@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15710: (2016-06-24 )
MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPRKIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQAMLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGDIDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKIPAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAFEPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVNRFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDEEHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKHRVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFVMCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQRVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPNVTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQLTKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGADTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISIDMNPYMMM
Atome Classification :
(20 SA)
-------------------------------------------------------------------.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220..-.....230.......240........250.......260.......270.......280.......290.......300.......310..---------------------.------------..------------..320.......330.....---..340-.----.----.-------..-....350.----......360.--......370-----.........---------380----------.--..--------......390...--....400.....--..410..--.-----.--.-----..420.......--430......----.----.---440.--.--.......450...-....460--........470.......480.......---490.......500.......510.......520.......530.......540.......550.......560......-.570...-..-..580.......590.......600.......610.......620.......630.......640.....-..650.......660-..--.--.....670.......680.......690.......700.......710.......720.......730.......740.--......750.......760.......770.......780.......790.......800...-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------M
N
F
A
E
V
I
V
D
VSTKNIDRPFDYKI
P
D
H
L
K
G
M
I
KTG
M
R
V
I
VPFG
P
R
K
I
Q
G
F
V
T
A
V
K
E
A
SDLSGK
S
V
K
E
V
E
D
L
L
D
L
T
P
V
L
T
E
E
L
M
I
L
S
S
W
LSDK
T
L
S
F
K
I
T
A
L
Q
A
M
L
P
A
A
L
K
A
K
Y
E
K
ELKIAHGADL
P
P
Q
V
E
R
L
F
S
E
T
K
T
L
L
YSDIP
D
H
E
T
L
K
L
I
Q
R
H
V
QKGD
I
D
V
T
Y
K
V
A
Q
KT
N
K
K
M
V
R
H
I
QANA
S
K
E
E
L
A
K
Q
A
EG
L
S
R
Q
A
A
K
Q
Q
A
I
L
H
F
L
ISEPEGVKI
P
A
A
E
L
C
-KKTDTS
S
A
T
I
K
T
L
I
Q
K
-
G
L
L
K
E
S
Y
E
E
V
Y
RDPY
Q
D
K
MFKKTEPLPLT
D
E
Q
R
A
A
F
E
P
I
R
E
TLDSDE
H
K
V
F
L
L
HGVTGSG
K
T
E
I
Y
L
Q
S
I
E
K
V
L
A---------------------K------------GK------------
E
A
I
V
L
VPEISL
T
P
Q
M
V
N
R
F
K
---
G
RF---G----
S
----
Q
-------
V
A
-
V
M
HSGLST----G
E
K
Y
D
E
W
R
K
I
--
H
R
K
E
V
R
L
-------
V
V
GA
R
S
A
I
F
---------
A
------------
P
--
F
E
--------NL
G
M
I
I
I
DEEHE--SSY
K
Q
E
E
M
P
R
Y
H
--
A
K
E
V
A
I
K--R-----A--E-----HHSC
P
V
V
LGSAT--
P
T
-
L
E
S
Y
A
R
----
A
----
Q
---
K
--
G
--
V
--
Y
E
L
L
S
L
K
H
R
VNHR-VMP
E
V
-
S
--
L
V
D
M
R
E
E
L
RNGNRS
M
F
S
V
E
L
M
E
K
L
E
E
T
I
---AKG
E
Q
A
V
L
F
L
NKRGYS
S
F
V
M
CRDCGYVPQCPHCDI
S
M
T
Y
H
RYGQ
R
L
K
C
H
YCGHEEPVPHT
C
P
E
C
A
S
E
H
I
R
FFGT
G
T
Q
R
V
-
E
E
E
L
T
K
V-LP-S
A
R
V
I
R
M
DVDTTSRK
G
A
H
E
K
L
L
S
A
FGEGK
A
D
I
L
L
G
T
Q
M
I
AKGLDFPN
V
T
L
V
G
V
LSAD
T
T
L
HIPDF
R
S
A
E
K
-
T
F
Q
L
L
T
Q
VSGRAGR--HE--K--P
G
H
V
I
I
Q
T
YTPS
H
Y
S
I
Q
L
T
KTHD
Y
E
T
F
Y
Q
H
E
M
A
H
R
R
EQSYP
P
Y
Y
Y
L
A
L
V
T
V
S
H
E
E
V
A
K
A
A
V
T
A
E
K
I
A
H
F
L
K
ANCGAD
T
K
--ILGPSAS
P
I
A
R
I
K
D
R
Y
R
Y
Q
C
V
I
K
YKQ
E
T
Q
L
S
A
L
L
K
K
I
L
E
H
Y
K
R
E
I
EQK
H
V
M
I
S
IDMNPYMMM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
77.99
36%
-95
* C3 *
4NL4
3
?
H:
[18-747]
--------------------------------------------------------------------
S
V
A
H
V
A
L
P
V
P
---
L
P
R
T
F
D
Y
L
L
P
E
G
M
A
--
V
K
A
G
C
R
V
R
V
P
F
G
K
Q
E
R
I
G
I
V
A
A
V
S
E
R
S
E
L
P
L
D
E
L
K
P
V
A
E
A
L
D
D
E
P
V
F
S
-------------------
T
T
V
W
R
L
L
M
W
A
A
E
Y
Y
H
H
------------
P
I
G
D
V
L
F
H
A
L
P
V
M
L
R
Q
G
K
P
A
S
A
T
P
L
W
Y
W
F
A
T
E
Q
G
Q
V
----------------------------
V
D
L
N
G
L
K
R
S
R
K
Q
Q
Q
A
L
A
A
L
R
Q
G
K
I
W
R
H
Q
V
G
E
L
E
F
-------
N
E
A
A
L
Q
A
L
R
G
K
-
G
L
A
E
L
A
C
E
A
---
T
D
W
R
S
A
Y
S
V
A
G
E
R
L
R
L
N
T
E
Q
A
T
A
V
G
A
I
H
S
A
--
A
D
R
F
S
A
W
L
L
A
G
I
T
G
S
G
K
T
E
V
Y
L
S
V
L
E
N
V
L
A
---------------------
Q
------------
G
R
------------
Q
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
---
Q
R
F
---
N
----
A
----
P
-------
V
E
-
V
L
H
S
G
L
N
D
----
S
E
R
L
S
A
W
L
K
A
--
K
N
G
E
A
A
I
-------
V
I
G
T
R
S
S
L
F
---------
T
------------
P
--
F
K
--------
D
L
G
V
I
V
I
D
E
E
H
D
--
S
S
Y
K
Q
Q
E
G
W
R
Y
H
--
A
R
D
L
A
V
W
--
R
-----
A
--
H
-----
S
E
Q
I
P
I
I
L
G
S
A
T
--
P
A
-
L
E
T
L
H
N
----
V
----
R
---
Q
--
G
--
K
--
Y
R
Q
L
T
L
S
K
P
A
Q
Q
H
-
V
L
D
---------
L
K
G
Q
P
L
Q
A
G
---
L
S
P
A
L
I
S
R
M
R
Q
H
L
---
Q
A
D
N
Q
V
I
L
F
L
N
R
R
G
F
A
P
A
L
L
C
H
D
C
G
W
I
A
E
C
P
R
C
D
S
Y
Y
T
L
H
Q
A
Q
H
H
L
R
C
H
H
C
D
S
Q
R
P
I
P
R
Q
C
P
S
C
G
S
T
H
L
V
P
V
G
I
G
T
E
Q
L
-
E
Q
A
L
A
P
L
-
F
P
-
E
V
P
I
S
R
I
D
-----------
R
H
L
A
A
V
H
R
G
G
A
R
I
L
I
G
T
Q
M
L
A
K
G
H
H
F
P
D
V
T
L
V
S
L
L
D
V
D
G
A
L
F
S
A
D
F
R
S
A
E
R
-
F
A
Q
L
Y
T
Q
V
S
G
R
A
G
R
--
A
G
--
K
--
Q
G
E
V
I
L
Q
T
H
H
P
E
H
P
L
L
Q
T
L
L
Y
K
G
Y
D
A
F
A
E
Q
A
L
A
E
R
Q
T
M
Q
L
P
P
W
T
S
H
V
L
I
R
A
E
D
H
N
N
Q
Q
A
P
L
F
L
Q
Q
L
R
N
L
L
Q
A
S
P
L
A
D
E
K
LW
V
L
G
P
V
P
A
L
--------
R
W
Q
I
L
L
Q
H
P
S
R
V
R
L
Q
H
I
V
S
G
T
L
A
L
I
N
T
L
P
E
A
W
----
V
L
D
V
D
P
I
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
45.82
24%
-111
- C1 -
1GM5
2
?
A:
[364-703]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
P
F
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
---------------------
A
------------
G
F
------------
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
---
E
S
F
---
S
KF
N
-
I
----
H
-------
V
A
-
L
L
I
G
A
T
T
P
----
S
E
K
E
K
I
K
S
G
L
--
R
N
G
Q
I
D
V
-------
V
I
G
T
H
A
L
I
Q
E
D
-------
V
------------
H
--
F
K
--------
N
L
G
L
V
I
I
D
E
Q
H
R
--
F
--------------
E
A
L
M
N
---
K
-----
G
---------
K
M
V
D
T
L
V
M
S
A
T
--
P
I
-
P
R
S
M
A
L
----
A
----
F
---
Y
--
G
--
D
--
L
D
V
T
V
I
D
E
M
P
P
---
G
R
K
E
V
-
Q
--
T
M
L
V
P
M
--------
D
R
V
N
E
V
Y
E
F
V
R
Q
E
V
---
M
R
G
G
Q
A
F
I
V
Y
P
L
I
------------------------------------------------------------
K
S
A
V
E
M
-
Y
E
Y
L
S
K
E
V
F
----
K
L
G
L
M
H
G
R
L
S
--
Q
E
E
K
D
R
V
M
L
E
F
A
E
G
R
Y
D
I
L
V
S
T
T
V
I
E
V
G
I
D
V
P
R
A
N
V
M
V
I
E
N
P
E
-----
R
F
-------
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
--
G
G
--
Q
--
E
A
Y
C
F
L
V
V
G
D
V
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
41.63
16%
-119
- C1 -
5ANR
-
DDX6_HUMAN
B:
[99-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
-
G
W
E
K
-----------------------
P
S
P
I
Q
E
E
S
I
P
I
A
L
------
S
G
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
D
LKK------------------
D
------------
N
I
------------
Q
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
---
Q
V
S
---
K
HMGG
A
----
K
-------
V
M
-
A
T
T
G
G
T
N
L
----
R
D
D
---
I
M
R
L
---
D
D
T
V
H
V
-------
V
I
A
T
P
G
R
I
L
D
L
I
K
K
GV--
A
------------
K
--
V
D
--------
H
V
Q
M
I
V
L
D
E
A
D
K
--
L
L
S
Q
---
D
F
V
Q
I
--
M
E
D
I
I
L
T
--
L
-----
P
--
K
-------
N
R
Q
I
L
L
Y
S
A
T
--
F
P
-
L
S
V
Q
K
F
----
M
----
N
---
S
--
H
--
L
QK
P
Y
E
I
N
L
M
E
E
L
T
---
L
K
G
V
T
-
Q
--
Y
Y
A
Y
V
T
E
R
------
Q
-
K
V
H
C
L
N
T
L
F
S
R
----
L
Q
I
N
Q
S
I
I
F
C
N
S
------------------------------------------------------------
S
Q
R
V
E
L
L
-
A
K
K
I
S
Q
L
----
G
Y
S
C
F
Y
I
H
A
K
M
R
--
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
----
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
-------
L
A
E
T
Y
L
H
R
I
G
R
S
G
----------
L
G
L
A
I
N
L
I
T
Y
D
D
R
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
41.46
22%
-119
- C1 -
2EYQ
1
MFD_ECOLI
A:
[589-776]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---------------------
N
------------
H
K
------------
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
---
D
R
F
---
A
----
N
WP
V
-
R
-------
I
E
-
M
I
S
R
F
R
S
A
----
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
I
-------
L
I
G
T
H
K
L
L
Q
---------
S
------------
D
VK
F
K
--------
D
L
G
L
L
I
V
D
E
E
H
R
--
F
G
V
R
-------
H
--
K
E
R
I
K
A
M
--
R
-----
A
----------
N
V
D
I
L
T
L
T
A
T
--
P
I
-
P
R
T
L
N
M
----
A
----
M
---
S
--
G
--
M
--
R
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
40.93
20%
-62
- C1 -
5DCA
-
BRR2_YEAST (first)
A:
[113-2163]
D
P
S
N
V
E
T
Y
E
Q
I
L
Q
W
V
T
E
V
LGNDIP
H
D
L
I
I
G
T
A
D
I
F
I
R
Q
LKENEENEDGNIEE
R
K
E
K
I
QH
E
L
G
I
N
I
D
S
L
K
F
N
E
L
V
K
L
M
--
K
N
I
N
K
R
A
L
P
N
I
E
N
D
I
I
K
L
S
D
S
K
T
S
N
I
E
S
V
P
I
Y
S
I
D
E
F
F
L
Q
R
K
L
R
S
E
L
G
Y
K
D
---
T
S
V
I
Q
D
L
S
E
K
I
L
N
D
I
---------
E
T
L
E
H
N
P
V
A
L
E
Q
K
L
V
D
L
L
K
F
E
-----
N
I
S
L
A
E
F
I
L
K
N
R
S
T
I
F
W
G
I
R
L
---
A
K
S
T
E
N
E
I
P
N
L
I
E
K
M
V
A
K
G
L
N
D
L
V
E
Q
Y
K
F
R
E
N
P
A
I
P
P
V
I
D
L
E
K
I
K
F
D
E
S
S
K
L
M
T
V
T
K
V
S
L
P
E
G
S
F
K
R
V
K
-
P
Q
Y
D
E
I
H
I
P
A
P
S
K
--
P
V
I
D
Y
E
L
K
E
I
T
S
L
----------------
P
D
W
C
Q
E
A
F
P
S
S
E
T
T
S
L
N
P
I
Q
S
K
V
F
H
A
A
F
E
G
D
S
N
-----
M
L
I
C
A
P
T
G
S
G
K
T
N
I
A
L
L
T
V
L
K
A
L
S
---------------------
H
------------
H
Y
NPKTKKLNLSA
F
K
I
V
Y
I
A
P
L
K
A
L
V
Q
E
Q
V
R
E
F
Q
---
R
R
L
AFL
G
----
I
----
K
-------
V
A
-
E
L
-----
T
----
G
D
S
R
L
S
R
K
Q
I
--
D
E
T
Q
V
L
V
S
T
P
E
K
W
D
I
T
T
R
N
S
N
N
L
---------
A
------------
I
--
V
E
--------
L
V
R
L
L
I
I
D
E
I
H
L
--
L
H
D
D
R
G
P
V
L
E
S
I
--
V
A
R
T
F
W
A
--
S
-----
K
--
Y
-----
G
Q
E
Y
P
R
I
I
G
L
S
A
TL
P
N
-
Y
E
D
V
G
R
F
L
RV
P
----
K
---
E
--
G
--
L
--
F
Y
F
D
S
S
F
R
P
C
P
-----
L
S
Q
-
Q
--
F
C
G
I
K
E
R
N
S
L
K
K
L
K
A
M
N
D
A
C
Y
E
K
V
L
E
S
I
---
N
E
G
N
Q
I
I
V
F
V
H
S
-----------------------
R
K
E
T
S
R
T
A
T
W
L
K
N
K
F
A
--
E
E
N
I
T
H
K
L
T
K
N
D
A
G
S
K
Q
I
L
K
T
E
A
A
N
V
L
D
P
S
L
R
K
L
-
I
E
-
S
G
I
G
T
H
H
A
G
L
T
R
S
D
R
S
L
S
E
D
L
F
A
---
D
G
L
L
Q
V
L
V
C
T
A
T
L
A
W
G
V
N
L
P
A
H
T
V
I
I
K
---
G
T
D
V
Y
S
P
E
K
G
S
W
E
Q
L
S
P
Q
D
V
L
Q
M
L
G
R
A
G
R
PR
Y
D
--
T
--
F
G
E
G
I
I
I
T
D
---------------
Q
S
N
V
Q
Y
Y
L
S
V
L
N
Q
Q
L
P
--------
I
E
S
Q
F
V
S
K
L
V
D
N
L
N
A
E
V
V
A
G
N
I
K
--
C
R
N
D
A
V
--
N
W
L
A
Y
T
Y
L
Y
V
R
M
L
A
S
P
M
L
Y
K
V
P
D
I
S
S
D
G
Q
L
K
K
F
R
E
S
L
V
H
S
A
L
C
I
L
K
E
Q
E
L
V
L
Y
D
A
E
N
D
V
I
E
A
T
D
L
G
N
I
A
S
S
F
YIN
H
A
S
M
D
V
Y
N
R
E
LDEHTT
Q
I
D
L
F
R
I
F
S
M
SEEFKY
V
S
V
R
YEE
K
R
E
L
K
Q
L
L
E
K
APIPIREDIDD
P
L
A
K
V
N
V
L
L
Q
S
Y
F
S
QLKFEG
F
A
L
N
S
D
I
V
F
I
H
Q
N
A
G
R
L
L
R
A
M
F
E
I
C
L
K
R
GW
G
H
P
T
R
M
L
L
N
L
C
K
S
A
T
T
KMWPTNCPLRQFKTCP
V
E
V
I
K
R
L
E
A
S
TVPW
G
D
Y
L
Q
LET
P
A
E
V
G
R
A
I
RSEKYG
K
Q
V
Y
D
L
L
K
R
F
P
K
M
S
V
T
C
N
A
Q
P
ITRS
V
M
R
F
N
I
E
I
I
A
D
W
I
W
D
MNVHGS
L
E
P
F
L
L
M
L
E
D
TDGDSIL
Y
Y
D
V
L
F
I
T
PDIVG
H
E
F
T
L
S
F
T
Y
E
L
K
Q
H
N
Q
N
NLPP
N
F
F
L
T
L
I
S
ENWWHS
E
F
E
I
P
VSFNG
F
K
L
P
K
KFPPPTPLLEN
I
S
I
S
TSELGN
D
D
F
S
E
V
FEFKTFN
K
I
Q
S
Q
V
FESLYNSN
D
S
V
F
V
G
S
G
KGTG
K
T
A
M
A
E
L
A
L
L
N
H
W
R
Q
NK
G
R
A
V
Y
I
N
PS
G
E
K
I
D
F
L
L
S
D
W
N
K
RFSHLA
G
G
K
I
I
N
KLGND
P
S
L
N
L
K
L
L
A
K
S
H
V
L
L
A
T
P
V
Q
F
E
L
L
S
R
RWRQR
K
N
I
Q
S
LE
L
M
I
Y
D
DAHEISQG
V
Y
G
A
V
Y
E
T
L
I
S
R
M
I
F
I
A
T
Q
L
EKK
I
R
F
V
C
L
S
N
CLANA
R
D
F
G
E
W
A
GMTKSN
I
Y
N
F
S
PSERI
E
P
L
E
I
N
I
Q
S
F
K
DVEHISFN
F
S
M
L
Q
M
A
F
E
A
S
A
A
A
A
G
N
R
N
S
S
S
V
F
L
PS
R
K
D
C
M
E
V
A
S
A
F
M
K
F
S
K
AIEWDMLNVEEEQI
V
P
Y
I
E
K
LTD
G
H
L
R
A
P
L
K
H
G
V
G
I
L
Y
KGMA
S
N
D
E
R
I
V
K
R
L
Y
E
Y
GAVS
V
L
L
I
S
KDCSAFACKTD
E
V
I
I
LGT
N
L
Y
D
GAEH
K
Y
M
P
Y
T
I
N
E
L
L
E
M
V
G
L
A
S
G
N
DSM
A
G
K
V
L
I
L
T
S
H
N
M
K
A
Y
Y
K
K
F
L
IEPLPTESYLQYI
I
H
D
T
L
N
N
E
I
A
N
SIIQS
K
Q
D
C
V
D
W
F
T
Y
S
Y
F
Y
R
R
I
H
V
NPSYYGVRDTS
P
H
G
I
S
V
F
L
S
N
L
V
E
T
C
L
N
D
L
V
E
S
SF
I
E
I
D
D
TEAET
E
I
I
S
T
L
S
N
G
L
I
A
S
H
Y
GVS
F
F
T
I
Q
S
F
V
S
S
LSNTST
L
K
N
M
L
Y
V
L
S
T
AVEFES
V
P
L
R
KG
D
R
A
L
L
V
K
L
S
K
R
LPLRFPEHTSSGS
V
S
F
K
V
F
L
L
L
Q
A
Y
F
S
RLELP
V
D
F
Q
N
D
L
K
D
I
L
E
K
V
V
P
L
I
N
V
V
V
D
I
L
S
A
N
GYLN
A
T
T
A
M
D
L
A
Q
M
L
I
Q
GVWDVDNPLRQIPHFN
N
K
I
L
E
K
C
K
E
I
NVET
V
Y
D
I
M
A
LE
D
E
E
R
D
E
I
LTLT
D
S
Q
L
A
Q
V
A
A
F
V
N
N
Y
P
N
V
E
L
T
Y
SLNNSDSLISG
V
K
Q
K
I
T
I
Q
L
T
R
DVEPENLQVTSEKYP
F
D
K
L
E
S
W
W
L
V
L
G
E
VSKKELY
A
I
K
K
V
T
LNKE
T
Q
Q
Y
E
L
E
F
D
T
P
T
S
G
K
H
N
L
T
I
W
CVCDSYLDA
D
K
E
L
S
F
E
I
N
V
K
56
HHSearch
40.65
17%
-96
- C1 -
4F92
-
U520_HUMAN
B:
[79-540]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
N
R
I
Q
S
K
L
Y
R
A
A
L
-----
E
T
D
E
N
L
L
L
C
A
P
T
G
A
G
K
T
N
V
A
L
M
C
M
L
R
E
I
G
KHINMDGTINV----------
D
------------
D
F
------------
K
I
I
Y
I
A
P
M
R
S
L
V
Q
E
M
V
G
S
F
G
---
K
R
L
---
A
TYG-
I
----
T
-------
V
A
-
E
L
T
G
D
H
Q
L
----
C
K
E
--
E
-------
I
S
A
T
Q
I
-------
I
V
C
T
P
E
K
W
D
IITRKGGER
T
------------
Y
--
T
Q
--------
L
V
R
L
I
I
L
D
E
I
H
L
--
L
H
D
--
D
R
G
P
V
L
E
AL
V
A
R
A
I
R
N
I-
E
-----
M
--
T
-----
Q
E
D
V
R
L
I
G
L
S
A
T
--
L
P
N
Y
E
D
V
A
T
----
F
----
L
---
R
--
V
--
D
PA
K
G
L
F
Y
F
D
N
S
F
R
P
--
V
P
L
E
Q
-
T
--
Y
V
G
I
T
E
K
K
A
I
K
R
F
Q
I
M
N
E
I
V
Y
E
K
I
M
E
H
----
A
G
K
N
Q
V
L
V
F
V
H
S
R
K
E
T
G
K
T
A
R
A
I
R
D
M
C
L
E
K
D
T
L
G
L
F
L
R
E
-----------
G
S
A
S
T
-----------
E
V
L
R
T
---
E
A
E
Q
C
K
N
L
E
L
K
D
L
-
L
--
P
Y
G
F
A
I
H
H
A
G
M
T
--
R
V
D
R
T
L
V
E
D
L
F
A
D
K
H
I
Q
V
L
V
S
T
A
T
L
A
W
G
V
N
L
P
A
H
T
V
I
I
K
--
G
T
Q
V
Y
S
P
E
K
G
R
W
T
E
L
-
G
A
L
D
I
L
Q
M
L
G
R
A
G
R
--
P
Q
--
Y
DT
K
G
E
G
I
L
I
T
S
H
G
E
L
Q
Y
--------
Y
L
S
L
L
N
Q
--------
Q
L
P
I
E
S
Q
M
V
S
K
L
P
D
M
L
N
A
E
I
V
L
G
N
V
Q
N
A
--------
K
D
A
V
N
--
W
L
G
Y
A
Y
L
Y
I
R
M
L
R
S
P
T
L
Y
G
I
S
H
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
40.29
29%
-126
- C1 -
1GM5
2
?
A:
[361-552]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
K
S
L
P
F
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
---------------------
A
------------
G
F
------------
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
ESF
S
K
F
---
N
----
I
----
H
-------
V
A
-
L
L
I
G
A
T
T
P
----
S
E
K
E
K
I
K
S
G
L
--
R
N
G
Q
I
D
V
-------
V
I
G
T
H
A
L
I
Q
---------
E
------------
D
V
H
F
K
--------
N
L
G
L
V
I
I
D
E
Q
H
R
--
F
-----
E
A
L
M
N
K
--
G
K
M
V
------------------------
D
T
L
V
M
S
A
T
--
P
I
-
P
R
S
M
A
L
----
A
----
F
---
Y
--
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
40.27
18%
-102
- C1 -
3SQW
3
MS116_YEAST
A:
[20-406]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
L
-
E
E
G
V
L
D
K
E
I
H
K
A
I
T
R
M
-
E
F
P
G
-----------------------
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
----
S
E
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
---------------------
N
T
KFDSQY-----
M
V
------------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
---
K
I
H
---
D
----
M
----
N
YGLKKY
A
C
V
-
S
L
V
G
G
T
D
F
----
R
---
A
A
M
N
K
M
--
N
K
L
R
P
N
I
-------
V
I
A
T
P
G
R
L
I
---------
D
V
L
E
K
YSNK----
F
--
F
R
--------
F
V
D
Y
K
V
L
D
E
A
D
R
--
L
L
E
I
---
G
F
R
D
D
--
L
E
T
I
S
G
I
--
L
-----
N
--
E
K
NSKS
A
D
N
I
K
T
L
L
F
S
A
T
--
L
D
-
D
K
V
Q
K
L
----
A
----
N
---
N
IM
N
--
K
--
K
E
C
L
F
L
D
T
V
D
K
---
N
E
P
E
A
H
E
--
R
I
D
Q
S
V
V
I
S
E
-
K
F
A
N
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
------------------------------------------------------------
F
T
S
F
L
-
C
S
I
L
K
N
E
-
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
--
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
-------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
--
S
G
--
K
--
E
G
S
S
V
L
F
I
C
K
D
E
L
P
F
V
R
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
40.10
17%
-95
- C1 -
3PEY
10
DBP5_YEAST
A:
[9-361]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
-
K
F
Q
K
-----------------------
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
----
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
PED------------------
A
------------
S
P
------------
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
---
E
M
G
---
K
----
F
----
T
K
I
T
----
S
Q
-
L
I
V
P
D
------------
S
F
E
K
N
--
K
Q
I
N
A
Q
V
-------
I
V
G
T
P
G
T
V
L
D
L
M
R
R
KL--
M
------------
Q
--
L
Q
--------
K
I
K
I
F
V
L
D
E
A
D
N
--
M
L
D
Q
Q
--
G
L
G
D
Q
--
C
I
R
V
K
R
F
--
L
-----
P
--
K
-------
D
T
Q
L
V
L
F
S
A
T
--
F
A
-
D
A
V
R
Q
Y
----
A
----
K
---
K
I
V
P
--
N
--
A
N
T
L
E
L
Q
T
N
E
V
---
N
V
D
A
I
-
K
Q
L
Y
M
D
C
K
N
E
A
------
D
K
F
D
V
L
T
-
E
L
Y
G
-
L
---
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
------------------------------------------------------------
N
V
L
-
Y
G
K
L
K
S
E
----
G
H
E
V
S
I
L
H
G
D
L
Q
--
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
L
A
N
G
Q
A
-
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
--
F
G
--
R
--
K
G
V
A
I
S
F
V
H
D
K
N
S
F
N
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
40.08
19%
-94
- C1 -
4D25
4
?
A:
[54-409]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
-
G
Y
R
K
-----------------------
P
T
P
I
Q
K
N
A
I
P
I
I
M
------
S
G
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
---------------------
Q
D
PKD
L
I
S
E
NG
C
A
Q
P
------------
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
---
K
F
S
---
Y
----
G
SV
L
-
K
-------
V
A
-
V
A
Y
G
G
T
A
V
----
R
H
Q
G
D
N
I
------
A
R
G
C
H
I
-------
L
V
A
T
P
G
R
L
H
D
F
V
E
R
NR--
V
------------
S
--
F
G
--------
S
V
R
F
V
V
L
D
Q
A
D
C
--
M
L
D
M
---
G
F
M
P
S
--
I
E
K
M
M
L
H
PT
M
-----
V
--
E
-----
T
T
K
R
Q
T
L
M
F
S
A
T
--
F
P
-
E
D
I
Q
H
L
----
A
----
G
---
R
FL
N
--
N
--
Y
L
F
V
A
V
G
I
V
G
G
A
S
-
T
D
V
E
Q
-
I
--
F
I
E
V
T
K
Y
E
-------
K
R
N
S
L
K
Q
L
I
E
E
-----
N
D
G
K
R
I
L
V
F
V
E
T
K
R
------------------------------------------------------------
N
A
D
F
I
-
A
A
M
L
S
E
Q
----
Q
L
L
T
S
S
I
H
G
D
R
M
--
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
-------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
--
V
G
--
N
--
R
G
K
A
V
S
F
Y
D
S
D
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
39.99
18%
-100
* C1 *
3I5X
3
MS116_YEAST
A:
[76-456]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
V
L
D
K
E
I
H
K
A
I
T
R
M
-
E
F
P
G
-----------------------
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
----
S
E
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
---------------------
N
T
KFDSQY-----
M
V
------------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
---
K
I
H
---
D
----
M
NYGL
K
-------
K
Y
-
A
C
V
S
L
V
G
G
----
T
D
F
R
A
A
M
N
K
M
--
N
K
L
R
P
N
I
-------
V
I
A
T
P
G
R
L
I
---------
D
V
L
E
K
YSNK----
F
--
F
R
--------
F
V
D
Y
K
V
L
D
E
A
D
R
--
L
L
E
---
I
G
F
R
D
D
--
L
E
T
I
S
G
I
--
L
-----
N
--
E
K
NSKS
A
D
N
I
K
T
L
L
F
S
A
T
--
L
D
-
D
K
V
Q
K
L
----
A
----
N
---
N
IM
N
--
K
--
K
E
C
L
F
L
D
T
V
D
K
---
N
E
P
E
A
H
E
--
R
I
D
Q
S
V
V
I
S
E
-
K
F
A
N
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
------------------------------------------------------------
F
T
S
F
L
-
C
S
I
L
K
N
E
-
F
K
K
D
L
P
I
L
E
F
H
G
K
I
T
--
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
-------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
--
S
G
--
K
--
E
G
S
S
V
L
F
I
C
K
D
E
L
P
F
V
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
39.81
18%
-93
- C1 -
5DCA
-
BRR2_YEAST (first)
A:
[497-970]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
L
N
P
I
Q
S
K
V
F
H
A
A
F
-----
E
G
D
S
N
M
L
I
C
A
P
T
G
S
G
K
T
N
I
A
L
L
T
V
L
K
A
L
S
---------------------
H
H
YNPKTKKLNLS
A
F
------------
K
I
V
Y
I
A
P
L
K
A
L
V
Q
E
Q
V
R
E
F
Q
---
R
R
L
---
A
FLG-
I
----
K
-------
V
A
-
E
L
T
G
D
S
R
L
----
S
R
K
-----
Q
----
I
D
E
T
Q
V
-------
L
V
S
T
P
E
K
W
D
I
T
T
R
NSNNL
A
------------
I
--
V
E
--------
L
V
R
L
L
I
I
D
E
I
H
L
--
L
H
D
--
D
R
G
P
V
L
E
----
S
I
V
A
R
--
T
F
W
A
S
K
Y
--
G
-----
Q
E
Y
P
R
I
I
G
L
S
A
T
--
L
P
N
Y
E
D
V
G
R
----
F
----
L
---
R
V-
P
--
K
--
E
G
L
F
Y
F
D
S
S
F
R
P
--
C
P
L
S
Q
-
Q
--
F
C
G
I
K
E
R
N
S
L
K
K
L
K
A
M
N
D
A
C
Y
E
K
V
L
E
S
I
---
N
E
G
N
Q
I
I
V
F
V
H
S
R
K
E
T
S
R
T
A
T
W
-----
L
K
N
K
F
A
E
E
N
-----
I
T
H
K
L
T
K
N
D
A
G
S
K
Q
I
L
K
T
--------------
E
A
A
N
V
L
-
D
P
S
L
R
K
L
-
I
--
E
S
G
I
G
T
H
H
A
G
L
T
--
R
S
D
R
S
L
S
E
D
L
F
A
D
G
L
L
Q
V
L
V
C
T
A
T
L
A
W
G
V
N
L
P
A
H
T
V
I
I
K
G
T
--
D
V
Y
S
P
E
K
G
S
W
E
Q
L
-
S
P
Q
D
V
L
Q
M
L
G
R
A
G
R
--
P
R
YD
T
--
F
G
E
G
I
I
I
T
D
Q
S
N
V
---
Q
Y
-----
Y
L
S
V
L
N
Q
--------
Q
L
P
I
E
S
Q
F
V
S
K
L
V
D
N
L
N
A
E
V
V
A
G
N
I
K
C
R
--------
N
D
A
V
N
--
W
L
A
Y
T
Y
L
Y
V
R
M
L
A
S
P
M
L
Y
K
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
39.64
17%
-105
- C1 -
2V1X
4
RECQ1_HUMAN
A:
[20-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
N
K
E
D
F
P
W
S
G
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
-----------------------
F
R
P
L
Q
L
E
T
I
N
V
T
M
------
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
------------------------
S
------------
D
G
------------
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
---
Q
L
----
G
----
I
----
S
-------
A
T
-
M
L
N
A
S
S
S
K
----
E
H
V
K
W
V
H
A
E
M
V
N
K
N
S
E
L
K
L
-------
I
Y
V
T
P
E
K
I
A
---------
K
S
K
M
F
M
S
R
L
E
K
A
Y
E
--
A
R
--------
R
F
T
R
I
A
V
D
E
V
H
C
--
C
S
Q
W
G
-
H
D
F
R
P
D
--
Y
K
A
L
G
I
L
--
K
-----
R
--
Q
-----
F
P
N
A
S
L
I
G
L
T
A
T
--
A
T
-
N
H
V
L
T
D
----
A
----
Q
---
K
I
L
C
--
I
--
E
K
C
F
T
F
T
A
S
F
----
N
R
P
N
L
-
Y
--
Y
E
V
R
Q
K
P
S
N
---
T
E
D
F
I
E
D
I
V
K
L
I
N
G
R
----
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
K
------------------------------------------------------------
D
S
E
Q
V
-
T
V
S
L
Q
N
L
----
G
I
H
A
G
A
Y
H
A
N
L
E
--
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
------
K
-------
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
--
D
D
--
M
--
K
A
D
C
I
L
Y
Y
G
F
G
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
39.63
21%
-120
- C1 -
3EIQ
-
IF4A1_HUMAN
A:
[35-396]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
M
N
L
S
E
S
L
L
R
G
I
Y
A
Y
-
G
F
E
K
-----------------------
P
S
A
I
Q
Q
R
A
I
L
P
C
I
------
K
G
Y
D
V
I
A
Q
A
Q
S
G
T
G
K
T
A
T
F
A
I
S
I
L
Q
Q
I
E
LDL------------------
K
------------
A
T
------------
Q
A
L
V
L
A
P
T
R
E
L
A
Q
Q
I
Q
K
V
V
M
---
A
L
G
---
D
----
Y
MG
A
-
S
-------
C
H
-
A
C
I
G
G
T
N
V
----
R
A
---
E
V
Q
K
L
--
Q
M
E
A
P
H
I
-------
I
V
G
T
P
G
R
V
F
D
M
L
N
R
RY--
L
------------
S
--
P
K
--------
Y
I
K
M
F
V
L
D
E
A
D
E
--
M
L
S
R
---
G
F
K
D
Q
--
I
Y
D
I
F
Q
K
--
L
-----
N
--
S
-------
N
T
Q
V
V
L
L
S
A
T
--
M
P
-
S
D
V
L
E
V
----
T
----
K
---
K
--
F
--
M
--
R
D
P
I
R
I
L
V
K
K
E
E
L
-
T
L
E
G
I
-
R
Q
F
Y
I
N
V
E
R
E
------
E
W
K
L
D
T
L
C
D
L
Y
E
T
-----
L
T
I
T
Q
A
V
I
F
I
N
T
R
R
K
------------------------------------------------------------
V
D
W
L
-
T
E
K
M
H
A
R
----
D
F
T
V
S
A
M
---
M
D
--
Q
K
E
R
D
V
I
M
R
E
F
R
S
G
---
V
L
I
T
T
D
L
L
A
--
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
------
P
T
-------
N
R
E
N
Y
I
H
R
I
G
R
G
-------------
V
A
I
N
M
V
T
E
E
D
K
R
T
L
R
-----
D
I
E
T
F
Y
N
T
S
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
39.05
16%
-122
- C1 -
1XTI
4
DX39B_HUMAN
A:
[11-357]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
-
G
F
E
H
-----------------------
P
S
E
V
Q
H
E
C
I
P
Q
A
I
------
L
G
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
E
---------------------
P
VTG---------
Q
V
------------
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
---
R
F
S
---
K
YMPN
V
----
K
-------
V
A
-
V
F
F
G
G
L
S
I
----
K
K
D
E
E
V
L
K
-----
K
N
C
P
H
I
-------
V
V
G
T
P
G
R
I
L
A
L
A
R
N
KS--
L
------------
N
--
L
K
--------
H
I
K
H
F
I
L
D
E
C
D
K
--
M
L
E
--
Q
L
D
M
R
R
D
--
V
Q
E
I
F
R
M
--
T
-----
P
--
H
-------
E
K
Q
V
M
M
F
S
A
T
--
L
S
-
K
E
I
R
P
V
----
C
----
R
---
K
--
F
MQ
D
--
P
M
E
I
F
V
D
D
E
T
K
L
T
L
H
G
L
Q
Q
-
Y
--
Y
V
K
L
K
D
N
E
-------
K
N
R
K
L
F
D
L
L
D
-
V
----
L
E
F
N
Q
V
V
I
F
V
K
S
V
Q
------------------------------------------------------------
R
C
I
A
L
-
A
Q
L
L
V
E
Q
----
N
F
P
A
I
A
I
H
R
G
M
P
--
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
------
E
-------
D
S
D
T
Y
L
H
R
V
A
R
A
G
R
--
F
G
--
T
--
K
G
L
A
I
T
F
V
S
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
38.90
19%
-98
- C1 -
4PXA
5
DDX3X_HUMAN
A:
[68-437]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
-
R
Y
T
R
-----------------------
P
T
P
V
Q
K
H
A
I
P
I
I
K
------
E
K
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
DGPG
E
A
L
R
A
M
K
E
NGRYGRR
K
Q
------------
Y
P
------------
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
---
K
F
S
---
Y
----
R
SR
V
-
R
-------
P
C
-
V
V
Y
G
G
A
D
I
----
G
Q
Q
---
I
R
D
L
---
E
R
G
C
H
L
-------
L
V
A
T
P
G
R
L
V
D
M
M
E
R
GK--
I
------------
G
--
L
D
--------
F
C
K
Y
L
V
L
D
E
A
D
R
--
M
L
V
M
---
G
F
E
P
Q
--
I
R
R
I
V
E
Q
--
D
-----
T
MP
P
-----
K
G
V
R
H
T
M
M
F
S
A
T
--
F
P
-
K
E
I
Q
M
L
----
A
----
R
---
D
F
L
D
--
E
--
Y
I
F
L
A
V
G
R
V
G
S
T
S
-
E
N
I
T
Q
-
K
--
V
V
W
V
E
E
S
D
-------
K
R
S
F
L
L
D
L
L
N
A
-
T
---
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
------------------------------------------------------------
A
D
S
L
-
E
D
F
L
Y
H
E
----
G
Y
A
C
T
S
I
H
G
D
R
S
--
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
-------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
V
G
--
N
--
L
G
L
A
T
S
F
F
N
E
R
N
I
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
38.76
43%
-237
- C1 -
4KBG
1
?
B:
[274-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
38.37
17%
-94
- C1 -
2DB3
3
VASA1_DROME
A:
[59-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
-
G
Y
K
I
-----------------------
P
T
P
I
Q
K
C
S
I
P
V
I
S
------
S
G
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
---------------------
E
DP
H
E
L
E
L
G----
R
P
------------
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
---
K
F
A
---
F
----
E
SY
L
-
K
-------
I
G
-
I
V
Y
G
G
T
S
F
----
R
H
Q
N
E
----
C
--
I
T
R
G
C
H
V
-------
V
I
A
T
P
G
R
L
L
D
F
V
D
R
TF--
I
------------
T
--
F
E
--------
D
T
R
F
V
V
L
D
E
A
D
R
--
M
L
D
---
M
G
F
S
E
D
--
M
R
R
I
M
T
H
--
V
-----
T
--
M
-----
R
P
E
H
Q
T
L
M
F
S
A
T
--
F
P
-
E
E
I
Q
R
M
----
A
----
G
---
E
F
L
K
--
N
--
Y
V
F
V
A
I
G
I
V
G
G
A
C
-
S
D
V
K
Q
-
T
--
I
Y
E
V
N
K
-------
Y
A
K
R
S
K
L
I
E
I
L
---
S
---
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
------------------------------------------------------------
G
A
D
F
L
-
A
S
F
L
S
E
K
----
E
F
P
T
T
S
I
H
G
D
R
L
--
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
------
P
S
-------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
--
V
G
--
N
--
N
G
R
A
T
S
F
F
D
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
36.62
15%
-81
- C1 -
3I5X
3
MS116_YEAST
A:
[54-562]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
L
I
H
V
P
K
E
D
N
S
K
E
-
V
T
L
D
S
L
L
E
E
G
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
----
S
S
E
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
---------------------
N
T
KFDSQY-----
M
V
------------
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
---
K
I
H
---
D
----
M
----
N
-------
Y
G
-
L
K
K
Y
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
--
N
K
L
R
P
N
I
-------
V
I
A
T
P
G
R
L
I
---------
D
------------
V
--
L
E
K
YSNKFFR
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
E
I
G
F
R
D
D
L
E
T
I
S
--
G
I
L
N
E
K
N
--
S
-----
K
--
S
-----
A
D
N
I
K
T
L
L
F
S
A
T
--
L
D
-
D
K
V
Q
K
L
----
A
NNIM
N
---
K
--
K
--
E
--
C
L
F
L
D
T
V
D
K
N
E
P
E
-
A
H
E
R
I
-
D
--
Q
S
V
V
I
S
E
-
K
F
A
N
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
---
D
S
N
Y
K
A
I
I
F
A
P
T
-----------------------------------------------------
V
K
F
T
S
F
L
---
C
S
I
L
-
K
N
E
F
K
K
D
-
L
P
-
I
L
E
F
-----
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
------
V
P
S
-------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
--
S
G
--
K
--
E
G
S
S
V
L
F
I
C
K
D
E
L
P
F
V
R
E
L
E
D
A
K
N
-
I
V
I
A
K
Q
E
K
Y
E
P
S
E
E
I
K
S
E
V
L
E
A
V
T
E
E
P
E
D
I
S
D
I
V
I
S
L
I
S
S
Y
R
S
C
I
K
E
Y
R
F
S
E
R
R
--
I
L
P
E
I
A
S
T
Y
G
V
L
L
N
D
P
Q
L
K
I
P
V
S
R
R
F
L
D
K
L
G
L
S
R
S
P
I
G
K
A
M
F
E
I
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
36.38
13%
-103
- C1 -
5DCA
-
BRR2_YEAST (first)
A:
[1346-1806]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
F
N
K
I
Q
S
Q
V
F
E
S
L
Y
-----
N
S
N
D
S
V
F
V
G
S
G
K
G
T
G
K
T
A
M
A
E
L
A
L
L
N
H
W
R
---------------------
Q
N-----------
K
G
------------
R
A
V
Y
I
N
P
S
G
E
K
I
D
F
L
L
S
D
W
N
---
K
R
F
---
S
----
H
LA
G
G
K
-------
I
I
N
K
L
G
N
D
P
S
L
----
N
-
L
-
K
---
L
----
L
A
K
S
H
V
-------
L
L
A
T
P
V
Q
F
E
L
L
S
R
RWRQR
K
------------
N
--
I
Q
--------
S
L
E
L
M
I
Y
D
D
A
H
E
--
I
S
Q
G
V
-
Y
G
A
V
Y
E
----
T
L
I
S
R
--
M
I
F
I
--
A
T
Q
L
-----
E
K
K
I
R
F
V
C
L
S
N
C
--
L
A
N
A
R
D
F
G
E
----
W
----
A
GMT
K
--
S
--
N
--
I
Y
N
F
S
P
S
E
R
I
E
----
P
L
E
I
-
N
--
I
Q
S
F
K
D
V
E
H
I
S
F
N
F
S
M
L
Q
M
A
F
E
A
S
A
A
A
A
---
G
N
R
N
S
S
S
V
F
L
P
S
R
K
D
C
M
E
V
A
S
A
F
M
K
F
S
K
---
A
I
E
------------------------
W
D
M
L
N
V
E
E
E
Q
I
V
P
---
Y
I
E
K
L
T
D
G
H
L
R
A
P
--
L
-
K
H
G
V
G
I
L
Y
K
G
M
A
--
S
N
D
E
R
I
V
K
R
L
Y
E
Y
G
A
V
S
V
L
L
I
S
K
D
C
S
-
A
F
A
C
K
-
T
D
E
V
I
I
L
G
T
N
L
Y
-
D
G
A
E
H
K
Y
M
P
Y
-
T
I
N
E
L
L
E
M
V
G
L
A
S
G
--
N
D
--
S
M-
A
G
K
V
L
I
L
T
S
H
N
M
K
A
Y
--------
Y
K
K
F
L
I
E
--------
P
L
P
T
E
S
Y
L
Q
Y
I
I
H
D
T
L
N
N
E
I
A
N
S
I
I
Q
S
K
--------
Q
D
C
V
D
--
W
F
T
Y
S
Y
F
Y
R
R
I
H
V
N
P
S
Y
Y
G
V
R
D
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------