@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15430: (2016-06-24 )
MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERTKDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIETALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEYEAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDGKGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASACGFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDFIIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHSYPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFTHPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSVDYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLIKLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSMQTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEKFDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVSELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEIVEKYYQK
Atome Classification :
(20 SA)
.........10........20........30........40........---50........60........70........80........90........100--........---.110----.-------..----..-.----.120---.......130---------......--..140........150...--..--..160....-...170.......180.......190.......----------200...-----------.------------------------.....210......-----------.220--------------------........230..--.....240.......250.....----.----.--260.......270......-.--280....--...--..290.......300--..---......310.......320.......330...----------.----------...340.------.------.----....350....-----------------------.--.--.360.......370....-...380.....-...390.......400.......410...--.--...420.....--..430-...--..-..440.......450--.........460..---.---...-.470...-....480.----..--....490.......500...-....510.-----------.-.....----------520-.........530--------.....-------------..-----.---540--------.-----...--..---...550.....------..560---.........570.-.-....-.580......-------------------------.----------------------------------------------590-------.------------------......600.......610.......620--..-.-.-.-..----.630.......-640........650..--.....660...-....670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770---..----......780.......790.......800.......810.......820.......830.....--..--840----.......850------------------.........860.......870.......880.......890.......900.......910.......920----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDFKDTLLMPKTDFPMRGNLPNREP
D
I
Q
K
KW
E
E
E
D
I
Y
R
L
V
Q
E
RTKDRP
K
---
F
V
LHDGPPYANG
D
I
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
KSMSGYNAPYVPGWDTHGLP----IETALTKN---KKV
N
----
R
-------
K
E----M
S
-
V
----
A
E
F
R
---
K
L
C
E
E
Y
A
W
K
----------
Q
IE
G
Q
R
--
E
Q
F
-
K
RLGVRGDWEN
P
Y
V
T
--LK--PEY
E
A
Q
Q
I
R
-
V
F
G
E
M
AKRG
Y
I
YKGLKPVNWSPSSESALA
E
A
E
I
----------
E
--
Y
QD-----------K------------------------R
S
A
S
I
Y
V
A
F
GVKDG-----------KGV---------------------LENG
E
R
I
I
I
W
TTT--
P
W
T
I
PANL
G
I
S
VHPDL
E
Y
S
V
I
A
V----G----E--D
R
F
V
V
A
S
A
L
V
E
N
V
A
S
ACGF-D--
Q
--
Y
E
V
T
--RTV--KG
K
D
L
E
N
I
I
A
EHPL---YG---RD
S
L
V
M
LGEHVTTDAGTG
C
V
HTAPGHGED
D
F
I
----------
I
----------
G
QKYG
L
D
------
V
------L----CPVDEKGVMTS-----------------------E--A--PGFE
G
M
F
YDD
A
N
K
A
I
T
Q
Q
-
L
DEKG-
A
L
V
K
L
-
E
F
I
THSYPHDWRTKK
P
T
I
F
R
A
T
A
Q
W
F
A
S
I
--
K
--
D
F
R
S
D
L
L
D
A
I
K
--ETKWV-PEW--
G
E
-
Q
R
L
H
N
M
V
R
DRG
D
W
----
C
I
SRQRAWGVP
I
P
V
---
F
---YAE-NGEPVI
T
-
D
E
T
I
E
H
V
S
----
E
L
--
F
R
QHGSN
I
W
F
E
K
E
A
K
D
LLPE-GFTHPGSP-----------N-GTFTK----------E---QD
I
M
D
VWFDSG---------S
S
H
Q
A
-------------
V
L
-----
E
---E----------R-----DDL--VR---PA
D
L
Y
LEGSD
Q
------
Y
R
G
-----
W
FNSSL
S
T
A
V
A
VT-G-KAP
Y
-
K
G
V
L
SHGFAL-------------------------D----------------------------------------------GEG-------
R
------------------
K
M
S
K
S
IG
N
V
V
V
P
A
K
V
M
K
Q
L
G
A
D
I
L
R
L
W
V
---
S
S-V-D-Y-QA----DV
R
V
S
D
A
I
L
K
Q
-
V
A
-
E
V
Y
R
K
I
R
N
T
F
R
F
L
--HGNLFDFDPKT-NA
V
A
V
E
D
L
R
E
V
D
Q
Y
M
L
I
K
L
N
K
L
I
D
K
V
K
K
A
Y
D
E
Y
E
F
A
V
V
Y
H
SIH
N
F
C
T
I
E
L
S
S
F
Y
L
D
F
AK
D
I
V
Y
I
EHADHP
D
R
R
S
M
Q
T
V
F
Y
E
T
L
L
A
L
V
K
LSAPILPH
T
A
D
E
L
W
S
H
L
T
----
F
V
----EEQS
V
Q
LTDMP
E
T
I
TVPNSE
A
T
E
E
K
F
D
R
F
M
A
L
R
D
D
V
L
K
A
L
E
T
ARNEKIIGKSLEA
N
L
K
LYPNKE--
N
K
--
E
L
L
----
A
S
I
K
E
N
L
S
--------------------
Q
L
F
I
V
S
E
L
T
ISEENEAPN
D
A
Q
SFAT
G
K
I
A
V
EKAE
G
E
M
C
E
R
S
R
V
I
S
KDVGANPKY
P
T
LSLR
N
A
E
I
V
E
K
Y
YQK-----
52
HHSearch
83.38
62%
-69
- C1 -
1FFY
5
SYI1_STAAU
A:
[1-916]
M
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
---
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
T
K
K
---
G
V
-
D
----
R
-------
K
K
----
M
S
-
T
----
A
E
F
R
---
E
K
C
K
E
F
A
L
E
----------
Q
I
E
L
Q
K
--
K
D
F
-
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
--
L
K
--
P
E
Y
E
A
A
Q
I
R
-
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
----------
E
--
Y
H
D
-----------
K
------------------------
R
S
A
S
I
Y
V
A
F
N
V
K
D
D
-----------
K
G
V
---------------------
V
D
A
D
A
K
F
I
I
W
T
T
T
--
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
----
G
--
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
-
D
--
K
AS
I
K
L
E
--
K
E
Y
--
T
G
K
E
L
E
W
V
V
A
Q
H
P
F
---
L
D
---
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
----------
G
Q
Q
Y
E
L
P
------
V
------
I
----
S
P
I
D
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
-
L
T
E
K
G
-
A
L
L
K
L
-
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
--
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
-
V
N
W
--
G
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
----
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
---
Y
A
E
-
N
G
E
I
I
M
T
-
K
E
T
V
N
H
V
A
----
D
L
--
F
A
E
H
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
H
P
G
S
P
-----------
N
-
G
T
F
T
K
----------
E
---
T
D
I
M
D
V
W
F
D
S
G
---------
S
S
H
R
G
-------------
V
L
-----
E
---
T
----------
R
-----
P
E
L
--
S
F
---
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
-----
W
F
N
S
S
I
T
T
S
V
A
T
R
-
G
-
V
S
P
Y
-
K
F
L
L
S
H
G
F
V
M
-------------------------
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
---
S
S
-
T
-
D
-
Y
-
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
S
-
D
D
Y
R
K
I
R
N
T
L
R
F
M
--
L
G
N
I
N
D
F
N
P
D
T
-
D
S
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
----
H
V
----
K
E
E
S
V
H
L
A
D
M
P
K
V
V
E
--
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
--
F
N
A
S
E
F
L
----
T
-
S
F
D
A
L
H
--------------------
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
D
Q
--
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
--------
3
PsiBlast_PDB
83.31
61%
-70
- C1 -
1FFY
5
SYI1_STAAU
A:
[1-914]
M
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
---
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
T
K
----
K
G
V
D
----
R
-------
K
K
----
M
S
-
T
----
A
E
F
R
---
E
K
C
K
E
F
A
L
E
----------
Q
I
E
L
Q
K
--
K
D
F
-
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
--
L
K
--
P
E
Y
E
A
A
Q
I
R
-
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
----------
E
--
Y
H
D
-----------
K
------------------------
R
S
A
S
I
Y
V
A
F
N
V
K
D
D
-----------
K
G
V
---------------------
V
D
A
D
A
K
F
I
I
W
T
T
T
--
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
----
G
--
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
-
D
--
K
--
A
S
I
K
L
E
K
E
Y
--
T
G
K
E
L
E
W
V
V
A
Q
H
P
F
---
L
D
---
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
----------
G
Q
Q
Y
E
L
P
------
V
------
I
----
S
P
I
D
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
-
L
T
E
K
G
-
A
L
L
K
L
-
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
--
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
-
V
N
W
--
G
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
----
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
---
Y
A
E
-
N
G
E
I
I
M
T
-
K
E
T
V
N
H
V
A
----
D
L
--
F
A
E
H
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
H
P
G
S
P
-----------
N
-
G
T
F
T
K
----------
E
---
T
D
I
M
D
V
W
F
D
S
G
---------
S
S
H
R
G
-------------
V
L
-----
E
---
T
----------
R
-----
P
E
L
--
S
F
---
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
-----
W
F
N
S
S
I
T
T
S
V
A
T
R
-
G
-
V
S
P
Y
-
K
F
L
L
S
H
G
F
V
M
-------------------------
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
---
S
S
-
T
-
D
-
Y
-
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
S
-
D
D
Y
R
K
I
R
N
T
L
R
F
M
--
L
G
N
I
N
D
F
N
P
D
T
-
D
S
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
----
H
V
----
K
E
E
S
V
H
L
A
D
M
P
K
V
V
E
V
--
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
FN
A
S
--
E
F
L
----
T
S
F
-
D
A
L
H
--------------------
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
--
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
----------
1
PsiBlast_PDB
83.31
61%
-70
- C1 -
1QU2
5
SYI1_STAAU
A:
[1-914]
M
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
---
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
T
K
----
K
G
V
D
----
R
-------
K
K
----
M
S
-
T
----
A
E
F
R
---
E
K
C
K
E
F
A
L
E
----------
Q
I
E
L
Q
K
--
K
D
F
-
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
--
L
K
--
P
E
Y
E
A
A
Q
I
R
-
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
----------
E
--
Y
H
D
-----------
K
------------------------
R
S
A
S
I
Y
V
A
F
N
V
K
D
D
-----------
K
G
V
---------------------
V
D
A
D
A
K
F
I
I
W
T
T
T
--
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
----
G
--
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
-
D
--
K
--
A
S
I
K
L
E
K
E
Y
--
T
G
K
E
L
E
W
V
V
A
Q
H
P
F
---
L
D
---
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
----------
G
Q
Q
Y
E
L
P
------
V
------
I
----
S
P
I
D
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
-
L
T
E
K
G
-
A
L
L
K
L
-
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
--
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
-
V
N
W
--
G
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
----
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
---
Y
A
E
-
N
G
E
I
I
M
T
-
K
E
T
V
N
H
V
A
----
D
L
--
F
A
E
H
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
H
P
G
S
P
-----------
N
-
G
T
F
T
K
----------
E
---
T
D
I
M
D
V
W
F
D
S
G
---------
S
S
H
R
G
-------------
V
L
-----
E
---
T
----------
R
-----
P
E
L
--
S
F
---
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
-----
W
F
N
S
S
I
T
T
S
V
A
T
R
-
G
-
V
S
P
Y
-
K
F
L
L
S
H
G
F
V
M
-------------------------
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
---
S
S
-
T
-
D
-
Y
-
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
S
-
D
D
Y
R
K
I
R
N
T
L
R
F
M
--
L
G
N
I
N
D
F
N
P
D
T
-
D
S
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
----
H
V
----
K
E
E
S
V
H
L
A
D
M
P
K
V
V
E
V
--
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
FN
A
S
--
E
F
L
----
T
S
F
-
D
A
L
H
--------------------
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
--
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
----------
42
Fugue
82.98
61%
-68
- C1 -
1QU2
5
SYI1_STAAU
A:
[1-917]
M
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
---
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
T
K
K
---
G
V
-
D
----
R
-------
K
K
----
M
S
-
T
----
A
E
F
R
---
E
K
C
K
E
F
A
L
E
----------
Q
I
E
L
Q
K
--
K
D
F
-
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
--
L
K
--
P
E
Y
E
A
A
Q
I
R
-
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
----------
E
--
Y
H
D
-----------
K
------------------------
R
S
A
S
I
Y
V
A
F
N
V
K
D
D
-----------
K
G
V
---------------------
V
D
A
D
A
K
F
I
I
W
T
T
T
--
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
----
G
--
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
-
D
--
K
AS
I
K
L
E
--
K
E
Y
--
T
G
K
E
L
E
W
V
V
A
Q
H
P
F
---
L
D
---
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
----------
G
Q
Q
Y
E
L
P
------
V
------
I
----
S
P
I
D
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
-
L
T
E
K
G
-
A
L
L
K
L
-
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
--
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
-
V
N
W
--
G
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
----
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
---
Y
A
E
-
N
G
E
I
I
M
T
-
K
E
T
V
N
H
V
A
----
D
L
--
F
A
E
H
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
H
P
G
S
P
-----------
N
-
G
T
F
T
K
----------
E
---
T
D
I
M
D
V
W
F
D
S
G
---------
S
S
H
R
G
-------------
V
L
-----
E
---
T
----------
R
-----
P
E
L
--
S
F
---
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
-----
W
F
N
S
S
I
T
T
S
V
A
T
R
-
G
-
V
S
P
Y
-
K
F
L
L
S
H
G
F
V
M
-------------------------
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
---
S
S
-
T
-
D
-
Y
-
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
S
-
D
D
Y
R
K
I
R
N
T
L
R
F
M
--
L
G
N
I
N
D
F
N
P
D
T
-
D
S
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
----
H
V
----
K
E
E
S
V
H
L
A
D
M
P
K
V
--
V
E
V
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
F-
N
A
--
S
E
F
----
L
T
S
F
D
A
L
H
--------------------
Q
L
F
I
V
S
Q
V
K
V
V
--
D
K
L
D
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
D
G
E
K
C
E
R
C
W
N
Y
S
E
D
L
G
A
V
D
E
L
T
H
L
C
P
R
C
Q
Q
V
V
K
S
L
V
-------
2
PsiBlast_PDB
80.97
61%
-77
- C1 -
1QU3
2
SYI1_STAAU
A:
[2-881]
-
D
Y
E
K
T
L
L
M
P
K
T
D
F
P
M
R
G
G
L
P
N
K
E
P
Q
I
Q
E
K
W
D
A
E
D
Q
Y
H
K
A
L
E
K
N
K
G
N
E
T
---
F
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
G
L
P
----
I
E
Q
A
L
T
K
----
K
G
V
D
----
R
-------
K
K
----
M
S
-
T
----
A
E
F
R
---
E
K
C
K
E
F
A
L
E
----------
Q
I
E
L
Q
K
--
K
D
F
-
R
R
L
G
V
R
G
D
F
N
D
P
Y
I
T
--
L
K
--
P
E
Y
E
A
A
Q
I
R
-
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
K
K
P
V
Y
W
S
P
S
S
E
S
S
L
A
E
A
E
I
----------
E
--
Y
H
D
-----------
K
------------------------
R
S
A
S
I
Y
V
A
F
N
V
K
D
D
-----------
K
G
V
---------------------
V
D
A
D
A
K
F
I
I
W
T
T
T
--
P
W
T
I
P
S
N
V
A
I
T
V
H
P
E
L
K
Y
G
Q
Y
N
V
----
N
----
G
--
E
K
Y
I
I
A
E
A
L
S
D
A
V
A
E
A
L
D
W
-
D
--
K
--
A
S
I
K
LE
K
E
Y
--
T
G
K
E
L
E
W
V
V
A
Q
H
P
F
---
L
D
---
R
E
S
L
V
I
N
G
D
H
V
T
T
D
A
G
T
G
C
V
H
T
A
P
G
H
G
E
D
D
Y
I
----------
V
----------
G
Q
Q
Y
E
L
P
------
V
------
I
----
S
P
I
D
D
K
G
V
F
T
E
-----------------------
E
--
G
--
G
Q
F
E
G
M
F
Y
D
K
A
N
K
A
V
T
D
L
-
L
T
E
K
G
-
A
L
L
K
L
-
D
F
I
T
H
S
Y
P
H
D
W
R
T
K
K
P
V
I
F
R
A
T
P
Q
W
F
A
S
I
--
S
--
K
V
R
Q
D
I
L
D
A
I
E
--
N
T
N
F
K
-
V
N
W
--
G
K
-
T
R
I
Y
N
M
V
R
D
R
G
E
W
----
V
I
S
R
Q
R
V
W
G
V
P
L
P
V
---
F
---
Y
A
E
-
N
G
E
I
I
M
T
-
K
E
T
V
N
H
V
A
----
D
L
--
F
A
E
H
G
S
N
I
W
F
E
R
E
A
K
D
L
L
P
E
-
G
F
T
H
P
G
S
P
-----------
N
-
G
T
F
T
K
----------
E
---
T
D
I
M
D
V
W
F
D
S
G
---------
S
S
H
R
G
-------------
V
L
-----
E
---
T
----------
R
-----
P
E
L
--
S
F
---
P
A
D
M
Y
L
E
G
S
D
Q
------
Y
R
G
-----
W
F
N
S
S
I
T
T
S
V
A
T
R
-
G
-
V
S
P
Y
-
K
F
L
L
S
H
G
F
V
M
-------------------------
D
----------------------------------------------
G
E
G
-------
K
------------------
K
M
S
K
S
L
G
N
V
I
V
P
D
Q
V
V
K
Q
K
G
A
D
I
A
R
L
W
V
---
S
S
-
T
-
D
-
Y
-
L
A
----
D
V
R
I
S
D
E
I
L
K
Q
-
T
S
-
D
D
Y
R
K
I
R
N
T
L
R
F
M
--
L
G
N
I
N
D
F
N
P
D
T
-
D
S
I
P
E
S
E
L
L
E
V
D
R
Y
L
L
N
R
L
R
E
F
T
A
S
T
I
N
N
Y
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
N
V
E
L
S
N
F
Y
L
D
Y
G
K
D
I
L
Y
I
E
Q
R
D
S
H
I
R
R
S
M
Q
T
V
L
Y
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
----
H
V
----
K
E
E
S
V
H
L
A
D
M
P
K
V
V
E
V
--
D
Q
A
L
L
D
K
W
R
T
F
M
N
L
R
D
D
V
N
R
A
L
E
T
A
R
N
E
K
V
I
G
K
S
L
E
A
K
V
T
I
A
S
N
D
K
FN
A
S
--
E
F
L
----
T
S
F
-
D
A
L
H
--------------------
Q
L
F
I
V
S
Q
V
K
V
V
D
K
L
D
--
D
Q
A
T
A
Y
E
H
G
D
I
V
I
E
H
A
-------------------------------------------
4
PsiBlast_PDB
70.15
31%
-85
- C1 -
1JZQ
3
SYI_THET8
A:
[9-816]
------------------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
N
R
K
G
G
P
R
---
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
----
V
E
L
E
V
E
K
K
---
L
G
L
K
----
S
-------
K
R
E
I
E
A
Y
G
-
I
----
E
R
F
N
---
Q
A
C
R
E
S
V
F
-----------
T
Y
E
K
E
W
--
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
--
L
E
--
P
T
Y
I
E
S
I
W
W
-
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
----------
A
L
G
Y
K
E
-----------
I
------------------------
Q
D
P
S
V
Y
V
R
F
P
L
K
E
P
-----------
K
K
L
---------------------
G
L
E
K
A
S
L
L
I
W
T
T
T
--
P
W
T
L
P
G
N
V
A
A
A
V
H
P
E
Y
T
Y
A
A
F
Q
V
----
G
----
D
--
E
A
L
I
L
E
E
G
L
G
R
K
L
L
G
-----
E
--
G
--
T
Q
V
L
--
K
T
F
--
P
G
K
A
L
E
G
L
P
Y
T
P
P
Y
PQA
L
E
---
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
----------
A
R
V
Y
G
L
P
------
L
------
L
----
K
T
V
D
E
E
G
K
L
L
V
-----------------------
E
--
P
----
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
-
L
R
G
R
G
-
L
L
F
K
E
-
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
--
T
--
L
F
K
D
E
L
I
R
N
N
Q
--
E
I
H
W
V
P
P
H
I
--
K
E
-
G
R
Y
G
E
W
L
K
N
L
V
D
W
----
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
---
V
C
Q
-
A
---
C
G
K
-
E
E
A
I
G
S
F
Q
----
E
L
------------
K
A
R
A
T
K
P
L
P
E
-
P
F
D
-
P
H
R
P
Y
V
D
Q
V
E
L
A
C
AC
G
-
G
T
M
R
R
----------
V
---
P
Y
V
I
D
V
W
Y
D
S
G
---------
A
M
P
F
A
-------------
S
L
-----
H
YPF
E
----------
H
-----
E
E
V
--
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
Q
------
T
R
G
-----
W
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
-
S
I
A
F
-
K
N
V
I
C
H
G
L
I
L
-------------------------
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
--
V
S
-
A
-
P
-
P
-
E
A
----
D
R
R
F
G
P
N
L
V
R
E
T
V
R
-
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
P
D
L
K
--
N
P
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
-
K
N
E
D
A
L
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
V
RSVR
L
E
----
A
K
E
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
E
A
-------
L
V
A
Q
M
R
A
V
L
K
V
V
D
L
A
R
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.76
31%
-85
- C1 -
1JZS
3
SYI_THET8
A:
[9-816]
------------------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
N
R
K
G
G
P
R
---
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
----
V
E
L
E
V
E
K
K
---
L
G
L
K
----
S
-------
K
R
E
I
E
A
Y
G
-
I
----
E
R
F
N
---
Q
A
C
R
E
S
V
F
-----------
T
Y
E
K
E
W
--
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
--
L
E
--
P
T
Y
I
E
S
I
W
W
-
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
----------
A
L
G
Y
K
E
-----------
I
------------------------
Q
D
P
S
V
Y
V
R
F
P
L
K
E
P
-----------
K
K
L
---------------------
G
L
E
K
A
S
L
L
I
W
T
T
T
--
P
W
T
L
P
G
N
V
A
A
A
V
H
P
E
Y
T
Y
A
A
F
Q
V
----
G
----
D
--
E
A
L
I
L
E
E
G
L
G
R
K
L
L
G
-----
E
--
G
--
T
Q
V
L
--
K
T
F
--
P
G
K
A
L
E
G
L
P
Y
T
P
P
Y
PQA
L
E
---
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
----------
A
R
V
Y
G
L
P
------
L
------
L
----
K
T
V
D
E
E
G
K
L
L
V
-----------------------
E
--
P
----
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
-
L
R
G
R
G
-
L
L
F
K
E
-
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
--
T
--
L
F
K
D
E
L
I
R
N
N
Q
--
E
I
H
W
V
P
P
H
I
--
K
E
-
G
R
Y
G
E
W
L
K
N
L
V
D
W
----
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
---
V
C
Q
-
A
---
C
G
K
-
E
E
A
I
G
S
F
Q
----
E
L
------------
K
A
R
A
T
K
P
L
P
E
-
P
F
D
-
P
H
R
P
Y
V
D
Q
V
E
L
A
C
AC
G
-
G
T
M
R
R
----------
V
---
P
Y
V
I
D
V
W
Y
D
S
G
---------
A
M
P
F
A
-------------
S
L
-----
H
YPF
E
----------
H
-----
E
E
V
--
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
Q
------
T
R
G
-----
W
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
-
S
I
A
F
-
K
N
V
I
C
H
G
L
I
L
-------------------------
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
--
V
S
-
A
-
P
-
P
-
E
A
----
D
R
R
F
G
P
N
L
V
R
E
T
V
R
-
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
P
D
L
K
--
N
P
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
-
K
N
E
D
A
L
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
V
RSVR
L
E
----
A
K
E
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
E
A
-------
L
V
A
Q
M
R
A
V
L
K
V
V
D
L
A
R
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.67
31%
-84
- C1 -
1ILE
2
SYI_THET8
A:
[9-816]
------------------
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
N
R
K
G
G
P
R
---
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
----
V
E
L
E
V
E
K
K
---
L
G
L
K
----
S
-------
K
R
E
I
E
A
Y
G
-
I
----
E
R
F
N
---
Q
A
C
R
E
S
V
F
-----------
T
Y
E
K
E
W
--
E
A
F
T
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
--
L
E
--
P
T
Y
I
E
S
I
W
W
-
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
----------
A
L
G
Y
K
E
-----------
I
------------------------
Q
D
P
S
V
Y
V
R
F
P
L
K
E
P
-----------
K
K
L
---------------------
G
L
E
K
A
S
L
L
I
W
T
T
T
--
P
W
T
L
P
G
N
V
A
A
A
V
H
P
E
Y
T
Y
A
A
F
Q
V
----
G
----
D
--
E
A
L
I
L
E
E
G
L
G
R
K
L
L
G
-----
E
--
G
--
T
Q
V
L
--
K
T
F
--
P
G
K
A
L
E
G
L
P
Y
T
P
P
Y
PQA
L
E
---
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
----------
A
R
V
Y
G
L
P
------
L
------
L
----
K
T
V
D
E
E
G
K
L
L
V
-----------------------
E
--
P
----
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
-
L
R
G
R
G
-
L
L
F
K
E
-
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
--
T
--
L
F
K
D
E
L
I
R
N
N
Q
--
E
I
H
W
V
P
P
H
I
--
K
E
-
G
R
Y
G
E
W
L
K
N
L
V
D
W
----
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
---
V
C
Q
-
A
---
C
G
K
-
E
E
A
I
G
S
F
Q
----
E
L
------------
K
A
R
A
T
K
P
L
P
E
-
P
F
D
-
P
H
R
P
Y
V
D
Q
V
E
L
A
CAC
G
-
G
T
M
R
R
----------
V
---
P
Y
V
I
D
V
W
Y
D
S
G
---------
A
M
P
F
A
-------------
S
L
-----
H
YPF
E
----------
H
-----
E
E
V
--
F
R
E
S
F
P
A
D
F
I
A
E
G
I
D
Q
------
T
R
G
-----
W
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
-
S
I
A
F
-
K
N
V
I
C
H
G
L
I
L
-------------------------
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
Y
--
V
S
-
A
-
P
-
P
-
E
A
----
D
R
R
F
G
P
N
L
V
R
E
T
V
R
-
D
Y
F
L
T
L
W
N
V
Y
S
F
F
V
T
Y
A
N
L
D
R
P
D
L
K
--
N
P
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
-
K
N
E
D
A
L
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
V
RSVR
L
E
----
A
K
E
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
E
A
-------
L
V
A
Q
M
R
A
V
L
K
V
V
D
L
A
R
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
66.10
30%
-82
- C1 -
1ILE
2
SYI_THET8
A:
[5-817]
--------------
V
G
E
P
N
F
P
K
L
E
E
E
V
L
A
F
W
K
R
E
K
I
F
Q
K
S
V
E
N
R
K
G
G
P
R
---
Y
T
V
Y
E
G
P
P
T
A
N
G
L
P
H
V
G
H
A
Q
A
R
S
Y
K
D
L
F
P
R
Y
K
T
M
R
G
Y
Y
A
P
R
R
A
G
W
D
T
H
G
L
P
----
V
E
L
E
V
E
K
K
---
L
G
L
K
S
K
R
E
I
-------
E
A
----
Y
G
-
I
----
E
R
F
N
---
Q
A
C
R
E
S
V
F
T
----------
Y
E
K
E
W
E
--
A
F
T
-
E
R
I
A
Y
W
V
D
L
E
D
A
Y
A
T
--
L
E
--
P
T
Y
I
E
S
I
W
W
-
S
L
K
N
L
F
D
R
G
L
L
Y
R
D
H
K
V
V
P
Y
C
P
R
C
G
T
P
L
S
S
H
E
V
A
L
--------
G
--
Y
K
E
-----------
I
------------------------
Q
D
P
S
V
Y
V
R
F
P
L
K
E
P
-----------
K
K
L
---------------------
G
L
E
K
A
S
L
L
I
W
T
T
T
--
P
W
T
L
P
G
N
V
A
A
A
V
H
P
E
Y
T
Y
A
A
F
Q
V
----
G
----
D
--
E
A
L
I
L
E
E
G
L
G
R
K
L
L
G
E
-------
G
--
T
Q
V
L
--
K
T
F
--
P
G
K
A
L
E
G
L
P
Y
T
P
P
Y
---
P
Q
ALE
K
G
Y
F
V
V
L
A
D
Y
V
S
Q
E
D
G
T
G
I
V
H
Q
A
P
A
F
G
A
E
D
L
E
----------
T
----------
A
R
V
Y
G
L
P
------
L
------
L
----
K
T
V
D
E
E
G
K
L
L
V
-----------------------------
E
P
F
K
G
L
Y
F
R
E
A
N
R
A
I
L
R
D
-
L
R
G
R
G
-
L
L
F
K
E
-
E
S
Y
L
H
S
Y
P
H
C
W
R
C
S
T
P
L
M
Y
Y
A
T
E
S
W
F
I
K
N
--
T
--
L
F
K
D
E
L
I
R
N
N
Q
--
E
I
H
W
V
-
P
P
H
--
I
K
E
G
R
Y
G
E
W
L
K
N
L
V
D
W
----
A
L
S
R
N
R
Y
W
G
T
P
L
P
I
---
W
---
V
C
Q
A
C
G
K
E
E
A
I
--
G
S
F
Q
E
L
K
----
A
R
--
A
T
K
-
P
L
P
E
P
F
D
-
P
H
R
P
Y
V
D
Q
V
E
L
A
C
-
A
C
G
-------------
G
T
M
R
R
----------
V
---
P
Y
V
I
D
V
W
Y
D
S
G
---------
A
M
P
F
A
-------------
S
L
-----
H
---
Y
PFEH
E
E
----
V
-----
F
R
E
--
S
F
---
P
A
D
F
I
A
E
G
I
D
Q
------
T
R
G
-----
W
F
N
S
L
H
Q
L
G
V
M
L
F
-
G
-
S
I
A
F
-
K
N
V
I
C
H
G
L
I
L
-------------------------
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
V
D
P
W
D
I
I
R
K
F
G
A
D
A
L
R
W
Y
I
---
Y
V
-
S
-
A
-
P
P
E
A
----
D
R
R
F
G
P
N
L
V
R
E
-
T
V
R
D
Y
F
L
T
L
W
N
V
Y
S
F
F
--
V
T
Y
A
N
L
D
R
P
D
L
K
N
P
P
P
P
E
K
R
P
E
M
D
R
W
L
L
A
R
M
Q
D
L
I
Q
R
V
T
E
A
L
E
A
Y
D
P
T
T
S
A
R
A
L
R
D
F
V
V
E
D
L
S
Q
W
Y
V
R
R
N
R
R
R
F
W
K
N
E
D
-
A
L
D
R
E
A
A
Y
A
T
L
Y
E
A
L
V
L
V
A
T
L
A
A
P
F
T
P
F
L
A
E
V
L
W
Q
N
L
V
----
R
S
VRLE
A
K
E
S
V
H
L
A
D
W
P
E
A
D
P
A
L
A
D
E
A
L
V
A
Q
M
R
A
V
L
K
V
V
D
L
A
R
A
A
R
A
--------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
62.14
26%
-76
- C1 -
1GAX
3
SYV_THETH
A:
[2-749]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
F
V
A
N
P
-
K
--
S
G
K
P
P
---
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
----
T
Q
V
V
V
E
R
L
---
L
L
K
E
GKT-
R
-------
H
D
----
L
G
-
R
----
E
K
F
L
---
E
R
V
W
Q
W
K
E
E
----------
S
G
G
T
I
L
--
K
Q
L
-
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
--
M
D
--
E
K
R
S
R
A
V
R
Y
-
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
----------
E
--
T
E
P
-----------
T
------------------------
P
G
K
L
Y
T
L
R
Y
E
V
E
G
---------------------------------------
G
G
F
I
E
I
A
T
V
R
--
P
E
T
V
F
A
D
Q
A
I
A
V
H
P
E
D
E
R
Y
-------------------------------------------------------
R
H
L
L
G
K
R
A
R
I
P
L
---
T
E
---
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
----------
G
E
R
H
G
L
K
------
P
------
V
----
S
V
I
N
L
E
G
R
M
E
G
-----------------------
E
--
R
VP
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
-
F
R
E
A
G
-
H
L
V
K
E
-
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
--
R
--
P
L
A
E
E
V
L
K
G
L
R
R
G
D
I
A
F
V
-
P
E
R
--
W
K
-
K
V
N
M
D
W
L
E
N
V
K
D
W
----
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
---
Y
C
E
D
C
Q
A
V
N
V
P
----------------------------
R
P
E
-
R
Y
L
E
D
-
P
T
S
C
E
A
C
G
-----------
S
-
P
R
L
K
R
----------
D
---
E
D
V
F
D
T
W
F
S
S
A
---------
L
W
P
L
S
-------------
T
L
-----
G
---
W
----------
P
EET
E
D
L
K
A
--
F
Y
---
P
G
D
V
L
V
T
G
Y
D
I
------
L
F
L
-----
W
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
-
E
R
P
F
-
K
T
V
L
L
H
G
L
V
L
-------------------------
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
---
I
Y
-
L
-
A
-
T
G
G
Q
----
D
I
R
L
D
L
R
W
L
E
M
-
A
R
-
N
F
A
N
K
L
Y
N
A
A
R
F
V
--
L
L
S
R
E
G
F
Q
A
K
------
E
D
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
N
------
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
----
G
------
K
E
E
L
A
L
E
A
W
P
E
P
G
G
--
R
D
E
E
A
E
R
A
F
E
A
L
K
Q
A
V
T
A
V
R
A
L
----
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
-------------------------------------------------------------------------------------------------------------------------
44
Fugue
61.46
24%
-70
- C1 -
1GAX
3
SYV_THETH
A:
[1-862]
M
D
L
P
K
A
Y
-----------
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
F
V
A
---
N
P
K
S
G
K
P
P
---
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
----
T
Q
V
V
V
E
R
L
LLK
E
G
K
T
----
R
-------
H
D
----
L
G
-
R
----
E
K
F
L
---
E
R
V
W
Q
W
K
E
E
----------
S
G
G
T
I
L
--
K
Q
L
-
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
--
M
D
--
E
K
R
S
R
A
V
R
Y
-
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
----------
E
--
T
E
P
-----------
T
------------------------
P
G
K
L
Y
T
L
R
Y
E
---------------------------------------
V
E
G
G
G
F
I
E
I
A
T
V
R
--
P
E
T
V
F
A
D
Q
A
I
A
V
H
P
E
-----------------
D
--
E
R
Y
------------------------------------
R
H
L
L
G
K
R
A
R
I
P
L
---
T
E
---
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
----------
G
E
R
H
G
L
K
------
P
------
V
----
S
V
I
N
L
E
G
R
M
E
G
-----------------------
E
--
R
VP
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
-
F
R
E
A
G
-
H
L
V
K
E
-
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
--
R
--
P
L
A
E
E
V
L
K
G
L
R
R
G
D
I
A
F
V
-
P
E
R
--
W
K
-
K
V
N
M
D
W
L
E
N
V
K
D
W
----
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
---
Y
C
E
-
D
C
Q
A
V
N
V
-
P
R
-------------------------
P
E
R
Y
L
E
D
P
T
-
S
C
E
A
C
G
S
P
-----------
R
---
L
K
R
----------
D
---
E
D
V
F
D
T
W
F
S
S
A
---------
L
W
P
L
S
-------------
T
L
GWPEE
T
---
E
----------
D
-----
L
K
A
--
F
Y
---
P
G
D
V
L
V
T
G
Y
D
I
------
L
F
L
-----
W
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
-
E
R
P
F
-
K
T
V
L
L
H
G
L
V
L
-------------------------
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
A
L
---
I
Y
L
A
-
T
-
G
-
G
Q
----
D
I
R
L
D
L
R
W
L
E
M
-
A
R
-
N
F
A
N
K
L
Y
N
A
A
R
F
V
--
L
L
S
R
E
G
F
Q
A
K
E
-
D
-----
T
P
T
L
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
------
A
G
N
A
H
T
L
R
T
L
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
----------
G
K
E
E
L
A
L
E
A
W
P
E
------
P
G
G
R
D
E
E
A
E
R
A
F
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
V
R
V
Y
L
E
G
E
T
A
--
P
V
--
E
E
N
----
L
E
V
F
R
F
L
S
R
A
D
L
L
PERPA
K
A
L
V
K
A
M
PR
V
T
A
R
M
P
L
E
G
L
L
D
V
E
E
W
R
R
R
Q
E
K
R
L
K
E
L
L
A
L
A
E
R
S
Q
R
K
L
A
S
P
G
F
R
E
K
A
P
K
E
V
V
E
A
E
E
A
R
L
K
E
N
L
E
Q
A
E
R
I
R
E
A
L
S
Q
IG
8
PsiBlast_PDB
61.29
25%
-70
- C1 -
1IVS
1
SYV_THETH
A:
[2-776]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
---
F
V
A
N
P
K
S
G
K
P
P
---
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
L
K
E
---
G
K
-
T
----
R
-------
H
D
----
L
G
-
R
----
E
K
F
-----
L
E
R
V
W
Q
W
K
----------
E
E
S
G
G
T
I
L
K
Q
L
-
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
--
M
D
---
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
----------
E
--
T
E
P
-----------
T
-------------------------
P
G
K
L
Y
T
L
R
Y
E
V
E
G
-----------
G
G
F
---------------------
I
E
------
I
A
T
V
R
--
P
E
T
V
F
A
D
Q
A
I
A
V
H
P
E
-----------------
D
--
E
R
Y
-----------------------------
R
H
L
--
L
G
K
R
-----
A
R
I
P
L
---
T
E
---
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
----------
G
E
R
H
G
L
K
------
P
------
V
----
S
V
I
N
L
E
G
R
M
E
G
-----------------------
E
RV
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
-
F
R
E
A
G
-
H
L
V
K
E
-
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
--
R
--
P
L
A
E
E
V
L
K
G
L
R
R
G
D
I
A
F
V
-
P
E
R
--
W
K
-
K
V
N
M
D
W
L
E
N
V
K
D
W
----
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
---
Y
C
E
-
D
C
Q
A
V
N
V
-
P
R
P
E
R
Y
L
E
----
D
---------------------
P
T
-
S
C
E
A
C
G
S
P
-----------
R
---
L
K
R
----------
D
---
E
D
V
F
D
T
W
F
S
S
A
---------
L
W
P
L
S
-------------
T
L
GWP--
E
---
E
----------
T
-----
E
D
L
K
A
F
Y
---
P
G
D
V
L
V
T
G
Y
D
I
------
L
F
L
-----
W
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
-
E
R
P
F
-
K
T
V
L
L
H
G
L
V
L
-------------------------
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
------
A
-
L
-
I
-
Y
-
L
A
TGG
Q
D
I
R
L
D
L
R
W
L
E
M
-
A
R
-
N
F
A
N
K
L
Y
N
A
A
R
F
V
--
L
L
S
R
E
G
F
Q
A
K
E
-
D
T
P
T
L
-----
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
N
A
-----
H
T
L
R
T
L
-
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
----
G
K
----
E
E
L
A
L
E
--------
A
W
P
E
P
G
G
R
D
E
E
A
E
R
----------
A
F
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
--
V
R
--
V
Y
L
E
G
ET
A
P
V
E
E
N
L
E
--------------------
V
F
R
F
L
S
R
A
D
L
L
P
E
R
P
A
------------------------------------------------------------
7
PsiBlast_PDB
61.01
25%
-70
- C1 -
1GAX
3
SYV_THETH
A:
[2-776]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
---
F
V
A
N
P
K
S
G
K
P
P
---
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
L
K
E
---
G
K
-
T
----
R
-------
H
D
----
L
G
-
R
----
E
K
F
-----
L
E
R
V
W
Q
W
K
----------
E
E
S
G
G
T
I
L
K
Q
L
-
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
--
M
D
---
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
----------
E
--
T
E
P
-----------
T
-------------------------
P
G
K
L
Y
T
L
R
Y
E
V
E
G
-----------
G
G
F
---------------------
I
E
------
I
A
T
V
R
--
P
E
T
V
F
A
D
Q
A
I
A
V
H
P
E
-----------------
D
--
E
R
Y
-----------------------------
R
H
L
--
L
G
K
R
-----
A
R
I
P
L
---
T
E
---
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
----------
G
E
R
H
G
L
K
------
P
------
V
----
S
V
I
N
L
E
G
R
M
E
G
-----------------------
E
RV
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
-
F
R
E
A
G
-
H
L
V
K
E
-
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
--
R
--
P
L
A
E
E
V
L
K
G
L
R
R
G
D
I
A
F
V
-
P
E
R
--
W
K
-
K
V
N
M
D
W
L
E
N
V
K
D
W
----
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
---
Y
C
E
-
D
C
Q
A
V
N
V
-
P
R
P
E
R
Y
L
E
----
D
---------------------
P
T
-
S
C
E
A
C
G
S
P
-----------
R
---
L
K
R
----------
D
---
E
D
V
F
D
T
W
F
S
S
A
---------
L
W
P
L
S
-------------
T
L
GWP--
E
---
E
----------
T
-----
E
D
L
K
A
F
Y
---
P
G
D
V
L
V
T
G
Y
D
I
------
L
F
L
-----
W
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
-
E
R
P
F
-
K
T
V
L
L
H
G
L
V
L
-------------------------
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
------
A
-
L
-
I
-
Y
-
L
A
TGG
Q
D
I
R
L
D
L
R
W
L
E
M
-
A
R
-
N
F
A
N
K
L
Y
N
A
A
R
F
V
--
L
L
S
R
E
G
F
Q
A
K
E
-
D
T
P
T
L
-----
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
N
A
-----
H
T
L
R
T
L
-
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
----
G
K
----
E
E
L
A
L
E
--------
A
W
P
E
P
G
G
R
D
E
E
A
E
R
----------
A
F
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
--
V
R
--
V
Y
L
E
G
ET
A
P
V
E
E
N
L
E
--------------------
V
F
R
F
L
S
R
A
D
L
L
P
E
R
P
A
------------------------------------------------------------
20
PsiBlast_PDB
59.99
22%
-84
- C1 -
1WKB
8
SYL_PYRHO
A:
[5-809]
------------------
N
F
K
A
I
E
E
K
W
Q
K
R
W
L
E
A
K
I
F
---
E
P
N
I
R
D
K
P
K
EK
K
F
Y
I
T
V
A
F
P
Y
L
S
G
H
L
H
V
G
H
A
R
T
Y
T
I
P
D
V
I
A
R
F
K
R
M
Q
G
Y
N
V
L
F
P
M
A
W
H
I
T
G
S
P
----
I
V
G
I
A
E
R
I
---
K
--
N
----
R
-------
D
P
----
K
T
-
I
----
W
I
Y
R
DVY
K
V
P
E
E
I
L
W
T
FED
P
I
N
I
V
K
Y
F
M
K
A
A
K
--
E
T
F
-
I
R
A
G
F
S
V
D
W
S
R
E
F
Y
T
T
S
L
F
--
P
P
F
S
K
F
I
E
W
-
Q
F
W
K
L
K
E
K
G
Y
I
V
K
G
A
H
R
V
R
W
D
P
V
V
G
T
P
L
G
D
H
D
L
----------
M
--
E
G
E
-----------
D
------------------------
V
P
I
L
D
Y
I
I
I
K
F
E
---------------
L
---------------------
R
E
N
G
E
V
I
Y
L
P
A
A
T
LR
P
E
T
V
Y
G
V
T
N
M
W
V
N
P
N
A
T
Y
V
K
A
K
V
R
R
KD
K
----
E
--
E
T
W
I
V
S
----
K
E
A
A
Y
K
L
S
F
-
Q
D
R
E
--
I
E
V
I
--
E
E
F
--
K
G
E
K
L
I
G
K
Y
V
R
N
P
V
---
S
G
---
D
E
V
I
I
L
P
A
E
F
V
D
P
D
N
A
T
G
V
V
M
S
V
P
A
H
A
P
F
D
H
V
A
L
E
D
L
K
R
E
TE
I
----------
L
E
K
Y
D
I
D
PRIVFP
A
------
V
----
E
E
V
N
K
L
G
I
K
S
Q
KDKEK
L
E
Q
A
T
K
T
I
Y
K
A
E
Y
H
K
G
I
F
K
--
V
--
P
P
Y
E
G
K
P
V
Q
E
V
K
E
A
I
A
K
E
-
M
L
E
K
G
I
A
E
I
M
Y
-
E
F
A
E
K
N
V
I
S
R
F
-
G
N
R
A
V
I
K
I
I
H
D
Q
W
F
I
D
Y
GN
P
--
E
W
K
E
K
A
R
K
A
L
E
--
R
M
K
I
L
-
P
E
T
--
R
R
-
A
Q
F
E
A
I
I
----
D
W
LDKK
A
C
A
R
K
I
G
L
G
T
P
L
P
----
W
---
D
P
E
-
W
V
I
E
S
L
S
-
D
S
T
I
Y
M
A
Y
----
Y
T
--
I
S
R
H
I
N
K
L
---
R
Q
E
G
K
L
D
P
E
-
K
L
T
-
P
E
F
F
-----------
D
-
Y
I
F
L
E
----------
E
FS
E
D
K
E
K
E
L
E
K
K
T
G
---------
I
P
A
E
I
-------------
I
H
-----
E
---
M
----------
K
-----
E
E
F
E
Y
W
Y
---
P
L
D
W
R
C
S
G
K
D
L
------
I
P
N
-----
H
L
T
F
F
I
F
N
H
V
A
I
F
-
R
-
E
E
H
W
P
K
G
I
A
V
N
G
F
G
--------------------------
T
----------------------------------------------
L
E
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
L
N
F
I
D
A
I
E
E
N
G
A
D
V
V
R
L
Y
I
---
M
S
-
L
A
E
-
H
-
D
S
----
D
F
---
D
W
R
R
K
E
-
V
G
-
K
L
R
K
Q
I
E
R
F
Y
E
L
I
---
S
Q
F
A
E
Y
E
V
K
G
-
N
V
----
E
L
K
D
I
D
R
W
M
L
H
R
L
N
K
A
I
K
E
T
T
N
A
L
E
E
F
R
T
R
T
A
V
Q
----------
W
A
F
Y
S
I
M
N
D
L
R
W
Y
L
R
R
T
E
G
R
D
D
E
A
K
R
Y
V
L
R
T
L
A
D
V
W
V
R
L
M
A
P
F
T
P
H
I
C
E
E
L
W
E
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
58.68
23%
-83
- C1 -
2V0C
10
?
A:
[3-813]
----------------
K
Y
N
P
H
A
I
E
A
K
W
Q
R
F
W
E
E
K
G
F
M
K
A
K
D
L
-
P
G
---
K
---
Q
Y
V
L
V
M
F
P
Y
P
S
G
D
L
H
M
G
H
L
K
N
Y
T
M
G
D
V
L
A
R
F
R
R
M
Q
G
Y
E
V
L
H
P
M
G
W
D
A
F
G
L
P
----
A
E
N
A
A
L
K
F
--------------------
G
----
V
H
-
P
----
K
----------
D
W
T
Y
A
----------
N
I
R
Q
A
K
--
E
S
L
-
R
L
M
G
I
L
Y
D
W
D
R
E
V
T
T
--
C
E
--
P
E
Y
Y
R
W
N
Q
W
-
I
F
L
K
M
W
E
K
G
L
A
Y
R
A
K
G
L
V
N
W
C
P
K
C
Q
T
V
L
A
N
E
Q
V
----------
V
--
E
G
R
CWRHED
T
P
V
E
K
R
------------------------
E
L
E
Q
W
Y
L
R
I
T
A
Y
A
E
R
L
L
K
D
LEGLNW
P
E
K
V
K
A
M
Q
R
A
W
I
G
R
S
E
G
A
E
I
L
F
P
V
E
G
K
E
V
R
I
P
V
F
T
T
R
--
P
D
T
L
F
G
A
T
F
L
V
L
A
P
E
H
P
L
T
L
E
L
A
----
A
----
P
EK
R
E
E
V
L
--
A
Y
V
E
A
A
K
R
K
T
E
I
-
E
-----
R
Q
A
E
--
G
R
E
--
K
T
G
V
F
L
G
A
Y
A
L
N
P
A
---
T
G
---
E
R
I
P
I
W
T
A
D
Y
V
L
F
G
Y
G
T
G
A
I
M
A
V
P
A
H
D
Q
R
D
Y
E
----------
F
----------
A
R
K
F
G
L
P
------
I
------
K
----
K
V
I
E
R
P
G
E
P
L
P
-----------------------
E
------------------
P
L
E
R
A
-
Y
E
E
P
G
-
I
M
V
-------
N
S
G
P
F
D
G
T
E
S
E
E
-------------------
G
K
R
K
V
I
A
W
L
---------
E
E
K
GL
G
K
-
G
R
V
T
---
Y
R
L
R
D
W
----
L
I
S
R
Q
R
Y
W
G
T
P
I
P
M
---
V
---
H
C
E
A
C
G
V
V
P
V
P
-
E
E
E
L
P
V
L
L
PDLK
D
V
ED
I
R
P
K
G
K
S
P
-
L
E
-
A
H
P
E
F
Y
---
E
T
T
C
P
K
C
G
-------------
G
P
A
K
R
----------
D
---
T
D
T
M
D
T
F
F
D
S
S
---------
W
Y
Y
L
R
-------------
Y
T
-----
D
---
P
HNDRLPFD
P
E
K
-----
A
N
A
--
W
M
---
P
V
D
Q
Y
I
G
G
V
E
H
------
A
V
L
H
L
L
Y
S
R
F
F
T
K
F
L
H
D
L
G
M
V
K
V
-
E
E
P
F
-
Q
G
L
F
T
Q
G
M
V
L
-------------------------
A
WTDF
G
P
V
E
V
E
GS
V
V
R
L
P
E
P
T
R
I
R
L
EIPESALS
L
E
D
V
R
K
M
G
A
E
L
R
P
H
E
D
G
T
L
H
L
W
K
P
A
------------------
V
M
S
K
S
K
G
N
G
V
M
V
G
P
F
V
K
E
Q
G
A
D
I
A
R
I
T
I
---
L
F
-
A
-
A
P
P
-
E
N
----
E
M
V
W
T
E
E
G
V
Q
G
-
A
W
-
R
F
L
N
R
I
Y
R
R
V
A
E
D
--
R
E
A
L
L
E
T
S
G
V
----
F
Q
A
E
A
L
E
G
K
D
R
E
L
Y
G
K
L
H
E
T
L
K
K
V
T
E
D
L
E
A
L
R
F
N
T
A
I
A
A
L
M
E
F
L
-
N
A
L
-
Y
E
Y
R
---
K
D
R
------------
P
V
T
P
V
Y
R
T
A
I
R
Y
Y
L
Q
M
L
F
P
F
A
P
H
L
A
E
E
L
W
H
W
F
W
----
P
-------
D
S
L
F
E
A
G
W
P
E
L
D
E
K
A
L
---
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.49
22%
-80
- C1 -
1WZ2
-
SYL_PYRHO
A:
[5-856]
------------------
N
F
K
A
I
E
E
K
W
Q
K
R
W
L
E
A
K
I
F
---
E
P
N
I
R
D
K
P
K
EK
K
F
Y
I
T
V
A
F
P
Y
L
S
G
H
L
H
V
G
H
A
R
T
Y
T
I
P
D
V
I
A
R
F
K
R
M
Q
G
Y
N
V
L
F
P
M
A
W
H
I
T
G
S
P
----
I
V
G
I
A
E
R
I
---
K
--
N
----
R
-------
D
P
----
K
T
-
I
----
W
I
Y
R
DVY
K
V
P
E
E
I
L
W
T
FED
P
I
N
I
V
K
Y
F
M
K
A
A
K
--
E
T
F
-
I
R
A
G
F
S
V
D
W
S
R
E
F
Y
T
T
S
L
F
--
P
P
F
S
K
F
I
E
W
-
Q
F
W
K
L
K
E
K
G
Y
I
V
K
G
A
H
R
V
R
W
D
P
V
V
G
T
P
L
G
D
H
D
L
----------
M
--
E
G
E
-----------
D
------------------------
V
P
I
L
D
Y
I
I
I
K
F
E
---------------
L
---------------------
R
E
N
G
E
V
I
Y
L
P
A
A
T
LR
P
E
T
V
Y
G
V
T
N
M
W
V
N
P
N
A
T
Y
V
K
A
K
V
R
R
KD
K
----
E
--
E
T
W
I
V
S
----
K
E
A
A
Y
K
L
S
F
-
Q
D
R
E
--
I
E
V
I
--
E
E
F
--
K
G
E
K
L
I
G
K
Y
V
R
N
P
V
---
S
G
---
D
E
V
I
I
L
P
A
E
F
V
D
P
D
N
A
T
G
V
V
M
S
V
P
A
H
A
P
F
D
H
V
ALEDL
K
R
E
T
E
I
----------
L
E
K
Y
D
I
D
P
R
I
VFP
A
------
V
----
E
E
V
N
K
L
G
I
K
S
Q
KDKEKLEQATK
T
I
Y
K
A
E
YHK
G
I
F
K
--
V
--
P
P
Y
E
G
K
P
V
Q
E
V
K
E
A
I
A
K
E
-
M
L
E
K
G
I
A
E
I
M
Y
-
E
F
A
E
K
N
V
I
S
R
F
-
G
N
R
A
V
I
K
I
I
H
D
Q
W
F
I
D
Y
GN
P
--
E
W
K
E
K
A
R
K
A
L
E
--
R
M
K
I
L
-
P
E
T
--
R
R
-
A
Q
F
E
A
I
I
----
D
W
LDKK
A
C
A
R
K
I
G
L
G
T
P
L
P
----
W
---
D
P
E
-
W
V
I
E
S
L
S
-
D
S
T
I
Y
M
A
Y
----
Y
T
--
I
S
R
H
I
N
K
L
---
R
Q
E
G
K
L
D
P
E
-
K
L
T
-
P
E
F
F
-----------
D
-
Y
I
F
L
E
----------
E
FSE
D
K
E
K
E
L
E
K
K
T
G
---------
I
P
A
E
I
-------------
I
H
-----
E
---
M
----------
K
-----
E
E
F
E
Y
W
Y
---
P
L
D
W
R
C
S
G
K
D
L
------
I
P
N
-----
H
L
T
F
F
I
F
N
H
V
A
I
F
-
R
-
E
E
H
W
P
K
G
I
A
V
N
G
F
G
--------------------------
T
----------------------------------------------
L
E
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
L
N
F
I
D
A
I
E
E
N
G
A
D
V
V
R
L
Y
I
---
M
S
-
L
A
E
-
H
-
D
S
----
D
F
---
D
W
R
R
K
E
-
V
G
-
K
L
R
K
Q
I
E
R
F
Y
E
L
I
---
S
Q
F
A
E
Y
E
V
K
G
-
N
V
----
E
L
K
D
I
D
R
W
M
L
H
R
L
N
K
A
I
K
E
T
T
N
A
L
E
E
F
R
T
R
T
A
V
Q
----------
W
A
F
Y
S
I
M
N
D
L
R
W
Y
L
R
R
T
E
G
R
D
D
E
A
K
R
Y
V
L
R
T
L
A
D
V
W
V
R
L
M
A
P
F
T
P
H
I
C
E
E
L
W
E
K
L
G
----------
G
E
G
F
V
S
L
A
K
W
P
E
P
V
E
E
W
W
N
E
T
I
E
A
E
E
E
F
I
R
S
V
M
E
D
I
K
E
I
I
E
V
A
K
I
E
---------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.44
25%
-
- C1 -
1IYW
-
SYV_THETH
A:
[2-776]
------------
D
L
P
K
A
Y
D
P
K
S
V
E
P
K
W
A
E
K
W
A
K
N
P
---
F
V
A
N
P
K
S
G
K
P
P
---
F
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
G
I
A
T
Q
V
V
V
E
R
L
L
L
K
E
---
G
K
-
T
----
R
-------
H
D
----
L
G
-
R
----
E
K
F
-----
L
E
R
V
W
Q
W
K
----------
E
E
S
G
G
T
I
L
K
Q
L
-
K
R
L
G
A
S
A
D
W
S
R
E
A
F
T
--
M
D
---
E
K
R
S
R
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
P
R
L
V
N
W
C
P
R
C
E
T
T
L
S
D
L
E
V
----------
E
--
T
E
P
-----------
T
-------------------------
P
G
K
L
Y
T
L
R
Y
E
V
E
G
-----------
G
G
F
---------------------
I
E
------
I
A
T
V
R
--
P
E
T
V
F
A
D
Q
A
I
A
V
H
P
E
-----------------
D
--
E
R
Y
-----------------------------
R
H
L
--
L
G
K
R
-----
A
R
I
P
L
---
T
E
---
V
W
I
P
I
L
A
D
P
A
V
E
K
D
F
G
T
G
A
L
K
V
T
P
A
H
D
P
L
D
Y
E
----------
I
----------
G
E
R
H
G
L
K
------
P
------
V
----
S
V
I
N
L
E
G
R
M
E
G
-----------------------
E
RV
P
--
E
A
L
R
G
L
D
R
F
E
A
R
R
K
A
V
E
L
-
F
R
E
A
G
-
H
L
V
K
E
-
E
D
Y
T
I
A
L
A
T
C
S
R
C
G
T
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
--
R
--
P
L
A
E
E
V
L
K
G
L
R
R
G
D
I
A
F
V
-
P
E
R
--
W
K
-
K
V
N
M
D
W
L
E
N
V
K
D
W
----
N
I
S
R
Q
L
W
W
G
H
Q
I
P
A
---
W
---
Y
C
E
-
D
C
Q
A
V
N
V
-
P
R
P
E
R
Y
L
E
----
D
---------------------
P
T
-
S
C
E
A
C
G
S
P
-----------
R
---
L
K
R
----------
D
---
E
D
V
F
D
T
W
F
S
S
A
---------
L
W
P
L
S
-------------
T
L
GWP--
E
---
E
----------
T
-----
E
D
L
K
A
F
Y
---
P
G
D
V
L
V
T
G
Y
D
I
------
L
F
L
-----
W
V
S
R
M
E
V
S
G
Y
H
F
M
-
G
-
E
R
P
F
-
K
T
V
L
L
H
G
L
V
L
-------------------------
D
----------------------------------------------
E
K
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
I
D
P
L
E
M
V
E
R
Y
G
A
D
A
L
R
F
------
A
-
L
-
I
-
Y
-
L
A
TGGQ
D
I
R
L
D
L
R
W
L
E
M
-
A
R
-
N
F
A
N
K
L
Y
N
A
A
R
F
V
--
L
L
S
R
E
G
F
Q
A
K
E
-
D
T
P
T
L
-----
A
D
R
F
M
R
S
R
L
S
R
G
V
E
E
I
T
A
L
Y
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
F
C
D
W
Y
L
E
A
A
K
P
A
L
K
A
G
N
A
-----
H
T
L
R
T
L
-
E
E
V
L
A
V
L
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
----
G
K
----
E
E
L
A
L
E
--------
A
W
P
E
P
G
G
R
D
E
E
A
E
R
----------
A
F
E
A
L
K
Q
A
V
T
A
V
R
A
L
K
A
E
A
G
L
P
P
A
Q
E
--
V
R
--
V
Y
L
E
G
ET
A
P
V
E
E
N
L
E
--------------------
V
F
R
F
L
S
R
A
D
L
L
P
E
R
P
A
------------------------------------------------------------
55
HHSearch
57.67
22%
-86
- C1 -
1WZ2
-
SYL_PYRHO
A:
[4-852]
-----------------
L
N
F
K
A
I
E
E
K
W
Q
K
R
W
L
E
A
K
I
F
E
P
N
I
R
D
K
P
K
E
K
K
---
F
Y
I
T
V
A
F
P
Y
L
S
G
H
L
H
V
G
H
A
R
T
Y
T
I
P
D
V
I
A
R
F
K
R
M
Q
G
Y
N
V
L
F
P
M
A
W
H
I
T
G
S
P
----
I
V
G
I
A
E
R
I
---
K
N
R
D
----
P
K
T
I
W
I
Y
R
D
V
----
Y
K
V
P
E
E
I
-
L
W
T
F
---
E
D
P
I
N
I
V
K
Y
----------
F
M
K
A
A
K
--
E
T
F
-
I
R
A
G
F
S
V
D
W
S
R
E
F
Y
T
--
T
S
LF
P
P
F
S
K
F
I
E
W
-
Q
F
W
K
L
K
E
K
G
Y
I
V
K
G
A
H
R
V
R
W
D
P
V
V
G
T
P
L
G
D
H
D
L
----------
M
--
E
G
E
-----------
D
V
P
----------------------
I
L
D
Y
I
I
I
K
F
E
L
R
E
N
-----------
G
-------------------------
E
V
I
Y
L
P
A
A
T
L
R
--
P
E
T
V
Y
G
V
T
N
M
W
V
N
P
N
A
T
Y
V
K
A
K
V
R
R
KD
K
----
E
--
E
T
W
I
V
S
K
E
A
A
Y
K
L
S
F
Q
-
D
--
R
--
E
--
I
E
V
I
--
E
E
F
--
K
G
E
K
L
I
G
K
Y
V
R
N
P
V
---
S
G
---
D
E
V
I
I
L
P
A
E
F
V
D
P
D
N
A
T
G
V
V
M
S
V
P
A
H
A
P
F
D
H
V
----------
A
LEDL
K
R
E
T
E
I
L
E
K
Y
D
I
D
------
P
R
I
V----FPAV
E
E
V
N
K
L
G
I
K
S
Q
KDKEKLEQATK
T
I
Y
K
A
E
YHK
G
I
F
K
--
V
--
P
P
Y
E
G
K
P
V
Q
E
V
K
E
A
I
A
K
E
-
M
L
E
K
G
-
I
A
E
I
M
-
Y
E
F
A
E
K
N
V
I
S
R
F
G
N
R
A
V
I
K
I
I
H
D
Q
W
F
I
D
Y
--
G
N
P
E
W
K
E
K
A
R
K
A
L
E
--
R
M
K
I
L
-
P
E
T
--
R
R
-
A
Q
F
E
A
I
I
D
W
L
D
K
K
----
A
C
A
R
K
I
G
L
G
T
P
L
P
W
---
D
PE
W
V
I
E
-
S
---
L
S
--------------------
D
S
T
I
Y
M
A
Y
Y
T
I
S
-
R
H
I
N
K
-
L
R
Q
---
E
G
-----------
K
L
D
P
E
K
L
----------
T
---
P
E
F
F
D
Y
I
F
L
E
E
---------
F
S
E
D
K
E
K
E
L
E
KKTGIP
A
E
I
I
-----
H
E
M
K
E
----------
E
-----
F
E
Y
--
W
Y
---
P
L
D
W
R
C
S
G
K
D
L
------
I
P
N
-----
H
L
T
F
F
I
F
N
H
V
A
I
F
-
R
E
E
H
W
P
-
K
G
I
A
V
N
G
F
G
T
------------------------------------------------------------------------
L
E
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
L
N
F
I
D
A
I
E
E
N
G
A
D
V
V
R
L
Y
I
---
M
S
-
L
-
A
-
E
H
D
S
----
D
F
D
W
R
R
K
E
V
G
K
-
L
R
-
K
Q
I
E
R
F
Y
E
L
I
S
Q
F
--
A
E
Y
E
--
V
K
-------
G
N
V
E
L
K
D
I
D
R
W
M
L
H
R
L
N
K
A
I
K
E
T
T
N
A
L
E
E
F
R
T
R
T
A
V
Q
W
A
F
Y
S
I
M
N
D
L
-
R
W
Y
L
R
R
T
E
G
R
D
---------
D
E
A
K
R
Y
V
L
R
T
L
A
D
V
W
V
R
L
M
A
P
F
T
P
H
I
C
E
E
L
W
E
K
L
G
----
G
------
E
G
F
V
S
L
A
K
W
P
E
P
V
E
E
W
W
N
E
T
I
E
A
E
E
E
F
I
R
S
V
M
E
D
I
K
E
I
I
E
V
-------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.52
23%
-88
- C1 -
4ARI
4
SYL_ECOLI
A:
[31-796]
-----------------------
E
S
K
V
Q
L
H
W
D
E
K
R
T
F
E
V
T
E
D
E
S
K
E
--
K
---
Y
Y
C
L
S
M
L
P
Y
P
S
G
R
L
H
M
G
H
V
R
N
Y
T
I
G
D
V
I
A
R
Y
Q
R
M
L
G
K
N
V
L
Q
P
I
G
W
D
A
F
G
L
P
----
A
E
G
A
A
V
K
N
---
N
T
A
P
------------------------------------
A
P
W
T
Y
D
----------
N
I
A
Y
M
K
--
N
Q
L
-
K
M
L
G
F
G
Y
D
W
S
R
E
L
A
T
--
C
T
--
P
E
Y
Y
R
W
E
Q
K
-
F
F
T
E
L
Y
K
K
G
L
V
Y
K
K
T
S
A
V
---------------E
I
P
Q
W
F
I
KIT
A
--
Y
A
D
-----------
E
L
L
N
D
L
DKLDHWP
D
T
V
K
T
M
Q
R
N
W
I
G
R
S
E
G
V
E
I
T
F
N
V
N
D
Y
-----------
D
N
T
---------------------
L
------
T
V
Y
T
T
R
--
P
D
T
F
---
M
G
C
T
------
Y
L
A
V
A
A
----
G
----
H
--
P
---
L
A
Q
K
A
A
E
N
N
P
E
L
A
A
F
I
D
--
E
--
C
R
N
T
-----E
K
K
G
V
D
-
T
G
F
K
A
V
H
P
L
---
T
G
---
E
E
I
P
V
W
A
A
N
F
V
L
M
E
Y
G
T
G
A
V
M
A
V
P
G
H
D
Q
R
D
Y
E
----------
F
----------
A
S
K
Y
G
L
N
------
I
----------------
K
P
V
I
L
A
-----------------------
A
-------------
D
G
S
E
P
D
L
S
Q
Q
A
L
T
E
K
G
-
V
L
F
N
S
G
E
F
--
N
G
L
D
H
E
------
A
A
F
N
A
I
A
---------------
D
K
L
T
A
M
G
--
V
----------
G
E
-
R
K
V
N
Y
R
L
R
---
D
W
----
G
V
S
R
Q
R
Y
W
G
A
P
I
P
M
---
V
---
T
L
E
-
D
G
T
V
M
P
T
P
D
D
Q
L
P
V
I
L
---------------------
P
E
D
V
V
M
D
-
G
I
T
S
P
I
K
A
-----------
D
-
P
E
W
A
K
T
T
V
NG
M
P
A
L
R
E
---
T
D
T
F
D
T
F
M
E
S
S
W
Y
Y
A
R
Y
T
C
P
Q
Y
K
E
G
-------------
M
L
-----
D
S
--
E
----------
A
-----
A
N
Y
--
W
L
---
P
V
D
I
Y
I
G
G
I
E
H
AIM
H
L
L
Y
F
R
-----
F
F
H
K
L
M
R
D
A
G
M
V
N
-
S
-
D
E
P
A
-
K
Q
L
L
C
Q
G
M
V
L
A
D
A
F
Y
Y
V
G
ENG
E
R
N
W
V
S
PVD
A
I
V
E
R
D
----------------------------------------------
E
K
G
-------
R
IV
K
A
K
D
AAG
H
E
L
V
Y
TGMS
K
M
S
K
S
K
N
N
G
I
D
P
Q
V
M
V
E
R
Y
G
A
D
T
V
R
L
F
M
M
F
A
S
P
-
A
-
D
-
M
-
T
L
----
E
W
Q
E
S
G
------
V
E
-
G
A
N
R
F
L
K
R
V
W
K
L
V
--
Y
E
H
T
A
K
G
D
--
V
-
A
A
L
N
V
D
A
L
T
E
N
Q
K
A
L
R
R
D
V
H
K
T
I
A
K
V
T
D
-------
D
I
G
R
R
Q
T
F
N
T
A
I
A
A
I
M
E
L
M
N
K
L
A
K
A
P
T
D
G
E
Q
----
D
R
A
L
M
Q
----
E
A
L
L
A
V
V
R
M
L
N
P
F
T
P
H
I
C
F
T
L
W
Q
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
57.10
22%
-86
- C1 -
1WKB
8
SYL_PYRHO
A:
[4-810]
-----------------
L
N
F
K
A
I
E
E
K
W
Q
K
R
W
L
E
A
K
I
F
E
P
N
I
R
D
K
P
K
E
K
K
---
F
Y
I
T
V
A
F
P
Y
L
S
G
H
L
H
V
G
H
A
R
T
Y
T
I
P
D
V
I
A
R
F
K
R
M
Q
G
Y
N
V
L
F
P
M
A
W
H
I
T
G
S
P
----
I
V
G
I
A
E
R
I
---
K
N
R
D
----
P
K
T
I
W
I
Y
R
D
V
----
Y
K
-
V
P
E
E
I
L
W
T
F
---
E
D
P
I
N
I
V
K
Y
----------
F
M
K
A
A
K
--
E
T
F
-
I
R
A
G
F
S
V
D
W
S
R
E
F
Y
T
--
T
S
LF
P
P
F
S
K
F
I
E
W
-
Q
F
W
K
L
K
E
K
G
Y
I
V
K
G
A
H
R
V
R
W
D
P
V
V
G
T
P
L
G
D
H
D
L
----------
M
--
E
G
E
-----------
D
V
P
----------------------
I
L
D
Y
I
I
I
K
F
E
L
R
E
N
-----------
G
-------------------------
E
V
I
Y
L
P
A
A
T
L
R
--
P
E
T
V
Y
G
V
T
N
M
W
V
N
P
N
A
T
Y
V
K
A
K
V
----
R
R
KD
K
E
--
E
T
W
I
V
S
K
E
A
A
Y
K
L
S
F
Q
D
---
R
--
E
--
I
E
V
I
--
E
E
F
--
K
G
E
K
L
I
G
K
Y
V
R
N
P
V
---
S
G
---
D
E
V
I
I
L
P
A
E
F
V
D
P
D
N
A
T
G
V
V
M
S
V
P
A
H
A
P
F
D
H
V
A
L
E
D
L
K
R
E
TE
I
----------
L
E
K
Y
D
I
D
------
P
RIVFPA
V
----
E
E
V
N
K
L
G
I
K
S
Q
KDKEK
L
E
Q
A
T
K
T
I
Y
K
A
E
Y
H
K
G
I
F
K
--
V
--
P
P
Y
E
G
K
P
V
Q
E
V
K
E
A
I
A
K
E
-
M
L
E
K
G
-
I
A
E
I
M
-
Y
E
F
A
E
K
N
V
I
S
R
F
G
N
R
A
V
I
K
I
I
H
D
Q
W
F
I
D
Y
--
G
N
P
E
W
K
E
K
A
R
K
A
L
E
--
R
M
K
I
L
-
P
E
T
--
R
R
-
A
Q
F
E
A
I
I
D
W
L
D
K
K
----
A
C
A
R
K
I
G
L
G
T
P
L
P
W
DPE
W
---
V
I
E
S
L
S
D
------------------------
S
T
I
Y
M
A
Y
Y
T
I
S
-
R
H
I
N
--
K
L
--
R
Q
E
G
-----------
K
L
D
P
E
K
L
----------
T
---
P
E
F
F
D
Y
I
F
L
E
E
---------
F
S
E
D
K
E
K
E
L
E
K
K
T
GIP
A
E
I
I
-----
H
---
E
M
K
E
-------
E
-----
F
E
Y
--
W
Y
---
P
L
D
W
R
C
S
G
K
D
L
------
I
P
N
-----
H
L
T
F
F
I
F
N
H
V
A
I
F
R
E
-
E
H
W
P
-
K
G
I
A
V
N
G
F
G
T
------------------------------------------------------------------------
L
E
G
-------
Q
------------------
K
M
S
K
S
K
G
N
V
L
N
F
I
D
A
I
E
E
N
G
A
D
V
V
R
L
Y
I
---
M
S
-
L
-
A
-
E
H
D
S
----
D
F
D
W
R
R
K
E
V
G
K
-
L
R
-
K
Q
I
E
R
F
Y
E
L
I
S
Q
F
--
A
E
Y
E
----
V
K
-----
G
N
V
E
L
K
D
I
D
R
W
M
L
H
R
L
N
K
A
I
K
E
T
T
N
A
L
E
E
F
R
T
R
T
A
V
Q
W
A
F
Y
S
I
M
N
D
L
-
R
W
Y
L
R
R
T
E
G
R
D
---------
D
E
A
K
R
Y
V
L
R
T
L
A
D
V
W
V
R
L
M
A
P
F
T
P
H
I
C
E
E
L
W
E
K
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------