@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu13130: (2016-06-20 )
MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFLLAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKENGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSVIYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVPVLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELLDQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQYGTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHARGPMGLPALTSTKYIIKGTGQIRE
Atome Classification :
(20 SA)
-----------------------------------------------------------.........10...-..--...20....--....30........40.....------...50........60........70-----......-..80........90-.-.......100.......110.......120...-.-.-.--...130..-.....140.......150.......160.-...----.----..170.......180......-.190.......200-...---......210..---------.....220..-.....230.......240.......---250.-----------.......260.......270......------------------------------------.280...---------------.------.-----.-----------------------------.---------------.290------.---.------.----------------------------.------..-------------...---300---......---------------------------------...-------310.......320--.......330-...----.....340.......350..--.....360.......370--------.-.-..-....380.......390........400.......410...------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------MSE
V
S
V
K
A
K
L
A
K
E
A
-
A
A
--
E
M
I
M
K
TTAE--
K
D
E
A
L
S
L
I
A
N
G
L
R
K
E
L
D
F
L
L
A
------EN
A
K
D
I
VNGKENGL
T
P
D
I
I
D
R
LSL
D
-----
E
K
R
I
R
D
-
I
A
D
A
V
E
L
L
I
D
L
ADP-I-G
D
S
L
E
T
I
E
KEN
G
L
F
I
E
K
IRVP
L
G
V
V
G
M
I
--YEA-R-P-N--
V
T
V
D
A
A
T
L
-
C
L
KTG
N
A
V
V
L
RGSSSAIHSN
K
A
L
V
S
V
I
Y
R
-
A
L
E
----Q----SAL
P
I
H
A
V
Q
L
I
EDT
S
R
E
T
A
K
E
-
L
FTLNDG
L
D
V
L
I---PRG---
G
K
K
L
I
D
L
V
VRE---------STV
P
V
L
ETGA-G
N
C
H
I
F
IDETAK
P
Q
M
A
E
K
V
V
V
NAKT---QR-
P
-----------
S
V
C
N
A
I
E
S
L
L
I
H
K
A
W
A
R
Q
H
G
K
E
L
L
D
Q
------------------------------------
L
E
-NAG
V
---------------
E
------
I
-----R-----------------------------G---------------
D
E
--------
L
---
V
------
C
----------------------------
E
------LH-------------PSS---K-----QASKED---------------------------------W
E
T
-------
E
F
L
A
P
V
L
S
V
K
T
V
E
--
N
V
Q
E
A
V
K
H
I
--
Q
Q
Y----GTNHS
E
A
I
L
TENDK
N
A
V
Y
F
Q--TAV
D
A
A
A
VYHNASTRFT---------D-G-FE-FGYGAEIG
I
S
T
Q
K
L
HA-RGPMGLPALTS
T
K
Y
I
I
KGTGQIRE------
1
PsiBlast_PDB
95.40
47%
-92
- C- -
1O20
-
PROA_THEMA
A:
[7-415]
-----------------------------------------------------------------
K
A
K
K
V
R
E
A
-
W
D
--
V
L
R
N
A
T
T
R
E
--
K
N
K
A
I
K
K
I
A
E
K
L
D
E
R
R
K
E
I
L
E
------
A
N
R
I
D
V
E
K
A
R
E
R
G
V
K
E
S
L
V
D
R
L
A
L
N
-----
D
K
R
I
D
E
-
M
I
K
A
C
E
T
V
I
G
L
K
D
P
-
V
-
G
E
V
I
D
S
W
V
R
E
D
G
L
R
I
A
R
V
R
V
P
I
G
P
I
G
I
I
--
Y
E
S
-
R
-
P
-
N
--
V
T
V
E
T
T
I
L
-
A
L
K
S
G
N
T
I
L
L
R
G
G
S
D
A
L
N
S
N
K
A
I
V
S
A
I
R
E
-
A
L
K
----
E
----
T
E
I
P
E
S
S
V
E
F
I
E
N
T
D
R
S
L
V
L
E
-
M
I
R
L
R
E
Y
L
S
L
V
I
---
P
R
G
---
G
Y
G
L
I
S
F
V
R
D
N
---------
A
T
V
P
V
L
E
T
G
V
-
G
N
C
H
I
F
V
D
E
S
A
D
L
K
K
A
V
P
V
I
I
N
A
K
T
---
Q
R
-
P
-----------
G
T
C
N
A
A
E
K
L
L
V
H
E
K
I
A
K
E
F
L
P
V
I
V
E
E
------------------------------------
L
R
-
K
H
G
V
---------------
E
------
V
-----
R
-----------------------------
G
---------------
C
E
--------
K
---
T
------
R
----------------------------
E
------
I
V
-------------
P
D
V
---
V
-----
P
A
T
E
D
D
---------------------------------
W
P
T
-------
E
Y
L
D
L
I
I
A
I
K
V
V
K
--
N
V
D
E
A
I
E
H
I
--
K
K
Y
----
S
T
G
H
S
E
S
I
L
T
E
N
Y
S
N
A
K
K
F
V
--
S
E
I
D
A
A
A
V
Y
V
N
A
S
T
R
F
T
---------
D
-
G
-
G
Q
-
F
G
F
G
A
E
I
G
I
S
T
Q
R
F
H
A
-
R
G
P
V
G
L
R
E
L
T
T
Y
K
F
V
V
L
G
E
Y
H
V
R
E
------
43
Fugue
94.96
47%
-87
- C- -
1O20
-
PROA_THEMA
A:
[2-415]
------------------------------------------------------------
D
E
L
L
E
K
A
K
K
V
R
E
A
-
W
D
--
V
L
R
N
A
T
T
R
E
--
K
N
K
A
I
K
K
I
A
E
K
L
D
E
R
R
K
E
I
L
E
------
A
N
R
I
D
V
E
K
A
R
E
R
G
V
K
E
S
L
V
D
R
L
A
L
N
-----
D
K
R
I
D
E
M
I
-
K
A
C
E
T
V
I
G
L
K
D
P
-
V
-
G
E
V
I
D
S
W
V
R
E
D
G
L
R
I
A
R
V
R
V
P
I
G
P
I
G
I
I
--
Y
E
S
-
R
-
P
-
N
--
V
T
V
E
T
T
I
L
-
A
L
K
S
G
N
T
I
L
L
R
G
G
S
D
A
L
N
S
N
K
A
I
V
S
A
I
R
E
-
A
L
K
----
E
----
T
E
I
P
E
S
S
V
E
F
I
E
N
T
D
R
S
L
V
L
E
M
I
-
R
L
R
E
Y
L
S
L
V
I
---
P
R
G
---
G
Y
G
L
I
S
F
V
R
D
N
---------
A
T
V
P
V
L
E
T
G
V
-
G
N
C
H
I
F
V
D
E
S
A
D
L
K
K
A
V
P
V
I
I
N
A
K
T
---
Q
R
-
P
-----------
G
T
C
N
A
A
E
K
L
L
V
H
E
K
I
A
K
E
F
L
P
V
I
V
E
E
------------------------------------
L
R
-
K
H
G
V
---------------
E
------
V
-----
R
-----------------------------
G
---------------
C
E
--------
K
---
T
------
R
----------------------------
E
------
I
V
-------------
P
D
V
---
V
-----
P
A
T
E
D
D
---------------------------------
W
P
T
-------
E
Y
L
D
L
I
I
A
I
K
V
V
K
--
N
V
D
E
A
I
E
H
I
--
K
K
Y
----
S
T
G
H
S
E
S
I
L
T
E
N
Y
S
N
A
K
K
F
V
--
S
E
I
D
A
A
A
V
Y
V
N
A
S
T
R
F
T
---------
D
-
G
-
G
Q
-
F
G
F
G
A
E
I
G
I
S
T
Q
R
F
H
A
-
R
G
P
V
G
L
R
E
L
T
T
Y
K
F
V
V
L
G
E
Y
H
V
R
E
------
22
HHSearch
91.58
44%
-89
- C- -
1O20
-
PROA_THEMA
A:
[2-415]
------------------------------------------------------------
D
E
L
L
E
K
A
K
K
V
R
E
A
-
W
D
--
V
L
R
N
A
T
T
R
E
--
K
N
K
A
I
K
K
I
A
E
K
L
D
E
R
R
K
E
I
L
E
------
A
N
R
I
D
V
E
K
A
R
E
R
G
V
K
E
S
L
V
D
R
L
A
L
N
-----
D
K
R
I
D
E
-
M
I
K
A
C
E
T
V
I
G
L
K
D
P
-
V
-
G
E
V
I
D
S
W
V
R
E
D
G
L
R
I
A
R
V
R
V
P
I
G
P
I
G
I
I
--
Y
E
S
-
R
-
P
-
N
--
V
T
V
E
T
T
I
L
-
A
L
K
S
G
N
T
I
L
L
R
G
G
S
D
A
L
N
S
N
K
A
I
V
S
A
I
R
E
-
A
L
K
----
E
----
T
E
I
P
E
S
S
V
E
F
I
E
N
T
D
R
S
L
V
L
E
-
M
I
R
L
R
E
Y
L
S
L
V
I
---
P
R
G
---
G
Y
G
L
I
S
F
V
R
D
N
---------
A
-
T
V
P
V
L
E
T
G
V
G
N
C
H
I
F
V
D
E
S
A
D
L
K
K
A
V
P
V
I
I
N
A
K
T
---
Q
R
-
P
-----------
G
T
C
N
A
A
E
K
L
L
V
H
E
K
I
A
K
E
F
L
P
V
I
V
E
E
------------------------------------
L
R
-
K
H
G
V
---------------
E
------
V
-----
R
-----------------------------
G
---------------
C
E
--------
K
---
T
------
R
----------------------------
E
------
I
V
-------------
P
D
V
---
V
-----
P
A
T
E
D
D
---------------------------------
W
P
T
-------
E
Y
L
D
L
I
I
A
I
K
V
V
K
--
N
V
D
E
A
I
E
H
I
--
K
K
Y
----
S
T
G
H
S
E
S
I
L
T
E
N
Y
S
N
A
K
K
F
V
--
S
E
I
D
A
A
A
V
Y
V
N
A
S
T
R
F
T
---------
D
-
G
G
Q
F
G
F
G
A
E
I
G
I
S
T
--
Q
R
F
H
A
-
R
G
P
V
G
L
R
E
L
T
T
Y
K
F
V
V
L
G
E
Y
H
V
R
E
------
23
HHSearch
89.05
42%
-98
- C- -
4GHK
-
PROA_BURTA
A:
[5-423]
------------------------------------------------------------
Q
Y
M
T
D
V
G
R
R
A
R
R
A
-
S
R
--
S
I
A
R
A
S
T
A
A
--
K
N
A
A
L
E
A
V
A
R
A
I
E
R
D
A
G
A
L
K
A
------
A
N
A
R
D
V
A
R
------
D
A
A
F
V
D
R
L
T
L
S
-----
D
K
A
L
K
T
-
M
V
E
G
L
R
Q
V
A
T
L
P
D
P
-
I
-
G
E
M
S
N
L
K
Y
R
P
S
G
I
Q
V
G
Q
M
R
V
P
L
G
V
I
G
I
I
--
Y
E
S
-
R
-
P
-
N
--
V
T
I
D
A
A
A
L
-
C
L
K
S
G
N
A
T
I
L
R
G
G
S
E
A
L
E
S
N
T
A
L
A
K
L
I
G
E
-
G
L
A
----
E
----
A
G
L
P
Q
D
T
V
Q
V
V
E
T
A
D
R
A
A
V
G
R
-
L
I
T
M
T
E
Y
V
D
V
I
V
---
P
R
G
---
G
K
S
L
I
E
R
L
I
N
E
---------
A
R
V
P
M
I
K
H
L
D
-
G
I
C
H
V
Y
V
D
D
R
A
S
V
T
K
A
L
T
V
C
D
------------------------
C
N
T
M
E
T
L
L
V
A
R
G
I
A
P
A
V
L
S
P
L
G
R
L
------------------------------------
Y
R
-
E
K
G
V
---------------
E
------
L
-----
R
-----------------------------
V
---------------
D
A
--------
D
---
A
------
R
----------------------------
A
V
L
E
A
A
G
V
G
-------------
P
L
----
V
-----
D
A
T
D
E
D
---------------------------------
W
R
T
-------
E
---
P
V
L
A
I
K
I
V
D
--
G
I
D
A
A
I
E
H
I
--
N
E
Y
----
G
S
H
H
T
D
A
I
V
T
E
D
H
D
R
A
M
R
F
L
--
R
E
V
D
S
A
S
V
M
V
N
A
S
T
R
F
A
---------
D
-
G
-
F
E
-
F
G
L
G
A
E
I
G
I
S
N
D
K
L
H
A
-
R
G
P
V
G
L
E
G
L
T
S
L
K
Y
V
V
L
G
H
G
E
G
R
Q
------
2
PsiBlast_PDB
88.95
42%
-102
- C- -
4GHK
-
PROA_BURTA
A:
[26-423]
------------------------------------------------------------------------------------
T
A
A
--
K
N
A
A
L
E
A
V
A
R
A
I
E
R
D
A
G
A
L
K
A
------
A
N
A
R
D
V
A
R
------
D
A
A
F
V
D
R
L
T
L
S
-----
D
K
A
L
K
T
-
M
V
E
G
L
R
Q
V
A
T
L
P
D
P
-
I
-
G
E
M
S
N
L
K
Y
R
P
S
G
I
Q
V
G
Q
M
R
V
P
L
G
V
I
G
I
I
--
Y
E
S
-
R
-
P
-
N
--
V
T
I
D
A
A
A
L
-
C
L
K
S
G
N
A
T
I
L
R
G
G
S
E
A
L
E
S
N
T
A
L
A
K
L
I
G
E
-
G
L
A
----
E
----
A
G
L
P
Q
D
T
V
Q
V
V
E
T
A
D
R
A
A
V
G
R
-
L
I
T
M
T
E
Y
V
D
V
I
V
---
P
R
G
---
G
K
S
L
I
E
R
L
I
N
E
---------
A
R
V
P
M
I
K
H
L
D
-
G
I
C
H
V
Y
V
D
D
R
A
S
V
T
K
A
L
T
V
C
D
------------------------
C
N
T
M
E
T
L
L
V
A
R
G
I
A
P
A
V
L
S
P
L
G
R
L
------------------------------------
Y
R
-
E
K
G
V
---------------
E
------
L
-----
R
-----------------------------
V
---------------
D
A
--------
D
---
A
------
R
----------------------------
A
------
V
L
-------------
E
A
A
---
G
VGPLV
D
A
T
D
E
D
---------------------------------
W
R
T
-------
E
---
P
V
L
A
I
K
I
V
D
--
G
I
D
A
A
I
E
H
I
--
N
E
Y
----
G
S
H
H
T
D
A
I
V
T
E
D
H
D
R
A
M
R
F
L
--
R
E
V
D
S
A
S
V
M
V
N
A
S
T
R
F
A
---------
D
-
G
-
F
E
-
F
G
L
G
A
E
I
G
I
S
N
D
K
L
H
A
-
R
G
P
V
G
L
E
G
L
T
S
L
K
Y
V
V
L
G
H
G
E
G
R
Q
------
4
PsiBlast_PDB
78.71
32%
-90
- C2 -
4JBE
14
?
A:
[45-440]
------------------------------------------------------------------
A
R
A
A
K
S
A
-
A
P
--
S
L
S
G
A
P
D
T
A
--
I
D
A
A
L
E
S
M
A
D
R
L
L
A
H
R
D
A
V
L
A
------
A
N
A
E
D
I
A
K
A
E
A
G
G
M
S
A
G
L
L
D
R
L
T
I
T
-----
E
S
R
L
T
D
-
M
A
D
Q
L
R
L
L
A
G
A
P
H
P
---
Q
R
T
V
E
L
S
T
L
D
G
G
L
R
L
V
E
R
R
R
P
V
G
V
I
G
A
N
--
Y
E
A
-
R
-
P
-
N
--
V
T
V
D
V
A
S
Q
-
L
V
K
S
R
N
A
G
V
L
R
T
G
S
A
A
L
K
S
A
Q
R
L
L
E
V
V
I
R
P
A
L
T
----
D
----
S
G
I
D
A
N
V
V
Q
L
V
P
R
P
E
R
E
A
A
G
A
-
L
V
R
L
P
D
L
V
P
L
V
I
---
L
R
G
SG
E
S
T
R
A
L
A
L
E
A
A
Q
---------
H
G
V
R
T
L
A
H
A
D
-
G
G
G
V
L
Y
V
D
E
K
A
D
R
D
T
V
R
S
L
V
V
N
S
-
L
---
D
R
-
L
-----------
G
V
C
N
R
L
N
L
L
L
I
H
D
A
V
Y
E
E
F
W
P
V
V
S
E
A
------------------------------------
L
A
-
E
R
G
V
---------------
S
----------------------------------------------------------
P
S
--------
L
---
P
------
P
----------------------------
Y
------
D
H
-------------
P
I
G
---
Y
-----
E
W
A
L
-
D
---------------------------------
S
E
R
-------
E
A
---
T
V
T
V
A
R
V
D
--
G
V
A
E
A
V
R
I
A
--
N
E
E
----
T
S
G
L
A
A
G
I
A
T
E
D
A
R
A
A
E
E
F
F
--
D
G
Y
Q
G
T
G
V
F
W
N
A
P
T
R
L
L
---------
D
-
G
-
F
K
-
L
L
G
V
P
E
T
G
I
N
L
D
K
V
P
G
P
R
G
P
V
T
Y
P
D
L
Y
V
R
Q
Y
A
V
--------------
3
PsiBlast_PDB
72.18
33%
-96
- C2 -
1VLU
1
PROA_YEAST
A:
[18-443]
-------------------------------------------------------------------
Q
I
A
K
N
A
R
K
A
--
G
N
I
L
K
T
I
S
N
E
G
R
S
D
I
L
Y
K
I
H
D
A
L
K
A
N
A
H
A
I
E
E
------
A
N
K
I
D
L
A
V
A
K
E
T
G
L
A
D
S
L
L
K
R
L
D
L
F
KGD
K
F
E
V
M
L
Q
G
-
I
K
D
V
A
E
L
----
E
D
P
-
V
-
G
K
V
K
M
A
R
E
L
D
D
G
L
T
L
Y
Q
V
T
A
P
V
G
V
L
L
V
I
--
F
E
S
-
R
-
P
-
E
--
V
I
A
N
I
T
A
L
-
S
I
K
S
G
N
A
A
I
L
K
G
G
K
E
S
V
N
T
F
R
E
M
A
K
I
V
N
D
-
T
I
A
----
Q
F
Q
SE
T
G
V
P
V
G
S
V
Q
L
I
E
--
T
R
--
V
S
D
-
L
L
D
Q
D
E
Y
I
D
L
V
V
---
P
R
G
---
S
N
A
L
V
R
K
I
K
D
T
---------
T
K
I
P
V
L
G
H
A
D
-
G
I
C
S
I
Y
L
D
E
D
A
D
L
I
K
A
K
R
I
S
L
D
A
K
T
---
N
----------------
C
N
A
M
E
T
L
L
I
N
P
K
F
S
K
W
W
--
E
V
L
E
N
------------------------------------
L
T
L
E
G
G
V
---------------
T
------
I
-----
H
-----------------------------
A
T
K
D
L
K
T
A
Y
F
D
K
L
N
E
L
G
K
--------
L
---
T
------
E
----------------------------
A
------
I
Q
-------------
C
K
T
---
V
---------------------------------------------------------
S
L
D
L
A
A
K
F
V
T
--
S
T
E
S
A
I
Q
H
I
--
N
T
H
----
S
S
R
H
T
D
A
I
V
T
E
N
K
A
N
A
E
K
F
M
--
K
G
V
D
S
S
G
V
Y
W
N
A
S
T
R
F
A
---------
D
--------------------------
V
G
L
D
G
L
V
S
Y
Q
Y
Q
I
R
G
D
G
Q
V
--------
26
HHSearch
70.63
31%
-95
- C2 -
1VLU
1
PROA_YEAST
A:
[13-444]
-----------------------------------------------------------
M
S
S
S
Q
Q
I
A
K
N
A
R
K
A
-
G
N
--
I
L
K
T
I
S
N
E
G
--
R
S
D
I
L
Y
K
I
H
D
A
L
K
A
N
A
H
A
I
E
E
A
N
K
I
D
L
A
V
A
K
E
T
G
L
----
A
D
S
L
L
K
R
--
L
D
L
F
K----
G
D
K
F
E
V
-
M
L
Q
G
I
K
D
V
A
E
L
E
D
P
-
V
-
G
K
V
K
M
A
R
E
L
D
D
G
L
T
L
Y
Q
V
T
A
P
V
G
V
L
L
V
I
--
F
E
S
-
R
-
P
-
E
--
V
I
A
N
I
T
A
L
-
S
I
K
S
G
N
A
A
I
L
K
G
G
K
E
S
V
N
T
F
R
E
M
A
K
I
V
N
D
-
T
I
A
Q
F
Q
S
E
----
T
G
V
P
V
G
S
V
Q
L
I
E
T
-
R
---
V
S
D
-
L
L
D
Q
D
E
Y
I
D
L
V
V
---
P
R
G
---
S
N
A
L
V
R
K
I
K
D
T
---------
T
K
I
P
V
L
G
H
A
D
-
G
I
C
S
I
Y
L
D
E
D
A
D
L
I
K
A
K
-
R
I
S
L
D
A
K
---
T
N
---------------
C
N
A
M
E
T
L
L
I
N
P
K
F
-
S
K
W
W
E
V
L
E
N
L
------------------------------------
T
L
-
E
G
G
V
----------------------------
T
-----------------------------
I
---------------
H
A
--------
T
K
D
L
K
------
T
A
Y
F
D
K
L
N
E
L
GKLT
E
A
-------------
I
------
Q
C
-------------
K
T
V
-------------------------------------------------------------
S
L
D
L
A
A
K
F
V
T
--
S
T
E
S
A
I
Q
H
I
--
N
T
H
----
S
S
R
H
T
D
A
I
V
T
E
N
K
A
N
A
E
K
F
M
--
K
G
V
D
S
S
G
V
Y
W
N
A
S
T
R
F
A
---------
D
--------------------------
V
G
L
D
G
L
V
S
Y
Q
Y
Q
I
R
G
D
G
Q
V
A
-------
44
Fugue
68.79
21%
-69
- C2 -
3K9D
1
?
A:
[3-456]
---------------------------------------------------LED
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
-
Q
K
--
E
L
A
A
M
S
Q
Q
Q
--
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
------
M
A
H
E
E
T
G
F
G
I
-------------
W
Q
-----
D
K
V
I
K
N
-
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
----
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
--
I
P
S
-
T
-
N
-
P
T
S
T
V
I
Y
K
T
L
I
-
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
-
A
A
E
----
K
----
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
-
L
M
K
-
H
K
D
T
A
V
I
L
---
A
T
G
---
G
S
A
M
V
K
A
A
Y
S
----------
S
G
T
P
A
I
G
V
G
P
-
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
---
F
D
-
N
G----------
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
F
L
S
D
A
E
A
V
Q
L
G
K
F
I
L
RPNGSMNPAIVGKS
V
Q
H
I
A
N
-
L
A
G
L
---------------
T
------
V
-----
P
-----------------------------
A
---------------
D
A
R
V
------
L
---
I
------
A
----------------------------
E
------
E
T
-------------
K
V
G
---
A
--------
K
I
P
---------------------------------
Y
S
R
-------
E
K
L
A
P
I
L
A
F
Y
T
A
E
--
T
W
Q
E
A
C
E
L
S
--
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
D
K
E
I
I
R
E
F
A
--
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
GATTNLV
P
-
A
-
L
T
-
L
G
C
G
A
V
G
G
S
S
S
S
D
N
------
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
IR----
38
HHSearch
66.37
18%
-101
- C2 -
4PXN
1
?
A:
[73-515]
------------------------------------------------------------
H
D
Y
E
E
G
M
R
A
C
F
D
A
-
A
K
--
T
W
M
A
I
P
A
P
K
--
R
G
E
I
V
R
Q
I
G
D
A
L
R
A
K
L
H
H
L
G
R
------
L
V
S
L
E
M
G
K
----
I
L
P
E
G
I
-
G
E
------------
V
Q
E
-
I
I
D
M
C
D
Y
A
V
G
L
S
R
Q
-
L
N
G
S
I
I
P
S
E
--
R
P
N
H
M
M
M
E
V
W
N
P
L
G
V
V
G
V
I
--
T
A
F
-
N
F
P
C
A
--
V
L
G
W
N
A
C
I
-
A
L
V
C
G
N
C
V
V
W
K
G
A
P
T
T
P
L
I
T
I
A
M
T
K
I
V
A
S
-
V
L
E
----
K
----
N
N
L
P
G
A
I
F
T
S
F
C
G
-
G
-
T
E
I
G
Q
-
A
I
A
L
D
I
R
I
P
L
V
S
---
F
T
G
---
S
T
R
A
G
L
M
V
Q
Q
Q
V
S
A
------
R
F
G
K
C
L
L
E
L
S
-
G
N
N
A
I
I
V
M
D
D
A
D
I
Q
L
A
V
R
S
V
L
F
A
A
V
---
G
T
-
A
G----------
Q
R
C
T
T
C
R
R
L
I
L
H
E
N
I
Y
Q
T
F
L
D
Q
L
V
E
V
------------------------------------
Y
K
-
Q
V
R
I
---------------
G
DP----
L
EKGT-
L
-----------------------------
L
---------------
G
P
L
HT
P
A
S
K
E
N
---
F
------
L
K
G
I
Q
T
I
K
S
Q
GGKILFGG
S
A
I
E
S
EGN---
F
------
V
Q
-------------
P
T
I
V
E
-
I
-----
T
P
S
A
P
V
---------------------------------
V
K
E
-------
E
L
F
G
P
V
L
Y
V
M
K
F
Q
--
T
L
K
E
A
I
E
I
N
--
N
S
V
----
P
Q
G
L
S
S
S
I
F
T
K
R
P
D
I
I
F
K
W
L
GP
H
G
S
D
C
G
I
V
N
V
N
I
P
T
N
G
A
---------
E
-
I
-
G
G
A
F
G
G
E
K
A
T
G
G
--
G
--
R
E
-
A
G
S
D
S
W
K
Q
Y
M
R
R
A
T
C
T
I
N
Y
G
S
E
--------
28
HHSearch
65.75
16%
-72
- C2 -
3U4J
-
?
A:
[61-502]
------------------------------------------------------------
D
D
V
R
K
A
V
A
A
A
R
K
A
-
F
D
AG
P
W
P
R
M
S
G
A
E
--
R
S
R
L
M
F
K
V
A
D
L
I
L
A
R
Q
E
E
L
A
L
------
I
E
S
L
E
V
G
K
----
P
I
A
Q
A
R
-
G
E
I
G
F
C
-----
A
D
L
W
S
Y
-
A
A
G
Q
A
R
A
L
-------
E
-
G
Q
T
H
N
N
--
I
G
D
D
R
L
G
L
V
L
R
E
P
V
G
V
V
G
I
I
--
T
P
W
-
N
F
P
F
I
--
I
A
S
E
R
V
P
W
-
A
I
G
S
G
C
T
V
V
L
K
P
S
E
F
T
S
G
T
S
I
R
L
A
E
L
A
R
E
-
A
------------
G
I
P
D
G
V
F
N
V
V
T
G
-
Y
G
D
P
A
G
Q
-
V
L
A
E
D
P
N
V
D
M
V
A
---
F
T
G
---
S
V
R
V
G
T
K
L
G
E
I
A
A
R
------
T
V
K
R
V
G
L
E
L
G
-
G
K
G
P
Q
I
V
F
A
D
A
D
L
D
A
A
A
D
G
I
A
Y
G
V
Y
---
H
N
A
G
-----------
Q
C
C
I
S
G
S
R
L
L
V
Q
E
G
I
R
D
A
L
M
E
R
L
L
D
I
------------------------------------
S
R
-
K
V
A
F
---------------
G
DP----
L
NERT-
K
I
G
A
M
IS
E
A
H
A
E
K
V
H
S
Y
V
T
A
G
I
T
S
GAELLL
G
---------------
G
E
--------
R
---
I
------
G
REA
G
L
-----------------------
Y
------
Y
A
-------------
P
T
V
F
A
G
V
-----
T
P
D
M
S
I
---------------------------------
A
R
E
-------
E
I
F
G
P
V
L
S
T
L
T
F
K
--
T
A
D
E
A
V
A
L
A
--
N
A
T
----
E
F
G
L
S
A
S
V
W
S
T
N
L
E
T
A
L
Q
T
I
--
R
R
I
R
A
G
R
C
W
I
N
S
V
I
D
G
T
---------
P
-
E
-
L
P
-
I
G
G
Y
K
K
S
G
L
--
G
R
--
E
-
L
G
R
Y
G
F
D
E
Y
S
Q
F
K
G
V
H
V
T
L
G
R
P
A
-------
24
HHSearch
65.26
17%
-89
* C2 *
3HAZ
6
?
A:
[550-988]
------------------------------------------------------------
D
Q
A
H
A
A
V
A
A
A
R
A
G
-
F
A
--
G
W
S
R
T
P
A
G
I
--
R
A
A
A
L
E
Q
A
A
H
L
L
E
S
R
S
A
H
F
I
A
------
L
L
Q
R
E
G
G
K
----
T
L
D
D
A
L
S
-
E
------------
L
R
E
-
A
A
D
F
C
R
Y
Y
A
A
Q
G
R
K
L
F
-
G
S
E
T
A
M
-
P
G
P
T
G
E
S
N
A
L
T
M
R
G
R
G
V
F
V
A
I
--
S
P
W
-
N
F
P
L
A
--
I
F
L
G
Q
V
T
A
-
A
L
M
A
G
N
S
V
V
A
K
P
A
E
Q
T
P
R
I
A
R
E
A
V
A
L
L
H
E
-
A
------------
G
I
P
K
S
A
L
Y
L
V
T
G
-
D
G
-
R
I
G
A
-
A
L
T
A
H
P
D
I
A
G
V
V
---
F
T
G
---
S
T
E
V
A
R
S
I
N
R
A
L
A
A
KDG---
P
I
V
P
L
I
A
E
T
G
-
G
I
N
A
M
I
A
D
A
T
A
L
P
E
Q
V
A
D
D
V
V
T
S
A
F
---
R
S
A
G
-----------
Q
R
C
S
A
L
R
L
L
F
V
Q
E
D
V
A
D
R
M
I
E
M
V
A
G
A
------------------------------------
A
R
-
E
L
K
I
---------------
G
DPSDVA
T
-----
H
-----------------------------
V
---------------
G
P
V
ID
V
E
A
K
Q
R
---
L
------
D
A
H
I
A
R
M
K
T
E
ARLH
F
A
G
P
A
P
EGC------
F
------
V
A
-------------
P
H
I
---
F
E
----
L
T
E
A
G
Q
---------------------------------
L
T
E
-------
E
V
F
G
P
I
L
H
V
V
R
Y
R
PE
N
L
E
R
V
L
R
A
I
--
E
R
T
----
G
Y
G
L
T
L
G
V
H
S
R
I
D
D
S
I
E
A
I
I
--
D
R
V
Q
V
G
N
I
Y
V
N
R
N
M
I
G
A
---------
V
V
G
-
V
Q
P
F
G
G
N
G
L
S
G
T
G
--
P
-
K
A
-
G
G
P
H
Y
L
A
R
F
A
T
E
Q
T
V
T
I
N
T
A
----------
40
HHSearch
63.64
18%
-79
- C2 -
4PZ2
5
?
A:
[88-528]
------------------------------------------------------------
E
D
V
D
L
A
V
R
A
A
R
A
A
-
F
D
HG
E
W
P
R
M
S
G
S
E
--
R
G
R
I
M
A
R
L
A
D
L
V
E
E
H
A
G
E
L
A
A
------
L
E
S
L
D
A
G
K
----
H
P
A
V
T
R
A
V
D
V
G
N
A
-----
A
G
S
L
R
Y
-
F
A
G
A
A
D
K
I
-------
H
-
G
E
T
L
K
M
---
P
G
Q
F
Q
G
H
T
L
R
E
P
L
G
V
A
G
V
I
--
I
P
W
-
N
F
P
S
T
--
M
F
A
V
K
V
A
P
-
A
L
A
A
G
C
A
L
V
V
K
P
A
E
Q
T
P
L
S
A
L
Y
L
A
Q
L
A
K
Q
-
A
------------
G
V
P
D
G
V
I
N
V
V
P
G
-
F
G
P
T
A
G
A
-
A
L
A
S
H
M
D
V
D
M
V
S
---
F
T
G
---
S
T
E
V
G
R
L
I
M
K
A
S
A
E
S
-----
N
L
K
P
V
Y
L
E
L
G
-
G
K
S
P
L
I
V
F
D
D
A
D
L
D
M
A
V
E
L
A
V
G
A
S
F
---
F
N
K
G
-----------
E
A
C
V
A
A
S
R
V
Y
V
Q
E
R
V
Y
D
R
F
E
E
R
L
A
E
R
------------------------------------
M
R
-
S
W
V
V
---------------
G
DP----
F
SDPRA
D
-----------------------------
Q
---------------
G
P
QVD
K
A
Q
Y
E
R
---
V
------
L
S
Y
I
D
H
G
K
R
E
G
A
T
L
LTGG
R
P
C
A
PKGY---
Y
------
I
E
-------------
P
T
V
F
T
N
V
-----
K
E
D
M
I
I
---------------------------------
A
K
E
-------
E
I
F
G
P
V
M
C
L
M
K
F
K
--
T
V
E
E
A
I
A
R
A
--
N
D
T
----
R
Y
G
L
G
A
G
V
V
T
R
D
L
D
V
A
N
R
V
V
--
R
S
V
R
A
G
V
V
W
V
N
C
Y
F
A
M
G
---------
S
-
D
-
C
P
-
F
G
G
R
K
M
S
G
F
--
G
K
--
D
-
E
G
M
H
A
L
D
K
Y
L
A
V
K
S
V
V
T
P
L
-----------
41
HHSearch
63.59
18%
-67
- C2 -
4QF6
3
?
A:
[57-493]
------------------------------------------------------------
E
D
I
D
A
A
V
K
A
A
R
S
A
-
F
E
SG
P
W
A
E
M
T
T
A
E
--
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
------
L
E
A
L
D
N
G
K
----
P
Y
Q
V
A
L
D
D
D
I
S
A
T
-----
V
E
N
Y
R
Y
-
Y
A
G
W
T
T
K
I
I
--------
G
Q
T
I
P
I
---
S
K
D
Y
L
N
Y
T
R
H
E
P
V
G
V
V
G
Q
I
--
I
P
W
-
N
F
P
L
V
--
M
S
S
W
K
M
G
A
-
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
-
A
------------
G
F
P
N
G
V
V
N
F
V
P
G
-
F
G
P
E
A
G
A
-
A
I
V
N
H
H
D
I
D
K
V
A
---
F
T
G
---
S
T
V
T
G
K
Y
I
M
R
Q
S
A
E
------
M
I
K
H
V
T
L
E
L
G
-
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
---
Y
N
H
G
-----------
Q
N
C
S
A
G
S
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
------------------------------------
A
N
-
N
V
K
L
---------------
G
A
G----
M
EKET-
E
MGPLVS
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
GATVAA
G
---------------
G
E
--------
R
---
A
L
EKG--
Y
----------------------------
F
------
V
K
-------------
P
T
V
F
T
D
V
-----
T
D
D
M
T
I
---------------------------------
V
K
E
-------
E
I
F
G
P
V
V
V
V
L
P
F
D
--
S
T
E
E
V
I
E
R
A
--
N
N
S
----
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
--
N
K
L
K
A
G
T
V
W
I
N
D
Y
N
L
E
N
---------
A
-
A
-
A
P
-
F
G
G
Y
K
Q
S
G
I
--
G
R
--
E
-
L
G
S
Y
A
L
D
N
Y
T
E
V
K
S
V
W
V
N
I
-----------
34
HHSearch
62.71
18%
-77
- C2 -
3I44
1
?
A:
[63-496]
------------------------------------------------------------
R
D
A
D
K
A
I
N
A
A
K
K
A
-
F
Q
--
T
W
K
T
T
S
P
H
E
--
R
L
G
F
V
E
K
I
L
E
I
Y
E
K
R
S
S
D
M
A
K
------
T
I
S
M
E
M
G
A
----
P
I
D
M
A
L
N
A
Q
T
A
T
G
-----
S
S
H
I
R
N
-
F
I
K
A
Y
K
E
F
S
F
Q
E
A
L
-------
I
----
E
G
N
E
Q
A
I
L
H
Y
D
A
I
G
V
V
G
L
I
--
T
P
W
-
N
W
P
M
N
--
Q
V
T
L
K
V
I
P
-
A
L
L
A
G
C
T
M
V
L
K
P
S
E
I
A
P
L
S
A
M
L
F
A
E
I
L
D
E
-
A
------------
A
L
P
S
G
V
F
N
L
I
N
G
-
D
G
A
N
V
G
S
-
Y
L
S
A
H
P
D
L
E
M
I
S
---
F
T
G
---
S
T
R
A
G
K
D
I
S
K
N
A
SN------
T
L
K
R
V
C
L
E
L
G
-
G
K
G
A
N
I
I
F
A
D
A
D
I
D
A
L
Q
R
-
G
V
R
H
C
F
---
Y
N
S
G
-----------
Q
S
C
N
A
P
T
R
M
L
V
E
Q
A
I
Y
D
K
A
I
K
T
A
K
D
I
------------------------------------
A
E
-
K
T
Q
V
---------------
G
P
G----
H
QTGN-
H
-----------------------------
I
---------------
G
P
VVS
K
E
Q
Y
D
K
---
I
------
Q
D
L
I
Q
S
G
I
D
E
GATLVTGGTGLPMGMERGY
Y
------
V
R
-------------
P
T
V
F
A
D
V
-----
K
P
H
M
R
I
---------------------------------
F
R
E
-------
E
I
F
G
P
V
L
S
L
L
P
F
N
--
T
E
D
E
A
V
T
L
A
--
N
D
T
----
E
Y
G
L
T
N
Y
I
Q
S
Q
D
R
S
K
C
R
R
I
A
--
A
Q
V
R
S
G
M
V
E
V
N
G
H
E
L
P
----------
G
-
G
-
S
Y
-
F
G
G
V
K
F
S
G
R
--
A
R
--
E
-
G
G
L
W
G
I
K
E
F
L
D
T
K
A
I
S
Y
-------------
27
HHSearch
62.71
17%
-86
- C2 -
4NM9
10
?
A:
[547-990]
------------------------------------------------------------
T
E
V
G
D
A
I
A
A
A
K
A
A
-
F
P
--
A
W
R
D
T
D
P
R
T
--
R
A
E
Y
L
L
K
A
A
Q
A
A
R
K
R
L
F
E
L
S
A
------
W
Q
V
L
E
I
G
K
----
Q
W
D
Q
A
Y
A
-
D
------------
V
T
E
-
A
I
D
F
L
E
Y
Y
A
R
E
M
I
R
-
L
-
G
Q
P
Q
R
V
-
G
H
A
P
G
E
L
N
H
Y
F
Y
E
P
K
G
V
A
A
V
I
--
A
P
W
-
N
F
P
L
A
--
I
S
M
G
M
A
S
A
-
A
I
V
T
G
N
C
V
V
F
K
P
S
G
I
T
S
I
I
G
W
H
L
V
E
L
F
R
E
-
A
------------
G
L
P
E
G
V
F
N
F
T
P
G
-
R
G
S
V
M
G
D
-
Y
L
V
D
H
P
D
I
S
L
I
A
---
F
T
G
---
S
M
E
T
G
L
R
I
I
E
R
A
A
KVHPGQA
N
V
K
K
I
I
S
E
M
G
-
G
K
N
A
I
I
I
D
D
D
A
D
L
D
E
A
V
P
H
V
L
Y
S
A
F
---
G
F
Q
G
-----------
Q
K
C
S
A
C
S
R
V
I
V
L
D
A
V
Y
D
K
F
I
E
R
L
V
S
M
------------------------------------
A
K
-
A
T
K
V
---------------
G
PSEDPA
N
-----
Y
-----------------------------
M
---------------
G
A
VAD
D
K
A
M
K
S
---
I
------
K
E
Y
A
E
I
G
K
R
E
GHVL
Y
E
S
P
V
P
A
G
E------
G
YF----
V
P
-------------
M
T
I
I
G
G
I
-----
K
P
E
H
R
I
---------------------------------
A
Q
E
-------
E
I
F
G
P
V
L
A
V
M
R
A
K
--
D
F
D
Q
A
I
E
W
A
--
N
S
T
----
Q
F
A
L
T
G
G
I
F
S
R
S
P
E
H
L
A
K
A
R
--
R
E
F
R
V
G
N
L
Y
I
N
R
N
N
T
G
A
---------
L
V
E
-
R
Q
P
F
G
G
A
R
M
S
G
V
--
G
T
-
K
A
-
G
G
P
D
Y
L
L
H
F
M
D
P
R
V
V
T
E
N
T
M
----------
46
Fugue
61.29
17%
-95
- C2 -
1A4S
-
BADH_GADMC
A:
[1-503]
A
Q
L
V
D
S
MPSASTGSVVVTDDLNYWGG
R
R
I
K
S
K
DGAT
T
E
P
V
F
EPATGRVL
C
Q
M
V
P
C
G
A
E
E
V
D
Q
A
V
Q
S
A
Q
A
A
Y
L
------
K
W
S
K
M
A
G
I
E
--
R
S
R
V
M
L
E
A
A
R
I
I
R
E
R
R
D
N
I
A
K
------
L
E
V
I
N
N
--
G
K
---------
T
I
T
E
A
E
------
Y
D
I
D
A
-
A
W
Q
C
I
E
Y
Y
A
G
L
A
P
T
-
L
S
G
Q
H
I
Q
L
P
---
G
G
A
F
A
Y
T
R
R
E
P
L
G
V
C
A
G
I
L
A
W
N
Y
-
P
-
F
-
M
--
I
A
A
W
K
C
A
P
-
A
L
A
C
G
N
A
V
V
F
K
P
S
P
M
T
P
V
T
G
V
I
L
A
E
I
F
H
E
-
A
------------
G
V
P
V
G
L
V
N
V
V
Q
G
G
-
A
E
T
G
S
L
-
L
C
H
H
P
N
V
A
K
V
S
F
T
G
S
V
P
T
---
G
K
K
V
M
E
M
S
A
K
----------
T
V
K
H
V
T
L
E
L
G
-
G
K
S
P
L
L
I
F
K
D
C
E
L
E
N
A
V
R
G
A
L
M
A
N
F
---
L
T
-
Q
G----------
Q
V
C
T
N
G
T
R
V
F
V
Q
R
E
I
M
P
Q
F
L
E
E
V
V
K
R
------------------------------------
T
K
-
A
I
V
V
G
DPLLTETRMGGLIS
K
------
P
-----
Q
-----------------------------
L
---------------
D
K
--------
V
---
L
------
G
----------------------------
F
------
V
A
-------------
Q
A
K
---
K
-----
E
G
A
R
V
L
CGG
E
P
L
T
P
SDPKLKNGYFM
S
P
C
V
L
D
NCRDDMTC
V
K
E
-------
E
I
F
G
P
V
M
S
V
L
P
F
D
--
T
E
E
E
V
L
Q
R
A
--
N
N
T
----
T
F
G
L
A
S
G
V
F
T
R
D
I
S
R
A
H
R
V
A
--
A
N
L
E
A
G
T
C
Y
I
N
T
Y
S
I
-----------
S
-
P
-
V
E
-
V
P
F
G
G
Y
K
M
S
G
F
G
R
E
N
---
G
Q
A
T
V
D
Y
Y
S
Q
L
K
T
V
I
V
E
-
M
G
---DVDSLF
29
HHSearch
60.86
17%
-59
- C2 -
4QTO
8
?
A:
[70-510]
------------------------------------------------------------
E
D
A
E
R
A
I
L
A
A
R
R
A
-
F
E
S
G
E
W
S
Q
E
T
A
E
T
--
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
------
L
E
T
L
D
T
G
K
----
T
L
E
E
S
Y
A
-
D
------------
M
D
D
-
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
-
G
E
M
I
D
S
--
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
--
T
P
W
-
N
Y
P
L
L
--
Q
A
S
W
K
I
A
P
-
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
-
V
------------
G
F
P
K
G
T
I
N
L
I
L
G
-
A
G
S
E
V
G
D
-
V
M
S
G
H
K
E
V
D
L
V
S
---
F
T
G
---
G
I
E
T
G
K
H
I
M
K
N
A
A
N------
N
V
T
N
I
A
L
E
L
G
-
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
---
F
H
A
G
-----------
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
------------------------------------
V
K
-
K
I
K
L
---------------
G
NG----
F
DADT-
E
M
G
P
VI
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
EGATIAV
G
---------------
G
K
--------
R
---
P
DRDDLK
D
GL--------------------------
F
------
F
E
-------------
P
T
V
I
TN
C
-----
D
T
S
M
R
I
---------------------------------
V
Q
E
-------
E
V
F
G
P
V
V
T
V
E
G
F
E
--
T
E
Q
E
A
I
Q
L
A
--
N
D
S
----
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
--
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
---------
A
-
Q
-
A
P
-
W
G
G
Y
K
Q
S
G
I
--
G
R
--
E
-
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
-----------
35
HHSearch
60.75
19%
-70
- C2 -
3PRL
1
?
A:
[49-483]
------------------------------------------------------------
E
E
V
N
D
A
I
Q
G
A
K
D
A
-
Q
K
--
I
W
K
I
R
P
I
H
E
--
R
V
D
L
L
Y
A
W
A
D
L
L
E
E
R
K
E
I
I
G
E
------
L
I
M
H
E
V
A
K
P
K
----
K
S
A
I
-
G
E
V
S
R
T
-----
A
D
I
I
R
H
-
T
A
D
E
A
L
R
L
N
G
E
T
L
K
-
G
-
D
Q
F
K
---
G
G
S
S
K
K
I
A
L
V
E
R
E
P
L
G
V
V
L
A
I
--
S
P
F
-
N
Y
P
V
N
--
L
A
A
A
K
I
A
P
-
A
L
V
T
G
N
T
V
V
F
K
P
A
T
Q
G
S
L
S
G
I
K
M
V
E
A
L
A
D
-
A
------------
G
A
P
E
G
I
I
Q
V
V
T
G
-
R
G
S
V
I
G
D
-
H
L
V
E
H
P
G
I
D
M
I
T
---
F
T
G
---
G
T
T
T
G
E
R
I
S
E
K
A--------
K
M
I
P
V
V
L
E
L
G
-
G
K
D
P
A
I
V
L
D
D
A
D
L
K
L
T
A
S
Q
I
V
S
G
A
F
---
S
Y
S
G
-----------
Q
R
C
T
A
I
K
R
V
F
V
Q
D
S
V
A
D
Q
L
V
A
N
I
K
E
L
------------------------------------
V
E
-
Q
L
T
V
---------------
G
S
P----
E
DDA--
D
-----------------------------
I
---------------
T
P
VID
E
K
S
A
A
F
---
I
------
Q
G
L
I
D
D
A
L
E
N
G
A
T
L
LSGNKRQG-------
N
L-----
L
S
-------------
P
T
L
L
D
D
V
-----
T
P
A
M
R
V
---------------------------------
A
W
E
-------
E
P
F
G
P
V
L
P
I
I
R
V
K
--
D
A
N
E
A
I
S
L
S
--
N
Q
S
----
D
Y
G
L
Q
A
S
I
F
T
K
D
T
D
R
A
I
N
I
G
--
K
H
L
E
V
G
T
V
H
I
N
A
K
T
E
R
G
---------
P
-
D
-
H
F
P
F
L
G
V
K
K
S
G
L
--
G
V
--
Q
-
G
I
K
P
S
L
L
S
M
T
R
E
R
V
T
V
L
N
L
-----------
6
PsiBlast_PDB
60.41
21%
-88
- C2 -
4C3S
4
?
A:
[109-429]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
G
V
I
G
A
I
--
T
P
C
T
N
-
P
-
S
--
E
T
I
I
C
N
T
I
G
M
L
A
G
G
N
T
V
V
F
N
P
H
P
A
A
I
K
T
S
N
F
A
V
Q
L
I
N
E
-
A
S
L
----
S
----
A
G
G
P
V
N
I
A
C
S
V
R
K
P
T
L
D
S
S
K
I
-
M
M
S
H
Q
D
-
I
P
L
I
A
---
A
T
G
---
G
P
G
V
V
T
A
V
L
-
Q
---------
S
G
K
R
G
I
G
A
G
A
-
G
N
P
P
V
L
V
D
E
T
A
D
I
R
K
A
A
E
D
I
I
N
G
C
T
FDN
N
L
-
P
CIAEK
E
V
V
A
I
D
A
I
A
N
E
L
M
N
Y
M
V
K
E
Q
G
C
Y
A
I
T
K
E
Q
Q
E
K
------------------------------------
L
T
-
N
L
V
I
---------------
T
------
P
-----
K
-----------------------------
G
---------------
L
N
--------
R
---
N
------
C
----------------------------
V
------
G
K
D
A
R
T
L
L
G
M
I
G
I
D
V
P
S
N
---
I
-----
R
C
I
I
F
E
---------------------------------
G
E
K
EH
P
L
I
S
E
E
L
M
M
P
I
L
G
I
V
R
A
K
--
S
F
D
D
A
V
E
K
A
V
W
L
E
H
----
G
N
R
H
S
A
H
I
H
S
K
N
V
D
R
I
T
T
Y
A
--
K
A
I
D
T
A
I
L
V
K
N
A
P
S
Y
A
A
----------------
I
G
F
G
G
E
-
G
F
C
T
F
T
I
A
S
-
R
T
G
E
G
L
T
S
A
S
T
-------------------