@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15480: (2016-06-24 )
MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMSPAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGLVYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYSLKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWFAVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHRSIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKISALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAFIQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI
Atome Classification :
(20 SA)
----------------------------------------------.........10......-.-..20........-30----..------......40---........50-------.........60..-......70........80---.......---..90--........-.100.....---..110.-.....--.120.....--------..130......--.140.....--..150--.....-----...160.......170.......180.-----.....----.-190.......200-.........210.-------.....--.220.......230.---.......240.......250.......260-----------........270-........280.--......290.-------------------......-300..----------....--.----310----.....-------...320..----.....330---.....-....340----......-...350--.--.-----.....-----------..360-------.........370.......380.......390.......400.......410.......----420----.......430...--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------MSK
K
K
VNLGV-RDVPT
P
-
F
-
S
W
V
S
F
S
L
Q
H
L
F
A
-
M
F----GS------
T
I
L
V
P
K
LV---GMS
P
A
V
A
L
V
--------
T
S
G
I
G
T
L
A
Y
L
L
I
T-KGQ
I
P
A
Y
LGS
S
F
A
F
I
S
P
----
I
I
L
V
K
AT---GGP---
G
A
A
M
V
G
A
F
-
L
A
G
L
V
Y
G
L
I
---
A
L
L
I
R
Q-LG
T
G
W
--
L
M
K
IL
P
P
VV--------VG
P
V
I
I
V
I
GL
G
--
L
A
S
T
A
V
N
M
A
--
M
YAD---P
N
A
S
E
-----
L
V
Y
S
L
K
HFSVA
G
V
T
L
A
I
T
I
I
C
A
I
F
L
R
G
-----
F
L
S
L
I
----
P
-
V
L
I
G
I
I
G
G
Y
L
F
---
A
L
T
Q
G
I
VNFQPVL-------DAKWF--AV
P
E
F
I
I
PFKDYS-P---S
V
T
L
G
I
A
A
A
M
V
P
V
A
F
V
T
M
S
E
HI
G
H
Q
M
V
L
S
------------
K
V
V
G
Q
D
F
I
KK--PGL
H
R
S
I
MG
D
S
V
--
A
T
I
L
A
S
L
IGG-------------------PPTTTY-GEN
I
G
----------
V
L
A
I
--
T
----
R
V
-----
F
S
V
F
V-------I
G
G
A
A
V
I
A
----
L
C
F
G
F
I
-----
G
K
I
S
A
-
L
I
S
S
V
------
P
S
A
V
M
G
-
G
V
S
F
----
L
--
L
-----
F
G
I
I
A
-----------SSG---------
L
R
M
L
IDNKIDYENNR
N
L
I
I
T
S
V
I
L
V
I
GVG
G
A
F
I
Q
V
SQG
G
F
Q
V
S
G
M
A
L
A
A
I
V
G
V
I
L
N
L
IL----PQA----KEEQADTSEQHHI--------
29
Fugue
79.41
45%
-159
- C4 -
3QE7
2
URAA_ECOLI
A:
[4-410]
---------------------------------------------------
R
A
I
G
V
-
S
E
R
P
P
L
-
L
-
Q
T
I
P
L
S
L
Q
H
L
F
A
-
M
F
----
G
A
------
T
V
L
V
P
V
L
F
---
H
I
N
P
A
T
V
L
L
--------
F
N
G
I
G
T
L
L
Y
L
F
I
C
-
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
----
V
L
L
L
L
P
L
---
G
-
Y
---
E
V
A
L
G
G
F
I
-
M
C
G
V
L
F
C
L
V
---
S
F
I
V
K
K
-
A
G
T
G
W
--
L
D
V
L
F
P
P
A
A
--------
M
G
A
I
V
A
V
I
G
L
E
--
L
A
G
V
A
A
G
M
A
--
G
L
L
P
---
A
E
G
Q
T
-------
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
-----
F
L
A
I
I
----
P
-
I
L
I
G
V
L
V
G
Y
A
L
---
S
F
A
M
G
I
V
D
T
T
P
I
I
-------
N
A
H
W
F
--
A
L
P
T
L
------
Y
T
-
P
---
R
F
E
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
------------
N
I
V
K
K
D
L
L
R
D
--
P
G
L
H
R
S
M
F
A
N
G
L
--
S
T
V
I
S
G
F
F
G
S
-------------------
T
P
N
T
T
Y
-
G
E
N
I
G
----------
V
M
A
I
--
T
----
R
V
-----
Y
S
T
W
V
-------
I
G
G
A
A
I
F
A
----
I
L
L
S
C
V
-----
G
K
L
A
A
-
A
I
Q
M
I
------
P
L
P
V
M
G
-
G
V
S
L
----
L
--
L
-----
Y
G
V
I
G
-----------
A
S
G
---------
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
K
V
N
I
--
G
A
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
----
K
L
I
----
S
--------------------
19
HHSearch
78.46
44%
-157
- C4 -
3QE7
2
URAA_ECOLI
A:
[4-410]
---------------------------------------------------
R
A
I
G
V
-
S
E
R
P
P
L
-
L
-
Q
T
I
P
L
S
L
Q
H
L
F
A
-
M
F
----
G
A
------
T
V
L
V
P
V
L
F
---
H
I
N
P
A
T
V
L
L
--------
F
N
G
I
G
T
L
L
Y
L
F
-
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
----
V
L
L
L
L
-
P
---
L
G
Y
---
E
V
A
L
G
G
F
I
-
M
C
G
V
L
F
C
L
V
---
S
F
-
I
V
K
K
A
G
T
G
W
--
L
D
V
L
F
P
P
A
A
--------
M
G
A
I
V
A
V
I
G
L
E
--
L
A
G
V
A
A
G
M
A
--
G
L
L
P
---
A
E
--
G
-----
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
-----
F
L
A
I
I
----
P
-
I
L
I
G
V
L
V
G
Y
A
L
---
S
F
A
M
G
I
V
D
T
T
P
I
I
-------
N
A
H
W
F
--
A
L
P
T
L
Y
------
T
-
P
---
R
F
E
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
------------
N
I
V
K
K
D
L
L
R
D
--
P
G
L
H
R
S
M
F
A
N
G
L
--
S
T
V
I
S
G
F
F
G
S
-------------------
T
P
N
T
T
Y
-
G
E
N
I
G
----------
V
M
A
I
--
T
----
R
V
-----
Y
S
T
W
V
-------
I
G
G
A
A
I
F
A
----
I
L
L
S
C
V
-----
G
K
L
A
A
-
A
I
Q
M
I
------
P
L
P
V
M
G
-
G
V
S
L
----
L
--
L
-----
Y
G
V
I
G
-----------
A
S
G
---------
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
K
V
N
I
--
G
A
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
----
K
L
I
----
S
--------------------
1
PsiBlast_PDB
76.71
42%
-158
* C4 *
3QE7
2
URAA_ECOLI
A:
[4-410]
-------------------------------------------------
R
A
I
--
G
V
-
S
E
R
P
P
L
-
L
-
Q
T
I
P
L
S
L
Q
H
L
F
A
-
M
F
----
G
A
------
T
V
L
V
P
V
L
F
---
H
I
N
P
A
T
V
L
L
--------
F
N
G
I
G
T
L
L
Y
L
F
I
C
-
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
----
V
L
L
L
L
P
L
---
G
Y
E
----
V
A
L
G
G
F
I
-
M
C
G
V
L
F
C
L
V
---
S
F
I
V
K
K
-
A
G
T
G
W
--
L
D
V
L
F
P
P
A
A
--------
M
G
A
I
V
A
V
I
G
L
E
--
L
A
G
V
A
A
G
M
A
GL
L
P
A
E
GQT
P
D
S
K
T
-----
I
I
I
S
I
T
-------
T
L
A
V
T
V
L
G
S
V
L
F
R
G
-----
F
L
A
I
I
----
P
-
I
L
I
G
V
L
V
G
Y
A
L
---
S
F
A
M
G
I
V
D
T
T
P
I
I
-------
N
A
H
W
F
--
A
L
P
T
L
Y
T
P
R
F
E
W
F
-
A
---
I
L
T
I
------
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
------------
N
I
V
K
K
D
L
L
R
D
--
P
G
L
H
R
S
M
F
A
N
G
L
--
S
T
V
I
S
G
F
F
G
S
-------------------
T
P
N
T
T
Y
-
G
E
N
I
G
----------
V
M
A
I
--
T
----
R
V
-----
Y
S
T
W
V
-------
I
G
G
A
A
I
F
A
----
I
L
L
S
C
V
-----
G
K
L
A
A
-
A
I
Q
M
I
------
P
L
P
V
M
G
-
G
V
S
L
----
L
--
L
-----
Y
G
V
I
G
-----------
A
S
G
---------
I
R
V
L
I
E
S
K
V
D
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
--
K
V
N
I
G
A
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
L
I
F
K
LIS----------------------------
30
Fugue
42.98
20%
-163
* C6 *
4P6V
2
NQRB_VIBCH
B:
[38-409]
------------------------------------------------------
G
L
-
V
T
K
R
S
S
-
H
-
V
R
D
S
V
D
L
K
R
I
M
I
-
M
V
----
W
L
------
A
V
F
P
A
M
F
W
---
G
M
Y
N
A
G
G
Q
A
--------
I
A
A
L
N
H
L
-------------
Y
S
G
D
Q
L
A
A
I
V
A
G
N
W
H
Y
W
L
T
E
M
L
---
G
G
T
---
M
G
S
--
K
M
L
-
L
G
A
T
Y
F
L
P
I
---
Y
A
T
V
F
I
-
V
G
G
F
W
E
V
L
F
C
M
V
R
K
H
E
--------
V
N
E
-------
G
--
F
F
V
T
S
I
L
F
A
--
L
I
V
P
---
P
T
L
P
-----------
L
W
Q
A
A
L
G
I
T
F
G
V
V
V
A
K
E
V
F
G
G
T
-----
G
R
N
F
L
----
N
-
P
A
L
A
G
R
A
F
L
F
F
---
A
Y
P
A
Q
I
S
G
------------
D
L
V
W
T
--
A
A
D
-------
G
Y
S
-
G
---
A
T
A
L
S
Q
W
A
Q
G
G
A
G
A
L
I
N
I
P
G
S
I
G
E
V
S
T
L
A
------------
L
M
I
G
A
A
F
I
V
Y
--
M
G
I
--------------------
A
-------------------
S
W
R
I
I
G
-
G
V
M
I
G
----------
M
I
L
L
--
S
----
T
L
-----
F
N
V
I
G
-------
S
D
T
N
A
M
F
N
----
M
P
W
H
L
--------------------------
V
L
G
-
G
F
A
F
----
G
--
M
-----
F
-
F
M
A
-----------
T
D
P
---------
V
S
A
S
F
T
N
S
G
K
W
A
Y
G
I
L
I
G
V
M
C
V
L
I
R
V
-
V
N
P
A
Y
P
E
---------
G
M
M
L
A
I
L
F
---
A
N
L
F
A
----
P
L
F
----
D
H
V
V
V
E
R
N
I
K
R
R
L
--------
32
Fugue
42.00
12%
-174
* C5 *
3FGA
1
2A5G_HUMAN
B:
[1-403]
----------------------------------------------
P
P
A
D
Q
E
K
L
F
I
-
Q
K
L
R
Q
C
-
C
-
V
L
F
D
F
V
S
D
P
L
S
D
-
L
K
----
W
K
------
E
V
K
R
A
A
L
S
---
E
M
V
E
Y
I
T
H
N
--------
R
N
V
I
T
E
P
I
Y
P
E
V
V
-
H
M
F
A
V
N
M
F
R
T
L
P
P
S
S
N
P
----
T
G
A
E
F
D
P
---
E
E
D
---
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
---
L
R
F
L
E
S
---
P
D
F
--
Q
P
N
I
A
K
K
Y
----------------
I
D
Q
K
--
F
V
L
Q
L
L
E
L
F
--
D
S
E
D
---
P
R
E
R
D
-----
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
Q
I
N
N
I
-----
F
Y
R
F
I
----
Y
-
E
---------------
T
E
H
H
N
G
I
A
E
L
L
-------
E
I
L
G
S
--
I
I
N
G
F
A
L
P
L
K
E
E
H
-
K
---
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
-----
Y
H
P
Q
L
A
------------
Y
C
V
V
Q
F
L
E
K
D
--
S
T
L
T
E
P
V
V
M
A
L
L
--
K
Y
W
--------------------------
P
K
T
H
S
P
-
K
E
V
M
F
----------
L
N
E
L
--
E
----
E
I
-----
L
D
V
---------
I
E
P
S
E
F
V
K
----
I
M
E
P
L
F
-----
R
Q
L
A
K
-
C
V
S
S
P
------
H
F
Q
V
A
E
-
R
A
L
Y
----
Y
--
W
NN
E
Y
I
M
S
L
I
S
D
N
---------
A
A
K
---------
I
L
P
I
M
F
P
S
L
Y
R
N
S
K
T
H
W
N
K
T
I
H
G
L
I
Y
N
A
L
K
L
F
M
E
M
N
Q
K
L
F
--
D
D
C
T
Q
Q
F
K
A
E
K
L
K
E
K
L
K
----
M
K
E
----
R
E
E
A
W
V
K
I
E
N
L
----------
31
Fugue
41.59
15%
-160
- C2 -
2IVN
3
KAE1_PYRAB
A:
[1-325]
-----------------------------------------------------------------------------------------------------------
M
L
A
L
G
I
--------
E
G
T
A
H
T
L
G
I
G
I
V
S
-
E
D
K
V
L
A
N
V
F
D
T
L
T
------------
T
E
K
---
G
G
I
---
H
P
K
E
A
A
E
H
-
H
A
R
L
M
K
P
L
L
---
R
K
A
L
S
E
-
A
G
---------
V
S
L
D
D
--------
I
D
V
I
A
F
S
Q
G
P
G
--
L
G
P
A
L
R
V
V
A
--
T
A
A
R
---
A
L
A
V
K
----------
Y
R
K
P
I
V
G
V
N
H
C
I
A
H
V
E
I
T
K
M
F
G
-----
V
K
D
P
V
----
G
-
L
Y
V
S
G
G
N
T
Q
V
L
---
A
L
E
G
G
-----------------------------
R
Y
R
V
F
G
-
E
---
T
L
D
I
G
I
G
N
A
I
D
V
F
A
R
E
L
G
L
G
F
P
G
G
P
K
V
E
K
------------
L
A
E
K
G
E
--
K
Y
--
I
E
L
P
Y
A
V
K
G
M
D
L
SF
S
G
L
L
T
E
A
I
R
K
-------------------
Y
R
S
G
K
Y
R
V
E
D
L
A
----------
Y
S
F
Q
--
E
----
T
A
-----
F
A
A
L
V
-------
E
V
T
E
R
A
V
A
----
H
T
------------------
E
K
------
D
E
V
V
L
V
-
G
-----------------
G
V
A
A
-----------
N
N
R
---------
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
P
P
Y
D
L
C
R
-----------------
D
N
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
----
I
S
F
----
R
L
E
E
T
I
V
K
Q
K
F
R
T
DEVEIVWH
20
HHSearch
40.93
15%
-147
- C4 -
5DA0
2
?
A:
[14-346]
------------------------------------------------------
Q
R
-
E
W
F
A
N
P
-
R
-
K
D
V
L
A
G
I
V
V
A
L
A
-
L
I
----
P
E
------
A
I
A
F
S
I
I
A
---
G
V
D
P
Q
V
G
L
Y
--------
A
S
F
I
I
A
L
I
T
A
F
-
L
-
G
G
R
P
G
M
I
S
A
A
T
G
A
M
A
L
L
----
M
T
G
L
V
K
D
---
H
G
I
---
Q
Y
L
F
A
A
T
V
-
L
T
G
V
L
Q
V
V
F
---
G
W
-----
A
K
L
A
R
--
Y
L
K
F
V
P
R
S
V
--------
M
V
G
F
V
N
A
L
A
I
L
--
I
F
M
A
Q
L
P
Q
F
--
V
G
A
N
---
W
--------------
Q
M
Y
A
M
V
A
A
G
L
A
I
I
Y
L
L
P
L
V
---------
F
K
A
M
----
P
S
A
L
V
A
I
V
V
L
T
V
V
---
A
V
V
T
G
A
-
D
V
K
T
V
G
-------
D
M
G
T
L
PT
A
L
P
H
F
Q
F
P
Q
-
V
P
L
T
F
---
E
T
L
A
I
I
F
P
V
A
L
T
L
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
------------
E
R
T
D
----
T
T
--
S
D
K
N
V
E
S
R
G
Q
G
V
--
A
N
I
V
T
G
F
F
G
G
-------------------
M
A
G
C
A
M
I
G
Q
S
M
-----------
I
N
V
T
--
S
----
G
G
-----
R
G
R
L
S
-------
T
F
V
A
G
A
F
L
----
M
V
L
I
L
A
-------
L
Q
P
-
L
L
V
Q
I
------
P
M
A
A
L
V
-
A
V
M
M
----
V
-------------------------
V
A
---------
I
S
T
F
D
W
-------------------------------------------------------------------------------------
38
Fugue
40.76
13%
-193
- C5 -
2W3C
3
USO1_HUMAN
A:
[3-577]
LEV
G
I
Q
A
M
E
H
L
I
H
V
L
Q
TDRSD
S
E
I
I
G
Y
A
L
D
T
L
Y
N
I
I
S
NS
Q
F
T
E
I
F
I
K
Q
Q
E
N
V
T
L
L
L
-
S
L
L
E
E
F
D
F
-
H
V
R
W
P
G
V
K
L
L
T
S
-
L
L
----
K
Q
L
G
P
Q
V
Q
Q
I
I
L
V
S
P
M
---
G
V
S
R
L
M
D
L
L
A
DSR
E
V
I
R
N
D
G
V
L
L
L
Q
A
L
T
R
S
-
N
G
A
I
Q
K
I
V
A
F
E
N
A
F
E
R
L
----
L
D
I
I
S
E
E
---
G
N
S
---
D
G
G
I
V
V
E
D
-
C
L
I
L
L
Q
N
L
L
KNN
N
S
N
Q
N
F
-
F
K
E
G
S
--
Y
I
Q
R
M
K
P
W
F
--------
E
V
G
W
S
A
Q
K
V
T
N
--
L
H
L
M
L
Q
L
V
R
--
V
L
V
S
---
P
T
N
P
P
-----
G
A
T
S
S
C
Q
K
A
M
F
Q
C
G
L
L
Q
Q
L
C
T
I
L
M
A
T
G
-----
V
P
A
D
I
----
L
-
T
E
T
I
N
T
V
S
E
V
I
RGC
Q
V
N
Q
D
Y
F
A
S
V
N
A
P
-------
S
P
P
R
P
--
A
I
V
V
L
L
M
S
M
V
N
E
R
-
Q
---
P
F
V
L
R
C
A
V
L
Y
C
F
Q
C
F
L
Y
K
N
Q
K
G
Q
G
E
I
V
S
T
L
L
PSTIDATGNS
V
S
A
G
Q
L
L
C
G
G
--
L
F
S
T
D
S
L
S
N
W
C
A
--
A
V
A
L
A
H
A
L
Q
E
N
A
T
Q
K
E
Q
L
L
R
V
Q
L
A
T
S
I
G
N
P
P
V
S
L
L
-
Q
Q
C
T
N
I
L
S
QGSK
I
Q
T
R
V
G
L
--
L
----
M
L
-----
L
C
T
W
L
-------
S
N
C
P
I
A
V
T
----
H
F
L
H
N
S
-----
A
N
V
P
F
-
L
T
G
Q
I
A
E
N
L
G
E
E
E
Q
L
V
Q
-
G
L
C
A
----
L
--
L
-----
L
G
I
S
I
Y
F
NDNSLESYM
K
E
K
---------
L
K
Q
L
I
E
K
R
I
G
K
E
N
F
I
E
K
L
G
F
-----
I
S
K
H
E
L
Y
S
R
A
S
Q
K
P
Q
P
N
F
P
S
P
E
Y
M
I
F
D
H
E
F
T
K
L
V
----
K
E
L
----
E
G
V
I
T
K
A
I
Y
------------
35
Fugue
38.06
20%
-133
- C5 -
4MUO
-
YBIB_ECOLI
A:
[1-320]
----------------------------------------------
M
D
Y
R
K
I
I
K
E
I
G
R
G
K
N
H
A
-
R
-
D
L
D
R
D
T
A
R
G
L
Y
A
H
M
L
----
N
G
------
E
V
P
D
L
E
L
G
---
G
V
L
I
A
L
R
I
K
--------
G
E
G
E
A
E
M
L
G
F
Y
E
A
-
M
Q
N
H
T
I
K
L
T
P
P
A
G
K
P
M
P
----
I
V
I
P
S
Y
N
---
G
A
R
---
K
Q
A
N
L
---------
T
P
L
L
---
A
I
L
L
H
K
-
L
G
---------
F
P
V
V
V
--------
H
G
V
S
----------------------
E
D
---
P
T
R
--------
V
L
T
E
T
I
F
E
L
M
G
I
T
---------------------------
P
-
T
L
--------------------
H
G
G
Q
A
-------
Q
A
K
L
D
--
E
H
Q
P
V
F
M
P
V
G
A
F
C
-
P
---
P
L
E
K
Q
L
A
----------
M
R
W
R
M
G
V
R
--------------------------------------
N
S
--
A
H
T
L
A
K
L
A
------------------------
T
P
F
-
A
E
G
--------------
E
A
--
L
----
R
L
-----
S
S
V
S
H
-------
P
E
Y
I
G
R
V
A
----
K
F
F
S
D
I
-----
G
G
R
A
L
-
L
M
H
G
T
------
E
G
E
V
Y
A
N
P
Q
R
C
----
P
--
Q
-----
I
N
L
I
D
-----------
R
E
G
---------
M
R
V
L
Y
E
K
Q
A
K
D
P
E
T
T
A
Q
W
I
E
R
C
L
--------------
A
G
S
E
P
I
P
E
S
L
K
I
Q
M
A
C
C
L
V
A
T
G
----
E
A
A
----
T
I
S
D
G
L
A
R
V
N
Q
A
F
--------
33
Fugue
34.70
10%
-166
- C4 -
2JLN
2
?
A:
[8-470]
----------------------------------------------
E
A
R
S
L
L
N
P
S
N
-
A
P
T
R
Y
A
-
E
R
S
V
G
P
F
S
L
A
A
I
W
F
-
A
M
A
IQ
V
A
I
------
F
I
A
A
G
Q
M
T
S
S
F
Q
V
W
Q
V
I
V
A
I
--------
A
A
G
C
T
I
A
V
I
L
L
F
F
-
T
Q
S
A
A
I
R
W
G
I
N
F
T
V
A
A
R
----
M
P
F
-
G
I
R
---
G
S
L
---
I
P
I
T
L
K
A
L
-
L
S
L
F
W
F
G
F
Q
---
T
W
L
G
A
L
-
A
L
D
E
I
--
T
R
L
L
T
-------------
G
F
T
N
L
P
L
W
I
V
--
I
F
G
A
I
Q
V
V
T
--
T
F
Y
G
---
I
T
F
I
R
-----
W
M
N
V
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
-----
S
L
G
E
V
----
M
-
S
M
G
G
--
E
N
P
G
M
---
P
F
S
T
A
I
M
I
F
V
G
G
W
-------
I
A
V
V
V
--
S
I
H
D
I
V
K
E
C
K
V
D
P
-
N
AS
R
E
G
Q
T
K
A
D
A
R
Y
A
T
A
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
G
------------
A
A
S
M
V
L
V
G
E
W
N
P
V
I
A
I
T
E
V
V
G
G
V
S
--
I
P
M
A
I
L
F
Q
V
F
-------------------
V
L
L
A
T
W
-
S
T
N
P
A
----------
A
N
L
L
--
S
----
P
A
-----
Y
T
L
C
S
T
F
P
RVFT
F
K
T
G
V
I
V
S
----
A
V
V
G
L
L
-----
M
M
P
W
Q
-
F
A
G
V
L
------
N
T
F
L
N
L
-
L
A
S
A
----
L
G
P
L
-----
A
G
I
M
I
-----------
S
D
Y
FLVRRRRIS
L
H
D
L
Y
R
T
K
G
I
Y
T
Y
W
R
G
V
N
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
T
P
D
L
M
F
V
T
G
L
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
----
K
T
F
----
P
L
F
S
E
A
E
S
R
N
E
D
Y
L
RPIG---
28
HHSearch
34.01
0%
-358
* C7 *
4B19
-
?
A:
[9-24]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
V
I
S
G
C
A
I
A
F
F
S
Y
W
L
---------------------------------
12
PsiBlast_PDB
34.01
24%
-96
- C7 -
4EY8
2
ACES_HUMAN
A:
[240-409]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
-------------------
P
-------
N
D
T
E
----------
L
V
A
C
L
R
T
----
R
P
-----
A
Q
V
L
V
-------
N
H
E
W
H
V
L
P
QESV
F
R
F
S
F
V
-----
P
V
V
D
G
D
F
L
S
D
T
------
P
E
A
L
I
N
-
A
G
D
F
H
G
L
Q
V
--
L
-----
V
G
V
V
K
-----------
D
E
G
---------
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
-------
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
----
P
E
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
--------
6
PsiBlast_PDB
33.87
24%
-92
- C7 -
1B41
1
ACES_HUMAN
A:
[237-405]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
-------------------
P
-------
N
D
T
E
----------
L
V
A
C
L
R
T
----
R
P
-----
A
Q
V
L
V
-------
N
H
E
W
H
V
L
P
Q
E
S
V
F
R
F
S
F
V
-----
P
V
V
D
G
D
F
L
S
D
T
------
P
E
A
L
I
N
-
A
G
D
F
HG
L
Q
V
--
L
-----
V
G
V
V
K
-----------
D
E
G
---------
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
-------
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
----
P
E
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
--------
21
HHSearch
33.76
15%
-147
- C4 -
4YZF
1
B3AT_HUMAN
A:
[436-802]
----------------------------------------------------------------------------------------------------------
G
V
S
E
L
L
I
--------
S
T
A
V
Q
G
I
L
F
A
L
-
L
-
G
A
Q
P
L
L
V
V
G
F
S
G
P
L
L
V
F
E
E
A
-
F
F
S
F
C
E
T
N
GL
E
Y
I
---
V
G
R
V
W
I
G
F
-
W
L
I
L
L
V
V
L
V
---
V
A
-----
F
E
G
S
F
--
L
V
R
F
I
S
R
Y
T
--------
Q
E
I
F
S
F
L
I
S
L
I
--
F
I
Y
E
T
F
S
K
L
--
I
K
I
F
---
Q
D
H
P
L
Q
K
T
YL
P
N
T
A
L
L
S
L
V
L
M
A
G
T
F
F
F
A
M
M
L
R
K
F
K
N
S
SYFPG
K
L
R
R
V
I
G
D
F
G
-
V
P
I
S
I
L
I
M
V
L
V
---
D
F
F
I
Q
D
T
Y
T
Q
K
L
S
VPDGFKV----
V
---
I
H
P
L
G
L
R
S
--
E
F
-
P
I
--
W
M
M
F
A
S
A
L
P
A
L
L
V
F
I
L
I
F
L
E
S
Q
I
T
T
L
I
V
S
------------
K
P
E
R
K
-
M
V
K
G
--
S
G
F
H
L
D
L
L
L
V
V
G
--
M
G
G
V
A
A
L
F
G
M
-------------------
P
W
L
S
A
T
-
T
V
R
S
V
----------
T
H
A
N
--
A
L
TVM--I
Q
E
V
K
E
Q
R
I
S
-------
G
L
L
V
A
V
L
V
----
G
L
S
I
L
--------
M
E
P
-
I
L
S
R
I
------
P
L
A
V
L
F
-
G
I
F
L
----
Y
-------------------------
M
G
---------
V
T
S
L
S
G
-------------------------------------------------------------------------------------
11
PsiBlast_PDB
33.69
24%
-89
- C7 -
4EY7
4
ACES_HUMAN
A:
[240-409]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
-------------------
P
-------
N
D
T
E
----------
L
V
A
C
L
R
T
----
R
P
-----
A
Q
V
L
V
-------
N
H
E
W
H
V
L
P
QESV
F
R
F
S
F
V
-----
P
V
V
D
G
D
F
L
S
D
T
------
P
E
A
L
I
N
-
A
G
D
F
HG
L
Q
V
--
L
-----
V
G
V
V
K
-----------
D
E
G
---------
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
-------
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
----
P
E
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
--------
9
PsiBlast_PDB
33.34
24%
-93
- C7 -
4EY5
5
ACES_HUMAN
A:
[240-409]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
-------------------
P
-------
N
D
T
E
----------
L
V
A
C
L
R
T
----
R
P
-----
A
Q
V
L
V
-------
N
H
E
W
H
V
L
P
QESV
F
R
F
S
F
V
-----
P
V
V
D
G
D
F
L
S
D
T
------
P
E
A
L
I
N
-
A
G
D
F
HG
L
Q
V
--
L
-----
V
G
V
V
K
-----------
D
E
G
---------
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
-------
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
----
P
E
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
--------
13
PsiBlast_PDB
33.13
24%
-90
- C7 -
4M0E
4
ACES_HUMAN
A:
[240-408]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
-------------------
P
P
------
N
D
T
E
----------
L
V
A
C
L
R
T
----
R
P
-----
A
Q
V
L
V
-------
N
H
E
W
H
V
L
P
QESV
F
R
F
S
F
V
-----
P
V
V
D
G
D
F
L
S
D
T
------
P
E
A
L
I
N
-
A
G
D
F
HG
L
Q
V
--
L
-----
V
G
V
V
K
-----------
D
E
G
---------
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
-------
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
----
P
E
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
--------
14
PsiBlast_PDB
33.07
24%
-96
- C7 -
4M0F
4
ACES_HUMAN
A:
[240-409]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
-------------------
P
-------
N
D
T
E
----------
L
V
A
C
L
R
T
----
R
P
-----
A
Q
V
L
V
-------
N
H
E
W
H
V
L
P
QESV
F
R
F
S
F
V
-----
P
V
V
D
G
D
F
L
S
D
T
------
P
E
A
L
I
N
-
A
G
D
F
HG
L
Q
V
--
L
-----
V
G
V
V
K
-----------
D
E
G
---------
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
-------
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
----
P
E
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
--------
8
PsiBlast_PDB
32.98
24%
-91
- C7 -
4EY4
2
ACES_HUMAN
A:
[240-409]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
-------------------
P
-------
N
D
T
E
----------
L
V
A
C
L
R
T
----
R
P
-----
A
Q
V
L
V
-------
N
H
E
W
H
V
L
P
QESV
F
R
F
S
F
V
-----
P
V
V
D
G
D
F
L
S
D
T
------
P
E
A
L
I
N
-
A
G
D
F
H
G
L
Q
V
--
L
-----
V
G
V
V
K
-----------
D
E
G
---------
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
-------
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
----
P
E
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
--------
34
Fugue
32.76
13%
-152
- C3 -
4LL8
-
MYO4_YEAST
A:
[1016-1468]
--------------------------------------ERA
A
A
Q
S
S
L
I
Q
S
H
M
Q
S
L
A
-
A
N
K
P
S
R
-
L
-
S
D
E
V
K
S
M
K
Q
E
L
A
-
F
I
----
E
N
------
V
I
A
Q
A
------
N
K
P
K
L
V
N
V
I
--------
R
R
E
S
G
N
P
D
L
L
E
L
L
-
M
D
L
N
S
Y
T
L
E
V
T
E
G
Y
L
K
K
----
V
N
V
T
E
V
N
---
G
D
N
VL
G
P
I
H
V
I
T
T
V
-
V
S
S
L
V
R
N
G
L
---
L
I
Q
S
S
K
-
F
I
S
K
V
--
L
L
T
V
E
S
I
V
M
S
LPKDET
M
L
G
G
I
F
W
L
S
N
L
S
R
L
P
A
F
A
A
N
Q
K
T
--
L
Y
E
A
---
N
G
G
D
E
-----
K
D
K
L
T
L
I
Y
L
N
D
L
E
N
E
T
L
K
V
F
D
K
I
Y
S
T
W
-----
L
V
K
F
M
----
K
-
H
A
S
A
H
I
E
I
F
D
M
---
V
L
N
E
K
L
--
F
K
N
S
G
-------
D
E
K
F
A
--
K
L
F
T
F
L
N
E
F
D
A
V
L
-
S
---
K
--
F
Q
V
V
D
S
M
H
T
K
I
F
N
D
T
L
K
Y
L
N
V
M
L
F
N
D
------------------
L
I
T
K
--
S
P
A
L
N
W
K
Y
G
Y
E
V
--
D
R
N
I
E
R
L
V
S
W
-------------------
F
E
P
R
I
E
-
D
V
R
P
N
----------
L
I
Q
I
--
I
----
Q
A
-----
V
K
I
L
Q
L
K-----
I
S
N
L
N
E
F
K
----
L
L
F
D
F
W
YALN
P
A
Q
I
Q
A
-
I
L
L
K
Y
------
K
P
A
N
K
G
-
E
A
G
------------------
V
-----------
P
N
E
---------
I
L
N
Y
L
A
N
V
I
K
R
E
N
L
S
L
P
-----------
G
K
M
E
I
M
L
S
A
Q
----
F
D
S
A
K
N
H
L
R
Y
D
T
S
A
I
T
Q
----
N
S
N
----
T
E
G
L
A
T
V
S
K
I
I
K
L
--------