@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu21920: (2016-07-03 )
MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDEHQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKEKLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNVKELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDCMITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTSLLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS
Atome Classification :
(20 SA)
.........10.-.---------------.---.---....20........30.-...-.-------...40........50.......-----------.60........70........80........90....----....100...--....110-..-...-.--.--.120.-...-...130--.------------..--....----.----140---------.--------.---.---....----..150..-.....160...-...-------------.170..--...-.-.180....-.-.--------.--190......-.---------200.....------..210..---......220.---..----.-.---.--------.230--.........240-...------......250-..--.--------....260---..-------.--.--....270......-----------.--------------280---.........290......--.-300.-....-..310....-...320-.--------------------.--.---.....330.....--.--.340.......350.-......360.......370.......380---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNTN
K
R
V
L
I
L
T
A-N---------------Y---G---NG
H
V
Q
V
A
K
T
L
Y
E
Q
C
V
R
L-GFQ-H-------
V
T
V
S
N
L
YQESN
P
I
V
S
E
V
T
Q
Y
L
Y
-----------
L
KSF
S
I
G
K
Q
F
Y
R
L
F
Y
Y
G
V
D
K
IYNK
R
K
F
N
I
Y
F
KMG
N
K
R
----
L
G
E
L
V
D
EHQP--
D
I
I
I
NT--F
P
-
M
I
V-V--
P
--
E
Y
R
R
R-TGR-VIP
T
F
---
N
------------
V
M
--
T
D
F
C
----
L
----
H
-----------
K
--------
I
---
W
---VHEN----VD
K
Y
Y
V
A
-
T
D
Y
V
K
E
K
L
L
E
I-GTH-------------PSN
V
K
I
--
T
G
I
-P-IRPQ
F
E
ES-M-P--------V--GP
I
Y
K
KYNL-S---------PN
K
K
V
L
L
I
------
M
AGA-
H
G
---
V
L
K
N
V
K
E
L
C
E
---
N
L
----V-K---D--------D
Q
----
V
Q
V
V
V
V
CGK
N
---
T
A
L
------
K
E
S
L
S
A
LEA-EN--G--------
D
K
L
K
V
L
----
G
Y
-------
V
--
E
--
R
I
D
E
L
F
R
I
T
D
C
M
I-----------T--------------K-----PG
G
I
T
L
T
E
ATAIG
V
P
V
I
L
--Y-KPVP-GQEK-ENANFFEDR-G
A
A
I
V
--V--------------------N--
R
---
H
E
E
I
L
E
S
V
T
S
L
LA--
D
--
E
D
T
L
H
R
M
K
K
N
I
K
D
LH-LANS
S
E
V
I
L
E
D
I
L
K
E
S
E
M
M
T
A
K
Q
K
A
KVLS---
76
Fugue
80.06
26%
-11
- C2 -
4X1T
10
?
A:
[6-389]
----
K
K
V
L
I
L
M
S
-
D
---------------
T
---
G
---
G
G
H
------------------------------------------------------------
R
A
S
A
E
A
I
R
A
A
F
N
Q
E
F
--------
G
D
E
Y
Q
V
F
I
T
-----------------
Q
P
--
D
I
I
I
S
V
--
H
P
L
M
Q
H
-
V
--
P
--
L
R
V
L
R
-
S
K
G
-
L
L
K
K
I
---
V
------------
F
T
--
T
V
I
T
DLST
C
----
H
-----------
P
--------
T
---
W
---
F
H
K
L
----
V
T
R
C
Y
C
P
-
S
T
E
V
A
K
R
A
Q
K
A
-
G
L
E
-------------
T
S
Q
I
K
V
--
Y
G
L
-
P
-
V
R
P
S
F
V
K
P
V
R
-
P
--------
K
--
V
E
L
R
R
E
L
G
M
-
D
---------
E
N
L
P
A
V
L
L
------
M
G
G
G
-
E
G
MGP
I
E
A
T
A
R
A
L
A
D
---
A
L
----
Y
-
D
---
K
--------
N
L
GEAV
G
Q
V
L
I
I
C
G
R
N
---
K
K
L
------
Q
S
K
L
S
S
L
D
W
-
K
I
------------
P
V
Q
V
K
----
G
F
-------
I
--
T
--
K
M
E
E
C
M
G
A
C
D
C
I
I
-----------
T
--------------
K
-----
A
G
P
G
T
I
A
E
A
M
I
R
G
L
P
I
I
L
--
N
-
G
Y
I
A
-
G
Q
E
A
-
G
N
V
P
Y
V
V
E
N
-
G
C
G
K
F
--
S
--------------------
K
--
S
---
P
K
E
I
S
K
I
V
A
D
W
F
G
P-
A
--
S
K
E
L
E
I
M
S
Q
N
A
L
R
L
A
-
K
P
E
A
V
F
K
I
V
H
D
M
H
E
L
V
R
K
K
N
S
-----------
56
HHSearch
72.08
23%
9
- C2 -
4X1T
10
?
A:
[6-389]
----
K
K
V
L
I
L
M
S
-
D
---------------
T
---
G
---
G
G
H
R
A
S
A
E
A
I
R
A
A
F
N
Q
E
F
G
D
E
Y
Q
-------
V
F
I
T
------------------------------------------------------------------------------
Q
P
--
D
I
I
I
S
V
--
H
P
-
L
M
Q
-
H
--
V
P
L
R
V
L
R
S
-
K
G
L
-
L
K
K
I
V
---
F
------------
T
T
V
I
T
D
L
S
----
T
C---
H
-----------
P
--------
T
---
W
---
F
H
K
L
----
V
T
R
C
Y
C
P
-
S
T
E
V
A
K
R
A
Q
K
A
-
G
L
E
-------------
T
S
Q
I
K
V
--
Y
G
L
-
P
-
V
R
P
S
F
V
K
P
-
V
R
P
--------
K
--
V
E
L
R
R
E
L
G
M
-
D
---------
E
N
L
P
A
V
L
L
------
M
G
G
--
G
E
---
G
M
G
P
I
E
A
T
A
R
---
A
L
----
A
D
A
---
L
YDKNLGEA
V
G
----
Q
V
L
I
I
C
-
G
R
N
---
K
K
L
------
Q
S
K
L
S
S
L
---
D
W
--
K
--------
I
P
V
Q
V
K
----
G
F
-------
I
--
T
--
K
M
E
E
C
M
G
A
C
D
C
I
I
-----------
T
--------------
K
-----
A
G
P
G
T
I
A
E
A
M
I
R
G
L
P
I
I
L
--
N
-
G
Y
I
A
-
G
Q
E
A
G
N
V
P
Y
V
V
E
N
--
G
C
G
K
F
--
S
--------------------
K
--
S
---
P
K
E
I
S
K
I
V
A
D
W
F
G
--
P
A-
S
K
E
L
E
I
M
S
Q
N
A
L
R
L
A
-
K
P
E
A
V
F
K
I
V
H
D
M
H
E
L
V
R
K
K
N
S
-----------
2
PsiBlast_PDB
67.68
25%
-24
- C2 -
4WYI
-
?
A:
[142-478]
----
K
K
V
L
I
L
M
S
-
D
---------------
T
---
G
---
G
G
H
R
A
S
A
-----
E
A
I
R
A
-
A
F
N
-
Q
E
FGDE
Y
Q
V
F
I
T
D
L
------------------------------------------------------------
I
A
R
E
----
I
A
Q
G
L
M
K
Y
Q
P
--
D
I
I
I
S
V
--
H
P
-
L
M
Q
H
V
--
P
--
L
R
V
L
R
-
S
K
G
-
L
L
K
K
I
V
F
T
T
------------
V
I
--
T
D
L
S
T---
C
----
H
-----------
P
--------
T
---
W
---
F
H
K
L
----
V
T
R
C
Y
C
P
-
S
T
E
V
A
K
R
A
Q
K
A
-
G
L
E
-------------
T
S
Q
I
K
V
--
Y
G
L
-
P
-
V
R
P
S
F
---------------
V
--
K
P
V
R
P
K
V
E
L
-
R
R
E
L
GMDEN
L
P
A
V
L
L
M
G
G
------
G
E
G
M
-
G
P
---
I
E
A
T
A
R
A
L
A
D
---
A
L
YDKN
L
-
G
---
E
--------
A
V
----
G
Q
V
L
I
I
C
G
R
N
---
K
K
L
------
Q
S
K
L
S
S
L
D
W
-
K
------------
I
P
V
Q
V
K
----
G
F
-------
I
--
T
--
K
M
E
E
C
M
G
A
C
D
C
I
I
-----------
T
--------------
K
-----
A
G
P
G
T
I
A
E
A
M
I
R
G
L
P
I
I
L
--
N
-
G
Y
I
A
-
G
Q
E
A
-
G
N
V
P
Y
V
V
E
N
-
G
C
G
K
F
--
S
--------------------
K
--
S
---
P
K
E
I
--------------------------------------------------------------
1
PsiBlast_PDB
65.91
25%
-37
- C2 -
4X1T
9
?
A:
[6-342]
----
K
K
V
L
I
L
M
S
-
D
---------------
T
---
G
---
G
G
H
R
A
S
A
-----
E
A
I
R
A
-
A
F
N
-
Q
E
FGDE
Y
Q
V
F
I
T
------------------------------------------------------------------------------
Q
P
--
D
I
I
I
S
V
--
H
P
-
L
M
Q
H
V
--
P
--
L
R
V
L
R
-
S
K
G
-
L
L
K
K
I
V
F
T
T
------------
V
I
--
T
D
L
S
T---
C
----
H
-----------
P
--------
T
---
W
---
F
H
K
L
----
V
T
R
C
Y
C
P
-
S
T
E
V
A
K
R
A
Q
K
A
-
G
L
E
-------------
T
S
Q
I
K
V
--
Y
G
L
-
P
-
V
R
P
S
F
---------------
V
--
K
P
V
R
P
K
V
E
L
-
R
R
E
L
GMDEN
L
P
A
V
L
L
M
G
G
------
G
E
G
M
-
G
P
---
I
E
A
T
A
R
A
L
A
D
---
A
L
YDKN
L
-
G
---
E
--------
A
V
----
G
Q
V
L
I
I
C
G
R
N
---
K
K
L
------
Q
S
K
L
S
S
L
D
W
-
K
------------
I
P
V
Q
V
K
----
G
F
-------
I
--
T
--
K
M
E
E
C
M
G
A
C
D
C
I
I
-----------
T
--------------
K
-----
A
G
P
G
T
I
A
E
A
M
I
R
G
L
P
I
I
L
--
N
-
G
Y
I
A
-
G
Q
E
A
-
G
N
V
P
Y
V
V
E
N
-
G
C
G
K
F
--
S
--------------------
K
--
S
---
P
K
E
I
--------------------------------------------------------------
77
Fugue
65.74
15%
-21
- C2 -
1F0K
-
MURG_ECOLI
A:
[7-357]
-----
K
R
L
M
V
M
A
-
G
---------------
G
---
T
---
G
G
H
V
F
P
G
L
A
V
A
H
H
L
M
A
Q
-
G
W
Q
-
V
-------
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
--
I
E
-----------
I
D
F
I
R
I
S
G
-------
L
R
G
K
G
I
K
A
L
I
A
A
P
L
R
I
F
N
A
W
R
Q
----
A
R
A
I
M
K
A
Y
K
P
--
D
V
V
L
G
M
--
G
G
-
Y
V
S
-
G
--
P
--
G
G
L
A
A
-
W
S
L
-
G
I
P
--------------------------------------------------------
V
---
V
---
L
H
E
Q
NGIA
G
L
T
N
K
W
L
-
A
K
I
A
T
K
V
M
Q
A
F
-
P
G
A
-------------
F
P
N
A
E
V
--
V
G
N
-
P
-
V
R
T
D
V
L
-----
A
--------
L
--
P
L
P
Q
Q
R
L
A
G
-
R
---------
E
G
P
V
R
V
L
V
------
V
G
G
S
-
Q
G
---
A
R
I
L
N
Q
T
M
P
Q
---
V
A
----
A
-
K
L
--
G
--------
D
S
----
V
T
I
W
H
Q
S
G
K
G
---
S
-
Q
------
Q
S
V
E
Q
A
Y
A
E
-
A
G
--
Q
--------
P
Q
H
K
V
T
----
E
F
-------
I
--
D
--
D
M
A
A
A
Y
A
W
A
D
V
V
V
-----------
C
--------------
R
-----
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
VP
F
-
Q
H
K
D
-
R
Q
Q
Y
-
W
N
A
L
P
L
E
K
A
-
G
A
A
K
I
--
I
--------------------
E
--
Q
---
P
Q
L
S
V
D
A
V
A
N
T
L
A
G
W
S
--
R
E
T
L
L
T
M
A
E
R
A
R
A
A
S
-
I
P
D
A
T
E
R
V
A
N
E
V
S
R
V
A
R
A
L
-------------
63
HHSearch
64.48
15%
-46
- C2 -
3S2U
1
MURG_PSEAE
A:
[3-355]
----
G
N
V
L
I
M
A
G
-
G
---------------
T
-------
G
G
H
V
F
P
A
L
A
C
A
R
E
F
Q
A
R
-
G
Y
--
A
-------
V
H
W
L
G
T
P
R
G
--
I
E
N
D
L
V
P
K
A
G
L
-----------
P
L
H
L
I
Q
---------------
A
----
P
L
E
-
L
L
K
S
L
F
Q
----
A
L
R
V
I
R
Q
L
R
P
--
V
C
V
L
G
L
--
G
G
-
Y
V
T
-
G
--
P
G
G
L
A
A
R
L
-
N
---
G
V
P
L
V
---
I
------------
H
E
--
Q
N
A
V
----
A
----
G
T
A
---------
N
--------
R
---
S
---
L
A
P
I
----
A
R
R
V
--------
C
E
A
F
P
D
T
-
F
P
A
----------------
R
L
T
--
T
G
N
-
P
-
V
R
G
E
L
F
L
D
---
A
--------
H
----
A
R
A
P
L
---
T
---------
G
R
R
V
N
L
L
V
------
L
G
G
S
-
L
G
---
A
E
P
L
N
K
L
L
P
E
---
A
L
----
A
Q
V
---
P
LEI-----
R
P
----
A
I
R
H
Q
-
A
G
R
Q
---
H
A
E
-------
I
T
A
E
R
-
Y
R
-
T
V
--
A
--------
V
E
A
D
V
A
----
P
F
-------
I
--
S
--
D
M
A
A
A
Y
A
W
A
D
L
V
I
-----------
C
--------------
R
-----
A
G
A
L
T
V
S
E
L
T
A
A
G
L
P
A
F
L
--
V
-
P
---D
D
H
Q
T
-
R
N
A
E
F
L
V
R
S
-
G
A
G
R
L
--
L
--------------------
P
QK
S
TG-
A
A
E
L
A
A
Q
L
S
E
V
L
M
--
H
--
P
E
T
L
R
S
M
A
D
Q
A
R
S
L
A
-
K
P
E
A
T
R
T
V
V
D
A
C
L
E
V
A
----------------
65
HHSearch
60.34
15%
-17
- C2 -
3OY2
-
?
A:
[1-392]
----
M
K
L
I
I
V
G
A
-
H
SS-------------
V
---
P
---
S
G
Y
G
R
V
M
R
A
I
V
P
R
I
S
K
--
A
H
--
E
-------
V
I
V
F
G
I
H
A
F
G
R
S
V
H
A
N
I
E
--
E
F
---------------
D
A
Q
T
A
E
---
H
V
R
G
L
N
---------
E
-
Q
G
F
Y
Y
S
G
----
L
S
E
F
I
D
V
H
K
P
--
D
I
V
M
I
Y
--
N
D
-
P
I
V
-
I
G
N
Y
L
L
A
M
G
K
C
--
S
H
-
R
T
K
I
V
---
L
------------
Y
V
--
D
L
V
S
----
K
----
N
IRENLW-----
W
--------
I
---
F
---
S
H
P
K
----
V
V
G
V
M
A
M
-
S
K
C
W
I
S
D
I
C
N
Y
-
G
C
--------------
K
V
P
I
N
I
--
V
S
H
-
F
-
V
D
T
K
T
I
Y
D
---
A
--------------
R
K
L
V
G
L
-
S
EY-------
N
D
D
V
L
F
L
N
------
M
N
-
R
-
N
T
---
A
R
K
R
L
D
I
Y
V
L
---
A
A
----
A
R
F
---
I
S
K
Y
-----
P
D
----
A
K
V
R
F
L
-
C
N
S
---
H
H
E
SKFD
L
H
S
I
A
L
R
E
L
V
A
S
G
V
--
D
--------
N
V
F
T
H
L
----
N
K
IMINR
T
V
L
T
D
E
--
R
V
D
M
M
Y
N
A
C
D
V
I
V
-----------
N
CSSG----------
E
-----
G
F
G
L
C
S
A
E
G
A
V
L
G
K
P
L
I
I
--
S
-
A
V
G
--
G
A
-----
D
D
Y
F
S
G
D
--
C
V
Y
K
--
I
K
PS
A
W
I
S
VDDRDGI
G
G
I
E
G
I
I
--
D
---
V
D
D
L
V
E
A
F
T
F
F
-
K
--
D
--
E
K
N
R
K
E
Y
G
K
R
V
Q
D
F
V
K
T
K
P
T
W
D
D
I
S
S
D
I
I
D
F
F
N
S
L
L
R
-----------
74
HHSearch
59.82
16%
-7
- C2 -
2X6Q
-
TRET_PYRHO
A:
[40-415]
---
G
R
S
F
V
H
V
N
S
T
S
---------------
F
---
G
---
G
G
V
A
E
I
L
H
S
L
V
P
L
L
R
S
I
-
G
I
--
E
-------
A
R
W
F
V
I
E
G
-
P
T
E
F
F
N
-
V
T
-
K
T
F
-----------
H
N
A
L
Q
G
N
E
S
L
-----
K
L
T
E
E
M
------
K
E
L
Y
L
N
V
N
R
E
----
N
S
K
F
I
D
L
S
S
F
--
D
Y
V
L
V
H
--
D
P
-
Q
P
A
-
A
--
L
I
-
E
F
Y
E
--
K
---
K
S
P
W
L
---
W
------------
R
C
--
H
I
D
L
----
S
S---
P
N
R
---------
E
F
W
------
E
F
L
R
R
---
F
V
E
K
----
Y
D
R
Y
I
F
H
L
P
E
Y
V
Q
P
E
------
L
D
-------------
R
N
K
A
V
I
--
M
P
P
-
S
-
I
D
P
L
S
E
K
N
-
V
-
E
LK
Q
T
E
---
I
--
L
R
I
L
E
R
F
D
V
-
D
---------
P
E
K
P
I
I
T
Q
------
V
S
-
R
-
F
D
---
P
W
K
G
I
F
D
V
I
E
---
I
Y
----
R
K
V
---
K
E
KI-----
P
G
----
V
Q
L
L
L
V
G
V
M
A
HDD
P
E
G
------
W
I
Y
F
E
K
T
L
R
-
K
I
GE
D
--------
Y
D
V
K
V
L
TNLI
G
V
-------
H
A
-
R
--
E
V
N
A
F
Q
R
A
S
D
V
I
L
-----------
Q
MSIR----------
E
-----
G
F
G
L
T
V
T
E
A
M
W
K
G
K
P
V
I
G
--
R
-
A
V
G
--
G
I
-----
K
F
Q
I
V
D
G
-
E
T
G
F
L
--
V
--------------------
R
--
D
---
A
N
E
A
V
E
V
V
L
Y
L
L
K
--
H
--
P
E
V
S
K
E
M
G
A
K
A
K
E
R
V
R
K
N
F
I
I
T
K
H
M
E
R
Y
L
D
I
L
N
S
L
G
------------
79
Fugue
58.86
14%
-17
- C2 -
1F0K
-
MURG_ECOLI
A:
[7-357]
-----
K
R
L
M
V
M
A
-
G
---------------
G
---
T
---
G
G
H
V
F
P
G
L
A
V
A
H
H
L
M
A
Q
-
G
W
Q
-
V
-------
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
I
E
I
D
F
I
R
I
S
GLRGKG
I
K
A
L
I
A
A
P
L
R
I
F
N
A
W
R
Q
A
R
A
I
M
K
A
Y
K
P
D
V
V
L
G
M
G
G
-
Y
V
S
G
P
G
G
L
A
A
W
S
L
G
I
--
P
V
V
L
H
E
--
Q
N
-
G
I
A
-
G
------------------------------------------------------------------------------------
L
T
----
N
K
W
L
A
K
----------------
I
AT
K
V
M
Q
AFPGAFP--
N
A
E
V
--
V
G
N
-
P
-
V
R
T
D
V
L
A
L
-
P
-
L
-------------
P
Q
Q
R
L
A
G
-
R
---------
E
G
P
V
R
V
L
V
------
V
G
G
S
-
Q
G
---
A
R
I
L
N
Q
T
M
P
Q
---
V
A
----
A
-
K
---
L
--------
G
D
----
S
V
T
I
W
H
Q
S
G
K
---
G
S
Q
------
Q
S
V
E
Q
A
Y
A
E
-
A
G
--
Q
--------
P
Q
H
K
V
T
----
E
F
-------
I
--
D
--
D
M
A
A
A
Y
A
W
A
D
V
V
V
-----------
C
--------------
R
-----
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
VP
F
-
Q
H
K
D
-
R
Q
Q
Y
-
W
N
A
L
P
L
E
K
A
-
G
A
A
K
I
--
I
--------------------
E
--
Q
---
P
Q
L
S
V
D
A
V
A
N
T
L
A
--
G
WS
R
E
T
L
L
T
M
A
E
R
A
R
A
A
S
-
I
P
D
A
T
E
R
V
A
N
E
V
S
R
V
A
R
A
L
-------------
69
HHSearch
58.31
14%
-32
- C2 -
3DZC
2
?
A:
[24-395]
--
A
M
K
K
V
L
I
V
F
G
-
T
-----------------------
R
P
E
A
I
K
M
A
P
L
V
Q
Q
L
C
Q
D
-
N
R
F
-
V
-------
A
K
V
C
V
T
G
Q
H
R
E
M
L
-
D
Q
V
L
E
-
L
F
-----------
S
I
-
T
P
D
F
D
L
N
---
I
M
E
P
G
Q
T
------
L
N
G
V
T
S
K
I
L
L
G
----
M
Q
Q
V
L
S
S
E
Q
P
--
D
V
V
L
V
H
--
G
D
-
T
A
T
-
T
--
F
A
A
S
L
A
A
Y
-
Y
-
Q
-
Q
I
P
V
G
---
H
------------
V
E
--
A
G
L
R
----
T
----
G
NIY--------
S
PW
P
E
E
G
N
R
K
---
L
---
T
A
A
L
----
T
Q
Y
H
F
A
P
-
T
D
T
S
R
A
N
L
L
Q
E
-
N
Y
N
-------------
A
E
N
I
F
V
--
T
G
N
-
T
-
V
I
D
A
L
L
A
V
-
R
-
E
K
I
H
T
D
M
D
L
Q
--
A
T
L
E
S
Q
F
P
M
L
D
---------
A
S
K
K
L
I
L
V
------
T
G
H
R
R
E
S
---
F
G
G
G
F
E
R
I
C
Q
---
A
L
----
I
T
T
---
A
E
Q
H
-----
P
E
----
C
Q
I
L
Y
P
V
H
L
N
---
P
N
V
------
R
E
P
V
N
K
L
L
K
-
G
---
V
--------
S
N
I
V
L
I
----
E
P
-------
Q
--
Q
Y
L
P
F
V
Y
L
M
D
R
A
H
I
I
L
-----------
T
--------------------
D
S
G
G
I
Q
E
E
A
P
S
L
G
K
P
V
L
V
--
M
-
R
E
T
T
-
E
R
-----
P
E
A
V
A
A
G
-
T
V
K
L
V
--
G
--------------------
T
--
N
---
Q
Q
Q
I
C
D
A
L
S
L
L
L
T
--
D
--
P
Q
A
Y
Q
A
M
S
Q
A
H
-----
N
P
Y
G
D
G
K
A
C
Q
R
I
A
D
I
L
A
---------------
84
Fugue
52.40
14%
3
- C2 -
2IW1
1
RFAG_ECOLI
A:
[2-371]
-----
I
V
A
F
C
L
Y
-
K
---------------
Y
---
F
PF-
G
G
L
Q
R
D
F
M
R
I
A
S
T
V
A
A
R
-
G
H
H
-
V
-------
R
V
Y
T
Q
S
W
E
G
D
C
P
--
K
A
F
E
L
I
Q
V
-----------
P
V
K
S
H
T
N
H
G
R
N
A
E
Y
Y
A
W
V
Q
N
H
L
K
E
H
P
A
D
R
V
V
G
F
----------
N
K
M
P
G
L
D
V
--
Y
F
A
A
D
V
--
C
Y
-
A
E
K
-
V
--
A
--
Q
E
K
G
F
-
L
Y
R
-
L
T
S
R
Y
---
R
------------
H
Y
--
A
A
F
E
----
R
----
A
-----------
T
--------
F
---
E
---
Q
G
K
S
-----
T
K
L
M
M
L
-
T
D
K
Q
I
A
D
F
Q
K
H
Y
Q
T
E
-------------
P
E
R
F
Q
I
--
L
P
P
-
G
-
I
Y
P
D
R
K
Y
S
-
E
-
Q
--------
I
--
P
N
S
R
E
I
Y
R
Q
-
K
N
GI------
K
E
Q
Q
N
L
L
L
------
Q
V
G
S
-
D
F
---
G
R
K
G
V
D
R
S
I
E
---
A
L
A
S
LP
E
-
S
---
L
--------
R
H
----
N
T
L
L
F
V
V
G
Q
D
---
K
P
R
------
K
F
E
A
L
A
E
K
L
-
G
V
--
R
--------
S
N
V
H
F
F
----
S
G
-------
R
--
N
--
D
V
S
E
L
M
A
A
A
D
L
L
L
H
PAY-------
Q
--------------
E
-----
A
A
G
I
V
L
L
E
A
I
T
A
G
L
P
V
L
T
--
T
-
A
V
C
G
-------
Y
A
H
Y
I
A
D
A
-
N
C
G
T
V
--
I
A
E
P-----------------
F
--
S
---
Q
E
Q
L
N
E
V
L
R
K
A
L
T
--
Q
--
S
P
L
R
M
A
W
A
E
N
A
R
H
Y
A
-
D
T
Q
D
L
Y
S
L
P
E
K
A
A
D
I
I
T
G
G
-------------
71
HHSearch
51.71
16%
8
- C2 -
1V4V
2
?
A:
[81-368]
---------------------------------------------------------------------------------------------------------------------------------------
P
Q
----
A
A
R
A
L
K
E
M
G
A
--
D
Y
V
L
V
H
--
G
D
-
T
L
T
T
F
--
A
V
-
A
W
A
A
F
-
L
-
E
-
G
I
P
V
G
---
H
------------
V
E
--
A
G
L
R
----
S
GNL-
K
EPF
P
E
E
A
N
---
R
--------
R
---
L
---
T
D
V
L
----
T
D
L
D
F
A
P
-
T
P
L
A
K
A
N
L
L
K
E
-
G
K
R
-------------
E
E
G
I
L
V
--
T
G
Q
T
G
-
V
D
A
V
L
L
A
A
---
K
--------
L
--
G
R
--
L
P
E
G
L
-
P
---------
E
G
P
Y
V
T
V
T
------
M
H
-
R
-
R
E
---
N
W
P
L
L
S
D
L
A
Q
---
A
L
----
K
R
V
---
A
E
A
F
-----
P
H
----
L
T
F
V
Y
P
V
H
L
N
---
P
V
V
------
R
E
A
V
F
P
V
L
K
-
G
---
V
--------
R
N
F
V
L
L
----
D
P
-------
L
E
Y
G
--
S
M
A
A
L
M
R
A
S
L
L
L
V
-----------
T
--------------
D
-----
S
-
G
G
L
Q
E
E
G
A
A
L
G
V
P
V
V
V
--
L
R
N
V
T
--
E
R
-----
P
E
G
L
-
K
A
-
G
I
L
K
L
--
A
G-------------------
T
--
D
---
P
E
G
V
Y
R
V
V
K
G
L
L
E
--
N
--
P
E
E
L
S
R
M
R
K
A
K
N
P
Y
G
-
D
G
K
A
G
L
M
V
A
R
G
V
A
W
R
L
G
L
G
-------------
60
HHSearch
51.30
14%
15
* C2 *
3OKP
1
PIMB_CORGL
A:
[4-381]
---
S
R
K
T
L
V
V
T
N
-
D
FPP------------
R
---
I
---
G
G
I
Q
S
Y
L
R
D
F
I
A
T
Q
D
P
---
E
--
S
-------
I
V
V
F
A
S
T
Q
N
A
E
E
-
A
H
A
Y
D
-
K
T
L
----------------
D
Y
E
V
I
---
R
W
P
R
S
V
M
L
-------
P
-
T
P
T
T
A
H
A
----
M
A
E
I
I
R
E
R
E
I
--
D
N
V
W
F
G
--
A
A
-
A
P
L
-
A
--
L
M
A
G
T
A
K
Q
-
A
-
G
-
A
S
K
V
I
---
A
------------
S
T
--
H
G
H
E
----
V
G
W
S
M
L
P
G
S
--------
R
Q
S
L
-----
R
---
K
---
I
G
T
E
----
V
D
V
L
T
Y
I
-
S
Q
Y
T
L
R
R
F
K
S
A
-
F
G
S
-------------
H
P
T
F
E
H
--
L
P
S
-
G
-
V
D
V
K
R
F
T
P
-
A
-
T
P
E
D
-----
K
--
S
A
T
R
K
K
L
G
F
-
T
---------
D
T
T
P
V
I
A
C
------
N
S
-
R
-
L
V
---
P
R
K
G
Q
D
S
L
I
K
---
A
M
----
P
Q
V
I
A
A
R
--------
P
D
----
A
Q
L
L
I
V
-
G
S
G
---
R
-
Y
------
E
S
T
L
R
R
L
A
T
-
D
V
--
S
--------
Q
N
V
K
F
L
----
G
R
-------
L
E
Y
Q
--
D
M
I
N
T
L
A
A
A
D
I
F
A
-----------
M
P
A
R
T
R
GGGLDV---
E
-----
G
L
G
I
V
Y
L
E
A
Q
A
C
G
V
P
V
I
A
--
G
-
T
S
G
--
G
A
-----
P
E
T
V
T
P
--
A
T
G
L
V
V
E
G
--------------------
S
--
D
---
V
D
K
L
S
E
L
L
I
E
L
L
D
--
D
--
P
I
R
R
A
A
M
G
A
A
G
R
A
H
V
E
A
E
W
S
W
E
I
M
G
E
R
L
T
N
I
L
Q
S
E
P
R
-----------
57
HHSearch
50.62
16%
-13
- C2 -
2JJM
-
BSHA_BACAN
A:
[78-374]
---------------------------------------------------------------------------------------------------------------------------------------------
M
A
E
V
A
Q
R
E
N
L
--
D
I
L
H
V
H
--
Y
A
-
I
P
H
-
A
--
I
C
A
Y
L
A
K
Q
M
I
G
E
-
R
I
K
I
V
---
T
------------
T
L
--
H
G
T
D
----
I
----
T
VLGSDPSL
N
N
L
I
--------
R
---
F
---
G
I
E
Q
----
S
D
V
V
T
A
V
-
S
H
S
L
I
N
E
T
H
E
L
-
V
K
P
-------------
N
K
D
I
Q
T
--
V
Y
N
-
F
-
I
D
E
R
V
Y
F
K
-
R
-
D
--------
M
--
T
Q
L
K
K
E
Y
G
I
-
S
------------
K
I
L
I
H
------
I
S
-
N
-
F
R
---
K
V
K
R
V
Q
D
V
V
Q
---
A
F
----
A
K
I
---
V
T
E
------
V
D
----
A
K
L
L
L
V
-
G
D
G
---
P
-
E
------
F
C
T
I
L
Q
L
V
K
-
N
L
HI
E
--------
D
R
V
L
F
L
----
G
K
-------
Q
--
D
--
N
V
A
E
L
L
A
M
S
D
L
M
L
-----------
L
LSEK----------
E
-----
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
--
T
-
R
V
G
--
G
I
-----
P
E
V
I
Q
H
G
-
D
T
G
Y
L
--
C
E
V
------------------
G
--
D
---
T
T
G
V
A
D
Q
A
I
Q
L
L
K
--
D
--
E
E
L
H
R
N
M
G
E
R
A
R
E
S
V
Y
E
Q
F
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
L
R
-----------
78
Fugue
50.61
14%
5
- C2 -
3C48
3
MSHA_CORGL
A:
[19-438]
--
S
H
M
R
V
A
M
I
S
M
-
H
---------------
T
---
S
PLQ
Q
G
M
N
V
Y
I
L
S
T
A
T
E
L
A
K
Q
-
G
I
E
-
V
-------
D
I
Y
T
R
A
T
R
P
S
Q
G
E
I
V
R
V
A
E
N
L
R
-----------
V
I
N
I
A
A
G
P
Y
----------
E
G
L
S
K
E
E
L
P
T
Q
L
A
A
F
T
G
G
----
M
L
S
F
T
R
R
E
K
V
TY
D
L
I
H
S
H
Y
W
L
S
-
G
Q
V
-
G
--
W
--
L
L
R
D
L
-
W
R
I
P
L
I
H
T
A
---
H
TL
A
A
V
K
N
SYDT
P
E
S
--
E
A
R
R
----
I
----
C
-----------
E
--------
Q
---
Q
---
L
V
D
N
----
A
D
V
L
A
V
N
-
T
Q
E
E
M
Q
D
L
M
H
H
Y
D
A
D
-------------
P
D
R
I
S
V
--
V
S
P
-
G
-
A
D
V
E
L
Y
S
P
-
G
-
T
-----------
E
R
S
R
R
E
L
G
I
-
P
---------
L
H
T
K
V
V
A
F
V
GRLQP
F
K
G
P
-
Q
V
---
L
I
K
A
V
A
A
L
F
D
---
R
-----------
D
--------
P
D
----
R
N
L
R
V
I
I
C
G
G
---
P
S
D
------
T
Y
R
H
M
A
E
E
L
-
G
V
--
E
--------
K
R
I
R
F
L
----
D
P
-------
R
P
P
S
--
E
L
V
A
V
Y
R
A
A
D
I
V
A
-----------
V
PSFN----------
E
-----
S
F
G
L
V
A
M
E
A
Q
A
S
G
T
P
V
I
A
--
A
-
R
V
----
G
G
L
-
P
I
A
V
A
E
G
E
T
-
G
L
L
V
D
--
G
--------------------
H
--
S
---
P
H
A
W
A
D
A
L
A
T
L
L
D
--
D
--
D
E
T
R
I
R
M
G
E
D
A
V
E
H
A
-
R
T
F
S
W
A
A
T
A
A
Q
L
S
S
L
Y
N
D
A
I
A
N
E
N
V
D
G
E
T
HHG
85
Fugue
50.46
13%
22
- C2 -
3OKP
1
PIMB_CORGL
A:
[4-381]
---
S
R
K
T
L
V
V
T
N
-
D
---------------
F
PPR
I
---
G
G
I
Q
S
Y
L
R
D
F
I
A
T
Q
D
P
E
-
S
-
I
-
V
-------
V
F
A
S
T
Q
N
A
E
E
A
H
A
Y
D
K
T
L
D
Y
E
V
-----------
I
R
W
P
R
S
V
M
L
P
T
P
T
T
A
H
A
M
A
E
I
I
R
E
R
E
I
D
N
V
W
F
G
A
A
A
P
----
L
A
L
M
A
G
T
A
K
Q
-----
A
G
A
--
S
K
-
V
I
A
-
S
--
T
--
H
G
H
E
V
-
G
W
S
-
M
L
P
G
S
---
R
------------
Q
S
--
L
R
K
I
----
G
----
T
-----------
E
------------------------
V
D
V
L
T
Y
I
-
S
Q
Y
T
L
R
R
F
K
S
A
-
F
G
S
-------------
H
P
T
F
E
H
L
P
S
G
V
-
D
-
V
K
R
F
T
P
A
T
-
P
-
E
--------
D
--
K
S
A
T
R
K
K
L
G
-
F
---------
T
D
T
T
P
V
I
A
------
C
N
S
R
-
L
V
---
P
R
K
G
Q
D
S
L
I
K
A
M
P
Q
V
----
I
-
A
---
A
--------
R
P
----
D
A
Q
L
L
I
V
G
S
G
---
R
Y
-------
E
S
T
L
R
R
L
A
T
-
D
V
--
S
--------
Q
N
V
K
F
L
----
G
R
-------
L
E
Y
Q
--
D
M
I
N
T
L
A
A
A
D
I
F
A
M
P
A
R
T
R
GGGLD
V
--------------
E
-----
G
L
G
I
V
Y
L
E
A
Q
A
C
G
V
P
V
I
A
--
G
-
T
S
---
G
G
A
P
-
E
T
V
T
--
P
A
T
-
G
L
V
V
E
--
G
--------------------
S
--
D
---
V
D
K
L
S
E
L
L
I
E
L
L
D
--
D
--
P
I
R
R
A
A
M
G
A
A
G
R
A
H
V
-
E
A
E
W
S
---
W
E
I
M
G
E
R
L
T
N
I
L
Q
S
E
P
R
-------
68
HHSearch
50.31
14%
-6
- C2 -
2IUY
2
?
A:
[3-340]
---
P
L
K
V
A
L
V
N
I
-
P
LRVPGSDAWISVPPQ
G
---
Y
---
G
G
I
Q
W
V
V
A
N
L
M
D
G
L
L
E
L
-
G
H
--
E
-------
V
F
L
L
G
A
P
G
--
S
P
-
A
---
G
R
P
G
L
------------------
T
V
V
--------------------
P
A
G
E
P
E
E
----
I
E
R
W
L
R
T
A
D
V
--
D
V
V
H
D
H
--
S
G
-
G
V
I
-
G
-----
P
A
G
L
P
---
P
-
G
T
A
F
I
---
S
------------
S
H
--
H
F
T
T
----
R
----------------------------------
P
V
N
----
P
V
G
C
T
Y
S
-
S
R
A
Q
R
A
H
C
G
-----
G
-------------
G
D
D
A
P
V
--
I
P
I
-
P
-
V
D
P
A
R
Y
R
S
---
A
--------
A
---------
D
Q
-
V
---------
A
K
E
D
F
L
L
F
------
M
G
-
R
-
V
S
---
P
H
K
G
A
L
E
A
A
A
---
F
A
----
H
-
A
------------
C
G
----
R
R
L
V
L
A
-
G
P
A
---
W
E
-------
P
E
Y
F
D
E
I
T
R
-
R
Y
--
G
--------
S
T
V
E
P
I
----
G
E
-------
V
GG
E
--
R
R
L
D
L
L
A
S
A
H
A
V
L
-----------
A
MSQAVTGPWGGIWC
E
-----
P
G
A
T
V
V
S
E
A
A
V
S
G
T
P
V
V
G
--
T
-
G
N
G
--
C
L
-----
A
E
I
V
P
S
V
-
G
E
V
V
G
--
Y
--------------------
G
--
T
DFA
P
D
E
A
R
R
T
L
A
G
L
P
A
--
S
--
D
E
V
R
R
A
-------
A
V
-
R
L
W
G
H
V
T
I
A
E
R
Y
V
E
Q
Y
R
R
L
L
A
G
A
T
--------
61
HHSearch
48.34
14%
-4
- C2 -
4N9W
2
PIMA_MYCS2
A:
[4-372]
---
A
M
R
I
G
M
V
C
P
-
Y
SFD------------
V
---
P
---
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
-
G
H
--
E
-------
V
S
V
L
A
P
A
S
P
H
V
K
-
L
P
D
Y
V
V
S
G
G
-----------
K
----
A
V
P
I
P
---
Y
N
G
S
V
A
R
------
L
R
F
-
G
P
A
T
H
R
K
----
V
K
K
W
I
A
E
G
D
F
--
D
V
L
H
I
H
--
E
P
-
N
A
P
-
S
--
L
S
-
M
L
A
L
Q
-
A
-
A
-
E
G
P
I
V
---
A
------------
T
F
--
H
T
S
T
----
T
----
K
-----------
S
L
TLSVFQ-
G
---
I
L
R
P
Y
H
E
K
----
I
I
G
R
I
A
V
-
S
------------------------------
A
V
E
--
I
P
N
-
G
-
V
D
V
A
S
F
A
D
-
A
-
P
--------
L
-----
L
--
D
G
Y
-
P
---------
R
E
G
R
T
V
L
F
------
L
G
-
R
-
Y
D
E--
P
R
K
G
M
A
V
L
L
A
---
A
L
----
P
K
L
---
V
A
R
F
-----
P
D
----
V
E
I
L
I
V
-
G
R
G
---
D
E
--------
D
E
L
R
E
Q
A
G
-
D
L
--
A
--------
G
H
L
R
F
L
----
G
Q
-------
V
--
D
D
A
T
K
A
S
A
M
R
S
A
D
V
Y
C
-----------
A
PHLGG---------
E
-----
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
--
S
-
D
L
D
--
A
F
-----
R
R
V
L
A
D
G
-
D
A
G
R
L
--
V
P
V
------------------
D
--
D
---
A
D
G
M
A
A
A
L
I
G
I
L
E
--
D
--
D
Q
L
R
A
G
Y
V
A
R
A
S
E
R
V
-
H
R
Y
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
G
A
G
I
--------
67
HHSearch
46.61
17%
28
- C2 -
3OT5
2
?
A:
[104-397]
---------------------------------------------------------------------------------------------------------------------------------------
N
G
----
I
N
E
V
I
A
A
E
N
P
--
D
I
V
L
V
H
--
G
D
-
T
T
T
-
S
--
F
A
A
G
L
A
T
F
-
Y
-
Q
-
Q
K
M
L
G
---
H
------------
V
E
--
A
G
L
R
----
T
----
W
NKYSP
F
P
E
E
M
N
R
--------
Q
---
L
---
T
G
V
M
----
A
D
I
H
F
S
P
-
T
K
Q
A
K
E
N
L
L
A
E
-
G
K
D
-------------
P
A
T
I
F
V
--
T
G
N
-
T
A
I
D
A
L
K
T
T
V
-
Q
-
K
--------
D
Y
H
H
P
I
L
E
--
N
L
-----------
G
D
N
R
L
I
L
M
------
T
A
H
R
-
R
E
N
--
L
G
E
P
M
Q
G
M
F
E
---
A
V
----
R
E
I
---
V
E
S
R
-----
E
D
----
T
E
L
V
Y
P
M
H
L
N
---
P
A
V
------
R
E
K
A
M
A
I
L
--
G
G
--
H
--------
E
R
I
H
L
I
----
E
P
-------
L
--
D
A
I
D
F
H
N
F
L
R
K
S
Y
L
V
F
-----------
T
--------------------
D
S
G
G
V
Q
E
E
A
P
G
M
G
V
P
V
L
V
--
L
R
D
T
T
--
E
R
-----
P
E
G
I
E
A
G
-
T
L
K
L
I
--
G
--------------------
T
--
N
---
K
E
N
L
I
K
E
A
L
D
L
L
D
--
N
--
K
E
S
H
D
K
M
A
Q
A
A
N
P
Y
G
-
D
G
F
A
A
N
R
I
L
A
A
I
K
S
H
F
E
E
T
D
R
-----------
75
HHSearch
45.62
12%
-26
- C2 -
2XCI
7
KDTA_AQUAE
A:
[38-372]
--
N
C
K
G
A
L
W
V
H
--
T
---------------
A
---
S
---
I
G
E
F
N
T
F
L
P
I
L
K
E
L
K
R
--
E
H
--
R
-------
I
L
L
T
Y
F
S
P
R
A
R
E
---
Y
L
K
T
-
K
S
-----------
D
---
F
Y
D
C
L
H
----
P
-
L
-------------
P
L
D
N
P
F
S
----
V
K
R
F
E
E
L
S
K
P
--
K
A
L
I
V
V
--
E
R
-
E
F
W
-
P
--
S
--
L
I
I
-
F
-
T
---
K
V
P
K
I
---
L
------------
V
N
--
A
Y
A
K
----
G
----
S
L
I
---------
E
--------
K
---
I
---
L
S
K
K
----
F
D
L
I
I
M
R
-
T
Q
E
D
V
E
K
F
K
T
F
-
G
A
K
---------------
R
V
F
S
--
C
G
N
-
L
-
K
F
I
C
Q
K
G
K
--------------------
G
--
I
-
K
---------
L
K
G
E
-
F
I
V
------
A
G
S
--
I
H
----
T
G
E
V
E
I
I
L
K
---
A
F
----
K
E
I
---
K
K
T
Y
-----
S
S
----
L
K
L
I
L
V
-
P
R
H
---
I
E
N
------
A
K
I
F
E
K
K
A
R
-
D
F
GF
K
TSFFENLE
G
D
V
I
L
V
----
D
R
-------
F
--
G
--
I
L
K
E
L
Y
P
V
G
K
I
A
I
-----------
V
--------------
G
GTFVN
I
G
G
H
N
L
L
E
P
T
C
W
G
I
P
V
I
Y
--
G
-
P
Y
T
H
-
K
V
-----
N
D
L
K
E
F
L
E
K
E
G
A
G
--
F
E
V
------------------
K
--
N
---
E
T
E
L
V
T
K
L
T
E
L
L
S
--
V
--
K
K
-
E
I
K
V
E
E
K
S
R
E
I
K
-
G
-----
C
Y
L
E
K
L
R
E
F
L
R
---------------