@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23490: (2016-07-06 )
MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLKYEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALGVEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDKDLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVANHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE
Atome Classification :
(75 SA)
.........10.....-...20........30........40.........50........60........70........80........90........100.......110.......120.......130---..-.---.-...140.......150.......160.......170.--..--.--...180.......190.......200.......210.......220.......230.......240--.----......-----..250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
D
R
I
E
R
A
A
A
F
I
K
Q
NL-PESPK
I
G
L
I
LGSG
L
G
I
L
A
D
EIEN
P
-
V
K
L
K
YEDIPEFPVSTVEGHAG
Q
L
V
L
G
TLE
G
V
S
V
I
A
MQ
G
R
F
H
F
YEGYS
M
E
K
V
T
F
P
V
R
V
M
K
ALGV
E
A
L
I
V
TNAAGGVNTEFRAG
D
L
M
I
I
TDH
I
N
---FM-G---T-NPLIGPNEADFGARFPD
M
S
S
A
Y
D
K
D
L
S
S
L
A
E
K
I
A
K
DL--NI--P--IQKG
V
Y
T
AVTGPSYET
P
A
E
V
R
F
L
R
T
MGSDAVGMST
V
P
E
V
I
VANHAG
M
R
V
L
G
I
S
C
I
S
N
A
A
A
G
I
LD----Q----PL
S
H
D
E
-----
V
M
E
V
T
E
K
V
K
A
G
F
L
K
L
V
K
A
I
V
AQYE
2
PsiBlast_PDB
94.58
56%
-129
- C3 -
3LBA
2
?
A:
[40-302]
---
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
R
S
------
G
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
G
R
F
H
Y
Y
E
G
N
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
-
G
---
A
-
N
P
L
M
G
E
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
Y
A
A
G
F
Q
S
----
E
-----
L
N
--------
V
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
--
104
HHSearch
93.87
51%
-126
- C3 -
4M1E
4
?
A:
[27-296]
-
K
S
R
I
D
Q
A
T
A
K
I
S
Q
L
W
-
Q
G
E
P
A
V
G
M
I
L
G
T
G
L
G
G
L
A
E
Q
I
E
Q
D
-
I
A
I
P
Y
S
D
I
P
H
F
P
T
S
T
V
K
S
H
A
G
R
L
V
C
G
R
L
R
G
I
P
I
V
A
M
E
G
R
F
H
Y
Y
E
G
Y
S
L
E
Q
V
T
F
P
V
R
V
M
K
A
M
G
V
K
T
L
L
V
T
N
A
A
G
G
I
N
P
Q
L
D
L
S
D
V
L
I
I
E
D
H
I
N
---
L
M
-
P
---
E
-
N
P
L
R
G
P
N
D
E
E
L
G
P
R
F
P
D
M
S
H
P
Y
D
C
Q
H
M
E
V
A
R
Q
V
A
L
E
L
--
G
I
--
H
--
C
P
K
G
V
F
V
A
V
S
G
P
N
L
E
T
R
A
E
Y
R
M
L
K
L
M
G
A
D
V
V
G
M
S
T
V
P
E
V
L
V
A
V
H
A
G
L
R
V
L
G
F
S
V
V
T
D
L
C
L
P
D
A
L
----
E
----
P
V
E
L
N
K
-----
I
L
E
V
A
A
R
G
G
A
K
L
A
R
L
I
P
E
I
L
P
R
I
A
111
HHSearch
93.57
46%
-102
- C3 -
2P4S
4
?
A:
[93-367]
--
D
T
L
Q
E
I
A
T
Y
L
L
E
R
T
-
E
L
R
P
K
V
G
I
I
C
G
S
G
L
G
T
L
A
E
Q
L
T
D
V
-
D
S
F
D
Y
E
T
I
P
H
F
P
V
S
T
V
A
G
H
V
G
R
L
V
F
G
Y
L
A
G
V
P
V
M
C
M
Q
G
R
F
H
H
Y
E
G
Y
P
L
A
K
C
A
M
P
V
R
V
M
H
L
I
G
C
T
H
L
I
A
T
N
A
A
G
G
A
N
P
K
Y
R
V
G
D
I
M
L
I
K
D
H
I
N
---
L
M
-
G
F
A
G
N
-
N
P
L
Q
G
P
N
D
E
R
F
G
P
R
F
F
G
M
A
N
T
Y
D
P
K
L
N
Q
Q
A
K
V
I
A
R
Q
I
--
G
I
EN
E
--
L
R
E
G
V
Y
T
C
L
G
G
P
N
F
E
T
V
A
E
V
K
M
L
S
M
L
G
V
D
A
I
G
M
S
T
V
H
E
I
I
T
A
R
H
C
G
M
T
C
F
A
F
S
L
I
T
N
M
C
T
M
S
Y
E
E
E
--
E
----
E
H
C
H
D
S
-----
I
V
G
V
G
K
N
R
E
K
T
L
G
E
F
V
S
R
I
V
K
H
I
-
4
PsiBlast_PDB
93.42
49%
-104
- C3 -
4NSN
2
?
A:
[26-295]
Q
E
Q
H
Y
H
E
A
A
S
F
L
S
S
R
L
-
P
G
D
A
K
T
A
I
I
L
G
S
G
L
G
E
L
A
E
K
I
E
N
K
-
T
V
I
P
Y
N
E
I
P
H
F
A
Q
A
T
A
V
G
H
K
G
N
I
I
G
G
I
L
G
G
T
P
V
V
A
M
Q
G
R
F
H
Y
Y
E
G
Y
S
M
D
Q
V
T
F
P
I
R
V
M
K
L
L
G
I
E
N
L
F
V
S
N
A
A
G
G
I
N
T
S
F
K
V
G
D
L
M
I
I
C
D
H
I
N
---
N
L
-----
P
-
N
P
L
I
G
P
N
M
D
M
F
G
V
R
F
P
D
M
T
R
A
Y
D
R
E
F
I
A
K
A
K
G
I
A
Q
E
L
--
N
I
--
P
--
V
K
E
G
V
Y
V
G
L
T
G
P
S
Y
E
T
P
A
E
Y
K
F
W
G
Q
V
G
G
D
A
I
G
M
S
T
V
P
E
V
I
V
A
R
H
T
G
I
R
V
F
G
M
S
V
I
T
N
E
G
Y
H
F
A
D
----
D
----
F
V
N
D
E
Q
D
V
I
R
A
A
N
A
A
S
E
K
M
G
A
I
F
A
R
L
I
A
A
V
-----
3
PsiBlast_PDB
92.98
49%
-110
- C3 -
4NS1
6
?
A:
[26-295]
Q
E
Q
H
Y
H
E
A
A
S
F
L
S
S
R
L
-
P
G
D
A
K
T
A
I
I
L
G
S
G
L
G
E
L
A
E
K
I
E
N
K
-
T
V
I
P
Y
N
E
I
P
H
F
A
Q
A
-----
K
G
N
I
I
G
G
I
L
G
G
T
P
V
V
A
M
Q
G
R
F
H
Y
Y
E
G
Y
S
M
D
Q
V
T
F
P
I
R
V
M
K
L
L
G
I
E
N
L
F
V
S
N
A
A
G
G
I
N
T
S
F
K
V
G
D
L
M
I
I
C
D
H
I
N
---
N
L
-----
P
-
N
P
L
I
G
P
N
M
D
M
F
G
V
R
F
P
D
M
T
R
A
Y
D
R
E
F
I
A
K
A
K
G
I
A
Q
E
L
--
N
I
--
P
--
V
K
E
G
V
Y
V
G
L
T
G
P
S
Y
E
T
P
A
E
Y
K
F
W
G
Q
V
G
G
D
A
I
G
M
S
T
V
P
E
V
I
V
A
R
H
T
G
I
R
V
F
G
M
S
V
I
T
N
E
G
Y
H
F
A
D
----
D
----
F
V
N
D
E
Q
D
V
I
R
A
A
N
A
A
S
E
K
M
G
A
I
F
A
R
L
I
A
A
V
-----
101
HHSearch
92.64
52%
-111
- C3 -
4NSN
2
?
A:
[29-295]
---
H
Y
H
E
A
A
S
F
L
S
S
R
L
-
P
G
D
A
K
T
A
I
I
L
G
S
G
L
G
E
L
A
E
K
I
E
N
K
-
T
V
I
P
Y
N
E
I
P
H
F
A
Q
A
T
A
V
G
H
K
G
N
I
I
G
G
I
L
G
G
T
P
V
V
A
M
Q
G
R
F
H
Y
Y
E
G
Y
S
M
D
Q
V
T
F
P
I
R
V
M
K
L
L
G
I
E
N
L
F
V
S
N
A
A
G
G
I
N
T
S
F
K
V
G
D
L
M
I
I
C
D
H
I
N
---
N
L
-
P
-----
N
P
L
I
G
P
N
M
D
M
F
G
V
R
F
P
D
M
T
R
A
Y
D
R
E
F
I
A
K
A
K
G
I
A
Q
E
L
--
N
I
--
P
--
V
K
E
G
V
Y
V
G
L
T
G
P
S
Y
E
T
P
A
E
Y
K
F
W
G
Q
V
G
G
D
A
I
G
M
S
T
V
P
E
V
I
V
A
R
H
T
G
I
R
V
F
G
M
S
V
I
T
N
E
G
Y
H
F
A
D
D
---
F
----
V
N
D
E
Q
D
-----
V
I
R
A
A
N
A
A
S
E
K
M
G
A
I
F
A
R
L
I
A
A
V
-
44
PsiBlast_CBE
90.94
47%
-79
- C3 -
3K8O
6
PNPH_HUMAN
S:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
107
HHSearch
90.88
57%
-142
- C3 -
3LA8
1
?
A:
[39-303]
--
K
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
-
G
---
A
-
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
Y
A
A
G
F
-----------------------
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
L
-
102
HHSearch
90.78
48%
-90
- C3 -
3FUC
3
PNPH_BOVIN
A:
[8-283]
--
E
D
Y
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
---
L
P
-
G
F
S
G
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
--
G
E
Q
R
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
I
M
D
Y
E
SQ--
G
----
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
S
I
P
69
PsiBlast_CBE
90.38
47%
-82
- C3 -
3PHB
4
PNPH_HUMAN
S:
[46-315]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
66
PsiBlast_CBE
90.27
47%
-78
- C3 -
3PHB
6
PNPH_HUMAN
Y:
[46-315]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
46
PsiBlast_CBE
90.04
47%
-77
- C3 -
3K8O
7
PNPH_HUMAN
E:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
41
PsiBlast_CBE
89.86
47%
-85
- C3 -
3K8O
7
PNPH_HUMAN
Y:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
43
PsiBlast_CBE
89.82
47%
-81
- C3 -
3K8O
7
PNPH_HUMAN
T:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
108
HHSearch
89.80
49%
-86
- C3 -
4LNA
5
?
A:
[24-293]
-
F
E
Q
I
Q
E
T
T
Q
F
I
Q
S
K
I
-
T
L
R
P
A
I
G
I
I
L
G
T
G
L
G
A
L
T
N
E
L
D
I
D
-
T
T
I
P
Y
E
T
I
P
H
F
P
L
S
T
V
---
S
G
K
L
L
I
G
T
L
G
G
K
S
V
V
V
M
Q
G
R
F
H
Y
Y
E
G
Y
T
M
Q
Q
V
T
Y
P
V
R
V
M
H
A
L
G
I
Q
T
L
L
V
S
N
A
A
G
G
M
N
P
T
F
Q
T
S
D
L
M
V
I
D
D
H
I
S
---
L
L
L
P
---
Q
-
N
P
L
I
C
P
N
P
P
I
F
G
D
R
F
P
D
M
S
E
P
Y
R
K
S
L
I
D
L
A
F
S
V
A
A
E
L
--
D
I
--
P
--
L
K
R
G
V
Y
V
S
V
T
G
P
Q
L
E
T
R
A
E
Y
R
M
L
R
Q
W
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
N
Q
L
G
M
D
V
F
G
I
S
V
I
T
D
L
C
F
P
D
T
L
----
E
----
K
A
E
L
V
K
-----
I
L
A
T
A
A
Q
A
E
P
K
L
T
M
L
I
R
E
M
I
G
R
L
-
18
PsiBlast_PDB
89.79
48%
-74
- C3 -
1B8N
3
PNPH_BOVIN
A:
[11-279]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
----
1
PsiBlast_PDB
89.59
56%
-140
- C3 -
3LA8
1
?
A:
[40-302]
---
K
I
Y
E
T
R
D
F
L
T
A
K
G
-
V
Q
K
P
E
F
G
L
I
L
G
S
G
L
G
E
L
A
E
E
I
E
N
A
-
L
V
L
N
Y
A
D
I
P
N
W
G
---------
K
L
I
Y
G
E
L
A
G
R
K
V
L
A
L
Q
-
R
F
H
Y
Y
E
G
-
S
M
E
L
V
T
F
P
I
R
I
M
K
A
L
G
C
Q
G
L
I
V
T
N
A
A
G
G
I
G
--
F
G
P
G
T
L
M
A
I
S
D
H
I
N
---
L
T
-
G
---
A
-
N
P
L
M
G
-
N
L
D
D
F
G
F
R
F
P
D
M
S
N
A
Y
T
A
D
Y
R
E
V
A
H
Q
V
A
D
K
I
--
G
I
--
K
--
L
D
E
G
V
Y
I
G
V
S
G
P
S
Y
E
T
P
A
E
I
R
A
F
K
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
V
H
S
G
L
K
V
L
G
I
S
A
I
T
N
Y
A
A
G
F
-----------------------
V
A
V
T
Q
Q
I
K
E
D
F
K
G
L
V
K
A
I
L
V
E
--
15
PsiBlast_PDB
89.52
48%
-90
- C3 -
2AI1
4
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
67
PsiBlast_CBE
89.49
47%
-78
- C3 -
3PHB
5
PNPH_HUMAN
U:
[46-315]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
37
PsiBlast_CBE
89.38
48%
-75
- C3 -
1A9T
2
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
7
PsiBlast_PDB
89.21
48%
-76
- C3 -
1FXU
4
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
G---
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
97
PsiBlast_CBE
89.06
46%
-96
- C3 -
3GGS
16
PNPH_HUMAN
B:
[33-302]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
Y
E
S
L
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
17
PsiBlast_PDB
89.03
48%
-89
- C3 -
2AI3
4
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
----
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
19
PsiBlast_PDB
88.94
48%
-75
- C3 -
1B8O
2
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
57
PsiBlast_CBE
88.89
47%
-87
- C3 -
1PF7
4
PNPH_HUMAN
E:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
12
PsiBlast_PDB
88.71
48%
-78
- C3 -
1A9P
2
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
16
PsiBlast_PDB
88.58
48%
-83
- C3 -
2AI2
4
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
49
PsiBlast_CBE
88.53
47%
-78
- C3 -
3BGS
4
PNPH_HUMAN
A:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
55
PsiBlast_CBE
88.50
47%
-80
- C3 -
1RSZ
4
PNPH_HUMAN
A:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
5
PsiBlast_PDB
88.50
48%
-78
- C3 -
1A9Q
2
PNPH_BOVIN
A:
[13-280]
-------
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
60
PsiBlast_CBE
88.47
47%
-89
- C3 -
1V3Q
4
PNPH_HUMAN
E:
[10-279]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
56
PsiBlast_CBE
88.39
47%
-79
- C3 -
1RR6
4
PNPH_HUMAN
A:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
13
PsiBlast_PDB
88.36
48%
-73
- C3 -
1A9S
2
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
59
PsiBlast_CBE
88.35
47%
-90
- C3 -
1V41
5
PNPH_HUMAN
E:
[10-279]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
98
PsiBlast_CBE
88.28
46%
-93
- C3 -
3GGS
14
PNPH_HUMAN
A:
[33-302]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
Y
E
S
L
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
61
PsiBlast_CBE
88.22
47%
-91
- C3 -
1V2H
5
PNPH_HUMAN
E:
[10-279]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
54
PsiBlast_CBE
88.18
47%
-78
- C3 -
1RT9
4
PNPH_HUMAN
A:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
47
PsiBlast_CBE
88.07
47%
-96
- C3 -
3INY
4
PNPH_HUMAN
A:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
10
PsiBlast_PDB
88.02
48%
-99
- C3 -
1VFN
3
PNPH_BOVIN
A:
[8-277]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
-------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
-----S
Q
G
-
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
6
PsiBlast_PDB
87.99
48%
-77
- C3 -
1A9R
2
PNPH_BOVIN
A:
[13-280]
-------
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
T
V
P
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
T
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
36
PsiBlast_CBE
87.96
48%
-85
- C3 -
3FUC
2
PNPH_BOVIN
B:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQG
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
58
PsiBlast_CBE
87.83
47%
-81
- C3 -
1V45
4
PNPH_HUMAN
E:
[10-279]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
50
PsiBlast_CBE
87.73
47%
-84
- C3 -
2Q7O
2
PNPH_HUMAN
E:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
35
PsiBlast_CBE
87.71
48%
-83
- C3 -
3FUC
5
PNPH_BOVIN
C:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQG
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
20
PsiBlast_PDB
87.65
48%
-84
- C3 -
3FUC
3
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
--------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
ESQ
G
K
A
N
H
E
E
-----
V
L
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
48
PsiBlast_CBE
87.60
47%
-81
- C3 -
3D1V
4
PNPH_HUMAN
A:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
Y
E
S
L
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
100
PsiBlast_CBE
87.50
46%
-92
- C3 -
3GB9
10
PNPH_HUMAN
A:
[33-302]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
96
PsiBlast_CBE
87.35
46%
-94
- C3 -
3GGS
13
PNPH_HUMAN
C:
[33-302]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
----
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
63
PsiBlast_CBE
87.34
47%
-83
- C3 -
1RCT
4
PNPH_HUMAN
E:
[10-279]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
62
PsiBlast_CBE
87.32
47%
-88
- C3 -
1RFG
4
PNPH_HUMAN
E:
[10-279]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
51
PsiBlast_CBE
87.24
47%
-86
- C3 -
1YRY
4
PNPH_HUMAN
E:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
40
PsiBlast_CBE
87.02
47%
-80
- C3 -
3K8Q
3
PNPH_HUMAN
A:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
23
PsiBlast_CBE
86.97
47%
-85
- C3 -
3KHS
3
?
B:
[5-278]
--
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
L
P
G
L
A
-
G
---
A
-
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
I
S
A
A
R
E
L
--
G
M
--
S
YA
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
V
I
A
S
N
C
E
--------------
E
-----
V
L
R
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
--
64
PsiBlast_CBE
86.95
47%
-85
- C3 -
1PWY
4
PNPH_HUMAN
E:
[10-279]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YESL
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
21
PsiBlast_CBE
86.94
47%
-90
- C3 -
3KHS
2
?
D:
[5-278]
--
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
-------
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
LPG
L
A
-
G
---
A
-
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
I
S
A
A
R
E
L
--
G
M
--
S
YA
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
V
I
A
S
N
C
E
-----------------------
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
--
52
PsiBlast_CBE
86.78
47%
-91
- C3 -
1ULB
3
PNPH_HUMAN
A:
[11-280]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
YES
L
E
----
K
A
N
H
E
E
-----
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
22
PsiBlast_CBE
86.43
47%
-83
- C3 -
3KHS
3
?
C:
[5-278]
--
D
L
A
K
E
T
A
A
W
L
N
K
Q
L
-
Q
I
R
P
V
L
G
I
V
C
G
S
G
L
G
K
I
G
D
S
L
E
T
S
-
I
T
V
A
Y
S
D
I
P
N
F
P
V
G
S
----
A
G
S
L
I
F
G
S
V
N
G
V
S
C
V
C
M
K
G
R
F
H
L
Y
E
G
H
T
A
A
R
A
T
F
P
M
R
V
F
K
A
L
G
V
K
I
V
V
L
T
N
A
A
G
G
L
N
P
S
Y
R
P
G
D
F
M
V
V
R
D
H
I
N
L
P
G
L
A
-
G
---
A
-
N
P
L
T
G
P
N
D
D
T
E
G
E
R
F
P
S
M
T
S
V
Y
D
K
T
L
R
K
Y
A
I
S
A
A
R
E
L
--
G
M
--
S
YA
T
H
E
G
V
Y
C
C
V
N
G
P
S
F
E
T
P
A
E
C
K
I
L
R
L
M
G
S
D
A
V
G
M
S
T
A
P
E
T
I
V
A
K
H
G
G
M
R
C
L
A
V
S
L
I
S
N
V
I
A
S
N
C
E
----
T
------------------
A
G
E
E
A
S
A
R
M
T
A
L
V
K
L
V
I
E
K
--
99
PsiBlast_CBE
85.66
46%
-109
* C3 *
3GB9
14
PNPH_HUMAN
C:
[33-302]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
G
E
I
P
N
F
P
R
S
T
----
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
Q
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
D
K
V
--
I
M
D
YES-----------------
V
L
A
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
I
L
M
A
---
38
PsiBlast_CBE
85.48
48%
-86
- C3 -
2QPL
2
PNPH_BOVIN
A:
[9-278]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
----
G
H
A
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
-----------------
E
A
G
K
Q
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
14
PsiBlast_PDB
85.41
48%
-105
- C3 -
1V48
3
PNPH_BOVIN
A:
[11-280]
-----
Q
D
T
A
K
W
L
L
S
H
T
-
E
Q
R
P
Q
V
A
V
I
C
G
S
G
L
G
G
L
V
N
K
L
T
Q
A
-
Q
T
F
D
Y
S
E
I
P
N
F
P
E
S
------
G
R
L
V
F
G
I
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
F
W
K
V
T
F
P
V
R
V
F
R
L
L
G
V
E
T
L
V
V
T
N
A
A
G
G
L
N
P
N
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
E
-
N
P
L
R
G
P
N
E
E
R
F
G
V
R
F
P
A
M
S
D
A
Y
D
R
D
M
R
Q
K
A
H
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
L
G
G
P
N
F
E
T
V
A
E
C
R
L
L
R
N
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
K
V
--
I
M
D
----
Y
E---------------------
A
A
Q
K
L
E
Q
F
V
S
L
L
M
A
---
93
PsiBlast_CBE
84.78
52%
-107
- C3 -
4EB8
3
PNPH_HUMAN
C:
[46-278]
-----
K
N
T
A
E
Y
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
80
PsiBlast_CBE
84.35
52%
-113
- C3 -
4EAR
3
PNPH_HUMAN
A:
[46-277]
-----
K
N
T
A
E
Y
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
94
PsiBlast_CBE
83.99
52%
-106
- C3 -
4EB8
4
PNPH_HUMAN
B:
[46-278]
-----
K
N
T
A
E
Y
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
113
HHSearch
83.98
43%
-98
- C3 -
1TCV
3
?
A:
[11-285]
---
N
V
K
K
V
A
H
H
I
Q
K
L
T
-
S
I
V
P
E
I
G
I
I
C
G
S
G
L
G
K
L
A
D
G
V
K
D
K
-
I
T
I
P
Y
T
K
I
P
N
F
P
Q
T
S
---
H
S
G
N
L
I
F
G
T
L
S
G
R
K
V
V
V
M
Q
G
R
F
H
M
Y
E
G
Y
S
N
D
T
V
A
L
P
I
R
V
M
K
L
L
G
V
K
I
L
M
V
S
N
A
A
G
G
L
N
R
S
L
K
L
G
D
F
V
I
L
K
D
H
I
Y
---
L
P
-
G
L
G
-
L
N
N
I
L
V
G
P
N
Q
E
A
F
G
T
R
F
P
A
L
S
N
A
Y
D
R
D
L
R
K
L
A
V
Q
V
A
E
E
N
--
G
F
GN
L
--
V
H
Q
G
V
Y
V
M
N
G
G
P
C
Y
E
T
P
A
E
C
T
M
L
L
N
M
G
C
D
V
V
G
M
S
T
I
P
E
V
V
I
A
R
H
C
G
I
Q
V
F
A
V
S
L
V
T
N
I
S
V
L
D
V
E
SD----------------------
G
A
Q
R
A
E
L
M
Q
S
W
F
E
K
I
I
E
K
L
P
75
PsiBlast_CBE
83.71
52%
-108
- C3 -
2A0Y
3
PNPH_HUMAN
A:
[11-243]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
78
PsiBlast_CBE
83.63
52%
-112
- C3 -
4EAR
3
PNPH_HUMAN
C:
[46-277]
-----
K
N
T
A
E
Y
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
LPG
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
79
PsiBlast_CBE
83.01
52%
-114
- C3 -
4EAR
3
PNPH_HUMAN
B:
[46-277]
-----
K
N
T
A
E
Y
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
95
PsiBlast_CBE
82.96
52%
-105
- C3 -
4EB8
3
PNPH_HUMAN
A:
[46-278]
-----
K
N
T
A
E
Y
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
Y
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
Y
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
76
PsiBlast_CBE
82.80
52%
-113
- C3 -
2ON6
1
PNPH_HUMAN
A:
[11-243]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
----
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
77
PsiBlast_CBE
82.47
52%
-106
- C3 -
2A0X
3
PNPH_HUMAN
A:
[11-243]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
73
PsiBlast_CBE
82.05
52%
-106
- C3 -
2A0W
3
PNPH_HUMAN
A:
[11-243]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
72
PsiBlast_CBE
81.21
52%
-110
- C3 -
2OC9
2
PNPH_HUMAN
A:
[11-243]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
------
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
74
PsiBlast_CBE
81.19
52%
-110
- C3 -
2OC4
2
PNPH_HUMAN
A:
[11-243]
-----
K
N
T
A
E
W
L
L
S
H
T
-
K
H
R
P
Q
V
A
I
I
C
G
S
G
L
G
G
L
T
D
K
L
T
Q
A
-
Q
I
F
D
Y
S
E
I
P
N
F
P
R
S
T
V
P
G
H
A
G
R
L
V
F
G
F
L
N
G
R
A
C
V
M
M
Q
G
R
F
H
M
Y
E
G
Y
P
L
W
K
V
T
F
P
V
R
V
F
H
L
L
G
V
D
T
L
V
V
T
N
A
A
G
G
L
N
P
K
F
E
V
G
D
I
M
L
I
R
D
H
I
N
L
P
G
F
S
-
G
---
Q
-
N
P
L
R
G
P
N
D
E
R
F
G
D
R
F
P
A
M
S
D
A
Y
D
R
T
M
R
Q
R
A
L
S
T
W
K
Q
M
GE
Q
R
--
E
--
L
Q
E
G
T
Y
V
M
V
A
G
P
S
F
E
T
V
A
E
C
R
V
L
Q
K
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
V
A
R
H
C
G
L
R
V
F
G
F
S
L
I
T
N
---------------------------------------------------
112
HHSearch
78.51
38%
-46
- C3 -
1G2O
3
PUNA_MYCTU
A:
[11-268]
---
L
A
R
R
A
A
Q
V
I
A
D
R
T
G
I
G
E
H
D
V
A
V
V
L
G
S
G
W
L
P
A
V
A
A
L
G
S
P
T
T
V
L
P
Q
A
E
L
P
G
F
V
P
P
T
A
A
G
H
A
G
E
L
L
S
V
P
I
G
A
H
R
V
L
V
L
A
G
R
I
H
A
Y
E
G
H
D
L
R
Y
V
V
H
P
V
R
A
A
R
A
A
G
A
Q
I
M
V
L
T
N
A
A
G
G
L
R
A
D
L
Q
V
G
Q
P
V
L
I
S
D
H
L
N
---
L
T
-
A
---
R
-
S
P
L
V
G
-------
G
E
F
V
D
L
T
D
A
Y
S
P
R
L
R
E
L
A
R
Q
S
D
------
P
--
Q
--
L
A
E
G
V
Y
A
G
L
P
G
P
H
Y
E
T
P
A
E
I
R
M
L
Q
T
L
G
A
D
L
V
G
M
S
T
V
H
E
T
I
A
A
R
A
A
G
A
E
V
L
G
V
S
L
V
T
N
L
A
A
G
I
T
G
----
E
----
P
L
S
H
A
E
-----
V
L
A
A
G
A
A
S
A
T
R
M
G
A
L
L
A
D
V
I
A
R
F
-
109
HHSearch
73.86
41%
-55
- C3 -
4UC0
1
?
A:
[25-286]
------
P
A
V
D
L
L
I
D
R
L
N
G
L
L
P
R
I
A
I
V
L
G
S
G
L
G
G
L
V
D
E
V
E
N
A
-
V
R
I
P
F
A
D
I
P
G
F
P
--------
K
E
L
V
A
G
L
F
A
G
Q
P
I
I
M
L
A
G
R
V
H
Y
Y
E
E
G
D
A
A
A
M
R
L
P
I
E
T
L
A
S
L
G
V
T
T
L
I
L
T
N
A
A
G
S
L
R
A
D
M
P
P
G
S
V
M
Q
L
I
D
H
I
N
---
F
S
-
G
---
H
-
N
P
L
I
G
E
T
---
G
D
G
R
F
V
G
M
T
Q
A
Y
D
G
E
L
A
E
A
M
R
R
A
A
D
A
E
--
D
I
--
S
--
L
S
S
G
V
Y
M
W
F
S
G
P
S
F
E
T
P
A
E
I
R
M
A
R
T
L
G
A
D
A
V
G
M
S
T
V
P
E
V
I
L
A
R
F
F
G
L
K
V
A
A
A
S
V
I
T
N
Y
G
A
G
M
T
-----------------------
D
M
A
P
I
G
G
R
R
L
V
A
I
L
K
R
M
I
V
D
G
-