@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14450: (2016-06-22 )
MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIVKHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVVSSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGKSEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTDLTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNIIENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFYNTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDGITADGKREPIFRNGNWAF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70......--.--.80........90........-100.......110.......120.......130.......140.......150......-.160-.......170.......180.......190.......-200.......210.......220.......230...-.-..--..-240.......250.......260.......270.......280.......290.......300.......310.......320-........330..----..--...340.......350.......360.......370.......380...-....390.......400.......410-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
S
F
S
Q
K
L
N
T
Y
A
Q
L
A
V
E
VG
V
N
VQKG
Q
Y
V
V
V
NAST
D
V
R
D
F
V
R
L
I
V
K
H
A
Y
EKGAK
N
V
T
V
NWQDD
E
V
A
K
L
K
Y
ELA
P
F
E
A
F
--
E
--EYPEWEAK
G
R
E
E
L
A
KNG
A
A
F
I
-
S
V
VSSN
P
D
L
L
KGI
D
S
K
R
I
A
A
F
Q
K
A
A
G
K
A
L
H
T
Y
R
Q
Y
I
Q
SDK
V
S
W
T
V
V
GAASAGWAHKVFP-GK
S
E
-
E
E
A
I
H
L
L
W
E
E
I
F
K
A
TRVNEDNP
V
Q
A
W
INHD
Q
N
L
H
E
K
V
-
D
H
LNER
H
Y
A
A
L
H
Y
QAEG
T
D
L
T
I
KLPRKHVWAG-AGS-V-NE--S
G
-
H
E
F
M
ANM
P
T
E
E
V
F
TLPQKDGVDGVVSSTKPLSYGG
N
I
I
E
N
F
T
L
T
FEN
G
R
I
V
D
I
KAEK
G
E
D
I
L
K
E
L
V
ETDEGS
H
Y
L
G
E
V
A
LVP--YDSPISQS
N
I
L
F
Y
----
N
T--LFDENASN
H
L
A
IG
S
A
Y
A
F
NIEGGKQM
S
R
E
E
L
V
K
EGL
N
E
SI
T
H
V
D
F
M
IGS-KDMNID
G
I
TADGKRE
P
I
FRNGNWAF---------
2
PsiBlast_PDB
80.97
51%
-73
- C2 -
4ICR
4
?
A:
[6-411]
---
F
K
E
N
L
E
K
Y
A
K
L
L
V
A
N
G
I
N
V
Q
P
G
H
T
L
A
L
S
I
D
V
E
Q
R
E
L
A
H
L
I
V
K
E
A
Y
A
L
G
A
H
E
V
I
V
Q
W
T
D
D
V
I
N
R
E
K
F
L
H
A
P
M
E
R
L
--
D
--
N
V
P
E
Y
K
I
A
E
M
N
Y
L
L
E
N
K
A
S
R
L
-
G
V
R
S
S
D
P
G
A
L
N
G
V
D
A
D
K
L
S
A
S
A
K
A
M
G
L
A
M
K
P
M
R
I
A
T
Q
S
N
K
V
S
W
T
V
A
A
A
A
G
L
E
W
A
K
K
V
F
P
N
A
A
S
D
-
E
E
A
V
D
F
L
W
D
Q
I
F
K
T
C
R
V
Y
E
A
D
P
V
K
A
W
E
E
H
A
A
I
L
K
S
K
A
-
D
M
L
N
K
E
Q
F
S
A
L
H
Y
T
A
P
G
T
D
L
T
L
G
L
P
K
N
H
V
W
E
S
-
A
G
A
-
V
-
N
A
--
Q
G
-
E
E
F
L
P
N
M
P
T
E
E
V
F
T
A
P
D
F
R
R
A
D
G
Y
V
T
S
T
K
P
L
S
Y
N
G
N
I
I
E
G
I
K
V
T
F
K
D
G
Q
I
V
D
I
T
A
E
K
G
D
Q
V
M
K
D
L
V
F
E
N
A
G
A
R
A
L
G
E
C
A
L
V
P
--
D
P
S
P
I
S
Q
S
G
I
T
F
F
----
N
T
--
L
F
D
D
N
A
S
N
H
L
A
I
G
A
A
Y
A
T
S
V
V
D
G
A
E
M
S
E
E
E
L
E
A
A
G
L
N
R
S
D
V
H
V
D
F
M
I
G
S
-
N
Q
M
D
I
D
G
I
R
E
D
G
T
R
V
P
L
F
R
N
G
N
W
-----------
9
PsiBlast_CBE
80.94
51%
-73
- C2 -
4ICR
4
?
B:
[6-411]
---
F
K
E
N
L
E
K
Y
A
K
L
L
V
A
N
G
I
N
V
Q
P
G
H
T
L
A
L
S
I
D
V
E
Q
R
E
L
A
H
L
I
V
K
E
A
Y
A
L
G
A
H
E
V
I
V
Q
W
T
D
D
V
I
N
R
E
K
F
L
H
A
P
M
E
R
L
--
D
--
N
V
P
E
Y
K
I
A
E
M
N
Y
L
L
E
N
K
A
S
R
L
-
G
V
R
S
S
D
P
G
A
L
N
G
V
D
A
D
K
L
S
A
S
A
K
A
M
G
L
A
M
K
P
M
R
I
A
T
Q
S
N
K
V
S
W
T
V
A
A
A
A
G
L
E
W
A
K
K
V
F
P
N
A
A
S
D
-
E
E
A
V
D
F
L
W
D
Q
I
F
K
T
C
R
V
Y
E
A
D
P
V
K
A
W
E
E
H
A
A
I
L
K
S
K
A
-
D
M
L
N
K
E
Q
F
S
A
L
H
Y
T
A
P
G
T
D
L
T
L
G
L
P
K
N
H
V
W
E
S
-
A
G
A
-
V
-
N
A
--
Q
G
-
E
E
F
L
P
N
M
P
T
E
E
V
F
T
A
P
D
F
R
R
A
D
G
Y
V
T
S
T
K
P
L
S
Y
N
G
N
I
I
E
G
I
K
V
T
F
K
D
G
Q
I
V
D
I
T
A
E
K
G
D
Q
V
M
K
D
L
V
F
E
N
A
G
A
R
A
L
G
E
C
A
L
V
P
--
D
P
S
P
I
S
Q
S
G
I
T
F
F
----
N
T
--
L
F
D
D
N
A
S
N
H
L
A
I
G
A
A
Y
A
T
S
V
V
D
G
A
E
M
S
E
E
E
L
E
A
A
G
L
N
R
S
D
V
H
V
D
F
M
I
G
S
-
N
Q
M
D
I
D
G
I
R
E
D
G
T
R
V
P
L
F
R
N
G
N
W
-----------
7
PsiBlast_CBE
80.48
52%
-65
- C2 -
4ICQ
2
?
B:
[3-412]
L
P
N
F
K
E
N
L
E
K
Y
A
K
L
L
V
A
N
G
I
N
V
Q
P
G
H
T
L
A
L
S
I
D
V
E
Q
R
E
L
A
H
L
I
V
K
E
A
Y
A
L
G
A
H
E
V
I
V
Q
W
T
D
D
V
I
N
R
E
K
F
L
H
A
P
M
E
R
L
--
D
--
N
V
P
E
Y
K
I
A
E
M
N
Y
L
L
E
N
K
A
S
R
L
-
G
V
R
S
S
D
P
G
A
L
N
G
V
D
A
D
K
L
S
A
S
A
K
A
M
G
L
A
M
K
P
M
R
I
A
T
Q
S
N
K
V
S
W
T
V
A
A
A
A
G
L
E
W
A
K
K
V
F
P
N
A
A
S
D
-
E
E
A
V
D
F
L
W
D
Q
I
F
K
T
C
R
V
Y
E
A
D
P
V
K
A
W
E
E
H
A
A
I
L
K
S
K
A
-
D
M
L
N
K
E
Q
F
S
A
L
H
Y
T
A
P
G
T
D
L
T
L
G
L
P
K
N
H
V
W
E
S
-
A
G
A
-
V
-
N
A
--
Q
G
-
E
E
F
L
P
N
M
P
T
E
E
V
F
T
A
P
D
F
R
R
A
D
G
Y
V
T
S
T
K
P
L
S
Y
N
G
N
I
I
E
G
I
K
V
T
F
K
D
G
Q
I
V
D
I
T
A
E
K
G
D
Q
V
M
K
D
L
V
F
E
N
A
G
A
R
A
L
G
E
C
A
L
V
P
--
D
P
S
P
I
S
Q
S
G
I
T
F
F
----
N
T
--
L
F
D
E
N
A
S
N
H
L
A
I
G
A
A
Y
A
T
S
V
V
D
G
A
E
M
S
E
E
E
L
E
A
A
G
L
N
R
S
D
V
H
V
D
F
M
I
G
S
-
N
Q
M
D
I
D
G
I
R
E
D
G
T
R
V
P
L
F
R
N
G
N
W
A
----------
8
PsiBlast_CBE
80.39
51%
-64
- C2 -
4ICS
4
?
B:
[3-412]
L
P
N
F
K
E
N
L
E
K
Y
A
K
L
L
V
A
N
G
I
N
V
Q
P
G
H
T
L
A
L
S
I
D
V
E
Q
R
E
L
A
H
L
I
V
K
E
A
Y
A
L
G
A
H
E
V
I
V
Q
W
T
D
D
V
I
N
R
E
K
F
L
H
A
P
M
E
R
L
--
D
--
N
V
P
E
Y
K
I
A
E
M
N
Y
L
L
E
N
K
A
S
R
L
-
G
V
R
S
S
D
P
G
A
L
N
G
V
D
A
D
K
L
S
A
S
A
K
A
M
G
L
A
M
K
P
M
R
I
A
T
Q
S
N
K
V
S
W
T
V
A
A
A
A
G
L
E
W
A
K
K
V
F
P
N
A
A
S
D
-
E
E
A
V
D
F
L
W
D
Q
I
F
K
T
C
R
V
Y
E
A
D
P
V
K
A
W
E
E
H
A
A
I
L
K
S
K
A
-
D
M
L
N
K
E
Q
F
S
A
L
H
Y
T
A
P
G
T
D
L
T
L
G
L
P
K
N
H
V
W
E
S
-
A
G
A
-
V
-
N
A
--
Q
G
-
E
E
F
L
P
N
M
P
T
E
E
V
F
T
A
P
D
F
R
R
A
D
G
Y
V
T
S
T
K
P
L
S
Y
N
G
N
I
I
E
G
I
K
V
T
F
K
D
G
Q
I
V
D
I
T
A
E
K
G
D
Q
V
M
K
D
L
V
F
E
N
A
G
A
R
A
L
G
E
C
A
L
V
P
--
D
P
S
P
I
S
Q
S
G
I
T
F
F
----
N
T
--
L
F
D
D
N
A
S
N
H
L
A
I
G
A
A
Y
A
T
S
V
V
D
G
A
E
M
S
E
E
E
L
E
A
A
G
L
N
R
S
D
V
H
V
D
F
M
I
G
S
-
N
Q
M
D
I
D
G
I
R
E
D
G
T
R
V
P
L
F
R
N
G
N
W
A
----------
3
PsiBlast_PDB
80.19
51%
-61
- C2 -
4ICS
4
?
A:
[3-412]
L
P
N
F
K
E
N
L
E
K
Y
A
K
L
L
V
A
N
G
I
N
V
Q
P
G
H
T
L
A
L
S
I
D
V
E
Q
R
E
L
A
H
L
I
V
K
E
A
Y
A
L
G
A
H
E
V
I
V
Q
W
T
D
D
V
I
N
R
E
K
F
L
H
A
P
M
E
R
L
--
D
--
N
V
P
E
Y
K
I
A
E
M
N
Y
L
L
E
N
K
A
S
R
L
-
G
V
R
S
S
D
P
G
A
L
N
G
V
D
A
D
K
L
S
A
S
A
K
A
M
G
L
A
M
K
P
M
R
I
A
T
Q
S
N
K
V
S
W
T
V
A
A
A
A
G
L
E
W
A
K
K
V
F
P
N
A
A
S
D
-
E
E
A
V
D
F
L
W
D
Q
I
F
K
T
C
R
V
Y
E
A
D
P
V
K
A
W
E
E
H
A
A
I
L
K
S
K
A
-
D
M
L
N
K
E
Q
F
S
A
L
H
Y
T
A
P
G
T
D
L
T
L
G
L
P
K
N
H
V
W
E
S
-
A
G
A
-
V
-
N
A
--
Q
G
-
E
E
F
L
P
N
M
P
T
E
E
V
F
T
A
P
D
F
R
R
A
D
G
Y
V
T
S
T
K
P
L
S
Y
N
G
N
I
I
E
G
I
K
V
T
F
K
D
G
Q
I
V
D
I
T
A
E
K
G
D
Q
V
M
K
D
L
V
F
E
N
A
G
A
R
A
L
G
E
C
A
L
V
P
--
D
P
S
P
I
S
Q
S
G
I
T
F
F
----
N
T
--
L
F
D
D
N
A
S
N
H
L
A
I
G
A
A
Y
A
T
S
V
V
D
G
A
E
M
S
E
E
E
L
E
A
A
G
L
N
R
S
D
V
H
V
D
F
M
I
G
S
-
N
Q
M
D
I
D
G
I
R
E
D
G
T
R
V
P
L
F
R
N
G
N
W
A
----------
1
PsiBlast_PDB
79.86
52%
-62
- C2 -
4ICQ
2
?
A:
[3-412]
L
P
N
F
K
E
N
L
E
K
Y
A
K
L
L
V
A
N
G
I
N
V
Q
P
G
H
T
L
A
L
S
I
D
V
E
Q
R
E
L
A
H
L
I
V
K
E
A
Y
A
L
G
A
H
E
V
I
V
Q
W
T
D
D
V
I
N
R
E
K
F
L
H
A
P
M
E
R
L
--
D
--
N
V
P
E
Y
K
I
A
E
M
N
Y
L
L
E
N
K
A
S
R
L
-
G
V
R
S
S
D
P
G
A
L
N
G
V
D
A
D
K
L
S
A
S
A
K
A
M
G
L
A
M
K
P
M
R
I
A
T
Q
S
N
K
V
S
W
T
V
A
A
A
A
G
L
E
W
A
K
K
V
F
P
N
A
A
S
D
-
E
E
A
V
D
F
L
W
D
Q
I
F
K
T
C
R
V
Y
E
A
D
P
V
K
A
W
E
E
H
A
A
I
L
K
S
K
A
-
D
M
L
N
K
E
Q
F
S
A
L
H
Y
T
A
P
G
T
D
L
T
L
G
L
P
K
N
H
V
W
E
S
-
A
G
A
-
V
-
N
A
--
Q
G
-
E
E
F
L
P
N
M
P
T
E
E
V
F
T
A
P
D
F
R
R
A
D
G
Y
V
T
S
T
K
P
L
S
Y
N
G
N
I
I
E
G
I
K
V
T
F
K
D
G
Q
I
V
D
I
T
A
E
K
G
D
Q
V
M
K
D
L
V
F
E
N
A
G
A
R
A
L
G
E
C
A
L
V
P
--
D
P
S
P
I
S
Q
S
G
I
T
F
F
----
N
T
--
L
F
D
E
N
A
S
N
H
L
A
I
G
A
A
Y
A
T
S
V
V
D
G
A
E
M
S
E
E
E
L
E
A
A
G
L
N
R
S
D
V
H
V
D
F
M
I
G
S
-
N
Q
M
D
I
D
G
I
R
E
D
G
T
R
V
P
L
F
R
N
G
N
W
A
----------
4
PsiBlast_PDB
78.33
47%
-70
- C2 -
1ZJC
3
?
A:
[6-415]
--
N
Y
K
E
K
L
Q
Q
Y
A
E
L
L
V
K
V
G
M
N
V
Q
P
K
Q
P
V
F
I
R
S
S
V
E
T
L
E
L
T
H
L
I
V
E
E
A
Y
H
C
G
A
S
D
V
R
V
V
Y
S
D
P
T
L
K
R
L
K
F
E
N
E
S
V
E
H
F
A
N
H
--
E
I
K
S
Y
D
V
E
A
R
M
D
Y
V
K
R
G
A
A
N
L
-
A
L
I
S
E
D
P
D
L
M
D
G
I
D
S
Q
K
L
Q
A
F
Q
Q
Q
N
A
R
A
F
K
G
Y
M
E
S
V
Q
K
N
Q
F
P
W
V
V
A
A
F
P
S
K
A
W
A
K
R
V
Y
P
-
E
L
S
V
-
E
E
A
Y
I
K
F
I
D
E
V
F
D
I
V
R
I
D
G
N
D
P
V
E
N
W
R
Q
H
I
A
N
L
S
V
Y
A
-
Q
K
L
Q
Q
K
N
Y
H
A
L
H
Y
V
S
E
G
T
D
L
T
V
G
L
A
K
N
H
I
W
E
D
-
A
T
S
Y
V
-
N
G
--
K
E
-
Q
A
F
I
A
N
I
P
T
E
E
V
F
T
A
P
D
R
N
R
V
D
G
Y
V
T
N
K
L
P
L
S
Y
N
G
T
I
I
D
Q
F
K
L
M
F
K
D
G
E
I
I
D
F
S
A
E
K
G
E
A
V
L
K
D
L
I
N
T
D
E
G
S
R
R
L
G
E
V
A
L
V
P
--
D
D
S
P
I
S
N
R
N
T
I
F
Y
----
N
T
--
L
F
D
E
N
A
A
C
H
L
A
I
G
S
A
Y
A
F
N
I
Q
G
G
T
E
M
T
V
E
E
K
I
A
S
G
L
N
D
S
N
V
H
V
D
F
M
I
G
S
-
S
D
L
T
I
Y
G
I
F
E
D
G
S
K
E
L
V
F
E
N
G
N
W
A
----------
25
HHSearch
78.24
50%
-57
- C2 -
4ICS
4
?
A:
[3-413]
L
P
N
F
K
E
N
L
E
K
Y
A
K
L
L
V
A
N
G
I
N
V
Q
P
G
H
T
L
A
L
S
I
D
V
E
Q
R
E
L
A
H
L
I
V
K
E
A
Y
A
L
G
A
H
E
V
I
V
Q
W
T
D
D
V
I
N
R
E
K
F
L
H
A
P
M
E
R
L
--
D
--
N
V
P
E
Y
K
I
A
E
M
N
Y
L
L
E
N
K
A
S
R
L
G
V
R
S
S
-
D
P
G
A
L
N
G
V
D
A
D
K
L
S
A
S
A
K
A
M
G
L
A
M
K
P
M
R
I
A
T
Q
S
N
K
V
S
W
T
V
A
A
A
A
G
L
E
W
A
K
K
V
F
P
-
N
A
A
S
D
E
E
A
V
D
F
L
W
D
Q
I
F
K
T
C
R
V
Y
E
A
D
P
V
K
A
W
E
E
H
A
A
I
L
K
S
K
A
-
D
M
L
N
K
E
Q
F
S
A
L
H
Y
T
A
P
G
T
D
L
T
L
G
L
P
K
N
H
V
W
E
S
-
A
G
A
-
V
-
N
A
--
Q
G
-
E
E
F
L
P
N
M
P
T
E
E
V
F
T
A
P
D
F
R
R
A
D
G
Y
V
T
S
T
K
P
L
S
Y
N
G
N
I
I
E
G
I
K
V
T
F
K
D
G
Q
I
V
D
I
T
A
E
K
G
D
Q
V
M
K
D
L
V
F
E
N
A
G
A
R
A
L
G
E
C
A
L
V
P
--
D
P
S
--
P
I
S
--
Q
S
G
ITFF
N
T
--
L
F
D
D
N
A
S
N
H
L
A
I
G
A
A
Y
A
T
S
V
V
D
G
A
E
M
S
E
E
E
L
E
A
A
G
L
N
R
S
D
V
H
V
D
F
M
I
G
S
-
N
Q
M
D
I
D
G
I
R
E
D
G
T
R
V
P
L
F
R
N
G
N
W
A
N
---------
14
Fugue
77.94
47%
-70
- C2 -
1ZJC
3
?
A:
[6-418]
--
N
Y
K
E
K
L
Q
Q
Y
A
E
L
L
V
K
V
G
M
N
V
Q
P
K
Q
P
V
F
I
R
S
S
V
E
T
L
E
L
T
H
L
I
V
E
E
A
Y
H
C
G
A
S
D
V
R
V
V
Y
S
D
P
T
L
K
R
L
K
F
E
N
E
S
V
E
H
F
--
A
NH
E
I
K
S
Y
D
V
E
A
R
M
D
Y
V
K
R
G
A
A
N
L
-
A
L
I
S
E
D
P
D
L
M
D
G
I
D
S
Q
K
L
Q
A
F
Q
Q
Q
N
A
R
A
F
K
G
Y
M
E
S
V
Q
K
N
Q
F
P
W
V
V
A
A
F
P
S
K
A
W
A
K
R
V
Y
P
-
E
L
S
V
-
E
E
A
Y
I
K
F
I
D
E
V
F
D
I
V
R
I
D
G
N
D
P
V
E
N
W
R
Q
H
I
A
N
L
S
V
Y
A
-
Q
K
L
Q
Q
K
N
Y
H
A
L
H
Y
V
S
E
G
T
D
L
T
V
G
L
A
K
N
H
I
W
E
D
-
A
T
S
-
Y
V
N
G
--
K
E
-
Q
A
F
I
A
N
I
P
T
E
E
V
F
T
A
P
D
R
N
R
V
D
G
Y
V
T
N
K
L
P
L
S
Y
N
G
T
I
I
D
Q
F
K
L
M
F
K
D
G
E
I
I
D
F
S
A
E
K
G
E
A
V
L
K
D
L
I
N
T
D
E
G
S
R
R
L
G
E
V
A
L
V
P
--
D
D
S
P
I
S
N
R
N
T
I
F
Y
----
N
T
--
L
F
D
E
N
A
A
C
H
L
A
I
G
S
A
Y
A
F
N
I
Q
G
G
T
E
M
T
V
E
E
K
I
A
S
G
L
N
D
S
N
V
H
V
D
F
M
I
G
S
-
S
D
L
T
I
Y
G
I
F
E
D
G
S
K
E
L
V
F
E
N
G
N
W
A
S
TF-------
24
HHSearch
77.46
47%
-69
- C2 -
1ZJC
3
?
A:
[6-416]
--
N
Y
K
E
K
L
Q
Q
Y
A
E
L
L
V
K
V
G
M
N
V
Q
P
K
Q
P
V
F
I
R
S
S
V
E
T
L
E
L
T
H
L
I
V
E
E
A
Y
H
C
G
A
S
D
V
R
V
V
Y
S
D
P
T
L
K
R
L
K
F
E
N
E
S
V
E
H
F
--
A
NH
E
I
K
S
Y
D
V
E
A
R
M
D
Y
V
K
R
G
A
A
N
L
A
L
I
S
E
-
D
P
D
L
M
D
G
I
D
S
Q
K
L
Q
A
F
Q
Q
Q
N
A
R
A
F
K
G
Y
M
E
S
V
Q
K
N
Q
F
P
W
V
V
A
A
F
P
S
K
A
W
A
K
R
V
Y
P
-
E
L
S
V
-
E
E
A
Y
I
K
F
I
D
E
V
F
D
I
V
R
I
D
G
N
D
P
V
E
N
W
R
Q
H
I
A
N
L
S
V
Y
A
-
Q
K
L
Q
Q
K
N
Y
H
A
L
H
Y
V
S
E
G
T
D
L
T
V
G
L
A
K
N
H
I
W
E
D
A
T
S
Y
-
V
-
N
G
K
E
Q
A
---
F
I
A
N
I
P
T
E
E
V
F
T
A
P
D
R
N
R
V
D
G
Y
V
T
N
K
L
P
L
S
Y
N
G
T
I
I
D
Q
F
K
L
M
F
K
D
G
E
I
I
D
F
S
A
E
K
G
E
A
V
L
K
D
L
I
N
T
D
E
G
S
R
R
L
G
E
V
A
L
V
P
--
D
D
S
P
I
S
N
R
N
T
I
F
Y
----
N
T
--
L
F
D
E
N
A
A
C
H
L
A
I
G
S
A
Y
A
F
N
I
Q
G
G
T
E
M
T
V
E
E
K
I
A
S
G
L
N
D
S
N
V
H
V
D
F
M
I
G
S
-
S
D
L
T
I
Y
G
I
F
E
D
G
S
K
E
L
V
F
E
N
G
N
W
A
S
---------
10
PsiBlast_CBE
75.60
44%
-83
- C2 -
2AYI
2
AMPT_THET8
E:
[3-406]
--
A
F
K
R
N
L
E
K
L
A
E
L
A
I
R
V
G
L
N
L
E
K
G
Q
E
V
I
A
T
A
P
I
E
A
V
D
F
V
R
L
L
A
E
K
A
Y
R
E
G
A
S
L
F
T
V
I
Y
G
D
Q
E
L
A
R
K
R
L
A
L
A
P
E
E
G
L
--
D
--
K
A
P
A
W
L
Y
E
G
M
A
R
A
F
R
E
G
A
A
R
L
-
A
V
S
G
S
D
P
K
A
L
E
G
L
P
P
E
K
V
G
R
A
Q
K
A
N
A
R
A
Y
K
P
A
L
E
A
I
T
E
F
V
T
N
W
T
I
V
P
F
A
H
P
G
W
A
R
A
V
F
P
-
G
L
P
E
-
E
E
A
V
R
R
L
W
E
A
I
F
Q
A
T
------
P
I
A
A
W
E
A
H
N
R
A
L
H
E
K
V
-
A
Y
L
N
A
R
R
F
H
A
L
H
F
K
G
P
G
T
D
L
V
V
G
L
A
E
G
H
L
W
Q
G
-
G
A
T
-
A
-
T
K
--
G
G
-
R
L
C
N
P
N
L
P
T
E
E
V
F
T
A
P
H
R
E
R
V
E
G
V
V
R
A
S
R
P
L
A
L
G
G
T
L
V
E
G
I
F
A
R
F
E
R
G
F
A
V
E
V
R
A
E
K
G
E
E
V
L
R
R
L
L
D
T
D
E
G
A
R
R
L
G
E
V
A
L
V
P
--
A
D
N
P
I
A
K
T
G
L
V
F
F
----
D
T
--
L
F
D
E
N
A
A
S
H
I
A
F
G
Q
A
Y
Q
E
N
L
E
G
-----
G
E
A
F
R
K
R
G
G
N
E
S
L
V
H
V
D
W
M
I
G
S
-
E
E
M
D
V
D
G
L
Y
E
D
G
T
R
T
P
L
M
R
R
G
R
W
-----------
12
PsiBlast_CBE
75.59
44%
-81
- C2 -
2AYI
2
AMPT_THET8
C:
[3-406]
--
A
F
K
R
N
L
E
K
L
A
E
L
A
I
R
V
G
L
N
L
E
K
G
Q
E
V
I
A
T
A
P
I
E
A
V
D
F
V
R
L
L
A
E
K
A
Y
R
E
G
A
S
L
F
T
V
I
Y
G
D
Q
E
L
A
R
K
R
L
A
L
A
P
E
E
G
L
--
D
--
K
A
P
A
W
L
Y
E
G
M
A
R
A
F
R
E
G
A
A
R
L
-
A
V
S
G
S
D
P
K
A
L
E
G
L
P
P
E
K
V
G
R
A
Q
K
A
N
A
R
A
Y
K
P
A
L
E
A
I
T
E
F
V
T
N
W
T
I
V
P
F
A
H
P
G
W
A
R
A
V
F
P
-
G
L
P
E
-
E
E
A
V
R
R
L
W
E
A
I
F
Q
A
T
------
P
I
A
A
W
E
A
H
N
R
A
L
H
E
K
V
-
A
Y
L
N
A
R
R
F
H
A
L
H
F
K
G
P
G
T
D
L
V
V
G
L
A
E
G
H
L
W
Q
G
-
G
A
T
-
A
-
T
K
--
G
G
-
R
L
C
N
P
N
L
P
T
E
E
V
F
T
A
P
H
R
E
R
V
E
G
V
V
R
A
S
R
P
L
A
L
G
G
T
L
V
E
G
I
F
A
R
F
E
R
G
F
A
V
E
V
R
A
E
K
G
E
E
V
L
R
R
L
L
D
T
D
E
G
A
R
R
L
G
E
V
A
L
V
P
--
A
D
N
P
I
A
K
T
G
L
V
F
F
----
D
T
--
L
F
D
E
N
A
A
S
H
I
A
F
G
Q
A
Y
Q
E
N
L
E
G
-----
G
E
A
F
R
K
R
G
G
N
E
S
L
V
H
V
D
W
M
I
G
S
-
E
E
M
D
V
D
G
L
Y
E
D
G
T
R
T
P
L
M
R
R
G
R
W
-----------
5
PsiBlast_PDB
74.99
44%
-80
- C2 -
2AYI
2
AMPT_THET8
A:
[3-406]
--
A
F
K
R
N
L
E
K
L
A
E
L
A
I
R
V
G
L
N
L
E
K
G
Q
E
V
I
A
T
A
P
I
E
A
V
D
F
V
R
L
L
A
E
K
A
Y
R
E
G
A
S
L
F
T
V
I
Y
G
D
Q
E
L
A
R
K
R
L
A
L
A
P
E
E
G
L
--
D
--
K
A
P
A
W
L
Y
E
G
M
A
R
A
F
R
E
G
A
A
R
L
-
A
V
S
G
S
D
P
K
A
L
E
G
L
P
P
E
K
V
G
R
A
Q
K
A
N
A
R
A
Y
K
P
A
L
E
A
I
T
E
F
V
T
N
W
T
I
V
P
F
A
H
P
G
W
A
R
A
V
F
P
-
G
L
P
E
-
E
E
A
V
R
R
L
W
E
A
I
F
Q
A
T
------
P
I
A
A
W
E
A
H
N
R
A
L
H
E
K
V
-
A
Y
L
N
A
R
R
F
H
A
L
H
F
K
G
P
G
T
D
L
V
V
G
L
A
E
G
H
L
W
Q
G
-
G
A
T
-
A
-
T
K
--
G
G
-
R
L
C
N
P
N
L
P
T
E
E
V
F
T
A
P
H
R
E
R
V
E
G
V
V
R
A
S
R
P
L
A
L
G
G
T
L
V
E
G
I
F
A
R
F
E
R
G
F
A
V
E
V
R
A
E
K
G
E
E
V
L
R
R
L
L
D
T
D
E
G
A
R
R
L
G
E
V
A
L
V
P
--
A
D
N
P
I
A
K
T
G
L
V
F
F
----
D
T
--
L
F
D
E
N
A
A
S
H
I
A
F
G
Q
A
Y
Q
E
N
L
E
G
-----
G
E
A
F
R
K
R
G
G
N
E
S
L
V
H
V
D
W
M
I
G
S
-
E
E
M
D
V
D
G
L
Y
E
D
G
T
R
T
P
L
M
R
R
G
R
W
-----------
13
PsiBlast_CBE
74.93
44%
-80
- C2 -
2AYI
2
AMPT_THET8
B:
[3-406]
--
A
F
K
R
N
L
E
K
L
A
E
L
A
I
R
V
G
L
N
L
E
K
G
Q
E
V
I
A
T
A
P
I
E
A
V
D
F
V
R
L
L
A
E
K
A
Y
R
E
G
A
S
L
F
T
V
I
Y
G
D
Q
E
L
A
R
K
R
L
A
L
A
P
E
E
G
L
--
D
--
K
A
P
A
W
L
Y
E
G
M
A
R
A
F
R
E
G
A
A
R
L
-
A
V
S
G
S
D
P
K
A
L
E
G
L
P
P
E
K
V
G
R
A
Q
K
A
N
A
R
A
Y
K
P
A
L
E
A
I
T
E
F
V
T
N
W
T
I
V
P
F
A
H
P
G
W
A
R
A
V
F
P
-
G
L
P
E
-
E
E
A
V
R
R
L
W
E
A
I
F
Q
A
T
------
P
I
A
A
W
E
A
H
N
R
A
L
H
E
K
V
-
A
Y
L
N
A
R
R
F
H
A
L
H
F
K
G
P
G
T
D
L
V
V
G
L
A
E
G
H
L
W
Q
G
-
G
A
T
-
A
-
T
K
--
G
G
-
R
L
C
N
P
N
L
P
T
E
E
V
F
T
A
P
H
R
E
R
V
E
G
V
V
R
A
S
R
P
L
A
L
G
G
T
L
V
E
G
I
F
A
R
F
E
R
G
F
A
V
E
V
R
A
E
K
G
E
E
V
L
R
R
L
L
D
T
D
E
G
A
R
R
L
G
E
V
A
L
V
P
--
A
D
N
P
I
A
K
T
G
L
V
F
F
----
D
T
--
L
F
D
E
N
A
A
S
H
I
A
F
G
Q
A
Y
Q
E
N
L
E
G
-----
G
E
A
F
R
K
R
G
G
N
E
S
L
V
H
V
D
W
M
I
G
S
-
E
E
M
D
V
D
G
L
Y
E
D
G
T
R
T
P
L
M
R
R
G
R
W
-----------
26
HHSearch
74.43
44%
-81
* C2 *
2AYI
2
AMPT_THET8
A:
[3-408]
--
A
F
K
R
N
L
E
K
L
A
E
L
A
I
R
V
G
L
N
L
E
K
G
Q
E
V
I
A
T
A
P
I
E
A
V
D
F
V
R
L
L
A
E
K
A
Y
R
E
G
A
S
L
F
T
V
I
Y
G
D
Q
E
L
A
R
K
R
L
A
L
A
P
E
E
G
L
--
D
--
K
A
P
A
W
L
Y
E
G
M
A
R
A
F
R
E
G
A
A
R
L
A
V
S
G
S
-
D
P
K
A
L
E
G
L
P
P
E
K
V
G
R
A
Q
K
A
N
A
R
A
Y
K
P
A
L
E
A
I
T
E
F
V
T
N
W
T
I
V
P
F
A
H
P
G
W
A
R
A
V
F
P
-
G
L
P
E
-
E
E
A
V
R
R
L
W
E
A
I
F
Q
A
T
------
P
I
A
A
W
E
A
H
N
R
A
L
H
E
K
V
-
A
Y
L
N
A
R
R
F
H
A
L
H
F
K
G
P
G
T
D
L
V
V
G
L
A
E
G
H
L
W
Q
G
--
G
A
-
T
-
A
T
--
K
G
G
R
L
C
N
P
N
L
P
T
E
E
V
F
T
A
P
H
R
E
R
V
E
G
V
V
R
A
S
R
P
L
A
L
G
G
T
L
V
E
G
I
F
A
R
F
E
R
G
F
A
V
E
V
R
A
E
K
G
E
E
V
L
R
R
L
L
D
T
D
E
G
A
R
R
L
G
E
V
A
L
V
P
AD
N
P
--
I
A
K
T
G
L
V
F
F
----
D
T
--
L
F
D
E
N
A
A
S
H
I
A
F
G
Q
A
Y
Q
E
N
L
E
G
-----
G
E
A
F
R
K
R
G
G
N
E
S
L
V
H
V
D
W
M
I
G
S
-
E
E
M
D
V
D
G
L
Y
E
D
G
T
R
T
P
L
M
R
R
G
R
W
V
V
---------
11
PsiBlast_CBE
74.28
44%
-77
- C2 -
2AYI
2
AMPT_THET8
D:
[3-406]
--
A
F
K
R
N
L
E
K
L
A
E
L
A
I
R
V
G
L
N
L
E
K
G
Q
E
V
I
A
T
A
P
I
E
A
V
D
F
V
R
L
L
A
E
K
A
Y
R
E
G
A
S
L
F
T
V
I
Y
G
D
Q
E
L
A
R
K
R
L
A
L
A
P
E
E
G
L
--
D
--
K
A
P
A
W
L
Y
E
G
M
A
R
A
F
R
E
G
A
A
R
L
-
A
V
S
G
S
D
P
K
A
L
E
G
L
P
P
E
K
V
G
R
A
Q
K
A
N
A
R
A
Y
K
P
A
L
E
A
I
T
E
F
V
T
N
W
T
I
V
P
F
A
H
P
G
W
A
R
A
V
F
P
-
G
L
P
E
-
E
E
A
V
R
R
L
W
E
A
I
F
Q
A
T
------
P
I
A
A
W
E
A
H
N
R
A
L
H
E
K
V
-
A
Y
L
N
A
R
R
F
H
A
L
H
F
K
G
P
G
T
D
L
V
V
G
L
A
E
G
H
L
W
Q
G
-
G
A
T
-
A
-
T
K
--
G
G
-
R
L
C
N
P
N
L
P
T
E
E
V
F
T
A
P
H
R
E
R
V
E
G
V
V
R
A
S
R
P
L
A
L
G
G
T
L
V
E
G
I
F
A
R
F
E
R
G
F
A
V
E
V
R
A
E
K
G
E
E
V
L
R
R
L
L
D
T
D
E
G
A
R
R
L
G
E
V
A
L
V
P
--
A
D
N
P
I
A
K
T
G
L
V
F
F
----
D
T
--
L
F
D
E
N
A
A
S
H
I
A
F
G
Q
A
Y
Q
E
N
L
E
G
-----
G
E
A
F
R
K
R
G
G
N
E
S
L
V
H
V
D
W
M
I
G
S
-
E
E
M
D
V
D
G
L
Y
E
D
G
T
R
T
P
L
M
R
R
G
R
W
-----------
28
HHSearch
36.41
19%
-240
- C2 -
2JVF
-
?
A:
[60-90]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
L
E
L
I
A
-
R
L
L
Q
K
L
G
Y
K
D
I
N
V
R
V
N
G
T
E
V
K
I
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
35.82
40%
-183
- C2 -
4FAS
-
?
D:
[35-49]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
V
E
N
G
K
I
V
R
V
K
C
G
D
------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
31.23
17%
-47
- C2 -
4K6N
1
PABC_YEAST
A:
[32-383]
-------------------------------
P
N
F
E
V
L
A
T
F
R
Y
D
P
G
F
A
R
Q
S
A
S
K
K
E
I
F
E
T
P
D
P
R
L
G
L
R
D
E
D
I
R
Q
Q
I
I
N
--
E
--
D
Y
S
S
Y
L
---
R
V
R
E
V
N
S
G
G
D
L
L
-
E
N
I
Q
-
H
P
D
A
W
K
H
-
D
C
K
T
I
V
C
Q
R
V
E
D
M
L
Q
V
I
Y
E
R
F
F
L
-
L
D
E
Q
Y
Q
R
I
R
I
A
L
S
Y
---
F
K
I
D
F
-
S
T
S
L
-
N
D
L
L
K
L
L
V
E
N
L
I
N
C
K
E
G
N
S
E
--------
Y
H
E
K
I
Q
K
M
I
N
E
R
Q
C
Y
K
M
R
V
L
V
S
K
T
G
D
I
R
I
E
A
I
P
M
P
M
E
P
I
L
K
L
-
T
T
D
-
Y
-
D
S
--
V
S
-
T
Y
F
I
K
T
M
L
--
N
G
F
L
I
D
S
T
I
N
W
D
V
V
V
S
S
E
P
L
N
A
------
S
A
F
T
S
F
K
T
T
S
R
---
D
H
Y
A
R
A
R
V
R
M
Q
T
A
I
N
N
L
R
G
S
---------
E
--
P
T
S
S
V
S
Q
C
E
I
L
F
S
----
N
K
SG
L
L
M
E
G
S
I
T
N
V
A
V
I
Q
K
D
P
---
N
G
S
K
K
Y
V
T
P
R
L
A
T
G
C
L
C
G
T
M
R
H
Y
L
L
R
L
G
L
I
E
E
G
D
I
D
I
G
S
L
T
V
G
N
E
V
L
L
F
N
G
V
M
G
C
I
K
G
T
VKTKY
32
HHSearch
30.82
18%
-70
- C2 -
3O6U
-
?
A:
[49-65]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
I
K
V
S
D
G
K
I
T
E
A
K
Y
N
-------------------------------------------------------------------------------------------------------------------------------------