@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15170: (2016-06-23 )
MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSLAKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNMSEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLSHVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDMKLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVDPSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWKRGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGILFPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTVKKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKYLENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVKPRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGTKVKEGSKIRVYLTEEDEKEAAD
Atome Classification :
(20 SA)
.........10........20........30........40.......----.50........60........70........80.......--------------------------.90------------.........100.......110.......120-........130----.......140..-.....150.......160.......170------.--------........180.......190.......200.....-.--.210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310..---.....--320.......330......----...340.......350.......360.......370.......380.......390.......400........410.......420.......430.......440.......450.......460.......470..---------.--------...-.-480-.----------..-...-..490.......500.--....--..--510.........520.......530......--.540.......550--.......560.......570.......580.......590.....-..600.--.-.....610.......620.......630.......---------640....-----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRVS
N
V
T
V
R
K
R
L
L
F
V
L
L
F
G
V
I
V
F
L
I
IDTRL
G
Y
V
Q
F
V
M
G
E
K
L
T
S
L
A
K
D
S----WSRNLPFEPERGEILDRN
G
V
K
L
ATNKSA
P
T
V
F
V
V
P
R
Q
VQN--------------------------
P
M
-------------
K
T
S
K
Q
L
A
A
V
LNM
S
E
E
K
V
Y
K
H
V
T
KKASIEKIT--PEGRKI
S
N
E
K
A
----
K
E
I
K
A
L
D
L
K
G
V
Y
-VAEDSIRHYP
F
G
S
F
L
S
H
V
L
GFAGIDN--------Q--------G
L
L
G
L
E
A
Y
YDDDLKGEKG
S
V
K
F
Y
TDAKGKKMPDEAD-D--YTPPKDG
L
D
M
K
L
T
V
D
S
K
V
Q
T
I
M
E
R
ELDNAE
A
K
YHPD
G
M
I
A
V
A
MNPKN
G
E
I
L
GMSSRPDFDPADYQSVDP
S
V
YNRNLPV
W
S
TYEPGS
T
F
K
I
I
T
L
A
A
A
L
E
E
QKVNLK
R
---
D
QFYD--KGHAEVDG
A
R
L
--
R
C
WKRG----GH
G
L
Q
T
Y
L
E
V
V
QNSCNP
G
F
V
E
L
G
E
RL
G
K
E
K
L
F
K
Y
I
K
D
FGFGQKT
G
I
D
LQGEG
T
G
I
L
F
P
L
E
RVG
P
-
V
E
Q
A
T
T
A
FGQGVSV
T
P
I
Q
Q
V
A
A
V
S
AAVNG
G
T
L
Y
T
P
Y
I
A
K
E
W
ID
P
V
T
K
K
T
V
KKQSPI
A
K
K
Q
V
I
S
E
E
T
S
K
Q
I
R
Y
A
L
---------
E
--------
S
V
V
-
A
-E-G-T----------GR-N
A
F
-
V
E
G
Y
RVGGKTGTAQKV--KDG
K
--
Y
L--E--NN
H
I
V
S
F
IGFAPADDP
S
L
V
V
Y
V
A
VDNPK--
G
T
I
Q
FGG
T
V
A
A
P
I
V
--
G
N
I
M
R
D
S
L
P
ELGVKP
R
K
N
Q
I
E
K
KYQWNDT
K
T
I
EVPNVVGM
S
V
S
D
L
-
E
S
L
L
V
N
--
L
-NVDASGKGS
K
I
V
KQSPAAGTKVKEG
S
K
I
R
V
Y
L
TEE---------
D
E
KEAAD-----------------------------------------
7
PsiBlast_PDB
84.76
31%
-71
- C1 -
5DF7
5
?
A:
[39-542]
------------------------------------------------------
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
84.19
30%
-72
- C1 -
3OC2
3
?
A:
[35-545]
----------------------------------------------
A
R
----
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
-
Q
-
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
---
I
V
D
V
Y
--
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
-----
S
R
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
-
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
------------
T
R
V
D
R
V
P
D
G
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
-
E
-
A
Q
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
-----------------
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
-------
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
N
L
----------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.17
31%
-75
- C1 -
4KQQ
6
?
B:
[42-542]
---------------------------------------------------------
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
-----------------
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
84.17
31%
-76
- C1 -
5DF8
9
?
B:
[42-542]
---------------------------------------------------------
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
---------------------
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.07
31%
-71
- C1 -
4KQR
10
?
B:
[39-542]
------------------------------------------------------
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.89
31%
-69
- C1 -
5DF8
8
?
A:
[39-542]
------------------------------------------------------
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.66
31%
-70
- C1 -
4KQR
11
?
A:
[39-542]
------------------------------------------------------
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.65
31%
-73
- C1 -
3OCN
1
?
A:
[39-542]
------------------------------------------------------
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
------------
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.55
31%
-74
- C1 -
4KQO
5
?
B:
[43-542]
----------------------------------------------------------
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
------------------
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.34
31%
-73
- C1 -
5DF9
4
?
A:
[39-542]
------------------------------------------------------
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
83.24
31%
-77
- C1 -
5DF7
7
?
B:
[42-542]
---------------------------------------------------------
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
---------------------
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.22
31%
-70
- C1 -
4KQO
3
?
A:
[39-542]
------------------------------------------------------
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.77
31%
-70
- C1 -
4KQQ
5
?
A:
[39-542]
------------------------------------------------------
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
N
P
K
E
L
M
T
--------------------------
A
K
-------------
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--
L
V
-
R
G
L
T
P
E
Q
G
----
E
G
V
I
A
L
K
V
P
G
V
Y
-
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
--------
R
--------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
--
T
K
N
A
K
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
-
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
--
W
K
P
---
S
D
I
V
D
VY
P
G
T
L
Q
I
G
R
Y
T
I
--
R
D
V
S
R
N
----
S
R
Q
L
D
-
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
-
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
--
V
D
R
V
P
D
G
V
----------
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
---------
Q
--------
Q
V
V
E
A
-
Q
-
G
-
G
----------
V
F
-
R
A
Q
-
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
K
V
--
S
V
G
T
KG
Y
R
--
E
--
N
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
--
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
--
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
-------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.12
26%
-
- C1 -
1PMD
-
PBPX_STRPN
A:
[76-695]
--------------------------------------------------------------
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
V
I
D
E
N
Y
K
--------------------------
S
A
TGKILYVEKTQFN
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
S
Q
-
P
N
L
K
Q
V
S
FG
A
K
G
N
G
I
T
Y
A
N
M
M
S
I
K
K
E
L
E
A
A
E
V
K
G
I
D
-
F
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
--------
N
EDGS
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
E
K
D
R
L
G
N
I
V
P
G
T
E
Q
-
V
--
S
Q
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
--
T
F
P
G
---
G
E
V
F
N
--
S
S
E
L
K
I
A
D
A
T
I
--
R
D
W
D
V
N
EGLT
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
-
P
A
D
N
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
-
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
GTDPVY
G
--------
T
M
Y
-
N
-
H
-
S
-
T
----------
G
K
P
T
V
T
-
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
--
Y
L
--
V
GL
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
HY
S
G
I
Q
L
-
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
Q
T
T
A
K
A
L
E
Q
V
S
Q
Q
S
P
Y
------
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
--
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
---------
E
E
----------------------------------------------
12
PsiBlast_PDB
70.57
26%
-30
- C1 -
1RP5
1
PBPX_STRPN
A:
[16-647]
------------------------------------------------K
V
H
Q
T
T
R
T
V
P
--
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
V
I
D
E
N
Y
K
--------------------------
S
A
TGKILYVEKTQ
F
N
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
S
Q
-
P
N
L
K
Q
V
S
F
G
A
K
G
N
G
I
T
Y
A
N
M
M
S
I
K
K
E
L
E
T
A
E
V
K
G
I
D
-
F
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
--------
N
EDG
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
E
K
D
R
L
G
N
I
V
P
G
T
E
Q
-
V
--
S
Q
Q
T
V
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
--
T
F
P
G
---
G
E
V
F
N
--
S
S
E
L
K
I
A
D
A
T
I
--
R
D
W
D
V
N
E
GLT
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
-
P
A
D
N
I
---
V
N
I
A
M
S
A
F
G
Q
G
I
S
V
T
Q
T
Q
M
L
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
L
Y
D
P
N
D
Q
S
V
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
E
A
A
S
V
T
R
D
H
M
V
---------
M
VGTDPTYG
T
M
Y
-
N
-
H
-
S
-
T
----------
G
K
-
A
T
V
N
V
P
G
Q
N
V
A
L
K
S
G
T
A
E
I
A
D
E
K
N
G
G
--
Y
L
T
G
S
--
T
N
N
I
F
S
V
V
S
M
H
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
E
HY
S
G
I
Q
L
-
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
E
S
L
N
L
Q
T
T
A
K
A
L
E
Q
V
S
Q
Q
S
P
Y
------
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
--
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
---------
E
E
----------------------------------------------
29
HHSearch
69.37
26%
-51
- C1 -
4YE5
5
?
A:
[21-557]
-----------------------------------------------
S
----
R
T
T
T
V
T
L
K
A
R
R
G
K
I
M
D
T
N
G
A
I
L
A
Q
S
V
E
R
Y
T
I
I
G
N
P
E
Q
A
Q
A
F
I
P
T
T
C
T
KQTGSN
C
H
Q
I
NGKPVGVTG
A
A
-------------
A
V
A
R
L
L
A
P
V
L
G
M
D
A
T
E
L
G
A
K
L
S
I
S
G
Q
Y
V
V
L
-----
K
K
D
V
T
P
A
V
K
----
R
K
I
S
K
L
N
L
G
G
I
V
Y
A
E
L
S
N
E
R
L
Y
S
N
G
T
L
M
G
S
L
L
G
G
V
D
A
D
G
--------
K
--------
G
V
A
G
I
E
Q
M
E
N
K
T
L
T
G
R
D
G
Y
Q
V
Y
Q
Q
G
N
S
G
V
E
I
P
G
T
M
T
-
E
--
S
K
D
A
V
N
G
S
D
V
T
L
T
I
D
R
D
V
Q
W
Y
T
E
K
V
L
S
D
S
E
N
K
Y
H
S
A
W
G
I
A
M
V
Q
D
V
Q
S
G
D
I
L
A
L
A
D
S
D
T
T
E
A
G
S
D
Q
A
----
K
M
G
A
S
R
A
V
S
E
T
F
E
P
G
S
I
G
K
V
L
A
M
S
G
M
L
Q
L
G
L
H
K
-
I
D
---
D
K
F
T
V
--
P
N
T
V
T
V
E
G
Q
T
Y
--
K
D
A
V
D
H
----
G
N
E
H
W
T
L
A
G
I
L
E
Q
S
S
N
V
G
M
V
I
A
G
D
K
M
T
N
E
Q
R
Y
N
F
I
S
K
F
G
I
G
Q
A
T
G
L
N
L
P
G
E
S
E
G
V
L
H
P
S
D
S
W
D
R
-
R
T
R
N
T
V
L
F
G
Q
G
Y
T
V
N
V
M
Q
L
T
N
A
I
S
V
I
A
N
K
G
V
K
K
P
Q
R
I
I
K
S
I
T
D
T
-
A
G
H
V
E
E
Q
Q
S
K
G
E
A
T
R
V
I
D
E
S
V
A
S
Q
M
L
N
A
M
---------
E
--------
S
S
A
-
E
-
H
-
Y
------------
N
T
-
F
V
K
-
V
D
G
Y
R
M
A
A
K
S
G
T
A
E
V
A
--
G
A
N
G
--
Q
L
-----
T
S
I
I
S
D
Y
S
T
I
I
P
A
D
N
P
R
F
V
I
T
V
V
L
K
D
P
Q
--
G
--
S
F
G
G
L
T
A
G
P
V
T
--
A
E
I
G
E
F
L
M
Q
K
Y
E
V
P
A
S
S
P
----------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
68.61
31%
-56
- C1 -
3EQU
11
PBP2_NEIGO
A:
[24-533]
----------------------------------------------
N
R
----
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
---------------------------------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
D
I
D
G
--------
K
--------
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
S
L
D
S
P
R
--
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
D
-
S
E
Q
R
R
N
R
A
V
T
D
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
-
L
N
---
E
R
L
N
T
--
Q
P
-
Y
K
I
G
P
S
P
V
--
R
D
T
H
------
V
Y
P
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
-
I
E
Q
A
T
M
S
F
G
Y
G
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
P
L
S
F
E
K
Q
A
V
A
P
-
Q
G
-----------
K
R
I
F
K
E
S
T
A
R
E
V
R
N
L
M
---------
V
--------
S
V
T
-
E
P
G
-
G
-
T
----------
G
T
-
A
G
A
-
V
D
G
F
D
V
G
A
K
T
G
T
A
-------------------
K
H
V
A
T
F
I
G
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
--
A
H
G
Y
Y
G
G
V
V
A
G
P
P
F
--
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
K
P
L
---------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.13
30%
-56
- C1 -
3EQU
11
PBP2_NEIGO
A:
[24-531]
----------------------------------------------
N
R
----
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
---------------------------------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
D
I
D
G
--------
K
--------
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
-
I
V
D
S
L
D
-
S
PR
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
D
-
S
E
Q
R
R
N
R
A
V
T
D
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
RLN
T
Q
P
Y
K
--
I
G
P
S
P
V
R
D
T
H
V
YP
S
L
D
V
R
G
-------------
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
-
I
E
Q
A
T
M
S
F
G
Y
G
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
P
L
S
F
E
K
Q
A
V
A
P
Q
G
K
R
I
F
K
------------
E
S
T
A
R
E
V
R
N
L
M
---------
V
--------
S
V
T
-
E
-
P
-
G
G
T
----------
G
T
-
A
G
A
-
V
D
G
F
D
V
G
A
K
T
G
T
A
-------------------
K
H
V
A
T
F
I
G
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
--
A
H
G
Y
Y
G
G
V
V
A
G
P
P
F
--
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
K
-----------------------------------------------------------------------------------------------------------------------------------
52
Fugue
65.82
27%
-36
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
---------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
----------------------------------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
EDG
S
K
S
L
L
--------
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
--
G
---
G
E
V
F
N
--
S
S
E
L
K
I
A
D
A
T
I
--
R
D
W
D
V
N
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GLT
G
G
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M
M
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F
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Q
G
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A
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N
V
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M
T
L
L
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M
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A
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L
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F
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G
Q
L
P
A
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N
---
I
-
V
N
I
A
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S
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G
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G
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T
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G
N
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K
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A
A
S
L
T
R
T
N
M
---------
V
--------
L
V
G
-
T
-
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-
P
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V
YGTMYNHSTG
K
P
-
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V
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K
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--
Y
L
--
V
GL
T
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A
V
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M
S
P
A
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N
P
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T
V
Q
Q
P
E
-----
H
Y
S
G
I
Q
L
G
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F
A
--
N
P
I
L
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R
A
S
A
M
K
D
S
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N
-----------
L
Q
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T
K
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A
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Q
G
SGSTVQKQDVRANTAIKDIK
K
I
T
L
T
L
G
D
1
PsiBlast_PDB
65.72
31%
-48
- C1 -
3EQV
9
PBP2_NEIGO
A:
[14-531]
------------------------------------
T
Y
N
F
L
K
E
Q
G
D
N
R
----
I
V
R
T
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A
L
P
A
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G
A
V
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A
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S
A
P
T
E
--------------------------------------------------------------------------------------------------------------------
E
L
K
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--------
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--------
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YP
S
L
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-------------
I
M
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R
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---------
V
--------
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V
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-
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-
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G
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----------
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A
K
T
G
T
A
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K
----------------
N
K
H
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I
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A
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--
A
H
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Y
Y
G
G
V
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F
--
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
K
-----------------------------------------------------------------------------------------------------------------------------------