@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
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Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18310: (2016-06-29 )
MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGKVNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQSQFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEFLHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKKTKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGSVISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYEIQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLMVAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQLIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMKGVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVSQAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEHRNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDVPQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDVLRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPCGVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIGRADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTIDLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLEAKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTVEGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEGALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPFDLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQYKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQLDKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVLGMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNPLFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTALFEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQTLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGKRSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGEIVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQSRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQKITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSITNSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDYAVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDAMLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKTTIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQLFEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSMIASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILTIESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFNETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMIIVPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSVATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLPELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESVIRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEKLDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTADSFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEGDVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFTQNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDLKNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPKTSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISFTLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKGIDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYLTPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQSLDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISDFDDQELTEDALQEIADMLSFH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210....-...-220.......230.......240.......250.......260.......270.......280.......290.......300.....-.-.310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450...--....460..--.....470.......480.......490.......500.......510.......520.......530.......540.......550.......560.....-------..570.....-----..580.......590-...-.....600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740....-...750.......760-.....-.-.770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.--......960.......970.......980.......990.......1000......1010......1020......1030......--1040......1050......1060......1070-.-.....1080......1090.......1100......1110......1120......1130..------------....1140......1150--------------........1160......1170......1180......1190..---------...--.1200......1210......1220.....--.1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390..--------------....1400....-..1410......1420.......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600---.......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800..----....-1810......1820......1830.......1840......1850......1860....-..1870......1880......1890......1900......1910......1920.-------.....-1930......1940---..--......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040..-....2050......2060......2070......2080......2090......2100......2110......2120.-.....2130.---.....2140..-....2150.--.....2160......2170------........2180......2190......2200......2210......2220.....----.2230.....-----.--2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350--......2360......2370......2380......2390......2400......2410......2420.....----.2430..------------.----------...2440...--...2450.......-.2460.......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......-2640.------.....--2650......----..--2660........2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780.....---.2790......2800......2810.......2820.....-.2830.------..---...2840......-.2850......2860......2870......2880......2890......--2900.......2910......2920......2930......2940......2950......2960......2970---......2980......2990......3000......3010......3020......3030......3040......3050......3060......3070......3080........3090......3100......3110......3120......3130......3140......3150......3160......3170......3180......3190......3200......3210......3220......3230......3240......3250......3260......3270......3280......3290......3300......3310......3320......3330......3340......3350......3360......3370......3380......3390......3400......3410......3420......3430......3440......3450......3460......3470......3480......3490......3500......3510......3520......3530......3540......3550......3560......3570......3580......3590......3600
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTKANSIQDIY
P
L
S
Y
M
Q
E
G
M
L
F
H
S
L
L
Q
K
D
S
Q
A
Y
V
E
QA
S
F
T
I
EGKV
N
P
Q
F
F
Q
N
S
I
N
A
L
V
E
R
H
D
I
F
R
T
I
F
ISQNVS
S
P
Q
Q
V
V
L
RER
N
V
I
V
L
EED
I
T
HL
N
E
A
E
Q
S
Q
F
I
E
Q
W
K
E
KDRDRGF
H
L
Q
K
D
V
L
M
R
I
A
L
I
QTGES
Q
Y
S
C
I
W
T
F
H
H
I
M
MDG
W
C
L
S
I
V
L
K
E
F
L
H
I
Y
A
S
Y
VNASPITLEPVQ
P
Y
G
K
Y
I
K
W
L
M
E
Q
D
K
E
Q
A
V
S
Y
W
D
H
Y
LSGHEQQTVLP
K
Q
-KKT-KGKSRQ
E
H
V
T
F
S
FS
K
E
E
S
S
R
L
S
E
L
A
A
RE
E
V
T
L
S
T
I
F
H
T
I
W
G
I
L
L
Q
KYNNND
D
A
V
F
G
S
VISGRP
A
E
I
E
G
I
E
H
M
V
G
L
F
INTM
P
V
R
VQGAK-T-
P
F
L
Q
L
I
K
D
M
Q
K
D
R
L
A
A
E
AYSYHP
L
Y
E
I
Q
S
R
S
A
V
K
Q
G
L
I
D
H
I
L
V
FENY
P
V
Q
Q
E
I
Q
M
L
N
K
Q
E
H
A
S
D
L
F
Q
IH
N
F
T
VADET
N
Y
S
F
Y
L
M
VAPG
E
E
I
H
I
K
MNYDAEQH
D
R
S
F
V
L
S
V
K
E
H
L
L
N
A
V
S
Q
I
LNNPNL
P
P
E
E
I
DITT
D
T
E
K
R
Q
L
I
G
E
I--TDQT
P
V
Y
E
T
--
I
H
A
M
F
E
K
Q
A
EKTP
D
A
H
A
V
I
D
Q
A
C
S
L
T
Y
R
E
L
N
K
A
A
N
R
L
A
R
H
L
R
M
KGVVRQE
P
V
A
I
M
M
ER
S
A
A
F
I
T
G
V
L
G
I
L
KAG
G
A
I
V
PVDPHY
P
A
D
R
I
R
Y
I
L
H
DC
G
C
S
H
V
V
S
Q-------AHLPSSLED
N
-----
Y
I
I
T
H
P
E
D
I
E
SKVD--GSN-IKSVNNAD
D
L
L
Y
M
I
Y
TSGTTGKPKG
V
Q
F
E
H
R
N
M
A
N
L
L
K
F
E
YTHSGIDF
E
A
D
V
L
Q
FATP
S
F
D
V
C
Y
Q
E
I
F
S
A
L
LKG
G
T
L
H
I
V
P
E
A
I
K
R
D
V
P
Q
L
F
A
F
I
N
KHQT
N
I
V
F
L
P
T
A
F
I
K
M
I
F
S
E
R
E
L
A
NSF
P
D
G
V
K
H
L
I
AAG
E
Q
L
M
I
S
D
L
F
Q
D
V
L
R
KRG
I
-
H
LHNHYGPSE
T
H
V
V
S
T
-
Y
T
IHP-G-DPIPELPPIGKPIGC
T
D
L
Y
I
LNHQKQLQPCGVPG
E
L
Y
I
SG
A
S
V
A
R
GYVNHDKLTSDKFSSDPFKP
D
V
I
M
Y
RT
G
D
L
A
R
RLEDG
N
I
E
Y
I
GRAD
N
Q
V
K
I
R
G
Y
R
I
E
P
Q
E
I
E
V
T
L
MNHPDIS
E
A
A
I
L
I
W
QDQNG
E
H
E
L
C
A
Y
Y
CSVQKL
N
T
I
D
L
R
S
Y
M
A
S
EL
P
E
Y
MI
P
A
K
W
I
W
VDSIPLTPNGKVDRAALP--EPDASISGNPYT
A
P
R
N
L
L
E
A
K
L
S
Q
L
F
E
D
V
L
KNGHIGIQDNFFDNGG
H
S
L
K
A
T
V
L
M
S
R
I
A
K
E
F
H
V
Q
V
S
L
K
D
I
FAHP
T
V
E
G
L
A
L
I
I
R
E
--AEQN
L
Y
A
AIEPAEKRDTYPVS
S
A
Q
K
R
I
Y
V
L
Q
QLD-E-GVAYNM
P
A
V
L
E
LEGAL
D
V
-
A
K
L
S
A
V
C
K
E
L
I
S
RHEP
L
R
T
SFVSGADD
E
P
V
Q
R
I
HTEV
P
F
TLSK------------ETTIEGFVRPFDLSQA----------------P
L
F
RA
G
L
I
EVSNE
K
H
V
L
L
V
D
M
H
H
I
ISDG
V
S
V
Q
L
L
I
R
E
F
T
D
L
Y
AN---------RQL--
K
P
L
R
I
Q
Y
K
D
Y
A
V
W
Q
Q
K
FKKGDS
Y
Q
K
Q
E
T
Y
W
--
Q
Q
QFSGDL
P
I
L
ELPTDKRRPAERQFIG
G
K
V
T
F
Q
L
D
K
E
I
T
A
R
I
K
R
L
A
HKNR
S
T
L
Y
M
T
L
L
A
L
Y
S
A
F
L
S
RLSGQD
D
I
V
IGSPIAGRPH
A
D
L
E
A
V
L
G
M
F
V
N
T
L
A
LRTRPAG
N
K
T
F
E
E
F
L
K
E
V
R
Q
T
A
L
E
A
YEHQDY
P
F
E
E
L
V
D
KLG
V
Q
R
EMSRNPL
F
D
T
T
L
V
L
Q
N
M
E
Q
Q
KLK--------------MN
D
V
Q
L
Q
WNDLE-HPISKF
D
I
S
L
Y
V
TE-HDS
E
L
F
C
Q
F
EYSTAL
F
E
K
E
T
I
Q
R
W
A
S
L
F
T
T
L
V
E
HTAASPETELDNIPILT
K
E
E
E
R
D
F
I
E
S
C
H
L
F
E
ETGYSM
N
Q
T
L
H
Y
A
L
E
Q
Q
A
EKTPD
Q
A
A
V
I
FEDG
V
M
T
Y
K
E
L
N
E
Q
A
N
R
I
A
W
E
L
IGRGVKPE
T
T
V
A
I
I
GKRS
P
E
M
L
L
G
I
Y
G
I
L
KAG
G
A
YLPIDPDY
P
E
E
R
I
S
F
L
LEDSG
T
N
I
L
L
L
QSAGL----HVPEFTG
E
I
V
Y
L
NQTNSG
L
A
HRLSNP
N
V
D
V
L
PQS
L
A
Y
V
I
YTSGSTGMPK
G
V
E
I
E
H
R
S
A
V
N
F
L
N
S
L
Q
S
R
Y
QLKHS
D
M
I
M
H
KTSYSFD
A
S
I
W
E
L
F
W
WPYAG
A
S
V
Y
L
LPQGGEK
E
P
E
V
I
A
K
A
I
E
EQK
I
T
A
M
H
F
V
P
S
M
L
H
A
F
L
E
H
I
KYRSVPI
K
T
N
R
L
K
R
V
FSG
G
E
Q
L
G
T
H
L
V
S
R
F
Y
E
LLPN
V
S
ITNSYGPTE
A
T
V
E
A
A
F
FDCP
P
H
E
----
K
L
ER-IPIGKP
V
H
H
V
R
L
Y
L
LNQNQ
R
M
L
P-VGCI
G
E
L
YIAGA
G
V
A
R
GYLNRPAL
T
E
E
R
FLEDPFY-PGERMYKTG
D
V
A
R
WLPDG
N
V
E
F
LGRTD
D
Q
V
K
I
R
G
Y
RIE
P
G
E
I
E
A
A
L
R
S
I
E
G
V
R
E
A
A
V
-------
T
V
RTD-SG
E
P
E
L
C
A
Y
V
E
G-----L
Q
--
R
N
E
V
R
A
Q
L
E
R
LLPGYMV
P
A
Y
M
I
E
MEQWPVTPSGKLDRNALPAPGGAADAETYTAPR
N
V
T
E
M
K
L
S
Q
L
W
E
D
V
L
KNGPVGIHDN
F
F
DRGGH
S
L
K
A
T
A
L
V
S
R
I
T
K
E
-FDVQV
P
L
K
D
V
FAHP
T
V
E
G
L
A
T
V
I
REGTDS
P
Y
E
AIKPAEKQETYPVS
S
A
Q
K
R
I
Y
V
L
Q
QLEDGGTGYNM
P
A
V
L
E
LEGKL
N
P
-
E
R
M
D
R
A
F
Q
E
L
---
I
K
R
H
E
S
L
R
T
SF-EQDEGG
D
P
V
--
Q
R
I
H
DEVP
F
T
L
Q
T
T
V
LG--------AR
T
E
Q
E
A
A
A
A
FIKPFDLSQAP
L
F
R
A
Q
I
V
KVSDE
R
H
L
L
L
V
D
M
H
H
I
ISDG
V
S
V
N
I
L
I
Q
E
----
F
G
E
L
YNNRKL-----
P
--
A
L
R
I
Q
YK
D
Y
A
V
W
Q
E
GFKTG
D
A
Y
K
M
Q
E
A
Y
W
L
K
Q
LEGEL
P
V
LDLPADHARP
P
V
R
S
FAG
D
K
V
S
F
T
L
E
P
E
V
A
S
G
L
H
K
L
A
R
ENGS
T
L
Y
M
V
L
L
A
A
Y
T
A
F
L
S
RLSGQE
D
I
I
VGSPIAGRPH--K
D
L
E
P
I
L
G
M
F
V
N
T
L
A
LRTRPEGG
K
P
F
V
Q
Y
L
Q
E
V
R
E
T
A
L
E
A
F
EHQNY
P
F
E
E
L
V
D
K
L
E
L
T
R
DMSRNPV
F
D
A
M
L
V
V
QN----NDYE
P
L
H
------------
L
----------HDLQMK
P
A
Q
V
--
S
H
L
V
--
S
KF
D
L
T
L
Q
-ASE-GDG
N
I
H
F
L
F
EYS
T
A
L
F
E
K
T
T
I
E
R
W
A
S
H
L
T
N
V
L
S
I
IGKNP
K
V
T
L
N
H
I
DIL
T
Q
E
E
R
H
Q
L
L
N
EFNTGQANQ
Y
G
V
Q
T
I
S
Q
L
F
E
Q
Q
AARTPKA
S
A
LVSGDKT
L
T
Y
Q
E
L
D
E
W
S
N
G
I
A
R
A
L
R
SRGVKPDTP
V
G
I
M
M
H
R
S
F
S
M
I
A
S
I
L
G
VWKAG
G
C
Y
VPIDPEY
P
K
E
R
K
R
Y
I
LSDSG
T
K
L
L
M
T
INE-AD
L
G
V
------
L
ADFE--G--
E
I
L
T
I
ES----VE--E--DDKSPLPQMSSA
H
H
L
A
Y
I
I
Y
TSGTTGRPK
G
V
M
V
EHKG
I
A
N
T
L
Q
W
RRNAYAFNE
T
D
T
I
L
Q
L
F
SFS
F
D
G
F
I
T
S
M
F
T
P
L
LSG
A
K
A
V
L
L
H
E
E
E
A
K
D
I
L
A
I
K
H
Q
L
S
R
Q
R
I
T
H
M
I
I
V
P
V
L
Y
R
A
L
L
D
VVQPED
V
K
---
T
L
R
V
V
T
LAGEAA
D
R
E
L
I
A
R
S
LA-ICP
H
T
E
L
A
N
EYGPTE
N
S
V
-
A
T
T
V
M
R
------
H
M
---
E
K
Q
A
Y
-
V
SIGQPI-DG
T
Q
V
L
I
LNSNH
Q
L
Q
PIGVAG
E
L
C
IAGTGLARGYVN
L
P
E
L
T
E
R
A
FTQNPFK--PEA-
R
M
YRTGD
A
A
R
WMAD
G
T
L
E
Y
L
G
RID
D
Q
V
K
I
R
G
Y
R
V
E
T
K
E
I
E
S
V
I
R
C
I
KGVKD
A
A
V
V
A
H
V
TASGQ
T
E
L
S
A
Y
V
V
---TKPGL
S
T
N
A
V
R
S
E
L
Q
NKL
P
V
FM
H
P
A
F
I
E
K
L
DSLPLSPNGKLDRGALPKPVYNHEGERPFLP
P
S
S
K
M
E
Q
I
L
A
D
I
W
K
E
V
LGAEKIGT
A
D
S
F
F
E
LGGD
S
I
K
A
L
Q
V
S
A
R
L
H
-
R
-
I
G
K
Q
M
A
V
K
D
L
FSHP
T
I
Q
E
L
A
A
Y
I
RDSDTSSSQ
A
A
VEGDVQ
W
S
P
V
Q
K
W
F
L
S
Q
D
I
K
E
K
HHFNQ
S
V
M
L
HRSTS
V
Q
E
D
A
L
R
K
T
L
K
A
I
T
C
H
H
D
A
L
R
M
V
FTQNEQGKWDQYNRPLSHSDD
A
L
Y
G
L
Q
M
I
D
LSAPDGTDGNR
P
Y
E
P
L
I
K
R
H
V
L
D
I
Q
Q
K
MDLKNG
P
L
L
QAG
L
F
HTIDG
D
F
L
F
L
SA
H
H
L
VVDG
I
S
W
R
V
L
L
E
D
L
A
L
G
Y
RQAAGGEDIKLPPKT
S
S
F
K
A
Y
A
K
K
L
S
D
Y
A
E
S
Q
Q
L
M
K
Q
L
K
Y
W
R
E
A
E
E
YQTEALPFDQIDGTRAHEGQR
S
T
I
S
F
T
LND
K
E
T
A
A
L
L
K
DANSAYNT
D
T
Q
D
M
L
L
A
S
V
I
L
A
L
R
HWTNQ
S
A
F
K
L
S
LEGH
G
R
E
D
V
L
KGIDVS
R
T
I
G
W
F
T
A
I
Y
P
L
L
I
K
LNADLPD
S
E
E
S
M
V
H
V
L
K
T
T
K
D
T
L
R
RVPDKGFGY
G
V
I
K
Y
LTPPGKKDINFTGAPE
I
S
F
N
Y
L
GQFESGRTAEVPEEDAFSFSPLGAGGDI
S
T
TWNREQSL
D
I
S
A
I
A
AE
G
K
L
T
V
N
M
T
YDNA
R
F
Q
R
K
T
I
E
Q
L
S
E
T
C
R
Q
F
L
L
Q
L
I
E
H
CQN
K
S
E
T
E
K
T
I
SDF
D
D
Q
E
L
T
E
D
A
L
Q
E
I
A
D
M
LSFH
45
HHSearch
62.84
29%
12
- C1 -
4ZXH
3
?
A:
[11-1048]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
-
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
G
N
K
P
I
E
I
L
E
A
V
M
H
D
Y
P
L
L
R
V
S
M
P
A
N
-
D
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
I
F
S
D
ARHIE
A
S
D
L
T
Q
L
V
E
Q
D
T
K
Q
P
F
D
L
T
Q
P
----------------
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
L
---------
V
A
E
SD
A
V
N
G
I
E
F
V
Q
Y
A
D
K
Q
Q
S
S
V
I
-
D
D
T
D
E
S
L
I
F
W
--
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
R
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
K
R
D
G
S
I
N
P
L
A
Q
I
G
M
F
W
E
R
L
G
G
M
D
E
F
KELLLPIQTP
A
T
L
V
G
Q
D
L
T
L
G
S
F
P
V
R
-
Q
Q
E
G
Q
L
D
I
T
L
E
M
G
G
E
Y
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
-
Q
F
E
A
L
R
G
K
A
T
-
D
Y
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
T
Q
T
E
L
M
----
D
G
L
N
V
S
V
P
R
L
D
I
-
N
Q
A
G
--
V
V
A
L
E
Q
V
R
E
T
L
A
F
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
K
S
I
N
V
L
Q
A
T
P
A
T
W
K
M
L
L
D
S
E
W
------
S
G
N
A
G
L
T
A
L
C
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
K
V
--
G
C
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
A
A
R
I
T
D
-------
A
K
Y
-
I
D
L
G
E
P
L
A
N
T
Q
L
Y
V
L
D
E
Q
Q
R
L
V
P
-
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
L
P
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
-------
L
V
K
T
T
G
D
N
D
Q
K
L
V
A
Y
V
T
G
-----
Q
E
LD
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
I
F
E
Q
S
-
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
-
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.31
28%
25
- C1 -
4ZXI
5
?
A:
[17-1057]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
--
V
V
A
F
D
V
K
V
N
Q
-
S
L
G
N
K
P
I
E
I
L
E
A
V
M
H
D
Y
P
L
L
R
V
S
M
P
A
N
D
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
I
F
S
D
A
R
H
I
E
A
--------
S
D
L
T
Q
L
V
E
Q
D
T
K
Q
P
F
D
L
T
Q
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
L
V
A
E
S
D
A
V
-----
N
--
G
--
I
E
F
V
Q
Y
A
D
K
Q
Q
S
S
V
I
D
D
T
D
E
-
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
--
R
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
K
R
D
G
S
I
N
P
L
A
Q
I
G
M
F
W
E
R
LGGM
D
E
F
K
E
L
L
------------
L
PIQTP
A
T
L
V
G
Q
D
L
T
L
G
S
F
P
V
--
R
Q
Q
E
--
G
Q
L
D
I
T
L
E
M
G
G
E
-
Y
Q
G
E
L
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
-
A
P
D
Y
K
D
G
I
Q
F
E
A
L
R
G
K
A
T
D
Y
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
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V
P
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N
F
P
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N
I
I
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D
A
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P
K
V
I
L
T
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L
M
D
G
L
NVS
V
P
R
L
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--
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--
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V
A
L
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----
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R
--
E
----------
T
L
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M
Y
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----
K
P
K
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A
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L
L
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G
N
A
G
---
L
T
A
L
C
--
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
-
K
V
G
C
--
L
W
N
V
Y
G
P
T
E
T
T
V
-
W
S
S
A
A
R
------
I
T
---
D
A
K
-
Y
-
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L
G
E
P
L
-
A
N
T
Q
L
Y
V
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Q
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P
P
G
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L
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V
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K
T
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D
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D
Q
K
L
V
A
Y
-
V
---
T
G
Q
E
L
D
I
A
G
L
K
K
N
L
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L
P
A
Y
M
V
P
S
A
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K
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E
N
K
E
I
K
P
S
I
V
I
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.00
28%
26
- C1 -
4ZXH
3
?
A:
[17-1057]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
I
S
S
E
Q
L
G
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W
Y
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L
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V
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F
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L
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F
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D
A
R
H
I
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A
--------
S
D
L
T
Q
L
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L
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K
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F
G
L
V
A
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D
A
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-----
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--
G
--
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Y
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--
R
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A
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---
D
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-
Y
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Y
-
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---
T
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L
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K
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N
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K
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I
V
I
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.76
29%
7
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[3-1042]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
A
A
Q
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N
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P
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----
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--------------
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D
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----
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A
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---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
58.60
37%
-2
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[5-1060]
--
S
K
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Q
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Y
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P
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--
G
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----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
56.45
29%
1
- C1 -
4ZXH
3
?
A:
[11-1047]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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A
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---
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N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
56.05
38%
1
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[7-1057]
----
D
Q
V
Q
D
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A
T
A
I
D
P
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
-
H
V
D
Y
M
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
L
L
T
D
A
G
E
---
D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
-
R
K
A
L
R
I
M
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
V
V
H
D
L
P
-
D
S
I
S
S
L
P
-
I
G
K
P
I
S
N
A
S
V
Y
I
L
N
E
Q
S
Q
L
Q
P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
K
P
G
E
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
E
S
G
D
A
S
I
N
A
Y
L
V
N
R
T
Q
L
S
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
--
K
P
D
Q
D
Q
L
A
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
55.80
48%
-85
* C3 *
2JGP
5
A:
[4-520]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
A
P
R
S
V
W
E
A
R
L
A
Q
V
W
E
Q
V
L
N
V
P
Q
V
G
A
L
D
D
F
F
A
L
G
G
H
S
L
R
A
M
R
V
L
S
S
M
H
N
E
-
Y
Q
V
D
I
P
L
R
I
L
F
E
K
P
T
I
Q
E
L
A
A
F
I
E
E
T
A
K
G
N
V
F
S
I
E
P
V
Q
K
Q
A
Y
Y
P
V
S
S
A
Q
K
R
M
Y
I
L
D
Q
F
E
G
V
G
I
S
Y
N
M
P
S
T
M
L
I
E
G
K
L
E
R
-
T
R
V
E
A
A
F
Q
R
L
---
I
A
R
H
E
S
L
R
T
S
F
-
A
V
-
V
N
G
E
P
V
--
Q
N
I
H
E
D
V
P
F
A
L
A
Y
S
E
V
T
--------
E
E
E
A
R
E
L
V
S
S
L
V
Q
P
F
D
L
E
V
A
P
L
I
R
V
S
L
L
K
I
G
E
D
R
Y
V
L
F
T
D
M
H
H
S
I
S
D
G
V
S
S
G
I
L
L
A
E
----
W
V
Q
L
Y
Q
G
D
V
L
-----
P
--
E
L
R
I
Q
Y
K
D
F
A
V
W
Q
Q
E
F
S
Q
S
A
A
F
H
K
Q
E
A
Y
W
L
Q
T
F
A
D
D
I
P
V
L
N
L
P
T
D
F
T
R
P
S
T
Q
S
F
A
G
D
Q
C
T
I
G
A
G
K
A
L
T
E
G
L
H
Q
L
A
Q
A
T
G
T
T
L
Y
M
V
L
L
A
A
Y
N
V
L
L
A
K
Y
A
G
Q
E
D
I
I
V
G
T
P
I
T
G
R
S
H
--
A
D
L
E
P
I
V
G
M
F
V
N
T
L
A
M
R
N
K
P
Q
R
E
K
T
F
S
E
F
L
Q
E
V
K
Q
N
A
L
D
A
Y
G
H
Q
D
Y
P
F
E
E
L
V
E
K
L
A
I
A
R
D
L
S
R
N
P
L
F
D
T
V
F
T
F
Q
N
----
S
T
E
E
V
M
T
------------
L
----------
P
E
C
T
L
A
P
F
M
T
--
D
E
T
G
QH
A
K
F
D
L
T
F
S
-
A
T
E
-
E
R
E
E
M
T
I
G
V
E
Y
S
T
S
L
F
T
R
E
T
M
E
R
F
S
R
H
F
L
T
I
A
A
S
I
V
Q
N
P
H
I
R
L
G
E
I
D
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
54.44
32%
10
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[7-1060]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
C
L
E
E
S
M
N
V
I
---
M
D
R
Y
D
V
F
R
T
V
F
-
I
H
E
K
V
K
R
P
V
--
Q
V
V
L
K
K
R
Q
F
H
I
E
E
I
D
L
T
HLT
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
----
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
--
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
Q
----
D
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
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A
F
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A
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S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
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A
EI
K
G
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G
L
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N
V
V
P
R
R
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N
G
L
L
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L
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Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
------
Q
P
K
L
I
D
H
I
I
V
F
E
N
----
Y
P
L
Q
D
A
K
------------
N
EESSE-----
N
G
F
D
M
V
D
V
-
H
--
V
F
E
K
--
S
N
Y
D
L
N
L
M
-
A
S
--
P
G
D
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
-
A
H
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
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Y
S
G
Q
T
L
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Y
R
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L
D
E
E
A
N
R
I
A
R
R
L
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H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
H
Q
E
-
M
K
E
-
Q
------
A
A
E
L
P
YT
G
--
T
T
L
F
I
D
D
----
Q
T
--
R
FE
E
Q
A
S
D
P
A
T
A
I
D
P
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
H
V
-
D
Y
M
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
L
L
T
D
A
G
-
E
D
W
M
K
---
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
A
L
R
-
I
M
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
-
F
A
T
A
H
V
------
V
H
D
LP
D
S
I
S
S
-
L
P
I
G
K
P
I
-
S
N
A
S
V
Y
I
L
N
E
Q
S
Q
L
Q
P
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
K
--
P
G
E
-
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
E
S
G
D
A
S
I
N
A
Y
L
V
---
N
R
T
Q
L
S
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
Q
L
-
A
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
-
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
53.00
48%
-84
- C3 -
2JGP
5
A:
[1-520]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
E
Y
V
A
P
R
S
V
W
E
A
R
L
A
Q
V
W
E
Q
V
L
N
V
P
Q
V
G
A
L
D
D
F
F
A
L
G
G
H
S
L
R
A
M
R
V
L
S
S
M
H
N
E
-
Y
Q
V
D
I
P
L
R
I
L
F
E
K
P
T
I
Q
E
L
A
A
F
I
E
E
T
A
K
G
N
V
F
S
I
E
P
V
Q
K
Q
A
Y
Y
P
V
S
S
A
Q
K
R
M
Y
I
L
D
Q
F
E
G
V
G
I
S
Y
N
M
P
S
T
M
L
I
E
G
K
L
E
R
-
T
R
V
E
A
A
F
Q
R
L
---
I
A
R
H
E
S
L
R
T
S
F
-
A
V
V
-
N
G
E
P
V
--
Q
N
I
H
E
D
V
P
F
A
L
A
Y
S
E
V
T
--------
E
E
E
A
R
E
L
V
S
S
L
V
Q
P
F
D
L
E
V
A
P
L
I
R
V
S
L
L
K
I
G
E
D
R
Y
V
L
F
T
D
M
H
H
S
I
S
D
G
V
S
S
G
I
L
L
A
E
----
W
V
Q
L
Y
Q
G
D
V
L
-----
P
--
E
L
R
I
Q
Y
K
D
F
A
V
W
Q
Q
E
F
S
Q
S
A
A
F
H
K
Q
E
A
Y
W
L
Q
T
F
A
D
D
I
P
V
L
N
L
P
T
D
F
T
R
P
S
T
Q
S
F
A
G
D
Q
C
T
I
G
A
G
K
A
L
T
E
G
L
H
Q
L
A
Q
A
T
G
T
T
L
Y
M
V
L
L
A
A
Y
N
V
L
L
A
K
Y
A
G
Q
E
D
I
I
V
G
T
P
I
T
G
R
S
H
--
A
D
L
E
P
I
V
G
M
F
V
N
T
L
A
M
R
N
K
P
Q
R
E
K
T
F
S
E
F
L
Q
E
V
K
Q
N
A
L
D
A
Y
G
H
Q
D
Y
P
F
E
E
L
V
E
K
L
A
I
A
R
D
L
S
R
N
P
L
F
D
T
V
F
T
F
Q
N
----
S
T
E
E
V
M
T
------------
L
----------
P
E
C
T
L
A
P
F
M
T
DE
T
G
Q
H
--
A
K
F
D
L
T
F
S
-
A
T
E
-
E
R
E
E
M
T
I
G
V
E
Y
S
T
S
L
F
T
R
E
T
M
E
R
F
S
R
H
F
L
T
I
A
A
S
I
V
Q
N
P
H
I
R
L
G
E
I
D
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
52.32
40%
-27
- C1 -
5ES8
1
LGRA_BREPA
A:
[202-768]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
-
H
E
E
-
K
------
A
N
G
A
---
C
--
D
I
I
D
V
H
D
----
P
D
SY
S
--
E
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
Q
----
M
D
N
Q
---
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
E
--
R
-----
N
G
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
-
M
V
T
M
F
E
------
V
D
---
K
P
Y
A
N
-
I
P
I
G
K
P
I
-
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
T
---
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
E
Q
A
D
G
R
K
Y
L
V
G
Y
Y
V
---
A
P
E
E
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
----------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
-
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
49.95
40%
-20
- C1 -
1AMU
4
GRSA_ANEMI
A:
[20-530]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
Q
Y
L
F
A
V
N
N
T
K
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
L
I
H
------
N
I
Q
F
N
--
G
Q
V
E
I
F
E
E
D
T
----
I
K
--
I
--
R
E
G
T
N
L
H
V
P
S
K
S
T
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
-
V
I
T
L
P
P
T
Y
V
V
H
L
D
---
P
E
R
I
L
---
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
-
K
V
T
Y
I
---
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
------
T
K
---
E
T
I
G
H
S
V
P
I
G
A
P
I
-
Q
N
T
Q
I
Y
I
V
D
E
N
L
Q
L
K
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
--
P
G
E
-
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
D
H
Q
E
Q
P
Y
L
C
A
Y
F
V
---
S
E
K
H
I
P
L
E
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
T
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
49.91
40%
-36
- C1 -
5ES8
1
LGRA_BREPA
A:
[201-768]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
K
T
--
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
-------
A
L
H
E
E
K
A
N
G
A
C
D
---
I
I
D
V
H
D
P
D
S
Y
S
-
E
N
--
T
N
N
-
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
Q
M
------
D
N
Q
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
--
E
----
R
N
G
T
Y
-
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
-
M
F
E
V
D
-
K
---
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
-
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
E
Q
A
D
G
R
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
--
D
V
---------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
--
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
49.89
39%
-48
- C1 -
5ES8
1
LGRA_BREPA
B:
[198-770]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
I
D
K
T
--
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
-------
A
L
H
E
E
K
A
N
G
A
-----
C
D
I
I
D
V
H
D
P
D
S
Y
S
E
--
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
---
Q
M
D
N
Q
---
S
F
R
V
V
I
T
G
G
------
D
V
L
K
K
I
E
R
N
G
T
Y
-
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
--
M
F
E
V
-
D
-
K
P
Y
A
N
I
P
-
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
E
Q
A
D
G
R
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
DV
Q
A
D
A
E
L
L
--
D
Y
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
-
K
N
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
QA
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
49.28
40%
-19
- C1 -
1AMU
4
GRSA_ANEMI
B:
[20-530]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
Q
Y
L
F
A
V
N
N
T
K
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
L
I
H
------
N
-
Q
F
N
--
G
QV
E
I
F
E
E
D
T
----
I
K
--
I
--
R
E
G
T
N
L
H
V
P
S
K
S
T
D
L
A
Y
V
I
Y
T
-----
N
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
N
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
-
V
I
T
L
P
P
T
Y
V
V
H
L
D
---
P
E
R
I
L
---
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
-
K
V
T
Y
I
---
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
------
T
K
---
E
T
I
G
H
S
V
P
I
G
A
P
I
-
Q
N
T
Q
I
Y
I
V
D
E
N
L
Q
L
K
S
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
--
P
G
E
-
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
D
H
Q
E
Q
P
Y
L
C
A
Y
F
V
---
S
E
K
H
I
P
L
E
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
T
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
49.13
39%
-48
- C1 -
5ES8
1
LGRA_BREPA
A:
[198-770]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
I
D
K
T
--
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
-------
A
L
H
E
E
K
A
N
G
A
-----
C
D
I
I
D
V
H
D
P
D
S
Y
S
E
--
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
---
Q
M
D
N
Q
---
S
F
R
V
V
I
T
G
G
------
D
V
L
K
K
I
E
R
N
G
T
Y
-
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
--
M
F
E
V
-
D
-
K
P
Y
A
N
I
P
-
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
E
Q
A
D
G
R
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
DV-----------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
-
K
N
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
Q
A
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
48.83
38%
-85
- C1 -
4GR5
3
?
A:
[73-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
E
R
A
N
R
L
A
H
R
L
V
G
L
G
V
A
P
G
T
L
V
G
V
H
L
E
R
G
F
D
M
V
V
A
L
L
A
V
L
K
A
G
G
G
Y
T
M
L
D
P
Q
F
P
V
E
R
L
A
L
S
L
E
D
T
G
A
P
L
L
V
T
S
R
P
-
L
S
G
-
R
------
L
T
G
----
T
--
T
T
L
Y
V
E
D
-------------
A
G
N
L
A
T
G
V
G
P
E
D
V
A
C
V
M
F
T
S
G
S
T
G
R
P
K
G
V
M
S
P
H
R
A
L
T
G
T
Y
L
G
Q
-
D
Y
A
G
F
G
P
D
E
V
F
L
Q
C
S
P
V
S
W
D
A
F
G
L
E
L
F
G
A
L
L
F
G
A
R
C
V
L
Q
S
G
Q
-
N
P
D
P
L
E
I
G
E
L
V
A
R
H
G
V
T
M
L
Q
L
S
A
S
L
F
N
F
L
V
D
E
V
-
P
E
A
F
E
---
G
V
R
Y
A
I
T
G
G
E
P
A
S
V
P
H
V
A
K
A
R
R
-
D
H
P
A
L
R
L
G
N
G
Y
G
P
A
E
S
M
G
-
F
T
T
H
H
A
------
V
V
AGD
L
S
G
T
A
-
L
P
I
G
V
P
L
-
A
G
K
R
A
Y
V
L
D
D
D
L
K
P
A
A
N
G
A
L
G
E
L
Y
V
A
G
A
G
L
A
H
G
Y
V
S
R
P
A
L
T
A
E
R
F
V
A
D
P
F
A
GP
G
G
E
-
R
M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
47.71
25%
-59
- C1 -
4DG9
1
?
A:
[18-604]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
L
D
L
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
T
T
P
----
T
P
A
N
G
L
P
C
V
P
V
R
H
L
P
A
A
P
A
----
S
V
A
R
P
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
L
C
L
G
-
Q
S
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
-
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
T
L
V
D
L
-----
D
P
D
C
L
G
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
R
A
L
L
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
T
D
D
D
----
L
E
E
D
D
I
P
I
G
K
A
I
A
G
T
A
V
L
L
L
D
E
H
G
Q
E
I
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
R
G
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
-------
L
V
R
E
R
N
G
V
K
Q
L
L
C
A
W
T
-------
G
K
--
A
D
A
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
R
R
L
----------
E
L
D
P
D
Q
R
G
C
A
Q
L
W
S
E
L
L
G
---
C
E
V
G
A
D
F
F
L
C
G
G
N
S
L
L
A
L
Q
L
V
A
L
C
Q
S
A
G
A
G
A
N
L
G
L
A
D
L
Q
A
N
S
R
L
D
Q
F
S
R
L
L
R
S
H
G
L
A
P
E
R
L
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
47.41
38%
-36
- C1 -
4D4I
4
?
A:
[30-515]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
-
W
S
-
N
L
------
I
S
D
Y
Q
--
G
--
Q
V
I
C
L
D
S
Q
W
A
K
I
A
--
S
--
Y
S
Q
E
N
L
V
N
T
V
N
P
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
L
A
I
A
Q
Y
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
LPD
S
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
-
A
V
S
L
C
R
LSQLT
E
S
Q
---
R
N
R
T
E
-
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
L
K
T
V
P
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
F
S
--
P
S
E
-
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
-------
R
L
V
A
Y
L
V
P
HS
T
E
E
N
L
-
T
V
T
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
47.35
38%
-36
- C1 -
4D4G
4
?
A:
[30-514]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
-
W
S
-
N
L
------
I
S
D
Y
Q
--
G
--
Q
V
I
C
L
D
S
Q
W
A
K
I
A
--
S
--
Y
S
Q
E
N
L
V
N
T
V
N
P
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
F
T
K
L
A
I
A
Q
Y
Q
I
T
T
S
D
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
V
K
S
K
I
A
LPD
S
L
R
L
V
I
I
G
G
E
R
V
Q
P
E
L
V
R
M
W
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
-
A
V
S
L
C
R
LSQLT
E
S
Q
---
R
N
R
T
E
-
I
P
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
L
K
T
V
P
P
E
T
P
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
F
S
--
P
S
E
-
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
V
V
I
D
R
-------
R
L
V
A
Y
L
V
P
HS
T
E
E
N
L
-
T
V
T
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------