@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu19440: (2016-07-01 )
MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSPADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLSIAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKTRVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKNAPFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIASHQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAACILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLAAAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQHI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60...----.....70........80........90........100.......110..-.....120.......130.......140..---.....150.......160.......170.......180.......190.......200.......-210....-...220.......230.......240.....-------..250.......260......-.270.......280...-----....290........300.......310.......320.......330.......340.......350---------...---.....360.......370.......380.......390......-.400....--...410---..-----..--.....420.....-..430.....---..440.......450----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKE
T
Q
N
A
R
E
K
I
K
Q
L
L
H
I
L
I
P
I
F
I
T
Q
A
G
L
S
L
I
T
F
L
D
T
V
MSGKV
S
P
A
D
L
A
G
V
AI
G
S
S
L
W
T
P
V
Y
T
G
L
----
A
G
I
L
M
A
V
T
P
I
V
A
Q
L
LGA
E
K
KQKI
P
F
T
V
L
Q
A
V
Y
V
A
A
L
L
S
I
A
V
L
V
I
G
Y
A
A
V
D
-
L
I
L
G
RLNL
D
I
H
V
H
Q
I
A
K
H
F
L
G
F
L
S
L
G
I
F
P
L
---
F
V
Y
T
V
L
R
S
F
I
D
S
LGK
T
R
V
T
M
M
I
T
LSSL
P
I
N
F
V
L
N
Y
V
F
I
F
GKFGMPALG
G
V
G
A
G
L
A
S
A
L
T
Y
W
C
I
C
I
-
I
S
F
F
I
IH-KNAPFSEY
G
I
F
L
T
M
YKF
S
W
K
A
C
K
N
L
L
K
IGLP-------I
G
F
A
V
F
FE
T
S
I
F
A
A
V
T
L
L
M
SH-F
H
T
V
T
I
A
S
H
Q
A
A
M
N
F
A
S
-----
L
L
Y
M
LP-LS
V
S
M
A
L
T
I
V
V
GFEAGA
A
R
F
KDAR
S
Y
S
L
I
G
I
M
M
A
I
G
F
S
L
F
T
A
A
C
I
L
L
F
R
E
Q
I
AGMYTSD
P
----------
D
V
L
---
R
L
T
Q
H
F
L
I
Y
A
L
F
F
Q
L
S
D
A
V
A
A
P
I
Q
G
A
L
RGYKDV
N
Y
T
L
A
A
A
F
V
S
Y
-
W
V
I
GL
P
V
G
--
Y
M
V
G
-----
T
F
-----
T
S--
L
G
A
F
G
Y
W
I
G
L
I
A
G
-
L
A
A
G
A
V
G
L
F
F
---
R
L
A
K
L
Q
K
R
Y
SQKQHI----
31
Fugue
88.75
35%
-144
- C5 -
3MKT
-
?
A:
[2-461]
E
N
S
V
H
R
Y
K
K
E
A
S
N
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
V
S
A
I
D
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
----
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
A
V
L
F
Q
T
Q
F
--
I
I
R
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
---
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
M
L
L
-
L
L
L
F
Y
I
V
-
T
S
K
R
L
A
H
V
K
V
F
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
-------
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
P
-
L
G
S
T
V
V
A
A
H
Q
V
A
L
N
F
S
S
-----
L
V
F
M
F
P
-
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
----------
V
V
V
---
A
L
A
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
-
W
V
L
G
L
P
T
G
--
Y
I
L
G
-----
M
T
NWLTE
Q
P
--
L
G
A
K
G
F
W
L
G
F
I
I
G
-
L
S
A
A
A
L
M
L
G
Q
---
R
L
Y
W
L
Q
K
Q
S
D
D
V
Q
L
H
L
A
A
K
1
PsiBlast_PDB
88.50
36%
-148
- C5 -
3MKT
-
?
A:
[9-455]
-------
K
K
E
A
S
N
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
V
S
A
I
D
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
----
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
A
V
L
F
Q
-
T
Q
-
F
I
I
R
F
M
D
V
E
---
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
M
L
L
-
L
L
L
F
Y
I
V
-
T
S
K
R
L
A
H
V
K
V
F
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
-------
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
P
-
L
G
S
T
V
V
A
A
H
Q
V
A
L
N
F
S
S
-----
L
V
F
M
F
P
-
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
----------
V
V
V
---
A
L
A
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
-
W
V
L
G
L
P
T
G
--
Y
I
L
G
M
TNWL
T
E
-----
Q
P
--
L
G
A
K
G
F
W
L
G
F
I
I
G
-
L
S
A
A
A
L
M
L
G
Q
---
R
L
Y
W
L
Q
K
Q
S
D
D
V
Q
------
2
PsiBlast_PDB
87.84
36%
-148
- C5 -
3MKU
1
?
A:
[8-454]
-------
K
K
E
A
S
N
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
V
S
A
I
D
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
----
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
A
V
L
F
Q
-
T
Q
-
F
I
I
R
F
M
D
V
E
---
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
M
L
L
-
L
L
L
F
Y
I
V
-
T
S
K
R
L
A
H
V
K
V
F
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
-------
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
P
-
L
G
S
T
V
V
A
A
H
Q
V
A
L
N
F
S
S
-----
L
V
F
M
F
P
-
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
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A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
----------
V
V
V
---
A
L
A
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
-
W
V
L
G
L
P
T
G
--
Y
I
L
G
M
TNWL
T
E
-----
Q
P
--
L
G
A
K
G
F
W
L
G
F
I
I
G
-
L
S
A
A
A
L
M
L
G
Q
---
R
L
Y
W
L
Q
K
Q
S
D
D
V
Q
------
22
HHSearch
86.77
35%
-146
- C5 -
3MKT
-
?
A:
[5-447]
---
V
H
R
Y
K
K
E
A
S
N
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
V
S
A
I
D
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
----
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
A
V
L
-
F
Q
T
Q
F
I
I
R
-
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
---
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
M
L
L
-
L
L
L
F
Y
I
V
-
T
S
K
R
L
A
H
V
K
V
F
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
-------
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
P
-
L
G
S
T
V
V
A
A
H
Q
V
A
L
N
F
S
S
-----
L
V
F
M
F
P
-
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
----------
V
V
V
---
A
L
A
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
W
V
-
L
G
L
P
T
G
--
Y
I
L
G
-----
M
T
NWLTE
Q
P
--
L
G
A
K
G
F
W
L
G
F
I
I
G
-
L
S
A
A
A
L
M
L
G
Q
---
R
L
Y
W
L
--------------
20
PsiBlast_CBE
86.31
36%
-147
- C5 -
3MKU
1
?
B:
[8-454]
-------
K
K
E
A
S
N
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
I
M
A
G
G
V
S
A
I
D
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
----
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
A
V
L
F
Q
-
T
Q
-
F
I
I
R
F
M
D
V
E
---
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
PAY
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
M
L
L
-
L
L
L
F
Y
I
V
-
T
S
K
R
L
A
H
V
K
V
F
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
-------
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
L
V
A
P
-
L
G
S
T
V
V
A
A
H
Q
V
A
L
N
F
S
S
-----
L
V
F
M
F
P
-
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
----------
V
V
V
---
A
L
A
M
Q
L
L
L
F
A
A
I
Y
Q
C
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
-
W
V
L
G
L
P
T
G
--
Y
I
L
G
MTNWL
T
E
-----
Q
P
--
L
G
A
K
G
F
W
L
G
F
I
I
G
-
L
S
A
A
A
L
M
L
G
Q
---
R
L
Y
W
L
Q
K
Q
S
D
D
V
Q
------
4
PsiBlast_PDB
77.76
33%
-143
- C5 -
4HUL
1
?
A:
[11-443]
--------
K
E
I
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
----
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
-
P
F
R
N
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
---
M
V
H
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
F
S
A
L
-
A
L
W
I
Y
I
A
-
K
E
K
F
F
R
P
F
G
L
T
A
K
F
G
K
P
D
W
A
V
F
K
Q
I
W
K
I
G
A
P
-------
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
P
-
F
G
E
D
Y
V
A
A
Q
Q
V
G
I
S
L
S
G
-----
I
L
Y
M
I
P
-
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
----------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
-
W
G
C
G
L
L
P
G
--
Y
L
L
A
-----
Y
R
-----
F
D
--
M
G
I
Y
G
F
W
T
A
L
I
A
S
-
L
T
I
A
A
V
A
L
V
W
---
C
L
E
K
---------------
21
HHSearch
77.75
33%
-157
- C5 -
5C6P
1
?
A:
[7-446]
----
S
V
F
L
K
E
I
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
----
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
P
F
R
N
-
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
---
M
V
H
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
F
S
A
L
-
A
L
W
I
Y
I
A
-
K
E
K
F
F
R
P
F
G
L
T
A
K
F
G
K
P
D
W
A
V
F
K
Q
I
W
K
I
G
A
P
-------
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
P
-
F
G
E
D
Y
V
A
A
Q
Q
V
G
I
S
L
S
G
-----
I
L
Y
M
I
P
-
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
----------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
-
W
G
C
G
L
L
P
G
--
Y
L
L
-------
A
-----
Y
R
FD
M
G
I
Y
G
F
W
T
A
L
I
A
S
-
L
T
I
A
A
V
A
L
V
W
---
C
L
E
K
Y
S
M
------------
7
PsiBlast_PDB
77.64
33%
-156
- C5 -
5C6P
1
?
A:
[11-443]
--------
K
E
I
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
----
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
-
P
F
R
N
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
---
M
V
H
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
F
S
A
L
-
A
L
W
I
Y
I
A
-
K
E
K
F
F
R
P
F
G
L
T
A
K
F
G
K
P
D
W
A
V
F
K
Q
I
W
K
I
G
A
P
-------
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
P
-
F
G
E
D
Y
V
A
A
Q
Q
V
G
I
S
L
S
G
-----
I
L
Y
M
I
P
-
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
----------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
-
W
G
C
G
L
L
P
G
--
Y
L
L
A
-----
Y
R
-----
F
D
--
M
G
I
Y
G
F
W
T
A
L
I
A
S
-
L
T
I
A
A
V
A
L
V
W
---
C
L
E
K
---------------
5
PsiBlast_PDB
76.79
33%
-141
- C5 -
4HUM
1
?
A:
[11-443]
--------
K
E
I
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
----
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
-
P
F
R
N
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
---
M
V
H
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
F
S
A
L
-
A
L
W
I
Y
I
A
-
K
E
K
F
F
R
P
F
G
L
T
A
K
F
G
K
P
D
W
A
V
F
K
Q
I
W
K
I
G
A
P
-------
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
P
-
F
G
E
D
Y
V
A
A
Q
Q
V
G
I
S
L
S
G
-----
I
L
Y
M
I
P
-
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
----------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
-
W
G
C
G
L
L
P
G
--
Y
L
L
A
-----
Y
R
-----
F
D
--
M
G
I
Y
G
F
W
T
A
L
I
A
S
-
L
T
I
A
A
V
A
L
V
W
---
C
L
E
K
---------------
6
PsiBlast_PDB
75.86
33%
-140
- C5 -
4HUN
1
?
A:
[11-443]
--------
K
E
I
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
----
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
-
P
F
R
N
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
---
M
V
H
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
F
S
A
L
-
A
L
W
I
Y
I
A
-
K
E
K
F
F
R
P
F
G
L
T
A
K
F
G
K
P
D
W
A
V
F
K
Q
I
W
K
I
G
A
P
-------
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
P
-
F
G
E
D
Y
V
A
A
Q
Q
V
G
I
S
L
S
G
-----
I
L
Y
M
I
P
-
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
----------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
-
W
G
C
G
L
L
P
G
--
Y
L
L
A
-----
Y
R
-----
F
D
--
M
G
I
Y
G
F
W
T
A
L
I
A
S
-
L
T
I
A
A
V
A
L
V
W
---
C
L
E
K
---------------
3
PsiBlast_PDB
75.41
33%
-143
- C5 -
4HUK
1
?
A:
[11-443]
--------
K
E
I
R
L
L
T
A
L
A
L
P
M
L
L
A
Q
V
A
Q
V
G
I
G
F
V
D
T
V
M
A
G
G
A
G
K
E
D
L
A
A
V
A
L
G
S
S
A
F
A
T
V
Y
I
T
F
----
M
G
I
M
A
A
L
N
P
M
I
A
Q
L
Y
G
A
G
K
T
G
E
A
G
E
T
G
R
Q
G
I
W
F
G
L
I
L
G
I
F
G
M
I
L
M
W
A
A
I
T
-
P
F
R
N
W
L
T
L
S
D
Y
V
E
G
T
M
A
Q
Y
M
L
F
T
S
L
A
M
P
A
A
---
M
V
H
R
A
L
H
A
Y
A
S
S
L
N
R
P
R
L
I
M
L
V
S
F
A
A
F
V
L
N
V
P
L
N
Y
I
F
V
Y
G
K
F
G
M
P
A
L
G
G
A
G
C
G
V
A
T
M
A
V
F
W
F
S
A
L
-
A
L
W
I
Y
I
A
-
K
E
K
F
F
R
P
F
G
L
T
A
K
F
G
K
P
D
W
A
V
F
K
Q
I
W
K
I
G
A
P
-------
I
G
L
S
Y
F
L
E
A
S
A
F
S
F
I
V
F
L
I
A
P
-
F
G
E
D
Y
V
A
A
Q
Q
V
G
I
S
L
S
G
-----
I
L
Y
M
I
P
-
Q
S
V
G
S
A
G
T
V
R
I
G
F
S
L
G
R
R
E
F
S
R
A
R
Y
I
S
G
V
S
L
V
S
G
W
V
L
A
V
I
T
V
L
S
L
V
L
F
R
S
P
L
A
S
M
Y
N
D
D
P
----------
A
V
L
---
S
I
A
S
T
V
L
L
F
A
G
L
F
Q
P
A
D
F
T
Q
C
I
A
S
Y
A
L
R
G
Y
K
V
T
K
V
P
M
F
I
H
A
A
A
F
-
W
G
C
G
L
L
P
G
--
Y
L
L
A
-----
Y
R
-----
F
D
--
M
G
I
Y
G
F
W
T
A
L
I
A
S
-
L
T
I
A
A
V
A
L
V
W
---
C
L
E
K
---------------
23
HHSearch
68.73
16%
-183
- C5 -
4Z3N
7
?
A:
[25-456]
------
D
G
S
L
Y
K
L
L
L
R
M
A
L
P
M
F
V
G
M
L
T
Q
V
T
Y
A
I
A
D
I
F
W
L
S
H
---
G
I
I
A
G
V
G
L
V
F
P
V
G
M
G
L
F
A
I
A
----
N
G
I
Q
I
G
M
G
S
L
L
S
R
A
I
G
M
Q
R
L
D
R
A
Q
R
I
L
S
V
G
I
I
I
A
L
F
F
A
I
V
I
T
V
L
G
Y
V
Y
A
Q
P
L
L
R
-
S
L
G
A
T
K
S
I
I
G
Y
A
T
E
F
Y
Y
Y
S
L
L
T
V
F
S
I
---
M
L
I
G
V
M
M
G
L
F
Q
G
A
G
K
I
M
V
I
M
K
A
S
L
L
G
A
L
V
N
I
M
L
D
P
I
M
I
F
V
----
F
D
F
G
V
K
G
V
A
L
A
S
F
L
A
Q
L
S
M
V
A
-
Y
F
I
Y
T
L
M
-
G
----------------
S
W
K
I
Y
R
E
F
L
S
V
G
M
A
-------
Q
M
L
M
Q
L
I
I
A
V
G
I
V
I
Y
N
F
F
I
V
R
-
L
D
V
N
A
M
A
A
F
T
L
T
G
R
I
D
Y
-----
F
I
I
T
P
M
-
L
A
I
A
T
A
L
L
T
V
V
G
Q
N
W
G
H
G
N
V
T
R
T
L
N
A
Y
W
A
A
V
A
L
A
F
S
I
V
L
V
L
A
V
M
H
I
V
L
A
P
W
M
Y
P
L
F
T
R
V
V
----------
A
V
S
---
D
Y
A
V
L
Q
T
R
I
M
A
L
A
L
P
F
V
A
I
S
L
L
A
S
E
Y
Y
Q
A
I
G
K
P
W
Y
S
V
L
L
T
L
M
R
H
V
F
-
I
S
V
P
V
V
--
Y
L
L
A
-----
I
V
-----
L
E
--
M
R
I
T
G
V
Y
F
G
A
M
S
G
-
T
F
V
A
A
L
L
A
W
R
---
L
L
R
L
---------------
13
PsiBlast_PDB
67.62
22%
-140
- C5 -
3VVS
13
?
A:
[18-453]
-----------
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
----
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
-
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
---
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
V
-
K
R
D
T
Y
V
D
--
I
T
L
R
D
F
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
-------------
A
I
T
A
G
G
E
N
G
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
---I
K
G
D
L
I
----
S
A
L
---
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
---
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
-------
M
Q
V
G
F
A
Y
I
F
V
-----
H
Y
-----
T
T
--
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
------------
25
HHSearch
67.36
19%
-136
* C5 *
3W4T
9
?
A:
[14-447]
-------
G
D
P
K
K
A
I
V
R
L
S
I
A
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
----
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
S
L
F
R
-
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
---
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
T
----
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
-
F
I
A
Y
W
L
F
V
K
R
D
T
Y
V
D
I
T
L
--
R
D
F
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
-------
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
A
I
T
A
G
G
E
N
G
V
A
V
F
T
S
A
W
R
I
T
M
-----
L
G
I
V
P
I
-
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
---------------VI
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
-
L
V
M
Q
V
G
F
A
--
Y
I
F
V
-----
H
Y
-----
T
T
--
L
G
L
R
G
V
W
I
G
I
V
I
G
-
N
M
V
A
A
I
V
G
F
L
---
W
G
R
M
R
--------------
12
PsiBlast_PDB
66.64
22%
-141
- C5 -
3VVR
4
?
A:
[18-453]
-----------
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
----
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
-
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
---
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
V
-
K
R
D
T
Y
V
D
--
I
T
L
R
D
F
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
-------------
A
I
T
A
G
-
E
N
G
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
--I
K
G
D
L
I
----
S
A
L
---
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
---
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
-------
M
Q
V
G
F
A
Y
I
F
V
-----
H
-----------
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
------------
9
PsiBlast_PDB
66.30
22%
-146
- C5 -
3VVN
12
?
A:
[18-453]
-----------
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
----
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
-
S
L
F
R
S
M
G
A
--
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
---
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
V
-
K
R
D
T
Y
V
D
--
I
T
L
R
D
F
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
-------------
A
I
T
A
G
G
E
N
G
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
---AQVI
K
G
D
L
I
-
S
A
L
---
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
---
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
-------
M
Q
V
G
F
A
Y
I
F
V
-----
H
Y
-----
T
T
--
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
------------
15
PsiBlast_PDB
66.09
22%
-134
- C5 -
3W4T
9
?
A:
[18-453]
-----------
K
A
I
V
R
L
S
I
A
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
----
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
-
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
---
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
V
-
K
R
D
T
Y
V
D
--
I
T
L
R
D
F
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
-------------
A
I
T
A
G
G
E
N
G
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
--VI
K
G
D
L
I
---
S
A
L
---
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
---
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
-------
M
Q
V
G
F
A
Y
I
F
V
-----
H
Y
-----
T
T
--
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
------------
8
PsiBlast_PDB
65.63
22%
-144
- C5 -
4MLB
22
?
A:
[25-460]
-----------
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
----
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
-
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
---
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
V
-
K
R
D
T
Y
V
D
--
I
T
L
R
D
F
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
-------------
A
I
T
A
G
G
E
N
G
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
T
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
S
E
SAQVI
K
G
D
L
I
S
A
L
---
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
---
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
-------
M
Q
V
G
F
A
Y
I
F
V
-----
H
Y
-----
T
T
--
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
------------
14
PsiBlast_PDB
65.49
22%
-143
- C5 -
3WBN
6
?
A:
[18-453]
-----------
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
----
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
-
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
---
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
V
-
K
R
D
T
Y
V
D
--
I
T
L
R
D
F
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
-------------
A
I
T
A
G
G
E
N
G
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
S
E
SAQVI
K
G
D
L
I
S
A
L
---
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
---
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
-------
M
Q
V
G
F
A
Y
I
F
V
-----
H
Y
-----
T
T
--
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
------------
10
PsiBlast_PDB
65.23
22%
-136
- C5 -
3VVO
10
?
A:
[18-453]
-----------
K
A
I
V
R
L
S
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
----
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
-
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
---
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
----
T
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
V
-
K
R
D
T
Y
V
D
--
I
T
L
R
D
F
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
V
-------------
A
I
T
A
G
G
E
N
G
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
--IK
G
D
L
I
----
S
A
L
---
R
T
L
P
V
F
L
V
L
T
P
F
G
M
M
T
S
A
M
---
F
Q
G
I
G
E
G
E
K
S
L
I
L
T
I
F
R
T
L
V
-------
M
Q
V
G
F
A
Y
I
F
V
-----
H
Y
-----
T
T
--
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
R
M
R
I
S
A
L
K
K
------------