@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17120: (2016-06-27 )
MITYVFPGQGSQQKGMGQGLFEQYQHLTDQADQILGYSIEKLCTEKSYLDVNHTEYTQPALYVVNALSYLKRVEETGRKPDFAAGHSLGEYNALMAAGAFDFETGLRLVKKRGELMGRITGGGMAAVIGLSKEQVTAVLEEHRLYDIDVANENTPQQIVISGPKKEIEKARAVFENTKDVKLFHPLNVSGAFHSRYMNEAKQVFKQYIDSFQFAPLAIPVISNVYAEPYHQDRLKDTLSEQMDNTVKWTDSIRFLMGRGEMEFAEIGPGTVLTGLIHRIKNEAEPLTYIPKKNPAISAHLKEQRNVQAGITAESLGSAEFKQDYHLTYAYLAGGMYRGIASKEMVVKLSRAGMMGFFGTGGLSLKEVEDAIHAIQGELGKGQAYGINLVHNMKHTESEEKMIDLLLRNQVSIVEASAFLSVTPVLVRYRAKGVKRNQNGDVICSNRLIAKISRPEVAESFLSPAPENMLQKLLGENKITMNEAELLRCIPMADDICVEADSGGHTDGGVAYSLMPAMTSLRDEMMKKYQYRKKIRVGAAGGIGTPEAAMAAFMLGADFILTGSINQCTVEAATSDKVKDLLQQMNVQDTAYAPAGDMFESGSKVQVLKKGVFFPARANKLYELYQRYGSIRELDAKMLAQLEEKYFKRSIEDIYKDIALHYPAADIEKAEQNPKHKMALIFRWYFRYSSKLAISGSEHSKVDYQIHCGPALGAFNQWVKGSQLENWRNRHVDEIGKKLMTETAVLLHERMQSMYQPSHETDNIKIKV
Atome Classification :
(20 SA)
.........10--........20..--.---....-.---30--....---.----------------....40.---.-...----...50---.........60.....--...70......----..80---.-------........90........100.......110....---..---------------------.------120-.---........130---....-...140.-.-----..--...-150.......160.......170.......-----------------180.........190.......200.......--210.--......220..-...-..230--........240........250.....----.-----.260........270-........280-........290.......-300----..-------......310--------.........320.......330.......340.......350.......360-.......370.......380.......390...-....400.......410-........420.....-..430.......440.......450........460.......470.......480.......490.---......-500.....----..510.......520.......530.......540.......550.-----------......560.......570.......580...-....590...--------.-...600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
T
Y
V
FPGQGS--QQKGM
G
Q
G
L
F
E
Q
--
Y
---
Q
H
L
T
-
D
---
Q
---
A
D
Q
I
---
L
----------------
G
Y
S
I
E
K
L
---C-TEK----
S
Y
LD----VNHTEYT
Q
P
A
L
Y
V
V
N
A
--
L
S
Y
L
K
R
V
E
E
TG----RKP----D-------FAAGHSLGE
Y
N
A
L
M
AAGAF
D
F
E
T
G
L
R
L
V
K
K
R
G
E
L
M
---
G
R---------------------I------T---G---G
G
M
A
A
V
IGL
S
K
---
E
Q
V
T
-
A
V
L
E
EHR-
L
-----
Y
D
--
I
DV-ANENTP
Q
Q
I
V
ISG
P
K
K
E
I
E
K
A
R
A
V
F
ENTK
D
-----------------
V
--
K
L
F
HPLNVS
G
A
F
H
S
R
Y
M
N
E
A
K
Q
V
F
K
Q
Y
I
D
--SFQF--AP
L
A
I
P
V
I
S
N
V
-YAE-P
Y
H
-
Q
--
D
R
L
K
D
T
L
S
E
Q
-MDN
T
V
K
W
T
D
S
I
R
F
L
MG----R-----GE-
M
E
F
AEIG
P
G
T
V
--
L
T
G
L
I
H
R
I
KN--EAEP
L
T
YIPKKNP
A
I
S
A
H
-
L
K
-----
E
Q-------RNVQAGI----------
T
A
E
SLG
S
A
E
F
K
Q
DYH
L
T
Y
A
Y
LA
G
G
M
YRGIA
S
K
E
M
V
V
K
L
SRAGM
M
G
F
FGTGGL-
S
L
K
E
V
E
D
A
I
H
A
I
Q
GELGKG
Q
A
Y
G
I
N
L
V
HNMKHT-
E
S
E
E
K
M
I
D
L
L
L
RNQ
V
S
--
I
V
E
A
S
A
F
L
S
V
T
P
V
L
V
R
-
Y
R
A
KGVKRNQNG
D
V
I
CSN
R
L
I
A
K-IS
R
P
E
V
A
E
S
F
LSPA
P
E
N
M
L
Q
K
L
LGENKITM
N
E
A
E
L
L
R
CIPMAD---
D
I
C
V
EA-DSGGHTDG----
G
V
A
Y
S
L
M
P
A
M
T
S
L
R
D
E
M
M
K
K
Y
Q
Y
R
K
K
I
RVGAAGGIG
T
P
E
A
A
M
A
A
F
M
-----------LGA
D
F
I
L
TGSIN
Q
C
T
V
EAA
T
S
D
K
V
K
D
L
L
Q
QMN-VQDTAYAPA
G
--------
D
-MFESGSK
V
Q
V
L
K
KGVFFP
A
R
A
N
K
L
Y
E
L
Y
Q
R
YG
S
I
R
E
L
D
A
K
M
L
A
Q
L
E
E
K
Y
F
K
R
S
I
E
D
I
Y
K
D
I
A
LHYPA
A
D
I
E
K
AEQNPK
H
K
M
A
L
I
F
R
W
Y
F
R
YS
S
K
L
A
ISGSEH
S
K
V
D
Y
Q
I
HCGPA
L
G
A
F
N
Q
WVKGS
Q
L
E
N
W
R
N
R
H
V
D
E
I
G
K
K
L
M
T
E
T
A
V
L
L
H
E
R
M
Q
S
M
YQPSHETD
N
I
K
I
KV
51
HHSearch
78.94
62%
-108
- C1 -
4CW5
1
?
A:
[10-451]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
M
R
L
G
N
E
D
F
K
K
D
Y
N
I
Q
Y
A
Y
M
T
G
S
M
Y
R
G
I
A
S
E
Q
M
V
I
K
A
A
K
A
G
M
L
G
F
F
G
T
G
G
L
-
S
I
E
R
I
G
Q
A
I
G
T
I
R
S
A
L
R
Q
G
E
T
F
G
M
N
L
L
H
H
M
M
S
P
-
D
K
E
V
R
M
I
D
L
Y
L
K
N
G
I
H
--
L
I
E
A
S
A
F
M
G
I
T
P
A
L
V
I
-
Y
R
A
K
G
L
S
R
N
H
D
G
S
V
S
V
Q
N
K
I
I
A
K
-
V
S
R
P
E
V
A
E
A
F
L
N
P
A
P
A
H
V
L
E
R
L
V
S
D
N
R
L
T
A
G
E
A
A
L
A
K
E
I
P
M
A
D
---
D
I
C
V
E
A
-----------------
T
L
M
P
A
M
I
R
L
R
D
R
M
M
E
K
H
G
Y
A
K
K
V
R
I
G
A
A
G
G
I
G
T
P
E
A
A
A
A
A
F
L
-----------
L
G
A
E
F
I
G
T
G
S
I
N
Q
C
T
V
E
A
G
T
S
D
S
V
K
D
L
L
Q
E
A
N
-
V
Q
D
T
S
Y
A
P
A
G
--------
D
-
M
F
E
A
G
A
R
V
Q
V
L
K
K
G
L
F
F
P
A
R
A
N
K
L
F
D
L
Y
R
Q
Y
N
S
L
D
E
I
D
E
K
T
K
T
L
I
E
E
K
Y
F
Q
R
S
F
E
E
V
Y
E
Q
L
K
R
D
K
S
P
E
Q
I
A
K
A
E
Q
N
P
K
H
K
M
A
M
V
F
K
W
Y
F
S
H
T
T
R
L
A
L
E
G
K
S
E
S
K
I
D
Y
Q
I
H
C
G
P
A
L
G
A
F
N
Q
W
V
K
G
T
P
L
E
N
W
R
N
R
H
V
D
L
I
G
K
Q
L
M
E
E
T
A
G
L
L
A
Q
R
L
V
S
---------------
1
PsiBlast_PDB
77.85
59%
-110
- C1 -
4CW5
1
?
A:
[14-452]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
N
E
D
F
K
K
D
Y
N
I
Q
Y
A
Y
M
T
G
S
M
Y
R
G
I
A
S
E
Q
M
V
I
K
A
A
K
A
G
M
L
G
F
F
G
T
G
G
L
-
S
I
E
R
I
G
Q
A
I
G
T
I
R
S
A
L
R
Q
G
E
T
F
G
M
N
L
L
H
H
M
M
S
P
-
D
K
E
V
R
M
I
D
L
Y
L
K
N
G
I
H
--
L
I
E
A
S
A
F
M
G
I
T
P
A
L
V
I
-
Y
R
A
K
G
L
S
R
N
H
D
G
S
V
S
V
Q
N
K
I
I
A
K
-
V
S
R
P
E
V
A
E
A
F
L
N
P
A
P
A
H
V
L
E
R
L
V
S
D
N
R
L
T
A
G
E
A
A
L
A
K
E
I
P
M
A
D
---
D
I
C
V
E
A
-----------------
T
L
M
P
A
M
I
R
L
R
D
R
M
M
E
K
H
G
Y
A
K
K
V
R
I
G
A
A
G
G
I
G
T
P
E
A
A
A
A
A
F
L
-----------
L
G
A
E
F
I
G
T
G
S
I
N
Q
C
T
V
E
A
G
T
S
D
S
V
K
D
L
L
Q
E
A
N
-
V
Q
D
T
S
Y
A
P
A
G
--------
D
-
M
F
E
A
G
A
R
V
Q
V
L
K
K
G
L
F
F
P
A
R
A
N
K
L
F
D
L
Y
R
Q
Y
N
S
L
D
E
I
D
E
K
T
K
T
L
I
E
E
K
Y
F
Q
R
S
F
E
E
V
Y
E
Q
L
K
R
D
K
S
P
E
Q
I
A
K
A
E
Q
N
P
K
H
K
M
A
M
V
F
K
W
Y
F
S
H
T
T
R
L
A
L
E
G
K
S
E
S
K
I
D
Y
Q
I
H
C
G
P
A
L
G
A
F
N
Q
W
V
K
G
T
P
L
E
N
W
R
N
R
H
V
D
L
I
G
K
Q
L
M
E
E
T
A
G
L
L
A
Q
R
L
V
S
I
--------------
4
PsiBlast_PDB
63.05
55%
-107
- C1 -
3SBM
4
?
A:
[1-281]
M
K
A
Y
M
F
P
G
Q
G
S
--
Q
A
K
G
M
G
R
A
L
F
D
A
--
F
---
P
A
L
T
-
A
---
R
---
A
D
G
V
---
L
----------------
G
Y
S
I
R
A
L
---
C
-
Q
D
D
----
P
D
Q
R
----
L
S
Q
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
--
L
S
Y
L
K
R
R
E
E
E
A
-----
P
P
----
D
-------
F
L
A
G
H
S
L
G
E
F
S
A
L
F
A
A
G
V
F
D
F
E
T
G
L
A
L
V
K
K
R
G
E
L
M
---
G
D
---------------------
A
------
R
---
G
---
G
G
M
A
A
V
I
G
L
D
E
---
E
R
V
R
-
E
L
L
D
Q
N
G
-
A
-----
T
A
--
V
D
I
-
A
N
L
N
S
P
S
Q
V
V
I
S
G
A
K
D
E
I
A
R
L
Q
V
P
F
E
-
A
A
G
-----------------
A
--
K
K
Y
T
V
L
R
V
S
A
A
F
H
S
R
F
M
R
P
A
M
V
E
F
G
R
F
L
E
--
G
Y
D
F
--
A
P
P
K
I
P
V
I
S
N
V
-
T
A
R
-
P
C
K
-
A
--
D
G
I
R
A
A
L
S
E
Q
-
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
M
G
----
R
-----
G
V
-
E
E
F
V
E
C
G
H
G
I
V
--
L
T
G
L
Y
A
Q
I
R
R
--
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
61.94
54%
-110
- C1 -
3SBM
4
?
A:
[1-278]
M
K
A
Y
M
F
P
G
Q
G
S
--
Q
A
K
G
M
G
R
A
L
F
D
A
--
F
---
P
A
L
T
-
A
---
R
---
A
D
G
V
---
L
----------------
G
Y
S
I
R
A
L
---
C
-
Q
D
D
----
P
D
Q
R
----
L
S
Q
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
--
L
-
S
Y
L
K
R
R
E
E
E
----
A
P
P
----
D
-------
F
L
A
G
H
S
L
G
E
F
S
A
L
F
A
A
G
V
F
D
F
E
T
G
L
A
L
V
K
K
R
G
E
L
M
---
G
D
---------------------
A
------
R
---
G
---
G
G
M
A
A
V
I
G
L
D
E
---
E
R
V
R
-
E
L
L
D
Q
N
G
-
A
-----
T
A
--
V
D
I
-
A
N
L
N
S
P
S
Q
V
V
I
S
G
A
K
D
E
I
A
R
L
Q
V
P
F
E
-
A
A
G
-----------------
A
--
K
K
Y
T
V
L
R
V
S
A
A
F
H
S
R
F
M
R
P
A
M
V
E
F
G
R
F
L
E
--
G
Y
D
F
--
A
P
P
K
I
P
V
I
S
N
V
-
T
A
R
-
P
C
K
-
A
--
D
G
I
R
A
A
L
S
E
Q
-
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
M
G
----
R
-----
G
V
-
E
E
F
V
E
C
G
H
G
I
V
--
L
T
G
L
Y
A
Q
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
59.63
55%
-107
- C- -
3RGI
-
?
A:
[1-282]
M
K
A
Y
M
F
P
G
Q
G
S
--
Q
A
K
G
M
G
R
A
L
F
D
A
--
F
---
P
A
L
T
-
A
---
R
---
A
D
G
V
---
L
----------------
G
Y
S
I
R
A
L
---
C
-
Q
D
D
----
P
D
Q
R
----
L
S
Q
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
--
L
S
Y
L
K
R
R
E
E
E
A
-----
P
P
----
D
-------
F
L
A
G
H
S
L
G
E
F
S
A
L
F
A
A
G
V
F
D
F
E
T
G
L
A
L
V
K
K
R
G
E
L
M
---
G
D
---------------------
A
------
R
---
G
---
G
G
M
A
A
V
I
G
L
D
E
---
E
R
V
R
-
E
L
L
D
Q
N
G
-
A
-----
T
A
--
V
D
I
-
A
N
L
N
S
P
S
Q
V
V
I
S
G
A
K
D
E
I
A
R
L
Q
V
P
F
E
-
A
A
G
-----------------
A
--
K
K
Y
T
V
L
R
V
S
A
A
F
H
S
R
F
M
R
P
A
M
V
E
F
G
R
F
L
E
--
G
Y
D
F
--
A
P
P
K
I
P
V
I
S
N
V
-
T
A
R
-
P
C
K
-
A
--
D
G
I
R
A
A
L
S
E
Q
-
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
M
G
----
R
-----
G
V
-
E
E
F
V
E
C
G
H
G
I
V
--
L
T
G
L
Y
A
Q
I
R
R
--
D
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
59.45
51%
-105
- C1 -
3G87
-
?
A:
[8-290]
--
T
F
M
F
P
G
Q
G
S
--
Q
A
K
G
M
G
G
A
L
F
D
R
--
F
---
A
D
L
T
-
A
---
Q
---
A
D
A
V
---
L
----------------
G
Y
S
I
R
A
L
---
C
-
V
D
D
----
P
R
D
E
----
L
G
R
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
--
L
T
Y
Y
A
K
C
E
D
S
G
----
E
T
P
----
D
-------
F
L
A
G
H
S
L
G
E
F
N
A
L
L
A
A
G
C
F
D
F
E
T
G
L
K
L
V
A
R
R
A
E
L
M
---
S
Q
---------------------
A
------
R
---
D
---
G
A
M
A
A
I
V
N
A
S
R
---
E
Q
I
E
-
R
T
L
D
E
H
G
-
L
-----
V
D
--
T
A
I
-
A
N
D
N
T
P
S
Q
L
V
I
S
G
P
A
H
E
I
A
R
A
E
A
L
F
Q
H
D
R
------------------
V
--
R
Y
L
R
-
L
N
T
S
G
A
F
H
S
K
F
M
R
P
A
Q
Q
A
F
A
A
H
L
Q
--
S
F
R
L
--
A
D
P
A
I
P
V
I
S
N
V
-
S
A
R
-
P
Y
E
-
N
--
G
R
V
S
E
G
L
A
Q
Q
-
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
L
A
L
A
A
E
R
-----
G
E
A
I
E
F
T
E
L
G
H
G
D
V
--
L
T
R
L
V
H
T
I
R
R
--
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
58.47
42%
-104
* C1 *
3G87
-
?
A:
[6-293]
L
N
T
F
M
F
P
G
Q
G
S
--
Q
A
K
G
M
G
G
A
L
F
D
R
--
F
---
A
D
L
T
-
A
---
Q
---
A
D
A
V
---
L
----------------
G
Y
S
I
R
A
L
---
C
-
V
D
D
----
P
R
D
E
----
L
G
R
T
Q
F
T
Q
P
A
L
Y
V
V
N
A
--
L
T
Y
Y
A
K
C
E
D
S
G
----
E
T
P
----
D
-------
F
L
A
G
H
S
L
G
E
F
N
A
L
L
A
A
G
C
F
D
F
E
T
G
L
K
L
V
A
R
R
A
E
L
M
---
S
Q
---------------------
A
------
R
---
D
---
G
A
M
A
A
I
V
N
A
S
R
---
E
Q
I
E
-
R
T
L
D
E
H
G
-
L
-----
V
D
--
T
A
I
-
A
N
D
N
T
P
S
Q
L
V
I
S
G
P
A
H
E
I
A
R
A
E
A
L
F
Q
-
H
D
------------------
R
--
V
R
Y
L
R
L
N
T
S
G
A
F
H
S
K
F
M
R
P
A
Q
Q
A
F
A
A
H
L
Q
--
S
F
R
L
--
A
D
P
A
I
P
V
I
S
N
V
-
S
A
R
-
P
Y
E
-
N
--
G
R
V
S
E
G
L
A
Q
Q
-
I
A
S
P
V
R
W
C
E
S
I
R
Y
L
L
A
----
L
A
A
E
R
G
E
A
-
I
E
F
T
E
L
G
H
G
D
V
--
L
T
R
L
V
H
T
I
R
R
--
Q
T
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
52.34
37%
-94
- C1 -
3IM9
3
FABD_STAAM
A:
[12-303]
-
M
A
I
I
F
P
G
Q
G
A
--
Q
K
V
G
M
A
Q
D
L
F
N
N
---------
N
-
D
---
Q
---
A
T
E
I
---
L
----------------
T
S
A
A
K
T
L
DFD
I
-
L
E
T
----
M
F
T
D
EEGK
L
G
E
T
E
N
T
Q
P
A
L
L
T
H
S
S
A
L
L
A
A
L
K
N
L
---------
N
P
----
D
-------
F
T
M
G
H
S
L
G
E
Y
S
S
L
V
A
A
D
V
L
S
F
E
D
A
V
K
I
V
R
K
R
G
Q
L
M
---
A
Q
---------------------
A
FP----
T
---
G
V--
G
S
M
A
A
V
L
G
L
D
F
---
D
K
V
D
-
E
I
C
K
S
L
S
-
S
-----
D
D
K
I
I
E
P
-
A
N
I
N
C
P
G
Q
I
V
V
S
G
H
K
A
L
I
D
E
---
L
V
E
K
G
K
S
-----------------
L
GA
K
R
V
M
P
L
A
V
S
G
P
F
H
S
S
L
M
K
V
I
E
E
D
F
S
S
Y
I
N
--
Q
F
E
W
--
R
D
A
K
F
P
V
V
Q
N
V
-
N
A
Q
G
E
T
D
-
K
--
E
V
I
K
S
N
M
V
K
Q
-
L
Y
S
P
V
Q
F
I
N
S
T
E
W
L
I
D
----
Q
-----
G
V
-
D
H
F
I
E
I
G
P
G
K
V
--
L
S
G
L
I
K
K
I
N
R
--
D
V
K
-
L
T
S
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
51.35
18%
-91
- C1 -
2UV8
1
?
G:
[152-865]
-
L
V
A
I
F
G
G
Q
G
N
TD
D
Y
F
E
E
L
R
D
L
Y
Q
T
--
Y
---
H
V
L
V
G
D
---
L
IKF
S
A
E
T
---
L
SELIRTTLDAEKVFTQ
G
L
N
I
L
E
W
---
L
-
E
N
P
SNTP
D
K
D
Y
----
L
L
S
I
P
I
S
C
P
L
I
G
V
I
Q
L
--
A
H
Y
V
V
T
A
K
L
L
G
----
F
T
P
----
G
ELRSYLK
G
A
T
G
H
S
Q
G
L
V
T
A
V
A
I
A
E
T
D
S
W
E
S
F
F
V
S
V
R
K
A
I
T
V
L
---
F
F
IGVRCYEAYPNTSLPPSILED
S
LENNEG
V
---
P
---
S
P
M
L
S
I
S
N
L
T
Q
---
E
Q
V
Q
-
D
Y
V
N
K
T
N
-
S
HLPAG
K
Q
--
V
E
I
-
S
L
V
N
G
A
K
N
L
V
V
S
G
P
P
Q
S
L
Y
G
L
N
L
T
L
R
-
K
A
K
APSGLDQSRIPFSERKL
K
--
F
S
N
R
F
L
P
V
A
S
P
F
H
S
H
L
L
V
P
A
S
D
L
I
N
K
D
L
V
KN
N
V
S
F
NA
K
D
I
Q
I
P
V
Y
D
T
F
-
D
G
S
-
D
L
R
-
V
LS
G
S
I
S
E
R
I
V
D
C
I
I
R
L
P
V
K
W
E
T
T
T
Q
F
-------------
K
A
-
T
H
I
L
D
F
G
P
G
G
A
SG
L
G
V
L
T
H
R
N
K
D
--
G
T
G
V
R
V
I
V
A
G
T
L
D
I
N
P
D
D
D
Y
G
FKQEI
F
D
VTSNGLK
K
N
P
N
W
L
E
EYHPKLIKNK
S
G
K
I
F
V
E
T
K
F
S
K
L
I
G
R
P
-
P
L
L
V
P
G
M
T
P
C
T
V
S
P
D
F
V
A
A
T
T
N
A
G
Y
T
I
E
L
A
G
G
G
Y
F
S
A
A
G
M
T
A
A
I
D
S
V
V
S
Q
I
E
K
G
S
T
F
G
I
N
L
I
Y
V
N
P
F
M
L
Q
W
G
I
P
L
I
K
E
L
R
S
K
G
Y
P
IQ
F
L
T
I
G
A
G
V
P
S
L
E
V
A
S
E
Y
I
E
T
L
G
L
K
------------
Y
L
G
L
K
P
G
S
I
D
A
I
S
Q
V
I
N
I
A
-----------------------
K
-
A
H
P
N
FPI
A
L
Q
W
T
G
G
R
G
G
G
H
H
S
F
EDAH
T
P
M
L
Q
M
Y
S
K
I
R
R
-----------
H
P
N
I
M
L
I
F
G
S
G
F
G
S
A
D
D
T
Y
P
Y
L
T
GEWSTKFDYPP
M
P
F
D
G
F
L
F
G
S
R
V
M
I
A
K
E
V
K
T
S
P
D
A
K
K
C
I
A
A
C
T
G
V
P
D
D
K
W
E
Q
T
Y
KKPTGGIV
T
V
R
S
E
M
G
E
P
I
H
K
I
A
T
---------
R
G
V
M
L
W
K
E
F
D
-------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
50.60
34%
-93
- C1 -
3K89
1
?
A:
[6-300]
-
L
A
F
V
F
P
G
Q
G
S
--
Q
S
L
G
M
L
A
E
L
S
E
L
--
H
---
P
Q
I
R
-
E
T
F
A
E
---
A
S
E
G
---
A
----------------
G
V
D
L
W
A
L
---
S
-
Q
G
G
----
P
E
E
M
----
L
N
R
T
E
Y
T
Q
P
A
L
L
A
A
G
V
--
A
V
W
R
L
W
T
A
Q
R
G
----
Q
R
P
----
A
-------
L
L
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
---
Q
A
---------------------
A
------
A
---
P
AGV
G
A
M
A
A
V
L
G
A
E
D
---
A
V
V
L
-
E
V
C
A
E
A
A
-
G
-----
S
Q
--
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
-
R
G
-----------------
V
--
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
--
G
L
S
W
--
H
A
P
Q
I
P
V
V
Q
N
V
-
D
A
R
-
V
H
D
G
S
--
A
A
I
R
Q
A
L
V
E
Q
-
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
----
Q
-----
G
I
-
T
R
I
A
E
C
G
P
G
K
V
--
L
S
G
L
I
K
R
I
D
K
SL
D
A
R
P
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
50.56
34%
-97
- C1 -
3R97
1
?
A:
[6-300]
-
L
A
F
V
F
P
G
Q
G
S
--
Q
S
L
G
M
L
A
E
L
S
E
L
--
H
---
P
Q
I
R
-
E
T
F
A
E
---
A
S
E
G
---
A
----------------
G
V
D
L
W
A
L
---
S
-
Q
G
G
----
P
E
E
M
----
L
N
R
T
E
Y
T
Q
P
A
L
L
A
A
G
V
--
A
V
W
R
L
W
T
A
Q
R
G
----
Q
R
P
----
A
-------
L
L
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
V
L
S
L
H
D
G
A
H
L
V
R
L
R
G
Q
F
M
---
Q
A
---------------------
A
------
A
---
P
AGV
G
A
M
A
A
V
L
G
A
E
D
---
A
V
V
L
-
E
V
C
A
E
A
A
-
G
-----
S
Q
--
V
V
V
P
A
N
F
N
S
P
G
Q
I
V
I
G
G
D
A
A
A
V
D
R
A
L
A
L
L
A
E
-
R
G
-----------------
V
--
R
K
A
V
K
L
A
V
S
V
P
S
H
T
P
L
M
R
D
A
A
N
Q
L
G
E
A
M
A
--
G
L
S
W
--
H
A
P
Q
I
P
V
V
Q
N
V
-
D
A
R
-
V
H
D
G
S
--
A
A
I
R
Q
A
L
V
E
Q
-
L
Y
L
P
V
Q
W
T
G
C
V
Q
A
L
A
S
----
Q
-----
G
I
-
T
R
I
A
E
C
G
P
G
K
V
--
L
S
G
L
I
K
R
I
D
K
SL
D
A
R
P
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
49.46
34%
-91
- C1 -
3PTW
-
?
A:
[3-288]
K
L
G
F
L
F
A
G
Q
G
A
--
Q
Y
V
G
M
G
K
E
F
F
D
N
--
F
---
E
E
S
K
-
E
---
V
---
F
K
R
S
S
E
A
L
----------------
G
I
D
M
E
E
L
---
C
-
F
N
D
----
P
E
G
L
----
L
N
K
T
E
F
T
Q
P
A
I
I
T
T
N
M
--
A
I
-
L
T
A
L
D
K
L
G
----
V
K
S
----
H
-------
I
S
C
G
L
S
L
G
E
Y
S
A
L
I
H
S
G
A
I
N
F
E
D
G
V
K
L
V
K
K
R
G
K
F
M
---
Q
E
---------------------
A
------
V
AEG
I
---
G
G
M
V
A
V
L
R
M
T
P
---
E
Q
V
D
-
E
I
I
E
K
S
S
P
Y
-----
G
I
--
V
E
G
-
A
N
Y
N
S
P
G
Q
I
V
I
S
G
E
L
V
A
L
E
K
A
M
E
F
I
K
-
E
V
G
--------------------
G
R
A
I
K
L
P
V
S
A
P
F
H
C
S
M
L
Q
P
A
A
E
K
L
E
D
E
L
N
--
K
I
S
I
--
N
K
L
N
G
I
V
M
S
N
V
-
K
G
E
-
A
Y
L
-
E
D-
D
N
I
I
E
L
L
T
S
Q
-
V
K
K
P
V
L
F
I
N
D
I
E
K
M
I
E
----
S
-----
G
V
-
D
T
F
I
E
I
G
P
G
K
A
--
L
S
G
F
V
K
K
I
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
49.16
35%
-99
- C1 -
3QAT
2
?
A:
[7-297]
-
A
A
F
T
F
P
G
Q
G
S
--
Q
L
I
G
M
G
K
V
L
T
E
Q
--
F
---
V
A
A
R
-
M
---
V
---
F
E
E
V
D
D
A
L
----------------
S
E
K
L
S
D
I
---
I
-
F
E
G
----
P
A
D
V
----
L
T
L
T
A
N
A
Q
P
A
L
M
A
V
S
M
--
A
V
-
I
R
V
M
E
Q
L
G
----
L
N
V
EKKV
K
-------
F
V
A
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
---
Q
A
---------------------
A
------
V
AVG
E
---
G
S
M
A
A
L
I
G
L
D
E
---
K
D
V
E
-
E
I
C
E
I
V
A
E
E
-----
G
L
--
C
Q
I
-
A
N
D
N
G
G
G
Q
I
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
A
S
-
Q
K
G
-----------------
A
--
K
R
A
V
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
--
T
V
N
K
--
T
A
P
I
V
P
L
I
A
N
V
-
S
V
I
-
P
E
S
-
D
P
-
E
R
I
V
S
L
L
V
Q
Q
-
V
T
G
R
V
R
W
R
E
T
I
E
W
I
S
A
----
N
-----
G
V
-
N
T
L
F
E
I
G
S
G
K
V
--
L
T
G
L
A
R
R
I
N
K
--
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
48.88
35%
-105
- C1 -
3IM8
1
?
A:
[6-289]
---
F
L
F
A
G
Q
G
A
--
Q
Y
L
G
M
G
R
D
F
Y
D
Q
--
Y
P
I
V
K
E
T
I
-
D
---
R
---
A
S
Q
V
---
L
----------------
G
Y
D
L
R
Y
L
---
I
D
T
E
E
----
D
K
L
------
N
Q
T
R
Y
T
Q
P
A
I
L
A
T
S
V
--
A
I
Y
-
R
L
L
Q
E
K
G
----
Y
Q
P
----
D
-------
M
V
A
G
L
S
L
G
E
Y
S
A
L
V
A
S
G
A
L
D
F
E
D
A
V
A
L
V
A
K
R
G
A
Y
M
E
E
A
A
P
---------------------
A
------
D
---
S
---
G
K
M
V
A
V
L
N
T
P
V
---
E
V
I
E
E
A
C
Q
K
A
S
E
-
L
-----
G
V
--
V
T
P
-
A
N
Y
N
T
P
A
Q
I
V
I
A
G
E
V
V
A
V
D
R
A
V
E
L
L
Q
E
A
G
A
-----------------
K
--
R
L
I
-
P
L
K
V
S
G
P
F
H
T
S
L
L
E
P
A
S
Q
K
L
A
E
T
L
A
--
Q
V
S
F
--
S
D
F
T
C
P
L
V
G
N
T
-
E
A
A
-
V
M
Q
-
K
--
E
D
I
A
Q
L
L
T
R
Q
-
V
K
E
P
V
R
F
Y
E
S
I
G
V
M
Q
E
----
A
-----
G
I
-
S
N
F
I
E
I
G
P
G
K
V
--
L
S
G
F
V
K
K
I
D
Q
--
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
48.71
35%
-97
- C1 -
3QAT
2
?
B:
[9-303]
---
F
T
F
P
G
Q
G
S
--
Q
L
I
G
M
G
K
V
L
T
E
Q
--
F
V
A
A
R
M
V
F
-
E
---
E
---
V
D
D
A
---
L
----------------
S
E
K
L
S
D
I
---
I
-
F
E
G
----
P
A
D
V
----
L
T
L
T
A
N
A
Q
P
A
L
M
A
V
S
---
M
A
V
I
R
V
M
E
Q
L
G
LNVE
K
K
V
----
K
-------
F
V
A
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
---
Q
A
---------------------
A
------
V
---
A
VGE
G
S
M
A
A
L
I
G
L
D
E
K
D
V
E
E
I
C
-
E
I
V
A
E
E
G
-
L
-----
C
Q
--
I
---
A
N
D
N
G
G
G
Q
I
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
-
A
S
Q
K
G
-----------------
A
--
K
R
A
V
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
--
T
V
N
K
--
T
A
P
I
V
P
L
I
A
N
V
-
S
V
I
-
P
E
S
-
D
P
-
E
R
I
V
S
L
L
V
Q
Q
-
V
T
G
R
V
R
W
R
E
T
I
E
W
I
S
A
----
N
-----
G
V
-
N
T
L
F
E
I
G
S
G
K
V
--
L
T
G
L
A
R
R
I
N
K
--
D
I
K
A
L
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
48.38
35%
-94
- C1 -
3QAT
2
?
A:
[9-303]
---
F
T
F
P
G
Q
G
S
--
Q
L
I
G
M
G
K
V
L
T
E
Q
--
F
V
A
A
R
M
V
F
-
E
---
E
---
V
D
D
A
---
L
----------------
S
E
K
L
S
D
I
---
I
-
F
E
G
----
P
A
D
V
----
L
T
L
T
A
N
A
Q
P
A
L
M
A
V
S
---
M
A
V
I
R
V
M
E
Q
L
G
LNVE
K
K
V
----
K
-------
F
V
A
G
H
S
L
G
E
Y
S
A
L
C
A
A
G
T
F
S
L
T
D
T
A
R
L
L
R
I
R
G
N
A
M
---
Q
A
---------------------
A
------
V
---
A
VGE
G
S
M
A
A
L
I
G
L
D
E
K
D
V
E
E
I
C
-
E
I
V
A
E
E
G
-
L
-----
C
Q
--
I
---
A
N
D
N
G
G
G
Q
I
V
I
S
G
E
A
K
A
V
E
T
A
V
E
V
-
A
S
Q
K
G
-----------------
A
--
K
R
A
V
L
L
P
V
S
A
P
F
H
S
A
L
M
Q
P
A
A
N
A
M
K
N
A
L
L
--
T
V
N
K
--
T
A
P
I
V
P
L
I
A
N
V
-
S
V
I
-
P
E
S
-
D
P
-
E
R
I
V
S
L
L
V
Q
Q
-
V
T
G
R
V
R
W
R
E
T
I
E
W
I
S
A
----
N
-----
G
V
-
N
T
L
F
E
I
G
S
G
K
V
--
L
T
G
L
A
R
R
I
N
K
--
D
I
K
A
L
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
48.01
34%
-94
- C1 -
2G1H
1
FABD_ECOLI
A:
[5-287]
---
F
V
F
P
G
Q
G
S
--
Q
T
V
G
M
L
A
D
M
A
A
S
--
Y
---
P
I
V
E
-
E
T
F
A
E
---
A
S
A
A
---
L
----------------
G
Y
D
L
W
A
L
---
T
-
Q
Q
G
----
P
A
E
E
----
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
--
A
L
Y
R
V
W
Q
Q
Q
G
G
----
K
A
P
----
A
-------
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
---
Q
E
---------------------
A
------
V
PEG
T
---
G
A
M
A
A
I
I
G
L
D
D
---
A
S
I
A
-
K
A
C
E
E
A
A
-
E
-----
G
Q
V
-
V
S
P
-
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
-----------------
K
--
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
--
K
I
T
F
--
N
A
P
T
V
P
V
V
N
N
V
-
D
V
K
C
E
T
N
-
G
--
D
A
I
R
D
A
L
V
R
Q
-
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
----
Q
-----
G
V
-
E
H
L
Y
E
V
G
P
G
K
V
--
L
T
G
L
T
K
R
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
47.84
34%
-93
- C1 -
2G2Y
1
FABD_ECOLI
A:
[5-287]
---
F
V
F
P
G
Q
G
S
--
Q
T
V
G
M
L
A
D
M
A
A
S
--
Y
---
P
I
V
E
-
E
T
F
A
E
---
A
S
A
A
---
L
----------------
G
Y
D
L
W
A
L
---
T
-
Q
Q
G
----
P
A
E
E
----
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
--
A
L
Y
R
V
W
Q
Q
Q
G
G
----
K
A
P
----
A
-------
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
---
Q
E
---------------------
A
------
V
PEG
T
---
G
A
M
A
A
I
I
G
L
D
D
---
A
S
I
A
-
K
A
C
E
E
A
A
-
E
-----
G
Q
V
-
V
S
P
-
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
-----------------
K
--
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
--
K
I
T
F
--
N
A
P
T
V
P
V
V
N
N
V
-
D
V
K
C
E
T
N
-
G
--
D
A
I
R
D
A
L
V
R
Q
-
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
----
Q
-----
G
V
-
E
H
L
Y
E
V
G
P
G
K
V
--
L
T
G
L
T
K
R
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
47.66
35%
-107
- C- -
3EZO
-
?
A:
[3-285]
--
A
F
V
F
P
G
Q
G
S
--
Q
S
V
G
M
L
N
A
F
A
D
V
A
V
V
---
R
E
T
L
-
D
---
E
---
A
S
D
A
---
L
----------------
G
Q
D
I
G
K
L
---
I
-
A
D
G
----
P
A
D
E
----
L
N
L
T
T
N
T
Q
P
V
M
L
T
A
A
Y
--
A
C
Y
R
A
W
Q
Q
A
G
G
----
A
Q
P
----
S
-------
I
V
A
G
H
S
L
G
E
Y
T
A
L
V
A
A
G
A
I
A
F
R
D
A
L
P
L
V
R
F
R
A
Q
A
M
---
Q
T
AVP------------------
V
------
G
---
V
---
G
G
M
A
A
I
L
G
L
D
D
---
D
T
V
R
-
A
V
C
A
E
A
S
-
A
-----
T
G
V-
V
E
A
-
V
N
F
N
A
P
A
Q
V
V
I
A
G
T
K
A
G
I
E
K
A
C
E
I
A
K
E
-
K
G
-----------------
A
--
K
R
A
L
P
L
P
V
S
A
P
F
H
S
S
L
L
K
P
A
S
D
K
L
R
E
Y
L
A
--
G
V
D
V
--
K
A
P
K
I
S
V
V
N
N
I
D
V
A
V
-
V
S
D
-
P
--
A
A
I
K
D
A
L
V
R
Q
-
A
A
G
P
V
R
W
V
E
C
V
Q
H
I
A
R
----
E
-----
G
V
-
T
H
V
I
E
C
G
P
G
K
V
--
L
A
G
L
T
K
R
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
47.34
34%
-94
- C1 -
2G2Z
2
FABD_ECOLI
A:
[5-287]
---
F
V
F
P
G
Q
G
S
--
Q
T
V
G
M
L
A
D
M
A
A
S
--
Y
---
P
I
V
E
-
E
T
F
A
E
---
A
S
A
A
---
L
----------------
G
Y
D
L
W
A
L
---
T
-
Q
Q
G
----
P
A
E
E
----
L
N
K
T
W
Q
T
Q
P
A
L
L
T
A
S
V
--
A
L
Y
R
V
W
Q
Q
Q
G
G
----
K
A
P
----
A
-------
M
M
A
G
H
S
L
G
E
Y
S
A
L
V
C
A
G
V
I
D
F
A
D
A
V
R
L
V
E
M
R
G
K
F
M
---
Q
E
---------------------
A
------
V
PEG
T
---
G
A
M
A
A
I
I
G
L
D
D
---
A
S
I
A
-
K
A
C
E
E
A
A
-
E
-----
G
Q
V-
V
S
P
-
V
N
F
N
S
P
G
Q
V
V
I
A
G
H
K
E
A
V
E
R
A
G
A
A
C
K
A
A
G
A
-----------------
K
--
R
A
L
-
P
L
P
V
S
V
P
S
H
C
A
L
M
K
P
A
A
D
K
L
A
V
E
L
A
--
K
I
T
F
--
N
A
P
T
V
P
V
V
N
N
V
-
D
V
K
C
E
T
N
-
G
--
D
A
I
R
D
A
L
V
R
Q
-
L
Y
N
P
V
Q
W
T
K
S
V
E
Y
M
A
A
----
Q
-----
G
V
-
E
H
L
Y
E
V
G
P
G
K
V
--
L
T
G
L
T
K
R
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------