@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18320: (2016-06-29 )
MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQLDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKEHCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDFLHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTDQIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGSVISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYDIQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVIPGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIVSQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAVEHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEKDSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGNVEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEEEAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYNNRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRSFAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKLELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRGLLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHELNRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGVGPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSEKTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQRSVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQLKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPEVSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGELCVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQVKVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLLARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIWQEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIRKSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKKLAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQQSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTIQLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKRDSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGREHILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKYLTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMSAMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQSLTAEDLDSISSLVEEL
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......-220.-......230.......240.......250.......260.......270.......280.......290.......300..-....-.310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.....-----..570......---..580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890....-..-.900.......910--.---.---......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090.-.....1100.---.....1110..-....1120.--.....1130...-...-1140----.-------.-.-....1150......-1160----.........1170......1180......1190.....----.1200..--.----.-----.--.1210......-1220--......1230......1240......1250......1260......1270......1280....-...1290......1300......1310......1320--......1330......-------1340......1350......1360......1370......1380...----...1390..--.....1400..--------------..---..1410-..-.....-----------.1420......1430-......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600....-..1610......1620.---......--.-1630..-.--....1640......1650......1660......1670-.-..-....1680......1690......1700......1710......1720......1730......1740....----..1750-----......1760......1770......1780......1790......1800.-----....-----.--.1810--.......1820......1830...-..--...1840......1850......1860......-1870--........1880......1890......1900......1910......1920.----.....1930----....--....1940.....--.1950......1960......1970......1980......----1990..--...--.2000......2010......2020......2030......2040...--...-2050.......2060......2070..----....2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPQQPEIQDIY
P
L
S
F
M
Q
E
G
M
L
F
H
S
L
Y
D
E
Q
S
R
A
Y
F
EQA
S
F
T
I
HGQL
D
L
E
R
F
Q
K
S
M
D
A
V
F
D
R
Y
D
I
F
R
T
A
F
I
Y
KNVA
K
P
R
Q
V
V
L
KQRHC
P
I
H
I
E
D
I
S
H
L
N
E
R
D
K
E
H
C
T
E
A
F
K
E
QDKSKGFD
L
Q
T
D
V
L
M
R
I
S
I
L
KWAPD
H
Y
V
C
I
W
SH
H
H
I
L
MDGW
C
L
G
I
V
I
K
D
F
L
H
I
Y
Q
A
LGKGQLPDLPPVQ
P
Y
G
T
Y
I
K
W
L
M
Q
Q
D
R
E
E
A
A
E
Y
W
K
K
R
L
Q
H
F
E
KSTPLPKRTDQ-IPNG-TL
Q
Q
I
T
F
AIPE
K
E
T
A
E
L
Q
K
I
A
AASG
A
T
L
N
T
V
F
Q
A
L
W
G
I
M
L
Q
K
VNRSSD
A
V
F
G
S
V
ISGR
P
S
E
L
K
D
V
E
N
M
V
G
L
F
INT
I
P
I
RAQ-SDSL-
S
F
S
D
L
V
R
R
M
Q
K
D
M
N
E
A
E
AYSYFPLYD
I
Q
A
Q
S
A
L
K
Q
E
L
I
D
H
I
I
V
FENTP
T
Q
Q
E
I
E
E
L
N
QAGSFDFSVKDF
E
M
E
E
VTNY
S
C
S
V
K
VIPG
R
T
L
Y
V
R
I
H
F
QTSAYQ
P
S
M
M
S
E
I
K
D
Y
L
L
H
M
V
S
D
V
ISDPSLPV
S
K
MTLLDE
D
K
T
R
K
I
V
SQNN
R
T
V
S
VSPEA
P
T
L
H
G
L
F
E
R
Q
AAV
T
P
E
R
L
A
I
R
FSGGSL
T
Y
A
E
L
D
M
Y
A
S
R
L
A
A
H
L
A
ARGVT
N
E
S
I
V
G
V
L
SERS
P
D
M
L
I
A
V
L
A
V
L
KAGGAYLPLDPAY
P
K
E
R
L
S
Y
M
L
KDSG
A
S
L
L
L
T-----QPGC-SAPNFS---G
E
T
L
E
V
D
M
T
SL
E
C
E
E
V
K
R
H
V
SASVSDG
S
L
A
Y
V
I
Y
TSGSTGQPK
G
V
A
V
E
H
R
Q
A
V
S
F
L
T
G
M
Q
H
Q
F
RLSED
D
I
V
M
V
K
T
SFSF
D
A
S
V
W
Q
L
F
W
W
A
LSGA
S
A
Y
LLPPGWEK
D
S
A
L
I
V
Q
A
I
H
QENV
T
T
A
H
F
I
P
A
M
L
N
S
F
L
D
Q
A
E
I
E
R
L
S
D
R
T
S
L
K
R
V
FAGGEPLA
P
R
T
A
A
R
F
A
S
VLP
Q
V
S
L
I
HGYGPTE
A
T
V
D
A
A
F
Y
V
LDPERDRD
R
L
RIPIGKPVPG
A
R
L
Y
V
LDPH
L
A
VQPSGVAG
E
L
Y
I
AGAGVARGYLNRPAL
T
E
E
R
FLED
P
F
Y
L
G
E
R
M
YKTG
D
V
A
R
WLPDG
N
V
E
F
LGRTD
D
Q
V
K
I
R
G
Y
RIE
P
G
E
I
E
A
A
L
R
S
I
E
G
V
R
E
A
A
V
T
V
-RT-DSG
E
P
E
L
C
A
Y
V
E
G---L---
Q
---
R
N
E
V
R
A
Q
L
Q
R
LL
P
G
Y
MV
P
A
Y
M
I
E
MEQWPVTPSGKLDRNALPAPGGAADAETYTAPR
N
V
T
E
M
K
L
S
Q
L
W
E
D
V
L
KNGPVGIHDN
F
F
DRGGH
S
L
K
A
T
A
L
V
S
R
I
A
K
EFDVQV
P
L
K
D
V
FAHP
T
V
E
G
L
A
T
V
I
REGTDS
P
Y
E
AIKPAEKQETYPVS
S
A
Q
K
R
I
Y
V
L
Q
QLEDGGTGYNM
P
A
V
L
E
LEGKL
N
L
-
E
R
M
D
R
A
F
K
E
L
---
I
K
R
H
E
S
L
R
T
A
F
-EQDAGG
D
P
V
--
Q
R
I
H
DEVP
F
T
L
Q
-
T
T
V
-LGA-----R-------
T
-
E
-
E
E
A
A
A
A
FIKPFDLS-Q-------AP
L
F
R
A
Q
I
V
KVSDE
R
H
L
L
L
V
D
M
H
H
I
ISDG
V
S
V
N
I
L
I
R
E
----
F
G
E
L
YNN--R----K-----L--
P
A
L
R
I
Q
YK
D
Y
A
-
V
W
Q
E
--GFKTGDAYKT
Q
G
A
Y
W
L
K
Q
LEGEL
P
V
LDLPADHARP
P
M
R
S
FAGD
K
V
S
F
T
L
D
Q
E
V
T
S
G
L
Y
K
-
L
A
R
E-NGS
T
L
Y
M
V
L
L
A
A
Y
T
A
F
L
S
RLSGQE
D
I
I
VGSPIAGRPH--K
D
L
E
P
I
L
G
M
F
V
N
T
L
A
L-------RTRPEGG
K
P
F
V
Q
Y
L
Q
E
V
R
E
T
A
M
E
A
F
EHQDY
P
F
E
E
L
V
D
K
L
E
L
T
R
DMSR----N
P
L
F
D
V
-
M
F
--
V
L
QNM
D
Q
E
S
L
E
--------------
L
D
---
E
L
CL---KP-AANNG-----------HQ
T
S
K
F
D
L
T
L
Y
AQEQ-PR
G
L
L
T
F
Q
M
EFST
D
L
Y
K
K
K
T
I
E
K
W
L
Q
Y
F
N
N
M
L
L
S
I
I
KDNKAA
L
G
T
I
N
ILNED
E
A
H
Y
L
I
H
ELNRTKIDYPR
N
E
T
I
S
R
L
F
E
M
Q
A
EQTP
N
A
V
A
I
V
SD
T
Q
V
F
T
Y
E
D
L
N
S
W
A
N
Q
I
A
S
V
L
QIKGV
G
P
D
S
V
V
A
L
LTGR
T
P
E
L
I
A
G
M
L
G
I
L
KAG
G
A
Y
LPIDSNL
P
V
E
R
I
A
Y
M
LSDS
R
A
A
L
L
L
-QSEKTEK
R
L
LGI
E
--
C
E
---
Q
I
I
I
E
D
--
I
-
Q
K-QGE-A--KNVESSAGP
H
S
L
A
Y
I
I
Y
TSGSTGKPK
G
V
M
I
E
Q
R
S
V
I
-
R
-L-VK-NS
N
Y
I
T
FTPED
R
L
L
M
T
S
SIGFDVGSFE
I
F
G
P
LLN
G
A
A
L
HLS
D
Q
Q
T
F
L
D
S
H
Q
L
K
R
Y
I
E
HQG
I
T
T
I
W
L
T
S
S
L
F
N
----
H
L
T
EQ
N
-----
E
Q
T
F
S
Q
L
K
H
L
IIGGEAL
S
P
S
H
V
N
R
I
R
N
VCPE
V
S
IWNGYGPTENT
T
F
S
T
C
-
L
-----
H
I
Q
K
-----
T
--
Y
E
L
S---IPIGRPVGNS
T
A
F
I
L
NQWG--VLQ-
P
V
--
G
A
VGELCVGGD
G
V
ARGYLGRPDLTKEKFVPHPF-A--P--GD
R
L
YR
T
G
D
L
A
R
W
L
SDG
T
I
E
Y
VGRID
D
Q
V
K
V
R
G
Y
R
V
E
L
G
E
I
E
T
A
L
R
Q
ID
G
V
K
E
----
A
A
V
L
A
RT------AQTG--SK
E
L
F
G
Y
I
S
VKAG--T
N
A
E
Q
V
R
S
L
L
A
R
SLPNYM
I
P
A
Y
I
I
E
M
E
TLPLTSNGKLNRKA----LPEPDV--ASK--QTYIP
P
R
N
E
L
E
E
Q
L
A
L
I
W
Q
E
V
LG
I
Q
RIGIE
D
S
F
F
E
LGGD
S
I
K
A
L
Q
V
S
A--RLG-R-YG
L
S
L
Q
V
S
D
L
FRHPKI
K
D
L
S
P
F
I
R
K
----
S
E
R
I
I
E
QGPIQGDVP
W
T
P
V
Q
Q
W
F
F
S
Q
D
I
E
E
R
HHFNQ
S
V
M
L
F
HSGRLS
E
N
A
L
R
P
A
L
K
K
L
A
E
H
H
D
A
L
R
M
V
Y
RNDD
R
R
W
I
Q
INQGIHES
Q
L
Y
S
L
R
ISDLSQSESG
W
E
T
K
I
K
Q
E
V
A
D
L
Q
Q
SINLQEG
P
L
L
H
A
A
L
F
K
TLTG
D
Y
L
F
L
A
I
H
H
L
V
VDGV
S
W
R
I
L
L
E
D
L
S
A
G
Y
Q
Q
AAAG
Q
T
I
QLPPKTD
S
Y
Q
E
Y
A
R
R
I
Q
E
Y
A
Q
S
S
K
L
I
R
E
E
A
Y
W
R
S
V
E
E
Q
Q
A
AELPYEIP
H
H
V
N
IDFSKRD
S
L
S
F
SLTE
A
D
T
A
V
L
L
Q
NVNHAYGTD
T
Q
D
I
L
L
T
A
A
S
L
A
I
C
EWTGG
S
K
L
R
I
A
MEGHGREHILPELDI
S
R
T
V
G
W
F
T
S
M
Y
P
A
L
I
SFEN
H
R
D
E
LGT
S
V
K
T
V
K
D
T
L
GRIPNKGV
G
Y
G
M
L
K
Y
LTHPENK
S
I
T
FSKTP
E
I
S
F
N
YLGQFNDI
E
R
QDTFRPSSLGSGKD
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H
T
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I
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K
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T
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I
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L
V
E
EL
3
PsiBlast_PDB
61.51
29%
21
- C2 -
4ZXH
3
?
A:
[17-1050]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
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P
T
C
S
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M
--
V
V
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D
V
K
V
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L
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D
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L
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Y
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A
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R
H
I
-
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A
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D
-------
L
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L
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Q
-------
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C
G
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--
D
----
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--
N
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--------------
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---
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N
A
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L
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-------
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D
A
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---
I
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V
V
L
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G
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--
D
Q
K
L
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A
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V
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G
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---
L
D
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A
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L
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L
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L
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----
N
K
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.06
29%
19
- C2 -
4ZXI
5
?
A:
[17-1050]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
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P
T
C
S
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V
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I
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V
M
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V
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M
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A
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D
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P
N
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A
-
R
H
I
-
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A
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-----
D
-------
L
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Q
L
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-------
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C
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--
D
----
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--
N
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A
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A
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---
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----
K
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N
A
G
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A
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C
G
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A
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L
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A
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---
I
D
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A
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V
L
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----
A
V
V
L
V
K
T
------
T
G
D
N
--
D
Q
K
L
V
A
Y
V
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Q
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---
L
D
I
A
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L
K
K
N
L
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M
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A
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A
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K
L
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D
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A
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R
L
G
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----
N
K
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
59.82
28%
-4
- C2 -
4ZXJ
1
ENTF_ECOLI
A:
[3-1015]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
A
A
Q
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I
W
M
A
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K
L
S
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L
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L
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-
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--
Q
W
V
D
D
A
L
T
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L
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-
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I
I
D
L
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T
-----
N
-------
I
-
D
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H
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A
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A
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DLRVDSG
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-----
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D
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H
---
G
D
L
S
I
E
I
L
A
N
K
Q
R
Y
D
E
P
T
L
I
Q
H
A
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R
L
K
M
L
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A
Q
F
A
A
D
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A
L
L
C
G
D
V
D
I
M
L
P
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-
Y
A
Q
L
A
Q
L
N
A
T
Q
V
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-
T
L
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A
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A
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L
L
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-
T
T
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D
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F
S
D
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--
N
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---
T
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-
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Q
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A
--
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L
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L
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L
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M
L
A
A
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A
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L
T
P
Q
T
A
----
R
Q
S
C
A
T
L
K
Q
V
F
C
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G
E
A
L
-
P
A
D
L
C
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W
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Q
L
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L
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G
P
T
E
A
A
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D
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W
-
Y
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AFG
E
E
L
A
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-----
V
--
R
G
S
S
---
V
P
I
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Y
P
V
W
N
T
G
L
R
I
L
D
A
M
M
--
H
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-
P
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--
G
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L
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M
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H
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C
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Q
A
------
A
A
T
G
GD
A
R
Q
L
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Y
L
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G
LP
L
D
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A
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----
L
P
L
P
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L
--
K
A
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--
A
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A
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A
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L
L
A
M
K
L
A
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--
Q
L
S
-
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
57.82
37%
-0
- C2 -
2VSQ
2
SRFAC_BACSU
A:
[8-1059]
-----
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
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Q
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-
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---
G
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-
R
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---
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---
A
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A
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L
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A
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A
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N
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
56.78
37%
2
- C2 -
2VSQ
2
SRFAC_BACSU
A:
[7-1060]
----
D
Q
V
Q
D
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Y
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---
A
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P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
52.57
47%
-83
* C3 *
2JGP
5
A:
[4-520]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
A
P
R
S
V
W
E
A
R
L
A
Q
V
W
E
Q
V
L
N
V
P
Q
V
G
A
L
D
D
F
F
A
L
G
G
H
S
L
R
A
M
R
V
L
S
S
M
H
N
E
Y
Q
V
D
I
P
L
R
I
L
F
E
K
P
T
I
Q
E
L
A
A
F
I
E
E
T
A
K
G
N
V
F
S
I
E
P
V
Q
K
Q
A
Y
Y
P
V
S
S
A
Q
K
R
M
Y
I
L
D
Q
F
E
G
V
G
I
S
Y
N
M
P
S
T
M
L
I
E
G
K
L
E
R
-
T
R
V
E
A
A
F
Q
R
L
---
I
A
R
H
E
S
L
R
T
S
F
-
A
V
-
V
N
G
E
P
V
--
Q
N
I
H
E
D
V
P
F
A
L
A
-
Y
S
E
-
V
T
E
-----
E
-------
E
-
A
-
R
E
L
V
S
S
L
V
Q
P
F
D
L
E
-
V
-------
A
P
L
I
R
V
S
L
L
K
I
G
E
D
R
Y
V
L
F
T
D
M
H
H
S
I
S
D
G
V
S
S
G
I
L
L
A
E
----
W
V
Q
L
Y
Q
G
--
D
----
V
-----
L
--
P
E
L
R
I
Q
Y
K
D
F
A
-
V
W
Q
Q
--
E
F
S
Q
S
A
A
F
H
K
Q
E
A
Y
W
L
Q
T
F
A
D
D
I
P
V
L
N
L
P
T
D
F
T
R
P
S
T
Q
S
F
A
G
D
Q
C
T
I
G
A
G
K
A
L
T
E
G
L
H
Q
-
L
A
Q
A
-
T
G
T
T
L
Y
M
V
L
L
A
A
Y
N
V
L
L
A
K
Y
A
G
Q
E
D
I
I
V
G
T
P
I
T
G
R
S
H
--
A
D
L
E
P
I
V
G
M
F
V
N
T
L
A
M
-------
R
N
K
P
Q
R
E
K
T
F
S
E
F
L
Q
E
V
K
Q
N
A
L
D
A
Y
G
H
Q
D
Y
P
F
E
E
L
V
E
K
L
A
I
A
R
D
L
S
R
----
N
P
L
F
D
T
-
V
F
--
T
F
Q
N
S
T
E
E
V
M
T
--------------
L
P
---
E
C
T
L
---
A
P
F
M
T
D
E
T
-----------
G
Q
H
A
K
F
D
L
T
F
S
A
T
E
E
--
R
E
E
M
T
I
G
V
E
Y
S
T
S
L
F
T
R
E
T
M
E
R
F
S
R
H
F
L
T
I
A
A
S
I
V
Q
N
P
H
I
R
L
G
E
I
D
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
51.91
47%
-81
- C3 -
2JGP
5
A:
[1-520]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
E
Y
V
A
P
R
S
V
W
E
A
R
L
A
Q
V
W
E
Q
V
L
N
V
P
Q
V
G
A
L
D
D
F
F
A
L
G
G
H
S
L
R
A
M
R
V
L
S
S
M
H
N
E
Y
Q
V
D
I
P
L
R
I
L
F
E
K
P
T
I
Q
E
L
A
A
F
I
E
E
T
A
K
G
N
V
F
S
I
E
P
V
Q
K
Q
A
Y
Y
P
V
S
S
A
Q
K
R
M
Y
I
L
D
Q
F
E
G
V
G
I
S
Y
N
M
P
S
T
M
L
I
E
G
K
L
E
R
-
T
R
V
E
A
A
F
Q
R
L
---
I
A
R
H
E
S
L
R
T
S
F
-
A
V
V
-
N
G
E
P
V
--
Q
N
I
H
E
D
V
P
F
A
L
A
-
Y
S
E
-
V
T
E
-----
E
-------
E
-
A
-
R
E
L
V
S
S
L
V
Q
P
F
D
L
E
-
V
-------
A
P
L
I
R
V
S
L
L
K
I
G
E
D
R
Y
V
L
F
T
D
M
H
H
S
I
S
D
G
V
S
S
G
I
L
L
A
E
----
W
V
Q
L
Y
Q
G
--
D
----
V
-----
L
--
P
E
L
R
I
Q
Y
K
D
F
A
-
V
W
Q
Q
--
E
F
S
Q
S
A
A
F
H
K
Q
E
A
Y
W
L
Q
T
F
A
D
D
I
P
V
L
N
L
P
T
D
F
T
R
P
S
T
Q
S
F
A
G
D
Q
C
T
I
G
A
G
K
A
L
T
E
G
L
H
Q
-
L
A
Q
A
-
T
G
T
T
L
Y
M
V
L
L
A
A
Y
N
V
L
L
A
K
Y
A
G
Q
E
D
I
I
V
G
T
P
I
T
G
R
S
H
--
A
D
L
E
P
I
V
G
M
F
V
N
T
L
A
M
-------
R
N
K
P
Q
R
E
K
T
F
S
E
F
L
Q
E
V
K
Q
N
A
L
D
A
Y
G
H
Q
D
Y
P
F
E
E
L
V
E
K
L
A
I
A
R
D
L
S
R
----
N
P
L
F
D
T
-
V
F
--
T
F
Q
N
S
T
E
E
V
M
T
--------------
L
P
---
E
C
T
L
---
A
P
F
M
T
D
E
T
-----------
G
Q
H
A
K
F
D
L
T
F
S
A
T
E
E
-
R
E
E
-
M
T
I
G
V
E
Y
S
T
S
L
F
T
R
E
T
M
E
R
F
S
R
H
F
L
T
I
A
A
S
I
V
Q
N
P
H
I
R
L
G
E
I
D
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
51.80
28%
7
- C2 -
4ZXH
3
?
A:
[11-1047]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
G
N
K
P
I
E
I
L
E
A
V
---
M
H
D
Y
P
L
L
R
V
S
M
-
P
A
N
D
-
Q
G
I
E
--
Q
L
I
W
D
R
V
Y
P
N
I
I
-
F
S
D
-
A
R
H
-----
I
E
A
S
----
D
L
T
-
Q
L
V
E
Q
D
T
K
Q
P
F
D
L
T
-
Q
-------
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
----
V
S
K
R
F
G
L
--
V
----
A
-----
E
SD
A
V
N
G
I
E
F
V
Q
Y
A
-
D
K
Q
Q
--
S
S
V
I
-
D
D
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
-
L
A
K
D
-
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
--
R
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
-------
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
K
R
D
G
S
I
----
N
P
L
A
Q
I
-
G
M
--
F
W
E
R
L
G
G
M
D
E
F
KELLLPIQTP
A
T
L
V
G
Q
---
D
L
T
L
---
G
S
-
F
P
-
V
R
-----------
Q
Q
E
G
Q
L
D
I
T
L
E
M
G
G
E
Y
Q
G
E
L
-
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
I
Q
F
E
A
L
R
G
K
A
T
D
-
Y
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
-
T
Q
T
E
L
M
D
G
L
N
V
S
---
V
P
---
R
L
D
I
N
Q
--
A
--
G
-
V
V
A
-
L
--
E
Q
V
R
E
T
L
A
F
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
-
N
-
F
-
L
L
S
M
N
D
R
L
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
K
S
I
N
V
L
Q
A
T
P
A
T
W
K
----
M
L
L
D
S
E
------
W
S
G
N
A
G
L
T
A
L
C
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
K
V
--
G
C
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
A
-
A
-----
R
I
T
---------
D
A
K
Y
---
I
D
L
G
E
P
L
A
N
T
Q
L
Y
V
L
D
E
Q
Q
--
R
L
V
-
P
P
--
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
-
L
P-
N
--
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
----
A
V
V
L
V
K
T
------
T
G
D
N
--
D
Q
K
L
V
A
Y
V
T
G
Q
E
---
L
D
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
----
F
P
E
P
I
F
--
E
Q
S
--
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
--
H
L
K
K
A
-
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
----
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
51.28
34%
22
- C2 -
2VSQ
2
SRFAC_BACSU
A:
[8-1060]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
C
L
E
E
S
M
N
V
I
---
M
D
R
Y
D
V
F
R
T
V
F
-
I
H
E
K
V
K
R
P
V
--
Q
V
V
L
K
K
R
Q
F
H
I
E
-
E
I
D
-
L
T
H
-----
L
T
G
S
E
Q
T
A
K
-
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
-
R
-------
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
----
L
F
K
V
Y
N
A
--
L
----
R
E
Q
K
P
Y
S
--
L
P
P
V
K
P
Y
K
D
Y
I
-
K
W
L
E
--
K
Q
----
D
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
-
L
A
K
S
-
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
EI
K
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
-------
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
------
Q
----
P
K
L
I
D
H
-
I
I
--
V
F
E
N
Y
P
L
Q
D
A
K
--------------
N
E
ESS
E
N
G
F
---
D
M
-
V
D
V
H
V
-----------
F
E
K
S
N
Y
D
L
N
L
M
A
S
P
--
G
D
E
M
-
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
Q
-
A
H
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
-
T
H
Q
E
M
K
E
Q
A
A
E
L
P
YT
G
T
---
T
L
F
I
D
D
--
Q
-
T
R
F
E
E
Q
-
A
--
S
D
P
A
T
A
I
D
P
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
-
G
-
L
-
V
K
-
H
V
D
Y
M
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
----
L
L
T
D
A
G
-----
E
D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
A
L
R
I
M
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
-
H
-----
V
V
H
D
LP---
D
--
S
I
S
S
---
L
P
I
G
K
P
I
S
N
A
S
V
Y
I
L
N
E
Q
S
--
Q
L
Q
-
P
F
--
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
-
K
--
P
--
G
E
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
----
A
V
V
V
A
D
R
------
H
E
S
G
--
D
A
S
I
N
A
Y
L
V
N
R
T
Q
--
L
S
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
----
L
P
K
P
D
Q
--
D
Q
L
A
-
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
--
R
I
K
K
E
-
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
----
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
51.26
40%
-38
* C2 *
5ES8
1
LGRA_BREPA
A:
[202-768]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
-----
N
A
L
H
E
E
K
A
N
G
A
---
C
D
I
I
D
V
H
D
P
D
S
-
Y
S
E
N
T
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
Q
M
-------
D
N
Q
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
-----
E
R
-
N
G
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
D
K
----
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
-
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
-
K
E
Q
A
D
G
R
K
Y
L
V
G
Y
Y
V
A
---
P
---
E
EIP
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
---------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
50.34
42%
-33
- C2 -
5ES8
1
LGRA_BREPA
B:
[200-761]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
-
T
N
A
L
H
E
E
K
A
N
G
-
A
--
C
D
---
I
I
D
V
H
D
--
P
-
D
S
-
Y
S
E
N
T
--
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
-
N
-
F
-
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
----
Q
F
M
Q
M
D
-----
N
Q
S
F
---
R
V
V
I
T
G
G
D
V
L
K
K
I
E
R
N
G
T
------
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
-
F
-----
E
V
D
K
-----
P
--
Y
A
-
N
---
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
--
A
L
Q
-
P
I
--
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
--
Q
--
T
--
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
----
T
T
V
L
A
K
E
------
Q
A
D
G
--
R
K
Y
L
V
G
Y
Y
V
A
P
E
E
--
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
----
L
P
D
V
Q
A
--
D
A
E
LL-
D
Y
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
--
Q
L
K
-
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
49.76
39%
-100
- C2 -
4GR5
3
?
D:
[72-467]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
E
R
A
N
R
L
A
H
R
L
V
G
L
G
V
A
P
G
T
L
V
G
V
H
L
E
R
G
F
D
M
V
V
A
L
L
A
V
L
K
A
G
G
G
Y
T
M
L
D
P
Q
F
P
V
E
R
L
A
L
S
L
E
D
T
G
A
P
L
L
V
-
T
S
R
P
L
S
G
R
L
T
G
T
T
-------
T
L
Y
V
E
D
-----------
A
--
G
N
L
A
T
G
V
G
P
E
D
V
A
C
V
M
F
T
S
G
S
T
G
R
P
K
G
V
M
S
P
H
R
A
L
T
-
G
-
T
-
Y
L
-
G
Q
D
Y
A
G
F
G
P
D
E
V
F
L
Q
C
S
P
V
S
W
D
A
F
G
L
E
L
F
G
A
L
L
F
G
A
R
C
V
L
Q
S
G
Q
N
-
P
D
P
L
E
I
G
E
L
V
A
R
H
G
V
T
M
L
Q
L
S
A
S
L
F
N
----
F
L
V
D
E
V
-----
P
E
A
F
E
G
V
R
Y
A
I
T
G
G
E
P
A
S
V
P
H
V
A
K
A
R
R
D
H
P
A
L
R
L
G
N
G
Y
G
P
A
E
S
M
G
F
T
T
--
H
-----
H
A
V
V
-----
A
--
G
D
L
S
GTA
L
P
I
G
V
P
L
A
G
K
R
A
Y
V
L
D
D
----
D
L
K
-
P
A
AN
G
A
L
G
E
L
Y
V
A
G
A
G
L
A
H
G
Y
V
S
R
P
A
L
T
A
E
R
F
V
A
D
P
F
-
A
--
G
PG
G
E
R
M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
49.71
26%
-4
- C2 -
4ZXJ
1
ENTF_ECOLI
A:
[2-1041]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
V
A
A
Q
P
G
I
W
M
A
E
K
L
S
E
L
P
S
A
W
S
V
A
H
Y
V
E
L
T
G
E
V
D
S
-
P
L
L
A
R
A
V
V
A
G
---
L
A
Q
A
D
T
L
R
M
R
F
-
T
E
D
N
-
G
E
V
W
--
Q
W
V
D
D
A
L
T
F
E
L
P
E
I
I
D
-
L
R
T
NIDPH
G
-------
T
-
A
Q
A
L
M
Q
A
D
L
Q
Q
D
L
R
V
D
S
G
-------
K
P
L
V
F
H
Q
L
I
Q
V
A
D
N
R
W
Y
W
Y
Q
R
Y
H
H
L
L
V
D
G
F
S
F
P
A
I
T
R
Q
----
I
A
N
I
Y
C
T
--
W
L
R
GE
P
-----
T
P-
A
S
P
F
T
P
F
A
D
V
V
-
E
E
Y
Q
--
Q
Y
R
E
S
E
A
W
Q
R
D
A
A
F
W
A
E
Q
R
R
Q
L
P
P
P
A
S
L
S
P
A
P
L
P
G
R
S
A
S
A
D
I
L
R
L
K
L
E
F
T
D
--
G
E
F
R
Q
L
-
A
T
Q
L
-
S
G
V
Q
R
T
D
L
A
L
A
L
A
A
L
W
L
G
R
L
C
N
R
M
D
Y
A
A
G
F
I
F
M
R
R
L
G
--
S
A
A
L
T
A
T
G
P
V
L
N
V
L
P
L
-------
G
I
H
I
A
A
Q
E
T
L
P
E
L
A
T
R
L
A
A
Q
L
K
K
M
R
R
H
Q
R
Y
D
A
E
Q
I
V
R
D
S
G
R
--
A
A
G
D
----
E
P
L
F
G
P
-
V
L
--
N
I
K
V
F
D
Y
Q
L
-
D
--------------
I
P
---
D
V
Q
A
---
Q
T
-
H
--
T
L
-----------
A
T
G
P
V
N
D
L
E
L
A
L
F
P
D
V
H
G
D
L
-
S
I
E
I
L
A
N
K
Q
R
Y
D
E
P
T
L
I
Q
H
A
E
R
L
K
M
L
I
A
Q
F
A
A
D
P
A
L
L
C
G
D
V
D
I
M
L
P
G
E
Y
A
Q
-
L
A
Q
L
N
A
T
Q
V
E
-
I
P
E
T
T
L
S
A
L
V
A
E
Q
A
A
K
T
P
D
A
P
A
L
A
D
A
R
Y
L
F
S
Y
R
E
M
R
E
Q
V
V
A
L
A
N
L
L
R
E
R
G
V
K
P
G
D
S
V
A
V
A
L
P
R
S
V
F
L
T
L
A
L
H
A
I
V
E
A
G
A
A
W
L
P
L
D
T
G
Y
P
D
D
R
L
K
M
M
L
E
D
A
R
P
S
L
L
I
-
T
T
D
D
Q
L
P
R
F
S
D
V
P
N-
L
T
---
S
L
C
Y
N
A
--
P
-
L
--
T
P
Q
-
G
--
S
A
P
L
Q
L
S
Q
P
H
H
T
A
Y
I
I
F
T
S
G
S
T
G
R
P
K
G
V
M
V
G
Q
T
A
I
V
-
N
-
R
-
L
L
W
M
Q
N
H
Y
P
L
T
G
E
D
V
V
A
Q
K
T
P
C
S
F
D
V
S
V
W
E
F
F
W
P
F
I
A
G
A
K
L
V
M
A
E
P
E
A
H
R
D
P
L
A
M
Q
Q
F
F
A
E
Y
G
V
T
T
T
H
F
V
P
S
M
L
A
----
A
F
V
A
S
L
T
P
Q
T
A
R
Q
S
C
A
T
L
K
Q
V
F
C
S
G
E
A
L
P
A
D
L
C
R
E
W
Q
Q
L
T
-
G
A
P
L
H
N
L
Y
G
P
T
E
A
A
V
D
V
S
W
-
Y
-----
P
A
F
G
E
E
L
A
Q
V
--
R
G
S
S
---
V
P
I
G
Y
P
V
W
N
T
G
L
R
I
L
D
A
M
M
--
H
P
V
-
P
P
--
G
V
A
G
D
L
Y
L
T
G
I
Q
L
A
Q
G
Y
L
G
R
P
D
L
T
A
S
R
F
I
A
D
P
F
-
A
--
P
--
G
E
R
M
Y
R
T
G
D
V
A
R
W
L
D
N
G
A
V
E
Y
L
G
R
S
D
D
Q
L
K
I
R
G
Q
R
I
E
L
G
E
I
D
R
V
M
Q
A
L
P
D
V
E
Q
----
A
V
T
H
A
C
V
INQAAA
T
G
G
D
--
A
R
Q
L
V
G
Y
L
V
S
Q
S
G
LP
L
D
T
S
A
L
Q
A
Q
L
R
E
T
L
P
P
H
M
V
P
V
V
L
L
Q
L
P
Q
L
P
L
S
A
N
G
K
L
D
R
K
A
----
L
P
L
P
E
L
--
K
A
Q
--
A
P
G
R
A
P
K
A
G
S
E
T
I
I
A
A
A
F
S
S
L
L
G
C
D
V
Q
D
A
D
A
D
F
F
A
L
G
G
H
S
L
L
A
M
K
L
A
A
--
Q
L
S
R
Q
-
V
A
R
Q
V
T
P
G
Q
V
M
V
A
S
T
V
A
K
L
A
T
I
I
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
49.28
39%
-101
- C2 -
4GR5
3
?
A:
[74-467]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
E
R
A
N
R
L
A
H
R
L
V
G
L
G
V
A
P
G
T
L
V
G
V
H
L
E
R
G
F
D
M
V
V
A
L
L
A
V
L
K
A
G
G
G
Y
T
M
L
D
P
Q
F
P
V
E
R
L
A
L
S
L
E
D
T
G
A
P
L
L
V
-
T
S
R
P
L
S
G
R
L
T
G
T
----
T
---
T
L
Y
V
E
D
-----------
A
--
G
N
L
A
T
G
V
G
P
E
D
V
A
C
V
M
F
T
S
G
S
T
G
R
P
K
G
V
M
S
P
H
R
A
L
T
-
G
-
T
-
Y
L
-
G
Q
D
Y
A
G
F
G
P
D
E
V
F
L
Q
C
S
P
V
S
W
D
A
F
G
L
E
L
F
G
A
L
L
F
G
A
R
C
V
L
Q
S
G
Q
-
N
P
D
P
L
E
I
G
E
L
V
A
R
H
G
V
T
M
L
Q
L
S
A
S
L
F
N
----
F
L
V
D
E
V
-----
P
E
A
F
E
G
V
R
Y
A
I
T
G
G
E
P
A
S
V
P
H
V
A
K
A
R
R
D
H
P
A
L
R
L
G
N
G
Y
G
P
A
E
S
M
G
F
T
T
H
-
H
-----
A
V
V
A
-----
G
DL
S
G
T
A
---
L
P
I
G
V
P
L
A
G
K
R
A
Y
V
L
D
D
D
L
--
K
P
A
-
A
N
--
G
A
L
G
E
L
Y
V
A
G
A
G
L
A
H
G
Y
V
S
R
P
A
L
T
A
E
R
F
V
A
D
P
F
-
A
GP
G
--
G
E
R
M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
49.23
39%
-96
- C2 -
4GR5
2
?
C:
[72-467]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
E
R
A
N
R
L
A
H
R
L
V
G
L
G
V
A
P
G
T
L
V
G
V
H
L
E
R
G
F
D
M
V
V
A
L
L
A
V
L
K
A
G
G
G
Y
T
M
L
D
P
Q
F
P
V
E
R
L
A
L
S
L
E
D
T
G
A
P
L
L
V
-
T
S
R
P
L
S
G
R
L
T
G
T
T
-------
T
L
Y
V
E
D
---------
P
-
A
--
G
N
L
A
T
G
V
G
P
E
D
V
A
C
V
M
F
T
S
G
S
T
G
R
P
K
G
V
M
S
P
H
R
A
L
T
-
G
-
T
-
Y
L
-
G
Q
D
Y
A
G
F
G
P
D
E
V
F
L
Q
C
S
P
V
S
W
D
A
F
G
L
E
L
F
G
A
L
L
F
G
A
R
C
V
L
Q
S
G
Q
N
-
P
D
P
L
E
I
G
E
L
V
A
R
H
G
V
T
M
L
Q
L
S
A
S
L
F
N
----
F
L
V
D
E
V
-----
P
E
A
F
E
G
V
R
Y
A
I
T
G
G
E
P
A
S
V
P
H
V
A
K
A
R
R
D
H
P
A
L
R
L
G
N
G
Y
G
P
A
E
S
M
G
F
T
T
--
H
-----
H
A
V
V
-----
A
--
G
D
L
S
G
TA
L
P
I
G
V
P
L
A
G
K
R
A
Y
V
L
D
D
----
D
L
K
-
P
A
AN
G
A
L
G
E
L
Y
V
A
G
A
G
L
A
H
G
Y
V
S
R
P
A
L
T
A
E
R
F
V
A
D
P
F
-
A
--
G
PG
G
E
R
M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
49.10
42%
-32
- C2 -
5ES8
1
LGRA_BREPA
A:
[200-761]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
-
T
N
A
L
H
E
E
K
A
N
G
-
A
--
C
D
---
I
I
D
V
H
D
--
P
-
D
S
-
Y
S
E
N
T
--
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
-
N
-
F
-
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
----
Q
F
M
Q
M
D
-----
N
Q
S
F
---
R
V
V
I
T
G
G
D
V
L
K
K
I
E
R
N
G
T
------
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
-
F
-----
E
V
D
K
-----
P
--
Y
A
-
N
---
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
--
A
L
Q
-
P
I
--
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
--
Q
--
T
--
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
----
T
T
V
L
A
K
E
------
Q
A
D
G
--
R
K
Y
L
V
G
Y
Y
V
A
P
E
E
--
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
----
L
P
D
V
------------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
--
Q
L
K
-
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
48.90
42%
-28
- C2 -
1AMU
4
GRSA_ANEMI
A:
[20-530]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
Q
Y
L
F
-
A
V
N
N
T
K
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
-
T
Q
K
H
L
V
H
L
I
H
N
I
Q
--
F
N
G
Q
V
E
I
F
E
E
D
--
T
-
I
K
-
I
R
E
-
G
--
T
N
L
H
V
P
S
K
S
T
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
-
N
-
L
K
V
F
-
F
E
N
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
Y
V
V
----
H
L
---
D
-----
P
E
R
I
L
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
---
K
V
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
-----
A
T
K
E
-----
T
--
I
G
H
S
---
V
P
I
G
A
P
I
Q
N
T
Q
I
Y
I
V
D
E
N
L
--
Q
L
K
-
S
V
--
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
-
V
--
P
--
G
E
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
----
T
A
V
S
V
H
K
------
D
H
Q
E
--
Q
P
Y
L
C
A
Y
F
V
S
E
K
H
--
I
P
L
E
Q
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
----
L
P
E
P
D
L
TF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
48.65
39%
-98
- C2 -
4GR5
3
?
A:
[72-467]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
E
R
A
N
R
L
A
H
R
L
V
G
L
G
V
A
P
G
T
L
V
G
V
H
L
E
R
G
F
D
M
V
V
A
L
L
A
V
L
K
A
G
G
G
Y
T
M
L
D
P
Q
F
P
V
E
R
L
A
L
S
L
E
D
T
G
A
P
L
L
V
-
T
S
R
P
L
S
G
R
L
T
G
T
T
-------
T
L
Y
V
E
D
-----------
A
--
G
N
L
A
T
G
V
G
P
E
D
V
A
C
V
M
F
T
S
G
S
T
G
R
P
K
G
V
M
S
P
H
R
A
L
T
-
G
-
T
-
Y
L
-
G
Q
D
Y
A
G
F
G
P
D
E
V
F
L
Q
C
S
P
V
S
W
D
A
F
G
L
E
L
F
G
A
L
L
F
G
A
R
C
V
L
Q
S
G
Q
N
-
P
D
P
L
E
I
G
E
L
V
A
R
H
G
V
T
M
L
Q
L
S
A
S
L
F
N
----
F
L
V
D
E
V
-----
P
E
A
F
E
G
V
R
Y
A
I
T
G
G
E
P
A
S
V
P
H
V
A
K
A
R
R
D
H
P
A
L
R
L
G
N
G
Y
G
P
A
E
S
M
G
F
T
T
--
H
-----
H
A
V
V
-----
A
--
G
D
L
S
GTA
L
P
I
G
V
P
L
A
G
K
R
A
Y
V
L
D
D
----
D
L
K
-
P
A
AN
G
A
L
G
E
L
Y
V
A
G
A
G
L
A
H
G
Y
V
S
R
P
A
L
T
A
E
R
F
V
A
D
P
F
-
A
--
G
PG
G
E
R
M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
48.22
31%
-58
- C2 -
4DG9
1
?
A:
[24-604]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
-
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
-
D
C
S
T
T
P
T
P
A
N
G
L
P
--
C
-----
V
P
V
R
H
--
L
--
P
-
A
A
P
-
A
--
S
V
A
R
P
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
-
R
-
L
-
C
L
-
G
Q
S
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
P
-
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
----
T
L
V
D
L
D
-----
P
D
C
L
G
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
R
A
L
L
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
-
T
C
-
C
-----
H
V
V
T
-----
D
--
D
D
L
E
EDD
I
P
I
G
K
A
I
A
G
T
A
V
L
L
L
D
E
H
G
QE
I
A
E
-
P
D
--
R
A
-
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
R
G
--
R
--
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
----
C
A
L
L
V
R
-------
E
R
N
G
--
V
K
Q
L
L
C
A
W
T
G
K
A
D
--
A
S
P
Q
A
----
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
R
R
L
E
-------------
L
D
P
D
----
Q
R
G
C
A
Q
L
W
S
E
L
L
G
C
E
V
G
A
---
D
F
F
L
C
G
G
N
S
L
L
A
L
Q
L
V
A
L
C
Q
S
A
-
G
-
A
G
A
N
L
G
L
A
D
L
Q
A
N
S
R
L
D
Q
F
S
R
L
L
R
S
H
GLA
P
E
R
L
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
48.20
42%
-32
- C2 -
5ES8
1
LGRA_BREPA
A:
[202-768]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
-
T
N
A
L
H
E
E
K
A
N
G
A
---
C
D
---
I
I
D
V
H
D
--
P
D
S
Y
-
S
E
N
-
T
--
N
N
L
P
H
V
N
R
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
-
N
-
F
-
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
----
Q
F
M
Q
M
--------
D
N
Q
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
E
-----
R
-
N
G
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
-
F
-----
E
V
D
K
--------
P
Y
A
N
---
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
A
L
--
A
L
Q
-
P
I
--
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
----
T
--
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
----
T
T
V
L
A
K
E
------
Q
A
D
G
--
R
K
Y
L
V
G
Y
Y
V
A
P
E
E
--
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
----
L
P
D
V
------------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
--
Q
L
K
-
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
----
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
46.87
31%
-74
- C2 -
4DG8
3
?
A:
[24-515]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
-
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
-
D
C
S
T
T
P
T
P
A
N
G
L
P
--
C
-----
V
P
V
R
H
--
L
--
P
-
A
A
P
-
A
--
S
V
A
R
P
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
-
R
-
L
-
C
L
-
G
Q
S
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
P
-
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
----
T
L
V
D
L
D
-----
P
D
C
L
G
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
R
A
L
L
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
-
T
C
-
C
-----
H
V
V
T
-----
D
--
D
D
L
E
EDD
I
P
I
G
K
A
I
A
G
T
A
V
L
L
L
D
E
H
G
QE
I
A
E
-
P
D
--
R
A
-
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
R
G
--
R
--
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
----
C
A
L
L
V
R
-------
E
R
N
G
--
V
K
Q
L
L
C
A
W
T
G
K
A
D
--
A
S
P
Q
A
----
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
L
R
R
L
E
E
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
45.87
31%
-77
- C2 -
4DG8
3
?
A:
[26-515]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
-
D
C
S
T
T
P
T
P
A
N
G
L
----
P
---
C
V
P
V
R
H
--
L
-
P
--
A
A
P
-
A
--
S
V
A
R
P
C
F
A
A
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
-
R
-
L
-
C
L
-
G
Q
S
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
-
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
----
T
L
V
D
L
D
-----
P
D
C
L
G
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
R
A
L
L
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
-
H
-----
V
V
T
D
D
D
---
L
--
E
E
D
D
---
I
P
I
G
K
A
I
A
G
T
A
V
L
L
L
D
E
H
G
--
Q
E
I
A
E
P
--
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
-
R
G-
R
--
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
----
C
A
L
L
V
R
E
------
R
N
G
V
---
K
Q
L
L
C
A
W
T
G
K
------
A
D
A
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
----
L
L
R
R
L
E
--
E
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------