@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17190: (2016-06-27 )
MRWRSNVKKITKQLTLSLKNPFIYHHVVYGQNVLPGLAYIDIIYQIFREHGFSCSELQLRNLSIYQPLTAEQDAVIVLNIQCAEKKEGQWQITAKGIEKRDGKEASEEKLYMKADMHADSPAIFEETLDLSQIKASAQNVVQLDDVYEQCRRQELVHSEYMKAKGCIYEEEDGVLLELSLGSEAMLHAEGFMFHPTLIDGSGVGANHLLTSLLKGEQRLYLPLFYESFSASALLQTDCMTRIKRSSVRREKELIYVTLEFFNASGEKVAELKNFTSKLVREAELISGKHQDAQETQMTRADTAERDKPADMVSSPVNSYSEAEQFVSQLIAEKINKPVEQVEKQVGYYQMGLNSSGLLEVVETISDKIGESLSPTLLFEHTTIAELSAFLAEEYAEHFSAAGSLGQNERARVSDSINDHKTVEGSRPAPIEAAGDIAIIGLAGRYPKAANIHEFWNNLKEGKDCVSEIPESRWDWQRLEGITSPSGKDISKWGGFIDDPDCFDPQFFRITPREAETMDPQERLFLETCWETIEDAGYTPKTLAKPKGRNKRQHVGVFAGVMHKDYTLVGAEEASAENVFPLSLNYAQIANRVSYFCNFHGPSMAVDTVCSSSLTAVHLALESIRHGECDVALAGGVNLSLHPNKYMTYGVWDMFSTDGHCRTFGKDGDGYVPAEGIGAVLLKPLRQAEEDGDRIYAVIKGSAVNHVGTVSGISVPSPVSQADLIETCLEKTGIDPRTISYVEAHGTGTSLGDPIEIQGLVKAFRQYTQDRQFCSIGSVKSNIGHAESAAGISGLSKVALQLHHQKLVPSLHSEELNPYVDFEKSPFYVQHETETWKQPVIKENGEDVPYPRRAGISSFGATGSNAHIILEEHIPQAAEQDVSLSSDSDISAVIPLSARNQERLRVYAKRLLDFLHDGIQIRDLAYTLQVGREPMEERVSFLASGIQELSDQLKAFIEGRKAIQHCWKGRVSRGSEPSRPAESVHKLLEQRKLDQIAEQWANGSGVDWKLLYEGSKPKRISLPTYPFERVRYWVPKAEKKTDRSKQERHILHPLLHQNVSDISGVRFRSAFTGREFFLKDHVIKGEHVLPGAALLEMVRAAVERAAADQFPTGFRLRNIVWVRPFAVTEQQKDIDVRLYPEENGEITFEICRDPESAEESPIVYGQGSAVLCEAGENPVINIEELKASYNGRTLSPFDCYEAYTEMGIHYGDSHRAIDSLYAGENGVLVKLTMPPVISDTEDHYILHPSMIDSAFQASIGLRLGGATSLEDRKAMLPFAIQDVRIFKGCEASMWARITYSEGSTAGDRMQKLDIDLCNEEGQVCVRLTSYSARVLETDQEGPSEANDTLLFEHIWEERAAERQELIEYDTYKVVVCDVGEQMESLQNHLDCTVLQHDTETIDERFEGYAIQLFEEIKQLMHSKTGGHTFIQVAVPALDEPQLLSGLTGLLKTAELENPKLTGQLIEIETGMSAGELFEILEENRRYPRDTHIRHWQGKRFVSKWKEVSGEHLSADMPWKDKGVYLITGGAGGLGFIFATEIANQTNDAVVILTGRSPLDERKKKKLKALQKLGIQAIYRQADLADKQTVDALLKETQNVYGDLDGIIHSAGLIKDNFIMKKKKEEVQTVLAPKVAGLIHLDEATKDIPLDFFILFSSGAGAVGSAGQADYAMANAFMNAFSEYRNGQAELHKRYGKTLSVCWPLWKDGGMQIDAETARMLKRETGMVAMETDRGIQALYHGWTSGKPQVLVASGVTDRIRAFLHETGHGKGQSHNIKKSSLNQEAEKADMIGEIDEEILREKAENYFKQVLSSVIKLPAGQIDAEAPLEDYGIDSIMIMHVTGQLEKVFGSLSKTLFFEYQDIRSLTRYFIDSRREKLLDILGFETGKPSVERKSEPEKQEIPVIPRKSGFLPLQDKEQKQVREKETEEIAIIGISGRYPQADNIDELWEKLRDGRDCITEIPADRWDHSLYYDEDKDKPGKTYSKWGGFMKDVDKFDPQFFHISPREAKLMDPQERLFLQCVYETMEDAGYTREHLGRKRDAELGGSVGVYVGVMYEEYQLYGAQEQVRGRSLALTGNPSSIANRVSYYFDFHGPSIALDTMCSSSLTAIHLACQSLQRGECEAAFAGGVNVSIHPNKYLMLGQNKFMSSKGRCESFGQGGDGYVPGEGVGAVLLKPLSKAVEDGDHIYGIIKGTAINHGGKTNGYSVPNPNAQADVIKKAFVEAKVDPRTVSYIEAHGTGTSLGDPIEITGLSKVFTQETDDKQFCAIGSAKSNIGHCESAAGIAGVTKVLLQMKYRQLAPSLHSNVLNPNIDFLNSPFKVQQELEEWKRPIISVNGKDIELPRIAGVSSFGAGGVNAHILIEEYAPEPVEERLPARKQPAVIVLSAKNEERLQKRAERLLHAIREQTYVEADLHRIAYTLQVGREAMKERLAFVAETMQELEEKLYECISGTENREYVYRGQVKSNKEAIAAFAADEDMSKTIEAWLQKGKYAKVLDLWVRGLRIDWSTLYQDQKPRRISLPAYPFARDRYWIDVNAKAEEKRTEEPFAPVQPVIPKPSVDREASGKPANITLQPLMTNQDRLERVPSDTETETITAEALCDELTAGLAEVLYMDQNEIDPDEAFIDIGMDSITGLEWIKAINKQYGTSLNVTKVYDYPTTRDFAVYLAHELSTQAGEKKQTETYTPIRQKTVVPAAKPANISLQPLEHHQPVQEEAEETIQYAAAEISASRQYTVAIETLHENLRESIADVLYMEPYEVDIDEAFIDIGMDSITGLEWIKAVNKQYGTSFTVTRVYDYPTIRDFAEMLKSELGTHLDRKIEHTDSFEAAQQKPAASSHPKPAERPLQPVQHPIKKEHEKKTVPVLQDRPEDAIAIVGMSGRYPGARNVREYWDNLVHARNAIRDIPTSRWDVDKYYDPVLNKKGKVYCKSMGMLDDIEHFDPLFFNIPPSEAELMDPQHRIFLQEGYKAFEDAGYNARTLNEKKCGVYLGIMSNEYGVMLNRQSRANATGNSFAIAAARIPYFLNLKGPAIPIDTACSSSLVGTHLARQALINKEIDMALVGGVSLYLTPESYMSMCEAGMLSPDGQCKAFDNGANGFVPGEGAGALVLKRLKDAEADRDHIYGIIIGSGINQDGKTNGITAPSAKSQMDLERDIYETYGIHPESISYVEMHGTGTKQGDPIELEALSTVFQEKTDKKQFCAIGSVKSNIGHTSAAAGVAGVQKVLLCMNHKTLVPTLNFTTPNEHFEFEHSPLYVNTELKPWETADGKPRRACVSSFGYSGTNAHIVIEEYQPEKRNDRLTKQHRSALFVLSAKKEKQLKAYAEAMKDFVTSNEDIDLEDMAYTLQTGREAMDYRMAFLADSREMLIKALDDYLAEMPNGSIFAAHVKTKKSEIKLFETDHDAKALLQTWIEKKRLEKVAELWVKGLQIDWNKLYGEYTPRRISLPAYPFAEEYYWLPTQEGEPETIATAMPQFELMPKRCFLRKQWQPCPIEPAEMTNQTVAILANEETMALAEELSAYFSTYRIFDSQELDRVSAADYEHVAGAIDLIGCGTSHEHSMGWINWLQKLIEQGRASKHHLTVLGVTKGLEAYANEGVLLSGASRAGLYRMLQSEYSHLTSRHADMECEASHEELARLIAVEYYAKSTESEVCYRNGQRYRAYLTEQPAEAALSHKQVSFSTDKVLLITGGTRGLGLLCARHFVKTYGVKRLVLIGREELPPRDQWNSVKISSLAEKIKAVQELEDMGAQVQVLSLDLTDRVAVEQSLKTIHETMGAIGGVIHCAGMVNKQNPAFIRKSLEEIGQVLEPKVEGLQTLFDLLQDEPLAFFTLFSSVSAAIPALAAGQADYAMANAFMDYFAEAHQDKCPIVSIQWPNWKETGLGEVRSKALEQTGLISLTNDEGLQLLDQILSDRQYAVVLPAVPDTNVWKPDKLMQPSLPVEALSHPETKEQTSTRNLFPETVDWLVTLFSDELKIAAEDFETDEPFQEYGIDSIILAQLVQQMNQQLNGDIDPSILFEYPTIESFAHWLISKYDISAVLQPSVPEKQTPLKPQSAMKQKLVPEQRPQQISHEKTALLAEDIAIIGLSCRFPGAETLEEYWDLIRDGRSAIAPVPPERFGNSSSNYAGLIDEMNRFDHDFFMMSESDVRAMDPQALAVLEESLKLWYHAGYTEKEVKGMRAGVYIGGRSQHKPDPASLSKAKNPIVAGGQNYLAANISQFFDLKGPSIVLDTACSSALVGLNMAIQALRSGDIEAAVVGGVSLLDADAHRMFHERGLLCDKPSFHIFDKRADGVILGEGVGMVLVKTVNQAVEDGDSIYAVIKAAAINNDGRTAGPSSPNLEAQKDVMLSALEKSGKKTEEISYLEANGSGSAVTDLLELKAIQSIYRSESKAPLGLGSVKPNIGHPLCAEGIASLIKVALMLKHRQLVPFLSGNENMPYFDIEKTDLYFSRSQAEWKETTPAAAINCFADGGTNAHLIIEGWRDSAERPIRRKPLPLPELNRQPVLIKPSAQNVQKKVHSDTGASKDMFWKTFK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.-.......490.......500.......510.......520.......530.......540.....---..550.......560.......570.-----.....-.580.......590.......600.......610.......620.......630.......640.......650.....-..660.......670.......680.......690.......700.....-.-.710.......720.......730.......740.......750.......760......--.770.......780.......790.......800.......810.......820........830.......840.......850.......860.......870.......880.......890.......900.......910....----...920.......930.......940.......950------------------------------------------------------.-----------------------------...------..----..960------------.------------------------------.---------..--------....----------------------970..-----------------------.-----------------------------------..-------...980...------------------...---------------------.990.......1000-......1010-.-----.....1020......1030......1040--......1050......1060.......1070........1080..--....1090......1100.....-.1110......1120......1130......1140......1150......1160......1170...--...1180.......---..1190......1200......1210......1220......1230.....-.1240......---1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040.....---....2050......2060........2070...-....2080......2090......2100......2110......2120......2130......2140......-2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260--..-----.....2270......2280......2290......2300......2310......2320......2330......2340.......2350......2360......2370....-..2380......2390......2400......2410......2420......2430......2440......2450----......2460......2470......2480......2490......2500......2510..-....2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630........2640...-....2650......2660......2670---------.........2680......2690......2700.....-.2710......2720......2730......2740......2750......2760......2770......2780......2790......2800......2810......2820......2830......2840......2850......2860......2870......2880...-...2890......2900......2910.......2920......2930......2940......2950......2960......2970......2980......2990......3000......3010......3020......3030......3040......3050......3060......3070......3080......3090......3100......3110......3120......3130......3140......3150......3160......3170......3180......3190......3200......3210......3220......3230......3240......3250......3260......3270......3280......3290......3300......3310......3320......3330......3340......3350......3360......3370......3380......3390......3400-----........3410...-...3420......3430......3440......3450......3460......3470......3480......3490......3500......3510......3520......3530.......3540......3550......3560......3570......3580......3590.........3600......3610......3620......3630......3640......3650......3660......3670......3680......3690------.......3700......3710......3720......3730......3740......3750......3760......3770......3780......3790......3800......3810......3820......3830......3840......3850......3860......3870......3880......3890......3900......3910......3920......3930......3940......3950......3960......3970......3980......3990......4000......4010......4020......4030......4040......4050......4060......4070......4080......4090......4100......4110......4120......4130......4140......4150......4160......4170......4180......4190......4200......4210......4220......4230......4240......4250......4260......4270......4280......4290......4300......4310......4320......4330......4340......4350......4360......4370......4380......4390......4400......4410......4420......4430......4440......4450......4460......4470......4480......4490......4500......4510......4520......4530.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
W
R
S
N
V
K
K
I
T
K
Q
L
T
L
SLKN
P
F
I
Y
H
H
V
VYGQNVLP
G
L
A
Y
I
D
I
I
Y
Q
I
F
R
E
HGFSCS
E
L
Q
L
RN
L
S
I
YQPLTAEQ
D
A
V
I
V
L
N
I
Q
CAEKKEG
Q
W
Q
I
T
AKGIEKRDGKEASEE
K
L
Y
M
K
ADMHADS
P
A
I
F
E
E
TL
D
L
S
Q
I
K
A
S
A
Q
N
V
V
Q
L
D
D
V
Y
E
Q
C
R
R
Q
E
L
V
H
S
E
Y
M
K
AKG
C
I
Y
EEED
G
V
L
L
E
L
SLGS
E
A
M
L
HAE
G
F
M
F
H
P
T
LIDGSGV
G
A
N
H
L
L
T
S
L
LKGE
Q
R
L
Y
L
P
L
F
YESFS
A
S
A
L
L
Q
T
D
C
M
T
R
I
K
R
S
S
VRRE
K
E
L
I
Y
V
T
L
E
F
FNASG
E
K
V
A
E
L
K
N
F
T
S
K
L
V
R
E
A
E
L
ISGKHQ
D
A
Q
E
T
Q
MTRADTAERDK
P
A
D
M
V
S
S
P
V
N
S
Y
S
E
A
E
Q
F
V
S
Q
L
I
A
E
K
IN
K
P
V
E
Q
V
E
K
QVG
Y
Y
QMGLN
S
S
G
L
L
E
V
V
E
T
I
S
D
K
IGESLS
P
T
L
L
F
EHT
T
I
A
E
L
S
A
F
L
A
E
E
Y
A
E
H
F
S
A
AGSLGQN
E
R
ARVSDSINDHKTVEGSRPAPIEAAG
D
I
A
I
I
GLAGRYPKAA
N
I
H
E
F
W
N
N
L
K
E
G
K
D
C
V
S
EIPESRW
D
W
Q
R
L
EGI-T-SPSGK
D
I
S
K
WGGFIDDPDCFDP
Q
F
F
R
ITPREAETM
D
P
Q
E
R
L
F
L
E
T
C
W
E
T
I
E
DAGYTPKTLAKPKG---RNK
R
Q
H
V
G
V
F
A
G
V
MHK
D
Y
T
L
VGAEEA-----SAE
N
V
-
F
P
LSL
N
Y
A
Q
I
A
N
R
V
S
Y
F
C
NFHGP
S
M
A
V
D
T
V
CSS
S
L
T
A
V
H
L
A
L
E
S
IRHGEC
D
V
A
L
AG
G
V
N
L
S
LHPNK
Y
M
T
Y
G
V
W
DMFSTD-GHCRTFGKDGDGYVP
A
E
G
I
G
A
V
L
L
K
P
L
R
Q
AEEDG
D
R
I
Y
A
V
I
KGSAVN
H
V
G
-T-VSGISVPSPV
S
Q
A
D
L
I
E
T
C
L
E
KTGIDPR
T
I
S
Y
V
E
AHGTGTSLGD
P
I
E
I
Q
G
L
V
K
A
F
R
Q
Y
TQ--DRQFCSIGS
V
K
SNIGHA
E
S
A
A
G
I
S
G
L
S
K
V
A
L
Q
L
H
H
Q
K
L
V
P
S
L
H
S
EELNPYVD-FEKS
P
F
Y
V
QHETETWKQP
V
I
KENGEDVPYPRRAGISSFGATGS
N
A
H
I
I
L
E
E
HIP
Q
A
A
E
QDVSLSSDSD
I
S
A
V
IPLSAR
N
Q
E
R
L
R
V
Y
A
K
R
L
L
D
F
L
HD----G
I
Q
I
R
D
L
A
Y
T
L
Q
VGRE
P
M
E
E
R
V
S
F
L
A
S
G
I
Q
E
L
S
D
Q
-------------------------------------------------------
L
-----------------------------
K
A
F
------
I
E
----
G
R
K
A
-------------
I
------------------------------
Q
---------
H
C
--------WKGR----------------------VS-RG-----------------------S-----------------------------------EP-------SR
P
A
E
S
V
H
K
------------------
L
L
E
---------------------
Q
R
K
L
D
Q
I
A
E
Q
WANGS-GV
D
W
K
L
L
YEG-S-----K
P
K
R
ISLPTY
P
F
E
R
V
R
Y
WVPKAEKKT
D
R
S
--
K
Q
E
R
H
I
L
H
P
L
L
HQN
V
S
DI-S
G
V
R
F
R
S
AFT--G
R
E
F
F
L
KDHVIKGE--HVL
P
G
A
A
L
L
E
M
V
R
A
A
V
E
R
A
A
ADQ-FPTGF
R
L
R
N
I
V
W
VRPFAVTEQQKD
I
D
V
R
L
Y
PEENG
E
I
T
F
E
I
CRDPESAEES
P
I
V
YGQG
S
A
V
L
C
EAGEN--
P
V
I
N
---
I
E
E
L
K
AS---YNGRTL
S
P
F
D
C
Y
E
A
Y
T
E
M
GIHYGDSH
R
A
I
D
S
LYAGEN
G
V
L
V
K
LTMPPVISD-TED
H
Y
I
L
H
P
S
M
---
I
D
S
A
F
Q
A
S
I
G
L
RLGGATSLEDRKAMLP
F
A
I
Q
D
V
R
I
FKGCEA
S
M
W
A
R
I
T
YSEGSTAGD
R
M
Q
K
L
D
I
D
LCNEEG
Q
V
C
V
R
LTSY
S
A
R
V
L
ETDQEGPSEANDT
L
L
F
E
H
I
W
E
E
R
A
A
E
R
Q
E
L
IEYD
T
Y
K
V
V
V
CD
V
G
E
Q
M
E
S
L
Q
N
HL
D
C
T
V
LQH
D
T
E
T
I
D
E
R
FE
G
Y
A
I
Q
L
F
E
E
I
K
Q
L
M
HSKTGG
H
T
F
I
Q
V
AVPALD
E
P
Q
L
L
S
G
L
T
G
L
L
K
T
AELENPKLT
G
Q
L
I
E
I
ETGM
S
A
G
E
L
F
E
I
L
E
ENRRYPRDTHIRHWQ
G
K
R
F
V
S
K
W
K
E
VSGEHLSADMPWKDK
G
V
Y
L
I
TGGAG
G
L
G
F
I
F
A
T
E
IANQTN
D
A
V
V
I
LTGRSP
L
D
E
R
K
K
K
K
L
K
A
L
Q
K
L
G
I
Q
A
I
Y
R
QADLA
D
K
Q
T
V
D
A
L
L
K
E
T
Q
N
V
Y
G
D
L
D
G
I
I
H
S
AGLIKD
N
F
I
M
K
K
K
K
E
E
V
Q
T
V
L
A
P
K
V
A
G
L
I
H
LDEATKDIP
L
D
F
F
I
L
FSSGAGAVGSAGQ
A
D
Y
A
M
A
N
A
F
M
N
A
F
S
E
YR
N
G
Q
A
E
L
H
K
R
YGK
T
L
S
V
CWPLWKDG
G
M
Q
I
D
A
E
T
A
R
M
L
K
RET
G
M
V
A
M
ETDR
G
I
Q
A
L
Y
HGWTSGK
P
Q
V
L
V
ASG
V
T
D
R
I
R
A
F
L
H
ETGHGKGQSHNI
K
K
S
SLN
Q
E
A
E
K
A
D
M
I
G
E
I
D
E
E
I
L
R
E
K
A
E
N
Y
F
K
Q
V
L
S
S
V
I
KLPAGQIDAEAP
L
E
DYGI
D
S
I
M
I
M
HVTG
Q
L
E
K
V
F
G
S
L
S
K
T
L
F
F
E
Y
Q
D
I
R
S
L
T
R
Y
F
I
D
S
R
R
E
K
L
L
D
I
LGFETGKPSVERKSEP
E
K
QEI
P
V
IPRKSGFLPLQ
D
K
E
Q
K
Q
V
R
E
KETE
E
I
A
I
I
G
ISGRYPQAD
N
I
D
E
L
W
E
K
L
RDG
R
D
C
I
T
EIPADRWDHS
L
Y
YDEDKDKPGK
T
Y
S
K
W
G
G
F
M
K
D
V
D
KFDP
Q
F
F
H
ISPREAKLM
D
P
Q
E
R
L
F
L
Q
C
V
Y
E
T
M
E
DAG
Y
T
R
E
H
LGRKR---
D
A
ELG---GS
V
G
V
Y
V
G
V
M
Y
E
E
Y
Q
--LYG
A
Q
E
QVRG-
R
S
L
A
L-TG
N
P
S
S
I
A
NR
V
S
Y
Y
F
DFHGP
S
I
A
L
D
T
M
CSS
S
L
T
A
I
H
L
A
C
Q
SLQRGEC
E
A
A
FAG
G
V
N
V
S
IHPN
K
Y
L
M
LGQNKFMS-SKGRCESFGQGGDGYVPGE
G
V
G
A
V
L
L
K
P
L
S
K
A
VEDGD
H
I
Y
G
I
I
K
G
T
A
INHGGKTNGYSVPNPN
A
Q
A
D
V
I
K
K
A
F
V
EAKVDP
R
T
V
S
Y
I
E
AHGTGTSLGD
P
I
E
I
TG
L
S
K
V
FTQETD---DK-----
Q
F
C
AIGSAKSNIGH
C
E
S
AA
G
I
A
G
V
T
K
V
L
L
Q
M
K
Y
R
Q
L
A
P
S
L
H
S
NVLNPNIDFLNS
P
F
K
V
Q
Q
E
L
E
E
WKR
P
I
I
S
VNGKD-IELPRIAGVSSFGAGG
V
N
A
H
I
L
I
EEYAPE
P
V
E
E
RLPA-RKQ
P
A
V
I
V
L
SAK
N
E
E
R
L
Q
K
R
A
E
R
L
L
H
A
I
R
E
Q
T
Y
V
E
A
D
L
H
R
I
A
Y
T
L
Q
V
G
R
E
A
M
K
E
R
L
A
F
V
A
E
T
M
Q
E
L
E
E
K
L
Y
E
C
ISG----TEN
R
E
Y
V
Y
RGQVKS
N
K
E
A
I
A
A
FAAD
E
D
M
S
K
T
I
E
A
W
L
QKGK
Y
A
K
V
L
D
L
W
V
R
GLRI
D
W
S
T
L
YQD-QKP
R
R
ISLPAYPFAR
D
R
Y
W
I
DVNAKAEEKRTEEPFAPVQPVIPKPSVDREASGKPA
N
I
T
L
Q
PLMT
N
Q
D
R
L
E
RVPSDTET
E
T
I
T
A
E
A
L
C
D
E
L
T
A
G
L
A
E
V
L
YMDQNEIDP
D
E
A
F
I
DI--G
M
D
SI
T
G
L
E
W
-
I
K
A
I
N
-
K
QYGTSLN
V
T
K
V
YDYPTT
R
D
F
A
V
Y
L
------------
A
H
E
L
S
TQAGEKKQTETYTPIRQKTVVPAAKPAN
I
S
LQP-LEHHQ
P
V
Q
E
E
A
E
E
T
I
Q
Y
A
A
A
EISASR
Q
Y
T
V
A
I
E
T
L
H
E
N
L
R
E
S
I
A
D
V
LYMEPYEV
D
I
D
E
A
F
I
D
IG
M
D
SI
T
G
L
E
W
I
K
A
V
N
K
QYGT
S
F
T
V
T
R
V
YDYP
T
I
R
D
F
A
E
M
L
K
S
E
L
G
T
H
L
D
R
KIEHTD
S
F
E
A
A
QQKPAASSHPKPAERPL
Q
P
V
Q
H
P
I
K
K
EHEKKTVPVLQDRPE
D
A
I
A
I
V
GMSGRYP-GA
R
N
V
R
E
Y
W
D
N
L
V
H
A
R
N
A
I
R
DIPTSR-W
D
V
D
K
Y
Y
D
P
V
LNKKG
K
V
Y
C
K
SMGMLD
D
I
E
HFD
P
L
F
FNIPP
S
E
A
ELMDP
Q
H
R
I
F
L
Q
E
G
Y
K
A
F
E
DAGYNARTLNEKK
C
G
V
Y
L
G
I
MSNE
Y
G
V
M
L
NRQSRANATGN
S
F
A
I
A
A
A
RI
P
Y
F
L
NLKGPAIPIDTACS
S
S
L
V
G
T
H
L
A
R
Q
A
L
I
NKEI
D
M
A
L
VG
G
V
S
L
Y
L
T
P
E
S
Y
M
S
M
C
E
AGMLSPDGQ
C
K
AFDNGANGFVPGEG
A
G
A
L
V
L
K
R
L
KDAEADR
D
H
I
Y
G
I
I
I
GSGINQDGKTNGITAPSAKS
Q
M
D
L
E
R
D
I
Y
E
T
YGIHPE
S
I
S
Y
V
E
MHGTGTKQGDP
I
E
L
E
A
L
S
T
V
F
Q
EKT
D
K
K
Q
F
C
AIGS
V
K
SNIGHT
S
A
A
A
G
V
A
G
V
Q
K
V
L
L
CMNHKTL
V
P
T
LNFTTPNE
H
F
EFEHS
P
L
Y
VNTELKPWETADGK
P
R
R
A
C
V
S
SFGYSGT
N
A
H
I
V
I
EEYQPEKRN
D
R
L
T
K
Q
H
R
S
A
L
F
V
L
SAK
K
E
K
Q
L
K
A
Y
A
E
A
M
K
D
F
VTSNEDI
D
L
E
D
M
A
Y
T
L
Q
TG
R
E
A
M
D
Y
R
M
A
F
LA
D
S
R
E
M
L
I
K
A
L
D
D
Y
L
A
EMPNG
S
I
F
A
A
H
V
KTKK
S
E
I
K
L
F
-------ETDH
D
A
K
A
L
L
Q
T
W
I
E
-
K
K
R
L
E
K
V
A
E
L
W
V
KGLQI
D
W
N
K
L
YGEYTP
R
R
ISLPAYPF
A
E
E
Y
Y
WLPTQEGEP
E
T
I
A
T
AM
P
Q
FEL
M
P
K
R
C
F
L
R
KQWQPCPI
E
P
A
EMTN
Q
T
V
A
I
L
AN
E
E
T
M
A
L
A
E
E
L
S
A
Y
F
S
T
YRIF-
D
S
Q
E
L
D
R
VSAA
D
Y
E
H
V
AG
A
I
D
L
I
GCGTSHEHS
M
G
W
I
N
W
L
Q
K
L
I
EQGRASK
H
H
L
T
V
L
G
VT---K
G
L
E
A
YANE
G
V
L
LSGA
S
R
A
G
L
Y
R
M
L
Q
S
E
Y
S
H
L
T
S
RHADMECEA
S
H
E
E
L
A
R
L
I
A
V
E
Y
YAKSTESEVCYRNG
Q
R
Y
R
A
Y
LTEQ
P
A
E
A
A
LSHKQVSFST
D
K
V
L
L
I
T-------GGT
R
G
L
G
L
L
C
A
R
H
F
V
K
T
YG
V
K
R
L
V
L
IGREELPPRDQWNSV
K
I
S
S
L
A
E
K
I
K
A
V
Q
E
L
E
DMGA
Q
V
Q
V
L
S
LDL
T
D
R
V
A
V
E
Q
S
L
K
T
I
H
E
T
M
G
A
I
G
G
V
I
H
C
AGMVNKQ
N
P
A
F
I
R
K
S
L
E
E
I
G
Q
V
L
E
P
K
V
E
G
L
Q
T
L
F
D
L
LQDE
P
L
A
F
F
T
L
F
S
S
V
S
A
A
I
P
A
L
AAGQ
A
D
Y
A
M
A
N
A
F
M
D
Y
F
A
E
A
HQDKC
P
I
V
S
I
QWPNWKET
G
L
G
E
V
R
S
K
A
L
E
QTG
L
I
S
LTND
E
G
L
Q
L
L
D
Q
I
LSDR
Q
Y
A
V
V
L
PAVPDTNVWKPDKLMQPSLP
V
E
ALSHPETKEQTSTRNL
F
P
E
T
V
D
W
L
V
T
L
F
SDE
L
K
I
AAEDFETDE
P
F
Q
E
YG
I
D
S
I
I
L
A
Q
L
V
Q
Q
M
N
Q
QLNGDI
D
P
S
I
L
F
EYP
T
I
E
S
F
A
H
W
L
I
S
KY
D
I
S
A
VLQPSVPEKQTPLK
P
Q
S
A
M
K
Q
KLVPEQR
P
Q
Q
I
S
H
E
K
T
A
L
L
A
E
D
I
A
I
I
G
L
S
CRFP
G
A
E
T
L
E
E
Y
W
D
L
I
RDG
R
S
AIAPV
P
P
E
RFGNSSSN
Y
A
G
L
I
D
E
M
N
RFDH
D
F
F
M
MSESDVRAM
D
P
Q
A
L
A
V
L
E
E
S
L
K
L
W
Y
HAGY
T
E
K
E
V
KGMRA
G
V
Y
IGGRSQHKPDP
A
S
L
S
KAKN
P
I
VAGG
Q
N
Y
L
A
A
N
I
S
Q
F
FDLKG
P
S
I
V
L
DT
A
C
S
S
A
L
V
G
L
N
M
A
I
Q
A
L
RSGDI
E
A
A
V
VG
G
V
S
LL
D
A
D
A
H
R
M
F
H
E
RGLLCDKPS
F
H
I
F
DKRAD
G
V
I
LGEG
V
G
M
V
L
V
K
T
V
N
Q
A
VEDG
D
S
I
Y
A
V
I
K
A
A
A
INNDGRTAGPSSPN
L
E
A
Q
K
D
V
M
L
S
A
L
E
KSGKKT
E
E
I
S
Y
L
EANGS
G
S
A
V
T
D
L
L
E
L
K
A
I
Q
S
I
Y
RSESKAPLGLGSVKPNIGH
P
L
C
A
E
G
I
A
S
L
I
K
V
A
L
M
L
K
H
R
QLVPFLSGNENM
P
Y
F
DIEK
T
D
L
Y
F
SRSQAEWKETTPA
A
A
I
N
C
FADGG
T
N
A
H
L
I
I
EGWRDSAERPIRRKPLPLPELNRQ
P
V
L
IKP
S
A
Q
N
V
Q
K
K
VHSDTGASKD
M
F
W
KTFK
2
PsiBlast_PDB
80.51
99%
-86
- C2 -
5E5N
-
PKSL_BACSU
A:
[3-591]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
A
I
V
G
M
S
G
R
Y
P
-
G
A
R
N
V
R
E
Y
W
D
N
L
V
H
A
R
N
A
I
R
D
I
P
T
S
R
-
W
D
V
D
K
Y
Y
D
P
V
-----
K
V
Y
C
K
S
M
G
M
L
D
D
I
E
H
F
D
P
L
F
F
N
I
P
P
S
E
A
E
L
M
D
P
Q
H
R
I
F
L
Q
E
G
Y
K
A
F
E
D
A
G
Y
N
A
R
T
L
N
E
K
K
C
G
V
Y
L
G
I
M
S
N
E
Y
G
V
M
L
N
--------
G
N
S
F
A
I
A
A
A
R
I
P
Y
F
L
N
L
K
G
P
A
I
P
I
D
T
A
S
S
S
S
L
V
G
T
H
L
A
R
Q
A
L
I
N
K
E
I
D
M
A
L
V
G
G
V
S
L
Y
L
T
P
E
S
Y
M
S
M
--
A
G
M
L
S
P
D
G
Q
C
K
A
F
D
N
G
A
N
G
F
V
P
G
E
G
A
G
A
L
V
L
K
R
L
K
D
A
E
A
D
R
D
H
I
Y
G
I
I
I
G
S
G
I
N
Q
D
G
K
T
N
G
I
T
A
P
S
A
K
S
Q
M
D
L
E
R
D
I
Y
E
T
Y
G
I
H
P
E
S
I
S
Y
V
E
M
H
G
T
G
T
K
Q
G
D
P
I
E
L
E
A
L
S
T
V
F
Q
E
K
T
D
K
K
Q
F
C
A
I
G
S
V
K
S
N
I
G
H
T
S
A
A
A
G
V
A
G
V
Q
K
V
L
L
C
M
N
H
K
T
L
V
P
T
L
N
F
T
T
P
N
E
H
F
E
F
E
H
S
P
L
Y
V
N
T
E
L
K
P
W
E
T
A
D
G
K
P
R
R
A
C
V
S
S
F
G
Y
S
G
T
N
A
H
I
V
I
E
E
Y
Q
P
E
-----------
S
A
L
F
V
L
S
A
K
K
E
K
Q
L
K
A
Y
A
E
A
M
K
D
F
V
T
S
N
E
D
I
D
L
E
D
M
A
Y
T
L
Q
T
G
R
E
A
M
D
Y
R
M
A
F
L
A
D
S
R
E
M
L
I
K
A
L
D
D
Y
L
A
E
M
P
N
G
S
I
F
A
A
H
V
K
T
K
K
S
E
I
K
L
F
-------
E
T
D
H
D
A
K
A
L
L
Q
T
W
I
E
-
K
K
R
L
E
K
V
A
E
L
W
V
K
G
L
Q
I
D
W
N
K
L
Y
G
E
Y
T
P
R
R
I
S
L
P
A
Y
P
F
A
E
E
Y
Y
W
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.33
100%
-89
- C2 -
5ERF
-
PKSL_BACSU
A:
[3-591]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
A
I
V
G
M
S
G
R
Y
P
-
G
A
R
N
V
R
E
Y
W
D
N
L
V
H
A
R
N
A
I
R
D
I
P
T
S
R
-
W
D
V
D
---------------
K
S
M
G
M
L
D
D
I
E
H
F
D
P
L
F
F
N
I
P
P
S
E
A
E
L
M
D
P
Q
H
R
I
F
L
Q
E
G
Y
K
A
F
E
D
A
G
Y
N
A
R
T
L
N
E
K
K
C
G
V
Y
L
G
I
M
S
N
E
Y
G
V
M
L
N
--------
G
N
S
F
A
I
A
A
A
R
I
P
Y
F
L
N
L
K
G
P
A
I
P
I
D
T
A
C
S
S
S
L
V
G
T
H
L
A
R
Q
A
L
I
N
K
E
I
D
M
A
L
V
G
G
V
S
L
Y
L
T
P
E
S
Y
M
S
M
C
E
A
G
M
L
S
P
D
G
Q
C
K
A
F
D
N
G
A
N
G
F
V
P
G
E
G
A
G
A
L
V
L
K
R
L
K
D
A
E
A
D
R
D
H
I
Y
G
I
I
I
G
S
G
I
N
Q
D
G
K
T
N
G
I
T
A
P
S
A
K
S
Q
M
D
L
E
R
D
I
Y
E
T
Y
G
I
H
P
E
S
I
S
Y
V
E
M
H
G
T
G
T
K
Q
G
D
P
I
E
L
E
A
L
S
T
V
F
Q
E
K
T
D
K
K
Q
F
C
A
I
G
S
V
K
S
N
I
G
H
T
S
A
A
A
G
V
A
G
V
Q
K
V
L
L
C
M
N
H
K
T
L
V
P
T
L
N
F
T
T
P
N
E
H
F
E
F
E
H
S
P
L
Y
V
N
T
E
L
K
P
W
E
T
A
D
G
K
P
R
R
A
C
V
S
S
F
G
Y
S
G
T
N
A
H
I
V
I
E
E
Y
Q
-------------
S
A
L
F
V
L
S
A
K
K
E
K
Q
L
K
A
Y
A
E
A
M
K
D
F
V
T
S
N
E
D
I
D
L
E
D
M
A
Y
T
L
Q
T
G
R
E
A
M
D
Y
R
M
A
F
L
A
D
S
R
E
M
L
I
K
A
L
D
D
Y
L
A
E
M
P
N
G
S
I
F
A
A
H
V
K
T
K
K
S
E
I
K
L
F
-------
E
T
D
H
D
A
K
A
L
L
Q
T
W
I
E
-
K
K
R
L
E
K
V
A
E
L
W
V
K
G
L
Q
I
D
W
N
K
L
Y
G
E
Y
T
P
R
R
I
S
L
P
A
Y
P
F
A
E
E
Y
Y
W
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
75.71
28%
0
- C- -
2VZ8
-
?
A:
[2-1214]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
V
V
I
A
G
M
S
G
K
L
P
E
S
E
N
L
E
E
F
W
A
N
L
I
G
G
V
D
M
V
T
A
-
D
D
R
R
W
K
A
G
L
Y
-----------
G
L
P
R
R
M
G
K
L
K
D
L
S
R
F
D
A
S
F
F
G
V
H
S
K
Q
A
N
T
M
D
P
Q
L
R
M
L
L
E
V
T
Y
E
A
I
V
D
G
G
I
N
P
A
S
L
R
G
----------
T
S
T
G
V
W
V
G
V
S
S
S
D
A
S
E
A
L
S
R
D
P
E----
T
L
V
G
Y
-
S
M
I
G
C
Q
R
A
M
M
A
N
R
L
S
F
F
F
D
F
K
G
P
S
I
T
I
D
T
A
C
S
S
S
L
L
A
L
Q
S
A
Y
Q
A
I
R
G
G
E
C
S
A
A
V
V
G
G
L
N
V
L
L
K
P
N
S
S
L
Q
F
M
K
L
G
M
L
S
Q
D
-
G
T
C
R
S
F
D
A
E
G
T
G
Y
C
R
A
E
A
V
V
A
V
L
L
T
K
K
S
L
A
R
----
R
V
Y
A
T
I
L
N
A
G
T
N
T
D
G
S
K
-
E
Q
G
V
T
F
P
S
G
D
V
Q
E
Q
L
I
R
S
L
Y
A
P
A
G
P
D
P
E
S
L
E
Y
I
E
A
H
G
T
G
T
K
V
G
D
P
Q
E
L
N
G
I
V
N
A
L
C
A
T
----
R
R
E
P
L
L
I
G
S
T
K
S
N
M
G
H
P
E
P
A
S
G
V
A
A
L
I
K
V
L
L
S
L
E
H
G
V
W
A
P
N
L
H
Y
H
T
P
N
P
E
I
P
A
L
Q
D
G
R
L
Q
V
V
D
R
P
L
P
I
R
-------------
G
G
N
V
G
I
N
S
F
G
F
G
G
S
N
V
H
V
I
L
Q
P
N
S
R
P
A
P
P
P
----
A
Q
H
A
A
L
P
R
L
L
Q
A
S
G
R
T
L
E
A
V
Q
T
L
L
E
Q
G
L
R
H
S
R
D
----
L
A
F
V
G
M
L
N
E
I
A
A
V
S
P
V
A
M
P
F
R
G
Y
A
V
L
G
G
E
A
G
S
Q
E
V
Q
Q
V
P
G
S
K
R
P
V
W
F
I
C
S
G
M
GAQWQGMGLSLMRL
D
R
F
R
D
S
I
L
R
S
D
Q
A
L
KPLGLR
V
S
D
L
L
L
S
TD
E
A
V
L
D
D
I
V
S
S
F
V
S
L
T
S
I
Q
I
A
L
I
D
L
L
T
S
L
GLQPD
G
I
I
G
H
SL
G
E
V
A
C
G
Y
A
D
GCLT
Q
E
E
A
V
L
S
S
Y
W
R
G
Y
C
I
K
E
A
NV
L
P
G
A
M
A
A
V
GLS
W
E
E
C
K
Q
RCPPGIVP
A
C
HNSKD
T
V
T
I
S
G
P
Q
A
A
M
S
E
F
L
Q
QLKRED
V
F
V
K
E
V
R
T
G
G
I
A
FHSYFMESI
A
P
T
L
L
R
Q
L
R
K
V
I
LD
P
K
P
R
S
KRWLSTSIPEAQWQGSLARTFS
A
E
Y
S
V
N
N
L
V
S
P
-------
V
L
F
Q
E
A
L
Q
H
VPAH
A
V
V
V
E
I
A
PHALL
Q
A
V
L
K
R
S
L
ESS
C
T
I
I
P
LMKKDHRD
N
L
E
F
F
L
S
N
V
G
R
L
H
L
A
G
V
-
S
V
N
P
N
G
L
F
P
P
-
V
EFPAP
R
G
T
P
L
I
S
P
H
I
K
W
D
H
S
Q
A
W
D
V
P
S
A
A
D
F
P
S
--------------
G
S
S
--
C
S
-
S
V
A
V
Y
K
F
D
V
S
PE
S
P
D
H
Y
L
V
D
H
C
I
D
G
R
--
V
L
F
P
G
T
G
Y
L
W
L
T
W
K
T
L
A
R
A
L
S
Q
N
L
E
E
T
P
V
V
F
E
D
V
T
L
H
Q
A
T
I
L
P
K
T
G
-
T
V
S
L
E
V
R
L
L
-
E
A
S
H
A
F
E
V
S
D
S
------
N
G
S
L
I
A
S
G
K
V
Y
Q
W
E
S
P
D
P
--
K
L
F
D
TRA
A
V
D
P
A
D
S
---
T
A
E
F
R
L
S
Q
G
D
V
Y
K
D
L
R
L
R
G
Y
D
Y
G
P
F
F
Q
L
V
L
E
S
D
L
E
G
N
R
G
R
L
--
Q
W
-----------
N
D
S
W
V
S
F
---
L
D
A
M
L
H
M
S
I
L
A
P
-------
G
Q
L
G
L
Y
L
P
T
R
F
T
S
I
R
I
D
P
V
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
75.68
99%
-90
- C2 -
5E6K
1
B:
[23-613]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
A
I
A
I
V
G
M
S
G
R
Y
P
-
G
A
R
N
V
R
E
Y
W
D
N
L
V
H
A
R
N
A
I
R
D
I
P
T
S
R
-
W
-----------------
C
K
S
M
G
M
L
D
D
I
E
H
F
D
P
L
F
F
N
I
P
P
S
E
A
E
L
M
D
P
Q
H
R
I
F
L
Q
E
G
Y
K
A
F
E
D
A
G
Y
N
A
R
T
L
N
E
K
K
C
G
V
Y
L
G
I
M
S
N
E
Y
G
V
M
L
N
R
Q
S
----
T
G
N
S
F
A
I
A
A
A
R
I
P
Y
F
L
N
L
K
G
P
A
I
P
I
D
T
A
S
S
S
S
L
V
G
T
H
L
A
R
Q
A
L
I
N
K
E
I
D
M
A
L
V
G
G
V
S
L
Y
L
T
P
E
S
Y
M
S
M
C
-------------------
G
F
V
P
G
E
G
A
G
A
L
V
L
K
R
L
K
D
A
E
A
D
R
D
H
I
Y
G
I
I
I
G
S
G
I
N
Q
D
G
K
T
N
G
I
T
A
P
S
A
K
S
Q
M
D
L
E
R
D
I
Y
E
T
Y
G
I
H
P
E
S
I
S
Y
V
E
M
H
G
T
G
T
K
Q
G
D
P
I
E
L
E
A
L
S
T
V
F
Q
E
K
T
D
K
K
Q
F
C
A
I
G
S
V
K
S
N
I
G
H
T
S
A
A
A
G
V
A
G
V
Q
K
V
L
L
C
M
N
H
K
T
L
V
P
T
L
N
F
------
F
E
F
E
H
S
P
L
Y
V
N
T
E
L
K
P
W
E
T
A
D
G
K
P
R
R
A
C
V
S
S
F
G
Y
S
G
T
N
A
H
I
V
I
E
E
Y
Q
P
E
K
----------
S
A
L
F
V
L
S
A
K
K
E
K
Q
L
K
A
Y
A
E
A
M
K
D
F
V
T
S
N
E
D
I
D
L
E
D
M
A
Y
T
L
Q
T
G
R
E
A
M
D
Y
R
M
A
F
L
A
D
S
R
E
M
L
I
K
A
L
D
D
Y
L
A
E
M
P
N
G
S
I
F
A
A
H
V
K
T
K
K
S
E
I
K
-----------
D
H
D
A
K
A
L
L
Q
T
W
I
E
-
K
K
R
L
E
K
V
A
E
L
W
V
K
G
L
Q
I
D
W
N
K
L
Y
G
E
Y
T
P
R
R
I
S
L
P
A
Y
P
F
A
E
E
Y
Y
W
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
67.41
76%
-60
- C2 -
5ERB
-
?
A:
[6-615]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
D
I
A
I
I
G
I
S
G
R
Y
P
Q
A
E
N
L
Q
E
F
W
K
N
L
S
E
G
T
D
C
I
T
E
I
P
N
D
R
W
D
H
S
L
Y
Y
D
A
D
K
D
K
E
G
K
T
Y
G
K
W
G
G
F
L
K
D
V
D
K
F
D
P
Q
F
F
S
I
S
P
R
D
A
K
L
M
D
P
Q
E
R
L
F
L
Q
C
V
Y
E
T
M
E
D
A
G
Y
T
R
K
K
L
T
E
K
S
---
G
D
L
L
G
---
A
N
V
G
V
Y
V
G
V
M
Y
E
E
Y
Q
--
L
Y
G
A
E
E
Q
A
R
--------
T
G
N
P
S
S
I
A
N
R
A
S
Y
V
F
G
F
N
G
P
S
M
A
L
D
T
M
C
S
S
S
L
T
A
I
H
L
A
C
Q
S
L
R
N
G
E
C
E
A
A
F
A
G
G
V
N
V
S
V
H
P
N
K
Y
L
M
L
G
Q
N
R
F
L
S
-
S
K
G
R
C
E
S
F
G
E
G
G
D
G
Y
V
P
G
E
G
V
G
A
V
L
L
K
P
L
S
K
A
K
A
D
G
D
H
I
Y
G
L
I
K
G
T
A
V
N
H
D
G
K
T
N
G
Y
S
V
P
N
P
N
A
Q
A
A
V
I
K
Q
A
L
K
D
A
G
T
D
P
R
A
V
S
Y
I
E
A
H
G
T
G
T
S
L
G
D
P
I
E
I
T
G
L
T
K
A
F
S
E
Q
T
Q
----------
Q
F
C
A
I
G
S
A
K
S
N
I
G
H
C
E
S
A
A
G
I
A
G
L
T
K
V
L
L
Q
M
K
H
K
Q
L
A
P
S
L
H
S
R
T
L
N
P
N
I
D
F
L
A
T
P
F
K
V
Q
Q
T
L
E
E
W
K
R
P
V
I
N
E
N
------
L
P
R
T
A
G
L
S
S
F
G
A
G
G
V
N
A
H
I
V
I
E
E
Y
S
------------
P
H
P
S
M
I
V
L
S
A
K
N
E
Q
R
L
Q
K
R
A
K
R
L
L
D
A
L
R
S
G
R
Y
R
E
A
D
L
S
R
I
A
Y
T
L
Q
V
G
R
E
P
M
E
E
R
L
G
M
I
V
S
N
L
R
E
L
E
E
K
L
D
E
F
T
G
G
----
K
E
S
I
D
Q
L
Y
R
G
Q
--
Q
N
K
D
T
M
A
L
F
T
A
D
E
D
M
E
K
T
I
E
A
W
L
E
K
G
K
A
A
K
V
L
E
L
W
V
K
G
L
P
L
N
W
D
K
L
Y
Q
M
-
G
R
P
Q
K
I
S
L
P
A
Y
P
F
A
K
D
R
Y
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.41
76%
-60
- C2 -
5ERB
-
?
A:
[6-615]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
D
I
A
I
I
G
I
S
G
R
Y
P
Q
A
E
N
L
Q
E
F
W
K
N
L
S
E
G
T
D
C
I
T
E
I
P
N
D
R
W
D
H
S
L
Y
Y
D
A
D
K
D
K
E
G
K
T
Y
G
K
W
G
G
F
L
K
D
V
D
K
F
D
P
Q
F
F
S
I
S
P
R
D
A
K
L
M
D
P
Q
E
R
L
F
L
Q
C
V
Y
E
T
M
E
D
A
G
Y
T
R
K
K
L
T
E
K
S
---
G
D
L
L
G
---
A
N
V
G
V
Y
V
G
V
M
Y
E
E
Y
Q
--
L
Y
G
A
E
E
Q
A
R
--------
T
G
N
P
S
S
I
A
N
R
A
S
Y
V
F
G
F
N
G
P
S
M
A
L
D
T
M
C
S
S
S
L
T
A
I
H
L
A
C
Q
S
L
R
N
G
E
C
E
A
A
F
A
G
G
V
N
V
S
V
H
P
N
K
Y
L
M
L
G
Q
N
R
F
L
S
-
S
K
G
R
C
E
S
F
G
E
G
G
D
G
Y
V
P
G
E
G
V
G
A
V
L
L
K
P
L
S
K
A
K
A
D
G
D
H
I
Y
G
L
I
K
G
T
A
V
N
H
D
G
K
T
N
G
Y
S
V
P
N
P
N
A
Q
A
A
V
I
K
Q
A
L
K
D
A
G
T
D
P
R
A
V
S
Y
I
E
A
H
G
T
G
T
S
L
G
D
P
I
E
I
T
G
L
T
K
A
F
S
E
Q
T
Q
----------
Q
F
C
A
I
G
S
A
K
S
N
I
G
H
C
E
S
A
A
G
I
A
G
L
T
K
V
L
L
Q
M
K
H
K
Q
L
A
P
S
L
H
S
R
T
L
N
P
N
I
D
F
L
A
T
P
F
K
V
Q
Q
T
L
E
E
W
K
R
P
V
I
N
E
N
------
L
P
R
T
A
G
L
S
S
F
G
A
G
G
V
N
A
H
I
V
I
E
E
Y
S
------------
P
H
P
S
M
I
V
L
S
A
K
N
E
Q
R
L
Q
K
R
A
K
R
L
L
D
A
L
R
S
G
R
Y
R
E
A
D
L
S
R
I
A
Y
T
L
Q
V
G
R
E
P
M
E
E
R
L
G
M
I
V
S
N
L
R
E
L
E
E
K
L
D
E
F
T
G
G
----
K
E
S
I
D
Q
L
Y
R
G
Q
--
Q
N
K
D
T
M
A
L
F
T
A
D
E
D
M
E
K
T
I
E
A
W
L
E
K
G
K
A
A
K
V
L
E
L
W
V
K
G
L
P
L
N
W
D
K
L
Y
Q
M
-
G
R
P
Q
K
I
S
L
P
A
Y
P
F
A
K
D
R
Y
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
67.15
33%
-77
- C2 -
4KC5
1
?
A:
[10-908]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
N
Y
I
A
V
I
G
L
G
G
Y
Y
P
G
A
D
S
I
D
E
L
W
Q
N
L
A
N
G
V
D
C
M
S
D
F
P
A
D
R
W
D
H
S
K
I
Y
Y
K
N
R
-
K
V
L
G
K
T
T
C
I
N
G
S
F
I
K
D
V
D
K
F
D
Y
S
Y
F
K
M
P
K
V
Y
A
D
H
M
S
P
E
V
R
L
F
L
Q
V
A
V
H
T
F
E
D
A
G
Y
S
K
E
T
L
L
S
R
-------
Y
N
G
D
V
G
V
L
L
G
T
M
S
N
D
Y
H
Y
Y
G
F
E
S
N
-----
V
F
R
G
S
-
M
A
S
G
S
G
M
A
T
I
P
M
T
V
S
Y
F
Y
G
L
T
G
P
S
L
F
I
D
T
M
C
S
S
S
S
T
C
I
H
T
A
C
Q
M
L
K
H
D
E
T
K
M
V
L
A
G
G
L
N
L
M
Y
H
P
Y
T
T
V
N
T
S
Q
G
N
F
T
S
I
T
S
E
S
V
N
S
Y
G
V
G
A
D
G
T
V
I
G
E
G
I
G
A
V
L
L
K
R
L
D
R
A
I
A
D
R
D
Q
I
Y
G
V
I
K
G
S
A
M
T
N
A
G
-
E
-
R
N
G
F
N
V
P
N
P
D
L
Q
T
L
A
I
R
Q
A
M
D
Q
A
K
V
H
P
S
S
I
S
Y
I
E
G
H
G
S
G
T
K
L
G
D
P
I
E
V
L
G
L
N
N
A
F
R
W
A
T
D
--
D
K
Q
F
C
Y
L
G
S
I
K
S
N
I
G
H
L
L
A
A
S
G
I
A
G
L
T
K
T
L
L
Q
F
K
H
K
Q
I
A
P
S
I
H
S
S
Q
L
N
Q
D
I
D
-
F
A
D
T
P
F
V
V
P
Q
Q
L
I
E
W
R
Q
P
E
R
I
I
N
G
R
K
Q
V
F
P
R
R
A
G
L
T
S
I
A
A
G
G
M
N
A
H
M
I
V
E
E
Y
P
E
P
A
D
S
A
----
G
Q
I
S
E
D
Q
L
V
F
V
F
S
V
H
K
L
A
L
L
A
Q
N
L
T
S
F
R
D
W
L
A
S
S---
E
A
P
L
A
Q
I
A
Y
T
L
Q
V
G
K
N
N
L
R
N
R
L
A
I
R
C
R
T
R
Q
A
L
S
R
A
-------------------------------------------------------
L
-----------------------------
N
A
C
------
I
D
----
G
H
Y
Q
-------------
S
------------------------------
S
-------------------
A
D
S
K
----------------------
I
F
-
Y
R
-----------------------
F
------------------------------------
Q
-------
E
S
D
A
V
Q
P
L
E
------------------
S
D
L
---------------------
N
D
P
L
A
P
L
L
T
Q
W
L
N
G
D
S
Q
V
D
W
A
S
L
Y
A
Q
-------
P
P
V
R
I
S
L
P
A
Y
R
F
E
K
T
R
C
W
Y
T
E
E
G
Y
E
S
S
I
V
NP
L
M
F
K
N
K
L
H
P
L
V
A
K
N
C
S
T
P
Q
P
G
A
I
F
R
T
D
F
V
--
E
D
E
--
L
L
D
Y
V
Y
S
G
R
G
G
R
R
L
S
A
F
N
F
A
D
V
A
L
A
M
P
A
L
A
S
R
-
F
-
D
G
R
T
L
S
V
S
-
C
A
F
E
H
Y
I
A
D
W
T
T
V
T
G
L
E
Y
R
L
F
E
I
D
S
E
Q
L
E
L
E
F
D
F
R
R
S
--
G
E
Q
P
T
H
L
G
F
A
V
I
N
P
L
T
S
D
E
P
PL
P
Q
Q
W
L
D
D
A
R
E
L
L
N
R
Q
A
L
Q
A
G
R
Q
L
S
A
A
E
V
S
Q
R
L
A
Q
A
G
Y
D
F
A
P
Y
L
D
H
D
G
E
L
T
I
G
R
S
G
L
V
L
K
G
R
P
P
V
N
R
H
N
H
Y
A
D
N
V
Q
L
S
P
Y
L
A
T
T
I
D
K
A
L
Y
L
L
L
D
E
L
G
------
L
P
Q
G
R
V
I
V
R
N
I
E
R
L
C
C
Y
H
T
P
A
G
G
F
S
V
V
L
S
G
---
I
G
L
N
D
N
E
L
S
L
S
L
L
V
L
D
E
R
E
Q
I
C
V
K
L
D
K
V
S
L
Y
L
G
K
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
66.05
48%
-75
- C2 -
4TKT
6
?
A:
[6-617]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
A
I
A
I
V
G
M
A
G
R
Y
P
G
A
P
D
L
D
T
F
W
E
N
L
L
A
G
R
D
S
I
T
E
I
P
A
G
R
W
D
H
S
R
Y
Y
D
A
-
R
R
G
V
P
G
R
T
Y
S
K
W
G
G
F
L
D
G
I
D
E
F
D
P
L
F
F
G
I
S
P
K
A
A
S
T
M
D
P
Q
E
R
L
F
L
Q
C
A
H
T
T
L
E
D
A
G
Y
S
R
G
A
L
R
A
A
A
R
A
R
V
A
E
D
A
G
D
I
G
V
F
A
G
A
M
Y
S
E
Y
Q
L
Y
G
A
E
Y
S
-----
V
R
G
E
P
-
V
V
V
P
G
S
L
A
S
I
A
N
R
V
S
Y
F
L
D
A
S
G
P
S
V
T
V
D
T
M
C
A
S
A
L
S
A
I
H
L
A
C
A
A
L
Q
R
G
E
C
G
V
A
L
A
G
G
V
N
L
S
V
H
P
G
K
Y
L
M
I
G
E
G
Q
F
A
S
S
D
-
G
R
C
R
S
F
G
E
G
G
D
G
Y
V
P
G
E
G
V
G
A
V
L
L
R
P
L
A
D
A
V
A
D
G
D
R
I
L
G
V
I
R
G
T
A
V
N
H
G
G
-
H
-
T
H
G
F
T
V
P
N
P
L
A
Q
A
A
V
I
R
S
A
W
R
R
A
G
V
D
P
R
D
I
G
C
I
E
A
H
G
T
G
T
S
L
G
D
P
I
E
I
A
G
L
N
A
A
F
A
E
F
T
D
--
A
R
N
F
C
A
I
G
S
A
K
S
N
I
G
H
L
E
S
A
A
G
I
A
G
L
A
K
L
L
L
Q
M
R
H
G
T
L
V
P
S
L
H
A
E
R
V
N
P
D
I
D
-
F
A
D
S
P
F
V
L
Q
R
E
A
A
P
W
P
R
T
G
--------
T
R
P
R
L
G
G
L
S
S
F
G
A
G
G
S
N
A
H
V
V
V
E
D
Y
V
E
-----------
H
R
G
E
T
V
V
V
V
L
S
A
F
D
E
E
R
L
R
E
S
A
G
R
L
R
D
A
L
R
K
ERWS
S
A
D
L
P
D
I
A
Y
T
L
Q
V
G
R
E
A
M
T
A
R
F
A
V
A
V
S
T
L
P
A
L
V
D
A
-------------------------------------------------------
L
-----------------------------
D
A
C
------
A
L
----
G
S
G
L
-------------
P
------------------------------
A
---------
G
A
--------
Y
F
N
P
----------------------
G
--------------------------------------------------------------------------
F
Q
E
T
A
V
R
------------------
W
A
R
---------------------
R
G
K
P
A
P
L
A
E
A
W
T
S
G
L
-
A
V
D
W
A
R
L
H
T
-G
P
-----
K
P
R
K
V
A
L
P
G
Y
P
F
A
R
E
R
Y
W
Y
T
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.63
50%
-71
- C2 -
4NA2
-
PKSJ_BACSU
A:
[5-613]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
V
A
I
V
G
I
S
G
R
F
P
G
A
M
D
I
D
E
F
W
K
N
L
E
E
G
K
D
S
I
T
E
V
P
K
D
R
W
D
W
R
E
H
Y
G
N
P
D
T
D
V
N
K
T
D
I
K
W
G
G
F
I
D
G
V
A
E
F
D
P
L
F
F
G
I
S
P
R
E
A
D
Y
V
D
P
Q
Q
R
L
L
M
T
Y
V
W
K
A
L
E
D
A
G
C
S
P
Q
S
L
S
----------
G
---
T
G
T
G
I
F
I
G
T
G
N
T
G
Y
K
D
L
F
H
R
A
N
L
P
I
E
G
-
H
A
A
T
G
-
H
M
I
P
S
V
G
P
N
R
M
S
Y
F
L
N
I
H
G
P
S
E
P
V
E
T
A
-
S
S
S
L
V
A
I
H
R
A
V
T
A
M
Q
N
G
D
C
E
M
A
I
A
G
G
V
N
T
I
L
T
E
E
A
H
I
S
Y
S
K
A
G
M
L
S
-
T
D
G
R
C
K
T
F
S
A
D
A
N
G
Y
V
R
G
E
G
V
G
M
V
M
L
K
K
L
E
D
A
E
R
D
G
N
H
I
Y
G
V
I
R
G
T
A
E
N
H
G
G
R
A
N
T
L
T
S
P
N
P
K
A
Q
A
D
L
L
V
R
A
Y
R
Q
A
D
I
D
P
S
T
V
T
Y
I
E
A
H
G
T
G
T
E
L
G
D
P
I
E
I
N
G
L
K
A
A
F
K
E
L
S
N
---
M
R
PDVPD
H
R
C
G
I
G
S
V
K
S
N
I
G
H
L
E
L
A
A
G
I
S
G
L
I
K
V
L
L
Q
M
K
H
K
T
L
V
K
S
L
H
C
E
T
L
N
P
Y
L
Q
L
T
D
S
P
F
Y
I
V
Q
E
K
Q
E
W
K
----
S
V
T
D
R
D
G
N
E
L
P
R
R
A
G
I
S
S
F
G
I
G
G
V
N
A
H
I
V
I
E
E
Y
M
P
------------
Q
P
N
V
I
V
L
S
A
K
N
K
S
R
L
I
D
R
A
S
Q
L
L
E
V
I
R
N
K
K
Y
T
D
Q
D
L
H
R
I
A
Y
T
L
Q
V
G
R
E
E
M
D
E
R
L
A
C
V
A
G
T
M
Q
E
L
E
E
K
L
Q
A
F
V
D
G
----
K
-----
F
F
R
G
Q
S
H
R
N
K
E
T
Q
T
I
F
T
A
D
E
D
M
A
L
A
L
D
A
W
I
R
K
R
K
Y
A
K
L
A
D
L
W
V
K
G
V
S
I
Q
W
N
T
L
Y
G
E
-
T
K
P
R
L
I
S
L
P
S
Y
P
F
A
K
D
H
Y
W
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
65.56
52%
-75
- C2 -
4NA1
2
PKSJ_BACSU
A:
[22-633]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
P
V
A
I
V
G
I
S
G
R
F
P
G
A
M
D
I
D
E
F
W
K
N
L
E
E
G
K
D
S
I
T
E
V
P
K
D
R
W
D
W
R
E
H
Y
G
N
P
D
T
D
V
N
K
T
D
I
K
W
G
G
F
I
D
G
V
A
E
F
D
P
L
F
F
G
I
S
P
R
E
A
D
Y
V
D
P
Q
Q
R
L
L
M
T
Y
V
W
K
A
L
E
D
A
G
C
S
P
Q
S
L
S
----------
G
---
T
G
T
G
I
F
I
G
T
G
N
T
G
Y
K
--
D
L
F
H
R
A
N
L
P
I
E
G
H
A
A
T
G
H
M
I
P
S
V
G
P
N
R
M
S
Y
F
L
N
I
H
G
P
S
E
P
V
E
T
A
C
S
S
S
L
V
A
I
H
R
A
V
T
A
M
Q
N
G
D
C
E
M
A
I
A
G
G
V
N
T
I
L
T
E
E
A
H
I
S
Y
S
K
A
G
M
L
S
-
T
D
G
R
C
K
T
F
S
A
D
A
N
G
Y
V
R
G
E
G
V
G
M
V
M
L
K
K
L
E
D
A
E
R
D
G
N
H
I
Y
G
V
I
R
G
T
A
E
N
H
G
G
R
A
N
T
L
T
S
P
N
P
K
A
Q
A
D
L
L
V
R
A
Y
R
Q
A
D
I
D
P
S
T
V
T
Y
I
E
A
H
G
T
G
T
E
L
G
D
P
I
E
I
N
G
L
K
A
A
F
K
E
L
S
N
MDV
P
D
-----
H
R
C
G
I
G
S
V
K
S
N
I
G
H
L
E
L
A
A
G
I
S
G
L
I
K
V
L
L
Q
M
K
H
K
T
L
V
K
S
L
H
C
E
T
L
N
P
Y
L
Q
L
T
D
S
P
F
Y
I
V
Q
E
K
Q
E
W
K
S
V
T
D
---
R
D
G
-
N
E
L
P
R
R
A
G
I
S
S
F
G
I
G
G
V
N
A
H
I
V
I
E
E
Y
M
P
-----------
E
Q
P
N
V
I
V
L
S
A
K
N
K
S
R
L
I
D
R
A
S
Q
L
L
E
V
I
R
N
K
K
Y
T
D
Q
D
L
H
R
I
A
Y
T
L
Q
V
G
R
E
E
M
D
E
R
L
A
C
V
A
G
T
M
Q
E
L
E
E
K
L
Q
A
F
V
D
G
----
K
E
E
T
D
E
F
F
R
G
Q
S
H
R
N
K
E
T
Q
T
I
F
T
A
D
E
D
M
A
L
A
L
D
A
W
I
R
K
R
K
Y
A
K
L
A
D
L
W
V
K
G
V
S
I
Q
W
N
T
L
Y
G
E
-
T
K
P
R
L
I
S
L
P
S
Y
P
F
A
K
D
H
Y
W
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
65.29
45%
-79
- C2 -
5E5N
-
PKSL_BACSU
A:
[3-591]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
A
I
V
G
M
S
G
R
Y
P
G
A
R
N
V
R
E
Y
W
D
N
L
V
H
A
R
N
A
I
R
D
I
P
T
S
R
W
D
V
D
K
Y
Y
D
P
V
-----
K
V
Y
C
K
S
M
G
M
L
D
D
I
E
H
F
D
P
L
F
F
N
I
P
P
S
E
A
E
L
M
D
P
Q
H
R
I
F
L
Q
E
G
Y
K
A
F
E
D
A
G
Y
N
A
R
T
L
N
----------
E
---
K
K
C
G
V
Y
L
G
I
M
S
N
E
Y
G
--
V
M
L
N
-------------
G
N
S
F
A
I
A
A
A
R
I
P
Y
F
L
N
L
K
G
P
A
I
P
I
D
T
A
S
S
S
S
L
V
G
T
H
L
A
R
Q
A
L
I
N
K
E
I
D
M
A
L
V
G
G
V
S
L
Y
L
T
P
E
S
Y
M
S
M
--
A
G
M
L
S
-
P
D
G
Q
C
K
A
F
D
N
G
A
N
G
F
V
P
G
E
G
A
G
A
L
V
L
K
R
L
K
D
A
E
A
D
R
D
H
I
Y
G
I
I
I
G
S
G
I
N
Q
D
G
K
T
N
G
I
T
A
P
S
A
K
S
Q
M
D
L
E
R
D
I
Y
E
T
Y
G
I
H
P
E
S
I
S
Y
V
E
M
H
G
T
G
T
K
Q
G
D
P
I
E
L
E
A
L
S
T
V
F
Q
E
K
T
D
---
K
K
-----
Q
F
C
A
I
G
S
V
K
S
N
I
G
H
T
S
A
A
A
G
V
A
G
V
Q
K
V
L
L
C
M
N
H
K
T
L
V
P
T
L
N
F
T
T
P
N
E
H
F
E
F
E
H
S
P
L
Y
V
N
T
E
L
K
P
W
E
T
A
D
---------
G
K
P
R
R
A
C
V
S
S
F
G
Y
S
G
T
N
A
H
I
V
I
E
E
Y
Q
P
E
------------
S
A
L
F
V
L
S
A
K
K
E
K
Q
L
K
A
Y
A
E
A
M
K
D
F
V
T
S
N
--
E
D
I
D
L
E
D
M
A
Y
T
L
Q
T
G
R
E
A
M
D
Y
R
M
A
F
L
A
D
S
R
E
M
L
I
K
A
L
D
D
Y
L
A
E
----
M
P
N
G
-
S
I
F
A
A
H
V
K
T
K
K
S
E
I
K
L
F
E
T
D
H
D
A
K
A
L
L
Q
T
W
I
E
K
K
R
L
E
K
V
A
E
L
W
V
K
G
L
Q
I
D
W
N
K
L
Y
G
E
-
Y
T
P
R
R
I
S
L
P
A
Y
P
F
A
E
E
Y
Y
W
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.12
50%
-74
- C2 -
4NA1
2
PKSJ_BACSU
A:
[24-632]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
V
A
I
V
G
I
S
G
R
F
P
G
A
M
D
I
D
E
F
W
K
N
L
E
E
G
K
D
S
I
T
E
V
P
K
D
R
W
D
W
R
E
H
Y
G
N
P
D
T
D
V
N
K
T
D
I
K
W
G
G
F
I
D
G
V
A
E
F
D
P
L
F
F
G
I
S
P
R
E
A
D
Y
V
D
P
Q
Q
R
L
L
M
T
Y
V
W
K
A
L
E
D
A
G
C
S
P
Q
S
L
S
----------
G
---
T
G
T
G
I
F
I
G
T
G
N
T
G
Y
K
D
L
F
H
R
A
N
L
P
I
E
G
-
H
A
A
T
G
-
H
M
I
P
S
V
G
P
N
R
M
S
Y
F
L
N
I
H
G
P
S
E
P
V
E
T
A
C
S
S
S
L
V
A
I
H
R
A
V
T
A
M
Q
N
G
D
C
E
M
A
I
A
G
G
V
N
T
I
L
T
E
E
A
H
I
S
Y
S
K
A
G
M
L
S
-
T
D
G
R
C
K
T
F
S
A
D
A
N
G
Y
V
R
G
E
G
V
G
M
V
M
L
K
K
L
E
D
A
E
R
D
G
N
H
I
Y
G
V
I
R
G
T
A
E
N
H
G
G
R
A
N
T
L
T
S
P
N
P
K
A
Q
A
D
L
L
V
R
A
Y
R
Q
A
D
I
D
P
S
T
V
T
Y
I
E
A
H
G
T
G
T
E
L
G
D
P
I
E
I
N
G
L
K
A
A
F
K
E
L
S
N
---
M
-DVPD-
H
R
C
G
I
G
S
V
K
S
N
I
G
H
L
E
L
A
A
G
I
S
G
L
I
K
V
L
L
Q
M
K
H
K
T
L
V
K
S
L
H
C
E
T
L
N
P
Y
L
Q
L
T
D
S
P
F
Y
I
V
Q
E
K
Q
E
W
K
----
S
V
T
D
R
D
G
N
E
L
P
R
R
A
G
I
S
S
F
G
I
G
G
V
N
A
H
I
V
I
E
E
Y
M
P
-----------
E
Q
P
N
V
I
V
L
S
A
K
N
K
S
R
L
I
D
R
A
S
Q
L
L
E
V
I
R
N
K
K
Y
T
D
Q
D
L
H
R
I
A
Y
T
L
Q
V
G
R
E
E
M
D
E
R
L
A
C
V
A
G
T
M
Q
E
L
E
E
K
L
Q
A
F
V
D
G
----
K
E
E
T
D
E
F
F
R
G
Q
S
H
R
N
K
E
T
Q
T
I
F
T
A
D
E
D
M
A
L
A
L
D
A
W
I
R
K
R
K
Y
A
K
L
A
D
L
W
V
K
G
V
S
I
Q
W
N
T
L
Y
G
E
-
T
K
P
R
L
I
S
L
P
S
Y
P
F
A
K
D
H
Y
W
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
64.71
50%
-73
- C2 -
4NA1
4
B:
[24-632]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
V
A
I
V
G
I
S
G
R
F
P
G
A
M
D
I
D
E
F
W
K
N
L
E
E
G
K
D
S
I
T
E
V
P
K
D
R
W
D
W
R
E
H
Y
G
N
P
D
T
D
V
N
K
T
D
I
K
W
G
G
F
I
D
G
V
A
E
F
D
P
L
F
F
G
I
S
P
R
E
A
D
Y
V
D
P
Q
Q
R
L
L
M
T
Y
V
W
K
A
L
E
D
A
G
C
S
P
Q
S
L
S
----------
G
---
T
G
T
G
I
F
I
G
T
G
N
T
G
Y
K
D
L
F
H
R
A
N
L
P
I
E
G
-
H
A
A
T
G
-
H
M
I
P
S
V
G
P
N
R
M
S
Y
F
L
N
I
H
G
P
S
E
P
V
E
T
A
C
S
S
S
L
V
A
I
H
R
A
V
T
A
M
Q
N
G
D
C
E
M
A
I
A
G
G
V
N
T
I
L
T
E
E
A
H
I
S
Y
S
K
A
G
M
L
S
-
T
D
G
R
C
K
T
F
S
A
D
A
N
G
Y
V
R
G
E
G
V
G
M
V
M
L
K
K
L
E
D
A
E
R
D
G
N
H
I
Y
G
V
I
R
G
T
A
E
N
H
G
G
R
A
N
T
L
T
S
P
N
P
K
A
Q
A
D
L
L
V
R
A
Y
R
Q
A
D
I
D
P
S
T
V
T
Y
I
E
A
H
G
T
G
T
E
L
G
D
P
I
E
I
N
G
L
K
A
A
F
K
E
L
S
N
---
M
R
D----
H
R
C
G
I
G
S
V
K
S
N
I
G
H
L
E
L
A
A
G
I
S
G
L
I
K
V
L
L
Q
M
K
H
K
T
L
V
K
S
L
H
C
E
T
L
N
P
Y
L
Q
L
T
D
S
P
F
Y
I
V
Q
E
K
Q
E
W
K
----
S
V
T
D
R
D
G
N
E
L
P
R
R
A
G
I
S
S
F
G
I
G
G
V
N
A
H
I
V
I
E
E
Y
M
P
------------
Q
P
N
V
I
V
L
S
A
K
N
K
S
R
L
I
D
R
A
S
Q
L
L
E
V
I
R
N
K
K
Y
T
D
Q
D
L
H
R
I
A
Y
T
L
Q
V
G
R
E
E
M
D
E
R
L
A
C
V
A
G
T
M
Q
E
L
E
E
K
L
Q
A
F
V
D
G
----
K
----
E
F
F
R
G
Q
S
H
R
N
K
E
T
Q
T
I
F
T
A
D
E
D
M
A
L
A
L
D
A
W
I
R
K
R
K
Y
A
K
L
A
D
L
W
V
K
G
V
S
I
Q
W
N
T
L
Y
G
E
-
T
K
P
R
L
I
S
L
P
S
Y
P
F
A
K
D
H
Y
W
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
63.37
56%
-76
- C2 -
4TKT
6
?
A:
[5-616]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
M
A
I
A
I
V
G
M
A
G
R
Y
P
G
A
P
D
L
D
T
F
W
E
N
L
L
A
G
R
D
S
I
T
E
I
P
A
G
R
W
D
H
S
R
Y
Y
D
A
R
R
G
V
P
G
R
T
Y
S
K
W
G
G
F
L
D
G
I
D
E
F
D
P
L
F
F
G
I
S
P
K
A
A
S
T
M
D
P
Q
E
R
L
F
L
Q
C
A
H
T
T
L
E
D
A
G
Y
S
R
G
A
L
R
A
A
A
R
A
R
V
A
E
D
A
---
G
D
I
G
V
F
A
G
A
M
Y
S
E
Y
Q
--
L
Y
G
A
E
Y
S
V
R
G
-
E
P
V
V
V
-
P
G
S
L
A
S
I
A
N
R
V
S
Y
F
L
D
A
S
G
P
S
V
T
V
D
T
M
C
A
S
A
L
S
A
I
H
L
A
C
A
A
L
Q
R
G
E
C
G
V
A
L
A
G
G
V
N
L
S
V
H
P
G
K
Y
L
M
I
G
E
G
Q
F
A
S
-
S
D
G
R
C
R
S
F
G
E
G
G
D
G
Y
V
P
G
E
G
V
G
A
V
L
L
R
P
L
A
D
A
V
A
D
G
D
R
I
L
G
V
I
R
G
T
A
V
N
H
G
G
H
T
H
G
F
T
V
P
N
P
L
A
Q
A
A
V
I
R
S
A
W
R
R
A
G
V
D
P
R
D
I
G
C
I
E
A
H
G
T
G
T
S
L
G
D
P
I
E
I
A
G
L
N
A
A
F
A
E
F
T
D
---
A
R
-----
N
F
C
A
I
G
S
A
K
S
N
I
G
H
L
E
S
A
A
G
I
A
G
L
A
K
L
L
L
Q
M
R
H
G
T
L
V
P
S
L
H
A
E
R
V
N
P
D
I
D
F
A
D
S
P
F
V
L
Q
R
E
A
A
P
W
P
R
T
G
---------
T
R
P
R
L
G
G
L
S
S
F
G
A
G
G
S
N
A
H
V
V
V
E
D
Y
V
E
--------
H
-
R
G
E
T
V
V
V
V
L
S
A
F
D
E
E
R
L
R
E
S
A
G
R
L
R
D
A
L
R
K
E
R
W
S
S
A
D
L
P
D
I
A
Y
T
L
Q
V
G
R
E
A
M
T
A
R
F
A
V
A
V
S
T
L
P
A
L
V
D
A
L
D
A
C
A
L
G
----
S
G
L
P
A
G
A
Y
F
N
P
G
---------------
F
Q
E
T
A
V
R
W
A
R
R
G
K
P
A
P
L
A
E
A
W
T
S
G
L
A
V
D
W
A
R
L
H
T
-G
P
K
P
R
K
V
A
L
P
G
Y
P
F
A
R
E
R
Y
W
Y
T
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
63.00
41%
-79
- C2 -
5E5N
-
PKSL_BACSU
A:
[3-591]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
A
I
V
G
M
S
G
R
Y
P
G
A
R
N
V
R
E
Y
W
D
N
L
V
H
A
R
N
A
I
R
D
I
P
T
S
R
W
D
V
D
K
Y
Y
D
P
V------
K
V
Y
C
K
S
M
G
M
L
D
D
I
E
H
F
D
P
L
F
F
N
I
P
P
S
E
A
E
L
M
D
P
Q
H
R
I
F
L
Q
E
G
Y
K
A
F
E
D
A
G
Y
N
A
R
T
L
N
E
----------
K
K
C
G
V
Y
L
G
I
M
S
N
E
Y
G
V
M
L
N
-----------------
G
N
S
F
A
I
A
A
A
R
I
P
Y
F
L
N
L
K
G
P
A
I
P
I
D
T
A
S
S
S
S
L
V
G
T
H
L
A
R
Q
A
L
I
N
K
E
I
D
M
A
L
V
G
G
V
S
L
Y
L
T
P
E
S
Y
M
S
M
--
A
G
M
L
S
P
D
-
G
Q
C
K
A
F
D
N
G
A
N
G
F
V
P
G
E
G
A
G
A
L
V
L
K
R
L
K
D
A
E
A
D
R
D
H
I
Y
G
I
I
I
G
S
G
I
N
Q
D
G
-
K
-
T
N
G
I
T
A
P
S
A
K
S
Q
M
D
L
E
R
D
I
Y
E
T
Y
G
I
H
P
E
S
I
S
Y
V
E
M
H
G
T
G
T
K
Q
G
D
P
I
E
L
E
A
L
S
T
V
F
Q
E
K
T
D
--
K
K
Q
F
C
A
I
G
S
V
K
S
N
I
G
H
T
S
A
A
A
G
V
A
G
V
Q
K
V
L
L
C
M
N
H
K
T
L
V
P
T
L
N
F
T
T
P
N
E
H
F
E
-
F
E
H
S
P
L
Y
V
N
T
E
L
K
P
W
E
T
A
D
--------
G
K
P
R
R
A
C
V
S
S
F
G
Y
S
G
T
N
A
H
I
V
I
E
E
Y
Q
P
E
--------------
S
A
L
F
V
L
S
A
K
K
E
K
Q
L
K
A
Y
A
E
A
M
K
D
F
V
T
S
N
E--
D
I
D
L
E
D
M
A
Y
T
L
Q
T
G
R
E
A
M
D
Y
R
M
A
F
L
A
D
S
R
E
M
L
I
K
A
-------------------------------------------------------
L
-----------------------------
D
D
Y
------
L
A
----
E
M
P
N
-------------
G
----------------------------------------
S
I
--------
F
A
A
H
----------------------
V
K
-
T
K
-----------------------
K
-----------------------------------
S
E
IKLFETD
H
D
A
K
A
L
L
Q
T
------------------
W
I
E
---------------------
K
K
R
L
E
K
V
A
E
L
W
V
K
G
L
-
Q
I
D
W
N
K
L
Y
G
E
-
Y
-----
T
P
R
R
I
S
L
P
A
Y
P
F
A
E
E
Y
Y
W
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.83
54%
-77
- C2 -
4TKT
6
?
A:
[9-613]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
I
V
G
M
A
G
R
Y
P
G
A
P
D
L
D
T
F
W
E
N
L
L
A
G
R
D
S
I
T
E
I
P
A
G
R
W
D
H
S
R
Y
Y
D
A
R
R
G
V
P
G
R
T
Y
S
K
W
G
G
F
L
D
G
I
D
E
F
D
P
L
F
F
G
I
S
P
K
A
A
S
T
M
D
P
Q
E
R
L
F
L
Q
C
A
H
T
T
L
E
D
A
G
Y
S
R
G
A
L
R
A
A
A
---
R
A
R
V
A
ED
A
G
D
I
G
V
F
A
G
A
M
Y
S
E
Y
Q
--
L
Y
G
A
E
Y
S
V
R
G
-
E
P
V
V
V
-
P
G
S
L
A
S
I
A
N
R
V
S
Y
F
L
D
A
S
G
P
S
V
T
V
D
T
M
C
A
S
A
L
S
A
I
H
L
A
C
A
A
L
Q
R
G
E
C
G
V
A
L
A
G
G
V
N
L
S
V
H
P
G
K
Y
L
M
I
G
E
G
Q
F
A
S
-
S
D
G
R
C
R
S
F
G
E
G
G
D
G
Y
V
P
G
E
G
V
G
A
V
L
L
R
P
L
A
D
A
V
A
D
G
D
R
I
L
G
V
I
R
G
T
A
V
N
H
G
G
H
T
H
G
F
T
V
P
N
P
L
A
Q
A
A
V
I
R
S
A
W
R
R
A
G
V
D
P
R
D
I
G
C
I
E
A
H
G
T
G
T
S
L
G
D
P
I
E
I
A
G
L
N
A
A
F
A
E
F
T
D
---
A
R
-----
N
F
C
A
I
G
S
A
K
S
N
I
G
H
L
E
S
A
A
G
I
A
G
L
A
K
L
L
L
Q
M
R
H
G
T
L
V
P
S
L
H
A
E
R
V
N
P
D
I
D
F
A
D
S
P
F
V
L
Q
R
E
A
A
P
W
P
R
T
G
T
R
---------
P
R
L
G
G
L
S
S
F
G
A
G
G
S
N
A
H
V
V
V
E
D
Y
V
E
---------H
R
G
E
T
V
V
V
V
L
S
A
F
D
E
E
R
L
R
E
S
A
G
R
L
R
D
A
L
R
K
E
R
W
S
S
A
D
L
P
D
I
A
Y
T
L
Q
V
G
R
E
A
M
T
A
R
F
A
V
A
V
S
T
L
P
A
L
V
D
A
L
D
A
C
A
L
G
----
S
G
L
P
A
G
A
Y
F
N
P
G
---------------
F
Q
E
T
A
V
R
W
A
R
R
G
K
P
A
P
L
A
E
A
W
T
S
G
L
A
V
D
W
A
R
L
H
T
-G
P
K
P
R
K
V
A
L
P
G
Y
P
F
A
R
E
R
Y
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
62.74
34%
-59
- C2 -
4KC5
1
?
A:
[8-921]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
L
A
N
Y
I
A
V
I
G
L
G
G
Y
Y
P
G
A
D
S
I
D
E
L
W
Q
N
L
A
N
G
V
D
C
M
S
D
F
P
A
D
R
W
D
H
S
K
I
Y
Y
K
N
R
K
V
L
G
K
T
T
C
I
N
G
S
F
I
K
D
V
D
K
F
D
Y
S
Y
F
K
M
P
K
V
Y
A
D
H
M
S
P
E
V
R
L
F
L
Q
V
A
V
H
T
F
E
D
A
G
Y
S
K
E
T
L
L
S
R
Y
-------
N
---
G
D
V
G
V
L
L
G
T
M
S
N
D
Y
H
--
Y
Y
G
F
E
S
N
V
F
R
-
G
S
M
A
S
-
G
S
G
M
A
T
I
P
M
T
V
S
Y
F
Y
G
L
T
G
P
S
L
F
I
D
T
M
C
S
S
S
S
T
C
I
H
T
A
C
Q
M
L
K
H
D
E
T
K
M
V
L
A
G
G
L
N
L
M
Y
H
P
Y
T
T
V
N
T
S
Q
G
N
F
T
S
I
T
S
E
S
V
N
S
Y
G
V
G
A
D
G
T
V
I
G
E
G
I
G
A
V
L
L
K
R
L
D
R
A
I
A
D
R
D
Q
I
Y
G
V
I
K
G
S
A
M
T
N
A
G
E
R
N
G
F
N
V
P
N
P
D
L
Q
T
L
A
I
R
Q
A
M
D
Q
A
K
V
H
P
S
S
I
S
Y
I
E
G
H
G
S
G
T
K
L
G
D
P
I
E
V
L
G
L
N
N
A
F
R
W
A
T
D
---
D
K
-----
Q
F
C
Y
L
G
S
I
K
S
N
I
G
H
L
L
A
A
S
G
I
A
G
L
T
K
T
L
L
Q
F
K
H
K
Q
I
A
P
S
I
H
S
S
Q
L
N
Q
D
I
D
F
A
D
T
P
F
V
V
P
Q
Q
L
I
E
W
R
Q
P
E
R
I
I
N
G
R
K
-
Q
V
F
P
R
R
A
G
L
T
S
I
A
A
G
G
M
N
A
H
M
I
V
E
E
Y
-
P
E
P
A
D
S
A
G
Q
I
-
S
E
D
Q
L
V
F
V
F
S
V
H
K
L
A
L
L
A
Q
N
L
T
S
F
R
D
W
L
A
S
S
---
E
A
P
L
A
Q
I
A
Y
T
L
Q
V
G
K
N
N
L
R
N
R
L
A
I
R
C
R
T
R
Q
A
L
S
R
A
L
N
A
C
I
D
G
HYQS
S
A
D
S
K
I
F
Y
R
F
Q
E
S
D
A
V
Q
P
L
E
S
D
L
N
D
P
-
L
A
P
L
L
T
Q
W
L
N
G
D
S
------------
Q
V
D
W
A
S
L
Y
A
--
Q
P
P
V
R
I
S
L
P
A
Y
R
F
E
K
T
R
C
W
Y
T
E
E
G
Y
E
S
S
I
V
N
P
L
M
F
K
N
K
----
L
H
P
L
V
A
K
N
C
S
T
P
Q
P
G
A
I
F
R
T
D
F
V
E
D
E
L
L
D
Y
V
Y
S
G
R
G
G
R
R
L
S
A
F
N
F
A
D
V
A
L
A
M
P
A
L
A
S
R
F
D
G
R
T
L
S
V
S
C
A
F
E
H
Y
IA
D
W
T
T
V
T
G
L
E
Y
R
L
F
E
I
D
S
E
Q
L
E
L
E
F
D
F
R
R
S
G
E
Q
P
T
H
L
G
F
A
V
I
N
P
L
T
SDEPPLP
Q
Q
W
L
D
D
A
R
E
L
L
N
R
Q
A
L
Q
A
G
R
Q
L
S
A
A
E
V
S
Q
R
L
A
Q
A
G
Y
D
F
A
P
Y
L
D
H
D
G
E
L
T
I
G
R
S
G
L
V
L
K
G
R
P
P
V
N
R
H
N
H
Y
A
D
N
V
Q
-
L
S
P
Y
L
A
T
T
I
D
K
A
L
Y
L
L
L
D
E
L
G
L
P
Q
G
--
R
V
I
V
R
N
I
E
R
L
C
C
Y
H
--
T
P
A
G
G
F
S
V
V
L
S
G
I
G
L
N
D
N
E
L
S
L
S
L
L
V
L
D
E
R
E
-
Q
I
C
V
K
L
D
K
V
S
L
Y
L
G
K
Q
E
V
A
S
V
D
R
K
H
S
L
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
62.52
49%
-71
- C2 -
4OPE
-
?
A:
[6-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
E
I
V
I
V
G
V
A
G
R
Y
P
K
A
D
D
L
A
Q
F
W
R
N
L
R
E
G
R
D
C
V
E
E
V
P
E
D
R
W
D
H
G
R
F
Y
D
P
D
P
A
A
P
G
K
A
Y
A
K
W
G
G
W
L
S
D
V
A
S
F
D
P
M
F
F
R
M
S
Q
V
E
A
E
H
I
D
P
Q
E
R
I
F
L
Q
T
V
W
H
L
L
E
D
A
G
T
S
R
A
A
L
S
----------
K
---
V
R
T
G
V
F
V
G
L
M
Y
G
H
Y
Q
--
L
Y
G
V
E
E
A
L
R
G
-
T
G
A
A
T
-
S
S
S
Y
A
S
V
A
N
R
V
S
Y
F
F
D
F
D
G
P
S
I
A
L
D
T
M
C
S
S
S
L
T
A
L
H
L
A
C
R
A
I
R
D
G
D
C
E
V
A
V
A
G
G
V
N
V
S
S
H
P
L
K
Y
L
Q
L
A
K
G
G
F
L
S
-
T
D
G
R
C
R
S
F
G
E
G
G
D
G
Y
V
P
A
E
G
S
G
A
V
L
L
K
R
R
S
A
A
E
A
D
G
D
R
V
L
A
V
V
R
S
T
A
V
N
H
G
G
A
G
K
G
F
S
V
P
N
P
R
A
Q
G
V
L
I
G
E
A
L
E
R
A
G
L
A
P
A
D
L
G
Y
L
E
A
H
G
T
G
T
S
L
G
D
P
V
E
I
T
G
L
V
R
A
F
Q
G
H
D
L
---
T
G
-----
V
R
I
P
I
G
S
V
K
S
G
I
G
H
A
E
S
A
A
G
M
A
A
L
T
K
V
L
L
Q
F
R
H
Q
E
L
V
P
S
L
H
A
E
R
L
N
P
H
L
D
L
D
A
T
P
F
R
L
Q
R
D
L
A
P
W
T
P
R
V
D
---
A
T
G
-
R
A
L
P
R
T
A
A
I
S
A
F
G
A
G
G
S
N
A
H
V
I
L
E
E
S
V
P
P
T
Q
T
---
P
A
-
Q
E
P
P
Y
V
C
A
L
S
A
R
D
A
E
R
L
H
E
H
T
A
R
T
A
E
F
L
R
G
E
G
-
R
A
A
H
P
A
A
V
A
A
T
L
L
-
T
R
E
P
M
A
H
R
L
A
V
V
F
D
T
V
D
D
L
A
D
A
L
E
D
H
L
A
G
----
A
G
S
P
-
R
V
L
T
G
T
A
S
R
-----------------
A
A
A
P
A
T
G
R
T
A
P
E
L
A
E
A
W
V
R
G
A
P
V
A
A
P
A
------
G
A
P
R
V
S
L
P
G
Y
P
F
A
R
E
R
C
W
L
P
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
61.05
53%
-55
- C2 -
5ERB
-
?
A:
[6-615]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
D
I
A
I
I
G
I
S
G
R
Y
P
Q
A
E
N
L
Q
E
F
W
K
N
L
S
E
G
T
D
C
I
T
E
I
P
N
D
R
W
D
H
S
L
Y
Y
D
A
-
D
K
D
K
E
G
K
T
Y
G
K
W
G
G
F
L
K
D
V
D
K
F
D
P
Q
F
F
S
I
S
P
R
D
A
K
L
M
D
P
Q
E
R
L
F
L
Q
C
V
Y
E
T
M
E
D
A
G
Y
T
R
K
K
L
T
E
K
S
G
---
D
L
L
G
A
N
V
G
V
Y
V
G
V
M
Y
E
E
Y
Q
L
Y
G
A
E
E
Q
-----
A
R
-------
T
G
N
P
S
S
I
A
N
R
A
S
Y
V
F
G
F
N
G
P
S
M
A
L
D
T
M
C
S
S
S
L
T
A
I
H
L
A
C
Q
S
L
R
N
G
E
C
E
A
A
F
A
G
G
V
N
V
S
V
H
P
N
K
Y
L
M
L
G
Q
N
R
F
L
S
S
K
-
G
R
C
E
S
F
G
E
G
G
D
G
Y
V
P
G
E
G
V
G
A
V
L
L
K
P
L
S
K
A
K
A
D
G
D
H
I
Y
G
L
I
K
G
T
A
V
N
H
D
G
-
K
-
T
N
G
Y
S
V
P
N
P
N
A
Q
A
A
V
I
K
Q
A
L
K
D
A
G
T
D
P
R
A
V
S
Y
I
E
A
H
G
T
G
T
S
L
G
D
P
I
E
I
T
G
L
T
K
A
F
S
E
Q
T
Q
----
Q
F
C
A
I
G
S
A
K
S
N
I
G
H
C
E
S
A
A
G
I
A
G
L
T
K
V
L
L
Q
M
K
H
K
Q
L
A
P
S
L
H
S
R
T
L
N
P
N
I
D
-
F
L
A
T
P
F
K
V
Q
Q
T
L
E
E
W
K
R
P
V
I
N
E
N
-----
L
P
R
T
A
G
L
S
S
F
G
A
G
G
V
N
A
H
I
V
I
E
E
Y
S
--------------
P
H
P
S
M
I
V
L
S
A
K
N
E
Q
R
L
Q
K
R
A
K
R
L
L
D
A
L
R
S
GRYR
E
A
D
L
S
R
I
A
Y
T
L
Q
V
G
R
E
P
M
E
E
R
L
G
M
I
V
S
N
L
R
E
L
E
E
K
-------------------------------------------------------
L
-----------------------------
D
E
F
------
T
G
----
G
K
E
S
-------------
I
------------------------------
D
---------
Q
L
--------
Y
R
G
Q
-------------------------
Q
N
-----------------------
K
-----------------------------------
D
T
M
A
L
F
T
AD
E
D
M
E
K
T
I
E
A
------------------
W
L
E
---------------------
K
G
K
A
A
K
V
L
E
L
W
V
K
G
L
-
P
L
N
W
D
K
L
Y
Q
M
-
G
-----
R
P
Q
K
I
S
L
P
A
Y
P
F
A
K
D
R
Y
W
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
60.94
25%
-71
- C2 -
2QO3
3
ERYA2_SACER
A:
[4-883]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
D
P
I
A
I
V
S
M
A
C
R
L
P
G
G
V
N
T
P
Q
R
L
W
E
L
L
R
E
G
G
E
T
L
S
G
F
P
T
D
R
G
W
D
L
A
R
L
H
H
P
D
P
D
N
P
G
T
S
Y
V
D
K
G
G
F
L
D
D
A
A
G
F
D
A
E
F
F
G
V
S
P
R
E
A
A
A
M
D
P
Q
Q
R
L
L
L
E
T
S
W
E
L
V
E
N
A
G
I
D
P
H
S
L
R
G
T
A
T
G
V
F
L
G
V
A
K
F
G
Y
G
E
D
T
A
D
V
E
G
Y
S
V
T
G
V
A
P
A
V
A
S
G
R
I
S
Y
T
M
G
L
E
G
P
S
I
S
V
D
T
A
C
S
S
S
L
V
A
L
H
L
A
V
E
S
L
R
K
G
E
S
S
M
A
V
V
G
G
A
A
V
M
A
T
P
G
V
F
V
D
F
S
R
Q
R
A
L
A
A
D
G
R
S
K
A
F
G
A
G
A
D
G
F
G
F
S
E
G
V
T
L
V
L
L
E
R
L
S
E
A
R
R
N
G
H
E
V
L
A
V
V
R
G
S
A
L
N
Q
D
G
A
S
N
G
L
S
A
P
S
G
P
A
Q
R
R
V
I
R
Q
A
L
E
S
C
G
L
E
P
G
D
V
D
A
V
E
A
H
G
T
G
T
A
L
G
D
P
I
E
A
N
A
L
L
D
T
Y
G
R
D
R
D
A
D
R
P
L
W
L
G
S
V
K
S
N
I
G
H
T
Q
A
A
A
G
V
T
G
L
L
K
V
V
L
A
L
R
N
G
E
L
P
A
T
L
H
V
E
E
P
T
P
H
V
D
W
S
S
G
G
V
A
L
L
A
G
N
Q
P
W
R
-
R
G
E
R
T
R
R
A
A
V
S
A
F
G
I
S
G
T
N
A
H
V
I
V
E
E
A
P
E
H
D
G
R
--------
P
V
P
L
V
V
S
A
R
S
T
A
A
L
R
A
Q
A
A
Q
I
A
E
L
L
-
E
R
P
D
A
D
L
A
G
V
G
L
G
L
A
T
T
R
A
R
H
E
H
R
A
A
V
V
A
S
T
R
E
E
A
V
R
G
L
R
E
I
A
A
G
A
A
T
A
D
A
V
V
E
G
V
T
E
V
D
G
R
N
V
V
F
L
F
P
G
Q
GS
Q
W
A
G
M
G
A
E
L
L
S
S
S
P
V
F
A
G
K
I
R
A
C
D
E
S
M
A
P
M
Q
D
W
K
V
S
D
V
L
R
Q
A
P
G
A
P
------
G
L
D
R
V
D
V
V
Q
P
V
L
F
A
V
M
V
S
L
A
E
L
W
R
S
Y
G
V
E
P
A
A
V
V
G
H
S
Q
G
E
I
A
A
A
H
V
A
G
A
L
T
L
E
D
A
A
K
L
V
V
G
R
S
R
L
M
R
S
L
S
G
E
G
G
M
A
A
V
A
L
G
E
A
A
V
R
E
R
L
R
P
W
Q
D
R
L
S
V
A
A
V
N
---
G
P
R
S
V
V
V
S
G
E
P
G
A
L
R
A
F
S
E
D
C
A
A
E
G
I
R
V
R
D
I
D
V
D
Y
A
S
H
S
P
Q
I
E
R
V
R
E
E
L
L
E
T
T
G
D
I
A
P
R
P
A
R
V
T
F
H
S
T
V
E
S
R
S
M
D
G
T
-
E
L
D
A
R
Y
W
Y
R
N
L
R
E
T
V
R
F
A
D
A
V
T
R
L
A
E
S
G
Y
D
A
F
I
E
V
S
P
H
P
V
V
V
Q
A
V
E
E
A
V
E
E
A
D
G
A
E
D
A
V
V
V
G
S
L
HRDG
G
D
L
S
A
F
L
R
S
M
A
T
A
H
V
S
G
V
D
I
R
W
D
V
A
L
P
G
A
A
P
F
A
L
P
T
Y
P
F
Q
R
K
R
Y
W
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
50.69
39%
-76
- C2 -
4OQJ
3
?
A:
[18-532]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
D
S
D
I
A
V
I
G
L
A
C
R
F
P
G
A
A
T
P
D
T
F
W
K
V
L
S
E
G
R
E
T
L
T
H
F
S
D
E
E
L
R
A
A
G
V
A
E
--
P
-
L
L
A
D
D
R
Y
V
K
A
G
Q
V
L
V
D
A
D
K
F
D
A
G
L
F
G
I
T
R
D
E
A
E
L
I
D
P
Q
Q
R
Q
F
L
E
C
A
Y
E
A
L
E
R
A
G
Y
D
P
Q
R
G
E
-----------
Q
R
I
G
V
Y
A
G
V
G
L
N
T
Y
L
L
H
N
L
G
E
R
Y
R
T
AS
S
V
D
R
Y
R
M
M
I
T
N
D
K
D
F
V
A
T
R
T
A
Y
K
L
N
L
C
G
P
S
V
S
T
N
T
A
C
S
T
S
L
V
A
V
H
L
A
C
L
S
L
L
S
G
D
C
T
M
A
L
A
G
A
A
H
I
Q
A
D
Q
G
E
G
Y
L
H
H
E
G
M
I
F
S
P
D
-
G
H
C
R
A
F
D
A
K
A
Q
G
T
V
I
G
N
G
V
G
A
V
V
L
K
R
L
S
D
A
L
A
D
G
D
T
V
H
A
V
I
K
G
T
A
V
N
N
D
G
-
S
D
K
T
G
Y
T
A
P
S
V
Q
G
Q
A
A
V
V
A
E
A
Q
E
I
A
D
V
G
P
E
T
V
S
Y
V
E
A
H
G
T
A
T
P
L
G
D
P
I
E
V
A
A
L
N
Q
A
F
N
R
E
G
A
AL
A
P
G
S
C
A
L
G
S
V
K
T
N
V
G
H
L
D
T
A
A
G
M
A
G
L
I
K
T
I
L
M
L
R
H
R
T
L
V
P
S
L
C
F
E
A
P
N
P
E
I
D
-
F
A
A
G
P
F
Y
V
G
T
E
T
K
E
W
P
A
G
---------
P
T
P
R
R
A
G
V
S
S
F
G
I
G
G
T
N
A
H
V
I
V
E
E
P
P
A
V
------------
A
G
P
R
L
L
V
L
S
A
N
T
P
A
A
L
D
T
A
T
A
D
L
A
R
A
L
R
K
D
R--
D
L
D
L
S
A
V
A
Q
T
L
A
L
G
R
R
V
L
P
Y
R
R
A
L
V
A
T
G
V
R
D
A
A
L
A
-------------------------------------------------------
L
-----------------------------
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------