@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22710: (2016-07-05 )
MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHGRGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMKRQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVAGHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGGIVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHDEIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFSASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80-.-.......90.....--...100..--.....110.......120......-.130.......140.......150..-.....160......-.170.....-..180.......190.......200.......210.......220------...------....230.....-..240.......250.......260.......270.......280.......290.......300.......310.......320.......330..-....-.340.......350.......360.......370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
Y
LTAGESHGP
Q
L
T
T
I
I
EGVPA
G
L
Y
I
TEEDI
N
F
E
L
A
RRQKGHGRGR
R
M
Q
I
E
K
D
Q
A
K
I
M
S
G
V
R
H
A
R
TLGS
P
I
A
L
V
V
ENN
D
W
-
K
-
H
W
T
K
I
MGAAPIT
E
D
--
E
E
K
E
M
K
R
Q
--ISRPRPGHADLN
G
A
I
K
YN
H
R
D
M
R
N
-
V
L
E
R
SSARE
T
T
V
R
V
A
A
G
A
V
A
K
K
I
L
S
E-L
G
I
K
V
AG
H
V
L
Q
I
GA-VKAEKTEYT-
S
I
E
D
L
Q
R
V
T
EESP
V
R
CY
D
E
E
A
G
K
K
M
M
A
A
I
D
E
AKANGDS
I
G
G
I
V
E
V
------
I
VE------GMPVGVG
S
Y
V
H
Y-
D
R
K
L
D
S
K
L
A
A
A
V
L
S
I
N
AFK
G
V
E
F
G
I
G
F
EAAGRNGSEV
H
D
E
I
I
WDEEKGY
T
R
A
T
NRLGGLEGGMTT
G
M
P
I
V
V
R
G
V
MKP
I
P
T
L
Y
K
P
L
K
SVDIETKEPF
S
-
A
SIE-RSDSCAV
P
A
A
S
V
V
A
E
A
A
V
A
W
E
I
A
N
A
V
V
E
QFG
L
D
Q
I
D
R
I
R
E
N
V
E
N
M
R
K
L
S
REF
1
PsiBlast_PDB
85.68
55%
-62
- C5 -
1QXO
9
AROC_STRPN
A:
[2-388]
-
R
Y
L
T
A
G
E
S
H
G
P
R
L
T
A
I
I
E
G
I
P
A
G
L
P
L
T
A
E
D
I
N
E
D
L
R
R
R
Q
G
G
Y
G
R
G
G
R
M
K
I
E
N
D
Q
V
V
F
T
S
G
V
R
H
G
K
T
T
G
A
P
I
T
M
D
V
I
N
K
D
H
-
Q
-
K
W
L
D
I
M
S
A
E
D
I
-
E
D
--
R
L
K
S
-
K
R
K
--
I
T
H
P
R
P
G
H
A
D
L
V
G
G
I
K
Y
R
F
D
D
L
R
N
-
S
L
E
R
S
S
A
R
E
T
T
M
R
V
A
V
G
A
V
A
K
R
L
L
A
E
-
L
D
M
E
I
A
N
H
V
V
V
F
G
G
-
K
E
I
D
V
P
E
N
L
-
T
V
A
E
I
K
Q
R
A
A
Q
S
E
V
S
I
V
N
Q
E
R
E
Q
E
I
K
D
Y
I
D
Q
I
K
R
D
G
D
T
I
G
G
V
V
E
T
------
V
V
G
------
G
V
P
V
G
L
G
S
Y
V
Q
W
-
D
R
K
L
D
A
R
L
A
Q
A
V
V
S
I
N
A
F
K
G
V
E
F
G
L
G
F
E
A
G
Y
R
K
G
S
Q
V
M
D
E
I
L
W
S
K
E
D
G
Y
T
R
R
T
N
N
L
G
G
F
E
G
G
M
T
N
G
Q
P
I
V
V
R
G
V
M
K
P
I
P
T
L
Y
K
P
L
M
S
V
D
I
E
T
H
E
P
Y
K
-
A
T
V
E
-
R
S
D
P
T
A
L
P
A
A
G
M
V
M
E
A
V
V
A
T
V
L
A
Q
E
I
L
E
K
F
S
S
D
N
L
E
E
L
K
E
A
V
A
K
H
R
D
Y
T
K
N
Y
25
HHSearch
82.08
56%
-13
- C5 -
1QXO
9
AROC_STRPN
A:
[1-388]
M
R
Y
L
T
A
G
E
S
H
G
P
R
L
T
A
I
I
E
G
I
P
A
G
L
P
L
T
A
E
D
I
N
E
D
L
R
R
R
Q
G
G
Y
G
R
G
G
R
M
K
I
E
N
D
Q
V
V
F
T
S
G
V
R
H
G
K
T
T
G
A
P
I
T
M
D
V
I
N
K
D
H
-
Q
-
K
W
L
D
I
M
S
A
E
D
I
E
----
D
R
L
K
S
K
R
K
--
I
T
H
P
R
P
G
H
A
D
L
V
G
G
I
K
Y
R
F
D
D
L
R
N
-
S
L
E
R
S
S
A
R
E
T
T
M
R
V
A
V
G
A
V
A
K
R
L
L
A
E
-
L
D
M
E
I
A
N
H
V
V
V
F
G
G
-
K
E
I
D
-
V
P
E
N
L
T
V
A
E
I
K
Q
R
A
A
Q
S
E
V
S
I
V
N
Q
E
R
E
Q
E
I
K
D
Y
I
D
Q
I
K
R
D
G
D
T
I
G
G
V
V
E
T
------
V
V
G
------
G
V
P
V
G
L
G
S
Y
V
Q
W
-
D
R
K
L
D
A
R
L
A
Q
A
V
V
S
I
N
A
F
K
G
V
E
F
G
L
G
F
E
A
G
Y
R
K
G
S
Q
V
M
D
E
I
L
W
S
K
E
D
G
Y
T
R
R
T
N
N
L
G
G
F
E
G
G
M
T
N
G
Q
P
I
V
V
R
G
V
M
K
P
I
P
T
L
Y
K
P
L
M
S
V
D
I
E
T
H
E
P
Y
K
-
A
T
V
E
-
R
S
D
P
T
A
L
P
A
A
G
M
V
M
E
A
V
V
A
T
V
L
A
Q
E
I
L
E
K
F
S
S
D
N
L
E
E
L
K
E
A
V
A
K
H
R
D
Y
T
K
N
Y
6
PsiBlast_PDB
81.41
47%
-16
- C5 -
2QHF
17
AROC_MYCTU
A:
[2-387]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
G
A
R
M
T
F
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
--
E
L
A
D
V
A
R
N
AP
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
-
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
G
P
P
P
-
R
A
E
D
L
P
A
I
-
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
------
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
-
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
-
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
-----
5
PsiBlast_PDB
81.01
47%
-16
- C5 -
2O12
7
AROC_MYCTU
A:
[2-387]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
------
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
--
E
L
A
D
V
A
R
N
AP
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
-
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
G
P
P
P
-
R
A
E
D
L
P
A
I
-
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
------
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
-
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
-
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
-----
4
PsiBlast_PDB
80.61
47%
-19
- C5 -
2O11
7
AROC_MYCTU
A:
[2-387]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
---------
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
--
E
L
A
D
V
A
R
N
AP
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
-
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
G
P
P
P
-
R
A
E
D
L
P
A
I
-
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
------
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
-
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
-
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
-----
3
PsiBlast_PDB
80.33
47%
-20
- C5 -
2G85
-
AROC_MYCTU
A:
[2-387]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
------
F
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
--
E
L
A
D
V
A
R
N
AP
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
-
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
G
P
P
P
-
R
A
E
D
L
P
A
I
-
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
------
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
-
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
-
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
-----
8
PsiBlast_PDB
80.09
46%
-26
- C5 -
4BAJ
2
AROC_MYCTU
A:
[2-387]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
-----------
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
--
E
L
A
D
V
A
R
N
AP
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
-
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
G
P
P
P
-
R
A
E
D
L
P
A
I
-
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
------
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
-
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
------
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
-----
2
PsiBlast_PDB
79.80
47%
-14
- C5 -
1ZTB
-
AROC_MYCTU
A:
[2-387]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
G
A
----
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
--
E
L
A
D
V
A
R
N
AP
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
-
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
G
P
P
P
-
R
A
E
D
L
P
A
I
-
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
------
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
-
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
-
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
-----
7
PsiBlast_PDB
78.88
46%
-24
- C5 -
4BAI
2
AROC_MYCTU
A:
[2-387]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
-----------
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
--
E
L
A
D
V
A
R
N
AP
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
-
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
E
G
P
P
P
-
R
A
E
D
L
P
A
I
-
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
------
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
-
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
-
M
Y
P
G
P
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
-----
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
-----
28
HHSearch
77.91
46%
-18
- C5 -
2O11
7
AROC_MYCTU
A:
[2-391]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
---------
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
L
A
D
V
A
R
N
A
P
--
L
T
R
P
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
-
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
-
S
A
P
Y
-
E
G
P
P
-
P
R
A
E
D
L
P
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
------
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
-
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
Y
P
G
P
-
D
G
V
V
R
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
-
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
-
23
PsiBlast_CBE
66.45
32%
-36
- C5 -
1UM0
2
AROC_HELPY
C:
[8-348]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
-
R
------------------
S
K
D
Y
D
N
I
--
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
-
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
-
I
K
A
K
N
Y
D
F
N
-
H
-------
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
RARSIK
T
N
Q
------
K
L
P
I
G
L
G
Q
G
L
Y
---
A
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
---
D
Q
K
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
-
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
-------------------------
22
PsiBlast_CBE
65.64
32%
-35
- C5 -
1UM0
2
AROC_HELPY
D:
[8-348]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
-
R
------------------
S
K
D
Y
D
N
I
--
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
-
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
-
I
K
A
K
N
Y
D
F
N
-
H
-------
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
RARSIK
T
N
Q
------
K
L
P
I
G
L
G
Q
G
L
Y
---
A
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
---
D
Q
K
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
-
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
-------------------------
31
HHSearch
65.55
34%
-78
- C5 -
1SQ1
2
AROC_CAMJE
A:
[8-354]
L
K
F
T
S
F
G
E
S
H
G
V
A
V
G
C
I
I
D
G
M
P
A
G
V
K
F
D
E
E
F
L
Q
N
E
L
D
K
R
K
G
------------
D
K
A
Q
V
L
S
G
V
F
E
G
Y
T
T
G
H
P
I
A
I
V
V
F
---------------------------------------------------------------
S
A
R
E
S
V
A
R
V
A
G
G
A
V
A
A
M
L
L
R
E
-
F
D
I
C
V
Q
S
G
V
F
G
V
G
T
-
F
V
S
N
-
L
K
E
E
---
E
F
D
F
E
F
A
K
K
S
E
I
F
C
L
D
P
K
L
E
S
D
F
K
N
E
I
L
N
A
R
N
S
K
D
S
V
G
A
A
V
F
T
------
K
V
S
------
G
M
L
I
G
L
G
--
E
V
L
Y
D
-
K
L
D
S
K
L
A
H
A
L
M
G
I
N
A
V
K
A
V
E
I
G
E
G
I
N
A
S
K
M
R
G
S
C
N
N
D
A
L
K
D
-----
G
K
F
L
S
N
H
S
G
G
I
L
G
G
I
S
N
G
E
N
L
I
L
K
T
Y
F
K
P
T
P
----------------------
G
-
R
H
D
P
C
V
G
V
R
G
S
V
V
A
S
A
M
V
R
L
V
L
A
D
C
L
L
L
N
A
S
A
N
L
N
N
----------------
14
PsiBlast_PDB
65.29
32%
-34
- C5 -
1UMF
-
AROC_HELPY
A:
[8-348]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
-
R
------------------
S
K
D
Y
D
N
I
--
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
-
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
-
I
K
A
K
N
Y
D
F
N
-
H
-------
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
IK
T
N
Q
------
K
L
P
I
G
L
G
Q
G
L
Y
---
A
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
---
D
Q
K
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
-
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
-------------------------
24
PsiBlast_CBE
65.05
32%
-35
- C5 -
1UM0
2
AROC_HELPY
B:
[8-348]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
-
R
------------------
S
K
D
Y
D
N
I
--
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
-
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
-
I
K
A
K
N
Y
D
F
N
-
H
-------
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
RARSIK
T
N
Q
------
K
L
P
I
G
L
G
Q
G
L
Y
---
A
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
---
D
Q
K
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
-
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
-------------------------
13
PsiBlast_PDB
64.76
32%
-33
- C5 -
1UM0
2
AROC_HELPY
A:
[8-348]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
-
R
------------------
S
K
D
Y
D
N
I
--
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
-
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
-
I
K
A
K
N
Y
D
F
N
-
H
-------
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
IK
T
N
Q
------
K
L
P
I
G
L
G
Q
G
L
Y
---
A
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
---
D
Q
K
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
-
L
L
K
G
-
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
-------------------------
32
HHSearch
63.75
35%
3
* C5 *
1UM0
2
AROC_HELPY
A:
[8-357]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
R
S
K
D
Y
D
-
N
I
--------------------
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
G
--
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
-
I
K
A
K
-
N
Y
D
-------
F
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
------
R
A
R
S
IKTNQ
K
L
P
I
G
L
G
--
Q
G
L
Y
A
-
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
D
Q
-----
K
G
F
L
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
-
G
N
E
C
E
C
L
L
K
G
-
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
K
I
E
Y
----------------
30
HHSearch
63.30
39%
-22
- C5 -
4OB9
-
?
A:
[10-354]
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
K---------------------------------------------------
G
G
G
--
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
-
E
V
A
E
-
K
L
-------
D
W
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
------
L
A
E
------
K
V
P
V
G
W
G
--
E
P
V
F
D
-
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
S
H
-----
G
F
L
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
---------------------
K
G
-
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
A
D
V
----------------
15
PsiBlast_PDB
62.51
34%
-57
- C5 -
1SQ1
2
AROC_CAMJE
A:
[8-345]
L
K
F
T
S
F
G
E
S
H
G
V
A
V
G
C
I
I
D
G
M
P
A
G
V
K
F
D
E
E
F
L
Q
N
E
L
D
K
R
-
K
G
-----------
D
K
A
Q
V
L
S
G
V
F
E
G
Y
T
T
G
H
P
I
A
I
V
V
F
---------------------------------------------------------------
S
A
R
E
S
V
A
R
V
A
G
G
A
V
A
A
M
L
L
R
E
-
F
D
I
C
V
Q
S
G
V
F
G
V
G
T
F
V
S
N
L
K
E
E
E
F
-
D
F
E
----
F
A
K
K
S
E
I
F
C
L
D
P
K
L
E
S
D
F
K
N
E
I
L
N
A
R
N
S
K
D
S
V
G
A
A
V
F
T
------
K
V
S
------
G
M
L
I
G
L
G
E
-
V
L
Y
-
D
-
K
L
D
S
K
L
A
H
A
L
M
G
I
N
A
V
K
A
V
E
I
G
E
G
I
N
A
S
K
M
R
G
S
C
N
N
D
A
L
-----
K
D
G
K
F
L
S
N
H
S
G
G
I
L
G
G
I
S
N
G
E
N
L
I
L
K
T
Y
F
K
P
T
P
-----------------------G
R
H
D
P
C
V
G
V
R
G
S
V
V
A
S
A
M
V
R
L
V
L
A
D
C
L
L
-------------------------
11
PsiBlast_PDB
61.92
37%
-32
- C5 -
4OB9
-
?
A:
[10-337]
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
-
K
--------------------------------------------------
G
-
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
-
E
V
A
E
K
L
D
W
N
-
E
V
P
N
-------
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
------
L
A
E
------
K
V
P
V
G
W
G
E
P
V
-
F
-
D
R
-
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
---
S
H
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
---------------------
K
G
-
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
---------------------------------