@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22460: (2016-07-04 )
MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPFRLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVCAYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETYDLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVIRVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLKLLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMSILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE
Atome Classification :
(20 SA)
--.........10--.---.---.--......20........30........---40.....-..---.-50---------------------..---------.--...---...60.--------..---..-.----.-.----70.----------.......80.--..-...--..90........100.......110.......120.......----130--.--------------------..--------......140.......150........160.---.---------.....170.......180---...--.-------------------...190...--....200......-.-210........220....---.--..-230..---...----...240---......-...250.-.....-.260-.-----..--.....270.......280-----.-------.-.......290.......300.......310..---------.....320.......330.....---.-.340.......350.......360.......370.....---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
R
K
L
K
I
G
I
T
C
---Y---P---S--VGGS
G
I
I
A
T
E
L
G
K
Q
L
A
EKG
H
E
I
H
F
I
T---SSI
P
F
R
L
-
N
T---Y-H----------------------PN---------
I
--
H
F
H
---
E
V
E
VN
Q
--------
Y
A
---
V
F
-K----Y-P----PY
D
----------
L
T
L
A
S
K
I
A
E
V
--
A
E
-REN--L
D
I
I
H
A
H
YA
L
P
H
A
V
C
A
Y
L
A
K
Q
M
L
K
RNI
G
I
V
T
T
LHG
T
D
I
T
V
L
G----Y----D--------------------P
S
--------
L
K
D
L
I
R
F
A
IESSD
R
V
T
A
V
-
S
S
A
L
A
A
E
T
Y
D
LI---K---------
P
E
K
K
I
E
T
I
Y
N
F
I
D
E
R
V
Y
L
---KK
N
--
T
-------------------
A
A
I
K
E
K
HGI--LPD
E
K
V
V
I
H
V
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
I
R
V
F
R
N
IAG---K--
T
K
-
A
-
K
L
L
---
L
V
G----DGPE-----
K
S
T
A
C
E
-
L
I
R
KYGL-EDQ
V
L
-
M
LG--
N
-----
Q
D
--
R
V
E
D
L
Y
S
I
S
D
L
K
L
L
L
S-------E-------K-ES
F
G
L
V
L
L
E
A
M
ACGV
P
C
IGTNIGG
I
P
E
V
I
K
NN---------V
S
G
F
L
V
DVG
D
V
T
A
A
T
A
R
A
M
S
I
L
E
---
D
-
E
Q
L
S
N
R
F
T
K
A
A
I
E
M
L
E
N
EFS
S
K
K
I
V
S
Q
Y
E
Q
I
Y
A
D
LAEPE---------
1
PsiBlast_PDB
92.24
65%
-134
- C1 -
2JJM
-
BSHA_BACAN
A:
[2-372]
----
K
L
K
I
G
I
T
C
---
Y
---
P
-------
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
T
---
S
G
L
P
-----
K
---
V
-
Y
----------------------
P
N
---------
I
--
Y
F
H
---
E
V
T
V
N
---------------
F
-
Q
----
Y
-
P
----
P
Y
D
----------
L
A
L
A
S
K
M
A
E
V
--
A
Q
-
R
E
N
--
L
D
I
L
H
V
H
Y
A
I
P
H
A
I
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
T
D
I
T
V
L
G
----
S
----
D
--------------------
P
S
--------
L
N
N
L
I
R
F
G
I
E
Q
S
D
V
V
T
A
V
-
S
H
S
L
I
N
E
T
H
E
L
V
---
K
---------
P
N
K
D
I
Q
T
V
Y
N
F
I
D
E
R
V
Y
F
---
K
R
D
--
M
-------------------
T
Q
L
K
K
E
Y
G
I
--
S
---
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
V
T
---
E
--
V
D
-
A
-
K
L
L
---
L
V
G
----
D
G
P
E
-----
F
C
T
I
L
Q
-
L
V
K
N
L
H
I
-
E
D
R
V
L
-
F
L
G
--
K
-----
Q
D
--
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
D
T
T
G
V
A
D
Q
A
I
Q
L
L
K
---
D
-
E
E
L
H
R
N
M
G
E
R
A
R
E
S
V
Y
E
Q
F
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
-------------
21
PsiBlast_CBE
91.33
65%
-126
- C1 -
3MBO
7
BSHA_BACAN
H:
[35-405]
----
K
L
K
I
G
I
T
C
---
Y
---
P
---
S
--
V
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
T
---
S
G
L
P
-----
K
---
V
-
Y
----------------------
P
N
---------
I
--
Y
F
H
---
E
V
T
V
N
----------
S
---
V
F
-
Q
----
Y
-
P
----
P
Y
D
----------
L
A
L
A
S
K
M
A
E
V
--
A
Q
-
R
E
N
--
L
D
I
L
H
V
H
Y
A
I
P
H
A
I
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
T
D
I
T
V
L
G
----
S
----
D
--------------------
P
S
--------
L
N
N
L
I
R
F
G
I
E
Q
S
D
V
V
T
A
V
-
S
H
S
L
I
N
E
T
H
E
L
V
---
K
---------
P
N
K
D
I
Q
T
V
Y
N
F
I
D
E
R
V
Y
F
---
K
R
D
--
M
-------------------
T
Q
L
K
K
E
Y
G
I
--
S
E
S
E
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
V
T
---
E
--
V
D
-
A
-
K
L
L
---
L
V
G
----
D
G
P
E
-----
F
C
T
I
L
Q
-
L
V
K
N
L
H
I
-
E
D
R
V
L
-
F
L
G
--
K
-----
Q
D
--
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
D
T
T
G
V
A
D
Q
A
I
Q
L
L
K
---
D
-
E
E
L
H
R
N
M
G
E
R
A
R
E
S
V
Y
E
Q
F
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
-------------
2
PsiBlast_PDB
90.92
65%
-124
- C1 -
3MBO
7
BSHA_BACAN
A:
[35-405]
----
K
L
K
I
G
I
T
C
---
Y
---
P
---
S
--
V
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
T
---
S
G
L
P
F
--------
V
-
Y
----------------------
P
N
---------
I
--
Y
F
H
---
E
V
T
V
N
Q
--------
Y
S
---
V
F
-
Q
----
Y
-
P
----
P
Y
D
----------
L
A
L
A
S
K
M
A
E
V
--
A
Q
-
R
E
N
--
L
D
I
L
H
V
H
Y
A
I
P
H
A
I
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
T
D
I
T
V
L
G
----
S
----
D
--------------------
P
S
--------
L
N
N
L
I
R
F
G
I
E
Q
S
D
V
V
T
A
V
-
S
H
S
L
I
N
E
T
H
E
L
V
---
K
---------
P
N
K
D
I
Q
T
V
Y
N
F
I
D
E
R
V
Y
F
---
K
R
D
--
M
-------------------
T
Q
L
K
K
E
Y
G
I
--
S
E
S
E
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
V
T
---
E
--
V
D
-
A
-
K
L
L
---
L
V
G
----
D
G
P
E
-----
F
C
T
I
L
Q
-
L
V
K
N
L
H
I
-
E
D
R
V
L
-
F
L
G
--
K
-----
Q
D
--
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
D
T
T
G
V
A
D
Q
A
I
Q
L
L
K
---
D
-
E
E
L
H
R
N
M
G
E
R
A
R
E
S
V
Y
E
Q
F
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
-------------
25
PsiBlast_CBE
90.44
65%
-130
- C1 -
3MBO
3
BSHA_BACAN
D:
[35-405]
----
K
L
K
I
G
I
T
C
---
Y
---
P
---
S
--
V
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
T
---
S
G
L
P
-----
K
---
V
-
Y
----------------------
P
N
---------
I
--
Y
F
H
---
E
V
T
V
N
----------
S
---
V
F
-
Q
----
Y
-
P
----
P
Y
D
----------
L
A
L
A
S
K
M
A
E
V
--
A
Q
-
R
E
N
--
L
D
I
L
H
V
H
Y
A
I
P
H
A
I
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
T
D
I
T
V
L
G
----
S
----
D
--------------------
P
S
--------
L
N
N
L
I
R
F
G
I
E
Q
S
D
V
V
T
A
V
-
S
H
S
L
I
N
E
T
H
E
L
V
---
K
---------
P
N
K
D
I
Q
T
V
Y
N
F
I
D
E
R
V
Y
F
---
K
R
D
--
M
-------------------
T
Q
L
K
K
E
Y
G
I
--
S
E
S
E
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
V
T
---
E
--
V
D
-
A
-
K
L
L
---
L
V
G
----
D
G
P
E
-----
F
C
T
I
L
Q
-
L
V
K
N
L
H
I
-
E
D
R
V
L
-
F
L
G
--
K
-----
Q
D
--
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
D
T
T
G
V
A
D
Q
A
I
Q
L
L
K
---
D
-
E
E
L
H
R
N
M
G
E
R
A
R
E
S
V
Y
E
Q
F
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
-------------
48
HHSearch
89.63
64%
-131
- C1 -
2JJM
-
BSHA_BACAN
A:
[10-374]
---------------
Y
---
P
-------
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
T
---
S
G
L
P
-----
K
---
V
-
Y
----------------------
P
N
---------
I
--
Y
F
H
---
E
V
T
V
N
---------------
F
-
Q
----
Y
-
P
----
P
Y
D
----------
L
A
L
A
S
K
M
A
E
V
--
A
Q
-
R
E
N
--
L
D
I
L
H
V
H
Y
A
I
P
H
A
I
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
T
D
I
T
V
L
G
----
S
----
D
--------------------
P
S
--------
L
N
N
L
I
R
F
G
I
E
Q
S
D
V
V
T
A
V
-
S
H
S
L
I
N
E
T
H
E
L
V
---
K
---------
P
N
K
D
I
Q
T
V
Y
N
F
I
D
E
R
V
Y
F
---
K
R
D
--
M
-------------------
T
Q
L
K
K
E
Y
G
I
--
S
---
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
V
T
---
E
--
V
D
-
A
-
K
L
L
---
L
V
G
----
D
G
P
E
-----
F
C
T
I
L
Q
-
L
V
K
N
L
H
I
-
E
D
R
V
L
-
F
L
G
--
K
-----
Q
D
--
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
D
T
T
G
V
A
D
Q
A
I
Q
L
L
K
---
D
-
E
E
L
H
R
N
M
G
E
R
A
R
E
S
V
Y
E
Q
F
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
L
R
-----------
26
PsiBlast_CBE
89.15
65%
-125
- C1 -
3MBO
6
BSHA_BACAN
C:
[35-405]
----
K
L
K
I
G
I
T
C
---
Y
---
P
---
S
--
V
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
T
---
S
G
L
P
F
R
---
K
---
V
-
Y
----------------------
P
N
---------
I
--
Y
F
H
---
E
V
T
V
N
Q
--------
Y
S
---
V
F
-
Q
----
Y
-
P
----
P
Y
D
----------
L
A
L
A
S
K
M
A
E
V
--
A
Q
-
R
E
N
--
L
D
I
L
H
V
H
Y
A
I
P
H
A
I
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
T
D
I
T
V
L
G
----
S
----
D
--------------------
P
S
--------
L
N
N
L
I
R
F
G
I
E
Q
S
D
V
V
T
A
V
-
S
H
S
L
I
N
E
T
H
E
L
V
---
K
---------
P
N
K
D
I
Q
T
V
Y
N
F
I
D
E
R
V
Y
F
---
K
R
D
--
M
-------------------
T
Q
L
K
K
E
Y
G
I
--
S
E
S
E
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
V
T
---
E
--
V
D
-
A
-
K
L
L
---
L
V
G
----
D
G
P
E
-----
F
C
T
I
L
Q
-
L
V
K
N
L
H
I
-
E
D
R
V
L
-
F
L
G
--
K
-----
Q
D
--
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
D
T
T
G
V
A
D
Q
A
I
Q
L
L
K
---
D
-
E
E
L
H
R
N
M
G
E
R
A
R
E
S
V
Y
E
Q
F
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
-------------
24
PsiBlast_CBE
89.02
65%
-132
- C1 -
3MBO
1
BSHA_BACAN
E:
[35-405]
----
K
L
K
I
G
I
T
C
---
Y
---
P
---
S
--
V
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
T
---
S
G
L
P
F
R
L
-
N
K
---
V
-
Y
----------------------
P
N
---------
I
--
Y
F
H
---
E
V
T
V
N
Q
--------
Y
S
---
V
F
-
Q
----
Y
-
P
----
P
Y
D
----------
L
A
L
A
S
K
M
A
E
V
--
A
Q
-
R
E
N
--
L
D
I
L
H
V
H
Y
A
I
P
H
A
I
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
T
D
I
T
V
L
G
----
S
----
D
--------------------
P
S
--------
L
N
N
L
I
R
F
G
I
E
Q
S
D
V
V
T
A
V
-
S
H
S
L
I
N
E
T
H
E
L
V
---
K
---------
P
N
K
D
I
Q
T
V
Y
N
F
I
D
E
R
V
Y
F
---
K
R
D
--
M
-------------------
T
Q
L
K
K
E
Y
G
I
--
S
E
S
E
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
V
T
---
E
--
V
D
-
A
-
K
L
L
---
L
V
G
----
D
G
P
E
-----
F
C
T
I
L
Q
-
L
V
K
N
L
H
I
-
E
D
R
V
L
-
F
L
G
--
K
-----
Q
D
--
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
D
T
T
G
V
A
D
Q
A
I
Q
L
L
K
---
D
-
E
E
L
H
R
N
M
G
E
R
A
R
E
S
V
Y
E
Q
F
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
-------------
27
PsiBlast_CBE
87.95
65%
-128
- C1 -
3MBO
3
BSHA_BACAN
B:
[35-405]
----
K
L
K
I
G
I
T
C
---
Y
---
P
------
V
G
G
S
G
V
V
G
T
E
L
G
K
Q
L
A
E
R
G
H
E
I
H
F
I
T
---
S
G
L
P
F
----------
Y
----------------------
P
N
---------
I
--
Y
F
H
---
E
V
T
V
N
Q
--------
Y
S
---
V
F
-
Q
----
Y
-
P
----
P
Y
D
----------
L
A
L
A
S
K
M
A
E
V
--
A
Q
-
R
E
N
--
L
D
I
L
H
V
H
Y
A
I
P
H
A
I
C
A
Y
L
A
K
Q
M
I
G
E
R
I
K
I
V
T
T
L
H
G
T
D
I
T
V
L
G
----
S
----
D
--------------------
P
S
--------
L
N
N
L
I
R
F
G
I
E
Q
S
D
V
V
T
A
V
-
S
H
S
L
I
N
E
T
H
E
L
V
---
K
---------
P
N
K
D
I
Q
T
V
Y
N
F
I
D
E
R
V
Y
F
---
K
R
D
--
M
-------------------
T
Q
L
K
K
E
Y
G
I
--
S
E
S
E
K
I
L
I
H
I
S
N
F
-
R
-
K
-
V
K
R
V
Q
D
V
V
Q
A
F
A
K
I
V
T
---
E
--
V
D
-
A
-
K
L
L
---
L
V
G
----
D
G
P
E
-----
F
C
T
I
L
Q
-
L
V
K
N
L
H
I
-
E
D
R
V
L
-
F
L
G
--
K
-----
Q
D
--
N
V
A
E
L
L
A
M
S
D
L
M
L
L
L
S
-------
E
-------
K
-
E
S
F
G
L
V
L
L
E
A
M
A
C
G
V
P
C
I
G
T
R
V
G
G
I
P
E
V
I
Q
H
G
---------
D
T
G
Y
L
C
E
V
G
D
T
T
G
V
A
D
Q
A
I
Q
L
L
K
---
D
-
E
E
L
H
R
N
M
G
E
R
A
R
E
S
V
Y
E
Q
F
R
S
E
K
I
V
S
Q
Y
E
T
I
Y
Y
D
V
-------------
70
Fugue
57.11
19%
-68
- C1 -
2GEK
1
PIMA_MYCS2
A:
[21-393]
--
M
R
I
G
M
V
C
P
Y
S
---
F
---
D
---
V
--
P
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
G
H
E
V
S
V
L
A
---
P
A
S
P
--------------------------------------------------
H
---
V
K
L
P
D
Y
--------
V
V
---
S
G
-
G
----
K
-
A
----
V
F
G
----------
P
A
T
H
R
K
V
K
K
W
--
I
A
-
E
G
D
--
F
D
V
L
H
I
H
E
P
N
A
P
S
L
S
M
L
A
L
Q
A
A
E
---
G
P
I
V
A
T
F
H
-
T
S
T
T
K
S
L
----
T
----
L
--------------------
S
V
--------
F
Q
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
-
S
D
L
A
R
R
W
Q
M
E
A
L
---
G
---------
S
--
D
A
V
E
I
P
N
G
V
D
V
A
S
F
A
---
D
--------------------------
A
P
L
L
D
G
Y
--
P
R
E
G
R
T
V
L
F
L
G
R
Y
D
E
-
P
-
R
K
G
M
A
V
L
L
A
A
L
P
K
L
V
A
---
R
--
F
P
D
V
-
E
I
L
---
I
V
G
----
R
G
D
E
-----
D
E
L
R
E
Q
----
A
G
D
L
-
A
G
H
L
R
-
F
L
G
QV
D
-----
D
A
--
T
K
A
S
A
M
R
S
A
D
V
Y
C
A
P
H
-------
L
-------
G
G
E
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
L
D
A
F
R
R
V
L
A
D
G
---------
D
A
G
R
L
V
P
V
D
D
A
D
G
M
A
A
A
L
I
G
I
L
E
---
D
-
D
Q
L
R
A
G
Y
V
A
R
A
S
E
R
V
H
-
R
Y
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
G
A
G
I
K
V
Q
V
S---
52
HHSearch
53.27
22%
-13
* C1 *
3OKP
1
PIMB_CORGL
A:
[4-380]
----
S
R
K
T
L
V
V
T
NDF
P
---
P
---
R
--
I
G
G
I
Q
S
Y
L
R
D
F
I
A
T
Q
D
--
P
E
S
I
V
V
F
A
---
S
T
Q
N
A
E
E
A
H
A
---
Y
-
D
----------------------
K
T
---------
L
--
D
------
Y
E
V
I
R
--------
W
P
---
R
S
-
V
----
M
-
L
----
P
-
T
----------
P
T
T
A
H
A
M
A
E
I
--
I
R
-
E
R
E
--
I
D
N
V
W
F
G
A
A
A
P
L
A
L
M
A
G
T
A
K
Q
--
A
G
A
S
K
V
I
A
S
T
H
G
H
E
V
G
W
S
M
---------
L
--------------------
P
G
--------
S
R
Q
S
L
R
K
I
G
T
E
V
D
V
L
T
Y
I
-
S
Q
Y
T
L
R
R
F
K
S
A
F
---
G
---------
S
H
P
T
F
E
H
L
P
S
G
V
D
V
K
R
F
T
---
P
A
T
--
P
E
D
K
----------------
S
A
T
R
K
K
L
G
F
--
T
D
T
T
P
V
I
A
C
N
S
R
L
-
V
-
P
-
R
K
G
Q
D
S
L
I
K
A
M
P
Q
V
I
A
A
--
R
--
P
D
-
A
-
Q
L
L
---
I
V
G
----
S
G
R
Y
-----
E
S
T
L
R
R
-
L
A
T
D
--
V
-
S
Q
N
V
K
-
F
L
G
--
R
-----
L
E
Y
Q
D
M
I
N
T
L
A
A
A
D
I
F
A
M
P
A
-------
R
T
R
GGGLD
V
-
E
G
L
G
I
V
Y
L
E
A
Q
A
C
G
V
P
V
I
A
G
T
S
G
G
A
P
E
T
V
T
P
----------
A
T
G
L
V
V
E
G
S
D
V
D
K
L
S
E
L
L
I
E
L
L
D
---
D
-
P
I
R
R
A
A
M
G
A
A
G
R
A
H
V
E
A
E
W
S
W
E
I
M
G
E
R
L
T
N
I
L
Q
S
E
P
------------
55
HHSearch
53.10
18%
-7
- C1 -
2QZS
3
GLGA_ECOLI
A:
[1-477]
-----
M
Q
V
L
H
V
C
---
S
EMF
P
---
L
LK
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
---
P
A
F
P
D
I
R
-
R
G
---
V
-
T
DAQVV
S
R
R
D
T
FA
G
H
I
T
L
L
F
G
H
Y
N
G
---------
V
--
G
I
Y
---
L
I
D
A
P
H
LYDRPGSP
Y
H
DTN
L
F
-
A
----
Y
-
T
D
N
V
L
R
F
A
L
L
G
-------
W
V
G
A
E
M
A
S
G
L
--
D
P
-
F
W
R
--
P
D
V
V
H
A
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
--
G
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
M
F
----
Y
----
A
HHMNDIQLPWSFFNIHGLEF
N
G
--------
Q
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
-
S
P
T
Y
A
R
E
I
T
E
P
Q
FAY
G
M
E
G
L
L
Q
Q
R
H
R
E
G
R
L
S
G
V
L
N
G
V
D
E
K
I
W
S
---
P
E
T
--
D
LLLA
S
R
Y
T
RDTLEDK
A
E
N
K
R
Q
L
Q
I
A
M
G
L
KV
D
D
K
V
P
L
F
A
V
V
S
R
L
-
T
-
S
-
Q
K
G
L
D
L
V
L
E
A
L
P
G
L
L
E
------
Q
G
-
G
-
Q
L
A
---
L
L
G
----
A
G
D
P
V
L
---
Q
E
G
F
L
A
-
A
A
A
E
Y
P
G
-
Q
V
G
V
--
Q
I
G
--
Y
-----
H
E
A
-
F
S
H
R
I
M
G
G
A
D
V
I
L
V
P
S
-------
R
-------
F
-
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
S
D
C
S
L
E
N
L
A
D
GV
A
S
G
F
V
F
E
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
L
W
S
R
-
P
S
L
W
R
F
V
Q
R
---
Q
A
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
K
------------
75
Fugue
52.79
21%
-64
- C1 -
4XSO
2
?
A:
[7-384]
--
M
K
I
L
F
L
D
Q
S
G
-----------
K
--
P
G
G
A
E
L
C
L
I
D
I
A
K
P
Y
R
D
R
-------
A
---
L
V
G
L
F
A
D
-
G
A
---
F
-
K
----------------------
T
L
---------
L
--
E
Q
H
---
H
I
P
V
E
V
--------
F
T
---
N
Q
-
P
----
S
-
L
----
G
Q
L
----------
A
P
L
V
A
K
V
V
Q
T
--
A
H
---
E
--
Y
D
L
I
Y
A
N
---
T
Q
K
A
L
V
V
G
A
I
A
S
F
I
A
R
R
P
L
V
Y
H
L
H
D
I
L
S
P
E
H
F
----
S
----
Q
--------------------
T
N
--------
L
R
V
A
V
N
L
A
N
R
F
A
S
L
V
I
A
N
-
S
Q
A
S
Q
T
A
F
I
Q
A
G
---
G
---------
R
A
E
L
T
K
V
I
Y
N
G
F
D
I
N
L
Y
K
---
T
S
P
--
S
-------------------
D
I
S
K
L
R
Q
Q
L
G-
V
A
N
N
F
V
V
G
H
F
S
R
L
-
S
-
P
-
W
K
G
Q
H
I
L
I
D
A
L
A
Q
C
P
P
---
Q
--
V
T
-
A
-
I
L
V
G
D
A
L
F
G
----
E
Q
D
Y
-----
V
K
E
L
H
Q
-
Q
I
T
R
L
G
L
-
E
N
R
V
K
-
F
L
G
--
F
-----
R
A
--
D
I
P
Q
L
M
A
A
C
D
L
V
A
H
T
S
T------
A
-------
P
-
E
P
F
G
R
V
I
V
E
A
M
L
C
G
K
P
V
V
A
A
K
A
G
G
A
M
E
L
V
E
H
G
---------
V
N
G
F
L
T
T
P
G
E
S
Q
E
L
A
N
I
I
N
T
C
I
E
---
D
-
T
Q
K
T
A
T
I
A
S
N
A
Q
A
I
A
S
Q
R
F
D
V
V
T
I
N
Q
Q
I
A
E
T
L
S
S
L
-------------
68
Fugue
51.35
21%
-7
- C1 -
3C48
3
MSHA_CORGL
A:
[19-438]
S
H
M
R
V
A
M
I
S
M
H
T
---
S
---
P
---
L
--
Q
Q
G
M
N
V
Y
I
L
S
T
A
T
E
L
A
K
Q
G
I
E
V
D
I
Y
T
R
A
T
R
P
S
Q
G
E
I
-
V
R
---
V
-
A
----------------------
E
N
---------
L
--
R
V
I
---
N
I
A
A
G
P
YEG-----
L
S
---
K
E
-
E
----
L
-
P
----
T
Q
L
----------
A
A
F
T
G
G
M
L
S
F
--
T
R
-
R
E
K
VT
Y
D
L
I
H
S
H
Y
W
L
S
G
Q
V
G
W
L
L
R
D
L
W
---
R
I
P
L
I
H
T
A
H
T
L
A
A
V
K
N
S
YDT
P
E
----
S
--------------------
E
A
--------
R
R
I
C
E
Q
Q
L
V
D
N
A
D
V
L
A
V
N
-
T
Q
E
E
M
Q
D
L
M
H
H
Y
---
D
A--------
D
P
D
R
I
S
V
V
S
P
G
A
D
V
E
L
Y
----
S
P
G
--
T
-------------------
E
R
S
R
R
E
L
G
I
--
P
L
H
T
K
V
V
A
F
V
G
R
L
-
Q
-
P
-
F
K
G
P
Q
V
L
I
K
A
V
A
A
L
F
D
---
R
D-
P
D
-
R
-
N
L
R
---
V
I
I
----
C
G
G
P
-----
S
D
T
Y
R
H
-
M
A
E
E
L
G
V
-
E
K
R
I
R
-
F
L
D
P
R
P
-----
P
S
--
E
L
V
A
V
Y
R
A
A
D
I
V
A
V
P
S
-------
F
-------
N
-
E
S
F
G
L
V
A
M
E
A
Q
A
S
G
T
P
V
I
A
A
R
V
G
G
L
P
I
A
V
A
E
G
---------
E
T
G
L
L
V
D
G
H
S
P
H
A
W
A
D
A
L
A
T
L
L
D
---
D
-
D
E
T
R
I
R
M
G
E
D
A
V
E
H
A
R
-
T
F
S
W
A
A
T
A
A
Q
L
S
S
L
Y
N
D
A
I
A
N
E
NVDGETHHG
49
HHSearch
50.58
20%
-2
- C1 -
3C48
3
MSHA_CORGL
A:
[19-428]
---
S
H
M
R
V
A
M
I
S
---
M
HTS
P
LQQ-----
G
M
N
V
Y
I
L
S
T
A
T
E
L
A
K
Q
G
I
E
V
D
I
Y
T
---
R
A
T
R
P
S
Q
-
G
E
IVR
V
-
A
----------------------
E
N
---------
L
--
R
V
I
---
N
I
A
A
G
P
--------
Y
E
---
G
L
-
S
KEE-
L
-
P
----
T
Q
L
----------
A
A
F
T
G
G
M
L
S
F
T
R
R
E
-
K
V
T
--
Y
D
L
I
H
S
H
Y
W
L
S
G
Q
-
V
G
W
L
L
R
D
L
--
W
R
I
P
L
I
H
T
A
H
T
L
A
A
V
K
N
S
----
Y
DT
P
E
S
--------------------
E
A
--------
R
R
I
C
E
Q
Q
L
V
D
N
A
D
V
L
A
V
N
-
T
Q
E
E
M
Q
D
L
M
H
H
Y
---
D
A--------
D
P
D
R
I
S
V
V
S
P
G
A
D
V
E
L
Y
S
---
P
G
----T------------------
E
R
S
R
R
E
L
G
I
--
P
L
H
T
K
V
V
A
F
V
G
R
L
-
Q
-
P
-
F
K
G
P
Q
V
L
I
K
A
V
A
A
L
F
D
R
--
D
PD
R
N
-
L
-
R
V
I
---
I
C
G
----
G
P
S
-------
D
T
Y
R
H
-
M
A
E
E
L
G
V
-
E
K
R
I
R
-
F
L
D
--
P
-----
R
P
P
S
E
L
V
A
V
Y
R
A
A
D
I
V
A
V
P
S
-------
F
-------
N
-
E
S
F
G
L
V
A
M
E
A
Q
A
S
G
T
P
V
I
A
A
R
V
G
G
L
P
I
A
V
A
E
G
---------
E
T
G
L
L
V
D
G
H
S
P
H
A
W
A
D
A
L
A
T
L
L
D
---
D
-
D
E
T
R
I
R
M
G
E
D
A
V
E
H
A
-
R
T
F
S
W
A
A
T
A
A
Q
L
S
S
L
Y
N
D
A
I
A
N
----------
72
Fugue
49.55
20%
15
- C1 -
3OKP
1
PIMB_CORGL
A:
[4-381]
-S
R
K
T
L
V
V
T
N
D
F
---
P
---
P
---
R
--
I
G
G
I
Q
S
Y
L
R
D
F
I
A
T
Q
D
P
E
S
I
V
V
F
A
S
T
Q--
N
A
E
E
A
H
A
-
Y
D
---
K
-
T
----------------------
L
D
---------
Y
--
E
V
I
---
R
W
P
R
S
V
--------
M
-------------------
L
P
T
----------
P
T
T
A
H
A
M
A
E
I
--
I
R
-
E
R
E
--
I
D
N
V
W
F
G
A
A
A
P
L
A
L
M
A
G
T
A
K
Q
A
--
G
A
S
K
V
I
A
S
T
H
G
H
E
V
G
W
-
S
----
M
----
L
--------------------
P
G
--------
S
R
Q
S
L
R
K
I
G
T
E
V
D
V
L
T
Y
I
-
S
Q
Y
T
L
R
R
F
K
S
A
F
---
G
---------
S
H
P
T
F
E
H
L
P
S
G
V
D
V
K
R
F
T
P
A
T
P
E
D
--
K
-------------------
S
A
T
R
K
K
L
G
F
--
T
D
T
T
P
V
I
A
C
N
S
R
L
-
V
-
P
-
R
K
G
Q
D
S
L
I
K
A
M
P
Q
V
I
A
---
A
R-
P
D
-
A
-
Q
L
L
---
I
V
G
----
S
G
R
Y
-----
E
S
T
L
R
R
-
L
A
--
T
D
V
-
S
Q
N
V
K
-
F
L
G
RL
E
-----
Y
Q
--
D
M
I
N
T
L
A
A
A
D
I
F
A
M
P
A
R
T
R
GGGL
D
-------
V
-
E
G
L
G
I
V
Y
L
E
A
Q
A
C
G
V
P
V
I
A
G
T
S
G
G
A
P
E
T
V
T
P
A
----------
T
G
L
V
V
E
G
S
D
V
D
K
L
S
E
L
L
I
E
L
L
D
---
D
-
P
I
R
R
A
A
M
G
A
A
G
R
A
H
V
E
A
E
W
S
W
E
I
M
G
E
R
L
T
N
I
L
Q
S
E
P
R
-----------
64
HHSearch
49.14
22%
-2
- C1 -
3FRO
3
?
A:
[1-432]
---
R
H
M
K
V
L
L
L
G
FEF
L
---
P
V--
K
--
V
G
G
L
A
E
A
L
T
A
I
S
E
A
L
A
S
L
G
H
E
V
L
V
F
T
---
P
S
H
G
R
F
Q
-
G
E
---
E
-
I
----------------------
G
K
I
R
V
FG
E
E
V
Q
V
K
V
S
Y
E
E
R
G
N
L
R
I
Y
R
--------
I
G
G
G-
L
L
-
D
SEDV
Y
G
P
----
G
W
D
G
L
I
R
K
A
V
T
F
G
R
A
S
V
L
L
L
N
D
L
--
L
R
E
E
P
L
--
P
D
V
V
H
F
H
D
W
H
T
V
-
F
A
G
A
L
I
K
K
--
Y
F
K
I
P
A
V
F
T
I
H
R
L
N
K
S
K
L
P
----
A
F
Y
F
-
H
E
-------------------
A
G
LSELAPYP
D
I
D
P
E
H
T
G
G
Y
I
A
D
I
V
T
T
V
-
S
R
G
Y
L
I
D
E
W
G
F
F
---
R
N--------
F
E
G
K
I
T
Y
V
F
N
G
I
D
C
S
F
W
N
---
E
S
Y
--
L
TGS
R
D
E
R
K
-----------
K
S
L
L
S
K
F
G
---
M
D
E
G
V
T
F
M
F
I
G
R
F
-
D
-
R
G
Q
K
G
V
D
V
L
L
K
A
I
E
I
L
S
S
KKE
F
--
Q
E
-
M
-
R
F
I
---
I
I
G
----
K
G
D
P
-----
E
--
L
E
G
-
W
A
R
S
L
E
E
K
H
G
N
V
K
V
I
T
E
--
M
-----
L
S
R
E
F
V
R
E
L
Y
G
S
V
D
F
V
I
I
P
S
-------
Y
-------
F
-
E
P
F
G
L
V
A
L
E
A
M
C
L
G
A
I
P
I
A
S
A
V
G
G
L
R
D
I
I
T
N
----------
E
T
G
I
L
V
K
A
G
D
P
G
E
L
A
N
A
I
L
K
A
L
E
---
L
S
R
S
D
L
S
K
F
R
E
N
C
K
K
R
A
-
M
S
F
S
W
E
K
S
A
E
R
Y
V
K
A
Y
T
G
S
I
D
-----------
59
HHSearch
48.31
23%
16
- C1 -
2X6Q
-
TRET_PYRHO
A:
[39-415]
---
K
G
R
S
F
V
H
V
N
S--
T
---
S
---
F
--
G
G
G
V
A
E
I
L
H
S
L
V
P
L
L
R
S
I
G
I
E
A
R
W
F
V
---
I
E
G
P
T
E
F
-
F
N
---
V
-
T
----------------------
K
T
---------
F
--
H
N
A
---
L
Q
G
N
E
S
--------
L
K
---
L
T
E
E
----
M
-
K
----
E
L
Y
----------
L
N
V
N
R
E
N
S
K
F
--
I
D
-
L
S
S
--
F
D
Y
V
L
V
H
D
P
Q
P
A
A
L
I
E
-
F
----
Y
E
K
K
S
P
W
L
W
R
C
H
I
D
L
S
S
P
N
----------
R
--------------------
E
F
--------
W
E
F
L
-
R
R
F
V
E
K
Y
D
R
Y
I
F
H
L
P
E
Y
V
Q
P
E
L
-----------------
D
R
N
K
A
V
I
M
P
P
S
I
D
P
L
S
E
K
---
N
V
E
LK
Q
T
E
I
----------------
L
R
I
L
E
R
F
D
V
--
D
P
E
K
P
I
I
T
Q
V
S
R
F
-
D
-
P
-
W
K
G
I
F
D
V
I
E
I
Y
R
K
V
K
E
K--
I
--
P
G
-
V
-
Q
L
L
---
L
V
G
----
V
M
A
H
DD
P
E
G
W
I
Y
F
E
K
-
T
L
R
K
I
G
E
-
D
Y
D
V
K
-
V
L
T
--
N
LIGV-
H
A
R
-
E
V
N
A
F
Q
R
A
S
D
V
I
L
Q
M
S
-------
I
-------
R
-
E
G
F
G
L
T
V
T
E
A
M
W
K
G
K
P
V
I
G
R
A
V
G
G
I
K
F
Q
I
V
D
G
---------
E
T
G
F
L
V
R
--
D
A
N
E
A
V
E
V
V
L
Y
L
L
K
---
H
-
P
E
V
S
K
E
M
G
A
K
A
K
E
R
V
R
K
N
F
I
I
T
K
H
M
E
R
Y
L
D
I
L
N
S
L
G
------------
50
HHSearch
48.30
21%
-7
- C1 -
4N9W
2
PIMA_MYCS2
A:
[4-370]
----
A
M
R
I
G
M
V
C
---
P
YSF
D
---
V
--
P
G
G
V
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
G
H
E
V
S
V
L
A
---
P
A
S
P
H
V
K
L
P
D
---
Y
V
V
----------------------
S
G
---------
G
--
K
A
V
---
P
I
P
Y
N
----------
G
---
S
V
-
A
----
R
-
L
----
R
F
G
----------
P
A
T
H
R
K
V
K
K
W
--
I
A
-
E
G
D
--
F
D
V
L
H
I
H
E
P
N
A
P
S
L
S
-
M
L
A
L
Q
--
A
A
E
G
P
I
V
A
T
F
H
T
S
T
T
K
S
L
T
----
L
----
S
--------------------
V
---------
F
Q
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
-
S
----------------------------
A
V
E
I
P
N
G
V
D
V
A
S
F
A
---
D
A
P
--
L
------------------------
L
D
G
Y
--
P
R
E
G
R
T
V
L
F
L
G
R
Y
-
D
E
P
-
R
K
G
M
A
V
L
L
A
A
L
P
K
L
V
A
R
--
F
--
P
D
-
V
-
E
I
L
---
I
V
G
----
R
G
D
E
-----
D
-
E
L
R
E
-
Q
A
G
D
--
L
-
A
G
H
L
R
-
F
L
G
--
Q
-----
V
D
D
A
T
K
A
S
A
M
R
S
A
D
V
Y
C
A
P
H
-------
L
G------
G
-
E
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
L
D
A
F
R
R
V
L
A
D
G
---------
D
A
G
R
L
V
P
V
D
D
A
D
G
M
A
A
A
L
I
G
I
L
E
---
D
-
D
Q
L
R
A
G
Y
V
A
R
A
S
E
R
V
-
H
R
Y
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
G
A
----------
3
PsiBlast_PDB
47.98
31%
-18
- C1 -
2X6Q
-
TRET_PYRHO
A:
[221-410]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
R
F
D
V
--
D
P
E
K
P
I
I
T
Q
V
S
R
F
-
D
-
P
-
W
K
G
I
F
D
V
I
E
I
Y
R
K
V
K
E
---
K
--
I
P
-
G
V
Q
L
L
---
L
V
G
V
M
A
H
D
D
P
E
-----
G
W
I
Y
F
E
K
T
L
R
K
I
G
E
-
D
Y
D
V
K
-
V
L
T
--
N
LIGVH
A
R
--
E
V
N
A
F
Q
R
A
S
D
V
I
L
Q
M
S
-------
I
-------
R
-
E
G
F
G
L
T
V
T
E
A
M
W
K
G
K
P
V
I
G
R
A
V
G
G
I
K
F
Q
I
V
D
G
---------
E
T
G
F
L
V
R
--
D
A
N
E
A
V
E
V
V
L
Y
L
L
K
---
H
-
P
E
V
S
K
E
M
G
A
K
A
K
E
R
V
R
K
N
F
----
I
I
T
K
H
M
E
R
Y
L
D
I
-------------
8
PsiBlast_PDB
47.88
30%
-20
- C1 -
2XA1
-
TRET_PYRHO
A:
[221-410]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
R
F
D
V
--
D
P
E
K
P
I
I
T
Q
V
S
R
F
-
D
-
P
-
W
K
G
I
F
D
V
I
E
I
Y
R
K
V
K
E
---
K
--
I
P
-
G
V
Q
L
L
---
L
V
G
V
M
A
H
D
D
P
E
-----
G
W
I
Y
F
E
K
T
L
R
K
I
G
E
-
D
Y
D
V
K
-
V
L
T
--
N
LIGVH
A
R
--
E
V
N
A
F
Q
R
A
S
D
V
I
L
Q
M
S
-------
I
-------
R
-
E
G
F
G
L
T
V
T
E
A
M
W
K
G
K
P
V
I
G
R
A
V
G
G
I
K
F
Q
I
V
D
G
---------
E
T
G
F
L
V
R
--
D
A
N
E
A
V
E
V
V
L
Y
L
L
K
---
H
-
P
E
V
S
K
E
M
G
A
K
A
K
E
R
V
R
K
N
F
----
I
I
T
K
H
M
E
R
Y
L
D
I
-------------