@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu19220: (2016-07-01 )
MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGGGKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLNGLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEILFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKDRFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERFLNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLFSPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACGQCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLSTYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEALKAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKGVGEQKRAKYGRLFLQEIQAYARMTD
Atome Classification :
(22 SA)
...-......10........20........30........40........50........60........70........80........90.....---.----..100..--.--....110.......-120-.-..-----....130......---..140.......150.......160.......170.......180.......190.......200.......210.....----.--..220--...-.--.-..-230.........240.......250.......260.......270......-.280.......290.......300.......310.......320.......330.......340.....--...350.-......360.......-370........380...-.--.--..390----..-----......400-........410...---..------..420.........430.......440.......450....-...460.....--..470.......------480.---........490.....-..----500----------.......--510.......520----.......530.......540.......550.......560.......570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
H
-
R
A
Q
S
L
L
A
H
Y
F
G
Y
E
K
FRSG
Q
D
E
A
I
R
L
V
T
EARQN
T
A
C
I
M
PTGGG
K
S
I
C
Y
QI
P
A
L
MFEG
T
T
I
V
I
S
P
L
I
S
L
M
K
D
Q
V
D
A
L
E
E
AGI
N
A
A
Y
INSTQS
N
Q
E
---
I
----
Y
E
R
L
N
G
L
--K--EG
A
Y
K
L
F
Y
I
T
P
E
RL-
T
S
I
-
E
-
F
I
-----
R
I
L
QGI-DV
P
L
V
A
---ID
E
A
H
C
I
S
Q
WGHDFRPSY
R
N
I
E
I
L
F
R
E
LHDK
P
V
I
M
A
L
TATATP
E
V
H
D
D
I
C
K
Q
LHIQKEN
T
V
Y
TGFSRE
N
L
T
F
K
V
-
V
KGE
N
----
K
--
D
R
F
I
D
--
E
Y
V
-Q--N-NR-H--EA
G
I
V
Y
T
A
T
R
K
E
A
D
R
I
Y
E
R
L
K
RNQVRAGRYHGG
L
A
D
D
V
R
K
E
Q
Q
E
R
F
LN-DE
L
Q
V
M
V
ATSAFGMGIDKS
N
I
R
F
V
L
HAQI
P
K
D
M
E
S
Y
Y
Q
E
AGRAGRDGLASE
C
V
L
L
FS
P
Q
D
I
M
-
V
Q
R
F
L
I--EQ
S
E
H
E
E
-
K
Q
K
Q
D
L
K
K
L
R
Q
M
V
D
YC-
H
T
-
E
D
C
L
Q
R
F
I
L
M
Y
FGE-K--E--
P
D
AC-----GQ-----CGNCTDT
R
--
A
A
H
D
V
T
R
E
A
Q
M
V
L
S
---
C
I
------
I
R
M
--
K
E
RF
G
K
T
M
V
A
Q
V
L
AGSKN
K
K
V
L
E
NGFS
D
L
S
T
Y
GILK-HQSV
G
E
I
S
D
F
I
--
E
F
L
ISD
D
F
I
RMS------D--G---T
F
P
T
L
F
VSSKGRNV
L
K
-
G
E
----
L
S
V
----------
A
R
K
E
A
L
K
--
A
AAITE
N
D
E
L
F
E
R
----
L
R
M
V
R
K
E
I
A
A
EQGVP
P
F
V
V
FSD
Q
T
L
K
E
MSGKQPVNDD
E
L
L
S
IKGV
G
E
Q
K
R
A
K
Y
G
R
L
F
L
Q
E
I
Q
A
Y
ARMTD
2
PsiBlast_PDB
80.80
41%
-132
- C4 -
4TMU
1
?
A:
[33-534]
-----
A
K
Q
V
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
A
T
I
I
D
A
V
L
E
G
R
-
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
V
K
T
G
L
T
I
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
L
A
N
G
V
A
A
A
C
L
N
S
T
Q
S
R
E
E
---
Q
----
Q
A
V
L
A
G
C
--
R
--
T
G
Q
V
R
L
L
Y
I
A
P
E
R
L
-
M
M
D
-
N
-
F
I
-----
D
T
L
G
Y
W
-
D
L
A
M
V
A
---
V
D
E
A
H
C
I
S
Q
W
G
H
D
F
R
P
E
Y
A
A
L
G
Q
L
R
A
R
F
P
A
V
P
-
F
M
A
L
T
A
T
A
D
D
T
T
R
R
D
I
V
R
L
L
G
L
D
D
P
L
I
E
I
S
S
F
D
R
P
N
I
R
Y
M
L
-
M
E
K
F
K
----
P
--
L
D
Q
L
M
--
R
Y
V
-
Q
--
E
-
Q
R
-
G
--
K
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
R
G
I
S
A
A
A
Y
H
A
G
L
E
H
E
V
R
A
S
V
Q
E
K
F
Q
R
-
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
M
A
-
W
L
R
R
C
L
--
E
E
K
A
P
G
P
-
L
Q
D
I
E
R
H
K
L
N
A
M
G
A
F
A
-
E
A
-
Q
T
C
R
R
L
V
L
L
N
Y
F
G
E
-
G
--
R
--
Q
A
P
C
-----
G
N
-----
C
D
I
C
L
D
P
P
--
R
R
Y
D
G
L
V
D
A
Q
K
A
L
S
---
A
I
------
A
R
V
--
E
Q
R
F
G
M
G
Y
V
V
E
V
L
R
G
A
N
N
Q
R
I
R
E
L
G
H
D
K
L
K
V
Y
G
I
G
R
-
D
Q
S
Q
E
H
W
V
S
V
I
--
R
Q
L
I
H
L
G
V
V
T
Q
N
------
I
--
A
---
Q
H
S
A
L
Q
L
T
E
A
A
R
P
F
L
R
-
G
E
A
P
L
M
L
A
V
----------
P
R
---------------------------------------------------------------------------------------------
45
HHSearch
78.38
39%
-121
- C4 -
1OYW
2
RECQ_ECOLI
A:
[10-513]
-
E
S
-
G
A
K
Q
V
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
-
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
G
V
A
A
A
C
L
N
S
T
Q
T
R
E
Q
---
Q
----
L
E
V
M
T
G
C
--
R
--
T
G
Q
I
R
L
L
Y
I
A
P
E
R
L
-
M
L
D
-
N
-
F
L
-----
E
H
L
A
H
W
-
N
P
V
L
L
A
---
V
D
E
A
H
C
I
S
Q
W
G
H
D
F
R
P
E
Y
A
A
L
G
Q
L
R
Q
R
F
P
-
T
L
P
F
M
A
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
L
N
D
P
L
I
Q
I
S
S
F
D
R
P
N
I
R
Y
M
L
-
M
E
K
F
K
----
P
--
L
D
Q
L
M
--
R
Y
V
-
Q
--
E
-
Q
R
-
G
--
K
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
K
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
-
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
M
A
-
W
L
R
R
C
L
--
E
E
K
P
Q
G
Q
-
L
Q
D
I
E
R
H
K
L
N
A
M
G
A
F
A
-
E
A
-
Q
T
C
R
R
L
V
L
L
N
Y
F
G
E
-
G
--
R
--
Q
E
P
C
-----
G
N
-----
C
D
I
C
L
D
P
P
--
K
Q
Y
D
G
S
T
D
A
Q
I
A
L
S
---
T
I
------
G
R
V
--
N
Q
R
F
G
M
G
Y
V
V
E
V
I
R
G
A
N
N
Q
R
I
R
D
Y
G
H
D
K
L
K
V
Y
G
M
G
R
-
D
K
S
H
E
H
W
V
S
V
I
--
R
Q
L
I
H
L
G
L
V
T
Q
N
------
I
--
A
---
Q
H
S
A
L
Q
L
T
E
A
A
R
P
V
L
R
-
G
E
----
S
S
L
----------
Q
L
A
V
P
------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.99
39%
-120
- C4 -
1OYW
2
RECQ_ECOLI
A:
[13-516]
-----
A
K
Q
V
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
R
-
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
G
V
A
A
A
C
L
N
S
T
Q
T
R
E
Q
---
Q
----
L
E
V
M
T
G
C
--
R
--
T
G
Q
I
R
L
L
Y
I
A
P
E
R
L
-
M
L
D
-
N
-
F
L
-----
E
H
L
A
H
W
-
N
P
V
L
L
A
---
V
D
E
A
H
C
I
S
Q
W
G
H
D
F
R
P
E
Y
A
A
L
G
Q
L
R
Q
R
F
P
T
L
P
-
F
M
A
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
L
N
D
P
L
I
Q
I
S
S
F
D
R
P
N
I
R
Y
M
L
-
M
E
K
F
K
----
P
--
L
D
Q
L
M
--
R
Y
V
-
Q
--
E
-
Q
R
-
G
--
K
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
K
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
-
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
M
A
-
W
L
R
R
C
L
--
E
E
K
P
Q
G
Q
-
L
Q
D
I
E
R
H
K
L
N
A
M
G
A
F
A
-
E
A
-
Q
T
C
R
R
L
V
L
L
N
Y
F
G
E
-
G
--
R
--
Q
E
P
C
-----
G
N
-----
C
D
I
C
L
D
P
P
--
K
Q
Y
D
G
S
T
D
A
Q
I
A
L
S
---
T
I
------
G
R
V
--
N
Q
R
F
G
M
G
Y
V
V
E
V
I
R
G
A
N
N
Q
R
I
R
D
Y
G
H
D
K
L
K
V
Y
G
M
G
R
-
D
K
S
H
E
H
W
V
S
V
I
--
R
Q
L
I
H
L
G
L
V
T
Q
N
------
I
--
A
---
Q
H
S
A
L
Q
L
T
E
A
A
R
P
V
L
R
-
G
E
S
S
L
Q
L
A
V
----------
P
R
I
V
-------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.77
40%
-119
- C4 -
1OYY
3
RECQ_ECOLI
A:
[13-516]
-----
A
K
Q
V
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
R
-
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
G
V
A
A
A
C
L
N
S
T
Q
T
R
E
Q
---
Q
----
L
E
V
M
T
G
C
--
R
--
T
G
Q
I
R
L
L
Y
I
A
P
E
R
L
-
M
L
D
-
N
-
F
L
-----
E
H
L
A
H
W
-
N
P
V
L
L
A
---
V
D
E
A
H
C
I
S
Q
W
G
H
D
F
R
P
E
Y
A
A
L
G
Q
L
R
Q
R
F
P
T
L
P
-
F
M
A
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
L
N
D
P
L
I
Q
I
S
S
F
D
R
P
N
I
R
Y
M
L
-
M
E
K
F
K
----
P
--
L
D
Q
L
M
--
R
Y
V
-
Q
--
E
-
Q
R
-
G
--
K
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
K
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
-
D
D
L
Q
I
V
V
A
T
V
A
----
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
M
A
-
W
L
R
R
C
L
--
E
E
K
P
Q
G
Q
-
L
Q
D
I
E
R
H
K
L
N
A
M
G
A
F
A
-
E
A
-
Q
T
C
R
R
L
V
L
L
N
Y
F
G
E
-
G
--
R
--
Q
E
P
C
-----
G
N
-----
C
D
I
C
L
D
P
P
--
K
Q
Y
D
G
S
T
D
A
Q
I
A
L
S
---
T
I
------
G
R
V
--
N
Q
R
F
G
M
G
Y
V
V
E
V
I
R
G
A
N
N
Q
R
I
R
D
Y
G
H
D
K
L
K
V
Y
G
M
G
R
-
D
K
S
H
E
H
W
V
S
V
I
--
R
Q
L
I
H
L
G
L
V
T
Q
N
------
I
--
A
---
Q
H
S
A
L
Q
L
T
E
A
A
R
P
V
L
R
-
G
E
S
S
L
Q
L
A
V
----------
P
R
I
V
-------------------------------------------------------------------------------------------
46
HHSearch
73.48
40%
-68
- C4 -
4Q48
1
?
A:
[9-511]
-
H
D
-
R
A
L
H
L
L
Q
T
I
W
G
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
-
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
L
L
R
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
N
G
V
R
A
A
F
L
N
S
T
L
L
P
H
E
---
A
----
R
E
V
E
D
A
L
--
L
--
R
G
D
L
D
L
L
Y
V
A
P
E
R
L
-
L
M
P
-
R
-
T
L
-----
D
L
L
E
R
A
-
P
V
A
L
F
A
---
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
A
E
R
F
P
-
E
L
P
R
V
A
L
T
A
T
A
D
E
R
T
R
A
D
I
K
S
V
L
R
L
E
D
A
P
Q
F
V
S
S
F
D
R
P
N
I
Q
Y
R
V
-
G
L
K
D
S
----
P
--
K
T
Q
L
L
--
H
F
I
-
R
--
E
E
H
P
-
G
--
D
A
G
I
V
Y
C
L
S
R
K
S
V
E
E
T
A
K
W
L
Q
A
Q
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
-
E
E
G
V
I
V
C
A
T
V
A
-----
D
K
P
N
V
R
F
V
A
H
L
D
L
P
K
S
M
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
S
T
A
W
M
V
Y
G
L
S
D
V
V
-
N
V
R
R
M
L
--
A
Q
S
D
A
P
E
E
V
K
R
V
E
A
S
K
L
D
A
L
L
T
Y
C
-
E
A
-
A
T
C
R
R
Q
V
L
L
H
Y
F
G
E
-
E
--
L
--
S
E
P
C
-----
G
N
-----
C
D
V
C
L
N
P
P
--
R
V
R
D
L
T
R
E
A
Q
M
A
L
S
---
A
T
------
I
R
T
--
G
N
R
F
G
A
A
H
L
T
D
V
L
L
G
R
E
T
D
K
V
L
A
Q
G
H
H
Q
L
P
T
F
G
V
G
K
-
E
H
D
E
K
L
W
R
S
V
L
--
R
Q
L
V
S
L
G
Y
L
S
A
D
------
D
-------
H
F
G
L
R
A
T
G
K
S
R
G
I
L
K
-
E
G
----
Q
K
L
----------
L
L
R
E
-------------------------------------------------------------------------------------------
44
HHSearch
72.27
35%
14
- C4 -
4O3M
12
BLM_HUMAN
A:
[14-650]
--
K
-
E
M
M
K
I
F
H
K
K
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
-
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
C
V
S
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
D
I
P
A
T
Y
L
T
G
D
K
T
D
S
E
---
A
----
T
N
I
Y
L
Q
L
--
S
KK
D
P
I
I
K
L
L
Y
V
T
P
E
K
I
-
C
A
S
N
R
-
L
I
S
T
L
E
-
N
L
Y
E
R
K
-
L
L
A
R
F
V
---
I
D
E
A
H
---------
R
Q
D
Y
K
R
M
N
M
L
R
Q
K
F
P
-
S
V
P
V
M
A
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
Y
Y
V
-
L
P
K
K
P
----
K
K
V
A
F
D
C
L
--
E
W
I
-
R
--
K
H
H
P
-
Y
--
D
S
G
I
I
Y
C
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
V
T
-
R
L
K
R
L
I
--
M
M
E
K
D
-
H
-
T
R
E
T
H
F
N
N
L
Y
S
M
V
H
Y
C
-
E
N
I
T
E
C
R
R
I
Q
L
L
A
Y
F
G
E
-
N
--
G
FN
P
D
F
C
K
K
H
PD
V
S
-----
C
D
N
C
C
K
--Y-
K
T
R
D
V
T
D
D
V
K
S
I
V
R
---
F
V
------
Q
E
H
SP
S
G
R
F
T
M
N
M
L
V
D
I
F
L
G
S
K
S
A
K
I
Q
------
S
G
I
F
G
K
G
S
-
A
Y
S
R
H
N
A
E
R
L
F
--
K
K
L
I
L
D
K
I
L
D
E
D
L
Y
I
N
AN
D
--
Q
---
A
I
A
Y
V
M
L
G
N
K
A
Q
T
V
L
N
-
G
N
----
L
K
V
----------
D
F
M
E
T
E
N
KV
S
Q
R
E
E
M
V
K
K
C
L
G
E
----
L
T
E
V
C
K
S
L
G
K
V
F
G
V
H
Y
F
N
I
F
N
T
V
T
L
K
K
L
A
E
S
L
S
S
D
P
E
V
L
L
Q
I
D
G
V
T
E
D
K
L
E
K
Y
G
A
E
V
I
S
V
L
Q
K
Y
S
E
W
T
-
22
PsiBlast_CBE
70.15
40%
-20
- C4 -
4Q47
3
?
B:
[8-514]
-
L
H
D
R
A
L
H
L
L
Q
T
I
W
G
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
-
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
L
L
R
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
N
G
V
R
A
A
F
L
N
S
T
L
L
P
H
E
---
A
----
R
E
V
E
D
A
L
--
L
--
R
G
D
L
D
L
L
Y
V
A
P
E
R
L
-
L
M
P
-
R
-
T
L
-----
D
L
L
E
R
A
-
P
V
A
L
F
A
---
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
A
E
R
F
P
E
L
P
R
V
-
A
L
T
A
T
A
D
E
R
T
R
A
D
I
K
S
V
L
R
L
E
D
A
P
Q
F
V
S
S
F
D
R
P
N
I
Q
Y
R
V
G
L
K
D
S
P
----
K
--
T
Q
L
L
H
--
F
I
R
-
E
--
E
-
H
P
-
G
--
D
A
G
I
V
Y
C
L
S
R
K
S
V
E
E
T
A
K
W
L
Q
A
Q
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
-
E
E
G
V
I
V
C
A
T
V
A
-----
D
K
P
N
V
R
F
V
A
H
L
D
L
P
K
S
M
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
S
T
A
W
M
V
Y
G
L
S
D
V
V
N
V
R
R
M
L
A
--
Q
S
D
A
P
E
E
-
V
K
R
V
E
A
S
K
L
D
A
L
L
T
Y
C
-
E
A
-
A
T
C
R
R
Q
V
L
L
H
Y
F
G
E
-
E
--
L
--
S
E
P
C
-----
G
N
-----
C
D
V
C
L
N
P
P
--
R
V
R
D
L
T
R
E
A
Q
M
A
L
S
---
A
T
------
I
R
T
--
G
N
R
F
G
A
A
H
L
T
D
V
L
L
G
R
E
T
D
K
V
L
A
Q
G
H
H
Q
L
P
T
F
G
V
G
K
-
E
H
D
E
K
L
W
R
S
V
L
--
R
Q
L
V
S
L
G
Y
L
S
A
D
------
D
--
H
---
F
--
G
L
R
A
T
G
K
S
R
G
I
L
K
E
G
Q
----
K
L
L
----------
L
R
E
D
T
L
-----------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.73
34%
22
- C4 -
4CGZ
4
BLM_HUMAN
A:
[30-656]
-------------
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
-
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
C
V
S
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
D
I
P
A
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
----
Y
L
Q
L
S
K
---
K
--
D
P
I
I
K
L
L
Y
V
T
P
E
K
I
C
A
S
N
-
R
-
L
I
-----
S
T
L
E
N
L
Y
E
R
K
L
L
A
R
F
V
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
Q
D
Y
K
R
M
N
M
L
R
Q
K
F
P
S
V
P
V
-
M
A
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
Y
Y
V
-
L
P
K
K
P
----
K
--
K
V
A
F
D
C
L
E
W
I
-
R
--
K
-
H
H
P
Y
--
D
S
G
I
I
Y
C
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
V
T
-
R
L
K
R
L
I
M
M
E
K
D
G
N
H
H
-
T
R
E
T
H
F
N
N
L
Y
S
M
V
H
Y
C
E
N
I
-
T
E
C
R
R
I
Q
L
L
A
Y
F
G
E
-
N
GF
N
--
P
D
F
C
-----
K
K
H
PDVS
C
D
N
C
C
K
T
K
D
Y
K
T
R
D
V
T
D
D
V
K
S
I
V
R
---
F
V
Q
E
H
S
SS------
G
R
F
T
M
N
M
L
V
D
I
F
L
G
S
K
S
A
K
I
Q
S
G
I
F
G
K
G
S
A
Y
S
--
R
-
H
N
A
E
R
L
F
K
K
L
I
L
D
K
I
L
D
E
D
L
Y
I
N
A
N
------
D
--
Q
---
A
I
A
Y
V
M
L
G
N
K
A
Q
T
V
L
N
-
G
N
----
L
K
V
D
F
M
E
T
E---------------
K
V
S
Q
R
E
E
M
V
K
K
C
L
G
E
L
T
E
V
C
K
S
L
G
K
V
F
G
V
H
Y
F
N
I
F
N
T
V
T
L
K
K
L
A
E
S
L
S
S
D
P
E
V
L
L
Q
I
D
G
V
T
E
D
K
L
E
K
Y
G
A
E
V
I
S
V
L
Q
K
Y
S
E
W
T
-
7
PsiBlast_PDB
69.58
34%
20
- C4 -
4O3M
11
BLM_HUMAN
A:
[24-650]
-------------
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
-
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
C
V
S
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
D
I
P
A
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
----
Y
L
Q
L
S
K
---
K
--
D
P
I
I
K
L
L
Y
V
T
P
E
K
I
C
A
S
N
-
R
-
L
I
-----
S
T
L
E
N
L
Y
E
R
K
L
L
A
RFV
I
D
E
A
H
---------
R
Q
D
Y
K
R
M
N
M
L
R
Q
K
F
P
S
V
P
V
-
M
A
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
Y
Y
V
-
L
P
K
K
P
----
K
--
K
V
A
F
D
C
L
E
W
I
R
K
--
H
-
H
P
-
Y
--
D
S
G
I
I
Y
C
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
V
T
-
R
L
K
R
L
I
M
M
E
K
D
---
H
-
T
R
E
T
H
F
N
N
L
Y
S
M
V
H
Y
C
E
N
I
-
T
E
C
R
R
I
Q
L
L
A
Y
F
G
E
-
N
GF
N
--
P
D
F
C
-----
K
K
H
PDVS
C
D
N
C
C
K
--Y-
K
T
R
D
V
T
D
D
V
K
S
I
V
R
---
F
V
Q
E
H
S----
P
--
S
G
R
F
T
M
N
M
L
V
D
I
F
L
G
S
K
S
A
K
I
Q
S
G
I
F
G
K
G
S
A
Y
S
--
R
-
H
N
A
E
R
L
F
K
K
L
I
L
D
K
I
L
D
E
D
L
Y
I
N
A
N
------
D
--
Q
---
A
I
A
Y
V
M
L
G
N
K
A
Q
T
V
L
N
-
G
N
----
L
K
V
D
F
M
E
T
E
N--------------
K
V
S
Q
R
E
E
M
V
K
K
C
L
G
E
L
T
E
V
C
K
S
L
G
K
V
F
G
V
H
Y
F
N
I
F
N
T
V
T
L
K
K
L
A
E
S
L
S
S
D
P
E
V
L
L
Q
I
D
G
V
T
E
D
K
L
E
K
Y
G
A
E
V
I
S
V
L
Q
K
Y
S
E
W
T
-
3
PsiBlast_PDB
69.25
40%
-17
- C4 -
4Q47
2
?
A:
[8-514]
-
L
H
D
R
A
L
H
L
L
Q
T
I
W
G
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
-
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
L
L
R
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
N
G
V
R
A
A
F
L
N
S
T
L
L
P
H
E
---
A
----
R
E
V
E
D
A
L
--
L
--
R
G
D
L
D
L
L
Y
V
A
P
E
R
L
-
L
M
P
-
R
-
T
L
-----
D
L
L
E
R
A
-
P
V
A
L
F
A
---
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
A
E
R
F
P
E
L
P
R
V
-
A
L
T
A
T
A
D
E
R
T
R
A
D
I
K
S
V
L
R
L
E
D
A
P
Q
F
V
S
S
F
D
R
P
N
I
Q
Y
R
V
G
L
K
D
S
P
----
K
--
T
Q
L
L
H
--
F
I
R
-
E
--
E
-
H
P
-
G
--
D
A
G
I
V
Y
C
L
S
R
K
S
V
E
E
T
A
K
W
L
Q
A
Q
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
-
E
E
G
V
I
V
C
A
T
V
A
----
I
D
K
P
N
V
R
F
V
A
H
L
D
L
P
K
S
M
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
S
T
A
W
M
V
Y
G
L
S
D
V
V
N
V
R
R
M
L
A
--
Q
S
D
A
P
E
E
-
V
K
R
V
E
A
S
K
L
D
A
L
L
T
Y
C
-
E
A
-
A
T
C
R
R
Q
V
L
L
H
Y
F
G
E
-
E
--
L
--
S
E
P
C
-----
G
N
-----
C
D
V
C
L
N
P
P
--
R
V
R
D
L
T
R
E
A
Q
M
A
L
S
---
A
T
------
I
R
T
--
G
N
R
F
G
A
A
H
L
T
D
V
L
L
G
R
E
T
D
K
V
L
A
Q
G
H
H
Q
L
P
T
F
G
V
G
K
-
E
H
D
E
K
L
W
R
S
V
L
--
R
Q
L
V
S
L
G
Y
L
S
A
D
------
D
--
H
---
F
--
G
L
R
A
T
G
K
S
R
G
I
L
K
E
G
Q
----
K
L
L
----------
L
R
E
D
T
L
-----------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.22
34%
22
- C4 -
4CDG
2
BLM_HUMAN
A:
[30-656]
-------------
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
-
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
C
V
S
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
D
I
P
A
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
----
Y
L
Q
L
S
K
---
K
--
D
P
I
I
K
L
L
Y
V
T
P
E
K
I
C
A
S
N
-
R
-
L
I
-----
S
T
L
E
N
L
Y
E
R
K
L
L
A
R
F
V
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
Q
D
Y
K
R
M
N
M
L
R
Q
K
F
P
S
V
P
V
-
M
A
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
Y
Y
V
-
L
P
K
K
P
----
K
--
K
V
A
F
D
C
L
E
W
I
R
K
--
H
-
H
P
-
Y
--
D
S
G
I
I
Y
C
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
V
T
-
R
L
K
R
------------
T
R
E
T
H
F
N
N
L
Y
S
M
V
H
Y
C
E
N
I
-
T
E
C
R
R
I
Q
L
L
A
Y
F
G
E
-
N
GF
N
--
P
D
F
C
-----
K
K
H
PDVS
C
D
N
C
C
K
T
K
D
Y
K
T
R
D
V
T
D
D
V
K
S
I
V
R
---
F
V
Q
E
H----------
R
F
T
M
N
M
L
V
D
I
F
L
G
S
K
S
A
K
I
Q
S
G
I
F
G
K
G
S
A
Y
S
--
R
-
H
N
A
E
R
L
F
K
K
L
I
L
D
K
I
L
D
E
D
L
Y
I
N
A
N
------
D
--
Q
---
A
I
A
Y
V
M
L
G
N
K
A
Q
T
V
L
N
-
G
N
----
L
K
V
D
F
M
E
T
E
N
SS
S
V
K
K
Q
K
A
L
--
V
A
K
V
S
Q
R
E
E
M
V
K
K
C
L
G
E
L
T
E
V
C
K
S
L
G
K
V
F
G
V
H
Y
F
N
I
F
N
T
V
T
L
K
K
L
A
E
S
L
S
S
D
P
E
V
L
L
Q
I
D
G
V
T
E
D
K
L
E
K
Y
G
A
E
V
I
S
V
L
Q
K
Y
S
E
W
T
-
23
PsiBlast_CBE
68.75
34%
25
- C4 -
4CDG
2
BLM_HUMAN
B:
[30-656]
-------------
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
-
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
C
V
S
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
D
I
P
A
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
----
Y
L
Q
L
S
K
---
K
--
D
P
I
I
K
L
L
Y
V
T
P
E
K
I
C
A
S
N
-
R
-
L
I
-----
S
T
L
E
N
L
Y
E
R
K
L
L
A
R
F
V
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
Q
D
Y
K
R
M
N
M
L
R
Q
K
F
P
S
V
P
V
-
M
A
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
Q
V
F
S
M
S
F
N
R
H
N
L
K
Y
Y
V
-
L
P
K
K
P
----
K
--
K
V
A
F
D
C
L
E
W
I
R
K
--
H
-
H
P
-
Y
--
D
S
G
I
I
Y
C
L
S
R
R
E
C
D
T
M
A
D
T
L
Q
R
D
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
V
T
-
R
L
K
--------------
R
E
T
H
F
N
N
L
Y
S
M
V
H
Y
C
E
N
I
-
T
E
C
R
R
I
Q
L
L
A
Y
F
G
E
-
N
GF
N
--
P
D
F
C
-----
K
K
H
PDVS
C
D
N
C
C
K
T
K
D
Y
K
T
R
D
V
T
D
D
V
K
S
I
V
R
---
F
V
Q
E
H
S--------
G
R
F
T
M
N
M
L
V
D
I
F
L
G
S
K
S
A
K
I
Q
S
G
I
F
G
K
G
S
A
Y
S
--
R
-
H
N
A
E
R
L
F
K
K
L
I
L
D
K
I
L
D
E
D
L
Y
I
N
-----------
Q
---
A
I
A
Y
V
M
L
G
N
K
A
Q
T
V
L
N
-
G
N
----
L
K
V
D
F
M
E
T
E
N
SS
S
V
K
K
Q
K
A
------
V
S
Q
R
E
E
M
V
K
K
C
L
G
E
L
T
E
V
C
K
S
L
G
K
V
F
G
V
H
Y
F
N
I
F
N
T
V
T
L
K
K
L
A
E
S
L
S
S
D
P
E
V
L
L
Q
I
D
G
V
T
E
D
K
L
E
K
Y
G
A
E
V
I
S
V
L
Q
K
Y
S
E
W
T
-
4
PsiBlast_PDB
68.32
40%
-5
- C4 -
4Q48
1
?
A:
[8-512]
-
L
H
D
R
A
L
H
L
L
Q
T
I
W
G
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
-
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
L
L
R
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
N
G
V
R
A
A
F
L
N
S
T
L
L
P
H
E
---
A
----
R
E
V
E
D
A
L
--
L
--
R
G
D
L
D
L
L
Y
V
A
P
E
R
L
-
L
M
P
-
R
-
T
L
-----
D
L
L
E
R
A
-
P
V
A
L
F
A
---
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
A
E
R
F
P
E
L
P
R
V
-
A
L
T
A
T
A
D
E
R
T
R
A
D
I
K
S
V
L
R
L
E
D
A
P
Q
F
V
S
S
F
D
R
P
N
I
Q
Y
R
V
G
L
K
D
S
P
----
K
--
T
Q
L
L
H
--
F
I
R
-
E
--
E
-
H
P
-
G
--
D
A
G
I
V
Y
C
L
S
R
K
S
V
E
E
T
A
K
W
L
Q
A
Q
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
-
E
E
G
V
I
V
C
A
T
V
A
-----
D
K
P
N
V
R
F
V
A
H
L
D
L
P
K
S
M
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
S
T
A
W
M
V
Y
G
L
S
D
V
V
N
V
R
R
M
L
A
--
Q
S
D
A
P
E
E
-
V
K
R
V
E
A
S
K
L
D
A
L
L
T
Y
C
-
E
A
-
A
T
C
R
R
Q
V
L
L
H
Y
F
G
E
-
E
--
L
--
S
E
P
C
-----
G
N
-----
C
D
V
C
L
N
P
P
--
R
V
R
D
L
T
R
E
A
Q
M
A
L
S
---
A
T
------
I
R
T
--
G
N
R
F
G
A
A
H
L
T
D
V
L
L
G
R
E
T
D
K
V
L
A
Q
G
H
H
Q
L
P
T
F
G
V
G
K
-
E
H
D
E
K
L
W
R
S
V
L
--
R
Q
L
V
S
L
G
Y
L
S
A
D
------
D
--
H
---
F
--
G
L
R
A
T
G
K
S
R
G
I
L
K
E
G
Q
----
K
L
L
----------
L
R
E
D
-------------------------------------------------------------------------------------------
21
PsiBlast_CBE
67.82
40%
-11
- C4 -
4Q48
1
?
B:
[8-513]
-
L
H
D
R
A
L
H
L
L
Q
T
I
W
G
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
-
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
L
L
R
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
N
G
V
R
A
A
F
L
N
S
T
L
L
P
H
E
---
A
----
R
E
V
E
D
A
L
--
L
--
R
G
D
L
D
L
L
Y
V
A
P
E
R
L
-
L
M
P
-
R
-
T
L
-----
D
L
L
E
R
A
-
P
V
A
L
F
A
---
I
D
E
A
H
C
V
S
Q
W
G
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
A
E
R
F
P
E
L
P
R
V
-
A
L
T
A
T
A
D
E
R
T
R
A
D
I
K
S
V
L
R
L
E
D
A
P
Q
F
V
S
S
F
D
R
P
N
I
Q
Y
R
V
G
L
K
D
S
P
----
K
--
T
Q
L
L
H
--
F
I
R
-
E
--
E
-
H
P
-
G
--
D
A
G
I
V
Y
C
L
S
R
K
S
V
E
E
T
A
K
W
L
Q
A
Q
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
-
E
E
G
V
I
V
C
A
T
V
A
-----
D
K
P
N
V
R
F
V
A
H
L
D
L
P
K
S
M
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
S
T
A
W
M
V
Y
G
L
S
D
V
V
N
V
R
R
M
L
A
--
Q
S
D
A
P
E
E
-
V
K
R
V
E
A
S
K
L
D
A
L
L
T
Y
C
-
E
A
-
A
T
C
R
R
Q
V
L
L
H
Y
F
G
E
-
E
--
L
--
S
E
P
C
-----
G
N
-----
C
D
V
C
L
N
P
P
--
R
V
R
D
L
T
R
E
A
Q
M
A
L
S
---
A
T
------
I
R
T
--
G
N
R
F
G
A
A
H
L
T
D
V
L
L
G
R
E
T
D
K
V
L
A
Q
G
H
H
Q
L
P
T
F
G
V
G
K
-
E
H
D
E
K
L
W
R
S
V
L
--
R
Q
L
V
S
L
G
Y
L
S
A
D
------
D
--
H
---
F
--
G
L
R
A
T
G
K
S
R
G
I
L
K
E
G
Q
----
K
L
L
----------
L
R
E
D
T
------------------------------------------------------------------------------------------
47
HHSearch
60.25
30%
-18
- C4 -
2V1X
7
RECQ1_HUMAN
A:
[29-545]
-
S
G
-
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
-
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
---
V
----
K
W
V
H
A
E
M
V
N
K
--
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-
A
K
S
-
K
M
F
M
S
R
L
E
-
K
A
Y
E
A
R
-
R
F
T
R
I
A
---
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
I
L
K
R
Q
F
P
-
N
A
S
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
Y
E
V
-
R
Q
K
P
S
N
T
E
D
F
--
I
E
D
I
V
--
K
L
I
-
N
--
G
R
Y
K
-
G
--
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
-
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
F
-
R
I
S
S
M
V
--
V
M
E
N
-------
V
G
Q
Q
K
L
Y
E
M
V
S
Y
C
-
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
-
V
W------
A
C
N----
K
M
-----
C
D
N
C
C
K
D
S
A
F
E
R
K
N
I
T
E
Y
C
R
D
L
I
K
I
L
K
Q
A
------
E
E
L
--
N
E
K
L
T
P
L
K
L
I
D
S
W
M
G
K
G
A
A
K
--------
L
R
V
A
G
V
V
A
P
T
L
P
R
E
D
L
E
K
I
I
--
A
H
F
L
I
Q
Q
Y
L
K
E
D
------
Y
S
F
T
AY
A
T
I
S
Y
L
K
I
G
P
K
A
N
L
L
N
N
-
E
A
----
H
A
I
----------
T
M
Q
V
T
K
-----------------------------------------------------------------------------------------
11
PsiBlast_PDB
59.20
38%
-2
- C4 -
2WWY
6
RECQ1_HUMAN
A:
[31-436]
----
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
-
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
---
V
K
W
V
H
A
E
M
V
N
----
K
--
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-
A
K
S
-
K
-
M
F
M
S
R
L
E
K
A
Y
E
A
R
-
R
F
T
R
I
A
---
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
I
L
K
R
Q
F
P
N
A
S
L
I
-
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
----
T
--
E
D
F
I
E
--
D
I
V
-
K
L
I
N
-
G
R
-
Y
KG
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
-
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
-----
F
R
I
--
S
S
M
V
V
M
E
-
N
V
G
Q
--
Q
K
L
Y
E
M
V
S
Y
C
-
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
--
N
--
S
E
A
C
-----
N
K
M----
C
D
N
C
C
K
D
S
--
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
58.39
38%
-8
- C4 -
4U7D
1
RECQ1_HUMAN
D:
[31-436]
----
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
-
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
---
V
KWVH
A
E
M
V
N
----
K
--
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-
A
K
S
-
K
-
M
F
MSRLE
K
A
Y
E
A
R
-
R
F
T
R
I
A
---
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
I
L
K
R
Q
F
P
N
A
S
L
I
-
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
----
T
--
E
D
F
I
E
--
D
I
V
-
K
LI
N
-
G
R
-
Y
KG
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
-
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
-----
F
R
I
--
S
S
M
V
V
M
E
-
N
V
G
Q
--
Q
K
L
Y
E
M
V
S
Y
C
-
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
--
N
--
S
E
A
C
-----
N
K
M----
C
D
N
C
C
K
D
S
--
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
58.17
38%
-5
- C4 -
4U7D
1
RECQ1_HUMAN
B:
[31-436]
----
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
-
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
---
V
K
W
V
H
A
E
M
V
N
----
K
--
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-
A
K
S
-
K
-
M
F
M
S
R
L
E
K
A
Y
E
A
R
-
R
F
T
R
I
A
---
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
I
L
K
R
Q
F
P
N
A
S
L
I
-
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
----
T
--
E
D
F
I
E
--
D
I
V
-
K
L
I
N
-
G
R
-
Y
KG
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
-
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
-----
F
R
I
--
S
S
M
V
V
M
E
-
N
V
G
Q
--
Q
K
L
Y
E
M
V
S
Y
C
-
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
-------
A
C
-----
N
K
M----
C
D
N
C
C
K
D
S
--
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
57.73
38%
-7
- C4 -
4U7D
1
RECQ1_HUMAN
C:
[31-436]
----
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
-
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
---
V
KWVH
A
E
M
V
N
----
K
--
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-
A
K
S
-
K
-
M
F
MSRLE
K
A
Y
E
A
R
-
R
F
T
R
I
A
---
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
I
L
K
R
Q
F
P
N
A
S
L
I
-
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
----
T
--
E
D
F
I
E
--
D
I
V
-
K
LI
N
-
G
R
-
Y
KG
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
-
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
-----
F
R
I
--
S
S
M
V
V
M
E
-
N
V
G
Q
--
Q
K
L
Y
E
M
V
S
Y
C
-
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
--
N
--
S
E
A
C
-----
N
K
M----
C
D
N
C
C
K
D
S
--
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
57.72
38%
-7
- C4 -
2WWY
7
RECQ1_HUMAN
B:
[31-436]
----
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
-
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
---
V
K
W
V
H
A
E
M
V
N
----
K
--
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-
A
K
S
-
K
-
M
F
M
S
R
L
E
K
A
Y
E
A
R
-
R
F
T
R
I
A
---
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
I
L
K
R
Q
F
P
N
A
S
L
I
-
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
----
T
--
E
D
F
I
E
--
D
I
V
-
K
L
I
N
-
G
R
-
Y
KG
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
-
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
-----
F
R
I
--
S
S
M
V
V
M
E
-
N
V
G
Q
--
Q
K
L
Y
E
M
V
S
Y
C
-
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
--
N
--
S
E
A
C
-----
N
K
M----
C
D
N
C
C
K
D
S
--
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
57.69
38%
-6
- C4 -
2V1X
9
RECQ1_HUMAN
B:
[31-436]
----
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
-
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
---
V
KWVH
A
E
M
V
N
----
K
--
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-
A
K
S
-
K
-
M
F
MSRLE
K
A
Y
E
A
R
-
R
F
T
R
I
A
---
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
I
L
K
R
Q
F
P
N
A
S
L
I
-
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
----
T
--
E
D
F
I
E
--
D
I
V
-
K
LI
N
-
G
R
-
Y
KG
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
-
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
-----
F
R
I
--
S
S
M
V
V
M
E
-
N
V
G
Q
--
Q
K
L
Y
E
M
V
S
Y
C
-
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
-------
A
C
-----
N
K
M----
C
D
N
C
C
K
D
S
--
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.12
38%
-5
- C4 -
2V1X
5
RECQ1_HUMAN
A:
[31-436]
----
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
-
V
T
M
A
G
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
---
V
K
W
V
H
A
E
M
V
N
----
K
--
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-
A
K
S
-
K
-
M
F
M
S
R
L
E
K
A
Y
E
A
R
-
R
F
T
R
I
A
---
V
D
E
V
H
C
C
S
Q
W
G
H
D
F
R
P
D
Y
K
A
L
G
I
L
K
R
Q
F
P
N
A
S
L
I
-
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
N
R
P
N
L
Y
Y
E
V
R
Q
K
P
S
N
----
T
--
E
D
F
I
E
--
D
I
V
-
K
L
I
N
-
G
R
-
Y
KG
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
-
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
I
-----
F
R
I
--
S
S
M
V
V
M
E
-
N
V
G
Q
--
Q
K
L
Y
E
M
V
S
Y
C
-
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
-------
A
C
-----
N
K
M----
C
D
N
C
C
K
D
S
--
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------