@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22400: (2016-07-04 )
MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKYINPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKYELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTGLIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFSVREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFANREHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLFPFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNLPSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHKKRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQRNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKSWSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYCQTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSATLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQDTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKLMKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKGKNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSVSEMTDSELEAYVAGEKE
Atome Classification :
(21 SA)
-------.........10....----...-----.20........30..---.-------------.----..-.--.40......--..--50-.........60....-----.-----.-..70.--.-.......80...---------.----...-------.90.-.-.....-.100.......110-.---------.----.----..----....120---...-..---..----------130....-...140...---..---.--..----150.......160.......170-.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360-.......370.......380......-------.390-....-------...400.......410.......420.......430.......440.......450---....-----....------.460.......470.......480.......490...-....500.......510.......520.......530.......540.......550.......560.......570....-...580.......590..-.....600.......610..-.....620.....-..630.......640.......650.......660.......670.......680.......690.......700.......710....--...720.......730--------........740.......750.......760.......770.......780.......790.......800.......810-..---......820....---...830.......840.......850...--....860........870.......880.......890.......900.......910.......920.......930
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MNK
Q
R
F
V
V
I
D
V
ETTG----NSP-----KKG
D
K
I
I
Q
I
A
A
V
V
IE---N-------------
G
----
Q
I
-
T
--
E
R
F
S
K
YINP--NK--
S
--
I
P
A
F
I
E
Q
L
T
G
I
S
N
QM-----V-----E-NEQ-
P
--
F
-
E
A
V
A
E
E
V
F
Q
LLD---------G----
A
Y
F
-------
V
A
H
N
-
I
-
H
F
D
L
G
-
F
V
K
Y
E
L
H
KAGFQ---L---------P----D----
C
E
----
V
L
D
T
V
E
L
---
S
R
I
-VF---PG----------FEGY
K
L
T
-
E
L
S
E
-
E
L
Q
L
---RH---D--QP----HRADSDA
E
V
T
G
L
I
F
L
E
I
L
E
K
L
R
Q-LP
Y
P
T
L
K
Q
L
R
R
L
S
Q
H
F
I
S
D
L
T
H
L
L
D
M
F
INENRHTEIPGYTRFSSFSVREP
E
A
I
D
V
R
INEDE
N
F
S
F
E
I
ESWEAG
N
E
K
A
L
S
E
L
MPGYEKRDG
Q
M
M
M
M
R
E
V
A
D
A
FANR
E
H
A
L
I
EAPPGI
G
K
T
I
G
Y
L
I
P
A
A
L
F
AKKSKK
P
V
I
I
S
T
Y
S
T
L
L
Q
Q
Q
I
L
TKDL
P
I
V
Q
DLFPF
P
V
T
A
A
I
LKGQS
H
Y
L
C
L
Y
K
F
E
Q
V
LHEE-DD
N
Y
D
A
V
L
T
K
A
Q
L
L
V
W
L
T
ETNTG
D
V
A
-------
E
L
NL-PSG
G
-------
K
L
L
W
D
RLAYDD
D
S
YKRSRSE
H
V
I
G
F
Y
E
R
A
K
Q
I
A
MRS
D
L
V
I
TN
H
S
L
L
LTDEGSHK-----KRLP-----ESG
T
------
F
I
I
DE
A
H
H
F
E
R
A
A
S
E
HLGKR
A
T
Y
I
E
L
H
T
K
L
S
R
IG
T
L
K
-
E
Q
G
L
L
K
K
M
R
Q
L
F
Q
RNSLP
V
D
S
F
F
E
L
E
E
W
L
Q
H
VQAE
S
D
A
F
F
S
S
V
H
S
F
V
K
RRK
P
K
E
D
L
N
R
L
V
F
KVNKESQDKSW
S
I
L
T
D
G
A
E
R
-
L
C
S
M
L
T
H
L
Q
Q
L
F
E
A
Q
S
S
L
-
M
E
K
H
L
K
GMKS
K
T
V
F
L
A
D
E
Y
Q
-
R
S
M
K
G
L
Q
H
Y
C
Q
T
L
-
Q
K
LFFGSDDD
E
A
V
W
I
E
I
DAKGAK
N
A
V
A
I
Y
AQPLE
P
G
E
L
L
A
D
Q
F
FARKN
S
V
V
L
T
S
A
T
L
T
VE
G
S
F
Q
F
M
I
E
RL
G
L
S
DFFPR
T
M
RIESPF
S
Y
D
--
E
R
M
Q
VMI
P
K
E
M
K
S
I
Q---------DTGQ
P
E
F
I
Q
D
T
A
R
Y
I
E
L
M
A
KEKQP
K
I
L
V
L
FTS
H
D
M
L
K
K
V
H
Q
E
L
K
HNM
S
A
S
G
I
Q
L
L
A
Q
GITGGSP
G
K
L
M
K
TFKTSN
Q
A
I
L
-L-GT---NHFWEGVDFPGDE---
L
T
T
V
M
I
V
R
LPFRSPDHP
L
H
A
A
K
C
E
L
A
R
KK--GKNPF-QTVS
L
P
E
A
V
L
T
F
R
Q
G
I
G
R
L
L
R
SAGDK
G
T
I
I
I
LDRRIKTAGY
G
R
L
F
L
DALPTT
S
V
S
E
M
T
D
S
E
L
E
A
Y
VAGEKE-
2
PsiBlast_PDB
65.88
22%
27
- C1 -
4A15
6
XPD_THEAC
A:
[5-599]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Y
Q
V
E
A
I
D
F
L
R
S
S
L
Q
K
S
Y
G
V
A
L
E
S
P
T
G
S
G
K
T
I
M
A
L
K
S
A
L
Q
Y
S
S
E
R
K
L
K
V
L
Y
L
V
R
T
N
S
Q
E
E
Q
V
I
K
E
L
R
S
L
S
S
T
M
---
K
I
R
A
I
P
M
Q
G
R
V
N
M
C
I
L
Y
R
M
V
D
D
L
H
E
I
-
N
A
E
S
L
A
K
F
C
N
M
K
K
----
R
E
V
M
A
G
N
E
A
ACPYFNF
K
I
R
S
-
D
E
T
K
-------
R
F
L
F
D
E
L
P
T
A
E
E
F
Y
D
Y
G
E
R
N
N
V
C
P
-
Y
E
S
M
K
A
A
L
P
D
A
D
I
V
I
A
P
Y
A
Y
F
L
-
N
R
S
V
A
E
-----
K
F
L
S
-----
H
W
G
V
SRNQ
I
V
I
I
L
D
E
A
H
N
L
P
-----
D
I
G
R
S
------------
I
G
S
F
R
I
S
V
E
S
L
N
R
A
D
R
E
A
Q
A
Y
G
D
P
-----
E
L
S
Q
K
I
-
H
V
S
D
L
I
E
M
I
R
S
A
L
Q
S
M
V
S
E
R
C
G
K
G
D
V
-
R
I
R
F
Q
E
F
M
E
Y
----
M
R
I
M
N
K
R
S
E
R
E
I
R
S
L
L
N
Y
L
Y
L
F
G
E
-------------------
Y
V
E
N
E
K
E
-
K
V
G
K
V
P
F
S
Y
C
S
S
V
A
S
R
I
I
A
F
S
D
Q
D
E
E
K
Y
A
A
I
L
S
--
P
E
D
G
G
Y
M
Q
A
A
C
L
D
P
S
G
I
L
---------
E
V
L
K
E
S
K
T
I
H
M
S
G
T
-------
L
D
P
F
D
F
Y
S
D
I
T
G
F
E
I
P
F
-----
K
K
I
G
E
I
F
P
P
E
N
R
Y
I
A
Y
Y
DGV-------
D
E
K
E
L
D
R
M
A
T
V
I
E
D
I
I
L
K
V
K
K
N
T
I
V
Y
F
P
S
Y
S
L
M
D
R
V
E
N
R
V
S
F
E
H
M
K
E
-----
Y
R
G
I
D
Q
K
E
L
Y
S
M
L
K
K
F
R
R
D
H
G
T
I
F
A
V
-
S
G
---
G
R
L
--------
N
E
---
L
E
M
I
I
L
A
G
L
P
F
P
R
P
D
A
I
N
R
S
L
F
D
Y
Y
E
R
K
Y
--
G
K
G
W
E
-
Y
S
V
V
Y
P
T
A
I
-
K
I
R
Q
E
I
G
R
L
I
R
S
A
E
D
T
G
A
C
V
I
L
D
K
R
---
A
G
Q
F
R
K
F
I
P
D
M
K
K
T
S
-------------------
23
HHSearch
61.42
20%
6
- C1 -
4A15
6
XPD_THEAC
A:
[5-608]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
Y
Q
V
E
A
I
D
F
L
R
S
S
L
Q
K
S
Y
G
V
A
L
E
S
P
T
G
S
G
K
T
I
M
A
L
K
S
A
L
Q
Y
S
S
E
R
K
L
K
V
L
Y
L
V
R
T
N
S
Q
E
E
Q
V
I
-
K
E
L
R
S
L
S
S
T
--
M
K
I
R
A
I
P
M
Q
G
R
V
N
M
C
I
L
Y
R
M
V
D
D
L
H
E
I
---
N
A
E
S
L
A
K
F
C
N
M
K
--
K
R
E
V
M
A
G
N
E
A
-------
A
C
P
Y
-
F
N
F
K
IRS
D
E
T
K
R
F
L
F
D
E
L
P
-
T
A
E
E
F
Y
D
Y
G
E
R
N
N
V
C
P
Y
E
S
M
K
A
A
L
P
D
A
D
I
V
I
A
P
Y
A
Y
F
L
N
R
S
V
A
E
K
F
L
S
H
W
G
V
S
R
-----
N
Q
I
V
------
I
I
L
D
E
A
H
N
L
P
D
I
G
R
S
I
G
S
F
R
I
S
V
E
S
L
N
R
A
D
R
E
A
Q
A
Y
G
-
D
P
E
L
S
Q
K
I
-----
H
-------
V
S
D
L
I
E
M
---
I
R
S
A
L
Q
S
M
V
S
E
---
R
C
-------
G
K
G
D
V
R
I
R
F
Q
E
F
M
--
E
Y
M
R
I
M
---
N
K
R
-
S
E
R
E
I
R
S
L
L
N
Y
L
Y
L
F
G
E
Y
-
V
E
N
--------
E
K
--
E
-
K
V
G
K
V
P
F
S
Y
C
S
S
V
A
S
R
I
-
I
A
F
S
D
Q
D
E
E
K
Y
A
A
I
L
S
P
E
D
-----
G
G
Y
M
Q
A
A
C
L
D
P
S
G
I
L
E
-
V
-
L
K
-
E
S
K
T
I
H
M
S
G
T
L
D
P
---
F
D
F
Y
S
D
I
T
G
F
E
I
P
---
F
K
K
I
G
E
I
F
P
P
E
--
N
R
Y
I
A
Y
Y
D
-
G
V
----------------
D
E
K
E
L
D
R
M
A
T
V
I
E
D
I
I
L
K
V
K
K
N
T
I
V
Y
F
P
S
Y
S
L
M
D
R
V
E
N
R
V
S
F
E
H
-----
M
K
E
Y
R
G
I
D
Q
K
E
L
Y
S
M
L
K
K
F
R
R
D
H
G
T
I
F
-
A
-
V
S
G--
G
R
L
--------
N
E
---
L
E
M
I
I
L
A
G
L
P
F
P
R
P
-
D
A
I
N
R
S
L
F
D
Y
Y
E
R
K
--
Y
G
K
G
W
E
Y
S
V
V
Y
P
T
-
A
I
K
I
R
Q
E
I
G
R
L
I
R
S
A
E
D
T
G
A
C
V
I
L
D
K
R
A
G
------
Q
F
R
K
F
I
P
D
M
K
K
T
S
D
P
A
S
D
I
Y
N
F
-------
1
PsiBlast_PDB
54.90
34%
-143
- C2 -
2P1J
-
DPO3_THEMA
A:
[358-520]
------------
F
V
V
L
D
F
E
T
T
G
----
L
D
P
-----
Q
V
-
D
E
I
I
E
I
G
A
V
K
I
Q
---
G
-------------
G
----
Q
I
-
V
--
D
E
Y
H
T
L
I
K
P
--
S
R
--
E
--
I
S
R
K
S
S
E
I
T
G
I
T
Q
E
M
-----
L
-----
E
-
N
K
R
-
S
--
I
-
E
E
V
L
P
E
F
L
G
F
L
E
---------
D
----
S
I
I
-------
V
A
H
N
-
A
-
N
F
D
Y
R
-
F
L
R
L
W
I
K
K
V
M
G
L
---
D
---------
W
----
E
----
R
P
----
Y
I
D
T
L
A
L
---
A
K
S
-
L
----
L
K
----------
L
R
S
Y
S
L
D
-
S
V
V
E
-
K
L
G
L
---
G
P
---
F
--
R
H
----
H
R
A
L
D
D
A
R
V
T
A
Q
V
F
L
R
F
V
E
M
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
54.52
35%
-141
- C2 -
2P1J
-
DPO3_THEMA
A:
[357-520]
-----------
T
F
V
V
L
D
F
E
T
T
G
----
L
D
P
-----
Q
V
-
D
E
I
I
E
I
G
A
V
K
I
Q
---
G
-------------
G
----
Q
I
-
V
--
D
E
Y
H
T
L
I
K
P
--
S
R
--
E
--
I
S
R
K
S
S
E
I
T
G
I
T
Q
E
M
-----
L
-----
E
-
N
K
R
-
S
--
I
-
E
E
V
L
P
E
F
L
G
F
L
E
---------
D
----
S
I
I
-------
V
A
H
N
-
A
-
N
F
D
Y
R
-
F
L
R
L
W
I
K
K
V
M
G
L
---
D
---------
W
----
E
----
R
P
----
Y
I
D
T
L
A
L
---
A
K
S
-
L
L
---
K
-----------
L
R
S
Y
S
L
D
-
S
V
V
E
-
K
L
G
L
---
G
P
---
F
--
R
H
----
H
R
A
L
D
D
A
R
V
T
A
Q
V
F
L
R
F
V
E
M
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
52.56
22%
36
- C1 -
2VSF
2
XPD_THEAC
A:
[9-581]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
S
P
T
G
S
G
K
T
I
M
A
L
K
S
A
L
Q
Y
S
S
E
R
K
L
K
V
L
Y
L
V
R
T
N
S
Q
E
E
Q
V
I
K
E
L
R
S
L
S
S
T
M
---
K
I
R
A
I
P
M
Q
G
R
V
N
M
C
I
L
Y
R
M
V
D
D
L
H
E
I
-
N
A
E
S
L
A
K
F
C
N
M
K
K
----
R
E
V
M
A
G
N
E
A
ACPYFNF
K
I
R
S
-
D
E
T
K
-------
R
F
L
F
D
E
L
P
T
A
E
E
F
Y
D
Y
G
E
R
N
N
V
C
P
-
Y
E
S
M
K
A
A
L
P
D
A
D
I
V
I
A
P
Y
A
Y
F
L
-
N
R
S
V
A
E
-----
K
F
L
S
-----
H
W
G
V
SRNQ
I
V
I
I
L
D
E
A
H
N
L
P
-----
D
I
G
R
S
------------
I
G
S
F
R
I
S
V
E
S
L
N
R
A
D
R
E
A
Q
A
Y
G
D
P
-----
E
L
S
Q
K
I
-
H
V
S
D
L
I
E
M
I
R
S
A
L
Q
S
M
V
S
E
R
C
G
K
G
D
V
-
R
I
R
F
Q
E
F
M
E
Y
M
----
R
I
M
N
K
R
S
E
R
E
I
R
S
L
L
N
Y
L
Y
L
F
G
E
-------------------
Y
V
E
N
E
K
E
-
K
V
G
K
V
P
F
S
Y
C
S
S
V
A
S
R
I
I
A
F
S
D
Q
D
E
E
K
Y
A
A
I
L
S
--
P
E
D
G
G
Y
M
Q
A
A
C
L
D
P
S
G
I
L
---------
E
V
L
K
E
S
K
T
I
H
M
S
G
T
-------
L
D
P
F
D
F
Y
S
D
I
T
G
F
E
I
P
F
-----
K
K
I
G
E
I
F
P
P
E
N
R
Y
I
A
Y
Y
D
GVSSKY
D
T
L
D
E
K
E
L
D
R
M
A
T
V
I
E
D
I
I
L
K
V
K
K
N
T
I
V
Y
F
P
S
Y
S
L
M
D
R
V
E
N
R
V
S
F
E
H
M
K
E
-----
Y
R
G
I
D
Q
K
E
L
Y
S
M
L
K
K
F
R
R
D
H
G
T
I
F
A
V
-
S
G
---
G
R
L
S
E
-----
G
N
E
---
L
E
M
I
I
L
A
G
L
P
F
P
R
P
D
A
I
N
R
S
L
F
D
Y
Y
E
R
K
Y
--
G
K
G
W
E
-
Y
S
V
V
Y
P
T
A
I
-
K
I
R
Q
E
I
G
R
L
I
R
S
A
E
D
T
G
A
C
V
I
L
D
K
R
---
A
G
Q
F
R
K
F
I
P
D
M
K
K
T
S
-------------------
24
HHSearch
51.06
17%
-15
- C1 -
3CRV
10
XPD_SULAC
A:
[2-548]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
R
D
W
Q
E
K
L
K
D
K
V
I
E
G
L
R
N
N
F
L
V
A
L
N
A
P
T
G
S
G
K
T
L
F
S
L
L
V
S
L
E
----
V
K
P
K
V
L
F
V
V
R
T
H
N
E
F
Y
P
I
Y
-
R
D
L
T
K
I
R
E
K
--
R
N
I
T
F
S
F
L
V
G
K
P
S
S
C
L
Y
A
E
K
G
-
A
E
S
E
D
---------
I
P
C
K
Y
C
E
L
K
G
S
-----
I
V
-------
E
V
K
T
----
D
-------
D
S
P
L
S
L
V
----
K
K
L
K
K
D
G
L
Q
D
K
F
C
P
Y
Y
S
L
L
N
S
L
Y
K
A
D
V
I
A
L
T
Y
P
Y
F
F
I
D
R
Y
R
E
F
I----
D
I
D
L
-----
R
E
Y
M
------
I
V
I
D
E
A
H
N
L
D
K
V
-
N
E
L
E
E
R
S
L
S
E
I
T
I
Q
M
A
I
K
Q
S
K
S
E
E
-
S
R
R
I
-----------------
L
S
K
L
L
N
-------
Q
L
R
E
V
V
L
P
D
E
K
Y
I
----------
K
----
V
E
--
N
V
P
K
L
S
K
E
------
E
-
L
----
E
I
L
A
D
D
Y
E
D
I
R
K
D
S
L
K
Q
---------
G
--
K
-
V
N
K
-
I
H
I
G
S
I
---
L
R
F
F
-
S
L
L
-
S
--
I
G
---
S
F
I
P
F
S
-----
Y
S
K
R
L
V
I
K
N
P
E
I
S
Y
Y
L
N
L
-
L
N
D
N
E
L
S
I
I
L
M
S
G
T
L
P
P
---
R
E
Y
M
E
K
V
W
G
I
K
R
N
-
M
L
Y
L
D
V
E
R
E
I
Q
K
R
V
S
G
S
Y
E
C
Y
I
G
V
D
V
T
S
K
Y
---------
D
M
R
S
D
N
M
W
K
R
Y
A
D
Y
L
L
K
I
Y
F
Q
A
K
A
N
V
L
V
V
F
P
S
Y
E
I
M
D
R
V
M
S
R
I
S
L
-------
P
K
Y
V
E
S
E
D
S
S
-
V
E
D
L
Y
S
A
I
S
A
N
-
N
K
V
L
-
I
-
G
S
V
GK
G
K
L
A
E
G
I
E
L
R
N
N
D
RSL
I
S
D
V
V
I
V
G
I
P
Y
P
P
P
D
D
Y
L
K
I
-
L
A
Q
R
V
S
L
K
MN
R
E
N
E
E
-
F
L
F
K
I
P
-
A
L
V
T
I
K
Q
A
I
G
R
A
I
R
D
V
N
D
K
C
N
V
W
L
L
D
K
R
F
E
S
-
L
Y
W
K
K
N
L
K
C
L
N
A
N
K
-------------------
28
HHSearch
50.64
30%
-20
- C2 -
2GUI
7
DPO3E_ECOLI
A:
[8-183]
---------
I
T
R
Q
I
V
L
D
T
E
T
T
G
----
M
N
Q
IGAHY
E
-
G
H
K
I
I
E
I
G
A
V
E
V
V
---
N
-------------
R
----
R
L
T
G
--
N
N
F
H
V
Y
L
K
P
--
D
R
--
L
--
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
-----
L
-
D
K
P
-
T
--
F
-
A
E
V
A
D
E
F
M
D
Y
I
R
---------
G
----
A
E
L
-------
V
I
H
N
-
A
-
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
L
K
R
D
---
I
---------
P
K
T
N
T
F
----
C
K
----
V
T
D
S
L
A
V
---
A
R
K
-
M
F
---
P
G
-----------
K
R
N
S
L
D
-
A
L
C
A
-
R
Y
E
I
---
D
N
---
S
KR
T
L
----
H
G
A
L
L
D
A
Q
I
L
A
E
V
Y
L
A
M
T
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
49.55
17%
13
* C1 *
2VSF
2
XPD_THEAC
A:
[5-597]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
V
A
L
E
S
P
T
G
S
G
K
T
I
M
A
L
K
S
A
L
Q
Y
S
S
E
R
K
L
K
V
L
Y
L
V
R
T
N
S
Q
E
E
Q
V
I
-
K
E
L
R
S
L
S
S
T
M
K
I
R
--
A
I
P
M
Q
G
R
V
N
M
C
I
L
Y
R
M
V
D
D
L
H
E
I
N
A
E
S
L
A
K
F
C
N
M
K
K
R
E
V
M
A
G
N
E
A
A
C
P
Y
F
-------
N
F
K
I
R
S
D
E
T
-------
K
R
F
L
F
D
E
L
P
T
A
E
E
F
Y
D
Y
G
E
R
N
N
V
C
P
Y
E
S
M
K
A
A
L
P
D
A
D
I
V
I
A
P
Y
A
Y
F
L
N
R
S
V
A
E
K
-----
F
L
S
H
W
GVSR
N
Q
I
V
------
I
I
L
D
E
A
H
N
L
P
D
I
G
R
S
I
G
S
---------------
F
R
I
S
-
V
E
S
L
N
R
A
D
R
E
A
Q
A
Y
G
D
P
E
L
S
Q
K
I
H
V
S
D
L
I
E
M
I
R
S
A
L
Q
S
M
V
S
E
R
C
G
K
G
D
V
R
I
R
F
Q
E
F
M
E
Y
M
R
I
M
N
K
R
S
-----------
E
R
E
-
I
R
S
L
L
N
Y
L
Y
L
F
G
E
Y
V
E
N
E
-
K
E
K
V
G
K
V
P
---------------
F
S
Y
C
S
S
V
A
S
R
I
-
I
A
F
S
D
Q
D
E
E
K
Y
A
A
I
L
S
-----
P
E
D
G
G
Y
M
Q
A
A
C
L
D
P
S
G
I
L
E
V
L
K
E
S
---
K
T
I
H
M
S
G
T
L
D
---
P
F
D
F
Y
S
D
I
T
G
F
E
---
I
P
F
K
K
I
G
E
I
F
P
P
E
--
N
R
Y
I
A
Y
Y
D
G
V
S
S
K
Y
D
---------
T
L
D
-
E
K
E
L
D
R
M
A
T
V
I
E
D
I
I
L
K
V
K
K
N
T
I
V
Y
F
P
S
Y
S
L
M
D
R
V
E
N
R
V
S
F
E
H
M
K
E
-----
Y
R
G
I
D
Q
K
E
L
Y
S
M
L
K
K
F
R
R
D
H
G
T
I
F
-
A
V
S
G
---
G
R
L
S
E
G
N
E
--------
L
E
M
I
I
L
A
G
L
P
F
P
R
P
D
-
A
I
N
R
S
L
F
D
Y
Y
E
R
K
--
Y
G
K
G
W
-
E
Y
S
V
V
Y
P
T
A
I
K
I
R
Q
E
I
G
R
L
I
R
S
A
E
D
T
G
A
C
V
I
L
D
K
R
A
------
G
Q
F
R
K
F
I
P
D
M
K
K
T
S
D
P
A
S
D
I
Y
N
F
F
I
S
A
Q
A
R
42
HHSearch
49.36
25%
-106
- C2 -
4FZX
4
EXOX_ECOLI
C:
[1-157]
-----------
M
L
R
I
I
D
T
E
T
C
G
----
L
Q
G
---------
G
I
V
E
I
A
S
V
D
V
I
---
D
-------------
G
----
K
I
-
V
--
N
P
M
S
H
L
V
R
P
--
D
R
--
P
--
I
S
P
Q
A
M
A
I
H
R
I
T
E
A
M
-----
V
-----
A
-
D
K
P
-
W
--
I
-
E
D
V
I
P
H
Y
---
Y
G
---------
S
----
E
W
Y
-------
V
A
H
N
-
A
-
S
F
D
R
R
-
V
L
P
E
---------------------
M
----
P
----
G
E
----
W
I
C
T
M
K
L
---
A
R
R
-
L
W
---
P
G
----------
I
K
Y
S
N
M
A
L
Y
K
T
R
-
K
L
N
V
---
Q
T
PPG
L
--
H
H
----
H
R
A
L
Y
D
C
Y
I
T
A
A
L
L
I
D
I
M
N
T
S
G
W
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
46.10
23%
-102
- C2 -
1WLJ
5
ISG20_HUMAN
A:
[6-178]
-----------
E
V
V
A
M
D
C
E
M
V
G
----
L
G
P
-----
H
R
E
S
G
L
A
R
C
S
L
V
------
N
-------------
V
----
H
G
-
A
--
V
L
Y
D
K
F
I
R
P
--
E
G
--
E
--
I
T
D
Y
R
T
R
V
S
G
V
T
P
Q
H
-----
M
-----
V
-
G
A
T
-
P
--
F
-
A
V
A
R
L
E
I
L
Q
L
L
K
---------
G
----
K
L
V
-------
V
G
H
D
-
L
-
K
H
D
F
Q
-
A
L
-------
K
E
D
---
M
---------
S
----
G
----
Y
T
----
I
Y
D
T
S
T
D
----
R
L
-
L
W
---
R
E
----------
A
K
L
V
S
L
R
-
V
L
S
E
-
R
L
L
H
---
K
S
---
I
--
Q
N
SLLG
H
S
S
V
E
D
A
R
A
T
M
E
L
Y
Q
I
S
Q
R
I
R
A
R
-
R
G
L
P
R
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
44.86
30%
6
* C2 *
1J54
6
DPO3E_ECOLI
A:
[7-180]
-----------
R
Q
I
V
L
D
T
E
T
T
G
----
M
N
Q
IGAH-
Y
E
G
H
K
I
I
E
I
G
A
V
E
V
V
---
N
-------------
R
----
R
L
-
T
G-
N
N
F
H
V
Y
L
K
P
--
D
R
--
L
--
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
-----
L
-
D
K
P
-
T
--
F
-
A
E
V
A
D
E
F
M
D
Y
I
R
---------
G
----
A
E
L
-------
V
I
H
N
-
A
-
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
L
K
R
D
---
I
---------
P
----
K
----
T
N
TF
C
K
V
T
D
S
L
A
V
---
A
R
K
-
M
F
---
P
G
-----------
K
R
N
S
L
D
-
A
L
C
A
-
R
Y
E
I
---
D
N
---
S
KR
T
L
----
H
G
A
L
L
D
A
Q
I
L
A
E
V
Y
L
A
M
T
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
42.46
22%
-80
- C2 -
1WLJ
5
ISG20_HUMAN
A:
[6-172]
-----------
E
V
V
A
M
D
C
E
M
V
G
----
L
G
P
-----
H
R
E
S
G
L
A
R
C
S
L
V
N
V
H
---
G
-------------
A
----
V
L
------
Y
D
K
F
I
R
P
--
E
G
--
E
--
I
T
D
Y
R
T
R
V
S
G
V
T
P
Q
H
-----
M
-----
V
-
G
A
T
-
P
--
F
-
A
V
A
R
L
E
I
L
Q
L
L
K
---------
G
----
K
L
V
-------
V
G
H
D
-
L
-
K
H
D
F
Q
-
A
L
K
E
D
M
S
G
Y
---------------------------
T
----
I
Y
D
T
S
T
D
R
L
L
W
R
E
A
K
L
------------------
V
S
L
R
-
V
L
S
E
-
R
L
L
H
KSI
Q
N
S--
L
--
L
G
----
H
S
S
V
E
D
A
R
A
T
M
E
L
Y
Q
I
S
Q
R
I
R
A
R
-
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
42.31
25%
-23
- C2 -
1Y97
-
TREX2_HUMAN
A:
[7-211]
---------
A
E
T
F
V
F
L
D
L
E
A
T
G
----
L
P
S
-----
V
E
-
P
E
I
A
E
L
S
L
F
A
V
H
---
R
S
S
L
E
N
PEHGALVL
P
----
R
V
-
L
--
D
K
L
T
L
C
M
C
P
--
E
R
--
P
--
F
T
A
K
A
S
E
I
T
G
L
S
S
E
G
-----
L
-----
A
-
R
C
R
-
K
AG
F
D
G
A
V
V
R
T
L
Q
A
F
L
S
---------
R
QAGP
I
C
L
-------
V
A
H
N
-
G
F
D
Y
D
F
P
-
L
L
C
A
E
L
R
R
L
G
A
R
---
L
P--------
R
----
D
----
T
V
----
C
L
D
T
L
P
A
---
L
R
G
-
L
D
R
A
H--------------
G
Y
S
L
G
-
S
L
F
H
R
Y
F
R
A
---
E
P
---
S
---------
S
A
E
G
D
V
H
T
L
L
L
I
F
L
H
R
A
A
E
L
L
A
-
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
40.58
25%
-22
- C2 -
3V9W
5
RNT_ECOLI
A:
[36-230]
---------
G
F
Y
P
V
V
I
D
V
E
T
A
G
----
F
N
A
-----
K
T
-
D
A
L
L
E
I
A
A
I
T
L
K
M
D
E
Q
-------------
G
----
W
L
-
M
P
D
T
T
L
H
F
H
V
E
P
FV
G
A
--
N
--
L
Q
P
E
A
L
A
F
N
G
I
D
P
N
D
-----
P
-----
D
R
G
A
V
-
S
--
G
-
Y
E
A
L
H
E
I
F
K
V
V
R
K
G
I
K
A
S
GCN
R
----
A
I
M
-------
V
A
H
N
-
A
-
N
F
D
H
S
-
F
M
M
A
A
A
E
R
A
S
L
K
---
R
NPF------
H
----
P
----
F
A
----
T
F
D
T
A
A
L
---
A
G
L
-
A
L
---
G
-------------
Q
T
V
L
S
-
K
A
C
Q
-
T
A
G
M
---
D
F
D
S-
T
--
Q
A
----
H
S
A
L
Y
D
T
E
R
T
A
V
L
F
C
E
I
V
N
R
W
K
R
-
L
G
G
W
P
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
40.17
26%
-4
- C2 -
2F96
1
RNT_PSEAE
A:
[28-216]
---------
G
Y
L
P
V
V
V
D
V
E
T
G
G
----
F
N
S
-----
A
T
-
D
A
L
L
E
I
A
A
T
T
V
G
M
D
E
K
-------------
G
----
F
L
-
F
P
E
H
T
Y
F
F
R
I
E
P
FE
G
A
--
N
--
I
E
P
A
A
L
E
F
T
G
I
K
L
D
H
PLRMA
V
-----
Q
-
E
E
A
-
A
--
L
-
T
E
I
F
R
G
I
R
K
A
L
K
A
N
GCK----
R
----
A
I
L
-------
V
G
H
N
-
S
-
S
F
D
L
G
-
F
L
N
A
A
V
A
R
T
G
I
K
RNP
F
---------
H
----
P
----
F
S
----
S
F
D
T
A
T
L
---
A
G
L
-
A
Y
---
G
-------------
Q
T
V
L
A
-
K
A
C
Q
-
A
A
G
M
---
E
F
---
D
NR
E
A
----
H
S
A
R
Y
D
T
E
K
T
A
E
L
F
C
G
I
V
N
R
W
K
E
-
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
40.10
21%
-16
- C2 -
4RG8
1
?
A:
[48-249]
---------
C
C
S
L
Y
W
Y
D
Y
E
T
F
G
----
T
D
P
-----
R
R
-
D
R
P
A
Q
F
A
G
I
R
T
D
---
L
-------------
E
LN--
P
I
-
G
--
E
P
V
T
L
F
C
K
P
--
A
R
--
D
VL
P
V
P
E
A
C
L
I
T
G
I
T
P
Q
M
-----
A
-----
A
-
E
R
G
L
K
--
E
-
A
E
F
I
T
R
I
H
E
Q
F
S
VP-------
G
----
T
C
V
-------
A
G
Y
N
N
I
-
R
F
D
D
E
-
V
T
R
H
C
L
Y
R
N
L
F
D
---
P
YEREWRNG
N
S
----
R
----
W
D
----
I
I
D
M
L
R
L
---
T
R
A
-
L
R
---
P
E
G
I
E
W
P
V
D
GSG
K
P
S
L
R
L
E
-
A
L
T
V
-
A
N
G
I
---
Q
H
-------
A
----
H
D
A
L
A
D
V
R
A
T
I
A
V
A
R
L
V
R
E
R
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
39.46
23%
-150
- C2 -
1WLJ
5
ISG20_HUMAN
A:
[7-114]
------------
V
V
A
M
D
C
E
M
V
G
----
L
G
P
-----
H
R
E
S
G
L
A
R
C
S
L
V
N
V
H
---
G
-------------
A
----
V
L
------
Y
D
K
F
I
R
P
--
E
G
--
E
--
I
T
D
Y
R
T
R
V
S
G
V
T
P
Q
H
-----
M
-----
V
-
G
A
T
-
P
--
F
-
A
V
A
R
L
E
I
L
Q
L
L
K
---------
G
----
K
L
V
-------
V
G
H
D
-
L
-
K
H
D
F
Q
-
A
L
K
E
D
M
--
S
G
Y
T
---
I
---------
Y
----
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
39.26
20%
-14
- C2 -
4QOZ
-
ERI1_HUMAN
B:
[73-261]
---------
Y
D
Y
I
C
I
I
D
F
E
A
T
C
EEG-
N
P
P
-----
E
F
V
H
E
I
I
E
F
P
V
V
L
L
N
TH-
T
-------------
L
----
E
I
-
E
--
D
T
F
Q
Q
Y
V
R
P
--
E
I
NT
Q
--
L
S
D
F
C
I
S
L
T
G
I
T
Q
D
Q
-----
V
-----
D
-
R
A
D
-
T
--
F
-
P
Q
V
L
K
K
V
I
D
W
M
K
---------
L
----
K
E
L
GTKYKYS
L
L
T
D
-
G
-
S
W
D
M
S
K
F
L
N
I
Q
C
Q
L
S
R
L
K
---
Y
PP-------
F
----
A
----
K
K
----
W
I
N
I
R
K
S
---
Y
G
N
-
F
Y
---
K
V
------------
Q
T
K
L
T
-
I
M
L
E
-
K
L
G
M
---
D
Y
D--
G
--
R
P
----
H
C
G
L
D
D
S
K
N
I
A
R
I
A
V
R
M
L
Q
D
G
C
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
37.49
32%
7
- C2 -
2GUI
7
DPO3E_ECOLI
A:
[10-143]
-----------
R
Q
I
V
L
D
T
E
T
T
G
MNQI
G
A
H
-----
Y
E
G
H
K
I
I
E
I
G
A
V
E
V
V
---
N
-------------
R
----
R
L
-
T
G-
N
N
F
H
V
Y
L
K
P
--
D
R
--
L
--
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
-----
L
-
D
K
P
-
T
--
F
-
A
E
V
A
D
E
F
M
D
Y
I
R
---------
G
----
A
E
L
-------
V
I
H
N
-
A
-
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
L
K
R
D
---
I
---------
P
----
K
T
N
T
F
C
K
----
V
T
D
S
L
A
V
---
A
R
K
-
M
F
---
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
37.23
24%
30
- C2 -
2F96
1
RNT_PSEAE
A:
[19-219]
RH
P
M
A
R
R
F
R
G
Y
L
P
V
V
V
D
V
E
T
G
G
----
F
N
S
-----
A
T
-
D
A
L
L
E
I
A
A
T
T
V
G
M
--
D
-------------
E
KG
F
L
F
P
-
E
--
H
T
Y
F
F
R
I
E
P
--
F
E
GA
N
--
I
E
P
A
A
L
E
F
T
G
I
K
L
D
H
-----
P
LRMAV
Q
-
E
E
A
-
A
--
L
-
T
E
I
F
R
G
I
R
K
A
L
K
A
N
GCK----
R
----
A
I
L
-------
V
G
H
N
-
S
-
S
F
D
L
G
-
F
L
N
A
A
V
A
R
T
G
I
K
RNP
F
---------
H
----
P
----
F
S
----
S
F
D
T
A
T
L
---
A
G
L
-
A
Y
---
G
Q
----------
T
V
L
A
K
A
C
-
Q
A
A
G
M
E
F
D
N
---
R
-------
E
A
----
H
S
A
R
Y
D
T
E
K
T
A
E
L
F
C
G
I
V
N
R
W
K
E
M
G
G
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
34.93
32%
6
- C2 -
1J54
6
DPO3E_ECOLI
A:
[7-140]
-----------
R
Q
I
V
L
D
T
E
T
T
G
MNQI
G
A
H
-----
Y
E
G
H
K
I
I
E
I
G
A
V
E
V
V
---
N
-------------
R
----
R
L
-
T
G-
N
N
F
H
V
Y
L
K
P
--
D
R
--
L
--
V
D
P
E
A
F
G
V
H
G
I
A
D
E
F
-----
L
-----
L
-
D
K
P
-
T
--
F
-
A
E
V
A
D
E
F
M
D
Y
I
R
---------
G
----
A
E
L
-------
V
I
H
N
-
A
-
A
F
D
I
G
-
F
M
D
Y
E
F
S
L
L
K
R
D
---
I
---------
P
----
K
TNTF
C
K
----
V
T
D
S
L
A
V
---
A
R
K
-
M
F
---
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------