@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22050: (2016-07-04 )
MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFKNGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYEKVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKAYPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLAPKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSFHDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQNGHKKEAERGLIGALGPGFSSELLLFSWEKGA
Atome Classification :
(20 SA)
.........10........20..-......30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.....-.-.220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
F
I
L
SIGTSLPAYNV
N
Q
E
K
A
A
E
-
F
A
R
Y
M
F
Q
H
S
F
K
D
I
D
R
L
L
S
S
FKNGQIH
S
R
QF
V
K
P
I
E
W
Y
K
EGHSFEEK
N
Q
I
Y
I
E
E
T
L
K
H
S
R
A
A
V
R
E
C
LSH
P
E
F
F
Q
EAI
P
Y
E
K
V
E
A
V
F
F
V
SSTGLSTP
S
I
E
A
R
L
M
N
ELPFSPYTKRIP
I
W
G
LGCAG
G
A
S
G
L
A
R
A
A
E
Y
C
K
AYP
E
A
F
V
L
V
I
S
A
E
L
C
S
L
T
FQPEDKTKSNLIGT
S
L
FG
D
G
I
A
A
A
L
LCG
E
K
A
D
R
R
V
S
K
L
KL-A-
P
K
I
M
D
A
Q
S
V
L
M
KQSEDVMGWDFTDQ
G
F
K
V
I
FSRD
I
P
T
L
V
E
K
W
L
KTN
V
Q
I
F
L
DKHKL
S
F
H
D
I
S
V
F
L
AHPGG
K
K
V
I
D
A
Y
I
K
SLGL
S
S
E
K
L
S
S
A
Q
S
I
L
Q
KHGNMSS
A
T
I
L
Y
V
I
K
D
H
L
QNG
H
K
K
E
A
ERG
L
I
GALGPGFSS
E
L
L
L
F
SWEKGA
38
HHSearch
92.24
33%
-115
* C2 *
4JAQ
1
PKS11_MYCTU
D:
[2-352]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
-
S
F
V
E
F
P
-
G
L
K
E
H
E
E
I
I
R
R
L
H
A
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
-----
L
R
P
S
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
D
R
R
A
E
Q
--
V
R
A
G
-
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
----
41
HHSearch
90.37
30%
-120
- C2 -
1U0M
2
RPPA_STRCO
A:
[10-357]
-
A
T
L
C
R
P
S
V
S
V
P
E
H
V
I
T
M
E
E
T
L
E
-
L
A
R
R
R
H
T
D
H
-
P
Q
L
P
L
A
L
R
L
I
E
N
T
G
V
R
T
R
H
I
V
Q
P
I
E
D
T
L
E
H
P
G
F
E
D
R
N
K
V
Y
E
R
E
A
K
S
R
V
P
A
V
I
Q
R
A
L
D
D
A
E
-----
L
L
A
T
D
I
D
V
I
I
Y
V
S
C
T
G
F
M
M
P
S
L
T
A
W
L
I
N
E
M
G
F
D
S
T
T
R
Q
I
P
I
A
Q
L
G
C
A
A
G
G
A
A
I
N
R
A
H
D
F
C
T
A
Y
P
E
A
N
A
L
I
V
A
C
E
F
C
S
L
C
Y
Q
P
T
D
L
G
V
G
S
L
L
C
N
G
L
F
G
D
G
I
A
A
A
V
V
R
G
R
G
G
--------
T
-
G
-
V
R
L
E
R
N
G
S
Y
L
I
P
K
T
E
D
W
I
M
Y
D
V
K
A
T
G
F
H
F
L
L
D
K
R
V
P
A
-
T
M
E
P
L
A
P
A
L
K
E
L
A
G
E
H
G
W
D
A
S
D
L
D
F
Y
I
V
H
A
G
G
P
R
I
L
D
D
L
S
T
F
L
E
V
D
P
H
A
F
R
F
S
R
A
T
L
T
E
Y
G
N
I
A
S
A
V
V
L
D
A
L
R
R
L
F
D
E
G
G
V
E
E
G
A
R
G
L
L
A
G
F
G
P
G
I
T
A
E
M
S
L
G
C
W
Q
T
A
-
21
PsiBlast_CBE
84.70
33%
-27
- C2 -
4JAQ
2
PKS11_MYCTU
C:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
29
PsiBlast_CBE
84.61
33%
-26
- C2 -
4JAO
1
PKS11_MYCTU
A:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
22
PsiBlast_CBE
84.38
33%
-26
- C2 -
4JAQ
2
PKS11_MYCTU
B:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
27
PsiBlast_CBE
84.14
33%
-24
- C2 -
4JAO
1
PKS11_MYCTU
C:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
34
PsiBlast_CBE
84.09
33%
-22
- C2 -
4JAT
1
PKS11_MYCTU
C:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
S
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
-
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
23
PsiBlast_CBE
83.95
33%
-25
- C2 -
4JAQ
1
PKS11_MYCTU
A:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
26
PsiBlast_CBE
83.86
33%
-23
- C2 -
4JAP
1
PKS11_MYCTU
A:
[1-353]
M
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
2
PsiBlast_PDB
83.86
33%
-23
- C2 -
4JAP
1
PKS11_MYCTU
D:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
6
PsiBlast_PDB
83.24
33%
-21
- C2 -
4JD3
1
PKS11_MYCTU
A:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
S
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
-
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
35
PsiBlast_CBE
83.22
33%
-21
- C2 -
4JAT
1
PKS11_MYCTU
B:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
S
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
-
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
24
PsiBlast_CBE
83.15
33%
-24
- C2 -
4JAP
2
PKS11_MYCTU
C:
[1-353]
M
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
28
PsiBlast_CBE
83.02
33%
-25
- C2 -
4JAO
1
PKS11_MYCTU
B:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
25
PsiBlast_CBE
82.89
33%
-21
- C2 -
4JAP
2
PKS11_MYCTU
B:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
31
PsiBlast_CBE
82.86
33%
-20
- C2 -
4JD3
2
PKS11_MYCTU
C:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
S
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
-
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
1
PsiBlast_PDB
82.78
33%
-26
- C2 -
4JAO
1
PKS11_MYCTU
D:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
4
PsiBlast_PDB
82.62
33%
-21
- C2 -
4JAR
-
PKS11_MYCTU
A:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
3
PsiBlast_PDB
82.62
33%
-24
- C2 -
4JAQ
1
PKS11_MYCTU
D:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
C
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
G
G
-
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---
32
PsiBlast_CBE
82.45
33%
-20
- C2 -
4JD3
3
PKS11_MYCTU
B:
[2-353]
-
S
V
I
A
G
V
F
G
A
L
P
P
H
R
Y
S
Q
S
E
I
T
D
S
F
V
E
F
P
G
L
K
E
H
E
E
I
I
R
R
L
H
A
--
A
A
K
V
N
G
R
H
L
V
L
P
L
Q
Q
Y
P
S
L
T
D
F
G
D
A
N
E
I
F
I
E
K
A
V
D
L
G
V
E
A
L
L
G
A
L
D
D
A
N
L
R
P
S
-----
D
I
D
M
I
A
T
A
T
V
T
G
V
A
V
P
S
L
D
A
R
I
A
G
R
L
G
L
R
P
D
V
R
R
M
P
L
F
G
L
G
S
V
A
G
A
A
G
V
A
R
L
R
D
Y
L
R
G
A
P
D
D
V
A
V
L
V
S
V
E
L
C
S
L
T
Y
P
A
V
K
P
T
V
S
S
L
V
G
T
A
L
F
G
D
G
A
A
A
V
V
A
V
G
---
D
R
R
A
E
Q
V
R
A
-
G
G
P
D
I
L
D
S
R
S
S
L
Y
P
D
S
L
H
I
M
G
W
D
V
G
S
H
G
L
R
L
R
L
S
P
D
L
T
N
L
I
E
R
Y
L
A
N
D
V
T
T
F
L
D
A
H
R
L
T
K
D
D
I
G
A
W
V
S
H
P
G
G
P
K
V
I
D
A
V
A
T
S
L
A
L
P
P
E
A
L
E
L
T
W
R
S
L
G
E
I
G
N
L
S
S
A
S
I
L
H
I
L
R
D
T
I
E
K
-
R
P
P
S
G
S
A
G
L
M
L
A
M
G
P
G
F
C
T
E
L
V
L
L
R
W
R
---