@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
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Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18330: (2016-06-29 )
MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGNLCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQEQQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILKEFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRIKRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDAVFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGYYPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNYDFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPPEEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIAHALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQAAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKGVLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDDEAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLELNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPIGAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIGRFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLPDLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEADLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVESMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRGNLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESAIETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGKELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFRGGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRPHADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDTNREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRCRFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYAAYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDIVGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKPADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISLLKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLLLKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTDLINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGELYIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQVKVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRTYLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMAEIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSARVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVLKSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAASRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVSGESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTFKDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGHGRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKGAGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPYALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSASDFTDEDLTLDELSEIMGAVNKL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320...---....330.......340........350.......360-------------........--------.370.......380.......390.......400.......410.......420.......430.......440.......450..-.-.-...460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570....---...580....--.-..590....----...600.----..----....610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730-.......740.........750.......760...--....770-.........780.......790-.-..-.....800.......810.......820.......830-.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......-960-........970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090..-.....1100......1110....-..1120......1130-..---------...------.1140..-....1150....-..-1160......1170......1180......1190......1200---..----.-----.-...1210.......1220......1230......1240......1250......1260......1270......1280.--.....1290......1300......1310-------......1320........1330......1340......1350......1360......1370......1380......1390......1400--------------......1410---.-.--.....1420......-1430.......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600-......1610---..-.--...1620......1630......1640--.......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740.........-1750.........1760......1770......1780........1790......1800....---..1810.---.....1820....-..1830......1840......1850......1860......1870..-......1880......1890......1900......1910......1920.----.....1930----.......--.1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050..-.....2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAQSAQI
Q
D
IY
P
L
S
H
M
Q
E
G
M
L
F
H
S
L
M
DFSSK
A
Y
I
E
Q
T
S
F
T
I
TG
N
L
C
V
D
S
F
Q
K
S
L
N
L
L
V
S
R
Y
D
I
F
R
T
I
F
I
K
EVPDLTGPQ
Q
V
V
LSNR
E
L
T
V
Y
R
E
D
I
S
R
L
A
D
Q
E
Q
Q
T
L
I
D
A
F
M
T
K
D
R
EKGFDLQKDP
L
M
R
L
A
L
FDRGDS
Q
Y
T
C
V
W
T
H
H
H
I
I
MDG
W
C
L
G
I
I
L
K
E
F
F
S
M
Y
D
S
LKNNSPVQLGSTV
P
Y
S
R
Y
I
E
W
LGEQ
D
Q
E
E
T
A
A
Y
W
S
E
Y
L
K
EYGNTASI
P
R
I
K
RRTADGNYKAD
Q
V
S
FSL
A
P
D
M
V
E
K
L
T
E
A
A
Q
NWG
V
T
L
N
T
L
F
M
S
I
W
G
V
L
L
H
RYNAA
D
D
A
V
F
G
S
V
ISGRP
S
A
I
D
G
I
E
S
M
V
G
L
F
INTV
P
V
R
I
RSAEGI
T
F
S
S
L
V
K
A
V
Q
E
D
---
I
LSSEQHGYY
P
L
Y
EI-QNH
S
P
L
K
Q
G
L
I
D
H
I
F
V
FENY---------------P
V
Q
L
H
Q
AL--------SVESENDEG
A
L
K
L
SDISMSEQTNY
D
F
N
I
V
I
VPGE
S
F
Y
I
K
F
SYNA
D
V
Y
E
R
E
E
M
L
R
I
Q
G
H
L
K
Q
A
L
D
C
ILTNPD
V
A
V
SDINIVPP
E
E
Q
Q
-
V
-
I
-
Q
L
F
NETERPYV
N
K
T
I
P
Q
L
F
E
E
Q
AHKTP
E
A
A
A
L
KMGNEC
W
T
Y
R
Q
L
Q
V
R
A
N
Q
I
A
H
A
L
I
E
KGVGSGD
I
V
A
V
M
MGRSMEM
P
A
A
L
L
G
I
WKAGGAYMPLDPHF
P
A
E
R
L
S
F
L
LKDS
Q
A
A
Q
L
L
I
E
E
D
L
---
I
S
LIPPSYEG--
N
-
T
I
T
I
EHTES----YQTEAPN----MP----PG
D
L
A
Y
L
I
Y
TSGTTGRPK
G
V
L
V
DHHG
I
A
N
T
L
Q
W
R
R
E
E
YSM
T
E
Q
D
I
S
L
H
L
F
S
Y
V
F
D
G
C
V
T
S
L
F
T
P
L
LSG
A
C
V
L
L
TTDD
E
A
K
D
V
L
A
L
K
R
K
I
A
R
YKV
S
H
M
I
I
V
P
S
L
Y
R
V
L
L
E
V
MTADDAK
S
L
R
I
V
T
FAGE-AV
T
P
D
L
L
E
--
L
N
Q
IICP
S
A
E
L
A
N
EYGPTE
N
S
V
A
T
T
--
I
L
R
HL---NKKE
R
I
T
IGHPIRN
T
K
V
F
V
L
-H-G-NQ-MQPIGAAG
E
L
C
ISGAGLA
R
G
Y
Y
K
Q
Q
E
L
T
Q
K
A
FSDHPFL-EG
E
R
L
Y
RTGDAGRFLPD
G
T
I
E
Y
I
GRFD
D
Q
V
K
I
R
G
Y
R
I
E
L
R
E
I
E
T
V
L
R
QAPG
V
K
E
A
A
V
L
A
RDVSAEE
K
E
L
V
A
Y
I
VPEKGNS
L
P
D
L
Y
Q
H
L
A
G
TL
P
S
Y
MI
P
A
S
I
I
N
I
SQMPLTSSGKLDRFALPEPENN
T
-
S
-
V
-
T
Y
MA
P
R
T
L
I
E
A
D
L
A
H
I
W
E
D
V
LNKQHIGI
R
D
D
F
F
Q
LG
G
Q
S
L
K
A
A
A
L
V
S
R
I
H
K
K
LNVEL
P
L
S
E
VFSYP
T
V
E
S
M
A
V
K
L
M
S
L
K
E
H
AFTQIEPADQRDVYPLSF
S
Q
K
R
L
Y
A
L
H
Q
LADDSTGYNM
P
A
V
L
E
L
RGNL
N
R
-
Q
R
-
L
R
S
V
L
T
E
L
V
N
R
H
E
A
L
R
T
V
F
V
LDR-DE
P
V
Q
I
I
Y
P
E
MAF
D
L
K
-
E
L
---------
E
M
E
------
S
E
Q
M
L
E
S
-
A
I
E
T
F
I
K
P
F
YLS-SG-P
L
F
R
A
C
V
I
T
MGNN
R
G
F
L
L
L
D
M
H
H
I
IADG
V
S
M
S
T
L
V
Q
E
F
T
D
L
YC----GK----E-----L-P
A
L
N
L
H
-
Y
K
D
F
A
V
W
Q
QEK
H
P
K
E
L
Y
K
K
Q
E
A
Y
W
L
G
Q
LGGSLP
T
L
ELPLDKTRPRLPDFRG
G
T
I
E
V
N
ID
K
D
M
A
D
E
L
H
R
L
M
A
E--TG
T
T
L
Y
M
I
L
L
A
V
Y
S
I
L
L
S
KLSGQE
D
I
V
VG-------SPAAGRP
H
--
A
D
L
E
R
V
I
G
M
F
V
N
T
L
A
MRSKPEG
H
K
T
F
S
S
Y
L
H
D
I
R
H
L
A
L
T
A
YEHQDY
P
F
E
E
L
A
D
K
LDTNREVNRNP
L
F
D
A
M
L
VLQSSED
F
R
F
E--------------VPG
L
S
ISSV----T-P--KHDI
S
K
F
D
L
T
L
H
A
E
E-H-LS
G
I
R
C
R
F
E
YSTALF
E
E
E
T
I
T
Q
W
A
S
Y
F
I
E
L
V
K
GVTAD
T
E
M
R
ISN
M
Q
LL
P
A
A
E
R
R
L
L
L
E
KM
G
Q
Y
AAYPRN
E
N
I
V
S
L
F
E
K
Q
V
A
QYP
E
H
I
A
V
V
CGHSQL
T
Y
R
D
L
N
E
K
A
E
R
A
A
A
M
L
I
K
QGVRTG
D
I
V
G
L
MLDRSP
D
M
I
I
G
V
L
S
I
L
K
AGGAYLPIDPEY
P
K
E
R
I
S
F
M
LNDSG
A
K
L
L
L
T-ERGLNKPADY---T
G
-
H
--
I
L
Y
I
DECENNSIPADV
N
I
E
E
IVTDQP---
A
Y
V
I
Y
TSGTTGQPK
G
V
I
V
E
H
R
N
V
I
S
L
L
KHQNL
P
F
E
FN
H
E
D
V
W
T
L
F
H
S
Y
CFD
F
S
V
W
E
M
F
G
A
LLNG
S
T
L
V
V
V
SKETAR
D
P
Q
A
F
R
L
L
L
K
KE
R
V
T
V
LNQTPT---
A
F
Y
G
L
M
LED-Q---NHTD
H
L
N
I
R
Y
V
I
FGGEALQ
P
G
L
L
Q
S
W
NEKY--PHT
D
L
I
N
MYGI
T
E
T
T
V
H
V
T
F
KKL
S
A
A
D
---IAKNKSN---IGR
P
L
S
T
L
Q
A
H
V
M
-
D
AHMNLQPTGVPG
E
L
Y
IG
G
E
G
V
A
RGYL
N
R
D
EL
T
A
D
R
FVSNPYL--PGD-RLYR
T
G
D
L
A
K
R
LSNG
E
L
E
Y
L
G
RI
D
E
Q
V
K
VRG
H
R
I
E
L
G
E
I
Q
A
A
L
L
QYPMI
K
E
----
A
A
V
I
TRA------DEQG
Q
T
A
--
I
Y
A
Y
M
V
I
KDQQAA
N
I
S
D
I
R
T
Y
L
K
NAL
P
D
F
ML
P
A
R
M
I
Q
IDS
I
P
V
T
VNGKLDQKALPEPEKQAYTADDIS
P
R
N
E
I
E
T
V
M
A
E
I
W
E
E
L
L
N
V
D
E
LGVSA
N
F
F
KLGGD
S
I
K
A
L
Q
V
C
A
R
L
-
K
QR-G
F
E
T
T
V
R
E
M
F
EH
Q
T
L
G
E
L
S
A
R
V
R
K
D
V
R
A
I
DQGPVEG
E
I
T
W
T
P
I
Q
Q
W
F
F
S
Q
S
L
E
S
HHFNQ
S
V
M
I
Y
R
A
E
RF
D
E
A
A
L
R
K
V
L
K
S
L
V
T
H
H
D
A
L
R
I
V
C
RHEDG
R
Q
V
Q
INRGIDLSDE
E
L
Y
A
L
E
L
FDV
K
D
S
L
T
E
A
R
N
T
I
E
E
A
A
S
R
M
Q
E
H
I
RLETGP
L
L
H
A
G
L
F
RTENG
D
H
L
F
L
T
I
H
H
L
V
V
D
A
V
S
W
R
I
L
F
E
D
F
S
T
A
Y
K
QAVSGESIKLPQKTD
S
Y
L
T
Y
S
Q
R
I
A
D
Y
S
I
S
R
Q
V
Q
R
E
A
A
Y
W
D
E
CENRHIQPIPKDNDAASNTFKD
T
E
V
I
D
F
ELSR
H
H
T
E
L
L
L
T
A
A
H
K
A
YST
E
M
N
D
I
L
L
T
A
L
G
L
A
L
Q
KWTGNN
Q
F
K
I
S
MEGHG
R
E
S
Y
L
E
DIDIS
R
T
V
G
W
F
T
S
I
Y
P
V
W
L
DMRDSDHK
D
K
E
E
R
L
G
H
L
I
K
Q
T
K
D
M
L
H
RIPHKGA
G
Y
G
V
L
K
Y
I
S
K
RWGSQKNSP
E
I
S
F
N
Y
L
G
QF
D
Q
D
I
QSN
A
F
E
VSDIKPGNEISPNWER
P
Y
A
L
DISGAVSSG
C
L
N
M
H
I
I
Y
NRFQ
F
E
E
K
T
I
Q
T
F
S
R
H
F
K
Q
T
L
E
N
I
I
E
H
CTGKENQEWSASDFTDEDL
T
L
D
E
L
S
E
I
M
G
A
VNKL
1
PsiBlast_PDB
66.59
38%
-39
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[8-1056]
-----
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
--
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
E
I
D
L
T
H
L
T
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
R
D
I
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
P
P
V
K
P
Y
K
D
Y
I
K
W
L
E
K
Q
D
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
K
D
G
-
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
A
F
T
E
L
A
K
S
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
E
I
K
G
V
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H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
E
Q
---
S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
-
Q
S
Q
A
D
-
Q
P
K
L
I
D
H
I
I
V
F
E
N
Y
---------------
P
L
Q
D
A
K
------------
N
E
E
S
S
E
N
G
F
D
M
V
D
V
H
V
F
E
K
S
N
Y
D
L
N
L
M
A
S
P
G
D
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
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Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
-
L
-
T
G
L
N
P
P
A
Q
A
H
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T
K
P
L
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Y
W
F
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A
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Y
R
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L
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N
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M
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A
A
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L
L
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A
A
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P
--
Y
T
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--
T
-
T
L
F
I
D
D
Q
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R
----
F
E
E
Q
A
S
D
PA
T
A
I
D
----
P
N
D
P
A
Y
I
M
Y
T
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G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
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-
H
V
D
Y
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A
F
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L
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N
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A
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A
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M
L
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A
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A
D
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H
T
L
L
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R
L
T
D
L
I
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N
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N
V
M
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A
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T
A
L
F
N
L
L
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A
-
G
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D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
--
A
L
R
I
M
G
P
-
G
K
L
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N
C
Y
G
P
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T
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F
A
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V
H
D
L
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D
S
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S
L
P
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G
K
P
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A
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V
Y
I
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-
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Q
-
S
Q
-
L
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P
F
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A
V
G
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L
C
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G
M
G
V
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K
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V
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A
D
L
T
K
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K
F
I
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P
F
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-
P
G
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L
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W
L
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A
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K
Q
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P
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D
A
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A
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I
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A
Y
L
V
N
R
T
Q
L
S
A
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D
V
K
A
H
L
K
K
Q
L
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A
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M
V
P
Q
T
F
T
F
L
D
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L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
Q
L
A
-
E
-
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W
I
G
P
R
N
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M
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A
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Q
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F
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A
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G
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A
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K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
63.05
37%
-21
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[7-1060]
----
D
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
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C
L
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D
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D
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F
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F
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H
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K
V
--
K
R
P
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V
V
L
K
K
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Q
F
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K
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D
K
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P
M
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A
A
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F
K
K
A
E
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F
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W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
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Y
N
A
L
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P
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P
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L
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Y
W
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Y
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G
F
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Q
T
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A
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K
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-
Q
K
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Q
S
Q
-
A
D
----
Q
P
K
L
I
D
H
I
I
V
F
E
N
Y
---------------
P
L
Q
D
A
K
N
E
------------
E
S
S
E
N
G
F
D
M
V
D
V
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V
F
E
K
S
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Y
D
L
N
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P
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L
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L
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D
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R
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-
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L
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P
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L
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Y
M
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A
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S
A
A
A
C
L
L
T
H
Q
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M
---
K
E
Q
A
A
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L
P
Y
T
--
G
T
T
L
F
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D
Q
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R
FEEQ
A
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D
P
A
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A
----
I
D
----
P
N
D
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K
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A
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L
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L
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A
L
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T
D
A
G
-
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D
W
M
K
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R
C
I
L
F
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E
-
R
A
S
V
P
H
V
R
--
K
A
L
R
I
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K
L
I
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G
P
T
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G
T
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A
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A
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V
V
H
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D
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I
S
S
L
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K
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A
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Y
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N
-
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Q
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P
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G
M
G
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V
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A
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F
I
E
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P
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W
L
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A
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L
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L
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D
A
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V
A
D
R
H
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D
A
S
I
N
A
Y
L
V
N
R
T
Q
L
S
A
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D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
Q
-
L
A
E
-
E
W
I
G
P
R
N
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E
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T
I
A
Q
I
W
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L
G
R
K
Q
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D
D
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G
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A
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A
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K
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T
I
A
G
I
S
A
Y
L
K
N
G
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.14
26%
0
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[3-1036]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
A
A
Q
P
G
I
W
M
A
E
K
L
S
E
L
P
S
A
W
S
V
A
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Y
V
E
L
T
G
E
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D
S
-
P
L
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L
A
R
A
V
V
A
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L
A
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L
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M
R
F
T
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N
-
G
E
V
W
Q
W
V
D
D
A
L
T
F
E
L
P
-
E
I
I
DLRTNIDP
H
G
T
------
A
Q
A
L
M
Q
A
-
D
L
Q
Q
D
L
R
---
V
D
-
S
G
K
P
L
V
F
H
Q
L
I
Q
V
A
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N
R
W
Y
W
Y
Q
R
Y
H
H
L
L
V
D
G
F
S
F
P
A
I
T
R
Q
I
A
N
I
Y
C
T
W
L
R
G
E
----
P
-----
T
-
P
A
S
P
F
T
P
F
A
D
V
V
E
E
Y
Q
Q
Y
R
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A
W
Q
R
D
A
A
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W
A
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Q
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Q
L
P
P
P
A
S
L
S
P
A
P
L
P
G
R
----
S
A
S
A
D
I
L
R
L
K
L
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F
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D
G
E
F
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Q
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A
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A
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A
A
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W
L
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R
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C
N
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D
Y
A
A
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F
I
F
MRRL
G
S
A
A
L
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A
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--
G
P
V
L
N
V
L
P
L
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I
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A
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H
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--------------
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V
Q
A
Q
T
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----
T
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T
G
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D
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L
A
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C
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A
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A
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A
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T
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A
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A
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D
A
R
Y
L
F
S
Y
R
E
M
R
E
Q
V
V
A
L
A
N
L
L
R
E
R
G
V
K
P
G
D
S
V
A
V
A
L
P
R
S
V
F
L
T
L
A
L
H
A
I
V
E
A
G
A
A
W
L
P
L
D
T
G
Y
P
D
D
R
L
K
M
M
L
E
D
A
R
P
S
L
L
I
T
T
D
D
Q
L
P
R
F
S
D
V
---
P
N
------
L
T
S
L
C
Y
N
A
P
L
T
P
Q
G
S
-
A
P
L
Q
L
S
Q
P
HHT
A
Y
I
I
F
T
S
G
S
T
G
R
P
K
G
V
M
V
G
Q
T
A
I
V
N
R
L
L
W
M
Q
N
H
Y
P
L
T
G
E
D
V
V
A
Q
K
T
P
C
S
F
D
V
S
V
W
E
F
F
W
P
F
I
A
G
A
K
L
V
M
A
E
P
E
A
H
R
D
P
L
A
M
Q
Q
F
F
A
E
Y
G
V
T
T
T
H
F
V
P
S
M
L
A
A
F
V
A
S
L
T
P
Q
-
T
---
A
R
Q
S
C
A
T
L
K
Q
V
F
C
S
G
E
A
L
P
A
D
L
C
R
E
W
-
Q
Q
L
--
T
G
A
P
L
H
N
L
Y
G
P
T
E
A
A
V
D
V
S
W
Y
P
A
F
G
E
E
---
L
A
Q
V
R
G
S
SVP
I
G
Y
P
V
W
N
T
G
L
R
I
L
-
D
A
M
M
H
P
V
P
P
G
V
A
G
D
L
Y
L
T
G
I
Q
L
A
Q
G
Y
L
G
R
P
D
L
T
A
S
R
F
I
A
D
P
F
A
--
P
G
E
-
R
M
Y
R
T
G
D
V
A
R
W
L
D
N
G
A
V
E
Y
L
G
R
S
D
D
Q
L
K
I
R
G
Q
R
I
E
L
G
E
I
D
R
V
M
Q
A
L
P
D
V
E
Q
A
V
T
H
A
C
V
I
N
Q
A
------
A
A
T
G
G
D
A
R
Q
L
V
G
Y
L
V
S
Q
S
G
L
P
L
D
T
S
A
L
Q
A
Q
L
R
E
T
L
P
P
H
M
V
P
V
V
L
L
Q
L
P
Q
L
P
L
S
A
N
G
K
L
D
R
K
A
L
P
L
P
E
L
K
A
-
Q
A
P
G
R
A
P
K
A
G
S
E
T
I
I
A
A
A
F
S
S
L
L
G
C
D
V
Q
D
A
D
A
D
F
F
A
L
G
G
H
S
L
L
A
M
K
L
A
A
Q
L
S
R
Q
V
-
A
R
Q
V
T
P
G
Q
V
M
V
A
S
T
V
A
K
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
58.07
42%
-98
- C1 -
2JGP
5
A:
[4-520]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
A
P
R
S
V
W
E
A
R
L
A
Q
V
W
E
Q
V
L
N
V
P
Q
V
G
A
L
D
D
F
F
A
L
G
G
H
S
L
R
A
M
R
V
L
S
S
M
H
N
E
Y
Q
V
D
I
P
L
R
I
L
F
E
K
P
T
I
Q
E
L
A
A
F
I
E
E
T
A
K
G
N
V
F
S
I
E
P
V
Q
K
Q
A
Y
Y
P
V
S
S
A
Q
K
R
M
Y
I
L
D
Q
F
E
G
V
G
I
S
Y
N
M
P
S
T
M
L
I
E
G
K
L
E
R
-
T
R
-
V
E
A
A
F
Q
R
L
I
A
R
H
E
S
L
R
T
S
F
A
V
V
N
-
G
E
P
V
Q
N
I
H
E
D
V
P
F
A
L
A
-
Y
S
---------
E
V
T
------
E
E
E
A
R
E
--
L
V
S
S
L
V
Q
P
F
D
L
E
-
V
A
-
P
L
I
R
V
S
L
L
K
I
G
E
D
R
Y
V
L
F
T
D
M
H
H
S
I
S
D
G
V
S
S
G
I
L
L
A
E
W
V
Q
L
Y
Q
----
G
D
----
V
-----
L
-
P
E
L
R
I
Q
-
Y
K
D
F
A
V
W
Q
Q
E
F
S
Q
S
A
A
F
H
K
Q
E
A
Y
W
L
Q
T
F
A
D
D
I
P
V
L
N
L
P
T
D
F
T
R
P
S
T
Q
S
F
A
G
D
Q
C
T
I
G
A
G
K
A
L
T
E
G
L
H
Q
L
A
Q
A
--
T
G
T
T
L
Y
M
V
L
L
A
A
Y
N
V
L
L
A
K
Y
A
G
Q
E
D
I
I
V
G
-------
T
P
I
T
G
R
S
H
--
A
D
L
E
P
I
V
G
M
F
V
N
T
L
A
M
R
N
K
P
Q
R
E
K
T
F
S
E
F
L
Q
E
V
K
Q
N
A
L
D
A
Y
G
H
Q
D
Y
P
F
E
E
L
V
E
K
L
A
I
A
R
D
L
S
R
N
P
L
F
D
T
V
F
T
F
Q
N
S
T
E
E
V
M
T
--------------
L
P
E
C
T
L
A
P
F
M
TDE
T
-
G
--
Q
H
--
A
K
F
D
L
T
F
S
A
T
E
-
E
-
R
E
E
M
T
I
G
V
E
Y
S
T
S
L
F
T
R
E
T
M
E
R
F
S
R
H
F
L
T
I
A
A
S
I
V
Q
N
P
H
I
R
L
G
E
I
D
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
56.87
41%
-96
- C1 -
2JGP
5
A:
[1-520]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
S
-
E
Y
V
A
P
R
S
V
W
E
A
R
L
A
Q
V
W
E
Q
V
L
N
V
P
Q
V
G
A
L
D
D
F
F
A
L
G
G
H
S
L
R
A
M
R
V
L
S
S
M
H
N
E
Y
Q
V
D
I
P
L
R
I
L
F
E
K
P
T
I
Q
E
L
A
A
F
I
E
E
T
A
K
G
N
V
F
S
I
E
P
V
Q
K
Q
A
Y
Y
P
V
S
S
A
Q
K
R
M
Y
I
L
D
Q
F
E
G
V
G
I
S
Y
N
M
P
S
T
M
L
I
E
G
K
L
E
R
-
T
R
-
V
E
A
A
F
Q
R
L
I
A
R
H
E
S
L
R
T
S
F
A
V
V
N
-
G
E
P
V
Q
N
I
H
E
D
V
P
F
A
L
A
-
Y
S
---------
E
V
-------
T
E
E
E
A
R
E
-
L
V
S
S
L
V
Q
P
F
D
L
E
-
V
A
-
P
L
I
R
V
S
L
L
K
I
G
E
D
R
Y
V
L
F
T
D
M
H
H
S
I
S
D
G
V
S
S
G
I
L
L
A
E
W
V
Q
L
Y
Q
----
G
D
----
V
-----
L
-
P
E
L
R
I
Q
-
Y
K
D
F
A
V
W
Q
Q
E
F
S
Q
S
A
A
F
H
K
Q
E
A
Y
W
L
Q
T
F
A
D
D
I
P
V
L
N
L
P
T
D
F
T
R
P
S
T
Q
S
F
A
G
D
Q
C
T
I
G
A
G
K
A
L
T
E
G
L
H
Q
L
A
Q
A
--
T
G
T
T
L
Y
M
V
L
L
A
A
Y
N
V
L
L
A
K
Y
A
G
Q
E
D
I
I
V
G
-------
T
P
I
T
G
R
S
H
--
A
D
L
E
P
I
V
G
M
F
V
N
T
L
A
M
R
N
K
P
Q
R
E
K
T
F
S
E
F
L
Q
E
V
K
Q
N
A
L
D
A
Y
G
H
Q
D
Y
P
F
E
E
L
V
E
K
L
A
I
A
R
D
L
S
R
N
P
L
F
D
T
V
F
T
F
Q
N
S
T
E
E
V
M
T
--------------
L
P
E
C
T
L
A
P
F
----
M
-
T
DE
T
G
Q
H
A
K
F
D
L
T
F
S
A
T
E
-
E
-
R
E
E
M
T
I
G
V
E
Y
S
T
S
L
F
T
R
E
T
M
E
R
F
S
R
H
F
L
T
I
A
A
S
I
V
Q
N
P
H
I
R
L
G
E
I
D
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
56.04
37%
-96
- C1 -
5ES8
1
LGRA_BREPA
A:
[202-767]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
-
N
A
L
H
E
E
K
A
N
G
---
A
C
-
D
--
I
I
D
V
H
D
P
D
S
Y
S
E
N
T
N
N
L
P
H
V
N
R
P
D
D
L
---
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
---
A
A
E
Q
F
M
Q
M
---------
D
N
Q
S
F
R
V
V
I
T
G
G
D
V
L
K
K
I
E
-----
R
-
N
--
G
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
M
F
E
V
D
K
P
-----
Y
-
A
N
I
P
---
I
G
K
P
I
D
R
T
R
I
L
I
L
-
D
E
A
L
A
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
---
T
G
E
-
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
----
T
T
V
L
A
K
E
------
Q
A
D
G
R
K
Y
--
L
V
G
Y
Y
V
A
P
E
--
E
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
---------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
-
K
N
I
-
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
53.43
38%
-56
- C1 -
3VNQ
1
?
A:
[33-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
S
D
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
A
S
A
L
I
G
-
E
P
H
E
G
C
A
V
T
R
---
V
V
-
R
--
T
A
A
V
A
E
C
K
D
A
E
------
A
P
G
P
G
A
E
D
M
---
A
Y
V
I
Y
T
S
G
T
T
G
N
P
K
G
V
P
V
R
H
A
N
V
L
A
L
L
A
G
A
P
S
V
F
D
F
S
G
D
D
R
W
L
L
F
H
S
L
S
F
D
F
S
V
W
E
I
W
G
A
F
S
T
G
A
E
L
V
V
L
P
H
W
A
A
R
T
P
E
Q
Y
L
A
V
I
I
D
R
G
V
T
V
I
N
Q
T
P
T
---
A
F
L
A
L
T
E
A
A
V
R
---
G
G
R
D
V
S
G
L
R
Y
V
I
F
G
G
E
K
L
T
A
P
M
L
R
P
W
A
K
A
F
GL
D
R
P
R
L
V
N
G
Y
G
I
T
E
T
T
V
F
T
T
F
E
E
I
T
E
A
Y
---
L
A
Q
D
A
S
I
---
I
G
R
A
L
P
S
F
G
T
R
V
V
G
D
D
G
R
D
V
A
P
-
G
E
T
G
E
L
W
L
S
G
A
Q
L
A
E
G
Y
L
R
R
P
E
L
T
A
E
K
F
---
P
E
V
-----V
R
Y
Y
R
T
G
D
L
V
S
E
L
P
D
G
R
F
A
Y
E
G
R
A
D
L
Q
I
K
L
R
G
Y
R
I
E
L
S
D
I
E
T
A
V
R
R
H
D
D
V
V
D
----
A
V
V
T
V
R
E
------
F
K
P
G
D
L
R
--
L
V
C
A
Y
V
A
R
E
G
S
A
T
T
A
R
E
L
R
N
H
I
K
T
L
L
P
A
Y
M
H
P
A
R
Y
L
P
L
P
G
L
P
R
T
V
N
G
K
V
D
R
A
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
53.09
38%
-61
- C1 -
3VNS
2
?
A:
[33-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
S
D
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
A
S
A
L
I
G
-
E
P
H
E
G
C
A
V
T
R
---
V
V
-
R
--
T
A
A
V
A
E
C
K
D
A
E
P
-----
A
P
G
P
G
A
E
D
M
---
A
Y
V
I
Y
T
S
G
-
T
G
N
P
K
G
V
P
V
R
H
A
N
V
L
A
L
L
A
G
A
P
S
V
F
D
F
S
G
D
D
R
W
L
L
F
H
S
L
S
F
D
F
S
V
W
E
I
W
G
A
F
S
T
G
A
E
L
V
V
L
P
H
W
A
A
R
T
P
E
Q
Y
L
A
V
I
I
D
R
G
V
T
V
I
N
Q
T
P
T
---
A
F
L
A
L
T
E
A
A
V
R
---
G
G
R
D
V
S
G
L
R
Y
V
I
F
G
G
E
K
L
T
A
P
M
L
R
P
W
A
K
A
F
GL
D
R
P
R
L
V
N
G
Y
G
I
T
E
T
T
V
F
T
T
F
E
E
I
T
E
A
Y
---
L
A
Q
D
A
S
I
---
I
G
R
A
L
P
S
F
G
T
R
V
V
G
D
D
G
R
D
V
A
P
-
G
E
T
G
E
L
W
L
S
G
A
Q
L
A
E
G
Y
L
R
R
P
E
L
T
A
E
K
F
---
P
E
V
-----V
R
Y
Y
R
T
G
D
L
V
S
E
L
P
D
G
R
F
A
Y
E
G
R
A
D
L
Q
I
K
L
R
G
Y
R
I
E
L
S
D
I
E
T
A
V
R
R
H
D
D
V
V
D
----
A
V
V
T
V
R
E
------
F
K
P
G
D
L
R
--
L
V
C
A
Y
V
A
R
E
G
S
A
T
T
A
R
E
L
R
N
H
I
K
T
L
L
P
A
Y
M
H
P
A
R
Y
L
P
L
P
G
L
P
R
T
V
N
G
K
V
D
R
A
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
52.93
28%
-24
- C1 -
4ZXH
3
?
A:
[110-1096]
-------------------------------------------------------------------------------------------------------------
L
V
E
Q
D
T
K
Q
P
F
D
L
T
Q
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
L
V
A
E
S
D
A
V
N
G
I
E
F
V
Q
Y
A
D
K
Q
Q
S
S
V
I
D
D
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
R
--
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
---
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
K
R
D
G
S
I
N
P
L
A
Q
I
G
M
F
W
E
R
L
G
GMDEFKELLL
P
I
Q
T
P
A
T
L
V
G
QD
L
T
L
G
S
F
P
V
R
Q
Q
E
G
Q
L
---
D
I
T
L
E
M
G
G
E
Y
Q
G
E
L
V
G
V
--------
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
-
I
Q
F
-
E
A
L
R
G
K
A
T
D
Y
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
T
Q
T
E
L
---
M
D
G
L
N
V
S
V
P
R
--
L
-
D
I
N
Q
A
G
V
V
A
----
L
E
Q
V
R
E
T
----
L
A
----
F
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
K
S
I
N
V
L
Q
A
T
P
A
T
W
K
M
L
L
D
S
E
W
S
G
N
A
G
L
T
A
L
C
--
G
G
E
-
A
L
D
T
I
L
A
E
K
L
L
G
K
V
G
C
----
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
--
A
A
R
I
T
---
D
A
K
-
Y
I
D
L
G
E
P
L
A
N
T
Q
L
Y
V
L
-
D
-
E
-
Q
Q
R
L
V
P
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
P
S
L
P
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
L
V
K
T
T
G
D
N
D
Q
K
L
V
A
Y
V
T
G
Q
E
L
D
-
I
A
G
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
I
F
E
Q
-
S
-
N
-
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
K
E
-----
I
K
P
S
I
V
I
E
L
R
R
G
T
Y
E
Q
P
-
L
W
L
F
H
P
I
G
G
S
T
F
C
Y
-----
M
E
L
S
R
H
L
N
P
-
N
R
T
L
R
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
52.89
38%
-7
- C1 -
5ES8
1
LGRA_BREPA
A:
[198-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
-
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
-------
A
L
H
E
E
K
A
N
G
A
C
D
-
I
I
D
V
H
D
P
D
S
----
Y
S
E
N
T
N
N
----
L
P
HVNR
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
----
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
Q
M
D
N
Q
S
F
R
V
V
I
T
G
G
D
-
V
L
K
K
--
I
E
--
R
N
G
----
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
--
M
F
E
V
D
---
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
D
E
-
A
-
L
A
-
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
-
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
E
Q
A
D
G
R
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
-----------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
-
K
N
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
52.85
37%
-24
- C1 -
5ES8
1
LGRA_BREPA
A:
[203-768]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
---
E
E
K
A
N
G
A
C
D
-----
I
I
D
V
H
D
P
D
S
YSEN
T
N
N
L
P
H
V
----
N
R
----
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
F
C
E
W
Y
R
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
Y
L
P
T
G
A
A
E
Q
F
M
Q
----
M
D
N
Q
S
F
R
V
V
I
T
G
G
D
-
V
L
K
K
I
E
-------
R
-
N
G
T
Y
K
L
Y
N
G
Y
G
P
T
E
C
T
I
M
V
T
--
M
F
E
V
D
---
K
P
Y
A
N
I
P
I
G
K
P
I
D
R
T
R
I
L
I
L
-
D
-
E
A
L
A
-
L
Q
P
I
G
V
A
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
--
T
G
E
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
T
V
L
A
K
E
Q
A
D
G
R
K
Y
L
V
G
Y
Y
V
A
P
E
E
I
P
H
G
E
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
-----------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
-
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
52.75
28%
-25
- C1 -
4ZXI
5
?
A:
[110-1096]
-------------------------------------------------------------------------------------------------------------
L
V
E
Q
D
T
K
Q
P
F
D
L
T
Q
P
P
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
L
V
A
E
S
D
A
V
N
G
I
E
F
V
Q
Y
A
D
K
Q
Q
S
S
V
I
D
D
T
D
E
S
L
I
F
W
K
N
A
L
K
H
A
P
H
V
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
S
L
V
F
R
V
S
E
S
V
S
S
G
L
V
N
L
A
K
D
Y
E
I
T
L
F
G
L
V
L
S
G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
R
--
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
H
M
D
I
D
A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
E
Q
---
L
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
E
A
V
S
P
K
R
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G
S
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P
L
A
Q
I
G
M
F
W
E
RLGGMDEFKELLL
P
I
Q
T
P
A
T
L
V
G
QD
L
T
L
G
S
F
P
V
R
Q
Q
E
G
Q
L
---
D
I
T
L
E
M
G
G
E
Y
Q
G
E
L
V
G
V
--------
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
E
M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
-
I
Q
F
-
E
A
L
R
G
K
A
T
D
Y
A
Q
H
D
L
F
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
T
Q
T
E
L
---
M
D
G
L
N
V
S
V
P
R
--
L
-
D
I
N
Q
A
G
V
V
A
----
L
E
Q
V
R
E
T
----
L
A
----
F
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
S
M
N
D
R
L
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
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I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
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V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
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L
Q
A
T
P
A
T
W
K
M
L
L
D
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S
G
N
A
G
L
T
A
L
C
--
G
G
E
-
A
L
D
T
I
L
A
E
K
L
L
G
K
V
G
C
----
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
--
A
A
R
I
T
---
D
A
K
-
Y
I
D
L
G
E
P
L
A
N
T
Q
L
Y
V
L
-
D
-
E
-
Q
Q
R
L
V
P
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
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Y
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Q
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P
E
L
T
D
A
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L
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L
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A
G
R
L
Y
R
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D
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L
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R
L
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H
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R
L
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Q
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K
I
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G
F
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I
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N
V
L
K
Q
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K
T
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K
L
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A
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V
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-
I
A
G
L
K
K
N
L
Q
I
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L
P
A
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M
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P
S
A
F
I
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L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
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P
I
F
E
Q
-
S
-
N
-
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
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V
K
R
V
G
I
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D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
R
E
N
K
E
-----
I
K
P
S
I
V
I
E
L
R
R
G
T
Y
E
Q
P
-
L
W
L
F
H
P
I
G
G
S
T
F
C
Y
-----
M
E
L
S
R
H
L
N
P
-
N
R
T
L
R
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
52.63
36%
-102
- C1 -
4GR5
3
?
A:
[74-467]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
E
R
A
N
R
L
A
H
R
L
V
G
L
G
V
A
P
G
T
L
V
G
V
H
L
E
R
G
F
D
M
V
V
A
L
L
A
V
L
K
A
G
G
G
Y
T
M
L
D
P
Q
F
P
V
E
R
L
A
L
S
L
E
D
T
G
A
P
L
L
V
T
-
S
R
P
L
S
G
R
L
T
G
---
T
--
T
--
T
L
Y
V
E
D
-------
A
G
N
L
A
T
G
V
G
P
E
D
V
---
A
C
V
M
F
T
S
G
S
T
G
R
P
K
G
V
M
S
P
H
R
A
L
T
G
T
Y
L
G
Q
-
D
Y
A
G
F
G
P
D
E
V
F
L
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C
S
P
V
S
W
D
A
F
G
L
E
L
F
G
A
L
L
F
G
A
R
C
V
L
Q
S
G
Q
-
N
P
D
P
L
E
I
G
E
L
V
A
R
H
G
V
T
M
L
Q
L
S
A
S
---
L
F
N
F
L
V
D
E
V
------
P
E
A
F
E
G
V
R
Y
A
I
T
G
G
E
P
A
S
V
P
H
V
A
K
A
R
R
D
H
--
P
A
L
R
L
G
N
G
Y
G
P
A
E
S
M
G
F
T
T
H
H
A
V
V
A
G
D
---
L
S
G
T
A
L
P
---
I
G
V
P
L
A
G
K
R
A
Y
V
L
-
D
D
D
L
K
P
A
A
N
G
A
L
G
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L
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A
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A
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L
A
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Y
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A
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A
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G
G
E
-
R
M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
51.55
30%
12
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[8-1059]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
C
-
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
E
-
E
I
---------
D
L
T
HLT
G
S
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
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G
F
D
L
T
-
R
D
-
I
P
M
R
A
A
I
F
K
K
A
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E
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F
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W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
----
A
L
----
R
E
Q
K
P
Y
S
-
L
P
P
V
K
P
-
Y
K
D
Y
I
K
W
L
E
K
Q
----
D
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
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Y
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K
E
L
L
F
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P
S
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A
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T
K
A
F
T
E
L
A
K
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--
Q
H
T
T
L
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T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
-------
T
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V
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G
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A
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K
G
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L
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L
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S
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
Q
------
P
K
L
I
D
H
I
I
V
F
E
N
Y
P
L
Q
D
A
K
NEESS---------
E
N
G
F
D
M
V
D
V
------
H
--
V
F
E
K
S
N
Y
D
L
N
L
M
A
S
P
---
G
D
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
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L
L
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N
P
P
A
Q
A
H
E
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P
L
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Y
W
F
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A
V
N
A
N
P
D
A
P
A
L
T
Y
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G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
-
H
Q
E
M
K
E
Q
A
A
E
LPY
T
G
-
T
--
T
L
F
I
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D
Q
T
R
F
E
E
Q
A
S
D
P
A
T
A
I
D
P
N
D
P
---
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
H
V
-
D
Y
M
A
F
S
D
Q
D
T
F
L
S
V
S
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Y
A
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A
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A
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L
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A
A
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L
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A
D
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L
L
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T
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L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
---
L
F
N
L
L
T
D
A
G
------
E
D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
A
L
R
I
M
--
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
V
V
H
D
L
P
---
D
S
I
S
S
L
P
---
I
G
K
P
I
S
N
A
S
V
Y
I
L
-
N
E
Q
S
Q
L
Q
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F
G
A
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G
E
L
C
I
S
G
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G
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V
N
R
A
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L
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F
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F
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--
P
G
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-
T
L
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R
T
G
D
L
A
R
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L
P
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G
T
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Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
----
A
V
V
V
A
D
R
------
H
E
S
G
D
A
S
--
I
N
A
Y
L
V
N
R
T
--
Q
L
S
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
D
Q
L
A
E
E
W
I
G
P
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N
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M
E
E
T
I
A
Q
I
W
S
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L
G
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Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
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I
-
K
K
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G
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L
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L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
51.20
27%
-0
- C1 -
4ZXH
3
?
A:
[12-1047]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
G
N
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-
P
I
E
I
L
E
A
V
M
H
D
Y
P
L
L
R
V
S
M
P
A
N
D
-
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
I
-
F
S
---------
D
A
R
HI----
E
A
S
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L
T
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L
V
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-
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A
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M
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L
L
L
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K
R
F
G
----
L
V
----
A
ES---
D
-
A
V
N
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-
F
V
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-
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--
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-------
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N
P
L
A
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M
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W
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L
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G
M
D
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KELLLPIQTP
A
T
L
V
G
Q
D
L
T
L
G
S
F
----
P
-
V
--
R
Q
Q
E
G
Q
L
D
I
T
L
E
M
G
G
E
Y
-
Q
G
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L
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L
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Y
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D
L
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A
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A
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M
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--
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---
S
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--
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---
A
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----
K
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L
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L
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A
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A
---
T
W
K
M
L
L
D
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-
W
------
S
G
N
A
G
L
T
A
L
C
G
G
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A
L
D
T
I
L
A
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K
L
L
G
K
V
----
G
C
L
W
N
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Y
G
P
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T
T
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W
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A
A
R
I
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A
-------
K
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I
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---
L
G
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L
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T
Q
L
Y
V
L
-
D
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L
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L
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N
A
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-
R
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----
A
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------
T
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--
L
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A
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---
L
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L
K
K
N
L
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Y
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V
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R
L
G
E
I
I
R
E
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
50.89
25%
4
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[2-1041]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
V
A
A
Q
P
G
I
W
M
A
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K
L
S
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S
A
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-
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L
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N
-
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L
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I
---------
D
L
R
TNID--
P
H
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----
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P
-----
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-------
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--------------
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V
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----
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----
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A
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-
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L
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---
V
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-
N
L
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L
C
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N
A
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-
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L
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L
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---
A
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T
T
H
F
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---
M
L
A
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-
T
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A
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A
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Q
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---
G
A
P
L
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L
Y
G
P
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A
A
V
D
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A
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A
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---
I
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Y
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L
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D
A
M
M
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A
L
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----
A
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A
C
V
INQAAA
T
G
G
D
A
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Q
--
L
V
G
Y
L
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L
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L
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T
S
A
L
Q
A
Q
L
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L
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P
H
M
V
P
V
V
L
L
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L
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Q
L
P
L
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A
N
G
K
L
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K
A
L
P
L
P
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L
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-
A
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A
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A
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A
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A
A
A
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L
L
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C
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A
D
A
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A
L
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-
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A
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T
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A
K
L
A
T
I
I
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
50.71
38%
-3
- C1 -
5ES8
1
LGRA_BREPA
B:
[198-760]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
-
I
D
K
T
F
H
Q
L
F
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Q
V
E
M
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A
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I
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A
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A
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G
A
Y
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D
Y
P
G
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R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
-------
A
L
H
E
E
K
A
N
G
AC
D
-
I
I
D
V
H
D
P
D
S
----
Y
S
E
N
T
N
N
----
L
P
HVNR
P
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
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M
I
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H
H
N
L
V
N
F
C
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Y
R
P
Y
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A
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A
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Y
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S
F
S
F
D
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A
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I
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L
L
A
G
A
A
L
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V
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K
Y
D
L
D
A
L
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D
----
Y
C
N
Q
E
G
I
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Y
L
P
T
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A
A
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M
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V
L
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--
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--
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N
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----
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--
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---
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L
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A
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L
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L
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L
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L
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L
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Y
D
Q
L
F
T
H
P
T
I
R
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
49.34
27%
-52
- C1 -
4DG8
3
?
A:
[27-515]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
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E
A
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R
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R
F
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S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
T
T
---
P
T
P
A
N
G
L
P
------
C
V
P
V
R
H
L
P
A
A
P
--
A
S
V
A
R
P
C
----
F
A
----
A
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
L
C
L
G
Q
-
S
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
-
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
T
L
V
D
L
D
-
P
D
C
L
G
G
L
R
Q
L
L
T
G
G
D
-
I
L
S
V
P
H
V
R
--
R
A
L
L
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
--
C
H
V
V
T
D
D
D
L
E
E
D
D
I
P
I
G
K
A
I
A
G
T
A
V
L
L
L
-
D
-
E
H
G
Q
E
I
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
R
G
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
R
E
R
N
G
V
-
K
Q
L
L
C
A
W
T
G
K
----
A
D
A
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
L
R
R
L
E
E
P
-
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
49.17
36%
-64
- C1 -
4GR5
3
?
D:
[72-467]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
E
R
A
N
R
L
A
H
R
L
V
G
L
G
V
A
P
G
T
L
V
G
V
H
L
E
R
G
F
D
M
V
V
A
L
L
A
V
L
K
A
G
G
G
Y
T
M
L
D
P
Q
F
P
V
E
R
L
A
L
S
L
E
D
T
G
A
P
L
L
V
T
-
S
R
P
L
S
--
G
R
L
---
T
G
T
T
--
T
L
Y
V
E
D
-------
A
G
N
L
A
T
G
V
G
P
E
D
V
---
A
C
V
M
F
T
S
G
S
T
G
R
P
K
G
V
M
S
P
H
R
A
L
T
G
T
Y
L
G
Q
D
Y
A
-
G
F
G
P
D
E
V
F
L
Q
C
S
P
V
S
W
D
A
F
G
L
E
L
F
G
A
L
L
F
G
A
R
C
V
L
Q
S
G
Q
N
P
-
D
P
L
E
I
G
E
L
V
A
R
H
G
V
T
M
L
Q
L
S
A
S
---
L
F
N
F
L
V
--
D
-
E
---
V
P
E
A
F
E
G
V
R
Y
A
I
T
G
G
E
P
A
S
V
P
H
V
A
K
A
R
R
D
H
--
P
A
L
R
L
G
N
G
Y
G
P
A
E
S
M
G
F
T
T
H
H
A
V
V
A
G
D
---
L
S
G
T
A
L
P
---
I
G
V
P
L
A
G
K
R
A
Y
V
L
-
D
D
D
L
K
P
A
A
N
G
A
L
G
E
L
Y
V
A
G
A
G
L
A
H
G
Y
V
S
R
P
A
L
T
A
E
R
F
V
A
D
P
F
A
GP
G
G
E
-
R
M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
48.97
36%
-62
- C1 -
4GR5
3
?
A:
[72-467]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
E
R
A
N
R
L
A
H
R
L
V
G
L
G
V
A
P
G
T
L
V
G
V
H
L
E
R
G
F
D
M
V
V
A
L
L
A
V
L
K
A
G
G
G
Y
T
M
L
D
P
Q
F
P
V
E
R
L
A
L
S
L
E
D
T
G
A
P
L
L
V
T
-
S
R
P
L
S
--
G
R
L
---
T
G
T
T
--
T
L
Y
V
E
D
-------
A
G
N
L
A
T
G
V
G
P
E
D
V
---
A
C
V
M
F
T
S
G
S
T
G
R
P
K
G
V
M
S
P
H
R
A
L
T
G
T
Y
L
G
Q
D
Y
A
-
G
F
G
P
D
E
V
F
L
Q
C
S
P
V
S
W
D
A
F
G
L
E
L
F
G
A
L
L
F
G
A
R
C
V
L
Q
S
G
Q
N
P
-
D
P
L
E
I
G
E
L
V
A
R
H
G
V
T
M
L
Q
L
S
A
S
---
L
F
N
F
L
V
--
D
-
E
---
V
P
E
A
F
E
G
V
R
Y
A
I
T
G
G
E
P
A
S
V
P
H
V
A
K
A
R
R
D
H
--
P
A
L
R
L
G
N
G
Y
G
P
A
E
S
M
G
F
T
T
H
H
A
V
V
A
G
D
---
L
S
G
T
A
L
P
---
I
G
V
P
L
A
G
K
R
A
Y
V
L
-
D
D
D
L
K
P
A
A
N
G
A
L
G
E
L
Y
V
A
G
A
G
L
A
H
G
Y
V
S
R
P
A
L
T
A
E
R
F
V
A
D
P
F
A
GP
G
G
E
-
R
M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------