@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu16710: (2016-06-26 )
MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGISHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVLADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTEETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEKPEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVREDKGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENSKEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLFTEDYALALISPSGNMPS
Atome Classification :
(26 SA)
.........10.....--...20........30........40........50.......-.60........70........80........90........100.......110.......120.......130.......140----........150.......160---.........170.----......180.......190.-..-....200--...----..---..210...-.---..-.--220----.--.-.-----......230....-....240.......250.......260--------..---------.-----------.....-270.......280.......290-.......300......--...310.......320.--.......330.......340.......350.......360...-....370.......380.....-..390.---------.-.....400.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
K
R
Y
TCQN
G
V
R
I
V
LE--NNP
T
V
R
S
V
A
I
G
V
W
I
GTGSRHETPEI
N
G
I
S
H
F
L
E
H
M
FFKGTST-
K
S
A
R
E
I
A
E
S
F
D
R
IGGQ
V
N
A
F
TSK
E
Y
T
C
Y
Y
A
K
V
L
D
EHA
N
Y
A
L
D
V
L
A
D
M
F
F
HSTF
D
E
N
E
L
K
K
E
K
N
V
V
Y
E
E
I
K
M
YEDA
P
D
D
I
V
H
D
L
-----
L
S
K
ATYGNHSLGYPILG
T
E
-----
E
T
L
A
SF
N
G
D
S
L
R
Q
----
Y
M
H
D
YYTP
D
R
V
V
I
S
V
AGNI
S
-
D
S
-
F
I
K
D
V
E
K
--
W
F
G
----SY---EAKGKATG-L---EK-P--E------
F
--
H
-
T
-----
E
K
L
TRKKE-TEQA-
H
L
C
L
GFK
G
L
E
V
G
H
E
R
I
Y
D
L
I
V
L
N
N
VL---------GG---------
S
-----------
M
S
S
R
L
-
F
Q
D
V
R
EDKG
L
A
Y
S
V
Y
S
YHSSYED-S
G
M
L
T
I
YG--GT
G
A
N
Q
--
L
Q
Q
L
S
E
T
I
Q
E
T
L
A
T
-
L
K
--RDGI
T
S
K
E
L
E
N
S
K
E
Q
MKG
S
L
M
L
S
L
ESTN
S
K
MSRNGKN
E
L
L
LGK-H
K
T
L
D
E
I
I
N
E
L
NAV
N
L
E
R
V
N
G
L
-
A
R
Q
L
FT---------E-D
Y
A
L
A
L
ISPSGNMPS
21
PsiBlast_CBE
95.44
64%
-84
* C2 *
3HDI
5
?
B:
[2-408]
-
I
N
T
M
T
L
D
N
G
V
R
I
I
T
E
--
K
M
S
T
V
R
S
V
S
I
G
I
W
V
G
T
G
S
R
Y
E
S
A
E
E
N
G
I
S
H
F
L
E
H
M
F
F
K
G
T
N
T
-
R
S
A
Q
E
I
A
E
F
F
D
S
I
G
G
Q
V
N
A
F
T
S
K
E
Y
T
C
Y
Y
A
K
V
L
D
D
H
A
G
Q
A
I
D
T
L
S
D
M
F
F
H
S
T
F
Q
K
E
E
L
E
K
E
R
K
V
V
F
E
E
I
K
M
V
D
D
T
P
D
D
I
V
H
D
L
-----
L
S
S
A
T
Y
G
K
H
S
L
G
Y
P
I
L
G
T
V
-----
E
T
L
N
S
F
N
E
G
M
L
R
H
----
Y
M
D
R
F
Y
T
G
D
Y
V
V
I
S
V
A
G
N
V
H
-
D
E
-
L
I
D
K
I
K
E
--
T
F
S
----
Q
V
---
K
P
T
T
Y
N
Y
Q
-
G
---
E
K
-
P
--
M
------
F
--
L
-
P
-----
N
R
I
V
R
K
K
E
-
T
E
Q
A
-
H
L
C
L
G
Y
P
G
L
P
I
G
D
K
D
V
Y
A
L
V
L
L
N
N
V
L
---------
G
G
---------
S
-----------
M
S
S
R
L
-
F
Q
D
I
R
E
K
R
G
L
C
Y
S
V
F
S
Y
H
S
S
F
R
D
-
S
G
M
L
T
I
Y
A
--
G
T
G
H
D
Q
--
L
D
D
L
V
Y
S
I
Q
E
T
T
S
A
-
L
A
--
E
K
G
L
T
E
K
E
L
E
N
G
K
E
Q
L
K
G
S
L
M
L
S
L
E
S
T
N
S
R
M
S
R
N
G
K
N
E
L
L
L
K
K
-
H
R
S
L
D
E
M
I
E
Q
I
N
A
V
Q
K
Q
D
V
S
R
L
-
A
K
I
L
L
S
---------
A
-
S
P
S
I
S
L
I
N
A
N
G
E
L
P
-
1
PsiBlast_PDB
94.63
64%
-80
- C2 -
3HDI
7
?
A:
[2-408]
-
I
N
T
M
T
L
D
N
G
V
R
I
I
T
E
--
K
M
S
T
V
R
S
V
S
I
G
I
W
V
G
T
G
S
R
Y
E
S
A
E
E
N
G
I
S
H
F
L
E
H
M
F
F
K
G
T
N
T
-
R
S
A
Q
E
I
A
E
F
F
D
S
I
G
G
Q
V
N
A
F
T
S
K
E
Y
T
C
Y
Y
A
K
V
L
D
D
H
A
G
Q
A
I
D
T
L
S
D
M
F
F
H
S
T
F
Q
K
E
E
L
E
K
E
R
K
V
V
F
E
E
I
K
M
V
D
D
T
P
D
D
I
V
H
D
L
-----
L
S
S
A
T
Y
G
K
H
S
L
G
Y
P
I
L
G
T
V
-----
E
T
L
N
S
F
N
E
G
M
L
R
H
----
Y
M
D
R
F
Y
T
G
D
Y
V
V
I
S
V
A
G
N
V
H
-
D
E
-
L
I
D
K
I
K
E
--
T
F
S
----
Q
V
---
K
P
T
T
Y
N
Y
Q
-
G
---
E
K
-
P
--
M
------
F
--
L
-
P
-----
N
R
I
V
R
K
K
E
-
T
E
Q
A
-
H
L
C
L
G
Y
P
G
L
P
I
G
D
K
D
V
Y
A
L
V
L
L
N
N
V
L
---------
G
G
---------
S
-----------
M
S
S
R
L
-
F
Q
D
I
R
E
K
R
G
L
C
Y
S
V
F
S
Y
H
S
S
F
R
D
-
S
G
M
L
T
I
Y
A
--
G
T
G
H
D
Q
--
L
D
D
L
V
Y
S
I
Q
E
T
T
S
A
-
L
A
--
E
K
G
L
T
E
K
E
L
E
N
G
K
E
Q
L
K
G
S
L
M
L
S
L
E
S
T
N
S
R
M
S
R
N
G
K
N
E
L
L
L
K
K
-
H
R
S
L
D
E
M
I
E
Q
I
N
A
V
Q
K
Q
D
V
S
R
L
-
A
K
I
L
L
S
---------
A
-
S
P
S
I
S
L
I
N
A
N
G
E
L
P
-
97
HHSearch
93.14
63%
-79
- C2 -
3HDI
7
?
A:
[2-409]
-
I
N
T
M
T
L
D
N
G
V
R
I
I
T
E
--
K
M
S
T
V
R
S
V
S
I
G
I
W
V
G
T
G
S
R
Y
E
S
A
E
E
N
G
I
S
H
F
L
E
H
M
F
F
K
G
T
N
T
-
R
S
A
Q
E
I
A
E
F
F
D
S
I
G
G
Q
V
N
A
F
T
S
K
E
Y
T
C
Y
Y
A
K
V
L
D
D
H
A
G
Q
A
I
D
T
L
S
D
M
F
F
H
S
T
F
Q
K
E
E
L
E
K
E
R
K
V
V
F
E
E
I
K
M
V
D
D
T
P
D
D
I
V
H
D
L
-----
L
S
S
A
T
Y
G
K
H
S
L
G
Y
P
I
L
G
T
V
-----
E
T
L
N
S
F
N
E
G
M
L
R
H
----
Y
M
D
R
F
Y
T
G
D
Y
V
V
I
S
V
A
G
N
V
H
-
D
E
-
L
I
D
K
I
K
E
--
T
F
S
----
Q
V
---
K
P
T
T
Y
N
-
Y
-
Q
---
G
E
-
K
--
P
M
-----
F
--
L
-
P
-----
N
R
I
V
R
K
K
E
-
T
E
Q
A
-
H
L
C
L
G
Y
P
G
L
P
I
G
D
K
D
V
Y
A
L
V
L
L
N
N
V
L
---------
G
G
---------
S
-----------
M
S
S
R
L
-
F
Q
D
I
R
E
K
R
G
L
C
Y
S
V
F
S
Y
H
S
S
F
R
D
-
S
G
M
L
T
I
Y
A
--
G
T
G
H
D
Q
--
L
D
D
L
V
Y
S
I
Q
E
T
T
S
A
-
L
A
--
E
K
G
L
T
E
K
E
L
E
N
G
K
E
Q
L
K
G
S
L
M
L
S
L
E
S
T
N
S
R
M
S
R
N
G
K
N
-
E
L
L
L
K
K
H
R
S
L
D
E
M
I
E
Q
I
N
A
V
Q
K
Q
D
V
S
R
L
-
A
K
I
L
L
S
---------
A
-
S
P
S
I
S
L
I
N
A
N
G
E
L
P
K
19
PsiBlast_PDB
77.51
25%
-94
- C2 -
3L72
-
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
E
S
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V
---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
16
PsiBlast_PDB
76.87
25%
-96
- C2 -
3H1L
1
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
ES
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V
---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
18
PsiBlast_PDB
76.65
25%
-95
- C2 -
3L71
-
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
E
S
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
15
PsiBlast_PDB
76.43
25%
-96
- C2 -
3H1K
1
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
E
S
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
107
HHSearch
76.13
25%
-84
- C2 -
1HR6
1
MPPA_YEAST
A:
[6-441]
-
F
K
L
S
S
L
A
N
G
L
K
V
A
T
S
--
N
T
P
G
-
H
F
S
A
L
G
L
Y
I
D
A
G
S
R
F
E
G
R
N
L
K
G
C
T
H
I
L
D
R
L
A
F
K
S
T
E
H
-
V
E
G
R
A
M
A
E
T
L
E
L
L
G
G
N
Y
Q
C
T
S
S
R
E
N
L
M
Y
Q
A
S
V
F
N
Q
D
V
G
K
M
L
Q
L
M
S
E
T
V
R
F
P
K
I
T
E
Q
E
L
Q
E
Q
K
L
S
A
E
Y
E
I
D
E
V
W
M
K
P
E
L
V
L
P
E
L
-----
L
H
T
A
A
Y
S
G
E
T
L
G
S
P
L
I
C
P
R
-----
G
L
I
P
S
I
S
K
Y
Y
L
L
D
----
Y
R
N
K
F
Y
T
P
E
N
T
V
A
A
F
V
G
-
V
P
-
H
E
K
A
L
E
L
T
G
K
--
Y
L
G
----
D
W
---
Q
S
T
H
P
P
-
I
-
T
---
K
K
V
A
--
Q
------
Y
T
-
G
-
G
E
S
C
I
P
P
A
P
V
F
G
N
L
-
P
E
L
F
-
H
I
Q
I
G
F
E
G
L
P
I
D
H
P
D
I
Y
A
L
A
T
L
Q
T
L
L
---------
G
G
---------
G
G
S
F
S
A
G
G
P
GKG
M
Y
S
R
L
-
Y
T
H
V
L
N
Q
Y
Y
F
V
E
N
C
V
A
F
N
H
S
Y
S
D
-
S
G
I
F
G
I
S
L
--
S
C
I
P
Q
A
--
A
P
Q
A
V
E
V
I
A
Q
Q
M
Y
N
T
F
A
NK
D
L
R
L
T
E
D
E
V
S
R
A
K
N
Q
L
K
S
S
L
L
M
N
L
E
S
K
L
V
E
L
E
D
M
G
R
Q
-
V
L
M
H
G
R
K
I
P
V
N
E
M
I
S
K
I
E
D
L
K
P
D
D
I
S
R
V
-
A
E
M
I
F
T
GNVNNAGNG
K
G
R
A
T
V
V
M
Q
G
D
R
G
S
F
G
-
17
PsiBlast_PDB
75.64
25%
-95
- C2 -
3L70
-
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
E
S
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
12
PsiBlast_PDB
75.54
25%
-92
- C2 -
3H1H
2
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
E
S
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
13
PsiBlast_PDB
75.48
25%
-93
- C2 -
3H1I
-
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
E
S
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V
---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
20
PsiBlast_PDB
74.92
25%
-93
- C2 -
3L73
-
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
E
S
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
11
PsiBlast_PDB
74.25
25%
-94
- C2 -
3CWB
-
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
E
S
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
14
PsiBlast_PDB
74.15
25%
-89
- C2 -
3H1J
-
?
A:
[18-427]
-----
T
L
D
N
G
L
R
V
A
S
E
E
S
S
Q
P
T
C
---
T
V
G
V
W
I
G
A
G
S
R
Y
E
N
E
K
N
N
G
A
G
Y
F
V
E
H
L
A
F
K
G
T
K
K
-
R
P
C
A
A
F
E
K
E
V
E
S
M
G
A
H
F
N
G
Y
T
S
R
E
Q
T
A
F
Y
I
K
A
L
S
K
D
M
P
K
V
V
E
L
L
A
D
V
V
Q
N
C
A
L
E
E
S
Q
I
E
K
E
R
G
V
I
L
Q
E
L
K
E
M
D
N
D
M
T
N
V
T
F
D
Y
-----
L
H
A
T
A
F
Q
G
T
A
L
A
R
T
V
E
G
T
T
-----
E
N
I
K
H
L
T
R
A
D
L
A
S
----
Y
I
D
T
H
F
K
A
P
R
M
V
L
A
A
A
G
G
I
S
-
H
K
-
E
L
V
D
A
A
R
Q
H
F
S
G
V
---
S
F
---
T
Y
K
E
D
A
V
P
I
L
---
P
R
-
C
--
R
------
F
--
T
G
S
-----
E
I
R
A
R
D
D
A
-
L
P
V
A
-
H
V
A
L
A
V
E
G
P
G
W
A
D
P
D
N
V
V
L
H
V
A
N
A
I
I
G
R
Y
D
RTFGG
G
K
---------
H
-----------
L
S
S
R
L
-
A
A
L
A
V
E
H
K
-
L
C
H
S
F
Q
T
F
N
T
S
Y
S
D
-
T
G
L
F
G
F
H
F
--
V
A
D
P
L
S
--
I
D
D
M
M
F
C
A
Q
G
E
W
M
R
-
L
C
---
T
S
T
T
E
S
E
V
K
R
A
K
N
H
L
R
S
A
M
V
A
Q
L
D
G
T
T
P
V
C
E
T
I
G
S
H
L
L
N
Y
G
R
-
R
I
S
L
E
E
W
D
S
R
I
S
A
V
D
A
R
M
V
R
D
V
C
S
K
Y
I
Y
D
---------
K
-
C
P
A
L
A
A
V
G
P
------
6
PsiBlast_PDB
73.34
31%
-86
- C2 -
3EOQ
-
?
A:
[7-405]
------
L
R
N
G
L
R
V
I
A
E
--
V
V
P
G
A
R
S
V
A
L
G
Y
F
V
K
T
G
A
R
D
E
T
K
E
E
S
G
V
S
H
F
L
E
H
M
V
F
K
G
P
E
D
-
M
D
A
L
A
V
N
R
A
F
D
R
M
G
A
Q
Y
N
A
F
T
S
E
E
A
T
V
Y
Y
G
A
V
L
P
E
F
A
Y
D
L
L
G
L
F
A
K
L
-
L
R
P
A
L
R
E
E
D
F
Q
T
E
K
L
V
I
L
E
E
I
A
R
Y
Q
D
R
P
G
F
M
A
Y
E
W
-----
A
R
A
R
F
F
Q
G
H
P
L
G
N
S
V
L
G
T
R
-----
E
S
I
T
A
L
T
R
E
G
M
A
A
----
Y
H
R
R
R
Y
L
P
K
N
M
V
L
A
A
T
G
R
V
D
F
D
R
-
L
L
A
E
A
E
R
--
L
T
E
----
A
W
P
E
G
E
A
E
-
R
A
Y
P
-
P
---
L
T
-
P
--
A
------
F
--
G
-
V
-----
E
E
--
R
P
Y
E
-
K
A
R
A
L
Y
L
V
A
L
F
P
G
V
A
Y
Q
E
E
A
R
F
P
G
Q
V
L
A
H
L
L
---------
G
E
---------
E
-----------
G
S
G
R
L
H
F
A
L
V
--
D
K
G
L
A
-
E
V
A
S
F
G
L
E
E
A
D
R
A
G
T
F
H
A
Y
V
--
Q
A
D
P
A
R
--
K
G
E
V
L
A
V
L
Q
E
E
L
D
R
-
L
G
--
R
E
G
V
G
E
E
E
V
E
R
A
K
T
P
L
A
T
G
L
V
F
A
G
E
T
P
M
Q
R
L
F
H
L
G
M
E
Y
L
Y
T
G
R
-
Y
L
S
L
E
E
V
K
A
R
V
Q
R
V
T
S
R
E
V
N
A
L
-
L
E
R
G
F
L
---------
E
-
K
G
L
Y
Y
L
V
L
P
H
G
----
8
PsiBlast_PDB
72.71
23%
-89
- C2 -
1BCC
-
QCR1_BOVIN (first)
A:
[21-432]
--------
N
G
V
R
V
A
S
E
--
Q
S
-
S
Q
P
T
C
T
V
G
V
W
I
D
A
G
S
R
Y
E
S
E
K
N
N
G
A
G
Y
F
L
E
H
L
A
F
K
G
T
K
N
-
R
P
Q
N
A
L
E
K
E
V
E
S
M
G
A
H
L
N
A
Y
S
S
R
E
H
T
A
Y
Y
I
K
A
L
S
K
D
V
P
K
A
V
E
L
L
A
D
I
V
Q
N
C
S
L
E
D
S
Q
I
E
K
E
R
D
V
I
V
R
E
L
Q
E
N
D
T
S
M
R
E
V
V
F
N
Y
-----
L
H
A
T
A
F
Q
G
T
G
L
A
Q
S
V
E
G
P
S
-----
E
N
I
R
K
L
S
R
A
D
L
T
E
----
Y
L
S
T
H
Y
T
A
P
R
M
V
L
A
A
A
G
G
V
E
H
Q
Q
-
L
L
E
L
A
Q
K
--
H
F
G
G
V
P
F
T
Y
---
D
D
D
A
V
P
T
--
L
---
S
K
-
C
--
R
------
F
--
T
-
G
-----
S
Q
I
R
H
R
E
D
G
L
P
L
A
-
H
V
A
I
A
V
E
G
P
G
W
A
H
P
D
L
V
A
L
Q
V
A
N
A
I
I
G
H
Y
D
RTYG-
G
G
---------
L
-----------
H
S
S
S
P
-
L
A
S
I
A
V
T
N
K
L
C
Q
S
F
Q
T
F
S
I
C
Y
S
E
-
T
G
L
F
G
F
Y
F
--
V
C
D
R
M
S
--
I
D
D
M
M
F
V
L
Q
G
Q
W
M
R
-
L
C
---
T
S
I
S
E
S
E
V
L
R
G
K
N
F
L
R
N
A
L
V
S
H
L
D
G
T
T
P
V
C
E
D
I
G
R
E
L
L
T
Y
G
R
-
R
I
P
L
E
E
W
E
E
R
L
A
E
V
D
A
R
M
V
R
E
V
C
S
K
Y
I
Y
D
---------
Q
-
C
P
A
V
A
G
P
G
P
I
E
Q
L
P
-
3
PsiBlast_PDB
71.91
26%
-77
- C2 -
1HR7
1
MPPB_YEAST
B:
[14-402]
--------
N
G
L
T
I
A
T
E
--
Y
I
P
N
T
S
S
A
T
V
G
I
F
V
D
A
G
S
R
A
E
N
V
K
N
N
G
T
A
H
F
L
Q
H
L
A
F
K
G
T
Q
N
-
R
P
Q
Q
G
I
E
L
E
I
E
N
I
G
S
H
L
N
A
Y
T
S
R
E
N
T
V
Y
Y
A
K
S
L
Q
E
D
I
P
K
A
V
D
I
L
S
D
I
L
T
K
S
V
L
D
N
S
A
I
E
R
E
R
D
V
I
I
R
E
S
E
E
V
D
K
M
Y
D
E
V
V
F
D
H
-----
L
H
E
I
T
Y
K
D
Q
P
L
G
R
T
I
L
G
P
I
-----
K
N
I
K
S
I
T
R
T
D
L
K
D
----
Y
I
T
K
N
Y
K
G
D
R
M
V
L
A
G
A
G
A
V
D
H
E
K
-
L
V
Q
Y
A
Q
K
--
Y
F
G
----
H
V
---
P
K
S
E
S
P
V
P
-
L
---
G
S
-
P
--
R
GP
L
P
V
F
C
--
R
-
G
-----
E
R
F
I
K
E
N
T
-
L
P
T
T
-
H
I
A
I
A
L
E
G
V
S
W
S
A
P
D
Y
F
V
A
L
A
T
Q
A
I
V
---------
G
N
W
D
RAIGTGT
N
-----------
S
P
S
P
L
-
A
V
A
A
S
Q
N
G
S
L
A
N
S
Y
M
S
F
S
T
S
Y
A
D
-
S
G
L
W
G
M
Y
I
--
V
T
D
S
N
E
HN
V
R
L
I
V
N
E
I
L
K
E
W
K
R
-
I
K
--
S
G
K
I
S
D
A
E
V
N
R
A
K
A
Q
L
K
A
A
L
L
L
S
L
D
G
S
T
A
I
V
E
D
I
G
R
Q
V
V
T
T
G
K
-
R
L
S
P
E
E
V
F
E
Q
V
D
K
I
-----------------------------------------
100
HHSearch
71.56
25%
-75
- C2 -
1HR6
1
MPPB_YEAST
B:
[7-433]
-
T
R
T
S
K
L
P
N
G
L
T
I
A
T
E
--
Y
I
P
N
T
S
S
A
T
V
G
I
F
V
D
A
G
S
R
A
E
N
V
K
N
N
G
T
A
H
F
L
E
H
L
A
F
K
G
T
Q
N
-
R
P
Q
Q
G
I
E
L
E
I
E
N
I
G
S
H
L
N
A
Y
T
S
R
E
N
T
V
Y
Y
A
K
S
L
Q
E
D
I
P
K
A
V
D
I
L
S
D
I
L
T
K
S
V
L
D
N
S
A
I
E
R
E
R
D
V
I
I
R
E
S
E
E
V
D
K
M
Y
D
E
V
V
F
D
H
-----
L
H
E
I
T
Y
K
D
Q
P
L
G
R
T
I
L
G
P
I
-----
K
N
I
K
S
I
T
R
T
D
L
K
D
----
Y
I
T
K
N
Y
K
G
D
R
M
V
L
A
G
A
G
A
V
D
-
H
E
K
L
V
Q
Y
A
Q
K
--
Y
F
G
----
H
V
---
P
K
S
E
S
P
-
V
-
P
LGS
P
R
-
G
P
L
P
------
V
F
C
R
-
G
-----
E
R
F
I
K
E
N
T
-
L
P
T
T
-
H
I
A
I
A
L
E
G
V
S
W
S
A
P
D
Y
F
V
A
L
A
T
Q
A
I
V
---------
G
N
W
D
RAIGT--
G
TN---------
S
P
S
P
L
-
A
V
A
A
S
Q
N
G
S
L
A
N
S
Y
M
S
F
S
T
S
Y
A
D
-
S
G
L
W
G
M
Y
I
V
T
D
S
N
E
H
N
--
V
R
L
I
V
N
E
I
L
K
E
W
K
R
-
I
K
--
S
G
K
I
S
D
A
E
V
N
R
A
K
A
Q
L
K
A
A
L
L
L
S
L
D
G
S
T
A
I
V
E
D
I
G
R
Q
-
V
V
T
T
G
K
R
L
S
P
E
E
V
F
E
Q
V
D
K
I
T
K
D
D
I
I
M
W
-
A
N
Y
R
L
Q
---------
N
K
P
V
S
M
V
A
L
G
N
T
S
T
V
P
N
5
PsiBlast_PDB
71.52
26%
-77
- C2 -
1HR9
2
MPPB_YEAST
B:
[14-402]
--------
N
G
L
T
I
A
T
E
--
Y
I
P
N
T
S
S
A
T
V
G
I
F
V
D
A
G
S
R
A
E
N
V
K
N
N
G
T
A
H
F
L
Q
H
L
A
F
K
G
T
Q
N
-
R
P
Q
Q
G
I
E
L
E
I
E
N
I
G
S
H
L
N
A
Y
T
S
R
E
N
T
V
Y
Y
A
K
S
L
Q
E
D
I
P
K
A
V
D
I
L
S
D
I
L
T
K
S
V
L
D
N
S
A
I
E
R
E
R
D
V
I
I
R
E
S
E
E
V
D
K
M
Y
D
E
V
V
F
D
H
-----
L
H
E
I
T
Y
K
D
Q
P
L
G
R
T
I
L
G
P
I
-----
K
N
I
K
S
I
T
R
T
D
L
K
D
----
Y
I
T
K
N
Y
K
G
D
R
M
V
L
A
G
A
G
A
V
D
H
E
K
-
L
V
Q
Y
A
Q
K
--
Y
F
G
----
H
V
---
P
K
S
E
S
P
V
P
-
L
---
G
S
-
P
--
R
GP
L
P
V
F
C
--
R
-
G
-----
E
R
F
I
K
E
N
T
-
L
P
T
T
-
H
I
A
I
A
L
E
G
V
S
W
S
A
P
D
Y
F
V
A
L
A
T
Q
A
I
V
---------
G
N
W
D
RAIGTGT
N
-----------
S
P
S
P
L
-
A
V
A
A
S
Q
N
G
S
L
A
N
S
Y
M
S
F
S
T
S
Y
A
D
-
S
G
L
W
G
M
Y
I
--
V
T
D
S
N
E
HN
V
R
L
I
V
N
E
I
L
K
E
W
K
R
-
I
K
--
S
G
K
I
S
D
A
E
V
N
R
A
K
A
Q
L
K
A
A
L
L
L
S
L
D
G
S
T
A
I
V
E
D
I
G
R
Q
V
V
T
T
G
K
-
R
L
S
P
E
E
V
F
E
Q
V
D
K
I
-----------------------------------------
10
PsiBlast_PDB
71.51
23%
-85
- C2 -
2BCC
-
QCR1_BOVIN
A:
[21-432]
--------
N
G
V
R
V
A
S
E
--
Q
S
-
S
Q
P
T
C
T
V
G
V
W
I
D
A
G
S
R
Y
E
S
E
K
N
N
G
A
G
Y
F
L
E
H
L
A
F
K
G
T
K
N
-
R
P
Q
N
A
L
E
K
E
V
E
S
M
G
A
H
L
N
A
Y
S
S
R
E
H
T
A
Y
Y
I
K
A
L
S
K
D
V
P
K
A
V
E
L
L
A
D
I
V
Q
N
C
S
L
E
D
S
Q
I
E
K
E
R
D
V
I
V
R
E
L
Q
E
N
D
T
S
M
R
E
V
V
F
N
Y
-----
L
H
A
T
A
F
Q
G
T
G
L
A
Q
S
V
E
G
P
S
-----
E
N
I
R
K
L
S
R
A
D
L
T
E
----
Y
L
S
T
H
Y
T
A
P
R
M
V
L
A
A
A
G
G
V
E
H
Q
Q
-
L
L
E
L
A
Q
K
--
H
F
G
G
V
P
F
T
Y
---
D
D
D
A
V
P
T
--
L
---
S
K
-
C
--
R
------
F
--
T
-
G
-----
S
Q
I
R
H
R
E
D
G
L
P
L
A
-
H
V
A
I
A
V
E
G
P
G
W
A
H
P
D
L
V
A
L
Q
V
A
N
A
I
I
G
H
Y
D
RTYG-
G
G
---------
L
-----------
H
S
S
S
P
-
L
A
S
I
A
V
T
N
K
L
C
Q
S
F
Q
T
F
S
I
C
Y
S
E
-
T
G
L
F
G
F
Y
F
--
V
C
D
R
M
S
--
I
D
D
M
M
F
V
L
Q
G
Q
W
M
R
-
L
C
---
T
S
I
S
E
S
E
V
L
R
G
K
N
F
L
R
N
A
L
V
S
H
L
D
G
T
T
P
V
C
E
D
I
G
R
E
L
L
T
Y
G
R
-
R
I
P
L
E
E
W
E
E
R
L
A
E
V
D
A
R
M
V
R
E
V
C
S
K
Y
I
Y
D
---------
Q
-
C
P
A
V
A
G
P
G
P
I
E
Q
L
P
-
40
PsiBlast_CBE
53.84
31%
-76
- C2 -
2WK3
2
IDE_HUMAN
A:
[71-300]
--------
N
G
I
K
V
L
L
I
--
S
D
P
T
T
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
L
Q
H
M
L
F
L
G
T
K
K
Y
P
K
E
N
E
Y
S
Q
F
L
S
E
H
A
G
S
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
E
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
L
F
D
E
S
A
K
D
R
E
V
N
A
V
D
S
E
H
E
------
K
N
V
M
N
D
A
W
R
L
F
Q
L
E
K
A
T
-
G
N
P
K
H
P
F
S
K
F
G
T
G
NKYTL
E
T
R
P
N
Q
E
G
I
D
V
R
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
V
V
L
G
R
E
S
L
D
D
-
L
T
N
L
V
V
K
--
L
F
S
----
E
V
---
E
N
K
----
N
-
V
---
P
L
-
P
--
E
------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
53.06
31%
-77
- C2 -
2WBY
3
IDE_HUMAN
A:
[42-272]
--------
N
G
I
K
V
L
L
I
--
S
D
P
T
T
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
L
Q
H
M
L
F
L
G
T
K
K
Y
P
K
E
N
E
Y
S
Q
F
L
S
E
H
A
G
S
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
E
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
L
F
D
E
S
A
K
D
R
E
V
N
A
V
D
S
E
H
E
------
K
N
V
M
N
D
A
W
R
L
F
Q
L
E
K
A
T
-
G
N
P
K
H
P
F
S
K
F
G
T
G
NKYTL
E
T
R
P
N
Q
E
G
I
D
V
R
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
V
V
L
G
R
E
S
L
D
D
-
L
T
N
L
V
V
K
--
L
F
S
----
E
V
---
E
N
K
----
N
-
V
---
P
L
-
P
--
E
------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
51.62
31%
-78
- C2 -
2WC0
4
IDE_HUMAN (first)
A:
[42-276]
--------
N
G
I
K
V
L
L
I
--
S
D
P
T
T
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
L
Q
H
M
L
F
L
G
T
K
K
Y
P
K
E
N
E
Y
S
Q
F
L
S
E
H
A
G
S
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
E
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
L
F
D
E
S
A
K
D
R
E
V
N
A
V
D
S
E
H
E
------
K
N
V
M
N
D
A
W
R
L
F
Q
L
E
K
A
T
-
G
N
P
K
H
P
F
S
K
F
G
T
G
NKYTL
E
T
R
P
N
Q
E
G
I
D
V
R
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
V
V
L
G
R
E
S
L
D
D
-
L
T
N
L
V
V
K
--
L
F
S
----
E
V
---
E
N
K
----
N
-
V
---
P
L
-
P
--
E
------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
51.38
31%
-77
- C2 -
2WC0
4
IDE_HUMAN
B:
[42-274]
--------
N
G
I
K
V
L
L
I
--
S
D
P
T
T
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
L
Q
H
M
L
F
L
G
T
K
K
Y
P
K
E
N
E
Y
S
Q
F
L
S
E
H
A
G
S
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
E
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
L
F
D
E
S
A
K
D
R
E
V
N
A
V
D
S
E
H
E
------
K
N
V
M
N
D
A
W
R
L
F
Q
L
E
K
A
T
-
G
N
P
K
H
P
F
S
K
F
G
T
G
NKYTL
E
T
R
P
N
Q
E
G
I
D
V
R
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
V
V
L
G
R
E
S
L
D
D
-
L
T
N
L
V
V
K
--
L
F
S
----
E
V
---
E
N
K
----
N
-
V
---
P
L
-
P
--
E
------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
51.32
31%
-78
- C2 -
2WBY
3
IDE_HUMAN
B:
[42-273]
--------
N
G
I
K
V
L
L
I
--
S
D
P
T
T
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
L
Q
H
M
L
F
L
G
T
K
K
Y
P
K
E
N
E
Y
S
Q
F
L
S
E
H
A
G
S
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
E
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
L
F
D
E
S
A
K
D
R
E
V
N
A
V
D
S
E
H
E
------
K
N
V
M
N
D
A
W
R
L
F
Q
L
E
K
A
T
-
G
N
P
K
H
P
F
S
K
F
G
T
G
NKYTL
E
T
R
P
N
Q
E
G
I
D
V
R
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
V
V
L
G
R
E
S
L
D
D
-
L
T
N
L
V
V
K
--
L
F
S
----
E
V
---
E
N
K
----
N
-
V
---
P
L
-
P
--
E
------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
50.30
31%
-76
- C2 -
2WK3
2
IDE_HUMAN
B:
[71-301]
--------
N
G
I
K
V
L
L
I
--
S
D
P
T
T
D
K
S
S
A
A
L
D
V
H
I
G
S
L
S
D
P
P
N
I
A
G
L
S
H
F
L
Q
H
M
L
F
L
G
T
K
K
Y
P
K
E
N
E
Y
S
Q
F
L
S
E
H
A
G
S
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
H
E
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
L
F
D
E
S
A
K
D
R
E
V
N
A
V
D
S
E
H
E
------
K
N
V
M
N
D
A
W
R
L
F
Q
L
E
K
A
T
-
G
N
P
K
H
P
F
S
K
F
G
T
G
NKYTL
E
T
R
P
N
Q
E
G
I
D
V
R
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
N
L
M
A
V
V
V
L
G
R
E
S
L
D
D
-
L
T
N
L
V
V
K
--
L
F
S
----
E
V
---
E
N
K
----
N
-
V
---
P
L
-
P
--
E
------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------