@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu09840: (2016-06-15 )
MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISLALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTGITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAAVPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEWLKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITEEKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLIIGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMMEDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCGAASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH
Atome Classification :
(20 SA)
.........10........20........30........40........50..-......60........70........80........90........100.......--.110.......120.......130.---..-...-.140.......150.......160.....--.--.170......-.-180.......190.....-..200.......210-.....-..220.-----------......230...--.--...-.-240---.---........250.......260....-..----.----270...-....280...---.--...290.......-300...-.-------.---..310----.......--..320--...--...-..330-..-.......-340..-.....---350--.....------.--...---360..---------....-----------------.370.---...---.-..380.-......390-........------.400.--....---..410.......420.......----------430-..----------------......-440...---....450---......-...460....--...470.......480----........490.......500------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Q
I
K
I
EGIH
D
D
R
L
H
R
P
L
Q
N
I
A
N
L
F
Y
E
E
C
E
LAYGGEE
P
A
D
F
V
I
S
L
A
LSQTD
E
H
V
-
T
V
S
G
E
VKGTGI
K
E
Q
H
TKFFSPDM
T
E
K
E
A
F
K
Q
V
K
N
T
I
S
Y
V
Y
L
N
L
L
Q
A
H-TGIT
Q
K
WG--ILTGI
R
P
T
K
L
L
H
K
K
L
Q
SGM
S
K
E
Q
A
H
---
A
E
-
L
K
K
-
D
YLIH
D
E
K
I
M
L
M
Q
E
I
V
D
R
Q
L
A
AVP
D
L
Y
RV--K--D
E
V
S
I
Y
I
GIP-F-CPTK
C
A
Y
CTF
P
A
Y
A
IQGQ-AG
R
V
G
S
F
L
W
G
L
H
Y
E
M
-
Q
K
I
G
E
-
W
L
K
EHD-----------
V
K
V
T
T
I
Y
F-GGG--T--PTS-I-
T
-----
A
---
E
E
M
D
L
L
Y
E
E
M
V
R
SFP
D
V
K
N
I
R
E
I
TV-EA----G----RPDTI
T
-
E
E
K
L
A
V
L
NKY---D--I
D
R
I
S
INPQSY
E
N
-
E
T
L
K
A
I-G-------R---HH
T
------
V
E
E
T
I
E
K
--YH
L
S
---
R
QH--GMN-NIN---
M
D
-
L
I
I
GLP
G
-
E
G
V
K
E
-
F
R
H
S
L
---
S
----
E
T
E
K
L------M--PES---
L
T
V
H
T
---------
L
S
F
K
-----------------
R
A
S
E
M---TRN---K-
H
K
Y
KVA-
G
R
E
E
V
S
Q
---
M
M
E
D
A
V
A
W
------
T
K
EHG--YV
P
Y
---
Y
L
Y
R
Q
K
N
ILG
N
L
E
N
VGYSLPGQ----------ES--
I
Y
----------------
N
I
M
I
M
E
-
E
V
Q
T
I
I
---GIGC
G
-----
A
A
S
K
F
I-DRDTGKITHF--ANPKD
P
K
S
Y
N
E
R
F
E
H-----Y
T
D
E
K
I
K
Y
L
E
Q
I
F
E
K
TTKQH-------------------------------------------------------------------
45
Fugue
85.25
19%
-77
- C7 -
1OLT
3
HEMN_ECOLI
A:
[4-444]
-------------------------------------------------------------------
Q
Q
I
D
W
D
L
A
L
I
K
Y
Y
T
S
Y
-----------------------------------
P
T
---
A
L
E
F
S
E
D
F
G
E
Q
A
F
L
---
Q
A
-
V
A
R
----------------------------
Y
P
--
E
--
R
P
L
S
L
Y
V
H
I
P
-
F
-
C
H
K
L
C
Y
F
C
G
C
N
K
I
V
T
R
Q
Q
--
H
K
A
D
Q
Y
L
D
A
L
E
Q
E
I
-
V
H
R
A
P
-
L
F
A
G
R
-------------
H
V
S
Q
L
H
W
-
G
G
G
--
T
--
P
T
Y
-
L
-
N
-----
K
---
A
Q
I
S
R
L
M
K
L
L
R
E
N
F
Q
-
F
N
A
D
A
E
I
S
I
-
E
V
----
D
-----
P
R
E
I
E
-
L
D
V
L
D
H
L
R
A
E
---
G
--
F
N
R
L
S
M
G
V
Q
D
F
N
K
-
E
V
Q
R
L
V
-
N
-------
R
---
E
Q
D
------
E
E
F
I
F
A
L
--
L
N
H
A
---
R
E
I
--
G
F
T
-
S
T
N
---
I
D
-
L
I
Y
G
L
P
K
-
Q
T
P
E
S
-
F
A
F
T
L
---
K
----
R
V
A
E
L
------
N
--
P
D
R
---
L
S
V
F
N
---------
Y
A
H
L
P----------------
T
I
F
A
A
---
Q
R
K
---
I
-
K
D
A
D
L
P
-
S
P
Q
Q
K
L
D
---
I
L
Q
E
T
I
A
F
------
L
T
Q
S
G
--
Y
Q
F
I
GMD
H
F
A
R
P
D
D
E
L
A
V
A
Q
R
E
G
V
L
H
R
N
F
----------
Q
G
--
Y
T
----------------
T
----
Q
-
G
D
T
D
L
L
---
G
M
G
V
S
-----
A
I
S
M
I
G
-
D
------
C
Y
A
--
Q
N
Q
K
E
L
K
Q
Y
Y
Q
Q
V
D
E
QGNAL
W
R
G
I
A
L
T
R
D
D
C
I
R
R
D
V
I
K
S
L
I
C
NFRLD
Y
S
P
I
E
Q
Q
W
DLL
F
A
D
Y
F
A
E
D
L
K
L
L
A
P
L
A
K
D
GL
V
D
V
D
EK
G
I
Q
V
T
AKGRLL
I
R
N
I
C
M
C
F
DTYL
21
HHSearch
78.25
21%
-87
- C7 -
1OLT
3
HEMN_ECOLI
A:
[50-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
R
P
L
S
L
Y
V
H
I
P
-
F
-
C
H
K
L
C
Y
F
C
G
C
N
K
I
V
T
R
Q
--
Q
H
K
A
D
Q
Y
L
D
A
L
E
Q
E
I
-
V
H
R
A
P
-
L
F
A
G
-------------
R
H
V
S
Q
L
H
W
-
G
G
G
--
T
--
P
T
Y
-
L
-
N
-----
K
---
A
Q
I
S
R
L
M
K
L
L
R
E
N
F
Q
F
-
N
A
D
A
E
I
S
I
-
E
V
---------
D
P
R
E
I
E
-
L
D
V
L
D
H
L
R
A
E
---
G
--
F
N
R
L
S
M
G
V
Q
D
F
N
K
-
E
V
Q
R
L
V
-
N
-------
R
---
E
Q
D
------
E
E
F
I
F
A
L
--
L
N
H
A
---
R
E
I
--
G
F
T
-
S
T
N
---
I
D
-
L
I
Y
G
L
P
K
-
Q
T
P
E
S
-
F
A
F
T
L
---
K
----
R
V
A
E
L
------
N
--
P
D
R
---
L
S
V
F
N
---------
Y
A
H
L
-----------------
P
T
I
F
A
---
A
Q
R
---
K
I
K
D
A
D
L
P
-
S
P
Q
Q
K
L
D
---
I
L
Q
E
T
I
A
F
------
L
T
Q
S
G
--
Y
Q
F
I
---
G
------------
M
D
H
F
A
R
P
D
D
E
L
A
V
A
Q
R
E
G
V
L
H
--
R
N
----------------
F
Q
G
Y
T
T
Q
G
D
T
D
L
L
---
G
M
G
V
S
-----
A
I
S
M
I
G
-
D
------
C
Y
A
--
Q
N
Q
K
E
L
K
Q
Y
Y
Q
Q
V
D
---------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.86
23%
-104
- C7 -
1OLT
3
HEMN_ECOLI
A:
[53-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
Y
V
H
I
P
-
F
-
C
H
K
L
C
Y
F
C
G
C
N
K
-
I
V
T
R
Q
-
Q
H
K
A
D
Q
Y
L
D
A
L
E
Q
E
I
V
H
R
A
P
L
-
F
A
G
R
H
--------------
V
S
Q
L
H
W
-
G
G
G
--
T
--
P
T
Y
-
L
-
N
-----
K
---
A
Q
I
S
R
L
M
K
L
L
R
E
N
F
-
Q
F
N
A
D
A
E
I
S
I
-
E
V
----
D
-----
P
R
E
I
E
-
L
D
V
L
D
H
L
R
A
E
---
G
--
F
N
R
L
S
M
G
V
Q
D
F
N
K
-
E
V
Q
R
L
V
-
N
-------
R
---
E
Q
D
------
E
E
F
I
F
A
L
--
L
N
H
A
---
R
E
I
--
G
F
T
-
S
T
N
---
I
D
-
L
I
Y
G
L
P
K
-
Q
T
P
E
S
-
F
A
F
T
L
---
K
----
R
V
A
E
L
------
N
--
P
D
R
---
L
S
V
-----------
F
N
Y
A
-----------------
H
L
P
T
I
---
F
A
A
---
Q
-
R
K
I
K
D
A
-
D
L
P
S
P
Q
Q
K
L
D
I
L
Q
E
T
I
A
F
------
L
T
Q
S
G
--
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
69.39
18%
-52
- C7 -
4R33
5
?
A:
[35-418]
G
D
F
V
L
P
E
L
E
D
V
R
A
E
A
A
T
V
D
T
R
A
V
L
A
L
A
-----
E
G
E
E
P
A
E
S
R
A
A
V
A
L
A
L
W
E
D
R
S
-
I
G
T
A
E
L
Q
A
A
A
E
A
R
C
G
A
R
R
-----------
P
R
L
H
T
F
V
P
L
Y
T
T
N
Y
C
D
S
E
-
C
K
---------
M
C
S
M
R
K
G
---
N
H
R
L
D
R
K
F
S
G
-
R
K
E
---
I
T
-
E
Q
L
-
E
I
L
Y
H
H
E
G
V
--------
R
G
V
G
F
L
T
G
E
Y
E
-----------------------------
D
K
H
T
R
L
A
S
-
A
F
R
I
G
---
W
A
I
R
T
A
L
-
D
L
----------------------
G
F
E
R
V
Y
F
-
N
I
G
-------
S
-
M
-
E
-----
Q
---
D
E
I
D
V
L
G
E
W
I
----------------------
G
----
R
E
D
P
V
T
----
M
C
V
F
----------------
Q
E
S
Y
D
R
-
E
T
Y
R
R
F
M
G
-------
K
---
T
S
V
GVPKAD
F
D
R
R
V
V
S
--
F
D
R
W
---
L
D
A
--
G
Y
R
-
Y
V
N
---
P
G
-
V
L
V
G
L
H
D
-
D
L
S
A
E
-
L
V
S
L
V
---
A
----
H
G
D
H
L
------
R
--
S
R
G
---
A
T
A
-
D
---------
L
S
V
P
-----------------
R
M
R
P
A
---
M
K
S
---
R
-
D
T
T
R
V
--
G
D
D
D
Y
L
R
---
L
M
S
V
V
A
F
T
------
C
P
E
Q
R
--
L
V
L
T
---
T
R
E
P
Q
E
F
Q
D
V
A
L
G
L
A
G
V
I
S
P
G
---------------
S
P
----------------
D
V
A
P
Y
R
-
A
----------
G
C
E
-----
A
-------
R
N
D
E
K
S
S
Q
F
LV
A
D
L
R
R
P
R
H
I
L
G
R
I
E
A
------
S
G
T
P
V
D
H
F
V
N
P
A
G
E
A
S
R
---------------------------------------------------------------------
52
Fugue
58.78
15%
-59
- C7 -
4JC0
1
RIMO_THEMA
A:
[2-433]
-
R
V
G
I
K
V
L
G
C
P
K
N
E
A
D
C
E
V
L
A
G
V
L
R
E
G
G
H
E
I
V
F
D
V
K
D
A
D
V
V
V
L
D
T
C
A
F
I
E
D
A
K
-
R
E
S
----------------
I
D
E
I
F
S
F
V
D
A
K
D
Q
Y
G
Y
K
L
V
V
K
G
C
L
V
Q
R
Y
-------------------------------
Y
E
E
L
K
---
K
E
-
I
P
E
V
D
Q
W
I
G
V
A
D
P
E
E
I
A
N
A
I
E
T
D
L
V
P
D
R
Y
R
K
R
I
D
L
E
--
E
R
P
Y
A
Y
V
K
I
S
-
D
G
C
D
R
G
C
T
F
C
S
I
P
S
F
K
---------
G
S
L
R
S
R
S
I
E
D
I
-
T
R
E
V
E
-
D
L
L
K
E
G
-----------
K
K
E
I
I
L
V
A
-
Q
D
T
--
T
--
S
Y
G
-
I
-
D
-----
L
---
Y
R
-
K
Q
A
L
P
D
L
L
R
R
L
N
S
L
N
G
E
F
W
I
R
V
-
M
Y
----
L
----
H
P
D
H
L
T
-
E
E
I
I
S
A
M
L
E
L
---
D
KV
V
K
Y
F
D
V
P
V
Q
H
G
S
D
-
K
I
L
K
L
M
-
G
-------
R
---
T
K
S
------
S
E
E
L
K
K
M
--
L
S
S
I
---
R
E
R
--
F
P
D
A
V
L
R
---
T
S
-
I
I
V
G
F
P
G
-
E
T
E
E
D
-
F
E
E
L
K
---
Q
----
F
V
E
E
I
------
Q
--
F
D
K
---
L
G
A
F
V
---------
Y
S
D
E
-----------------
E
G
T
V
A
---
F
N
L
---
K
-
E
K
V
D
P
E
-
M
A
K
R
R
Q
E
---
E
L
L
L
L
Q
A
E
------
I
S
N
S
R
--
L
D
R
F
---
V
G
K
K
L
K
F
L
V
E
G
K
E
G
-------------------------------------------------
K
F
L
V
---
G
----------
R
T
W
T
E
-
A
P
E
V
D
G
V
V
F
V
--
R
G
K
G
K
I
G
D
F
L
E
V
V
I
K
-----
E
H
D
E
Y
-----
D
M
W
G
S
V
I
L
E
H
-------------------------------------------------------------------
35
HHSearch
57.63
14%
-125
- C7 -
2A5H
4
KAMA_CLOSU
A:
[116-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
L
L
L
I
T
D
M
-
C
S
M
Y
C
R
H
C
T
R
R
R
F
A
G
Q
----
S
D
D
S
M
P
M
E
R
I
D
K
A
I
-
D
Y
I
R
N
-
T
---
P
Q
-------------
V
R
D
V
L
L
-
S
G
G
--
D
--
A
L
L
-
V
-
S
-----
D
---
E
T
L
E
Y
I
I
A
K
L
R
E
I
P
H
----
V
E
I
V
R
I
-
G
S
RTPV
V
----
L
P
Q
R
I
T
-
P
E
L
V
N
M
L
K
K
Y
---
H
--
P
V
W
L
N
T
H
F
N
H
P
N
E
-
I
---------------------------
T
E
E
S
T
R
A
--
C
Q
L
L
---
A
D
A
--
G
V
P
--
L
G
---
N
Q
S
V
L
L
R
G
V
N
-
D
C
V
H
V
-
M
K
E
L
V
---
N
----
K
L
V
K
I
------
R
--
V
R
P
---
Y
Y
I
Y
Q
---------
C
D
L
S
-----------------
L
G
L
E
H
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
56.64
10%
-98
- C7 -
3T7V
3
PYLB_METBF
A:
[62-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
C
F
I
Y
F
S
T
Y
-
C
K
N
Q
C
S
F
C
Y
Y
N
C
R
N
E
I
----
N
R
Y
R
L
T
M
E
E
I
K
E
T
C
-
K
T
L
K
G
-----
A
G
-------------
F
H
M
V
D
L
-
T
M
G
--
E
D-
P
Y
Y
-
Y
E
D
-----
P
---
N
R
F
V
E
L
V
Q
I
V
K
E
E
L
G
-------
L
P
I
-
M
I
---------
S
P
G
L
M
D
-
N
A
T
L
L
K
A
R
E
K
---
G
--
A
N
F
L
A
L
Y
Q
E
T
Y
D
T
-
E
L
Y
R
K
L
-
R
-------
V
---
G
Q
S
------
F
D
G
R
V
N
A
--
R
R
F
A
---
K
Q
Q
--
G
Y
C
--
V
E
---
D
G
-
I
L
T
G
V
G
N
--
D
I
E
S
-
T
I
L
S
L
---
R
----
G
M
S
T
N
------
D
--
P
D
M
---
V
R
V
M
T
---------
F
L
P
Q
-----------------
E
G
T
P
L
---
E
G
F
---
R
-
D
----
K
-
S
N
L
S
E
L
K
---
I
I
S
V
L
R
L
M
------
F
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
55.98
19%
-98
- C7 -
4JC0
1
RIMO_THEMA
A:
[138-338]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
A
Y
V
K
I
S
D
G
-
C
D
R
G
C
T
F
C
S
I
P
S
F
K
G
-----
S
L
R
S
R
S
I
E
D
I
T
R
E
V
-
E
D
L
L
K
-
E
----
G
-------------
K
K
E
I
I
L
-
V
A
Q
--
D
--
T
T
S
-
Y
-
G
IDLYR
K
---
Q
A
L
P
D
L
L
R
R
L
N
S
L
N
----
G
E
F
W
I
R
V
M
Y
-----
L
----
H
P
D
H
L
T
-
E
E
I
I
S
A
M
L
E
L
---
D
KV
V
K
Y
F
D
V
P
V
Q
H
G
S
D
-
K
I
L
K
L
M
-
G
-------
R
---
T
K
S
------
S
E
E
L
K
K
M
--
L
S
S
I
---
R
E
R
FP
D
A
V
--
L
R
---
T
S
-
I
I
V
G
F
P
G
-
E
T
E
E
D
-
F
E
E
L
K
---
Q
----
F
V
E
E
I
------
Q
--
F
D
K
---
L
G
A
F
V
---------
Y
S
D
E
-----------------
E
G
T
V
A
---
F
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
54.76
13%
-77
- C7 -
4U0O
4
LIPA2_THEEB
B:
[52-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
A
T
F
L
L
L
G
P
T
-
C
T
R
A
C
A
F
C
Q
V
E
K
G
H
A
P
------
A
A
V
D
P
E
E
P
T
K
I
A
-
A
A
V
A
T
-----
L
G
-------------
L
R
Y
V
V
L
-
T
S
V
--
A
--
R
D
D
-
L
-
P
DQG--
A
---
G
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
----
G
T
E
I
E
V
-
L
S
----
P
DFRM
D
R
G
R
L
S
Q
R
D
C
I
A
Q
I
V
A
A
---
Q
--
P
A
C
Y
N
H
N
L
E
T
V
R
--
R
L
Q
G
P
V
-
R
-------
R
---
G
A
T
------
Y
E
S
S
L
R
V
--
L
A
T
V
---
K
E
L
NP
D
I
P
--
T
K
---
S
G
-
L
M
L
G
L
-
G
-
E
T
E
A
E
-
I
I
E
T
L
---
K
----
D
L
R
R
V
------
G
--
C
D
R
---
L
T
L
G
Q
---------
Y
L
P
P
-----------------
S
L
S
H
L
---
P
V
V
---
K
-----
Y
W
-
T
P
E
E
F
N
T
---
L
----
G
N
I
------
A
R
E
L
G
--
F
S
H
V
---
R
------------
S
G
P
L
V
R
S
S
Y
----------
H
A
--
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
54.53
15%
-122
* C7 *
1TV8
4
MOAA_STAA8
A:
[13-199]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
L
R
L
S
V
T
D
R
-
C
N
F
R
C
D
Y
C
M
P
K
E
V
F
G
D
D
F
--
V
F
L
P
K
N
E
L
L
T
F
D
E
M
-
A
R
I
A
K
-
V
Y
A
E
L
G
-------------
V
K
K
I
R
I
-
T
G
G
--
E
--
P
L
M
---------
R
---
R
D
L
D
V
L
I
A
K
L
N
Q
I
D
G
----
I
E
D
I
G
L
-
T
T
---------
N
G
L
L
L
K
-
K
H
-
G
Q
K
L
Y
D
A
---
G
--
L
R
R
I
N
V
S
L
D
A
I
D
D
-
T
L
F
Q
S
I
-
N
-------
N
R--
N
I
K
------
A
T
T
I
L
E
Q
--
I
D
Y
A
---
T
S
I
--
G
L
N
--
V
K
---
V
N
-
V
V
I
Q
-
K
G
-
I
N
D
D
Q
-
I
I
P
M
L
---
E
----
Y
F
K
D
K
------
H
--
I
E
----
I
R
F
I
E
---------
F
M
D
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
53.39
15%
-54
- C7 -
1R30
5
BIOB_ECOLI
A:
[27-338]
-------------------------------------------------------------------------------------------------------------------------------
R
P
R
W
T
L
S
Q
V
T
---
E
L
-
F
E
K
-
P
-------
L
L
D
L
L
F
E
A
Q
Q
V
H
R
Q
H
F
D
P
R
Q
V
--
Q
--
V
S
T
L
L
S
I
K
T
G
-
A
-
C
P
E
D
C
K
Y
C
P
----
Q
S
S
R
Y
-
K
T
G
L
E
A
E
R
L
M
E
V
E
Q
V
-
L
E
S
A
R
-
K
A
K
A
A
G
-----------
S
T
R
F
C
M
G
A
-
A
W
K
--
N
--
P
H
E
-
R
-
D
-----
M
---
P
Y
L
E
Q
M
V
Q
G
V
K
A
M
G
L
------
E
A
C
M
-
T
L
----
G
-------
T
L
S
-
E
S
Q
A
Q
R
L
A
N
A
---
G
--
L
D
Y
Y
N
H
N
L
D
T
S
-
P
-
E
F
Y
G
N
I
-
I
-------
T
---
T
R
T
------
Y
Q
E
R
L
D
T
--
L
E
K
V
---
R
D
A
--
G
I
--
K
V
C
---
S
G
-
G
I
V
G
L
-
G
-
E
T
V
K
D
-
R
A
G
L
L
---
L
----
Q
L
A
N
L
PT----
P
--
P
E
S
---
V
P
I
N
M
---------
L
V
K
V
KGTPLAD
N
D
D
V
D
A
F
D
F
I
R
T
I
A
V
---
A
R
I
M
M
P
T
-
S
Y
V
R
L
S
A
G
R
E
Q
M
N
E
---
Q
T
Q
A
M
C
F
M
A
GAN
S
I
F
Y
G
C
K
--
L
L
T
T
---
P
N
P
E
E
D
K
D
L
Q
L
F
R
K
L
G
L
N
P
Q
Q
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
52.54
16%
-89
- C7 -
4RTB
3
?
A:
[107-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
C
I
N
N
C
S
Y
C
S
F
R
R
E
N
K
E
L
---
S
R
V
R
L
S
L
E
E
A
V
D
E
A
-
K
A
I
R
E
-----
M
G
-------------
H
T
R
I
L
L
-
V
M
G
--
E
--
E
P
E
D
K
-
T
-----
L
---
S
Y
L
E
E
I
I
P
A
I
Y
S
E
V
D
-----
I
-
R
R
I
-
N
V
---------
N
I
A
P
L
T
-
L
K
G
Y
E
R
L
K
K
L
---
K
--
I
G
T
Y
Q
L
F
Q
E
S
Y
N
P
-
E
V
Y
R
E
V
-
H
-------
L
DGP
K
T
N
------
F
L
W
R
L
N
A
--
V
E
R
A
---
I
E
A
--
G
I
D
-
D
I
G
---
I
G
-
A
L
F
G
L
G
--
D
P
L
F
E
-
L
L
G
V
I
---
A
----
H
A
D
Y
L
K
K
K
FGI
G
--
P
H
T
---
V
S
V
P
R
---------
L
K
P
A
-----------------
L
N
S
V
F
---
S
N
D
---
Y
-----
K
I
-
S
D
H
K
F
K
K
---
I
V
A
L
L
R
I
M
------
L
P
Y
T
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
49.86
18%
-69
- C7 -
1R30
4
BIOB_ECOLI
A:
[75-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
C
P
E
D
C
K
Y
C
P
Q
S
S
R
Y
K
T
G
L
-
E
A
E
R
L
M
E
V
E
Q
V
L
E
S
A
-
R
K
A
K
A
-----
A
G
-------------
S
T
R
F
C
M
-
G
A
A
WK
N
--
P
H
E
-
R
-
D
-----
M
---
P
Y
L
E
Q
M
V
Q
G
V
K
A
M
-
G
-------
L
E
A
-
C
M
---------
T
L
G
T
L
S
-
E
S
Q
A
Q
R
L
A
N
A
---
G
--
L
D
Y
Y
N
H
N
L
D
T
-
S
P
-
E
F
Y
G
N
I
-
I
-------
T
---
T
R
T
------
Y
Q
E
R
L
D
T
--
L
E
K
V
---
R
D
A
--
G
I
K
--
V
C
---
S
G
-
G
I
V
G
L
-
G
-
E
T
V
K
D
-
R
A
G
L
L
---
L
----
Q
L
A
N
L
------
P
TP
P
E
S
---
V
P
I
N
M
---------
L
V
K
V
-----------------
K
G
T
P
L
---
A
D
N
---
D
-----
D
V
-
D
A
F
D
F
I
R
---
T
I
A
V
A
R
I
M
------
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
48.87
17%
-101
- C3 -
5AHR
2
A:
[1-343]
-------------------------------------------------
S
M
T
C
-
P
F
Y
K
K
I
P
G
T
G
--------
F
T
V
D
A
F
Q
---
Y
G
V
V
E
G
C
T
A
Y
F
L
T
H
F
H
S
D
H
Y
A
G
L
S
K
H
F
T
F
P
V
Y
C
S
E
I
T
G
N
L
L
K
N
K
L
--
H
V
Q
E
Q
Y
I
H
---
P
L
P
L
D
T
-
E
C
I
V
N
G
V
K
V
V
L
L
D
--
A
N
H
C
P
G
A
V
M
I
L
F
Y
L
--
P
--
N
G
T
V
I
L
H
----------------------------
T
G
D
F
R
A
D
P
S
M
E
R
-
S
L
L
A
D
--
Q
K
V
H
M
-----------
L
Y
L
D
T
T
Y
C
------
S
--
P
E
Y
-
T
-
F
-----
P
---
S
Q
Q
E
V
I
R
F
A
I
N
T
A
F
E
A
V
T
L
N
P
H
A
L
V
-
V
C
----
G
----
T
Y
S
I
G
K
-
E
K
V
F
L
A
I
A
D
V
---
L
--
G
S
K
V
G
M
S
Q
E
K
Y
K
T
L
Q
C
L
N
I
P
-
E
-------
I
---
N
S
L
------
I
T
T
D
M
C
S
SL
V
H
L
L
---
P
-----
M
M
-
Q
I
N
---
F
K
-
G
L
Q
S
H
L
K
-
K
C
G
G
K
-
Y
N
Q
I
L
---
A
----
F
R
P
T
V
------
I
--
P
Q
T
K
GN
I
S
I
Y
G
I
PYSEHSS
Y
L
E
M
K
-----------------
R
F
V
Q
W
L
KP
Q
K
I
---
I
-
P
T
V
N
V
G
-
T
W
K
S
R
S
T
---
M
E
K
Y
F
R
E
W
------
K
L
E
A
G
--
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
48.25
15%
-58
- C1 -
2X6Q
-
TRET_PYRHO
A:
[2-414]
K
M
Y
E
V
K
-------
K
R
K
L
E
D
Y
K
S
I
I
---------
G
E
E
E
V
S
K
I
Q
E
K
A
E
K
L
K
G
R
S
F
V
H
V
N
S
T
S
F
G
G
G
--------------
V
A
E
I
L
H
S
L
V
P
L
L
R
S
I
----------
G
I
E
A
R
W
F
--
V
I
E
G
P
T
E
F
F
N
V
T
K
T
F
H
N
A
L
Q
G
N
E
S
L
K
L
T
E
E
-
M
K
E
-
L
Y
L
N
V
N
R
E
N
S
K
F
I
D
L
S
S
F
D
Y
V
L
V
H
D
-------------------------------
P
Q
P
A
A
L
I
E
F
-
Y
E
K
K
S
P
W
L
W
R
C
H
I
D
L
-
S
------------------------------------
S
--
P
N
R
-
E
-
F
-----
W
---
E
F
L
R
R
F
V
E
K
Y
D
R
Y
I
F
H
L
P
E
Y
V
Q
P
E
L
-
D
R
----
N
----
K
A
V
I
M
P
-
P
-------------------
S
I
D
P
L
S
E
K
N
-
V
E
L
K
---------------
Q
T
E
------
I
L
R
I
L
E
R
--
F
D
V
D
---
P
E
K
-------------
P
-
I
I
T
Q
V
S
R
F
D
P
W
K
G
-
I
F
D
V
I
---
E
----
I
Y
R
K
V
------
K
--
E
K
I
---
P
G
V
Q
L
---------
L
L
V
G
-----------------
V
M
A
H
D
---
D
P
E
---
G
-
W
I
Y
F
E
K
-
T
L
R
K
I
G
E
---
D
-
Y
D
V
K
V
L
------
T
N
L
I
G
--
V
H
-------
A
R
E
V
N
A
F
Q
R
A
S
D
V
I
L
Q
M
S
I
R
----------
E
G
FG
L
T
----------------
V
T
E
A
M
W
-
K
G
K
P
V
I
---
G
R
A
V
G
-----
G
I
K
F
Q
I
V
D
G
E
T
G
F
L
V
R
----
D
A
N
E
A
V
E
V
V
L
Y
L
L
K
-----
H
P
E
V
S
K
E
M
G
A
K
A
K
E
R
V
R
K
N
F
I
I
T
K
H
M
E
R
Y
L
D
I
L
N
S
L---------------------------------------------------
30
HHSearch
47.37
13%
-91
- C7 -
4WCX
6
?
A:
[97-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Y
V
S
N
Y
-
C
V
N
N
C
R
Y
C
G
Y
R
H
S
N
E
Q
----
Q
R
K
K
L
T
M
E
E
V
R
R
E
V
-
E
I
L
E
E
-----
M
G
-------------
H
K
R
L
A
V
-
E
A
G
--
E
--
D
P
V
N
C
-
P
-----
I
---
D
Y
I
V
D
V
I
K
T
I
Y
D
T
K
L
--
K
N
G
S
I
R
R
V
-
N
V
---------
N
I
A
A
T
T
-
V
E
N
Y
K
K
L
K
K
V
---
G
--
I
G
T
Y
V
L
F
Q
E
T
Y
H
R
-
P
T
Y
E
Y
M
-
H
PQG----
P
---
K
H
D
------
Y
D
Y
H
L
T
A
--
M
D
R
A
---
M
E
A
--
G
I
D
-
D
V
G
---
L
G
-
V
L
Y
G
L
Y
D
-
Y
K
Y
E
T
-
V
A
M
L
Y
H
A
N
H
----
L
E
E
K
F
GV----
G
--
P
H
T
---
I
S
V
P
R
---------
L
R
P
A
-----------------
L
N
I
S
I
---
D
K
F
---
P
----
Y
I
V
-
S
D
K
D
F
K
K
---
L
V
A
V
I
R
M
A
------
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
47.14
13%
-84
- C7 -
4R33
4
?
A:
[108-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Y
T
T
N
Y
-
C
D
S
E
C
K
M
C
S
M
R
K
G
N
H
R
L
---
D
R
K
F
S
G
R
K
E
I
T
E
Q
L
-
E
I
L
Y
H
----
H
E
G
-------------
V
R
G
V
G
F
-
L
T
G
--
E
--
Y
E
D
---
K
-----
H
T
R
L
A
S
A
F
R
I
G
W
A
I
R
T
A
L
D
L
---
G
F
-
E
R
V
-
Y
F
---------
N
I
G
S
M
E
-
Q
D
E
I
D
V
L
G
E
W
I
GR
E
D-
P
V
T
M
C
V
F
Q
E
S
Y
D
R
-
E
T
Y
R
R
F
-
M
GKTSVGV
P
---
K
A
D
------
F
D
R
R
V
V
S
--
F
D
R
W
---
L
D
A
--
G
Y
R
-
Y
V
N
---
P
G
-
V
L
V
G
L
H
D
-
D
L
S
A
E
-
L
V
S
L
V
---
A
H
G
D
-
H
L
R
S
R
------
G
A
-
T
A
D
---
L
S
V
P
R
---------
M
R
P
A
-----------------
M
K
S
R
D
---
T
----------
T
R
V
-
G
D
D
D
Y
L
R
---
L
M
S
V
V
A
F
T
------
C
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
46.63
13%
-93
- C7 -
4FHD
5
?
A:
[108-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
A
I
P
L
A
T
G
-
C
M
G
H
C
H
Y
C
Y
L
Q
T
T
L
G
S
K
P
-
Y
I
R
V
Y
V
N
L
D
D
I
F
A
Q
A
-
Q
K
Y
I
N
----
E
R
A
-------------
P
E
I
T
R
F
-
E
A
A
--
C
TS
D
I
V
G
I
-
D
-----
H
LT-
H
S
L
K
K
A
I
E
F
I
G
A
T
-----
D
Y
G
R
L
R
F
-
V
T
---------
K
Y
E
H
V
---
D
H
L
L
D
A
R
H
N
---
G
--
K
T
R
F
R
F
S
I
N
S
--
R
-
Y
V
I
N
H
F
-
E
P------
G
---
T
S
S
------
F
D
G
R
L
A
A
--
A
R
K
V
---
A
G
A
--
G
Y
K
--
L
G
---
F
V
-
V
A
P
I
Y
R
H
-
E
G
W
E
R
G
Y
F
E
L
F
---
Q
E
L
A
R
Q
L
E
G
M
------
D
--
L
S
D
---
L
T
F
E
L
---------
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
46.22
14%
-84
- C7 -
2YX0
-
TYW1_PYRHO
A:
[79-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
W
-
C
T
H
N
C
I
F
C
W
R
P
M
E
N
F
L
G
T
E
L
P
Q
P
W
D
D
P
A
F
I
V
E
E
S
-
I
K
A
Q
R
K
L
L
I
G
Y
K
PKVDK
K
K
F
E
E
A
W
N
P
T
H
A
A
I
S
L
S
G
--
E
--
P
M
L
---
Y
---------
P
Y
M
G
D
L
V
E
E
F
H
K
R
-
G
-----
F
T
T
F
I
-
V
T
---------
N
G
T
I
P
E
--
R
L
E
E
M
I
K
E
D
K--
L
--
P
T
Q
L
Y
V
S
I
T
A
P
D
I
-
E
T
Y
N
S
V
-
N
-------
I
PMI
P
D
G
------
W
E
R
I
L
R
F
--
L
E
L
M
---
R
D
L
--
P
T
R
--
T
V
---
V
R
-
L
T
L
V
-
K
G
-
E
N
M
H
S
-
P
E
K
Y
A
---
K
----
L
I
L
K
A
------
R
--
P
M
F
---
V
E
A
K
A
---------
Y
M
-----------------------
N
---
R
L
T
---
I
-
N
--
N
M
P
-
S
H
Q
D
I
R
E
---
F
A
E
A
L
V
K
H
------
L
P
G
Y
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
45.75
17%
7
- C2 -
4K3C
-
?
A:
[262-793]
-----
Y
N
I
S
E
M
R
I
I
G
D
T
Q
K
L
D
N
E
L
N
Q
L
L
T
H
F
K
A
G
Q
L
F
R
K
T
E
L
S
I
I
E
E
Q
I
K
Q
I
L
-
G
D
R
G
--
Y
G
S
A
K
V
D
L
Y
P
K
F
N
E
E
D
H
T
V
Q
I
N
F
I
V
D
A
G
R
R
I
Y
V
R
K
I
R
F
E
-
G
-
N
D
V
T
A
D
S
T
--
L
R
R
E
M
R
Q
Q
E
---
G
A
W
L
S
T
S
A
V
S
L
A
K
---
S
R
-
L
E
R
-
T
G
--
F
Y
E
T
V
E
M
S
M
P
T
V
K
N
T
D
D
Q
V
D
I
I
Y
K
I
--
K
E
R
N
T
G
S
I
N
F
G
V
G
-
Y
-
G
S
G
S
--
G
L
S
Y
N
A
G
I
T
Q
D
N
-
F
L
G
M
G
S
S
L
-
G
L
N
G
S
R
-
N
T
D
S
T
-
N
V
N
L
S
Y
-----------
T
E
P
Y
F
T
K
D
-
G
V
S
--
L
--
G
G
N
-
I
-
F
-----
Y
---
E
D
Y
D
--
N
S
A
R
K
A
S
A
A
Y
K
R
K
T
Y
G
A
S
G
-
T
L
----
G
----
F
P
--------------
V
---
D
--
E
N
N
S
Y
Y
L
G
L
G
Y
T
H
-
D
K
L
R
N
V
-
E
-------
R
---
E
Y
T
------
R
E
K
Y
V
N
S
--
M
K
F
P
I
N
P
Q
N
S
--
H
Y
D
-
R
I
Q
S
A
D
F
D
-
L
S
F
G
W
N
Y
-
N
N
L
N
R
-
G
Y
F
P
T
---
A
----
G
S
S
A
N
------
I
--
S
G
K
---
L
T
L
P
G
---------
S
D
N
K
-----------------
Y
Y
Q
V
G
---
T
N
F
---
S
-
G
Y
I
P
L
N
-
S
E
H
K
W
V
I
---
A
T
K
G
G
L
A
Y
------
T
N
S
F
G
GK
E
V
P
F
---
Y
Q
L
Y
S
A
G
G
M
G
S
L
R
G
F
A
G
G
S
I
G
P
----------
K
A
--
I
Y
Y
REDGFKAPSQDVIGG
N
A
M
V
N
A
-
S
L
E
L
I
I
P
AP
F
I
S
D
K
YQHN
V
R
T
S
V
F
V
-
D
A
A
T
V
W
N
T
K
W
--
K
Q
S
K
A
D
Y
P
N
L
P
D
F
G
D
-----
Y
K
R
V
R
A
S
A
G
I
A
L
Q
W
Q
S
P
I
G
P
L
S
F
S
Y
A
K
P
IKKYAG
D
E
I
E
Q
F
Q
F
T
V
G
S
T
F---------------------------------------