@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10200: (2016-06-16 )
MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVRNHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEYCQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIGVGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNNEEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQLAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTAKLLYYYVQSPMV
Atome Classification :
(20 SA)
.........10........20....-....30......----..40.-------------...-...-.50.......-.60......-..70........---80.....--...90........100....----...110---------.........120.......130-......--..140----...---......150.--------------......160.-......170.--------.---.-..-..180.......190.......200.......210.......220.....----.----.230-------------------------.------........--240...-.---.---------.------.250------.------..--------..-.------.260.-----..----....270.......280.......-290--.-........300.......310.......320........330.......340....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
S
V
R
K
T
M
E
L
I
K
E
L
VSIPSPTG
N
T
Y
-
E
V
I
N
Y
I
E
S
L
L
K
E----W
K
V
E
T
-------------
V
RN-HKG-
G
L
I
A
TLPGRD-TSR
H
R
M
L
T
A
-
H
V
D
T
L
G
A
M
V
K
E
I---KAD
G
R
L
K
--
I
D
L
IG
G
F
R
YNSIEG
E
Y
C
Q
I
E
----TASG-----------
K
M
Y
T
G
T
I
L
M
H
Q
T
S
V
H
V
Y
KDAG--KAERNQ--EN
M
------
E
I
R---LDEPVHCRK
D
--------------
T
E
E
LGIGVGD-FVSFDP
R
V
E
I
--------T---S-SG-
F
I
KSRHLD
D
K
A
S
V
A
L
L
L
R
L
I
H
E
IQTEDIELP
Y
T
T
H
F
L
I
SNNEEIGYGGNS----N----I
P
---------------------------
P
------
E
T
V
E
Y
L
A
V
--
D
MGAIG-D---G---------Q------ATD
E
------
Y
------
S
V
--------
S
I
-
C
------
V
KDAS-----GP----
Y
H
Y
Q
L
R
K
H
L
V
Q
L
A
E
KHHI
D
Y
K
L
D
I
-
Y
----
P
-YYGSD
A
S
A
A
I
KSG
H
D
I
V
H
G
L
IGPGI
D
A
S
H
A
-
F
E
R
T
H
K
S
S
L
R
H
T
A
K
L
L
Y
Y
Y
VQSPMV
1
PsiBlast_PDB
97.68
70%
-103
- C2 -
2GRE
1
?
A:
[6-347]
----
K
E
T
M
E
L
I
K
E
L
V
S
I
P
S
P
S
G
N
T
A
-
K
I
I
N
F
I
E
N
Y
V
S
E
----
W
N
V
E
T
-------------
K
R
N
-
N
K
G
-
A
L
I
L
T
V
K
G
K
N
-
D
A
Q
H
R
L
L
T
A
-
H
V
D
T
L
G
A
M
V
K
E
I
---
K
P
D
G
R
L
S
--
L
S
M
I
G
G
F
R
W
N
S
V
E
G
E
Y
C
E
I
E
----
T
S
S
G
-----------
K
T
Y
T
G
T
I
L
M
H
-----------------------
I
------
E
V
R
---
I
D
E
R
V
F
S
A
D
E
--------------
V
R
E
L
G
I
E
V
G
D
-
F
V
S
F
D
P
R
V
Q
I
--------
T
---
E
-
S
G
-
Y
I
K
S
R
H
L
D
D
K
V
S
V
A
I
L
L
K
L
I
K
R
L
Q
D
E
N
V
T
L
P
Y
T
T
H
F
L
I
S
N
N
E
----
G
G
N
S
----
N
----
I
P
---------------------------
E
------
E
T
V
E
Y
L
A
V
--
D
M
G
A
L
G
-
D
---
G
-----------------
S
D
E
------
Y
------
T
V
--------
S
I
-
C
------
A
K
D
S
S
-----
G
P
----
Y
H
Y
A
L
R
K
H
L
V
E
L
A
K
T
N
H
I
E
Y
K
V
D
I
-
Y
----
P
-
Y
Y
--------
R
A
G
F
D
V
K
H
A
L
I
G
A
G
I
D
S
S
H
A
-
F
E
R
T
H
E
S
S
I
A
H
T
E
A
L
V
Y
A
Y
V
M
S
N
L
I
21
HHSearch
97.05
71%
-99
- C2 -
2GRE
1
?
A:
[3-346]
-
H
H
T
K
E
T
M
E
L
I
K
E
L
V
S
I
P
S
P
S
G
N
T
A
-
K
I
I
N
F
I
E
N
Y
V
S
E
----
W
N
V
E
T
-------------
K
R
N
-
N
K
G
-
A
L
I
L
T
V
K
G
K
N
-
D
A
Q
H
R
L
L
T
A
-
H
V
D
T
L
G
A
M
V
K
E
I
---
K
P
D
G
R
L
S
--
L
S
M
I
G
G
F
R
W
N
S
V
E
G
E
Y
C
E
I
E
----
T
S
S
G
-----------
K
T
Y
T
G
T
I
L
M
H
---------------------
I
E
--------
V
R
---
I
D
E
R
V
F
S
A
D
E
--------------
V
R
E
L
G
I
E
V
G
D
-
F
V
S
F
D
P
R
V
Q
I
--------
T
---
E
-
S
G
-
Y
I
K
S
R
H
L
D
D
K
V
S
V
A
I
L
L
K
L
I
K
R
L
Q
D
E
N
V
T
L
P
Y
T
T
H
F
L
I
S
N
N
E
----
G
G
N
S
----
N
----
I
P
---------------------------
E
------
E
T
V
E
Y
L
A
V
--
D
M
G
A
L
G
-
D
---
G
-----------------
S
D
E
------
Y
------
T
V
--------
S
I
-
C
------
A
K
D
S
S
-----
G
P
----
Y
H
Y
A
L
R
K
H
L
V
E
L
A
K
T
N
H
I
E
Y
K
V
D
I
-
Y
----
P
-
Y
Y
--------
R
A
G
F
D
V
K
H
A
L
I
G
A
G
I
D
S
S
H
A
-
F
E
R
T
H
E
S
S
I
A
H
T
E
A
L
V
Y
A
Y
V
M
S
N
L
-
30
HHSearch
69.70
19%
-92
- C2 -
1YLO
2
?
A:
[3-337]
----
A
M
D
L
S
L
L
K
A
L
S
E
A
D
A
I
A
S
S
E
Q
-
E
V
R
Q
I
L
L
E
E
A
A
R
----
L
Q
K
E
V
-------------
R
F
D
-
G
L
G
-
S
V
L
I
R
L
N
E
S
--
T
G
P
K
V
M
I
C
A
-
H
M
D
E
V
G
F
M
V
R
S
I
---
S
R
E
G
A
I
D
--
V
L
P
V
G
N
V
R
M
A
A
R
Q
L
Q
P
V
R
I
T
----
T
R
E
E
-----------
C
K
I
P
G
L
L
D
G
D
-------------
R
Q
G
N
D
V
--
S
A
--------
M
R
---
V
D
I
G
A
R
T
Y
D
E
--------------
V
M
Q
A
G
I
R
P
G
D
-
R
V
T
F
D
T
T
F
Q
V
--------
L
---
P
-
H
Q
-
R
V
M
G
K
A
F
D
D
R
L
S
C
Y
L
L
V
T
L
L
R
E
L
H
D
A
--
E
L
P
A
E
V
W
L
V
A
S
S
S
E
E
V
G
L
R
G
G
Q
----
T
----
A
T
---------------------------
R
A
V
----
S
P
D
V
A
I
V
L
--
D
T
A
C
W
A
-
K
---
N
FD-------
Y
GAANH-
R
Q
I
G
------
N
------
G
P
--------
M
L
-
V
------
L
S
D
K
S
-----
L
I
----
A
P
P
K
L
T
A
W
I
E
T
V
A
A
E
I
G
V
P
L
Q
A
D
M
-
F
----
S
-
N
G
G
T
D
G
G
A
V
H
L
T
G
T
G
V
P
T
L
V
M
G
P
A
T
R
H
G
H
C
A
A
S
I
A
D
C
R
D
I
L
Q
M
E
Q
L
L
S
A
L
I
Q
R
L
T
-
27
HHSearch
67.48
20%
-91
- C2 -
5DS0
3
?
A:
[2-351]
--
N
A
D
K
S
M
E
L
M
K
T
L
M
E
A
F
G
P
S
G
F
E
R
-
E
V
N
A
I
C
K
E
Y
M
E
P
----
Y
A
D
E
V
-------------
V
V
D
-
K
L
G
-
S
V
T
F
I
A
K
G
N
--
D
R
P
R
I
L
M
A
G
-
H
T
D
E
V
G
F
I
V
S
S
I
---
S
K
E
G
Y
L
T
--
F
N
T
L
G
G
W
W
S
Q
V
L
L
G
Q
R
V
V
V
R
----
T
C
K
G
------------
M
V
H
G
I
I
A
S
K
--
P
P
H
I
L
P
P
D
E
R
-
K
K
I
V
E
A
--
R
D
--------
M
F
---
I
D
I
G
A
T
S
E
E
E
--------------
A
E
E
S
G
V
K
V
G
D
-
P
I
V
P
W
S
P
F
S
V
--------
I
---
Q
-
N
G
R
V
A
M
G
K
A
F
D
D
R
I
G
A
F
V
L
M
E
A
I
R
R
M
K
D
Q
G
I
E
H
P
N
T
V
Y
G
S
A
T
V
Q
E
E
V
G
L
R
G
A
Q
----
T
----
T
A
---------------------------
H
V
V
----
D
P
D
V
A
L
V
L
E
V
D
I
A
G
D
V
-
P
--------------KPHEAL
T
K
M
G
------
K
------
G
P
--------
G
L
-
V
------
T
Y
D
R
S
-----
M
I
----
P
N
Q
P
L
K
E
F
V
I
N
V
A
K
Q
A
Q
I
P
L
Q
L
S
Q
-
M
----
S
-
G
G
G
T
D
A
G
R
I
H
M
N
R
A
G
C
P
S
V
V
I
T
I
P
T
R
H
I
H
S
H
V
G
L
L
S
L
K
D
T
E
N
A
I
R
L
V
I
E
L
I
K
R
L
D
-
25
HHSearch
65.60
22%
-81
- C2 -
1VHE
1
YSDC_BACSU
A:
[5-353]
--
K
L
D
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
N
E
R
-
E
V
R
Q
V
M
K
S
Y
I
E
P
----
F
A
D
E
V
-------------
T
T
D
-
R
L
G
-
S
L
I
A
K
K
T
G
A
E
-
N
G
P
K
I
M
I
A
G
-
H
L
D
E
V
G
F
M
V
T
Q
I
---
T
D
K
G
F
I
R
--
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
Q
R
V
T
I
V
----
T
K
K
G
------------
E
I
T
G
V
I
G
S
K
--
P
P
H
I
L
S
P
E
A
R
-
K
K
S
V
E
I
--
K
D
--------
M
F
---
I
D
I
G
A
S
S
R
E
E
--------------
A
L
E
W
G
V
L
P
G
D
-
M
I
V
P
H
F
E
F
T
V
--------
M
---
N
N
E
K
-
F
L
L
A
K
A
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
Q
N
T
--
D
H
P
N
I
V
Y
G
V
G
T
V
Q
E
E
V
G
L
R
G
A
K
----
T
----
A
A
---------------------------
H
T
I
----
Q
P
D
I
A
F
G
V
--
D
V
G
I
A
G
-
D
---
T
PGISEKEA-
Q
------
S
K
M
G
------
K
------
G
P
--------
Q
I
-
I
------
V
Y
D
A
S
-----
M
V
----
S
H
K
G
L
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
-
I
----
A
-
G
G
G
T
D
S
G
A
I
H
L
T
A
N
G
V
P
A
L
S
I
T
I
A
T
R
Y
I
H
T
H
A
A
M
L
H
R
D
D
Y
E
N
A
V
K
L
I
T
E
V
I
K
K
L
D
-
24
HHSearch
64.83
22%
-91
- C2 -
2FVG
3
?
A:
[2-333]
--------
M
Y
L
K
E
L
S
M
M
P
G
V
S
G
D
E
G
-
K
V
R
D
F
I
K
S
K
I
E
G
----
L
V
D
N
L
-------------
Y
T
D
-
V
L
G
-
N
L
I
A
L
K
R
G
R
D
-
S
S
K
K
L
L
V
S
A
-
H
M
D
E
V
G
F
V
V
S
K
I
---
E
K
D
G
K
V
S
--
F
L
P
V
G
G
V
D
P
R
I
L
P
G
K
V
V
Q
V
K
----
N
----------------
L
K
G
V
I
G
Y
R
---------------
P
P
R
F
--
E
N
--------
L
R
---
I
D
F
G
F
S
S
A
D
E
--------------
A
K
K
-
Y
V
S
I
G
D
-
Y
V
S
F
V
S
D
Y
I
E
------------
K
-
N
G
-
R
A
V
G
K
A
F
D
D
R
A
G
C
S
V
L
I
D
V
L
E
S
G
V
S
----
P
A
Y
D
T
Y
F
V
F
T
V
Q
E
E
-----
S
A
----
V
----
V
V
---------------------------
E
Q
L
----
K
P
T
C
A
I
V
V
--
E
T
T
T
A
G
-
D
---
N
PELEERKW-
A
------
T
H
L
G
------
D
------
G
P
--------
A
I
-
T
------
F
Y
H
R
G
-----
Y
V
----
I
P
K
E
I
F
Q
T
I
V
D
T
A
K
N
N
D
I
P
F
Q
M
K
R
-
R
----
T
--------------
Y
G
V
P
A
G
V
I
S
T
P
A
R
Y
I
H
S
P
N
S
I
I
D
L
N
D
Y
E
N
T
K
K
L
I
K
V
L
V
E
E
G
--
31
HHSearch
64.66
20%
-87
- C2 -
2WZN
6
?
A:
[8-348]
---
S
M
V
D
W
K
L
M
Q
E
I
I
E
A
P
G
V
S
G
Y
E
H
L
G
I
R
D
I
V
V
D
V
L
K
E
----
V
A
D
E
V
-------------
K
V
D
-
K
L
G
-
N
V
I
A
H
F
K
G
S
---
S
P
R
I
M
V
A
A
-
H
M
D
K
I
G
V
M
V
N
H
I
---
D
K
D
G
Y
L
H
--
I
V
P
I
G
G
V
L
P
E
T
L
V
A
Q
R
I
R
F
F
----
T
E
K
G
------------
E
R
Y
G
V
V
G
V
L
--
P
P
H
L
R
---------
I
D
W
--
D
Q
--------
I
V
---
V
D
V
G
A
S
S
K
E
E
--------------
A
E
E
M
G
F
R
V
G
T
-
V
G
E
F
A
P
N
F
T
R
--------
L
---
N
-
E
H
-
R
F
A
T
P
Y
L
D
D
R
I
C
L
Y
A
M
I
E
A
A
R
Q
L
G
D
----
H
E
A
D
I
Y
I
V
G
S
V
Q
E
E
V
G
L
R
G
A
R
----
V
----
A
S
---------------------------
Y
A
I
----
N
P
E
V
G
I
A
M
--
D
V
T
F
A
K
-
Q
---
P
---------
H
DKGKIV
P
E
L
G
------
K
------
G
P
--------
V
M
-
D
------
V
G
P
--------
N
----
I
N
P
K
L
R
A
F
A
D
E
V
A
K
K
Y
E
I
P
L
Q
V
E
P
-
S
P---
R
-
P
T
G
T
D
A
N
V
M
Q
I
N
K
E
G
V
A
T
A
V
L
S
I
P
I
R
Y
M
H
S
Q
V
E
L
A
D
A
R
D
V
D
N
T
I
K
L
A
K
A
L
L
E
E
L
K
-
26
HHSearch
64.21
21%
-71
- C2 -
3KL9
2
?
A:
[2-345]
---
M
T
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
A
-
P
V
R
A
Y
L
R
E
K
L
T
P
----
H
V
D
E
V
-------------
V
T
D
-
G
L
G
-
G
I
F
G
I
K
H
S
E
A
V
D
A
P
R
V
L
V
A
S
-
H
M
D
E
V
G
F
M
V
S
E
I
---
K
P
D
G
T
F
R
--
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
----
T
R
D
G
-----------
H
E
I
P
V
I
S
G
------------------
P
A
I
--
A
D
--------
I
V
---
F
D
G
G
F
A
D
K
A
E
--------------
A
E
S
F
G
I
R
P
G
D
-
T
I
V
P
D
S
S
A
I
L
--------
T
A--
N
-
E
K
-
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
G
Q
--
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
----
T
----
S
T
---------------------------
T
K
F
----
D
P
E
V
F
L
A
V
--
D
C
S
P
A
G
-
D
---
V
---------
Y
GGQ---
G
K
I
G
------
D
------
G
T
--------
L
I
-
R
------
F
Y
D
P
G
-----
H
L
----
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
-
G
------
K
G
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
-
28
HHSearch
63.34
22%
-89
- C2 -
3ISX
3
?
A:
[12-342]
-----
H
M
K
E
L
I
R
K
L
T
E
A
F
G
P
S
G
R
E
E
-
E
V
R
S
I
I
L
E
E
L
E
G
----
H
I
D
G
H
-------------
R
I
D
-
G
L
G
-
N
L
I
V
W
K
G
S
---
G
E
K
K
V
I
L
D
A
-
H
I
D
E
I
G
V
V
V
T
N
V
---
D
D
K
G
F
L
T
--
I
E
P
V
G
G
V
S
P
Y
M
L
L
G
K
R
I
R
F
E
----
N
G
---------------
T
I
G
V
V
G
M
E
--
G
E
T
T
E
E
R
Q
E
N
-
V
R
K
L
S
F
--
D
K
--------
L
F
---
I
D
I
G
A
N
S
R
E
E
--------------
A
Q
K
M
-
C
P
I
G
S
-
F
G
V
Y
D
S
G
F
V
E
--------
V
-----
S
G
-
K
Y
V
S
K
A
M
D
D
R
I
G
C
A
V
I
V
E
V
F
K
R
I
K
-----
P
A
V
T
L
Y
G
V
F
S
V
Q
E
E
V
G
L
V
G
A
S
----
V
----
A
G
---------------------------
Y
GV----
P
A
D
E
A
I
A
I
--
D
V
T
D
S
A
-
D
---
T
PKAIKRH--
A
------
M
R
L
S
------
G
------
G
P
--------
A
L
-
K
------
V
K
D
R
A
-----
S
I
----
S
S
K
R
I
L
E
N
L
I
E
I
A
E
K
F
D
I
K
Y
Q
M
E
V
-
L
----
T
-
F
G
G
T
N
A
M
G
Y
Q
R
T
R
E
G
I
P
S
A
T
V
S
I
P
T
R
Y
V
H
S
P
S
E
M
I
A
P
D
D
V
E
A
T
V
D
L
L
I
R
Y
L
G
----
29
HHSearch
62.55
24%
-88
- C2 -
4WWV
-
?
A:
[5-355]
--
W
R
G
Q
Y
I
E
L
I
K
K
L
T
S
L
H
A
P
S
G
R
E
D
-
P
V
K
D
L
V
A
E
L
M
K
S
----
H
V
D
K
L
-------------
W
I
D
-
V
W
G
-
N
V
V
G
Y
R
K
G
S
K
-
G
S
G
K
I
M
I
A
A
-
H
M
D
E
I
G
L
F
I
S
H
I
---
E
D
D
G
F
L
R
--
V
I
P
I
G
G
V
L
E
R
T
L
L
Y
Q
R
V
V
V
R
----
T
R
D
G
-----------
R
L
Y
R
G
V
I
G
L
K
--
P
P
H
V
I
---
E
A-
Q
K
V
P
E
L
--
R
E
--------
L
F
---
I
D
V
G
A
S
S
K
E
E
--------------
V
E
K
M
G
I
R
V
G
D
-
I
A
V
F
D
R
E
V
A
E
--------
L
---
G
-
W
N
-
R
I
T
S
K
A
F
D
D
R
V
G
V
V
V
M
L
K
A
L
E
M
L
E
K
----
H
D
V
D
V
Y
L
V
A
T
V
Q
E
E
V
G
L
K
G
A
K
----
T
----
S
A
---------------------------
Y
G
I
----
S
P
D
V
A
L
A
I
--
D
V
T
I
A
S
-
D
VP-
G
VAKSEW---
F
------
T
R
L
G
------
Y
------
G
P
--------
A
I
-
K
------
I
V
D
G
R
NAGG-
L
I
----
A
H
P
K
V
G
E
F
L
V
S
I
A
E
K
K
R
I
P
Y
Q
L
D
V
-
I
----
S
-
G
G
T
T
D
A
S
T
I
A
L
N
K
E
G
V
A
A
G
T
I
S
I
P
S
R
Y
I
H
S
P
V
E
V
V
D
L
R
D
L
Y
N
A
S
L
L
A
K
A
F
I
E
E
A
T
-
33
HHSearch
61.81
22%
-89
* C2 *
2WYR
2
?
A:
[2-332]
----
M
S
M
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
-
R
I
R
E
E
I
I
R
E
I
K
D
----
F
A
-
D
Y
-------------
K
V
D
-
A
I
G
-
N
L
I
V
E
L
G
E
---
G
E
E
R
I
L
F
M
A
-
H
M
D
E
I
G
L
L
I
T
G
I
---
T
D
E
G
K
L
R
--
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
----
T
E
K
G
------------
I
L
D
G
V
I
G
A
T
--
P
P
H
L
-------
K
S
V
I
P
W
--
Y
D
--------
L
V
---
I
D
I
G
A
E
S
K
E
E
--------------
A
L
E
-
L
V
K
P
L
D
-
F
A
V
F
K
K
H
F
S
V
--------
L
---
N
-
G
K
-
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
D
H
--
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
----
F
----
L
A
---------------------------
N
H
Y
----
Y
P
Q
Y
A
F
A
I
--
D
S
F
A
C
C
-
S
---
P
LTG------
D
------
V
K
L
G
------
K
------
G
P
--------
V
I
-
R
------
A
V
D
N
S
-----
A
I
----
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
-
T
------
G
G
G
T
D
A
S
A
F
--
Q
-
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
E
A
L
A
F
E
L
--
36
HHSearch
61.36
21%
-96
- C2 -
1VHO
4
?
A:
[5-335]
----
M
E
T
G
K
L
L
M
E
L
S
N
L
D
G
P
S
G
Y
E
T
-
N
V
V
S
Y
I
K
S
V
I
E
P
----
F
V
D
E
A
-------------
K
T
T
-
R
H
G
-
S
L
I
G
Y
K
K
G
K
--
G
I
G
K
L
A
F
F
A
-
H
V
D
E
I
G
F
V
V
S
K
V
---
E
-
G
Q
F
A
R
--
L
E
P
V
--------
Y
A
S
K
V
R
I
Y
----
T
K
N
G
------------
I
E
R
G
V
I
G
M
L
--
A
P
H
L
Q
D
S
E
S
R
-
K
K
V
P
T
Y
--
D
E
--------
I
F
---
V
D
L
S
L
--------------------
C
E
R
G
V
R
V
G
D
-
I
A
V
I
D
Q
T
A
F
E
--------
T
-----
N
G
-
K
V
V
G
K
A
L
D
N
R
A
S
C
G
V
L
V
K
V
L
E
F
L
K
R
Y
--
D
H
P
W
D
V
Y
V
V
F
S
V
Q
E
E
T
G
C
L
G
A
L
----
T
----
G
A
---------------------------
Y
EI----
N
P
D
A
A
I
V
M
--
D
V
T
F
A
S
-
E
---
P
---------
P
F
S
D
H
--
I
E
L
G
------
K
------
G
P
--------
V
I
-
G
------
L
G
P
--------
V
----
V
D
R
N
L
V
Q
K
I
I
E
I
A
K
K
H
N
V
S
L
Q
E
E
A
-
V
----
G
G
R
----
T
D
F
V
Q
L
V
R
N
G
V
R
T
S
L
I
S
I
P
L
K
Y
M
H
T
P
V
E
M
V
D
P
R
D
V
E
E
L
A
R
L
L
S
L
V
A
V
E
L
E
-
4
PsiBlast_PDB
61.25
23%
-84
- C2 -
1VHE
1
YSDC_BACSU
A:
[5-306]
--
K
L
D
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
N
E
R
-
E
V
R
Q
V
M
K
S
Y
I
E
P
----
F
A
D
E
V
-------------
T
T
D
-
R
L
G
-
S
L
I
A
K
K
T
G
A
E
-
N
G
P
K
I
M
I
A
G
-
H
L
D
E
V
G
F
M
V
T
Q
I
---
T
D
K
G
F
I
R
--
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
Q
R
V
T
I
V
----
T
K
K
G
-----------
E
I
---
T
G
V
I
G
S
K
P
P
H
I
L
------
S
P
E
A
R
K
--
K
S
V
------
E
I
K
D
M
F
I
D
I
G
A
S
S
R
E
E
--------------
A
L
E
W
G
V
L
P
G
D
-
M
I
V
--
P
H
F
E
F
--------
T
VMN
N
-
E
K
-
F
L
L
A
K
A
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
Q
N
T
D
--
H
P
N
I
V
Y
G
V
G
T
V
Q
E
E
V
G
L
R
G
A
K
T
A
A
H
T
----
I
Q
---------------------------
P
------
D
I
A
--
F
G
V
--
D
V
G
I
A
G
-
D
---
T
---------
P
------
G
I
S
E
------
K
------
E
A
QSKMGKGP
Q
I
-
I
------
V
Y
D
A
S
-----
M
V
----
S
H
K
G
L
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
-
I
----
A
-
G
G
G
T
D
S
G
A
------------------------------------------------
2
PsiBlast_PDB
60.22
26%
-94
- C2 -
4WWV
-
?
A:
[10-321]
-------
I
E
L
I
K
K
L
T
S
L
H
A
P
S
G
R
E
D
-
P
V
K
D
L
V
A
E
L
M
K
S
----
H
V
D
K
L
-------------
W
I
D
-
V
W
G
-
N
V
V
G
Y
R
K
G
S
K
-
G
S
G
K
I
M
I
A
A
-
H
M
D
E
I
G
L
F
I
S
H
I
---
E
D
D
G
F
L
R
--
V
I
P
I
G
G
V
L
E
R
T
L
L
Y
Q
R
V
V
V
R
----
T
R
D
G
-----------
R
L
Y
R
G
V
I
G
L
K
P
P
--
H
V
I
------
E
A
Q
K
V
P
--
E
L
R
------
E
L
F
---
I
D
V
G
A
S
S
K
E
E
--------------
V
E
K
M
G
I
R
V
G
D
-
I
A
V
F
D
R
E
V
A
E
--------
L
---
G
-
W
N
-
R
I
T
S
K
A
F
D
D
R
V
G
V
V
V
M
L
K
A
L
E
M
L
E
K
H
D
V
D
V
----
Y
L
V
A
T
V
Q
E
E
V
G
L
K
G
A
K
----
T
S
A
Y
G
I
S
---------------------------
P
------
D
V
A
--
L
A
I
--
D
V
T
I
A
S
-
D
VP-
G
---------
V
------
A
K
S
E
WFTRLG
Y
------
G
P
--------
A
I
-
K
------
I
V
D
G
R
-----
N
A
GGLI
A
H
P
K
V
G
E
F
L
V
S
I
A
E
K
K
R
I
P
Y
Q
L
D
V
-
I
----
S
-
G
G
T
T
D
A
S
T
I
A
L
N
K
E
G
V
A
A
G
T
I
-----------------------------------
38
HHSearch
59.53
22%
-87
- C2 -
3CPX
10
?
A:
[15-321]
--
L
Y
F
Q
G
M
Q
L
L
K
E
L
C
S
I
H
A
P
S
G
N
E
E
-
P
L
K
D
F
I
L
E
Y
I
R
S
N
A
GS
W
S
Y
Q
P
V
I
-----------
Y
A
D
N
D
L
Q
-
D
C
I
V
L
V
F
G
----
N
P
R
T
A
V
F
A
-
H
M
D
S
I
G
F
T
V
S
Y
N
---
N
-----
H
--
L
H
P
I
G
S
P
S
A
--
K
E
G
Y
R
L
V
G
K
----
D
S
N
G
------------
D
I
E
G
V
L
K
I
V
--
D
E
-------------------------------------
E
W
M
L
E
--------------
T
-
D
R
L
I
D
R
G
T
-
E
V
T
F
K
P
D
F
R
E
------------
E
-
G
D
-
F
I
L
T
P
Y
L
D
D
R
L
G
V
W
T
A
L
E
L
A
K
T
L
E
H
--------
G
I
I
A
F
T
C
W
E
E
H
G
G
G
S
V
A
----
Y
----
L
A
---------------------------
R
W
I
Y
E
T
F
H
V
K
Q
S
L
I
C
--
D
I
T
W
V
T
-
E
---
G
----------------
V
E
A
G
------
K
------
G
V
--------
A
I
-
S
------
M
R
D
R
------
M
I
----
P
R
K
K
Y
V
N
R
I
I
E
L
A
R
Q
T
D
I
P
F
Q
L
E
V
-
E
----
G
-
A
G
A
S
D
G
R
E
L
Q
L
S
P
Y
P
W
D
W
C
F
I
G
A
P
E
K
D
A
H
T
P
N
E
C
V
H
K
K
D
I
E
S
M
V
G
L
Y
K
Y
L
M
E
K
L
--
8
PsiBlast_PDB
59.26
23%
-80
- C2 -
5DS0
3
?
A:
[5-302]
-----
K
S
M
E
L
M
K
T
L
M
E
A
F
G
P
S
G
F
E
R
-
E
V
N
A
I
C
K
E
Y
M
E
P
----
Y
A
D
E
V
-------------
V
V
D
-
K
L
G
-
S
V
T
F
I
A
K
G
N
D
---
R
P
R
I
L
M
A
G
H
T
D
E
V
G
F
I
V
S
S
I
---
S
K
E
G
Y
L
T
--
F
N
T
L
G
G
W
W
S
Q
V
L
L
G
Q
R
V
V
V
R
----
T
C
K
G
-----------
M
V
H
G
---
I
I
A
S
K
P
P
H
I
L
P
-----
P
D
E
R
K
K
IV
E
A
R
------
D
M
F
---
I
D
I
G
A
T
S
E
E
E
--------------
A
E
E
S
G
V
K
V
G
D
P
I
V
P
W
S
P
F
S
V
I
--------
Q
---
N
-
G
R
-
V
A
M
G
K
A
F
D
D
R
I
G
A
F
V
L
M
E
A
I
R
R
M
K
D
Q
G
I
E
H
P
N
T
V
Y
G
S
A
T
V
Q
E
E
V
G
L
R
G
A
Q
----
T
T
A
H
V
V
D
---------------------------
P
------
D
V
A
L
V
L
E
V
--
D
I
A
G
D
V
-
P
--------------------
K
P
H
E
------
A
LTKMGK
G
P
--------
G
L
-
V
------
T
Y
D
R
S
-----
M
I
----
P
N
Q
P
L
K
E
F
V
I
N
V
A
K
Q
A
Q
I
P
L
Q
L
S
Q
-
M
----
S
-
G
G
G
T
D
A
--------------------------------------------------
32
HHSearch
57.38
18%
-82
- C2 -
2GLF
2
APEA_THEMA
A:
[13-450]
---
K
E
E
I
E
A
F
S
K
E
Y
M
E
F
M
S
K
A
K
T
E
R
-
M
T
V
K
E
I
K
R
I
L
D
E
----
S
G
F
V
P
LEDFAGDPMNMT
V
Y
A
V
-
N
R
G
K
A
I
A
A
F
R
V
V
D
D
L
K
R
G
L
N
L
V
V
A
-
H
I
D
S
P
R
L
D
F
K
P
N
P
L
I
E
D
E
Q
I
A
L
F
K
T
H
Y
Y
G
G
I
K
K
Y
H
W
L
S
I
P
L
E
I
H
G
V
L
F
K
N
D
G
T
E
I
E
I
H
I
GDKP
E
D
P
V
F
T
I
P
D
L
--
L
P
H
L
D
K
E
D
A
KI
S
E
K
F
K
G
--
E
N
--------
L
M
---
L
I
A
G
T
I
P
L
S
G
EEKE
A
V
K
T
N
V
L
K
I
L
N
E
M
Y
G
I
T
E
E
D
-
F
V
S
G
E
I
E
V
V
P
AF
S
P
R
E
V
G
M
---
D
-
R
S
-
L
I
G
A
Y
G
Q
D
D
R
I
C
A
Y
T
A
L
R
A
L
L
S
A
N
-----
P
E
K
S
I
G
V
I
F
F
D
K
E
E
I
G
S
D
G
N
T
----
G
----
A
K
AR
F
Y
L
K
A
L
R
Q
I
L
K
M
Q
GAKD
S
E
F
V
L
D
E
V
L
------
E
N
T
S
V
I
S
G
--
D
V
C
A
A
V
N
P
---
P
YKDVHDLHN
A
------
P
K
L
G
------
Y
------
G
V
--------
A
L
V
K
------
Y
T
G
A
R
GKYS
T
N
D
----
A
H
A
E
F
V
A
R
V
R
K
V
L
N
E
Q
G
V
I
W
Q
V
A
T
L
G
KVDQ
G
-
G
G
G
T
I
A
K
F
F
--
A
E
R
G
S
D
V
I
D
M
G
P
A
L
L
G
M
H
S
P
F
E
I
S
S
K
A
D
L
F
E
T
Y
V
A
Y
R
S
L
M
E
K
L
--
11
PsiBlast_PDB
57.28
23%
-95
- C2 -
3ISX
3
?
A:
[15-296]
--------
E
L
I
R
K
L
T
E
A
F
G
P
S
G
R
E
E
-
E
V
R
S
I
I
L
E
E
L
-
E
----
G
H
I
D
G
-------------
H
R
I
-
D
G
L
-
G
N
L
I
V
W
K
G
-
S
-
G
E
K
K
V
I
L
D
A
-
H
I
D
E
I
G
V
V
V
T
N
V
---
D
D
K
G
F
L
T
--
I
E
P
V
G
G
V
S
P
Y
M
L
L
G
K
R
I
R
F
E
----------------------
N
G
T
I
G
V
------
V
G
M
E
G
E
--
T
T
E
E
R
Q
--
E
N
V
R
K
LSFD
K
L
F
---
I
D
I
G
A
N
S
R
E
E
--------------
A
Q
K
M
-
C
P
I
G
S
-
F
G
V
Y
D
S
G
F
-
V
--------
E
---
V
-
S
G
-
K
Y
V
S
K
A
M
D
D
R
I
G
C
A
V
I
V
E
V
F
K
R
I
K
P
-----
A
V
T
L
Y
G
V
F
S
V
Q
E
E
V
G
L
V
G
A
S
VAGY
G
----
V
P
---------------------------
A
------
D
--
E
A
I
A
I
--
D
V
T
D
S
A
-
D
---
T
P--------
K
------
A
I
K
R
------
H
------
A
M
--------
R
L
-
S
G
G
P
A
L
K
V
K
D
R
A
-----
S
I
----
S
S
K
R
I
L
E
N
L
I
E
I
A
E
K
F
D
I
K
Y
Q
M
E
V
-
L
----
T
-
F
G
G
T
N
A
--------------------------------------------------
15
PsiBlast_PDB
57.14
23%
-96
- C2 -
2CF4
2
?
A:
[5-289]
-------
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
-
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
-------------
I
-----
G
-
N
L
I
V
E
L
-
G
E
G
-
E
E
R
-
I
L
F
M
A
-
H
M
D
E
I
G
L
L
I
T
G
I
---
T
D
E
G
K
L
R
--
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
----
T
E
K
G
------------
I
L
D
G
V
I
--
G
A
T
P
P
H
L
-------
S
L
E
R
D
K
--
S
V
I
PWY---
D
L
V
---
I
D
I
G
A
E
S
K
E
E
--------------
A
L
E
L
-
V
K
P
L
D
-
F
A
V
F
K
K
H
F
S
V
--------
L
---
N
-
G
K
-
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
--
D
H
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
----
F
----
L
A
NHYY-----------------------
P
------
Q
Y
A
--
F
A
I
--
D
S
F
A
C
C
-
S
PLT
G
---------
D
------
V
K
L
G
------
K
------
G
P
--------
V
I
-
R
------
A
V
D
N
S
-----
A
I
----
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
-
T
----
G
--
G
G
T
D
A
S
A
------------------------------------------------
14
PsiBlast_PDB
55.92
23%
-94
- C2 -
2WYR
2
?
A:
[5-289]
-------
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
-
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
-------------
I
-----
G
-
N
L
I
V
E
L
-
G
E
G
-
E
E
R
-
I
L
F
M
A
-
H
M
D
E
I
G
L
L
I
T
G
I
---
T
D
E
G
K
L
R
--
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
----
T
E
K
G
------------
I
L
D
G
V
I
--
G
A
T
P
P
H
L
------------
K
--
S
V
I
P
WY---
D
L
V
---
I
D
I
G
A
E
S
K
E
E
--------------
A
L
E
L
-
V
K
P
L
D
-
F
A
V
F
K
K
H
F
S
V
--------
L
---
N
-
G
K
-
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
--
D
H
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
----
F
----
L
A
N
H
Y
Y-----------------------
P
------
Q
Y
A
--
F
A
I
--
D
S
F
A
C
C
-
S
PLT
G
---------
D
------
V
K
L
G
------
K
------
G
P
--------
V
I
-
R
------
A
V
D
N
S
-----
A
I
----
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
-
T
----
G
--
G
G
T
D
A
S
A
------------------------------------------------