@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu13420: (2016-06-21 )
MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIWLIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHILTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIFFDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHWSIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGDIISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFHLNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTKVLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARLGGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTDGLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQPQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQARIWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNHSKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQITGAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQPSQ
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.----......450.......460-.......-----..470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570...-....580.......590.......600.......610.......620....---...---630-.---..-.-.....-640.......650.......660...--....670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
I
H
V
T
YN
T
T
L
I
C
L
S
I
L
I
A
C
T
A
S
Y
I
S
L
E
L
S
R
K
V
T
INTGLK
S
K
I
W
L
IGG
S
L
I
M
G
F
G
I
W
S
M
H
F
V
G
M
M
A
V
H
MEMPMEY
E
F
M
P
L
M
A
A
IGASVSG
S
F
V
S
L
Y
F
V
S
R
H
I
L
T
Y
Y
R
L
LTG
S
V
V
L
G
A
S
I
A
S
M
H
Y
I
G
M
S
A
I
S
R
V
M
I
I
Y
E
P
I
L
F
T
V
S
I
I
I
A
I
A
A
S
F
V
S
L
K
I
F
F
D
L
A
VKKHSE
H
L
I
F
Y
K
G
V
S
S
I
V
M
G
IGISGMHYT
G
M
L
A
A
T
F
HKDMAPPGSH
M
E
V
Q
T
F
H
W
S
I
F
V
T
L
I
I
F
C
I
Q
T
L
L
L
FSSHA
D
R
K
F
I
K
Q
S
E
RIK
D
N
E
Q
R
F
Q
S
L
I
V
HNI
D
A
I
F
I
L
S
LEG
D
I
ISSNHA
G
E
E
M
I
S
K
FGFS
M
H
D
W
RN
Y
T
S
L
K
V
K
R
L
F
E
Q
V
K
K
D
K
Q
AMNSDSDLITEK
G
Q
F
H
L
N
I
T
L
I
P
V
EVNQEL
D
S
I
Y
V
I
C
K
D
M
T
K
Q
Y
K
A
E
K
E
I
H
R
M
AH
Y
D
S
L
TDLPN
R
R
H
A
I
S
H
L
T
K
V
LNREHS
L
H
Y
N
T
V
V
F
F
L
DL
N
R
F
K
V
I
N
D
A
LGH
N
V
G
D
Q
L
L
Q
F
A
A
K
R
L
S
S
VVPD----N
G
F
I
A
R
LGG
D
E
F
I
I
I
L
T
---DANTGT
G
-----
E
A
D
V
L
A
R
K
I
I
Q
K
F
KKPFKIQD
H
T
L
V
T
S
V
S
I
G
I
A
I
SPKDGT
D
G
L
E
L
M
K
K
A
D
M
A
M
Y
A
A
KERNKS
K
Y
R
Y
Y
S
F
SIGN
K
E
T
V
KL
N
Q
E
M
V
L
R
E
A
IEND
R
F
V
L
H
YQPQFS
V
K
K
QK-MT
G
A
E
A
L
I
R
L
VTPDGQLRPPG
E
F
I
GVAEET
G
L
I
I
D
I
G
K
W
I
I
D
E
A
C
K
Q
ARIW---HDK---G---Y---
D
L
-
S
-
V
A
I
N
I
-
S
ARQFQSKD
L
I
P
L
I
K
D
T
L
N
K
YQL
P
P
Q
--
L
L
E
V
E
VTESMTMDNL
N
H
S
K
K
V
L
S
S
L
T
EL
G
I
R
I
S
I
DDFGTGH
S
S
L
S
Y
L
K
DFPI
H
R
L
KI
D
K
S
F
I
D
D
I
QTHPKSEQ
I
T
G
A
I
IAMG
H
Q
L
S
L
Q
V
I
A
E
G
V
E
N
A
A
Q
K
Q
L
L
F
E
KGC
D
H
L
Q
G
F
F
FSRPI
P
P
E
Q
F
E
Q
F
I
IEQPSQ
56
HHSearch
83.45
45%
-132
- C2 -
4RNH
3
?
A:
[21-449]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
V
L
M
F
L
D
L
D
R
F
------
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
----
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
---
S
--
Q
G
D
R
E
I
A
L
K
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
---
H
K
A
---
K
V--
R
---
V
P
-
K
-
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
--
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
M
L
Y
A
-----
1
PsiBlast_PDB
83.06
45%
-136
- C2 -
4RNH
3
?
A:
[21-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
V
L
M
F
L
D
L
D
R
F
------
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
----
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
SQG
D
R
E
I
A
L
K
-----
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
---
H
K
A
---
K
---
V
---
R
V
P
K
-
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
--
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
----------
2
PsiBlast_PDB
80.62
45%
-134
- C2 -
4RNF
-
?
A:
[1-424]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
V
L
M
F
L
D
L
D
-----
N
D
S
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
----
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
SQG
D
R
E
I
A
L
K
-----
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
---
H
K
A
---
K
---
V
---
R
V
P
K
-
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
--
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
N
N
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
----------
3
PsiBlast_PDB
57.27
50%
-138
- C2 -
4RNI
-
?
A:
[4-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
---
H
K
A
---
K
---
V
---
R
V
-
P
K
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
--
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
----------
4
PsiBlast_PDB
55.92
50%
-135
- C2 -
4RNJ
-
?
A:
[4-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
---
H
K
A
---
K
---
V
---
R
V
-
P
K
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
--
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
----------
63
HHSearch
54.03
46%
-130
- C2 -
4RNI
-
?
A:
[4-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
-
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
---
H
K
A
---
K
V--
R
---
V
P
-
K
-
V
S
V
N
L
-
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
--
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
H
G
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
M
L
Y
A
S
----
15
PsiBlast_PDB
53.06
33%
-145
- C2 -
4Y9N
1
?
A:
[11-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
-
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
---
A
G
K
LEP
G
---
F
------
H
-
I
G
F
N
I
-
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
--
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
T
L
S
G
H
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
T
V
Q
E
G
Q
7
PsiBlast_PDB
52.93
36%
-144
- C2 -
4HU3
-
DOSP_ECOLI
A:
[531-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
M
N
E
M
V
K
E
R
L
V
L
G
A
A
L
K
E
A
I
S
N
N
Q
L
K
L
V
Y
Q
P
Q
I
F
A
E
T
G
E
-
L
Y
G
I
E
A
L
A
R
W
H
D
P
L
H
G
H
V
P
P
S
R
F
I
P
L
A
E
E
I
G
E
I
E
N
I
G
R
W
V
I
A
E
A
C
R
Q
L
A
E
W
---
R
S
Q
---
N
---
I
---
H
I
P
A
-
L
S
V
N
L
-
S
A
L
H
F
R
S
N
Q
L
P
N
Q
V
S
D
A
M
H
A
W
G
I
D
G
H
--
Q
L
T
V
E
I
T
E
S
M
M
M
E
H
D
T
E
I
F
K
R
I
Q
I
L
R
D
M
G
V
G
L
S
V
D
D
F
G
T
G
F
S
G
L
S
R
L
V
S
L
P
V
T
E
I
K
I
D
K
S
F
V
D
R
C
L
T
E
K
R
I
L
A
L
L
E
A
I
T
S
I
G
Q
S
L
N
L
T
V
V
A
E
G
V
E
T
K
E
Q
F
E
M
L
R
K
I
H
C
R
V
I
Q
G
Y
F
F
S
R
P
L
P
A
E
E
I
P
G
W
M
------
58
HHSearch
52.85
22%
-104
- C3 -
3PJX
9
?
A:
[8-429]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
S
E
K
L
R
T
E
S
Y
Q
D
N
L
T
G
L
A
N
R
R
Y
F
E
M
Q
L
N
A
R
V
S
N
P
E
-
Q
A
S
S
G
Y
L
L
L
L
R
V
K
D
L
A
G
L
N
Q
R
L
G
G
Q
R
T
D
E
L
L
K
A
V
G
E
Q
L
S
R
E
C
A
K
YPET
Q
N
L
V
T
R
I
R
G
G
E
F
A
V
L
A
P
---
G
--
M
T
R
E
-----
E
A
L
Q
L
A
Q
S
L
D
S
A
L
S
S
L
Y
A
T
G
A
T
D
V
A
A
V
A
S
I
G
L
A
P
F
A
-
H
G
D
S
P
Q
A
V
L
S
L
G
D
Q
A
L
A
Q
A
E
G
Q
G
E
Q
N
W
A
C
L
D
------
G
D
D
H
H
A
W
H
R
L
L
D
Q
A
L
N
Q
R
R
F
E
L
F
F
Q
P
V
V
A
A
Q
D
T
Q
L
V
L
H
Y
K
V
L
S
R
L
L
D
E
Q
G
Q
T
I
P
A
G
R
F
L
P
W
L
E
R
F
G
W
T
A
R
L
D
R
L
M
L
E
R
V
L
E
Q
M
A
G
H
-----------------
E
E
-
S
-
L
A
L
N
L
-
S
S
A
T
L
A
D
P
Q
A
L
N
K
V
F
E
I
L
R
A
H
S
N
L
G
A
--
R
L
T
L
E
I
G
E
E
Q
L
P
E
Q
-
A
V
L
E
Q
L
T
R
R
L
R
E
L
G
F
S
L
S
L
Q
R
F
G
G
R
F
S
M
I
G
N
L
A
R
L
G
L
A
Y
L
K
I
D
G
S
Y
I
R
A
I
D
Q
E
S
D
K
R
L
F
I
E
A
I
Q
R
A
A
H
S
I
D
L
P
L
I
A
E
R
V
E
T
E
G
E
L
S
V
I
R
E
M
G
L
Y
G
V
Q
G
Q
L
F
G
E
P
K
P
W
-------------
9
PsiBlast_PDB
52.76
33%
-124
- C2 -
4HJF
3
?
A:
[73-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
A
L
E
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
-
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
P
A
---
M
---
G
---
N
L
-
T
-
V
S
V
N
L
-
S
T
G
E
I
D
R
P
G
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
--
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
G
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
A
E
V
Y
L
N
E
----
14
PsiBlast_PDB
51.97
33%
-142
- C2 -
4Y9M
1
?
A:
[11-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
-
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
---
A
G
K
LEP
G
---
F
------
H
-
I
G
F
N
I
-
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
--
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
T
L
S
G
H
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
T
V
Q
E
G
Q
23
PsiBlast_CBE
51.69
38%
-162
- C3 -
4URS
7
?
B:
[27-188]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
H
D
P
L
T
G
L
P
N
R
R
Y
F
F
E
L
G
N
R
Y
L
D
L
A
K
R
E
G
K
K
V
F
V
L
F
V
D
L
A
G
F
K
A
I
N
D
T
Y
G
H
L
S
G
D
E
V
L
K
T
V
S
K
R
I
L
D
R
V
R
R
----
S
D
V
V
A
R
Y
G
G
D
E
F
T
I
L
L
Y
---
D
M
K
E
E
Y
L
-----
K
S
--
L
L
E
R
I
L
S
T
F
R
E
P
V
R
V
E
N
K
H
L
S
V
T
P
N
I
G
V
A
R
F
P
E
D
G
E
N
L
E
E
L
L
K
V
A
D
M
R
M
Y
K
A
K
E
M
---
K
V
P
Y
F
S
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
51.19
37%
-166
- C3 -
4URG
2
?
A:
[1-150]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
P
L
T
G
L
P
N
R
R
Y
F
F
E
L
G
N
R
Y
L
D
L
A
K
R
E
G
K
K
V
F
V
L
F
V
D
L
A
G
F
K
A
I
N
D
T
Y
G
H
L
S
G
D
E
V
L
K
T
V
S
K
R
I
L
D
R
V
R
R
----
S
D
V
V
A
R
Y
G
G
D
E
F
T
I
L
L
Y
---
D
M
K
E
E
Y
L
-----
K
S
--
L
L
E
R
I
L
S
T
F
R
E
P
V
R
V
E
N
K
H
L
S
V
T
P
N
I
G
V
A
R
F
P
E
D
G
E
N
L
E
E
L
L
K
V
A
D
M
R
M
Y
K
A
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
51.17
32%
-137
- C2 -
4Y9M
1
?
A:
[5-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
-
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
---
A
G
K
---
L
E--
P
---
G
F
-
H
-
I
G
F
N
I
-
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
--
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
T
L
S
G
H
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
T
V
Q
E
G
Q
6
PsiBlast_PDB
51.10
38%
-123
- C2 -
3N3T
4
?
A:
[24-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
T
L
D
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
-
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
E
A
C
C
T
Q
L
R
A
W
---
Q
Q
Q
---
G
---
R
AAD
D
L
-
T
-
L
S
V
N
I
-
S
T
R
Q
F
E
G
E
H
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
--
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
Q
A
A
D
A
F
A
S
L
L
D
R
Q
---
60
HHSearch
51.03
31%
-119
* C2 *
4HJF
3
?
A:
[70-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
R
L
A
L
E
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
-
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
H
A
A
A
Q
Q
L
S
T
W
---
R
A
A
---
H
PAM
G
---
N
L
-
T
-
V
S
V
N
L
-
S
T
G
E
I
D
R
P
G
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
--
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
G
T
G
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
A
E
V
Y
L
N
E
A
Y
V
-
5
PsiBlast_PDB
50.40
38%
-122
- C2 -
2R6O
4
?
A:
[24-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
T
L
D
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
-
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
E
A
C
C
T
Q
L
R
A
W
---
Q
Q
Q
---
G
---
R
AAD
D
L
-
T
-
L
S
V
N
I
-
S
T
R
Q
F
E
G
E
H
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
--
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
Q
A
A
D
A
F
A
S
L
L
D
R
Q
---
24
PsiBlast_CBE
50.39
38%
-155
- C3 -
4URS
6
?
A:
[27-188]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
H
D
P
L
T
G
L
P
N
R
R
Y
F
F
E
L
G
N
R
Y
L
D
L
A
K
R
E
G
K
K
V
F
V
L
F
V
D
L
A
G
F
K
A
I
N
D
T
Y
G
H
L
S
G
D
E
V
L
K
T
V
S
K
R
I
L
D
R
V
R
R
----
S
D
V
V
A
R
Y
G
G
D
E
F
T
I
L
L
Y
---
D
M
K
E
E
Y
L
-----
K
S
--
L
L
E
R
I
L
S
T
F
R
E
P
V
R
V
E
N
K
H
L
S
V
T
P
N
I
G
V
A
R
F
P
E
D
G
E
N
L
E
E
L
L
K
V
A
D
M
R
M
Y
K
A
K
E
M
---
K
V
P
Y
F
S
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
49.90
36%
-122
- C2 -
2R6O
4
?
A:
[24-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
T
L
D
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
-
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
E
A
C
C
T
Q
L
R
A
W
---
Q
Q
Q
---
G
RAA
D
---
D
L
-
T
-
L
S
V
N
I
-
S
T
R
Q
F
E
G
E
H
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
--
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
A
H
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
Q
A
A
D
A
F
A
S
L
L
D
R
Q
---
11
PsiBlast_PDB
48.99
33%
-123
- C2 -
3S83
2
?
A:
[1-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
E
A
D
L
R
G
A
I
G
R
G
E
I
T
P
Y
F
Q
P
I
V
R
L
S
T
G
A
-
L
S
G
F
E
A
L
A
R
W
I
H
P
R
R
G
M
L
P
P
D
E
F
L
P
L
I
E
E
M
G
L
M
S
E
L
G
A
H
M
M
H
A
A
A
Q
Q
L
S
T
W
R
A
A
H
P
A
---
M
---
G
---
N
L
-
T
-
V
S
V
N
L
-
S
T
G
E
I
D
R
P
G
L
V
A
D
V
A
E
T
L
R
V
N
R
L
P
R
G
--
A
L
K
L
E
V
T
E
S
D
I
M
R
D
P
E
R
A
A
V
I
L
K
T
L
R
D
A
G
A
G
L
A
L
D
D
F
---
F
S
S
L
S
Y
L
T
R
L
P
F
D
T
L
K
I
D
R
Y
F
V
R
T
M
G
N
N
A
G
S
A
K
I
V
R
S
V
V
K
L
G
Q
D
L
D
L
E
V
V
A
E
G
V
E
N
A
E
M
A
H
A
L
Q
S
L
G
C
D
Y
G
Q
G
F
G
Y
A
P
A
L
S
P
Q
E
A
E
V
Y
L
N
E
----
33
PsiBlast_CBE
42.35
32%
-170
- C2 -
3GFY
1
?
B:
[244-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
N
L
L
P
G
S
L
Y
H
H
P
D
A
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
--
Q
V
L
I
E
V
-------
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
-------------
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
---------------
29
PsiBlast_CBE
36.76
32%
-139
- C2 -
3GG0
3
?
B:
[244-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
N
L
L
P
G
S
L
Y
H
H
P
D
A
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
--
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
---------------
35
PsiBlast_CBE
36.27
32%
-132
- C2 -
3GFX
2
?
B:
[244-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
N
L
L
P
G
S
L
Y
H
H
P
D
A
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
--
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
---------------
27
PsiBlast_CBE
36.06
32%
-137
- C2 -
3GG1
3
?
B:
[244-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
N
L
L
P
G
S
L
Y
H
H
P
D
A
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
--
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
---------------
31
PsiBlast_CBE
35.82
32%
-133
- C2 -
3GFZ
3
?
B:
[244-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
I
N
L
L
P
G
S
L
Y
H
H
P
D
A
V
G
W
L
M
D
S
L
L
A
A
G
L
R
P
D
--
Q
V
L
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
G
T
K
Q
A
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
C
---------------