QVQ
14
?
A:
[12-243]
--
V
I
A
H
R
G
S
S
G
Q
A
P
E
N
T
L
A
S
L
H
L
A
G
-
Q
Q
G
I
K
W
V
E
I
D
V
M
L
S
G
D
G
I
P
V
I
F
H
D
D
Y
L
S
R
T
T
D
G
D
G
L
I
Y
K
T
P
L
A
E
L
K
Q
L
D
A
G
S
W
K
G
--------
Q
--------
E
Y
Q
--------
Q
E
T
I
P
T
L
L
E
A
I
E
V
I
S
Q
Y
-
G
M
G
L
N
-
L
E
L
K
---
P
-
C
E
-
G
L
E
E
E
T
I
A
A
S
V
E
V
L
K
Q
H
W
P
Q
-------
D
L
-
P
L
-------
L
F
S
S
F
N
Y
F
A
L
V
S
A
K
A
L
W
P
E
I
A
------------------
R
G
Y
N
V
S
---
A
I
-
P
-
S
-
A
W
Q
E
-----------
R
L
E
H
-
L
D
C
A
G
L
--
H
I
--
H
Q
------
S
F
----
F
D
V
Q
Q
V
S
D
I
K
A
A
G
Y
K
V
L
A
F
T
I
N
D
E
S
L
A
L
K
L
Y
N
Q
G
L
D
A
V
F
S
D
Y
P
Q
---
K
I
---------
37
PsiBlast_CBE
70.89
33%
-87
- C4 -
2OOG
2
?
D:
[27-281]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
KKYPKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
KLKNGHV
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
KYK
E
V
I
K
E
G
-----
32
PsiBlast_CBE
70.77
33%
-83
- C4 -
2P76
2
?
D:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
KKYPKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
KLKNGHV
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
KYK
E
V
I
K
E
------
4
PsiBlast_PDB
70.67
33%
-82
- C4 -
2P76
2
?
A:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
K
K
Y
PKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
K
L
K
N
GH
V
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L
-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
K
Y
K
E
V
I
K
E
------
30
PsiBlast_CBE
70.61
33%
-83
- C4 -
2P76
2
?
F:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
KKYPKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
KLKNGHV
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
KYK
E
V
I
K
E
------
36
PsiBlast_CBE
70.60
33%
-84
- C4 -
2OOG
1
?
E:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
KKYPKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
KLKNGHV
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
KYK
E
V
I
K
E
------
28
PsiBlast_CBE
70.54
33%
-83
- C4 -
2P76
2
?
H:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
KKYPKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
KLKNGHV
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
KYK
E
V
I
K
E
------
31
PsiBlast_CBE
70.34
33%
-82
- C4 -
2P76
2
?
E:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
KKYPKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
KLKNGHV
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
KYK
E
V
I
K
E
------
29
PsiBlast_CBE
70.17
33%
-82
- C4 -
2P76
2
?
G:
[27-280]
---
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
KKYPKYAR
A
--------
S
Y
K
--------
N
A
K
V
P
T
-
L
D
E
I
L
E
R
Y
G
P
-
N
A
N
Y
Y
-
I
E
T
K
-
S
P
D
-
V
Y
P
G
M
E
E
Q
-----
L
L
A
S
L
K
K
H
H
L
-------
L
N
-
N
N
KLKNGHV
M
I
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
P
L-----------------
V
K
L
V
D
K
G
E
L
Q
Q
-
F
-
N
-
D
Q
R
L
-----------
K
E
I
R
-
S
Y
A
I
G
L
--
G
P
--
D
Y
------
T
D
----
L
T
E
Q
N
T
H
H
L
K
D
L
G
F
I
V
H
P
Y
T
V
N
E
K
A
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
KYK
E
V
I
K
E
------
62
HHSearch
64.58
30%
-92
* C4 *
3QVQ
15
?
A:
[10-250]
P
Q
V
I
A
H
R
G
S
S
G
Q
A
P
E
N
T
L
A
S
L
H
L
A
G
-
Q
Q
G
I
K
W
V
E
I
D
V
M
L
S
G
D
G
I
P
V
I
F
H
D
D
Y
L
S
R
T
T
D
G
D
G
L
I
Y
K
T
P
L
A
E
L
K
Q
L
D
A
G
S
W
K
G
--------
Q
--------
E
Y
Q
--------
Q
E
T
I
P
T
-
L
L
E
A
I
E
V
I
S
Q
Y
G
M
G
L
N
-
L
E
L
K
-
P
C
E
G
L
E
E
E
T
I
A
A
-----
S
V
E
V
L
K
Q
H
W
P
-------
Q
D
L
P
L
-------
L
F
S
S
F
N
Y
F
A
L
V
S
A
K
A
L
W
P
E
I
A
------------------
R
G
Y
N
V
S
A
I
P
S
A
--------
W
-----------
Q
E
R
L
-
E
H
L
D
C
A
--
G
L
H
I
H
Q
------
S
F
----
F
D
V
Q
Q
V
S
D
I
K
A
A
G
Y
K
V
L
A
F
T
I
N
D
E
S
L
A
L
K
L
Y
N
Q
G
L
D
A
V
F
S
D
Y
P
Q
---
K
I
Q
S
A
I
D
S
H
--
10
PsiBlast_PDB
21.22
45%
-38
- C4 -
3I10
8
?
A:
[20-87]
--
V
V
A
H
R
G
N
W
R
S
A
P
E
N
S
T
A
A
I
D
S
A
I
-
A
M
K
V
D
I
V
E
I
D
I
Q
K
T
K
D
G
Q
L
I
L
M
H
D
N
T
L
D
R
T
T
T
G
K
G
E
I
K
N
W
T
L
A
D
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------