@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18210: (2016-06-29 )
MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLFDDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKIIRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLLFGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSISGCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAPFDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSADKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSVIVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAAFISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPVYPV
Atome Classification :
(22 SA)
.........10.......-----.20........30........40.....-.---.-.50......-.----.60-----.-------...-------.-----....70........80........90........100.......110.......120.......130.......140........150..-......160.......170.......180.-...-...190.......200.......210.......220.......230.......240...-------....250.....--.----..260...--...-------..270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......--430.......440..-----...--.------.-..450.......460-.-..-....470-.......480.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLMD
Y
E
K
E
R
T
E
R
A
E
R
I
R
K-----G
G
A
E
K
Y
H
Q
SNRE
K
G
K
L
F
V
R
E
R
L
S
L
LFDD-D---I-E
L
E
D
A
F
F
A
E
-
C
----
M
S------D-------GLP-------A-----
D
G
V
V
T
A
I
G
KIGG
Q
T
V
C
V
MAND
S
T
VKAGSW
G
A
K
T
V
E
K
I
I
R
I
Q
E
I
A
E
KLNC
P
L
I
Y
L
VDSAG
A
R
I
T
D
Q
I
NVFPGRRGA-G
R
I
F
Y
N
Q
V
K
LS-GR-I
P
Q
I
C
L
L
FGPSAAGGAYI
P
A
F
C
D
I
V
V
M
VDG-NA
S
-
M
Y
LGS
P
R
M
A
E
M
V
IGEKV
S
L
E
EMGG
A
R
M
H
C
S
ISG
C
G
D
I
L
AE
T
E
E
E
A
I
Q
L
V
R
A
Y
L
S
YFPAN-------FQEKAP-IHEKR--P----PKH-FET
P
--
L
A
D
-------VIPQNQNAPF
D
M
H
E
L
I
E
R
VIDEDS
F
F
E
I
K
A
L
F
A
P
E
L
L
T
G
L
A
R
IHGQP
V
G
I
VANQPKVKG
G
V
L
F
HDSA
D
K
A
A
K
F
I
T
L
C
D
A
F
H
I
P
L
L
F
LADIPGFMIGTK
V
E
Q
A
G
I
I
R
H
G
A
K
M
I
S
A
M
S
EAT
V
P
K
L
S
V
I
V
R
K
AYGAGLYAMAGPAFEPD
C
C
L
ALPT
A
Q
I
A
V
MG
P
E
--
A
A
V
N
A
V
Y
A
K
K
I
--
A
E-----L
P
E
--
E
------
E
-
R
A
A
F
I
S
S
K
R
E
E
Y
K
E
D
-
I
-
N
I
-
Y
R
L
A
S
E
M
-
I
I
D
AVI
P
A
N
S
L
R
D
E
L
A
K
R
L
K
A
Y
M
T
K
EMTFTNRKHPVYPV
46
HHSearch
82.70
41%
-8
- C4 -
1VRG
2
?
A:
[15-527]
-
L
R
D
K
I
E
E
L
K
K
I
E
K
E
I
E
Q
-----
G
G
G
P
E
K
V
E
K
Q
H
R
A
G
K
L
T
A
W
E
R
L
E
L
L
L
D
P
-
G
---
T
-
F
V
E
I
D
K
F
V
E
-
H
----
R
N
TYFGLD
K
V
------
K
L
P
-------
R
-----
D
G
V
I
T
G
V
G
E
I
N
G
R
K
V
A
V
F
S
Q
D
F
T
V
M
G
G
S
L
G
E
M
H
A
K
K
I
V
K
L
L
D
L
A
L
K
M
G
I
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
A
---
L
A
G
Y
-
G
E
I
F
L
R
N
T
L
A
S
-
G
V
-
V
P
Q
I
T
V
I
A
G
P
C
A
G
G
A
V
Y
S
P
A
L
T
D
F
I
V
M
V
D
Q
-
T
A
R
-
M
F
I
T
G
P
N
V
I
K
A
V
T
G
E
E
I
S
Q
E
D
L
G
G
A
M
V
H
N
Q
K
S
G
N
A
H
F
L
A
D
N
D
E
K
A
M
S
L
V
R
T
L
L
S
Y
L
P
S
N
-------
N
A
E
E
P
P
-
V
-
E
D
P
D-
T
----
S
L
E
-
T
P
E
D
--
I
L
D
-------
I
L
P
D
N
P
N
K
G
Y
D
V
R
D
V
I
K
R
V
V
D
H
G
E
F
F
E
V
Q
P
Y
F
A
K
N
I
V
I
G
F
A
R
I
Q
G
K
T
V
G
I
V
A
N
Q
P
S
V
L
A
G
V
L
D
I
D
S
S
D
K
A
A
R
F
I
R
F
L
D
A
F
N
I
P
I
L
T
F
V
D
T
P
G
Y
L
P
G
V
A
Q
E
H
G
G
I
I
R
H
G
A
K
L
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
I
L
R
K
A
Y
G
G
A
Y
I
A
M
G
S
K
H
L
G
A
D
M
V
L
A
W
P
S
A
E
I
A
V
M
G
P
E
--
G
A
A
N
I
I
F
K
R
E
I
--
E
A
-----
S
S
N
--
P
------
E
---
E
T
R
R
K
L
I
E
E
Y
K
Q
Q
-
F
A
N
P
-
Y
I
A
A
S
R
G
-
Y
V
D
M
V
I
D
P
R
E
T
R
K
Y
I
M
R
A
L
E
V
C
E
T
K
V
E
Y
R
P
K
K
K
H
G
N
I
P
L
52
HHSearch
82.13
40%
-11
- C4 -
1X0U
-
?
A:
[12-523]
----
L
I
E
E
L
R
Q
L
K
E
K
A
Y
K
-----
G
G
G
D
E
R
I
Q
F
Q
H
S
K
G
K
L
T
A
R
E
R
L
A
L
L
F
D
D
-
G
---
K
-
F
N
E
I
M
T
F
A
T
-
T
----
R
A
TEFGLD
K
Q------
R
F
Y
-------
G
-----
D
G
V
V
T
G
W
G
K
V
D
G
R
T
V
F
A
Y
A
Q
D
F
T
V
L
G
G
S
L
G
E
T
H
A
N
K
I
V
R
A
Y
E
L
A
L
K
V
G
A
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
A
L
S
---
L
E
G
Y
-
G
A
V
F
K
M
N
V
M
A
S
-
G
V
-
I
P
Q
I
T
I
M
A
G
P
A
A
G
G
A
V
Y
S
P
A
L
T
D
F
I
I
M
I
K
G
D
A
Y
Y
-
M
F
V
T
G
P
E
I
T
K
V
V
L
G
E
E
V
S
F
Q
D
L
G
G
A
V
V
H
A
T
K
S
G
V
V
H
F
M
V
D
S
E
Q
E
A
I
N
L
T
K
R
L
L
S
Y
L
P
S
N
-------
N
M
E
E
P
P
-
Y
-
I
D
T
G-
D
P---
A
D
R
-
D
A
T
G
--
V
E
Q
-------
I
V
P
N
D
A
A
K
P
Y
N
M
R
E
I
I
Y
K
I
V
D
N
G
E
F
L
E
V
H
K
H
W
A
Q
N
I
I
V
G
F
A
R
I
A
G
N
V
V
G
I
V
A
N
N
P
E
E
F
G
G
S
I
D
I
D
A
A
D
K
A
A
R
F
I
R
F
C
D
A
F
N
I
P
L
I
S
L
V
D
T
P
G
Y
V
P
G
T
D
Q
E
Y
K
G
I
I
R
H
G
A
K
M
L
Y
A
F
A
E
A
T
V
P
K
I
T
V
I
V
R
K
S
Y
G
G
A
H
I
A
M
S
I
K
S
L
G
A
D
L
V
Y
A
W
P
T
A
E
I
A
V
T
G
P
E
--
G
A
V
R
I
L
Y
R
K
E
I
--
Q
Q
-----
A
S
N
--
P
---------
D
D
V
L
K
Q
R
I
A
E
Y
R
K
L
-
F
A
N
P
-
Y
W
A
A
E
K
G
-
L
V
D
D
V
I
E
P
K
D
T
R
R
V
I
V
A
G
L
E
M
L
K
T
K
R
E
Y
R
Y
P
K
K
H
G
N
I
P
L
53
HHSearch
81.31
39%
-18
- C4 -
3IAV
6
?
A:
[16-530]
---
G
K
L
A
D
L
R
R
R
I
E
E
A
T
H
-----
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
-
G
---
S
-
F
V
E
L
D
E
F
A
R
-
H
----
R
S
TNFGLD
A
N------
R
P
Y
-------
G
-----
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
---
L
G
A
Y
-
G
E
I
F
R
R
N
T
H
A
S
-
G
V
-
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
-
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
-------
N
L
S
E
P
P
-
A
-
F
P
E
E
A
D
LA--
V
T
D
-
E
D
A
E
--
L
D
T
-------
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
D
A
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F
F
E
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Q
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L
F
A
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I
L
T
G
F
G
R
V
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G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
V
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
--
G
A
V
N
I
L
H
R
R
T
I
--
A
D
-----
A
G
D
--
D
--------
A
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
-
L
L
N
P
-
Y
T
A
A
E
R
G
-
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
47
HHSearch
80.57
37%
-27
- C5 -
3U9R
3
?
B:
[46-555]
-----
V
N
A
L
R
T
L
L
G
R
I
H
E
-----
G
G
G
S
A
A
Q
A
R
H
S
A
R
G
K
L
L
V
R
E
R
I
N
R
L
L
D
P
-
G
---
S
P
F
L
E
L
S
A
L
A
A
-
H
----
E
V
Y-----
G
E------
E
V
A
-------
A
-----
A
G
I
V
A
G
I
G
R
V
E
G
V
E
C
M
I
V
G
N
D
A
T
V
K
G
G
T
Y
Y
P
L
T
V
K
K
H
L
R
A
Q
A
I
A
L
E
N
R
L
P
C
I
Y
L
V
D
S
G
G
A
N
L
P
R
Q
D
E
V
F
P
D
R
E
H
F
-
G
R
I
F
F
N
Q
A
N
M
S
A
R
G
-
I
P
Q
I
A
V
V
M
G
S
C
T
A
G
G
A
Y
V
P
A
M
S
D
E
T
V
M
V
R
E
-
Q
A
T
-
I
F
L
A
G
P
P
L
V
K
A
A
T
G
E
V
V
S
A
E
E
L
G
G
A
D
V
H
C
K
V
S
G
V
A
D
H
Y
A
E
D
D
D
H
A
L
A
I
A
R
R
C
V
A
N
L
N
W
R
-------
K
Q
G
Q
L
Q
-
C
-
R
A
P
R-
A
----
P
L
Y
-
P
A
E
E
--
L
Y
G
-------
V
I
P
A
D
S
K
Q
P
Y
D
V
R
E
V
I
A
R
L
V
D
G
S
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F
D
E
F
K
A
L
F
G
T
T
L
V
C
G
F
A
H
L
H
G
Y
P
I
A
I
L
A
N
N
-----
G
I
L
F
A
E
A
A
Q
K
G
A
H
F
I
E
L
A
C
Q
R
G
I
P
L
L
F
L
Q
N
I
T
G
F
M
V
G
Q
K
Y
E
A
G
G
I
A
K
H
G
A
K
L
V
T
A
V
A
C
A
R
V
P
K
F
T
V
L
I
G
G
S
F
G
A
G
N
Y
G
M
C
G
R
A
Y
D
P
R
F
L
W
M
W
P
N
A
R
I
G
V
M
G
G
E
--
Q
A
A
G
V
L
A
Q
V
K
R
--
E
Q
-----
A
E
R
--
A
GQQLGV
E
E
E
A
K
I
K
A
P
I
L
E
Q
Y
E
H
Q
-
G
-
H
P
-
Y
Y
S
S
A
R
L
-
W
D
D
G
V
I
D
P
A
Q
T
R
E
V
L
A
L
A
L
S
A
A
L
N
A
P
I
--
E
P
T
A
F
G
V
F
R
M
2
PsiBlast_PDB
80.44
39%
-8
- C4 -
1X0U
-
?
A:
[14-523]
------
E
E
L
R
Q
L
K
E
K
A
Y
K
-----
G
G
G
D
E
R
I
Q
F
Q
H
S
K
G
K
L
T
A
R
E
R
L
A
L
L
F
D
D
-
G
---
K
-
F
N
E
I
M
T
F
A
T
-
T
----
R
A
------
T
EF-----
G
L
D
KQRFY--
G
-----
D
G
V
V
T
G
W
G
K
V
D
G
R
T
V
F
A
Y
A
Q
D
F
T
V
L
G
G
S
L
G
E
T
H
A
N
K
I
V
R
A
Y
E
L
A
L
K
V
G
A
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
A
L
S
L
---
E
G
Y
-
G
A
V
F
K
M
N
V
M
A
S
-
G
V
-
I
P
Q
I
T
I
M
A
G
P
A
A
G
G
A
V
Y
S
P
A
L
T
D
F
I
I
M
I
K
G
-
D
A
Y
Y
M
F
V
T
G
P
E
I
T
K
V
V
L
G
E
E
V
S
F
Q
D
L
G
G
A
V
V
H
A
T
K
S
G
V
V
H
F
M
V
D
S
E
Q
E
A
I
N
L
T
K
R
L
L
S
Y
L
P
S
N
-------
N
M
E
E
P
P
Y
I
D
T
G
D
--
P
----
A
D
R
-
D
A
T
G
--
V
E
Q
-------
I
V
P
N
D
A
A
K
P
Y
N
M
R
E
I
I
Y
K
I
V
D
N
G
E
F
L
E
V
H
K
H
W
A
Q
N
I
I
V
G
F
A
R
I
A
G
N
V
V
G
I
V
A
N
N
P
E
E
F
G
G
S
I
D
I
D
A
A
D
K
A
A
R
F
I
R
F
C
D
A
F
N
I
P
L
I
S
L
V
D
T
P
G
Y
V
P
G
T
D
Q
E
Y
K
G
I
I
R
H
G
A
K
M
L
Y
A
F
A
E
A
T
V
P
K
I
T
V
I
V
R
K
S
Y
G
G
A
H
I
A
M
S
I
K
S
L
G
A
D
L
V
Y
A
W
P
T
A
E
I
A
V
T
G
P
E
--
G
A
V
R
I
L
Y
R
K
E
I
QQ
A
S
-----
N
P
D
--
D
------
V
-
L
K
Q
R
I
A
E
Y
R
K
L
F
A
-----
N
P
-
Y
W
A
A
E
K
G
-
L
V
D
D
V
I
E
P
K
D
T
R
R
V
I
V
A
G
L
E
M
L
K
T
K
R
E
Y
R
Y
P
K
K
H
G
N
I
P
L
1
PsiBlast_PDB
80.40
40%
7
- C4 -
1VRG
2
?
A:
[16-527]
------
R
D
K
I
E
E
L
K
K
I
E
K
E
I
E
QG
G
G
P
E
K
V
E
K
Q
H
R
-
A
G
K
L
T
A
W
E
R
L
E
L
L
L
D
P
-
G
---
T
-
F
V
E
I
D
K
F
V
E
-
H
----
R
N
------
T
YFGLDK
V
K
L
P
-------
R
-----
D
G
V
I
T
G
V
G
E
I
N
G
R
K
V
A
V
F
S
Q
D
F
T
V
M
G
G
S
L
G
E
M
H
A
K
K
I
V
K
L
L
D
L
A
L
K
M
G
I
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
A
L
A
G
Y
----
G
E
I
F
L
R
N
T
L
A
S
-
G
V
-
V
P
Q
I
T
V
I
A
G
P
C
A
G
G
A
V
Y
S
P
A
L
T
D
F
I
V
M
V
D
Q
-
T
A
R
-
M
F
I
T
G
P
N
V
I
K
A
V
T
G
E
E
I
S
Q
E
D
L
G
G
A
M
V
H
N
Q
K
S
G
N
A
H
F
L
A
D
N
D
E
K
A
M
S
L
V
R
T
L
L
S
Y
L
P
S
N
-------
N
A
E
E
P
P
-
V
E
D
----
P
----
D
T
S
-
L
E
T
P
ED
I
L
D
-------
I
L
P
D
N
P
N
K
G
Y
D
V
R
D
V
I
K
R
V
V
D
H
G
E
F
F
E
V
Q
P
Y
F
A
K
N
I
V
I
G
F
A
R
I
Q
G
K
T
V
G
I
V
A
N
Q
P
S
V
L
A
G
V
L
D
I
D
S
S
D
K
A
A
R
F
I
R
F
L
D
A
F
N
I
P
I
L
T
F
V
D
T
P
G
Y
L
P
G
V
A
Q
E
H
G
G
I
I
R
H
G
A
K
L
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
I
L
R
K
A
Y
G
G
A
Y
I
A
M
G
S
K
H
L
G
A
D
M
V
L
A
W
P
S
A
E
I
A
V
M
G
P
E
--
G
A
A
N
I
I
F
K
R
E
I
E
A
S
S
-----
N
P
E
--
E
------
T
-
R
R
K
L
I
----
E
E
Y
K
Q
Q
-
F
A
N
P
-
Y
I
A
A
S
R
G
-
Y
V
D
M
V
I
D
P
R
E
T
R
K
Y
I
M
R
A
L
E
V
C
E
T
K
V
E
Y
R
P
K
K
K
H
G
N
I
P
L
35
PsiBlast_CBE
80.17
37%
-13
- C4 -
3N6R
2
?
H:
[26-531]
-----
L
E
Q
L
E
D
R
R
A
A
A
R
L
-----
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
---
F
-
E
E
F
D
M
F
V
T
H
R
C
TDFN
M
Q
------
D
-------
Q
K
P
-------
A
G----
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
----
G
E
V
F
Q
R
N
I
M
A
S
-
G
V
-
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
-
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
-------
N
R
E
K
P
P
-
V
---
R
--
P
FFDD
P
D
R
-
I
E
P
S
--
L
D
T
-------
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
--
G
A
T
E
I
I
H
R
G
D
L
--
G
D
------
P
E
--
K
------------
I
A
Q
H
T
A
D
Y
E
E
R
-
F
-
A
N
-
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
36
PsiBlast_CBE
79.86
37%
-12
- C4 -
3N6R
2
?
F:
[26-531]
-----
L
E
Q
L
E
D
R
R
A
A
A
R
L
-----
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
---
F
-
E
E
F
D
M
F
V
T
H
R
C
TDFN
M
Q
------
D
-------
Q
K
P
-------
A
G----
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
----
G
E
V
F
Q
R
N
I
M
A
S
-
G
V
-
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
-
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
-------
N
R
E
K
P
P
-
V
---
R
--
P
FFDD
P
D
R
-
I
E
P
S
--
L
D
T
-------
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
--
G
A
T
E
I
I
H
R
G
D
L
--
G
D
------
P
E
--
K
------------
I
A
Q
H
T
A
D
Y
E
E
R
-
F
-
A
N
-
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
34
PsiBlast_CBE
79.80
37%
-14
- C4 -
3N6R
2
?
J:
[26-531]
-----
L
E
Q
L
E
D
R
R
A
A
A
R
L
-----
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
---
F
-
E
E
F
D
M
F
V
T
H
R
C
TDFN
M
Q
------
D
-------
Q
K
P
-------
A
G----
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
----
G
E
V
F
Q
R
N
I
M
A
S
-
G
V
-
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
-
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
-------
N
R
E
K
P
P
-
V
---
R
--
P
FFDD
P
D
R
-
I
E
P
S
--
L
D
T
-------
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
--
G
A
T
E
I
I
H
R
G
D
L
--
G
D
------
P
E
--
K
------------
I
A
Q
H
T
A
D
Y
E
E
R
-
F
-
A
N
-
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
51
HHSearch
79.78
38%
-7
* C4 *
1ON3
5
12S_PROFR
A:
[12-523]
-
M
E
G
R
V
E
Q
L
A
E
Q
R
Q
V
I
E
A
-----
G
G
G
E
R
R
V
E
K
Q
H
S
Q
G
K
Q
T
A
R
E
R
L
N
N
L
L
D
P
-
H
---
S
-
F
D
E
V
G
A
F
R
K
-
H
----
R
T
TLFGMD
K
A
------
V
V
P
-------
A
-----
D
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
---
L
S
G
Y
-
G
K
M
F
F
A
N
V
K
L
S
-
G
V
-
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
K
--
A
H
-
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
-------
N
T
E
E
A
S
-
F
-
V
N
P
N-
N
----
D
V
S
-
P
N
T
E
--
L
R
D
-------
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
--
G
A
A
N
V
I
F
R
K
E
I
--
K
A
-----
A
D
D
--
P
---------
D
A
M
R
A
E
K
I
E
E
Y
Q
N
A
-
F
N
T
P
-
Y
V
A
A
A
R
G
-
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
P
A
K
K
H
G
N
F
P
C
33
PsiBlast_CBE
79.54
37%
-15
- C4 -
3N6R
2
?
L:
[26-531]
-----
L
E
Q
L
E
D
R
R
A
A
A
R
L
-----
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
---
F
-
E
E
F
D
M
F
V
T
H
R
C
TDFN
M
Q
------
D
-------
Q
K
P
-------
A
G----
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
----
G
E
V
F
Q
R
N
I
M
A
S
-
G
V
-
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
-
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
-------
N
R
E
K
P
P
-
V
---
R
--
P
FFDD
P
D
R
-
I
E
P
S
--
L
D
T
-------
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
--
G
A
T
E
I
I
H
R
G
D
L
--
G
D
------
P
E
--
K
------------
I
A
Q
H
T
A
D
Y
E
E
R
-
F
-
A
N
-
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
37
PsiBlast_CBE
79.26
37%
-11
- C4 -
3N6R
2
?
D:
[26-531]
-----
L
E
Q
L
E
D
R
R
A
A
A
R
L
-----
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
---
F
-
E
E
F
D
M
F
V
T
H
R
C
TDFN
M
Q
------
D
-------
Q
K
P
-------
A
G----
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
----
G
E
V
F
Q
R
N
I
M
A
S
-
G
V
-
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
-
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
-------
N
R
E
K
P
P
-
V
---
R
--
P
FFDD
P
D
R
-
I
E
P
S
--
L
D
T
-------
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
--
G
A
T
E
I
I
H
R
G
D
L
--
G
D
------
P
E
--
K
------------
I
A
Q
H
T
A
D
Y
E
E
R
-
F
-
A
N
-
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
15
PsiBlast_PDB
79.26
37%
-12
- C4 -
3N6R
2
?
B:
[26-531]
-----
L
E
Q
L
E
D
R
R
A
A
A
R
L
-----
G
G
G
Q
K
R
I
D
A
Q
H
G
R
G
K
L
T
A
R
E
R
V
D
L
L
L
D
E
G
S
---
F
-
E
E
F
D
M
F
V
T
H
R
C
TDFN
M
Q
------
D
-------
Q
K
P
-------
A
G----
D
G
V
V
T
G
W
G
T
I
N
G
R
V
V
Y
V
F
S
Q
D
F
T
V
L
G
G
S
V
S
E
T
H
S
K
K
I
C
K
I
M
D
M
A
M
Q
N
G
A
P
V
I
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
D
S
L
A
G
Y
----
G
E
V
F
Q
R
N
I
M
A
S
-
G
V
-
V
P
Q
I
S
M
I
M
G
P
C
A
G
G
A
V
Y
S
P
A
M
T
D
F
I
F
M
V
K
D
-
S
S
Y
-
M
F
V
T
G
P
D
V
V
K
T
V
T
N
E
Q
V
S
A
E
E
L
G
G
A
T
T
H
T
R
K
S
S
V
A
D
A
A
F
E
N
D
V
E
A
L
A
E
V
R
R
L
V
D
F
L
P
L
N
-------
N
R
E
K
P
P
-
V
---
R
--
P
F
FDD
P
D
R
-
I
E
P
S
--
L
D
T
-------
L
V
P
D
N
P
N
T
P
Y
D
M
K
E
L
I
H
K
L
A
D
E
G
D
F
Y
E
I
Q
E
E
F
A
K
N
I
I
T
G
F
I
R
L
E
G
R
T
V
G
V
V
A
N
Q
P
L
V
L
A
G
C
L
D
I
D
S
S
R
K
A
A
R
F
V
R
F
C
D
A
F
E
I
P
L
L
T
L
I
D
V
P
G
F
L
P
G
T
S
Q
E
Y
G
G
V
I
K
H
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
M
V
T
V
I
T
R
K
A
Y
G
G
A
Y
V
V
M
S
S
K
H
L
R
A
D
F
N
Y
A
W
P
T
A
E
V
A
V
M
G
A
K
--
G
A
T
E
I
I
H
R
G
D
L
--
G
D
------
P
E
--
K
------------
I
A
Q
H
T
A
D
Y
E
E
R
-
F
-
A
N
-
P
F
V
A
S
E
R
G
F
V
D
E
V
I
Q
P
R
S
T
R
K
R
V
A
R
A
F
A
S
L
R
N
K
S
V
Q
M
P
W
K
K
H
D
N
I
P
L
32
PsiBlast_CBE
78.93
38%
-6
- C4 -
1ON3
6
12S_PROFR
B:
[21-522]
----------
E
Q
R
Q
V
I
E
A
-----
G
G
G
E
R
R
V
E
K
Q
H
S
Q
G
K
Q
T
A
R
E
R
L
N
N
L
L
D
P
-
H
---
S
-
F
D
E
V
G
A
F
R
K
-
H
----
R
T
------
T
LFGMDK
A
V
V
P
-------
A
-----
D
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
----
G
K
M
F
F
A
N
V
K
L
S
-
G
V
-
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
--
K
A
H
-
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
-------
N
T
E
E
A
S
-
F
V
N
P
N
--
N
----
D
V
S
-
P
N
T
E
--
L
R
D
-------
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
--
G
A
A
N
V
I
F
R
K
E
I
K
A
A
D
-----
D
P
D
--
A
------
M
-
R
A
----
E
K
I
E
E
Y
Q
N
A
-
F
-
N
T
P
Y
V
A
A
A
R
G
-
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
P
A
K
K
H
G
N
F
P
-
11
PsiBlast_PDB
78.89
40%
-8
- C4 -
2A7S
-
PCC5_MYCTU
A:
[29-548]
-
L
A
E
L
H
K
R
R
E
E
S
L
H
P
V
G
E
-----
D
A
V
E
K
V
H
A
----
K
G
K
L
T
A
R
E
R
I
Y
A
L
L
D
E
-
D
---
S
-
F
V
E
L
D
A
L
A
K
-
H
----
R
S
------
T
-------
N
F
N
LGEKRPL
G
-----
D
G
V
V
T
G
Y
G
T
I
D
G
R
D
V
C
I
F
S
Q
D
A
T
V
F
G
G
S
L
G
E
V
Y
G
E
K
I
V
K
V
Q
E
L
A
I
K
T
G
R
P
L
I
G
I
N
D
G
A
G
A
R
I
Q
E
G
V
-
V
S
L
G
L
Y
S
---
R
I
F
R
N
N
I
L
A
S
-
G
V
-
I
P
Q
I
S
L
I
M
G
A
A
A
G
G
H
V
Y
S
P
A
L
T
D
F
V
I
M
V
D
Q
-
T
S
Q
-
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
E
V
T
M
E
E
L
G
G
A
H
T
H
M
A
K
S
G
T
A
H
Y
A
A
S
G
E
Q
D
A
F
D
Y
V
R
E
L
L
S
Y
L
P
P
N
-------
N
S
T
D
A
P
-
R
Y
Q
A
A
--
A
----
P
T
G
P
I
E
E
N
--
L
T
D
E
D
L
E
L
D
T
L
I
P
D
S
P
N
Q
P
Y
D
M
H
E
V
I
T
R
L
L
D
-
D
E
F
L
E
I
Q
A
G
Y
A
Q
N
I
V
V
G
F
G
R
I
D
G
R
P
V
G
I
V
A
N
Q
P
T
H
F
A
G
C
L
D
I
N
A
S
E
K
A
A
R
F
V
R
T
C
D
C
F
N
I
P
I
V
M
L
V
D
V
P
G
F
L
P
G
T
D
Q
E
Y
N
G
I
I
R
R
G
A
K
L
L
Y
A
Y
G
E
A
T
V
P
K
I
T
V
I
T
R
K
A
Y
G
G
A
Y
C
V
M
G
S
K
D
M
G
C
D
V
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
S
--
G
A
V
G
F
V
Y
R
Q
Q
L
--
A
E
-----
A
A
A
NG
E
------
D
-
I
D
K
L
R
L
R
L
Q
Q
E
Y
E
D
T
L
V
-
N
P
-
Y
V
A
A
E
R
G
-
Y
V
D
A
V
I
P
P
S
H
T
R
G
Y
I
G
T
A
L
R
L
L
E
R
K
I
A
Q
L
P
P
K
K
H
G
N
V
P
L
25
PsiBlast_CBE
78.81
38%
-6
- C4 -
1ON9
2
12S_PROFR
E:
[21-522]
----------
E
Q
R
Q
V
I
E
A
-----
G
G
G
E
R
R
V
E
K
Q
H
S
Q
G
K
Q
T
A
R
E
R
L
N
N
L
L
D
P
-
H
---
S
-
F
D
E
V
G
A
F
R
K
-
H
----
R
T
------
T
LFGMDKA
V
V
P
-------
A
-----
D
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
----
G
K
M
F
F
A
N
V
K
L
S
-
G
V
-
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
--
K
A
H
-
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
-------
N
T
E
E
A
S
-
F
V
N
P
N
--
N
----
D
V
S
-
P
N
T
E
--
L
R
D
-------
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
--
G
A
A
N
V
I
F
R
K
E
I
KA
A
D
-----
D
P
D
--
A
------
M
-
R
A
----
E
K
I
E
E
Y
Q
N
A
-
F
-
N
T
P
Y
V
A
A
A
R
G
-
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
P
A
K
K
H
G
N
F
P
-
14
PsiBlast_PDB
78.70
38%
-4
- C4 -
1ON9
2
12S_PROFR
A:
[21-522]
----------
E
Q
R
Q
V
I
E
A
-----
G
G
G
E
R
R
V
E
K
Q
H
S
Q
G
K
Q
T
A
R
E
R
L
N
N
L
L
D
P
-
H
---
S
-
F
D
E
V
G
A
F
R
K
-
H
----
R
T
------
T
LFGMDK
A
V
V
P
-------
A
-----
D
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
----
G
K
M
F
F
A
N
V
K
L
S
-
G
V
-
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
--
K
A
H
-
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
-------
N
T
E
E
A
S
-
F
V
N
P
N
--
N
----
D
V
S
-
P
N
T
E
--
L
R
D
-------
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
--
G
A
A
N
V
I
F
R
K
E
I
K
A
A
D
-----
D
P
D
--
A
------
M
-
R
A
----
E
K
I
E
E
Y
Q
N
A
-
F
-
N
T
P
Y
V
A
A
A
R
G
-
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
P
A
K
K
H
G
N
F
P
-
27
PsiBlast_CBE
78.56
38%
-6
- C4 -
1ON9
2
12S_PROFR
B:
[21-522]
----------
E
Q
R
Q
V
I
E
A
-----
G
G
G
E
R
R
V
E
K
Q
H
S
Q
G
K
Q
T
A
R
E
R
L
N
N
L
L
D
P
-
H
---
S
-
F
D
E
V
G
A
F
R
K
-
H
----
R
T
------
T
LFGMDKA
V
V
P
-------
A
-----
D
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
----
G
K
M
F
F
A
N
V
K
L
S
-
G
V
-
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
--
K
A
H
-
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
-------
N
T
E
E
A
S
-
F
V
N
P
N
--
N
----
D
V
S
-
P
N
T
E
--
L
R
D
-------
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
--
G
A
A
N
V
I
F
R
K
E
I
KA
A
D
-----
D
P
D
--
A
------
M
-
R
A
----
E
K
I
E
E
Y
Q
N
A
-
F
-
N
T
P
Y
V
A
A
A
R
G
-
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
P
A
K
K
H
G
N
F
P
-
16
PsiBlast_PDB
78.53
38%
-37
- C5 -
3U9R
3
?
B:
[55-531]
--------------
R
I
H
E
-----
G
G
G
S
A
A
Q
A
R
H
S
A
R
G
K
L
L
V
R
E
R
I
N
R
L
L
D
P
-
G
SPF
L
-
E
L
S
A
L
A
A
H
E
-
V
----
Y
G
------
E
-------
E
V
A
-------
A
-----
A
G
I
V
A
G
I
G
R
V
E
G
V
E
C
M
I
V
G
N
D
A
T
V
K
G
G
T
Y
Y
P
L
T
V
K
K
H
L
R
A
Q
A
I
A
L
E
N
R
L
P
C
I
Y
L
V
D
S
G
G
A
N
L
P
R
Q
D
E
V
F
P
D
R
E
H
F
-
G
R
I
F
F
N
Q
A
N
M
S
-
A
R
G
I
P
Q
I
A
V
V
M
G
S
C
T
A
G
G
A
Y
V
P
A
M
S
D
E
T
V
M
V
R
E
-
Q
A
T
-
I
F
L
A
G
P
P
L
V
K
A
A
T
G
E
V
V
S
A
E
E
L
G
G
A
D
V
H
C
K
V
S
G
V
A
D
H
Y
A
E
D
D
D
H
A
L
A
I
A
R
R
C
V
A
N
L
N
W
R
-------
K
Q
G
Q
L
Q
-
C
R
A
P
R
--
A
----
P
L
Y
-
P
A
E
E
--
L
Y
G
-------
V
I
P
A
D
S
K
Q
P
Y
D
V
R
E
V
I
A
R
L
V
D
G
S
E
F
D
E
F
K
A
L
F
G
T
T
L
V
C
G
F
A
H
L
H
G
Y
P
I
A
I
L
A
N
N
-----
G
I
L
F
A
E
A
A
Q
K
G
A
H
F
I
E
L
A
C
Q
R
G
I
P
L
L
F
L
Q
N
I
T
G
F
M
V
G
Q
K
Y
E
A
G
G
I
A
K
H
G
A
K
L
V
T
A
V
A
C
A
R
V
P
K
F
T
V
L
I
G
G
S
F
G
A
G
N
Y
G
M
C
G
R
A
Y
D
P
R
F
L
W
M
W
P
N
A
R
I
G
V
M
G
G
E
QA
A
G
V
L
A
Q
V
K
R
E
Q
--
A
E
RAGQQ
L
G
V
--
E
------
E
-
E
A
K
I
K
A
P
I
L
E
Q
Y
E
H
Q
-
G
-
H
P
-
Y
Y
S
S
A
R
L
-
W
D
D
G
V
I
D
P
A
Q
T
R
E
--------------------------
29
PsiBlast_CBE
78.45
38%
-7
- C4 -
1ON3
4
12S_PROFR
E:
[21-522]
----------
E
Q
R
Q
V
I
E
A
-----
G
G
G
E
R
R
V
E
K
Q
H
S
Q
G
K
Q
T
A
R
E
R
L
N
N
L
L
D
P
-
H
---
S
-
F
D
E
V
G
A
F
R
K
-
H
----
R
T
------
T
LFGMDKA
V
V
P
-------
A
-----
D
G
V
V
T
G
R
G
T
I
L
G
R
P
V
H
A
A
S
Q
D
F
T
V
M
G
G
S
A
G
E
T
Q
S
T
K
V
V
E
T
M
E
Q
A
L
L
T
G
T
P
F
L
F
F
Y
D
S
G
G
A
R
I
Q
E
G
I
D
S
L
S
G
Y
----
G
K
M
F
F
A
N
V
K
L
S
-
G
V
-
V
P
Q
I
A
I
I
A
G
P
C
A
G
G
A
S
Y
S
P
A
L
T
D
F
I
I
M
T
K
--
K
A
H
-
M
F
I
T
G
P
Q
V
I
K
S
V
T
G
E
D
V
T
A
D
E
L
G
G
A
E
A
H
M
A
I
S
G
N
I
H
F
V
A
E
D
D
D
A
A
E
L
I
A
K
K
L
L
S
F
L
P
Q
N
-------
N
T
E
E
A
S
-
F
V
N
P
N
--
N
----
D
V
S
-
P
N
T
E
--
L
R
D
-------
I
V
P
I
D
G
K
K
G
Y
D
V
R
D
V
I
A
K
I
V
D
W
G
D
Y
L
E
V
K
A
G
Y
A
T
N
L
V
T
A
F
A
R
V
N
G
R
S
V
G
I
V
A
N
Q
P
S
V
M
S
G
C
L
D
I
N
A
S
D
K
A
A
E
F
V
N
F
C
D
S
F
N
I
P
L
V
Q
L
V
D
V
P
G
F
L
P
G
V
Q
Q
E
Y
G
G
I
I
R
H
G
A
K
M
L
Y
A
Y
S
E
A
T
V
P
K
I
T
V
V
L
R
K
A
Y
G
G
S
Y
L
A
M
C
N
R
D
L
G
A
D
A
V
Y
A
W
P
S
A
E
I
A
V
M
G
A
E
--
G
A
A
N
V
I
F
R
K
E
I
KA
A
D
-----
D
P
D
--
A
------
M
-
R
A
----
E
K
I
E
E
Y
Q
N
A
-
F
-
N
T
P
Y
V
A
A
A
R
G
-
Q
V
D
D
V
I
D
P
A
D
T
R
R
K
I
A
S
A
L
E
M
Y
A
T
K
R
Q
T
R
P
A
K
K
H
G
N
F
P
-
22
PsiBlast_CBE
77.50
38%
3
- C4 -
3IB9
3
?
B:
[24-530]
-----------
R
I
E
E
A
T
H
-----
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
-
G
SF-
V
-
E
L
D
E
F
A
R
H
R
-
S
----
T
N
------
F
-------
G
L
D
-------
A
NRPYG
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
----
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
-
G
V
-
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
-
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
NLSEPPA
F
P
E
E
A
D
-
L
A
V
T
D
--
E
----
D
A
E
-
L
D
T
-------------
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
L
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
--
G
A
V
N
I
L
H
R
R
T
I
--
A
D
-----
A
G
D
--
D
------
A
-
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
-
L
-
N
P
-
Y
T
A
A
E
R
G
-
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L
4
PsiBlast_PDB
76.75
38%
3
- C4 -
3IB9
3
?
A:
[24-530]
-----------
R
I
E
E
A
T
H
-----
A
G
S
A
R
A
V
E
K
Q
H
A
K
G
K
L
T
A
R
E
R
I
D
L
L
L
D
E
-
G
S
F
-
V
-
E
L
D
E
F
A
R
H
R
-
S
----
T
N
------
F
-------
G
L
D
-------
A
NRPYG
D
G
V
V
T
G
Y
G
T
V
D
G
R
P
V
A
V
F
S
Q
D
F
T
V
F
G
G
A
L
G
E
V
Y
G
Q
K
I
V
K
V
M
D
F
A
L
K
T
G
C
P
V
V
G
I
N
D
S
G
G
A
R
I
Q
E
G
V
A
S
L
----
G
A
Y
G
E
I
F
R
R
N
T
H
A
S
-
G
V
-
I
P
Q
I
S
L
V
V
G
P
C
A
G
G
A
V
Y
S
P
A
I
T
D
F
T
V
M
V
D
Q
-
T
S
H
-
M
F
I
T
G
P
D
V
I
K
T
V
T
G
E
D
V
G
F
E
E
L
G
G
A
R
T
H
N
S
T
S
G
V
A
H
H
M
A
G
D
E
K
D
A
V
E
Y
V
K
Q
L
L
S
Y
L
P
S
N
NLSEPPA
F
P
E
E
A
D
-
L
A
V
T
D
--
E
----
D
A
E
-
L
D
T
-------------
I
V
P
D
S
A
N
Q
P
Y
D
M
H
S
V
I
E
H
V
L
D
D
A
E
F
F
E
T
Q
P
L
F
A
P
N
I
L
T
G
F
G
R
V
E
G
R
P
V
G
I
V
A
N
Q
P
M
Q
F
A
G
C
L
D
I
T
A
S
E
K
A
A
R
F
V
R
T
C
D
A
F
N
V
P
V
L
T
F
V
D
V
P
G
F
L
P
G
V
D
Q
E
H
D
G
I
I
R
R
G
A
K
L
I
F
A
Y
A
E
A
T
V
P
L
I
T
V
I
T
R
K
A
F
G
G
A
Y
L
V
M
G
S
K
H
L
G
A
D
L
N
L
A
W
P
T
A
Q
I
A
V
M
G
A
Q
--
G
A
V
N
I
L
H
R
R
T
I
--
A
D
-----
A
G
D
--
D
------
A
-
E
A
T
R
A
R
L
I
Q
E
Y
E
D
A
L
-
L
-
N
P
-
Y
T
A
A
E
R
G
-
Y
V
D
A
V
I
M
P
S
D
T
R
R
H
I
V
R
G
L
R
Q
L
R
T
K
R
E
S
L
P
P
K
K
H
G
N
I
P
L