@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18090: (2016-06-28 )
MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVYEIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKIGKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVFYYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAREEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEESNILENENLSVAEEV
Atome Classification :
(48 SA)
.........10...-.....20........30...-.-.-...40........50........60--.........-70........80...-..-..-.90........100.......110...-------....120.......130.......140.......150.........160--.--.---.--....170.-------......-180-..-......190.......200.......210--.----.--------------.....220.......230...-...-.-240-.........250.......260.-.....-.270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARKQQFDY
N
E
D
A
I
-
Q
V
L
E
G
L
E
A
V
R
KRP
G
M
Y
IGST-D-A-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
AGHG
D
---
H
I
I
V
K
I
HKD-
N
S
I
S
V
QDRGRGMPT
G
-
M
H
-KL-GKP
T
P
E
V
I
L
T
V
L
HAGGKFGQGGYKTSG-------GLH
G
V
G
A
S
V
V
N
A
L
S
E
W
L
T
V
T
I
ERDG
F
V
Y
Q
Q
R
F
ENG--GK
P
V
T
S
L
E
K
IGK--T--K---K--T
G
T
L
THFK-------PDP
T
M
F
-
S
-
T
-
T
T-Y
N
F
E
T
L
S
E
R
L
R
E
S
A
F
L
LKG
L
K
I
E
L
I
DERN--D----Q--------------
R
E
V
F
Y
YEN
G
I
E
A
F
V
A
Y
LNE
E
K
-
D
V
L
-
S
-
E
---
V
V
S
FEGEH
H
S
I
E
V
D
F
A
F
Q
FNDGY-
S
E
N
I
L
-
S
F
V
N
N
VRTKDGGTHESG
A
K
T
A
M
T
R
A
F
N
E
Y
A
R
K
V
A
L
L
K
EKDKNLEG
T
D
I
R
E
G
L
S
A
I
I
SVRI
P
E
E
L
L
Q
FEGQTKGKLG
T
S
E
A
R
S
A
V
D
A
I
V
S
E
Q
L
A
Y
F
L
E
ENR
D
T
A
T
L
L
V
K
K
A
I
K
A
S
Q
A
R
E
A
A
R
K
A
R
E
E
A
RSGKKRKKSEATLSGKLTPAGSRNPAKN
E
L
Y
L
V
EGDSAGGSAKQGRDR
R
F
Q
A
VLPLR
G
K
VIN
T
E
K
A
K
L
A
D
I
F
KNE
E
I
N
T
I
I
H
A
IGGGVGAD
F
S
IDDINY
D
K
I
I
I
M
TDADTDG
A
H
I
Q
V
L
L
L
T
F
F
Y
R
Y
M
K
P
L
I
EHG
K
V
F
I
ALPP
L
Y
K
VSKGS
G
K
K
E
I
I
E
YAWS
D
E
E
M
G
D
V
L
K
KVGKG
Y
T
I
Q
R
Y
KGLGEM
N
A
D
Q
L
W
E
TTMNPES
R
T
L
V
R
V
KID
D
A
A
R
V
E
R
R
V
T
T
L
MGDK
V
E
P
R
R
K
W
I
E
K
NVAFGLDEESNILENENLSVAEEV
1
PsiBlast_PDB
79.05
71%
19
- C4 -
4JUO
4
PARE_STRPN
C:
[47-663]
----------------------
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
---
D
---
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
-----------------
T
V
E
V
I
F
T
I
L
H
A
G
G
K
F
-----------------
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
--
G
K
P
V
T
T
L
K
K
I
G
T
--
A
PK
S
---
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
-
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
--
D
----
E
--------------
A
I
E
F
H
Y
E
--
V
Q
D
F
V
S
Y
L
N
E
D
K
-
E
I
L
-
T
-
P
---
V
L
Y
F
E
G
E
D
N
G
F
Q
V
E
V
A
L
Q
Y
N
D
G
F
-
S
D
N
I
L
-
S
F
V
N
N
V
R
T
K
D
G
G
T
H
E
T
G
L
K
S
A
I
T
K
V
M
N
D
Y
A
R
K
T
G
L
L
K
E
K
----
E
G
S
D
Y
R
E
G
L
A
A
V
L
S
I
L
V
P
E
E
H
L
Q
F
E
G
Q
T
K
D
K
L
G
S
P
L
A
R
P
V
V
D
G
I
V
A
D
K
L
T
F
F
L
M
E
N
G
E
L
A
S
N
L
I
R
K
A
I
K
A
R
D
A
R
E
A
A
R
K
A
R
-------------------
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
-
P
P
L
Y
K
-----------
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
-------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-------------------
35
PsiBlast_CBE
62.45
46%
-17
- C3 -
3ZKD
3
GYRB_MYCTU
H:
[17-426]
--------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
--
T
----
Q
K
V
K
-----------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
61.89
46%
-21
- C3 -
3ZKD
3
GYRB_MYCTU
F:
[15-426]
------
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
--
T
-----K
V
K
-----------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
------
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
61.54
46%
-9
- C3 -
3ZKD
3
GYRB_MYCTU
C:
[17-426]
--------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
--
T
----
Q
DE
R
A
A
E
S
T
APHK
V
K
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
--
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
60.72
51%
-7
- C3 -
3ZKB
3
GYRB_MYCTU
A:
[16-428]
-------
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
---
S
E
P
L
G
L
K
-
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
----PHK
V
K
--------------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
-
H
S
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
---
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
60.54
46%
-16
- C3 -
3ZKD
3
GYRB_MYCTU
D:
[16-428]
-------
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
--------K
V
K
-----------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
---
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
60.39
46%
5
- C3 -
3ZKB
3
GYRB_MYCTU
D:
[12-427]
---
K
A
Q
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
--
T
----
Q
STAPHK
V
K
------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
60.31
46%
-6
- C3 -
3ZKB
4
GYRB_MYCTU
B:
[15-429]
------
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
---------VK------------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
D
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
59.91
77%
-107
- C4 -
3RAE
5
D:
[36-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
-----------
Y
A
W
T
D
G
E
L
E
E
L
R
K
Q
------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-------------------
15
PsiBlast_PDB
59.38
46%
-3
- C3 -
3ZKD
3
GYRB_MYCTU
A:
[17-429]
--------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
---------HKVK----------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
-----
K
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
58.72
79%
-103
- C4 -
3K9F
5
PARE_STRPN
C:
[36-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
--
D
F
S
I
E
-
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
S
K
-
K
G
K
K
E
E
V
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
Q
F
G
K
G
A
T
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-------------------
24
PsiBlast_CBE
58.59
77%
-104
- C4 -
3RAF
5
D:
[36-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
----------
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
Q
------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-------------------
10
PsiBlast_PDB
58.55
77%
-107
- C4 -
3RAE
5
PARE_STRPN
C:
[35-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
------------
Y
A
W
T
D
G
E
L
E
E
L
R
K
-------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-------------------
4
PsiBlast_PDB
58.46
77%
-103
- C4 -
3K9F
5
PARE_STRPN
C:
[36-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
--
D
F
S
I
E
-
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
S
K
-
K
G
K
K
E
E
V
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
Q
F
G
K
G
A
T
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-------------------
41
PsiBlast_CBE
58.41
46%
-5
- C3 -
3ZKD
3
GYRB_MYCTU
B:
[17-425]
--------
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
--------H
K
V
K
----------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
----
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
58.26
77%
-103
- C4 -
3K9F
5
D:
[36-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
--
D
F
S
I
E
-
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
S
K
-
K
G
K
K
E
E
V
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
Q
F
G
K
G
A
T
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-------------------
21
PsiBlast_CBE
58.26
77%
-108
- C4 -
4KPF
5
D:
[36-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
M
----------
A
Y
A
W
T
D
G
E
L
E
E
L
R
K
Q
------
L
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-------------------
34
PsiBlast_CBE
58.22
46%
-24
- C3 -
3ZM7
2
GYRB_MYCTU
C:
[36-436]
-------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
--------------------------
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
---------KV
K
-----------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
K
--
D
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
--
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
58.17
77%
-101
- C4 -
4KOE
5
D:
[36-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
P
A
Q
S
K
N
P
A
K
N
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
R
D
R
K
F
Q
A
I
L
P
L
R
G
K
V
I
N
T
A
K
A
K
M
A
D
I
L
K
N
E
E
I
N
T
M
I
Y
T
I
G
A
G
V
G
A
D
F
S
I
E
D
A
N
Y
D
K
I
I
I
M
T
D
A
D
T
D
G
A
H
I
Q
T
L
L
L
T
F
F
Y
R
Y
M
R
P
L
V
E
A
G
H
V
Y
I
A
L
P
P
L
Y
K
------------
Y
A
W
T
D
G
E
L
E
E
L
R
K
Q
-------
Q
R
Y
K
G
L
G
E
M
N
A
D
Q
L
W
E
T
T
M
N
P
E
T
R
T
L
I
R
V
T
I
E
D
L
A
R
A
E
R
R
V
N
V
L
M
G
D
K
V
E
P
R
R
K
W
I
E
D
N
V
K
F
T
-------------------
36
PsiBlast_CBE
58.04
46%
16
- C3 -
3ZKD
3
GYRB_MYCTU
G:
[15-425]
------
D
E
Y
G
A
A
S
I
-
T
I
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
Y
A
T
---
T
V
N
V
V
L
L
E
D
-
G
G
V
E
V
A
D
D
G
R
G
I
P
V
A
-
T
H
-
A
S
-
G
I
P
T
V
D
V
V
M
T
Q
L
H
A
G
G
K
F
D
S
D
A
Y
A
I
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
V
E
I
K
R
D
G
Y
E
W
S
Q
V
Y
E
K
S
---
E
P
L
-
G
L
K
Q
G
A
P
--
T
--
K
---
K
--
T
G
S
T
V
R
F
W
-------
A
D
P
A
V
F
-
E
-
T
-
T
E
-
Y
D
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
N
L
T
D
E
R
V
--------PHK
V
K
---------
S
R
T
F
H
Y
P
G
G
L
V
D
F
V
K
H
I
N
R
T
K
-
N
A
I
H
S
-
S
---
I
V
D
F
S
G
K
G
T
G
H
E
V
E
I
A
M
Q
W
N
A
G
Y
-
S
E
S
V
H
-
T
F
A
N
T
I
N
T
H
E
G
G
T
H
E
E
G
F
R
S
A
L
T
S
V
V
N
K
Y
A
K
D
R
K
L
L
----
P
N
L
T
G
D
D
I
R
E
G
L
A
A
V
I
S
V
K
V
S
E
P
--
Q
F
E
G
Q
T
K
T
K
L
G
N
T
E
V
K
S
F
V
Q
K
V
C
N
E
Q
L
T
H
W
F
E
A
N
P
T
D
A
K
V
V
V
N
K
A
V
S
S
A
Q
A
R
I
A
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
57.42
51%
18
- C3 -
4WUB
5
GYRB_ECOLI
A:
[3-390]
-------
S
Y
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
-
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
---
G
V
P
Q
A
P
L
A
V
T
G
E
--
T
--
E
---
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
-
N
V
T
E
-
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
--
G
----
K
--------------
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
-
T
P
I
-
H
P
N
---
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
-----
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Fugue
57.42
50%
20
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
-----
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
-
D
G
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
E
-
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
P
L
A
V
T
G
E
--
T
--
E
---
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
N
V
-
T
E
-
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
--
G
----
K
--------------
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
-
T
P
I
H
P
-
N
---
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
--
P
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Fugue
56.33
50%
33
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
-----
S
N
S
S
D
S
S
S
I
-
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
D
D
-
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
E
-
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
Y
K
V
S
G
-------
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
P
L
A
V
T
G
E
--
T
---E--
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
N
V
-
T
E
-
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
K
R
D
--
G
----
K
--------------
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
-
T
P
I
H
P
-
N
---
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
--
P
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
M
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
55.60
48%
22
- C3 -
1KIJ
3
GYRB_THET8
A:
[7-388]
------------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
---
E
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
-
L
M
-
P
E
E
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
R
---
G
E
V
T
E
P
L
R
V
V
G
E
AP
R
--
G
---
K
--
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
-
N
-
L
R
-
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
--
G
----
K
--------------
E
E
V
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
-
D
L
L
-
Y
E
K
---
P
F
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
L
-
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
A
L
R
A
A
Q
A
R
E
A
A
R
K
A
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
55.19
46%
19
- C3 -
1KIJ
3
GYRB_THET8
B:
[7-372]
------------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
---
E
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
-
E
E
-
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
R
---
G
E
V
T
E
P
L
R
V
V
G
E
--
A
--
P
RG-
K
--
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
-
N
-
L
R
-
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
--
G
----
K
--------------
E
E
V
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
-
D
L
L
-
Y
-
E
K--
P
F
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
L
-
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
54.31
46%
19
- C3 -
1KIJ
3
GYRB_THET8
A:
[7-372]
------------
A
I
-
R
V
L
K
G
L
E
G
V
R
H
R
P
A
M
Y
I
G
G
T
-
G
-
V
-
E
G
Y
H
H
L
F
K
E
I
L
D
N
A
V
D
E
A
L
A
G
Y
A
T
---
E
I
L
V
R
L
N
E
D
-
G
S
L
T
V
E
D
N
G
R
G
I
P
V
D
L
M
P
-
E
E
-
G
K
P
A
V
E
V
I
Y
N
T
L
H
S
G
G
K
F
E
Q
G
A
Y
K
V
S
G
-------
G
L
H
G
V
G
A
S
V
V
N
A
L
S
E
W
T
V
V
E
V
F
R
E
G
K
H
H
R
I
A
F
S
R
---
G
E
V
T
E
P
L
R
V
V
G
E
--
A
--
P
RG-
K
--
T
G
T
R
V
T
F
K
-------
P
D
P
E
I
F
-
G
-
N
-
L
R
-
F
D
P
S
K
I
R
A
R
L
R
E
V
A
Y
L
V
A
G
L
K
L
V
F
Q
D
R
Q
H
--
G
----
K
--------------
E
E
V
F
L
D
K
G
G
V
A
S
F
A
K
A
L
A
E
G
E
-
D
L
L
-
Y
-
E
K
--
P
F
L
I
R
G
T
H
G
E
V
E
V
E
V
G
F
L
H
T
Q
G
Y
-
N
A
E
I
L
-
T
Y
A
N
M
I
P
T
R
D
G
G
T
H
L
T
A
F
K
S
A
Y
S
R
A
L
N
Q
Y
A
K
K
A
G
L
N
K
E
K
G
P
Q
P
T
G
D
D
L
L
E
G
L
Y
A
V
V
S
V
K
L
P
N
P
--
Q
F
E
G
Q
T
K
G
K
L
L
N
P
E
A
G
T
A
V
G
Q
V
V
Y
E
R
L
L
E
I
L
E
E
N
P
R
I
A
K
A
V
Y
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
53.34
50%
10
- C3 -
4ZVI
3
GYRB_ECOLI
A:
[1-361]
--------------------
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
E
-
G
V
S
A
A
E
V
I
M
T
V
L
--------------------------
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
-
G
K
I
H
R
Q
I
Y
E
H
G
---
V
P
Q
A
P
L
A
V
T
G
E
--
T
--
E
---
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
-
N
-
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
--
G
----
K
--------------
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
L
N
K
N
K
T
P
I
H
-
P
-
N
---
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
D
G
F
-
Q
E
N
I
Y
-
C
F
T
N
N
I
P
Q
R
D
G
G
T
H
L
A
G
F
R
A
A
M
T
R
T
L
N
A
Y
M
D
K
E
G
Y
S
K
K
A
K
V
S
A
T
G
D
D
A
R
E
G
L
I
A
V
V
S
V
K
V
P
D
P
--
K
F
S
S
Q
T
K
D
K
L
V
S
S
E
V
K
S
A
V
E
Q
Q
M
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
50.91
39%
28
- C3 -
1S16
4
PARE_ECOLI
B:
[5-383]
--------
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
---
T
-
D
-
T
-
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
---
R
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
-
I
H
P
E
E
-
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
--
E
K
-
V
Q
D
L
Q
V
V
G
T
--
C
--
G
---
K
RN
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
-
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
--
N
----
T
--------------
E
Q
R
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
-
P
T
L
-
P
-
E
KPF
I
G
N
F
A
G
D
T
E
A
--
V
D
W
A
L
L
W
L
P
E
G
-
G
E
L
L
T
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
G
V
K
-
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
50.83
39%
30
- C3 -
1S16
4
PARE_ECOLI
A:
[5-383]
--------
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
---
T
-
D
-
T
-
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
---
R
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
-
I
H
P
E
E
-
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
G
--
E
K
-
V
Q
D
L
Q
V
V
G
T
--
C
--
G
---
K
R
N
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
-
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
--
N
----
T
--------------
E
Q
R
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
-
P
T
L
-
P
-
E
K
P
F
I
G
N
F
A
G
D
T
E
A
--
V
D
W
A
L
L
W
L
P
E
G
-
G
E
L
L
T
E
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
G
V
K
-
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
50.59
38%
24
- C3 -
1S16
4
PARE_ECOLI
A:
[4-383]
-------
T
Y
N
A
D
A
I
-
E
V
L
T
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
------
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
---
R
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
-
I
H
-
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
H
A
G
G
K
F
S
N
K
N
Y
Q
F
S
G
-------
G
L
H
G
V
G
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
---
G
E
K
V
Q
D
L
Q
V
V
G
T
CG
K
--
R
---
N
--
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
-
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
--
N
----
T
--------------
E
Q
R
W
C
Y
Q
D
G
L
N
D
Y
L
A
E
A
V
N
G
L
-
P
T
L
-
P
E
K
---
P
F
I
G
N
F
A
G
D
T
E
A
V
D
W
A
L
L
W
L
P
E
G
G
E
L
L
T
E
-
S
Y
V
N
L
I
P
T
M
Q
G
G
T
H
V
N
G
L
R
Q
G
L
L
D
A
M
R
E
F
C
E
Y
R
N
I
L
P
R
-
G
V
K
L
S
A
E
D
I
W
D
R
C
A
Y
V
L
S
V
K
M
Q
D
P
--
Q
F
A
G
Q
T
K
E
R
L
S
S
R
Q
C
A
A
F
V
S
G
V
V
K
D
A
F
I
L
W
L
N
Q
N
V
Q
A
A
E
L
L
A
E
M
A
I
S
S
A
Q
R
R
M
R
A
--
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
50.25
70%
-34
- C3 -
4MB9
2
?
A:
[17-226]
---------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
G
-------------------
G
L
H
G
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
--
G
K
P
V
T
T
L
K
K
I
G
T
--
A
LK
S
---
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
-
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
--
D
----
E
--------------
A
I
E
F
H
Y
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
49.21
70%
-31
- C3 -
4LPB
1
?
A:
[17-226]
---------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
--
G
K
P
V
T
T
L
K
K
I
G
T
--
A
LK
S
---
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
-
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
--
D
----
E
--------------
A
I
E
F
H
Y
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
48.60
70%
-32
- C3 -
4EM7
1
?
A:
[17-226]
---------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
--
G
K
P
V
T
T
L
K
K
I
G
T
--
A
LK
S
---
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
-
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
--
D
----
E
--------------
A
I
E
F
H
Y
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
48.27
70%
-31
- C3 -
5BOD
1
?
A:
[17-226]
---------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
G
-------------------------
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
--
G
K
P
V
T
T
L
K
K
I
G
T
--
A
LK
S
---
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
-
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
--
D
----
E
--------------
A
I
E
F
H
Y
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
47.61
70%
-31
- C3 -
4MOT
1
?
A:
[17-226]
---------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
--
G
K
P
V
T
T
L
K
K
I
G
T
--
A
LK
S
---
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
-
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
--
D
----
E
--------------
A
I
E
F
H
Y
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
47.55
70%
-30
- C3 -
4MBC
1
?
A:
[17-226]
---------------
Q
V
L
E
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
G
-
A
G
L
H
H
L
V
W
E
I
V
D
N
A
V
D
E
A
L
S
G
F
G
D
---
R
I
D
V
T
I
N
K
D
-
G
S
L
T
V
Q
D
H
G
R
G
M
P
T
G
-
M
H
-
A
M
-
G
I
P
T
V
E
V
I
F
T
I
L
H
A
------------------------
V
G
S
S
V
V
N
A
L
S
S
W
L
E
V
E
I
T
R
D
G
A
V
Y
K
Q
R
F
E
N
G
--
G
K
P
V
T
T
L
K
K
I
G
T
--
A
LK
S
---
K
--
T
G
T
K
V
T
F
M
-------
P
D
A
T
I
F
-
S
-
T
-
T
D
-
F
K
Y
N
T
I
S
E
R
L
N
E
S
A
F
L
L
K
N
V
T
L
S
L
T
D
K
R
T
--
D
----
E
--------------
A
I
E
F
H
Y
E
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
46.36
57%
-44
- C3 -
4BAE
2
GYRB_MYCS2
B:
[4-203]
-------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
G
-
E
-
R
G
L
H
H
L
I
W
E
V
V
D
N
A
V
D
E
A
M
A
G
F
A
T
---
R
V
D
V
K
I
H
A
D
-
G
S
V
E
V
R
D
D
G
R
G
I
P
V
E
-
M
H
-
A
T
-
G
M
P
T
I
D
V
V
M
T
Q
L
-------------------------
G
V
G
V
S
V
V
N
A
L
S
T
R
L
E
A
T
V
L
R
D
G
Y
E
W
F
Q
Y
Y
D
R
S
VP
G
K
----
L
K
Q
G
G
E
--
T
--
K
---
E
--
T
G
T
T
I
R
F
W
-------
A
D
P
E
I
F
-
E
-
T
-
T
D
-
Y
N
F
E
T
V
A
R
R
L
Q
E
M
A
F
L
N
K
G
L
T
I
E
L
T
D
E
R
D
--
G
----
K
--------------
H
R
V
F
H
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
46.00
71%
-22
- C3 -
4URN
1
?
C:
[19-224]
-------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
N
---
E
I
D
V
T
I
N
K
D
-
G
S
I
S
I
E
D
N
G
R
G
M
P
T
G
-
I
H
-
K
S
-
G
K
P
T
V
E
V
I
F
T
V
L
---------------------------
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
N
I
Y
H
Q
S
F
K
N
G
--
G
S
P
S
S
G
L
V
K
K
G
K
--
T
--
K
---
K
--
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
K
A
-
S
-
T
S
-
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
S
GK
E
----
R
--------------
Q
E
H
Y
H
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
45.85
71%
-30
- C3 -
4URN
1
?
A:
[17-223]
-----------------
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
N
---
E
I
D
V
T
I
N
K
D
-
G
S
I
S
I
E
D
N
G
R
G
M
P
T
G
-
I
H
-
K
S
-
G
K
P
T
V
E
V
I
F
T
V
L
--------------------------
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
N
I
Y
H
Q
S
F
K
N
G
--
G
S
P
S
S
G
L
V
K
K
G
K
--
T
--
K
---
K
--
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
K
A
-
S
-
T
S
-
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
S
GK
E
----
R
--------------
Q
E
H
Y
H
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
43.90
71%
-12
- C3 -
4URN
2
?
B:
[32-223]
--------------------------------
G
S
T
-
D
-
K
-
R
G
L
H
H
L
V
Y
E
I
V
D
N
S
V
D
E
V
L
N
G
Y
G
N
---
E
I
D
V
T
I
N
K
D
-
G
S
I
S
I
E
D
N
G
R
G
M
P
T
G
-
I
H
-
K
S
-
G
K
P
T
V
E
V
I
F
T
V
L
-------------------------
G
V
G
A
S
V
V
N
A
L
S
E
W
L
E
V
E
I
H
R
D
G
N
I
Y
H
Q
S
F
K
N
G
--
G
S
P
S
S
G
L
V
K
K
G
K
--
T
--
K
---
K
--
T
G
T
K
V
T
F
K
-------
P
D
D
T
I
F
K
A
-
S
-
T
S
-
F
N
F
D
V
L
S
E
R
L
Q
E
S
A
F
L
L
K
N
L
K
I
T
L
N
D
L
R
S
GK
E
----
R
--------------
Q
E
H
Y
H
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
43.42
54%
-1
- C3 -
4DUH
1
GYRB_ECOLI
A:
[15-217]
-------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
E
-
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
---------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
---
G
V
P
Q
A
P
L
A
V
T
G
E
--
T
--
E
---
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
-
N
-
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
--
G
----
K
--------------
E
D
H
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
43.24
55%
-2
- C3 -
4DUH
1
GYRB_ECOLI
A:
[15-217]
-------------------
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
-
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
N
S
---------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
---
G
V
P
Q
A
P
L
A
V
T
G
E
--
T
--
E
---
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
-
N
V
T
E
-
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
--
G
----
K
--------------
E
D
H
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
HHSearch
41.41
51%
-26
- C3 -
5CPH
2
?
A:
[17-208]
----------
A
G
Q
I
-
Q
V
L
E
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
Q
-
E
K
--------
M
G
R
P
A
-
V
E
V
I
L
---------------------
T
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
---
G
V
P
Q
F
D
L
K
E
V
G
T
--
T
--
D
---
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
-
T
-
E
T
T
V
-
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
--
E
E
N
V
-
R
--------------
E
D
S
Y
H
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
41.01
54%
-11
- C3 -
4DUH
1
GYRB_ECOLI
B:
[12-217]
----------------
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
H
C
K
---
E
I
I
V
T
I
H
A
D
-
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
E
-
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
-------------------
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
G
K
I
H
R
Q
I
Y
E
H
---
G
V
P
Q
A
P
L
A
V
T
G
E
--
T
--
E
---
K
--
T
G
T
M
V
R
F
W
-------
P
S
L
E
T
F
-
T
-
N
-
V
T
E
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
N
S
G
V
S
I
R
L
R
D
K
R
D
--
G
----
K
--------------
E
D
H
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
39.46
58%
-18
* C3 *
4K4O
2
GYRB_ENTFA
A:
[1-196]
-------------------
G
L
E
A
V
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
G
-
E
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
F
A
K
---
S
I
Q
V
I
I
E
P
D
-
D
S
I
T
V
I
D
D
G
R
G
I
P
V
G
-
I
Q
-
A
K
T
G
R
P
A
V
E
T
V
F
T
V
L
---------------------------
G
S
S
V
V
N
A
L
S
T
S
L
D
V
R
V
Y
K
D
G
K
V
Y
Y
Q
E
Y
R
R
---
G
A
V
V
D
D
L
K
V
I
E
E
--
T
--
D
---
R
--
H
G
T
T
V
H
F
I
-------
P
D
P
E
I
F
-
T
-
E
T
T
V
-
Y
D
F
D
K
L
A
T
R
V
R
E
L
A
F
L
N
R
G
L
H
I
S
I
E
D
R
R
E
--
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
HHSearch
39.41
48%
12
- C3 -
3FV5
1
PARE_ECOLI
A:
[1-201]
-------------------
G
L
E
P
V
R
R
R
P
G
M
Y
T
D
T
------
T
R
P
N
H
L
G
Q
E
V
I
D
N
S
V
D
E
A
L
A
G
H
A
K
---
R
V
D
V
I
L
H
A
D
-
Q
S
L
E
V
I
D
D
G
R
G
M
P
V
D
-
I
H
-
P
E
E
G
V
P
A
V
E
L
I
L
C
R
L
----------------------------
I
S
V
V
N
A
L
S
K
R
V
E
V
N
V
R
R
D
G
Q
V
Y
N
I
A
F
E
N
---
G
E
K
V
Q
D
L
Q
V
V
G
T
C
G
K
--
R
---
N
--
T
G
T
S
V
H
F
W
-------
P
D
E
T
F
F
-
D
-
S
-
P
R
-
F
S
V
S
R
L
T
H
V
L
K
A
K
A
V
L
C
P
G
V
E
I
T
F
K
D
E
I
N
--
N
----
T
--------------
E
Q
R
W
C
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
35.37
58%
8
- C3 -
4URO
1
GYRB_STAAU
A:
[26-231]
---------------------
E
A
A
R
K
R
P
G
M
Y
I
G
S
T
-
S
-
E
-
R
G
L
H
H
L
V
W
E
I
V
D
N
S
I
D
E
A
L
A
G
Y
A
N
---
Q
I
E
V
V
I
E
K
D
-
N
W
I
K
V
T
D
N
G
R
G
I
P
V
D
-
I
Q
-
E
K
M
G
R
P
A
V
E
V
I
L
T
V
--------------------------
G
V
G
S
S
V
V
N
A
L
S
Q
D
L
E
V
Y
V
H
R
N
E
T
I
Y
H
Q
A
Y
K
K
---
G
V
P
Q
F
D
L
K
E
V
G
T
--
T
--
D
---
K
--
T
G
T
V
I
R
F
K
-------
A
D
G
E
I
F
-
T
-
E
T
T
V
-
Y
N
Y
E
T
L
Q
Q
R
I
R
E
L
A
F
L
N
K
G
I
Q
I
T
L
R
D
E
R
D
--
E
E
N
V
-
R
--------------
E
D
S
Y
H
Y
E
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Fugue
34.43
52%
37
- C3 -
1EI1
6
GYRB_ECOLI
A:
[1-219]
-----
S
N
S
S
D
S
S
S
I
K
-
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
T
-
D
D
G
-
T
G
L
H
H
M
V
F
E
V
V
D
N
A
I
D
E
A
L
A
G
---HCK
E
I
I
V
T
I
H
A
-D
N
S
V
S
V
Q
D
D
G
R
G
I
P
T
G
-
I
H
P
E
E
-
G
V
S
A
A
E
V
I
M
T
V
L
H
A
G
G
K
F
D
D
-------NSYKVSG
G
L
H
G
V
G
V
S
V
V
N
A
L
S
Q
K
L
E
L
V
I
Q
R
E
--
G
K
I
H
R
Q
I
Y
E
----
H
G
V
P
Q
A
P
L
A
V
--
T
--
G
ETE
K
--
T
G
T
M
V
R
F
W
P
SLETFT-------
N
-
V
-
T
E
-
F
E
Y
E
I
L
A
K
R
L
R
E
L
S
F
L
D
S
G
V
S
I
R
L
R
D
-
K
R
--
D
----
G
--------------
K
E
D
H
F
H
Y
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------