@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18100: (2016-06-28 )
MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPAMFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVAIHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVIATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIEELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVHQLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHYKAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAGVKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELKKNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTAVWRLHTEQ
Atome Classification :
(59 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.----...----...210.......220.......230.......240.......-250.......260.......270.......280.......290.-..-.-...300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410-----------------------------........420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQ
P
E
L
FHDL
P
L
E
E
V
I
G
D
RFG
R
Y
S
K
Y
I
I
QDRALPD
A
R
D
G
L
K
P
V
Q
R
R
I
L
Y
A
MHTDGN
T
F
D
K
N
F
R
K
A
A
K
T
V
G
N
V
IGNYHPHG
D
S
S
V
Y
E
A
M
V
RMSQDW
K
V
R
N
V
L
I
E
M
HGNNGSIDGDPP
A
A
M
R
Y
T
E
A
R
L
S
P
I
A
S
E
L
L
R
DIDKN
T
V
E
FVPNFDDTSKE
P
V
V
L
PAMF
P
N
L
L
VNGSTGISAGYATDI
P
P
H
H
L
G
E
V
I
D
A
V
I
K
RIQMPSC
S
----
V
D
E
----
L
M
E
V
IKGPDFPTG
G
I
I
Q
G
V
D
G
I
R
K
A
Y
ETGK
G
K
I
I
I
RGK
A
E
I
E
T
-IRGGR
E
Q
I
V
I
T
EIPFEV
N
K
A
N
L
V
K
K
M
D
E
F
R
I
D
K
K
V
E
G
I
S
E
V
RDE-TD-R-T
G
L
R
V
V
I
E
LKKEA
D
A
K
G
I
L
N
F
L
YKNT
D
L
Q
I
T
Y
N
F
N
M
V
A
IHNRR
P
M
L
M
S
L
P
S
I
L
D
A
Y
IG
H
Q
K
E
VVTNR
S
V
Y
E
L
Q
K
AK
D
R
H
H
I
V
E
G
L
M
K
A
L
S
I
L
D
E
V
I
A
T
I
RSSSDKRDAKNN
L
I
A
K
------------------------------
Y
EFTEP
Q
A
E
A
I
V
S
L
Q
L
Y
R
LTNT
D
I
T
A
L
K
E
E
A
E
E
L
G
K
K
I
E
E
L
E
S
I
L
SN
D
K
K
L
L
K
V
I
T
N
S
L
K
A
L
K
K
K
Y
A
D
T
R
R
S
V
I
E
E
K
I
E
E
I
K
I
N
L
E
V
M
V
ASE
D
V
Y
V
T
VTKDG
Y
L
KRTSQRSFAASNGQDFGM
K
D
T
D
R
M
L
H
Q
FEMNT
T
D
V
L
L
L
F
TNKG
S
Y
I
Y
CPVHQLPD
I
R
W
K
D
M
G
Q
H
F
S
N
L
I
T
IDRDE
T
I
V
K
AIPIKEFDP
S
A
Y
L
L
F
F
TKNG
M
V
KK
T
E
L
T
H
Y
K
A
Q
R
YS
K
A
L
V
A
L
NLKGED
E
L
I
D
V
H
VTNGE
S
Q
I
F
M
A
T
HLG
Y
G
L
W
FGEDE
V
N
V
V
GARAAGVKGINLKED
D
F
V
VS
G
E
I
LQQSD
S
I
V
L
F
TQRGAVKRM
S
L
S
E
F
E
K
T
S
R
AKR
G
V
V
M
L
R
E
L
KKNP
H
R
V
V
A
L
F
A
CG
L
E
Q
R
L
M
A
ETEKG
D
R
K
E
L
Q
T
K
ELRTNDRYSNG
S
F
F
F
DEEESG
K
V
T
A
V
W
R
LHTEQ
11
PsiBlast_PDB
95.97
64%
0
- C- -
4KPF
-
PARC_STRPN
A:
[4--61]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
95.97
64%
0
- C- -
4KPE
-
PARC_STRPN
A:
[4--61]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
95.97
64%
0
- C- -
4KOE
-
PARC_STRPN
A:
[4--61]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
95.97
64%
0
- C- -
3RAE
-
PARC_STRPN
A:
[4--61]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.38
64%
-67
- C5 -
3RAD
5
PARC_STRPN
A:
[4-484]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.22
64%
-67
- C5 -
3RAF
5
PARC_STRPN
A:
[4-484]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
84.95
64%
-69
- C5 -
3RAD
6
PARC_STRPN
B:
[4-484]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.91
64%
-65
- C5 -
4KPE
6
PARC_STRPN
B:
[4-484]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
84.71
64%
-71
- C5 -
4KPF
5
PARC_STRPN
B:
[4-484]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
84.62
64%
-69
- C5 -
3K9F
4
PARC_STRPN
B:
[4-483]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.61
64%
-69
- C5 -
3K9F
4
PARC_STRPN
A:
[4-483]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.54
64%
-76
- C5 -
3KSA
2
PARC_STRPN
A:
[4-483]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.44
64%
-69
- C5 -
3RAF
5
PARC_STRPN
B:
[4-484]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
84.36
64%
-77
- C5 -
3KSA
2
PARC_STRPN
B:
[4-483]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.08
64%
-80
- C5 -
3KSB
2
PARC_STRPN
A:
[4-483]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
---
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.01
64%
-67
- C5 -
4KOE
5
PARC_STRPN
B:
[4-484]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.95
64%
-68
- C5 -
3RAE
4
PARC_STRPN
B:
[4-484]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
83.93
64%
-80
- C5 -
3KSB
2
PARC_STRPN
B:
[4-483]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
---
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.66
64%
-71
- C5 -
3LTN
4
PARC_STRPN
B:
[4-483]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.52
64%
-71
- C5 -
3LTN
4
PARC_STRPN
A:
[4-483]
------
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
----
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
T
E
I
E
K
-
L
K
G
G
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
V
S
------------------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
78.99
51%
-24
- C5 -
5CDN
7
GYRA_STAAN (first)
C:
[13-480]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.12
51%
-20
- C5 -
5CDP
4
GYRA_STAAN
C:
[14-481]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
77.91
51%
-21
- C5 -
5CDR
4
GYRA_STAAN
C:
[14-481]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
77.88
51%
-22
- C5 -
5CDN
5
GYRA_STAAN (first)
A:
[13-480]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
77.71
51%
-22
- C5 -
5BS3
4
GYRA_STAAU (first)
D:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
77.71
51%
-19
- C5 -
2XCS
3
GYRA_STAAN (first)
D:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.70
51%
-24
- C5 -
5BS3
4
GYRA_STAAU (first)
B:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.70
51%
-22
- C5 -
4BUL
4
GYRA_STAAN
A:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
77.68
51%
-21
- C5 -
4PLB
6
GYRA_STAAU (first)
D:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.67
51%
-20
- C5 -
4PLB
5
GYRA_STAAU (first)
B:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
77.39
51%
-24
- C5 -
5CDQ
7
GYRA_STAAN
A:
[13-480]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.13
51%
-19
- C5 -
5CDP
6
GYRA_STAAN
A:
[14-481]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.07
51%
-20
- C5 -
5CDR
8
GYRA_STAAN
A:
[14-481]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.02
51%
-19
- C5 -
2XCS
4
GYRA_STAAN (first)
B:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
77.01
51%
-22
- C5 -
5CDQ
7
GYRA_STAAN
C:
[13-480]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
76.74
51%
-23
- C5 -
4BUL
3
GYRA_STAAN
C:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
76.16
51%
-22
- C5 -
2XCR
3
GYRA_STAAN (first)
D:
[257-724]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
75.81
51%
-20
- C5 -
2XCT
4
GYRA_STAAN
S:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
75.72
51%
-25
- C5 -
2XCR
3
GYRA_STAAN (first)
U:
[257-724]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
75.57
51%
-21
- C5 -
2XCT
3
GYRA_STAAN
D:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
75.32
51%
-22
- C5 -
2XCR
3
GYRA_STAAN (first)
B:
[257-724]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
75.08
45%
-33
- C5 -
2Y3P
1
GYRA_ECOLI (first)
B:
[12-520]
-----------
I
E
E
E
L
K
S
S
Y
L
D
Y
A
M
S
V
I
V
G
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
N
V
L
G
N
D
W
N
K
A
Y
K
K
S
A
R
V
V
G
D
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
D
T
I
V
R
M
A
Q
P
F
S
L
R
Y
M
L
V
D
G
Q
G
N
F
G
S
I
D
G
D
S
A
A
A
M
R
Y
T
E
I
R
L
A
K
I
A
H
E
L
M
A
D
L
E
K
E
T
V
D
F
V
D
N
Y
D
G
T
E
K
I
P
D
V
M
P
T
K
I
P
N
L
L
V
N
G
S
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
V
I
N
G
C
L
A
Y
I
D
D
E
D
I
S
----
I
E
G
----
L
M
E
H
I
P
G
P
D
F
P
T
A
A
I
I
N
G
R
R
G
I
E
E
A
Y
R
T
G
R
G
K
V
Y
I
R
A
R
A
E
V
E
V
D
A
K
T
G
R
E
T
I
I
V
H
E
I
P
Y
Q
V
N
K
A
R
L
I
E
K
I
A
E
L
V
K
E
K
R
V
E
G
I
S
A
L
R
D
E
-
S
D
-
K
-
D
G
M
R
I
V
I
E
V
K
R
D
A
V
G
E
V
V
L
N
N
L
Y
S
Q
T
Q
L
Q
V
S
F
G
I
N
M
V
A
L
H
H
G
Q
P
K
I
M
N
L
K
D
I
I
A
A
F
V
R
H
R
R
E
V
V
T
R
R
T
I
F
E
L
R
K
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
L
I
R
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
PWQLGNVAAMLEDAARPEWLEPEFGVRDG
L
Y
Y
L
T
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
L
R
I
L
G
S
A
D
R
L
M
E
V
I
R
E
E
L
E
L
V
R
E
Q
F
G
D
K
R
R
T
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.02
51%
-20
- C5 -
2XCT
3
GYRA_STAAN
B:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
75.01
51%
-21
- C5 -
2XCR
3
GYRA_STAAN (first)
S:
[257-724]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
74.86
51%
-27
- C5 -
2XCT
5
GYRA_STAAN
U:
[223-690]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
73.92
45%
-34
- C5 -
2Y3P
1
GYRA_ECOLI (first)
A:
[22-520]
---------------------
D
Y
A
M
S
V
I
V
G
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
N
V
L
G
N
D
W
N
K
A
Y
K
K
S
A
R
V
V
G
D
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
D
T
I
V
R
M
A
Q
P
F
S
L
R
Y
M
L
V
D
G
Q
G
N
F
G
S
I
D
G
D
S
A
A
A
M
R
Y
T
E
I
R
L
A
K
I
A
H
E
L
M
A
D
L
E
K
E
T
V
D
F
V
D
N
Y
D
G
T
E
K
I
P
D
V
M
P
T
K
I
P
N
L
L
V
N
G
S
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
V
I
N
G
C
L
A
Y
I
D
D
E
D
I
S
----
I
E
G
----
L
M
E
H
I
P
G
P
D
F
P
T
A
A
I
I
N
G
R
R
G
I
E
E
A
Y
R
T
G
R
G
K
V
Y
I
R
A
R
A
E
V
E
V
D
A
K
T
G
R
E
T
I
I
V
H
E
I
P
Y
Q
V
N
K
A
R
L
I
E
K
I
A
E
L
V
K
E
K
R
V
E
G
I
S
A
L
R
D
E
-
S
D
-
K
-
D
G
M
R
I
V
I
E
V
K
R
D
A
V
G
E
V
V
L
N
N
L
Y
S
Q
T
Q
L
Q
V
S
F
G
I
N
M
V
A
L
H
H
G
Q
P
K
I
M
N
L
K
D
I
I
A
A
F
V
R
H
R
R
E
V
V
T
R
R
T
I
F
E
L
R
K
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
L
I
R
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
P
W
Q
LGNVAAMLEDAARPEWLEPEFGVRDG
L
Y
Y
L
T
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
L
R
I
L
G
S
A
D
R
L
M
E
V
I
R
E
E
L
E
L
V
R
E
Q
F
G
D
K
R
R
T
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
71.26
45%
15
- C5 -
3ILW
4
GYRA_MYCTU
B:
[8-468]
-----------------------------
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
----
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
E
E
-
D
S
R
G
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
S
D
-
R
-
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
E
L
------------------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
71.22
45%
14
- C5 -
3IFZ
2
GYRA_MYCTU
A:
[31-498]
----------------------
Y
A
M
S
V
I
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
----
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
E
E
-
D
S
R
----
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
S
D
-
R
-
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
E
L
------------------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
71.11
45%
17
- C5 -
3ILW
4
GYRA_MYCTU
A:
[7-468]
----------------------------
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
----
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
E
E
-
D
S
R
G
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
S
D
-
R
-
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
E
L
------------------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
71.09
45%
16
* C5 *
3ILW
4
GYRA_MYCTU
A:
[7-469]
----------------------------
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
E
E
E
T
L
A
A
----
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
E
E
-
D
S
R
G
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
-
S
S
-
D
R
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
E
L
------------------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
70.65
45%
18
- C5 -
3IFZ
2
GYRA_MYCTU
B:
[31-498]
----------------------
Y
A
M
S
V
I
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
----
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
V
E
V
E
E
-
D
S
R
G
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
S
D
-
R
-
V
G
L
R
I
V
I
E
I
K
R
D
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
E
L
------------------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
60.93
51%
21
- C5 -
5CDN
2
GYRA_STAAN
T:
[13-480]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
60.89
51%
20
- C5 -
5CDQ
2
GYRA_STAAN
T:
[13-480]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
60.87
51%
17
- C5 -
5CDQ
2
GYRA_STAAN
R:
[13-480]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
60.87
51%
17
- C5 -
5CDO
8
GYRA_STAAN
T:
[14-481]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
60.14
51%
23
- C5 -
5CDM
4
GYRA_STAAN
C:
[14-481]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
59.89
51%
24
- C5 -
5CDO
7
GYRA_STAAN
C:
[14-481]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-
R
G
G
G
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
59.61
51%
19
- C5 -
5CDN
2
GYRA_STAAN
R:
[13-480]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
G
D
G
A
A
A
M
R
-
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
-----
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
A
--
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
Q
R
------------------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
59.21
51%
24
- C5 -
5CDO
9
GYRA_STAAN
R:
[14-481]
-------------------
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
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