@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22120: (2016-07-04 )
MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNIKKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMVCNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLKLDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNGLVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQDIGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVIMRKSL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.-.-.....150.......-160.......170......-.180.......190---........200.......-210......-.--220..-.....230....--------...240--.......--250.......260.......270.......280.......290.......300.......310.......320.......330.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKKTTGH
T
T
I
K
D
V
A
E
C
AGV
S
K
S
T
V
S
R
Y
INGKIDAI
S
P
E
K
V
K
N
I
K
K
A
I
A
ELNY
R
P
S
K
M
AQGLKIKKS
K
L
I
G
F
V
V
ADITNP
F
S
V
A
A
F
R
G
V
E
E
V
C
D
QYG
Y
S
I
M
V
CNTDNS
P
E
K
E
R
E
M
L
L
K
L
EAHSV
E
G
L
I
L
NATGE
N
K
D
V
L
R
A
F
A
-
E
-QQI
P
T
I
L
I
DRKLPD
L
-
K
L
D
T
VTTDN
R
W
I
T
K
E
I
L
Q
K
-
V
Y
SKGY
T
D
V
A
L
FT----EP
I
S
SISP
R
A
E
R
A
A
V
Y
Q
E
-
M
A
S
V
QNVN
G
-
L
--
V
R
L
H
E-IDVK
D
K
E
Q
L
K
A
E
--------
L
R
S
F
H
K
--EM
P
E
Q
K
K
--
A
I
L
A
LN
G
L
I
M
L
K
I
I
S
C
M
E
E
LGLRI
P
Q
DIGIAGFDDT
E
W
Y
K
LIGPG
I
T
TIAQP
S
H
DM
G
R
T
A
M
E
R
V
L
K
R
IEGDKGAP
Q
T
I
E
L
E
A
K
V
I
M
RKSL
2
PsiBlast_PDB
82.73
28%
-63
- C1 -
3OQM
4
CCPA_BACSU
A:
[4-330]
---------
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
-
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
G
N
I
T
D
E
H
V
A
E
F
K
-
R
-
S
P
V
P
I
V
L
A
A
S
V
E
E
Q
E
-
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
-
L
V
D
K
G
H
T
D
I
A
F
V
S
----
G
P
M
A
E
P
I
N
R
S
K
K
L
Q
G
Y
K
R
-
A
--------------
L
E
E
-
A
N
L
P
F
N
E
Q
F
V
A
E
G
DYT
Y
D
S
G
L
E
A
L
Q
H
--
L
M
S
L
D
K
K
PT
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
-
3
PsiBlast_PDB
82.13
28%
-66
- C1 -
3OQN
2
CCPA_BACSU
A:
[4-330]
---------
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
-
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
G
N
I
T
D
E
H
V
A
E
F
K
-
R
-
S
P
V
P
I
V
L
A
A
S
V
E
E
Q
E
-
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
-
L
V
D
K
G
H
T
D
I
A
F
V
S
----
G
P
M
A
E
P
I
N
R
S
K
K
L
Q
G
Y
K
R
-
A
--------------
L
E
E
-
A
N
L
P
F
N
E
Q
F
V
A
E
G
DYT
Y
D
S
G
L
E
A
L
Q
H
--
L
M
S
L
D
K
K
PT
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
-
1
PsiBlast_PDB
81.24
28%
-65
- C1 -
3OQO
4
CCPA_BACSU
A:
[4-330]
---------
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
-
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
G
N
I
T
D
E
H
V
A
E
F
K
-
R
-
S
P
V
P
I
V
L
A
A
S
V
E
E
Q
E
-
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
-
L
V
D
K
G
H
T
D
I
A
F
V
S
----
G
P
M
A
E
P
I
N
R
S
K
K
L
Q
G
Y
K
R
-
A
--------------
L
E
E
-
A
N
L
P
F
N
E
Q
F
V
A
E
G
DYT
Y
D
S
G
L
E
A
L
Q
H
--
L
M
S
L
D
K
K
PT
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
-
4
PsiBlast_PDB
76.34
26%
-40
- C1 -
1ZVV
4
CCPA_BACSU
A:
[2-330]
-------
N
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
-
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
S
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
Q
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
M
S
G
N
V
T
E
E
H
V
E
E
L
K
-
K
-
S
P
V
P
V
V
L
A
A
S
I
E
S
T
N
-
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
-
L
I
D
S
G
H
K
N
I
A
F
V
S
G
TLE
E
P
I
N
----
H
A
K
K
V
K
G
Y
K
R
-
A
L
T
---
E
S
G
-
L
--
P
V
R
D
S
-
Y
I
V
E
G
D
Y
T
Y
D
S
G
--------
I
E
A
V
E
K
--
L
L
E
E
D
E
K
PT
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
E
T
V
D
S
S
I
V
E
L
P
H
R
I
E
F
R
Q
S
-
19
PsiBlast_PDB
75.44
26%
-23
- C1 -
1QPZ
2
PURR_ECOLI
A:
[1-330]
--------
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
7
PsiBlast_PDB
74.92
26%
-24
- C1 -
2PUA
2
PURR_ECOLI
A:
[1-330]
--------
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
9
PsiBlast_PDB
74.69
26%
-22
- C1 -
2PUC
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
6
PsiBlast_PDB
74.48
26%
-17
- C1 -
1JH9
4
PURR_ECOLI
A:
[1-330]
--------
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
R
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
18
PsiBlast_PDB
74.43
26%
-24
- C1 -
1QP4
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
17
PsiBlast_PDB
74.37
26%
-22
- C1 -
1QP0
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
16
PsiBlast_PDB
74.33
26%
-24
- C1 -
1WET
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
11
PsiBlast_PDB
74.14
26%
-23
- C1 -
2PUE
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
Q
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
12
PsiBlast_PDB
74.06
26%
-21
- C1 -
2PUF
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
Q
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
8
PsiBlast_PDB
74.03
26%
-19
- C1 -
2PUB
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
53
HHSearch
73.87
26%
-21
- C1 -
1QPZ
2
PURR_ECOLI
A:
[1-330]
--------
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
-
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
-
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
-
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
R
N
T
G
-
A
G
R
L
A
G
F
M
K
A
M
E
E
A
-
M
I
K
V
P
E
SW
I
V
Q
G
D
-
F
E
P
E
S
G
Y
R
A
-----------
M
Q
Q
I
L
S
--
Q
-
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
10
PsiBlast_PDB
73.66
26%
-23
- C1 -
2PUD
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
A
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
14
PsiBlast_PDB
73.26
26%
-19
- C1 -
1PNR
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
15
PsiBlast_PDB
73.21
26%
-19
- C1 -
1BDI
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
13
PsiBlast_PDB
73.21
26%
-22
- C1 -
2PUG
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
Q
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
20
PsiBlast_PDB
72.94
26%
-20
- C1 -
1ZAY
2
PURR_ECOLI
A:
[2-330]
---------
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
-
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
----
G
P
L
E
R
N
T
G
A
G
R
L
A
G
F
M
K
A
-
M
E
E
-----
A
-
M
--
I
K
V
P
E
S
W
I
V
Q
G
D
F
E
P
E
S
G
--------
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
--
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V