@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu15730: (2016-06-24 )
MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVLTPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKYGCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETDNVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTGEELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGNETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60......-----.-----.70........80........90........100.......110.......120.......130.......140.......150.......160......-.170.......180.......190.......200.......210.......220......-.-230.......240......-----------.250..--....-------.260..--.....270......-.280.......290.......300.......310.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
R
I
V
F
MGTPDF
S
V
P
V
L
R
T
L
I
EDG
Y
E
V
V
G
V
V
TQPDRPKGRKKVLTPPP
V
K
E
E
A
L
RHGIPVLQP
E
K
V
R
-----
L
-----
T
E
E
I
E
K
V
LALKP
D
L
I
V
T
A
A
F
G
Q
I
L
P
K
E
L
LDSPKY
G
C
I
N
V
H
A
S
L
L
P
E
LRGGA
P
I
H
Y
S
I
LQGKKKT
G
I
T
I
M
Y
M
V
EKLDAGD
M
I
S
K
V
E
V
D
I
EETDNV
G
T
L
H
D
K
-
L
S
V
A
G
A
K
L
L
S
E
T
V
P
N
V
IAGSISPEKQDEEKATYAPN
I
K
R
E
Q
E
L
L
D
W
SR
T
G
E
E
L
Y
N
Q
IRGL-N-PW
P
V
A
Y
T
T
LNGQ
N
L
K
I
W
AS-----------KKIAAP--TTAE-------P
G
T
V
V
A
--
V
EKE
G
I
I
V
ATGN
E
T
-
A
L
L
L
T
ELQPAGKKRMKGED
F
V
RGAHVEAG
D
V
LGVNNEKN
28
HHSearch
79.77
69%
-104
- C4 -
4IQF
3
FMT_BACAN
A:
[4-314]
M
I
K
V
V
F
M
G
T
P
D
F
S
V
P
V
L
R
R
L
I
E
D
G
Y
D
V
I
G
V
V
T
Q
P
D
R
P
V
G
R
K
K
V
L
T
P
T
P
V
K
V
E
A
E
K
H
G
I
P
V
L
Q
P
L
R
I
R
-----
E
-----
K
D
E
Y
E
K
V
L
A
L
E
P
D
L
I
V
T
A
A
F
G
Q
I
V
P
N
E
I
L
E
A
P
K
Y
G
C
I
N
V
H
A
S
L
L
P
E
L
R
G
G
A
P
I
H
Y
A
I
M
E
G
K
E
K
T
G
I
T
I
M
Y
M
V
E
K
L
D
A
G
D
I
L
T
Q
V
E
V
E
I
E
E
R
E
T
T
G
S
L
F
D
K
-
L
S
E
A
G
A
H
L
L
S
K
T
V
P
L
L
I
Q
G
K
L
E
P
I
K
Q
N
E
E
E
V
T
F
A
Y
N
I
K
R
E
Q
E
K
I
D
W
T
K
T
G
E
E
V
Y
N
H
I
R
G
L
-
N
-
P
W
P
V
A
Y
T
T
L
A
G
Q
V
V
K
V
W
W
G
-----------
E
K
--
V
P
V
T
K
S
A
E
-------
A
G
T
I
V
A
--
I
E
E
D
G
F
V
V
A
T
G
N
-
E
T
G
V
K
I
T
E
L
Q
P
S
G
K
K
R
M
S
C
S
Q
F
L
R
G
T
K
P
E
I
G
T
K
L
G
------
1
PsiBlast_PDB
79.19
67%
-104
- C4 -
4IQF
3
FMT_BACAN
A:
[6-314]
--
K
V
V
F
M
G
T
P
D
F
S
V
P
V
L
R
R
L
I
E
D
G
Y
D
V
I
G
V
V
T
Q
P
D
R
P
V
G
R
K
K
V
L
T
P
T
P
V
K
V
E
A
E
K
H
G
I
P
V
L
Q
P
L
R
I
R
-----
E
-----
K
D
E
Y
E
K
V
L
A
L
E
P
D
L
I
V
T
A
A
F
G
Q
I
V
P
N
E
I
L
E
A
P
K
Y
G
C
I
N
V
H
A
S
L
L
P
E
L
R
G
G
A
P
I
H
Y
A
I
M
E
G
K
E
K
T
G
I
T
I
M
Y
M
V
E
K
L
D
A
G
D
I
L
T
Q
V
E
V
E
I
E
E
R
E
T
T
G
S
L
F
D
K
-
L
S
E
A
G
A
H
L
L
S
K
T
V
P
L
L
I
Q
G
K
L
E
P
I
K
Q
N
E
E
E
V
T
F
A
Y
N
I
K
R
E
Q
E
K
I
D
W
T
K
T
G
E
E
V
Y
N
H
I
R
G
L
-
N
-
P
W
P
V
A
Y
T
T
L
A
G
Q
V
V
K
V
W
W
G
-----------
E
K
V
P
V
T
--
K
S
A
E
-------
A
G
T
I
V
A
--
I
E
E
D
G
F
V
V
A
T
G
N
E
T
-
G
V
K
I
T
E
L
Q
P
S
G
K
K
R
M
S
C
S
Q
F
L
R
G
T
K
P
E
I
G
T
K
L
G
------
5
PsiBlast_PDB
71.59
44%
-119
- C4 -
3TQQ
1
FMT_COXBU
A:
[4-302]
--
K
I
V
F
A
G
T
P
Q
F
A
V
P
T
L
R
A
L
I
D
S
S
H
R
V
L
A
V
Y
T
Q
P
D
----------
E
S
P
V
K
E
I
A
R
Q
N
E
I
P
I
I
Q
P
F
S
L
R
-----
D
-----
E
V
E
Q
E
K
L
I
A
M
N
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
K
A
L
N
A
F
R
L
G
C
V
N
V
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
I
L
A
G
D
R
E
T
G
I
S
I
M
Q
M
N
E
G
L
D
T
G
D
V
L
A
K
S
A
C
V
I
S
S
E
D
T
A
A
D
L
H
D
R
-
L
S
L
I
G
A
D
L
L
L
E
S
L
A
K
L
E
K
G
D
I
K
L
E
K
Q
D
E
A
S
A
T
Y
A
S
K
I
Q
K
Q
E
A
L
I
D
W
R
K
S
A
V
E
I
A
R
Q
V
R
A
F
-
N
-
P
T
P
I
A
F
T
Y
F
E
G
Q
P
M
R
I
W
R
A
-----------
T
V
V
D
E
K
--
T
D
F
E
-------
P
G
V
L
V
D
--
A
D
K
K
G
I
S
I
A
A
G
S
G
I
--
L
R
L
H
Q
L
Q
L
P
G
K
R
V
C
S
A
G
D
F
I
-
N
A
H
--------------
29
HHSearch
70.93
44%
-121
- C4 -
3TQQ
1
FMT_COXBU
A:
[2-303]
S
L
K
I
V
F
A
G
T
P
Q
F
A
V
P
T
L
R
A
L
I
D
S
S
H
R
V
L
A
V
Y
T
Q
P
D
----------
E
S
P
V
K
E
I
A
R
Q
N
E
I
P
I
I
Q
P
F
S
L
R
-----
D
-----
E
V
E
Q
E
K
L
I
A
M
N
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
K
A
L
N
A
F
R
L
G
C
V
N
V
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
I
L
A
G
D
R
E
T
G
I
S
I
M
Q
M
N
E
G
L
D
T
G
D
V
L
A
K
S
A
C
V
I
S
S
E
D
T
A
A
D
L
H
D
R
-
L
S
L
I
G
A
D
L
L
L
E
S
L
A
K
L
E
K
G
D
I
K
L
E
K
Q
D
E
A
S
A
T
Y
A
S
K
I
Q
K
Q
E
A
L
I
D
W
R
K
S
A
V
E
I
A
R
Q
V
R
A
F
-
N
-
P
T
P
I
A
F
T
Y
F
E
G
Q
P
M
R
I
W
R
A
-----------
T
V
--
V
D
EK
T
D
F
E
-------
P
G
V
L
V
D
--
A
D
K
K
G
I
S
I
A
A
G
S
-
G
-
I
L
R
L
H
Q
L
Q
L
P
G
K
R
V
C
S
A
G
D
F
I
N
A
H
G
--------------
30
HHSearch
65.94
41%
-116
- C4 -
3Q0I
3
FMT_VIBCH
A:
[7-308]
S
L
R
I
V
F
A
G
T
P
D
F
A
A
R
H
L
A
A
L
L
S
S
E
H
E
I
I
A
V
Y
T
Q
P
E
---------
T
A
S
P
V
K
T
L
A
L
E
H
N
V
P
V
Y
Q
P
E
N
F
K
-----
S
-----
D
E
S
K
Q
Q
L
A
A
L
N
A
D
L
M
V
V
V
A
Y
G
L
L
L
P
K
V
V
L
D
T
P
K
L
G
C
I
N
V
H
G
S
I
L
P
R
W
R
G
A
A
P
I
Q
R
S
I
W
A
G
D
S
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
K
I
A
T
L
P
I
E
A
S
D
T
S
A
S
M
Y
D
K
-
L
A
E
L
G
P
Q
A
L
L
E
C
L
Q
D
I
A
Q
G
T
A
V
A
V
K
Q
D
D
G
L
A
N
Y
A
H
K
L
S
K
E
E
A
R
I
N
W
S
D
A
A
T
H
I
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
H
F
E
V
A
E
N
S
I
K
V
W
Q
A
-----------
R
V
--
E
T
RA
V
T
Q
T
-------
P
G
T
I
I
Q
--
A
D
K
S
G
I
Y
V
A
T
G
Q
-
D
-
V
L
V
L
E
S
L
Q
I
P
G
K
K
A
L
P
V
Q
D
I
L
N
A
R
A
--------------
2
PsiBlast_PDB
65.89
46%
-104
- C4 -
1FMT
-
FMT_ECOLI
A:
[5-300]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
S
G
H
N
V
V
G
V
F
T
Q
P
D
R
P
------
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
P
V
S
L
R
-----
P
-----
Q
E
N
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
-
L
A
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
K
A
-----------
S
V
I
D
T
A
--
T
N
A
A
-------
P
G
T
I
L
E
--
A
N
K
Q
G
I
Q
V
A
T
G
D
G
I
-
L
N
L
L
S
-
L
Q
P
A
G
K
K
A
M
S
A
Q
D
L
L
------------------
6
PsiBlast_PDB
65.61
40%
-116
- C4 -
3Q0I
3
FMT_VIBCH
A:
[9-306]
--
R
I
V
F
A
G
T
P
D
F
A
A
R
H
L
A
A
L
L
S
S
E
H
E
I
I
A
V
Y
T
Q
P
E
---------
T
A
S
P
V
K
T
L
A
L
E
H
N
V
P
V
Y
Q
P
E
N
F
K
-----
S
-----
D
E
S
K
Q
Q
L
A
A
L
N
A
D
L
M
V
V
V
A
Y
G
L
L
L
P
K
V
V
L
D
T
P
K
L
G
C
I
N
V
H
G
S
I
L
P
R
W
R
G
A
A
P
I
Q
R
S
I
W
A
G
D
S
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
K
I
A
T
L
P
I
E
A
S
D
T
S
A
S
M
Y
D
K
-
L
A
E
L
G
P
Q
A
L
L
E
C
L
Q
D
I
A
Q
G
T
A
V
A
V
K
Q
D
D
G
L
A
N
Y
A
H
K
L
S
K
E
E
A
R
I
N
W
S
D
A
A
T
H
I
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
H
F
E
V
A
E
N
S
I
K
V
W
Q
A
-----------
R
V
E
T
R
A
--
V
T
Q
T
-------
P
G
T
I
I
Q
--
A
D
K
S
G
I
Y
V
A
T
G
Q
D
V
--
L
V
L
E
S
L
Q
I
P
G
K
K
A
L
P
V
Q
D
I
L
N
A
----------------
31
HHSearch
64.87
45%
-103
- C4 -
1FMT
-
FMT_ECOLI
A:
[3-304]
S
L
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
S
G
H
N
V
V
G
V
F
T
Q
P
D
R
P
------
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
P
V
S
L
R
-----
P
-----
Q
E
N
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
-
L
A
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
K
A
-----------
S
V
--
I
D
TA
T
N
A
A
-------
P
G
T
I
L
E
--
A
N
K
Q
G
I
Q
V
A
T
G
D
-
G
-
I
L
N
L
L
S
L
Q
P
A
G
K
K
A
M
S
A
Q
D
L
L
N
S
R
R
--------------
4
PsiBlast_PDB
64.66
46%
-107
- C4 -
3R8X
6
FMT_YERPE
A:
[9-304]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
G
A
L
L
S
S
Q
H
K
I
V
G
V
F
T
Q
P
D
R
P
------
L
T
P
S
P
V
K
I
L
A
E
H
H
G
I
P
V
F
Q
P
K
S
L
R
-----
P
-----
E
E
N
Q
H
L
V
A
D
L
N
A
D
I
M
V
V
V
A
Y
G
L
I
L
P
A
A
V
L
A
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
V
W
A
G
D
E
K
T
G
I
T
I
M
Q
M
D
I
G
L
D
T
G
A
M
L
H
K
I
E
C
A
I
Q
P
E
D
T
S
A
T
L
Y
D
K
-
L
A
Q
L
G
P
Q
G
L
L
I
T
L
Q
Q
L
A
A
G
T
A
L
A
E
V
Q
N
E
T
Q
A
T
Y
A
E
K
L
S
K
E
E
A
K
L
D
W
T
L
S
A
T
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
V
S
Y
F
I
V
D
E
Q
P
I
K
V
W
Q
A
-----------
Q
V
L
P
A
G
--
E
D
A
E
-------
P
G
T
I
I
H
--
A
D
K
H
G
I
Q
V
A
T
A
D
G
V
--
L
N
I
T
Q
L
Q
P
A
G
K
K
A
M
S
A
A
D
L
L
------------------
32
HHSearch
64.53
30%
-127
* C4 *
2BLN
3
ARNA_ECOLI
A:
[1-304]
-
M
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
Y
E
I
S
A
I
F
T
H
T
D
---------
F
Y
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
-----
H
-----
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
-
A
D
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
S
S
-----------
R
V
--
H
P
HA
S
K
A
Q
-------
P
G
S
V
I
S
--
V
--
A
P
L
L
I
A
C
G
D
-
G
-
A
L
E
I
V
T
G
Q
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
G
L
V
Q
G
S
R
L
-------
3
PsiBlast_PDB
64.41
46%
-100
- C4 -
2FMT
1
FMT_ECOLI
A:
[5-300]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
S
G
H
N
V
V
G
V
F
T
Q
P
D
R
P
A
G
R
G
K
K
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
P
V
S
L
R
-----
P
-----
Q
E
N
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
-
L
A
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
K
A
-----------
S
V
I
D
T
A
--
T
N
A
A
-------
P
G
T
I
L
E
--
A
N
K
Q
G
I
Q
V
A
T
G
D
G
I
-
L
N
L
L
S
-
L
Q
P
A
G
K
K
A
M
S
A
Q
D
L
L
------------------
21
PsiBlast_CBE
63.59
46%
-99
- C4 -
2FMT
1
FMT_ECOLI
B:
[5-300]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
S
G
H
N
V
V
G
V
F
T
Q
P
D
R
P
A
G
R
G
K
K
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
P
V
S
L
R
-----
P
-----
Q
E
N
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
-
L
A
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
K
A
-----------
S
V
I
D
T
A
--
T
N
A
A
-------
P
G
T
I
L
E
--
A
N
K
Q
G
I
Q
V
A
T
G
D
G
I
-
L
N
L
L
S
-
L
Q
P
A
G
K
K
A
M
S
A
Q
D
L
L
------------------
34
HHSearch
59.94
30%
0
- C- -
4WKG
1
ARNA_ECOLI
A:
[1-313]
-
M
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
Y
E
I
S
A
I
F
T
H
T
D
N
P
-------
F
Y
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
-----
H
-----
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
-
A
D
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
S
S
-----------
R
V
--
H
P
HA
S
K
A
Q
-------
P
G
S
V
I
S
--
V
--
A
P
L
L
I
A
C
G
D
-
G
-
A
L
E
I
V
T
G
Q
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
G
--------------
10
PsiBlast_PDB
59.25
30%
-126
- C4 -
4WKG
1
ARNA_ECOLI
A:
[1-287]
M
K
T
V
V
F
-
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
Y
E
I
S
A
I
F
T
H
T
D
N
P
-----
F
Y
G
S
--
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
-----
H
-----
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
A
D
-
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
S
S
-----------
R
V
H
P
H
A
--
S
K
A
Q
-------
P
G
S
V
I
S
--
V
A
P
--
L
L
I
A
C
G
D
------------------------------------------
7
PsiBlast_PDB
58.88
30%
-126
- C4 -
2BLN
3
ARNA_ECOLI
A:
[1-271]
M
K
T
V
V
F
-
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
Y
E
I
S
A
I
F
T
H
T
D
-------
F
Y
G
S
--
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
-----
H
-----
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
A
D
-
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
S
S
-----------
R
V
H
P
H
A
--
S
K
A
Q
-------
P
G
S
V
I
S
--
V
A
P
--
L
L
I
A
C
G
D
------------------------------------------
8
PsiBlast_PDB
58.84
29%
-125
- C4 -
1YRW
-
ARNA_ECOLI
A:
[1-294]
M
K
T
V
V
F
-
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
Y
E
I
S
A
I
F
T
H
T
D
-------
F
Y
G
S
--
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
-----
H
-----
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
A
D
-
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
S
S
-----------
R
V
H
P
-----
K
A
Q
-------
P
G
S
V
I
S
--
V
A
P
--
L
L
I
A
C
G
-
D
G
-
A
L
E
I
V
T
G
Q
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
-----------------
9
PsiBlast_PDB
58.42
30%
-128
- C4 -
1Z7E
-
ARNA_ECOLI
A:
[1-280]
M
K
T
V
V
F
-
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
Y
E
I
S
A
I
F
T
H
T
D
---------
G
S
--
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
-----
H
-----
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
-
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
A
D
-
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
S
S
-----------
R
V
H
P
H
A
--
S
K
A
Q
-------
P
G
S
V
I
S
--
V
A
P
--
L
L
I
A
C
G
D
------------------------------------------
48
Fugue
57.01
33%
-103
- C4 -
1S3I
5
AL1L1_RAT
A:
[1-307]
-
M
K
I
A
V
I
G
Q
S
L
F
G
Q
E
V
Y
C
Q
L
R
K
E
G
H
E
V
V
G
V
F
T
I
P
D
K
D
G
K
A
------
D
P
D
G
L
E
A
E
K
D
G
V
P
V
F
K
F
P
R
W
R
ARGQA
L
-----
P
E
V
V
A
K
Y
Q
A
L
G
A
E
L
N
V
L
P
F
C
S
Q
F
I
P
M
E
V
I
N
A
P
R
H
G
S
I
I
Y
H
P
S
L
L
P
R
H
R
G
A
S
A
I
N
W
T
L
I
H
G
D
K
K
G
G
F
T
I
F
W
A
D
D
G
L
D
T
G
D
L
L
L
Q
K
E
C
E
V
L
P
D
D
T
V
S
T
L
Y
N
R
F
L
F
P
E
G
I
K
G
M
V
Q
A
V
R
L
I
A
E
G
T
A
P
R
C
P
Q
S
E
E
G
A
T
Y
E
G
I
Q
K
K
E
T
A
K
I
N
W
D
Q
P
A
E
A
I
H
N
W
I
R
G
N
-
D
-
K
V
P
G
A
W
T
E
A
C
G
Q
K
L
T
F
F
N
S
TLNTSGLSTQ
G
E
A
L
P
I
P
--
G
A
H
R
-------
P
G
V
V
T
-----
K
A
G
L
I
L
F
G
N
D
D
R
-
M
L
L
V
K
N
I
Q
L
E
D
G
K
M
M
P
A
S
Q
F
F
K
-----------------
11
PsiBlast_PDB
56.19
30%
-95
- C4 -
4QPD
3
?
A:
[2-308]
--
K
I
A
V
I
G
Q
S
L
F
G
Q
E
V
Y
K
E
L
K
N
E
G
H
M
I
V
G
V
F
T
I
P
D
K
---
D
G
K
V
---
D
P
L
A
I
E
A
E
K
D
G
V
P
V
F
K
F
P
R
W
R
-----
L
KGKAI
T
E
V
V
D
Q
Y
K
A
V
G
A
E
L
N
V
L
P
F
C
S
Q
F
I
P
M
E
V
I
D
H
P
K
H
G
S
I
I
Y
H
P
S
L
L
P
R
H
R
G
A
S
A
I
N
W
T
L
I
H
G
D
K
K
G
G
F
T
V
F
W
A
D
D
G
L
D
T
G
P
I
L
L
Q
R
E
C
D
V
E
P
N
D
N
V
N
S
I
Y
K
R
F
L
F
P
E
G
V
K
G
M
V
E
A
V
R
L
I
A
T
G
K
A
P
R
I
K
Q
P
E
E
G
A
T
Y
E
C
I
Q
K
K
E
N
S
K
I
D
W
N
Q
P
A
E
A
I
H
N
W
I
R
G
N
-
D
-
R
V
P
G
A
W
A
E
I
D
G
K
S
V
S
F
Y
G
S
-----------
T
L
L
E
N
D
--
H
F
S
S
N
G
Q
P
L
E
I
P
G
A
S
R
A
A
L
V
T
K
N
G
L
V
L
F
G
N
D
G
K
-
M
L
L
V
K
N
L
Q
F
E
D
G
K
M
I
P
G
S
Q
Y
F
K
-----------------
15
PsiBlast_PDB
55.97
30%
-102
- C4 -
1S3I
5
AL1L1_RAT
A:
[2-307]
--
K
I
A
V
I
G
Q
S
L
F
G
Q
E
V
Y
C
Q
L
R
K
E
G
H
E
V
V
G
V
F
T
I
P
D
K
-
D
G
K
A
D
-----
P
D
G
L
E
A
E
K
D
G
V
P
V
F
K
F
P
R
W
R
ARGQA
L
-----
P
E
V
V
A
K
Y
Q
A
L
G
A
E
L
N
V
L
P
F
C
S
Q
F
I
P
M
E
V
I
N
A
P
R
H
G
S
I
I
Y
H
P
S
L
L
P
R
H
R
G
A
S
A
I
N
W
T
L
I
H
G
D
K
K
G
G
F
T
I
F
W
A
D
D
G
L
D
T
G
D
L
L
L
Q
K
E
C
E
V
L
P
D
D
T
V
S
T
L
Y
N
R
F
L
F
P
E
G
I
K
G
M
V
Q
A
V
R
L
I
A
E
G
T
A
P
R
C
P
Q
S
E
E
G
A
T
Y
E
G
I
Q
K
K
E
T
A
K
I
N
W
D
Q
P
A
E
A
I
H
N
W
I
R
G
N
-
D
-
K
V
P
G
A
W
T
E
A
C
G
Q
K
L
T
F
F
N
S
TLNTSGLSTQ
G
E
A
L
P
I
P
--
G
A
H
R
-------
P
G
V
V
T
-----
K
A
G
L
I
L
F
G
N
D
D
R
-
M
L
L
V
K
N
I
Q
L
E
D
G
K
M
M
P
A
S
Q
F
F
K
-----------------