@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23910: (2016-07-07 )
MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKEDDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTILGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGYALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRIDEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGGRAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTVNLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK
Atome Classification :
(20 SA)
.........10........20.----------.----------.---.....30--.......---.40-.---.......------50-------.........60....---.-.-..--70-.........80-....-----.-.----.--------..---90----.-------------------...-------------------------------....------.100.......110......----.120....--.-..-.130.......140.-......150--.---.-.....160....---.---.---.170...------------------..---------..180....--.-..190...-----.-...200........210.....------.----------------------------------------------------.---------------220-------.........---------230----.------------------------------------------------------------------------------------------------.....--.240.......250.......260........270..----..--...280..-.....-290.-...-...------300.....-.-.310.-.......320-.....-.----.--330.--.-.....340-....-....350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
N
E
K
R
L
L
E
E
F
L
E
L
VQIDSETK----------
H
----------
E
---
A
E
I
C
K
V
L
--
K
R
K
F
S
DL---GVD-V---KEDD
T
M
D
------
I
--------TGHGA
G
N
L
I
C
T
LKGT---K-Q-T
D
--
T
--
I
Y
F
TSHMDTV--VPGN-----G-V----K--------PV---V-----E-------------------N
G
Y
-------------------------------
V
KTD------G
T
T
I
LGADDK
A
G
L
A
A
M
F
E
A
I
----
K
V
L
-
K
E
EN--I-EH-G
T
I
E
F
I
I
T
VGEESGL-I
G
A
K
A
L
D
R
S
--
M
---
I
-TASYG
Y
A
LDSDG---K---V---
G
N
I
I
V
AA------------------PT---------Q
A
K
V
R
A
A
I
F--G-KTAHAGVE-----P-EKG
I
-
S
A
I
T
I
A
S
K
A
I
S
KMPLGR------I----------------------------------------------------D---------------E---------ETTANIGRF---------EGG----T------------------------------------------------------------------------------------------------Q
T
N
I
V
--
C
D
E
V
H
I
L
A
E
A
R
S
L
V
P
E
K
M
E
A
Q
V
-
Q
K
M
K
A
A
F
E
E
A
A
A
DM----GG--
R
A
E
V
E
I
E
V
-
M
YPGF-KYQD-
G
D
Q
-
V
V
E
------
I
A
K
K
A
A
A
K-I-GRP-S-ELQTSGGGSD-A
N
V
I
A-G----H--GI
P
T
--
V
-
N
L
A
V
G
Y
-
E
-
Q
IHT-KNEKM
P
I
E
E
L
V
K
T
A
E
M
V
V
A
I
I
E
E
AAK
41
HHSearch
83.16
79%
14
- C1 -
3GB0
7
?
A:
[2-373]
M
I
N
Q
E
R
L
V
N
E
F
M
E
L
V
Q
V
D
S
E
T
K
----------
F
----------
E
---
A
E
I
C
K
V
L
--
T
K
K
F
T
D
L
---
G
V
E
-
V
---
F
E
D
D
T
M
A
------
V
--------
T
G
H
G
A
G
N
L
I
C
T
L
P
A
T
---
K
D
G
-
V
D
--
T
--
I
Y
F
T
S
H
M
D
T
V
--
V
P
G
N
-----
G
-
I
----
K
--------
P
S
---
I
-----
K
-------------------
D
G
Y
-------------------------------
I
V
S
D
------
G
T
T
I
L
G
A
D
D
K
A
G
L
A
S
M
F
E
A
I
----
R
V
L
-
K
E
K
N
--
I
-
P
H
-
G
T
I
E
F
I
I
T
V
G
E
E
S
G
L
-
V
G
A
K
A
L
D
R
E
--
R
---
I
-
T
A
K
Y
G
Y
A
L
D
S
D
G
---
K
---
V
---
G
E
I
V
V
A
A
------------------
P
T
---------
Q
A
K
V
N
A
I
I
R
--
G
-
K
T
A
H
A
G
V
A
-----
P
-
E
K
G
V
-
S
A
I
T
I
A
A
K
A
I
A
K
M
P
L
G
R
------
I
----------------------------------------------------
D
---------------
S
---------
E
T
T
A
N
I
G
R
F
---------
E
G
G
----
T
------------------------------------------------------------------------------------------------
Q
T
N
I
V
--
C
D
H
V
Q
I
F
A
E
A
R
S
L
I
N
E
K
M
E
A
Q
V
-
A
K
M
K
E
A
F
E
T
T
A
K
E
M
----
G
G
--
H
A
D
V
E
V
N
V
-
M
Y
P
G
F
-
K
F
A
D
-
G
D
H
-
V
V
E
------
V
A
K
R
A
A
E
K
-
I
-
G
R
T
-
P
-
S
L
H
Q
S
G
G
G
S
D
-
A
N
V
I
A
-
G
----
H
--
G
I
P
T
--
V
-
N
L
A
V
G
Y
-
E
-
E
I
H
T
-
T
N
E
K
I
P
V
E
E
L
A
K
T
A
E
L
V
V
A
I
I
E
E
V
A
K
1
PsiBlast_PDB
82.70
76%
16
- C1 -
3GB0
7
?
A:
[3-373]
-
I
N
Q
E
R
L
V
N
E
F
M
E
L
V
Q
V
D
S
E
T
K
----------
F
----------
E
---
A
E
I
C
K
V
L
--
T
K
K
F
T
D
L
---
G
V
E
-
V
---
F
E
D
D
T
M
A
------
V
--------
T
G
H
G
A
G
N
L
I
C
T
L
P
A
T
---
K
-
D
G
V
D
--
T
--
I
Y
F
T
S
H
M
D
T
V
--
V
P
G
N
-----
G
-
I
----
K
--------
P
S
---
I
-----
K
-------------------
D
G
Y
-------------------------------
I
V
S
D
------
G
T
T
I
L
G
A
D
D
K
A
G
L
A
S
M
F
E
A
I
----
R
V
L
-
K
E
K
N
--
I
-
P
H
-
G
T
I
E
F
I
I
T
V
G
E
E
S
G
L
-
V
G
A
K
A
L
D
R
E
--
R
---
I
-
T
A
K
Y
G
Y
A
L
D
S
D
G
---
K
---
V
---
G
E
I
V
V
A
A
------------------
P
T
---------
Q
A
K
V
N
A
I
I
R
--
G
-
K
T
A
H
A
G
V
A
-----
P
-
E
K
G
V
-
S
A
I
T
I
A
A
K
A
I
A
K
M
P
L
G
R
------
I
----------------------------------------------------
D
---------------
S
---------
E
T
T
A
N
I
G
R
F
---------
E
G
G
----
T
------------------------------------------------------------------------------------------------
Q
T
N
I
V
--
C
D
H
V
Q
I
F
A
E
A
R
S
L
I
N
E
K
M
E
A
Q
V
-
A
K
M
K
E
A
F
E
T
T
A
K
E
M
----
G
G
--
H
A
D
V
E
V
N
V
-
M
Y
P
G
F
-
K
F
A
D
-
G
D
H
-
V
V
E
------
V
A
K
R
A
A
E
K
-
I
-
G
R
T
-
P
-
S
L
H
Q
S
G
G
G
S
D
-
A
N
V
I
A
-
G
----
H
--
G
I
P
T
--
V
-
N
L
A
V
G
Y
-
E
-
E
I
H
T
-
T
N
E
K
I
P
V
E
E
L
A
K
T
A
E
L
V
V
A
I
I
E
E
V
A
K
42
HHSearch
76.33
56%
22
- C1 -
3RZA
10
?
A:
[22-392]
--
N
E
Q
R
L
L
N
T
F
L
E
L
V
Q
I
D
S
E
T
G
----------
N
----------
E
---
S
T
I
Q
P
I
L
--
K
E
K
F
I
A
L
---
G
L
D
-
V
---
K
E
D
E
A
A
K
------
H
--------
P
K
L
G
A
N
N
L
V
C
T
M
N
S
T
IE-----
V
P
--
K
--
L
Y
L
T
S
H
M
D
T
V
--
V
P
A
I
-----
N
-
V
----
K
--------
P
I
---
V
K
----
D
-------------------
D
G
Y
-------------------------------
I
Y
S
D
------
G
T
T
I
L
G
A
D
D
K
A
G
L
A
A
M
L
E
V
L
----
Q
V
I
-
K
E
Q
Q
--
I
-
P
H
-
G
Q
I
Q
F
V
I
T
V
G
E
E
S
G
L
-
I
G
A
K
E
L
N
S
E
--
L
---
L
-
D
A
D
F
G
Y
A
I
D
A
S
A
---
D
---
V
---
G
T
T
V
V
G
A
------------------
P
T
---------
Q
M
L
I
S
A
K
I
I
--
G
-
K
T
A
H
A
S
-
T
-----
P
-
K
E
G
V
-
S
A
I
N
I
A
A
K
A
I
S
R
M
K
L
G
Q
------
V
----------------------------------------------------
D
---------------
E
---------
I
T
T
A
N
I
G
K
F
---------
H
G
G
----
S
------------------------------------------------------------------------------------------------
A
T
N
I
V
--
A
D
E
V
I
L
E
A
E
A
R
S
H
D
P
E
R
I
K
T
Q
V
-
K
H
M
T
D
V
F
E
T
T
A
S
E
L
----
G
G
--
K
A
E
V
T
V
E
Q
-
S
Y
P
G
F
-
K
I
N
D
-
N
E
A
-
V
V
K
------
I
A
Q
E
S
A
R
N
-
L
-
G
L
S
-
A
-
N
T
I
I
S
G
G
G
S
D
-
G
S
I
I
N
-
T
----
F
--
G
I
P
S
--
V
-
I
L
G
V
G
Y
-
E
-
K
I
H
T
-
T
N
E
R
M
P
I
K
S
L
N
L
L
A
S
Q
V
L
E
I
I
K
I
V
A
-
2
PsiBlast_PDB
75.87
53%
20
- C1 -
3RZA
10
?
A:
[21-393]
-
I
N
E
Q
R
L
L
N
T
F
L
E
L
V
Q
I
D
S
E
T
G
----------
N
----------
E
---
S
T
I
Q
P
I
L
--
K
E
K
F
I
A
L
---
G
L
D
-
V
---
K
E
D
E
A
A
K
------
H
--------
P
K
L
G
A
N
N
L
V
C
T
M
N
S
T
IE-----
V
P
--
K
--
L
Y
L
T
S
H
M
D
T
V
--
V
P
A
I
-----
N
-
V
----
K
--------
P
I
---
V
K
----
D
-------------------
D
G
Y
-------------------------------
I
Y
S
D
------
G
T
T
I
L
G
A
D
D
K
A
G
L
A
A
M
L
E
V
L
----
Q
V
I
-
K
E
Q
Q
--
I
-
P
H
-
G
Q
I
Q
F
V
I
T
V
G
E
E
S
G
L
-
I
G
A
K
E
L
N
S
E
--
L
---
L
-
D
A
D
F
G
Y
A
I
D
A
S
A
---
D
---
V
---
G
T
T
V
V
G
A
------------------
P
T
---------
Q
M
L
I
S
A
K
I
I
--
G
-
K
T
A
H
A
S
T
------
P
-
K
E
G
V
-
S
A
I
N
I
A
A
K
A
I
S
R
M
K
L
G
Q
------
V
----------------------------------------------------
D
---------------
E
---------
I
T
T
A
N
I
G
K
F
---------
H
G
G
----
S
------------------------------------------------------------------------------------------------
A
T
N
I
V
--
A
D
E
V
I
L
E
A
E
A
R
S
H
D
P
E
R
I
K
T
Q
V
-
K
H
M
T
D
V
F
E
T
T
A
S
E
L
----
G
G
--
K
A
E
V
T
V
E
Q
-
S
Y
P
G
F
-
K
I
N
D
-
N
E
A
-
V
V
K
------
I
A
Q
E
S
A
R
N
-
L
-
G
L
S
-
A
-
N
T
I
I
S
G
G
G
S
D
-
G
S
I
I
N
-
T
----
F
--
G
I
P
S
--
V
-
I
L
G
V
G
Y
-
E
-
K
I
H
T
-
T
N
E
R
M
P
I
K
S
L
N
L
L
A
S
Q
V
L
E
I
I
K
I
V
A
R
43
HHSearch
50.72
19%
1
* C1 *
3PFO
8
?
A:
[24-428]
--
N
F
N
D
Q
V
A
F
L
Q
R
M
V
Q
F
R
S
V
R
G
----------
E
----------
E
---
A
P
Q
Q
E
W
L
--
A
Q
Q
F
A
D
R
---
G
Y
K
-
V
---
D
T
F
S
L
A
D
VDIASH
P
KAAPMDTI
D
P
A
G
S
M
Q
V
V
A
T
A
D
S
D
---
G
-
K
-
G
R
--
S
--
L
I
L
Q
G
H
I
D
V
V
--
P
E
G
P
VD---
L
-
W
SD--
P
--------
P
Y
EAK
V
-----
R
-------------------
D
G
W
-------------------------------
M
I
G
R
------
G
A
----
Q
D
M
K
G
G
V
S
A
M
I
F
A
L
----
D
A
I
-
R
T
A
G
Y-
A
-
P
D
-
A
R
V
H
V
Q
T
V
T
E
E
E
S
T
G
-
N
G
A
L
S
T
L
M
R
--
G
---
Y
-
R
A
D
A
C
L
I
P
E
P
T
G
-----------
H
T
L
T
R
A
Q
------------------
V
G
---------
A
V
W
F
R
L
R
V
R
--
G
-
T
P
V
H
V
A
-
Y
-----
S
-
E
T
G
T
-
S
A
I
L
S
A
M
H
L
I
R
A
F
E
E
Y
T
------
K
----------------------------------------------------
E
L
N
A
Q
AVRDPWFGQVK
N
---------
P
I
K
F
N
V
G
I
I
---------
K
G
G
----
D
------------------------------------------------------------------------------------------------
W
A
S
S
T
--
A
A
W
C
E
L
D
C
R
L
G
L
L
T
G
D
T
P
Q
E
A
M
-
R
G
I
E
K
C
L
A
D
A
Q
A
T
D
S
F
L
S
E
N
--
P
A
E
L
V
W
S
G
F
Q
A
D
P
A
-
V
C
E
P
-
G
G
V
-
A
E
D
------
V
L
T
A
A
H
K
A
A
F
-
N
A
P
-
L
-
D
A
R
L
S
T
A
V
N
D
-
T
R
Y
Y
S
V
D
----
Y
--
G
I
P
A
--
L
-
C
Y
G
P
Y
G
-
Q
-
G
P
H
A
-
F
D
E
R
I
D
L
E
S
L
R
K
T
T
L
S
I
A
L
F
V
A
E
W
C
-
51
HHSearch
50.20
28%
30
- C1 -
1FNO
4
PEPT_SALTY
A:
[2-405]
----
D
K
L
L
E
R
F
L
H
Y
V
S
L
D
T
Q
S
K
S
GVRQVPST
E
G
----------
Q
---
W
K
L
L
R
L
L
--
K
Q
Q
L
E
E
M
---
G
L
V
-
N
---
I
T
L
S
---------------------
E
K
G
T
L
M
A
T
L
P
A
N
VE-
G
-
D
-
I
P
--
A
--
I
G
F
I
S
H
V
D
T
S
--
P
D
F
S
-----
G
-
K
N
V
--
N
--------
P
Q
---
I
V
E
NYR
G
G
D
I
A
L
G
IGDEVLSPVMFP
V
L
H
Q
-------------------------------
L
L
G
Q
T
L
I
T
T
D
G
K
T
L
L
G
A
D
D
K
A
G
V
A
E
I
M
T
A
L
----
A
V
L
-
K
G
N
P
--
I
-
P
H
-
G
D
I
K
V
A
F
T
P
D
E
E
V
G
K
--
G
A
K
H
F
D
V
E
--
A
---
F
-
G
A
Q
W
A
Y
T
V
D
G
G
G
-------
V
---
G
E
L
E
F
E
N
------------------
F
N
---------
A
A
S
V
N
I
K
I
V
--
G
-
N
N
V
H
P
G
-
T
-----
A
K
G
V
M
V
-
N
A
L
S
L
A
A
R
I
H
A
E
V
P
A
D
E
------
A
--------------------------------------------------------------------
P
---------
E
T
T
E
G
Y
E
G
F
---------
Y
H
L
----
A
------------------------------------------------------------------------------------------------
S
M
K
G
T
--
V
D
R
A
E
M
H
Y
I
I
R
D
F
D
R
K
Q
F
E
A
R
K
-
R
K
M
M
E
I
A
K
K
V
G
K
G
L
HP--
D
C
--
Y
I
E
L
V
I
E
D
-
S
Y
Y
N
M
R
E
K
V
V
-
E
H
P
H
I
L
D
------
I
A
Q
Q
A
M
R
D
-
C
-
H
I
T
-
P
-
E
M
K
P
I
R
G
G
T
D
-
G
A
Q
L
S
-
F
----
M
--
G
L
P
C
--
P
-
N
L
F
T
G
G
-
Y
-
N
Y
H
G
-
K
H
E
F
V
T
L
E
G
M
E
K
A
V
Q
V
I
V
R
I
A
E
L
T
A
-
3
PsiBlast_PDB
50.15
26%
34
- C1 -
1VIX
8
PEPT_ECOLI
A:
[5-408]
-----
K
L
L
E
R
F
L
N
Y
V
S
L
D
T
Q
S
K
----------
A
GVRQVPST
E
G
Q
---
W
K
L
L
H
L
L
--
K
E
Q
L
E
E
M
---
G
L
-----------
I
N
------
V
--------
T
L
S
E
K
G
T
L
M
A
T
L
P
A
N
---
V
-
P
-
G
D
I
P
A
--
I
G
F
I
S
H
V
D
T
S
PD
C
S
G
K
-----
N
-
V
----
N
--------
P
Q
---
I
-----
V
-------------------
E
N
Y
RG
G
D
I
A
L
G
IGDEVLSPVMFP
V
L
H
Q
L
LG
Q
T
L
-
I
T
T
D
------
G
K
T
L
L
G
A
D
D
K
A
G
I
A
E
I
M
T
A
L
----
A
V
L
-
Q
Q
K
K
--
I
-
P
H
-
G
D
I
R
V
A
F
T
P
D
E
E
V
G
K
--
G
A
K
H
F
D
V
D
--
A
---
F
-
D
A
R
W
A
Y
T
V
D
G
G
G
-------
V
---
G
E
L
E
F
E
N
------------------
F
N
---------
A
A
S
V
N
I
K
I
V
--
G
-
N
N
V
H
P
G
T
A
-----
K
-
G
V
M
V
-
N
A
L
S
L
A
A
R
I
H
A
E
V
P
A
D
E
------
S
----------------------------------------------------
P
---------------
E
---------
M
T
E
G
Y
E
G
F
Y
---------
H
L
A
----
S
------------------------------------------------------------------------------------------------
M
K
G
T
V
E
R
A
D
M
H
Y
I
I
---
R
D
F
D
R
K
Q
F
E
A
R
K
-
R
K
M
M
E
I
A
K
K
V
G
K
------
G
L
--
H
P
D
C
Y
I
E
L
-
V
I
E
D
S
-
Y
Y
N
M
-
R
E
K
-
V
V
E
H
P
H
I
L
D
I
A
Q
Q
A
M
R
D
-
C
-
D
I
E
-
P
-
E
L
K
P
I
R
G
G
T
D
-
G
A
Q
L
S
-
F
----
M
--
G
L
P
C
--
P
-
N
L
F
T
G
G
-
Y
-
N
Y
H
G
-
K
H
E
F
V
T
L
E
G
M
E
K
A
V
Q
V
I
V
R
I
A
E
L
T
A
Q
45
HHSearch
48.98
24%
23
- C1 -
1CG2
5
CBPG_PSES6
A:
[17-390]
--
E
Q
P
A
V
I
K
T
L
E
K
L
V
N
I
E
T
G
T
G
----------
D
----------
A
E
G
I
A
A
A
G
N
F
L
--
E
A
E
L
K
N
L
---
G
F
T
-
V
---
T
R
S
K
S
A
----------------
G
L
V
V
G
D
N
I
V
G
K
I
K
G
R
-----
G
-
G
K
--
N
--
L
L
L
M
S
H
M
D
T
V
--
Y
L
K
G
-----
I
-
L
AK--
A
--------
P
F
R
--
V
-----
E
-------------------
G
D
K
-------------------------------
A
Y
G
P
------
G
I
----
A
D
D
K
G
G
N
A
V
I
L
H
T
L
----
K
L
L
-
K
E
Y
G
V-
R
-
D
Y
-
G
T
I
T
V
L
F
N
T
D
E
E
K
G
S
-
F
G
S
R
D
L
I
Q
E
--
E
---
A
K
L
A
D
Y
V
L
S
F
E
P
T
S
---
A
G--
D
---
E
K
L
S
L
G
T
------------------
S
G
---------
I
A
Y
V
Q
V
N
I
T
--
G
-
K
A
S
H
A
G
A
A
-----
P
-
E
L
G
V
-
N
A
L
V
E
A
S
D
L
V
L
R
T
M
N
I
D
------
D
K---------------------------------------------------
A
---------------
K
---------
N
L
R
F
N
W
T
I
A
---------
K
A
G
----
N
------------------------------------------------------------------------------------------------
V
S
N
I
I
--
P
A
S
A
T
L
N
A
D
V
R
Y
A
R
N
E
D
F
D
A
A
M
-
K
T
L
E
E
R
A
Q
Q
K
K
L
-
P
----
E
A
--
D
V
K
V
I
V
T
R
-
G
R
P
A
F
-
N
A
G
E
G
G
K
K
-
L
V
D
------
K
A
V
A
Y
Y
K
E
-
A
-
G
G
T
L
G
-
V
E
E
R
T
G
G
G
T
D
-
A
A
Y
A
A
-
L
----
S
--
G
K
P
V
--
I
E
S
L
G
L
P
G
-
F
-
G
Y
H
S
D
K
A
E
Y
V
D
I
S
A
I
P
R
R
L
Y
M
A
A
R
L
I
M
D
L
G
-
49
HHSearch
47.95
21%
24
- C1 -
4PQA
4
DAPE_NEIMB
A:
[2-376]
--
T
E
T
Q
S
L
E
L
A
K
E
L
I
S
R
P
S
V
T
P
----------
D
----------
D
---
R
D
C
Q
K
L
L
--
A
E
R
L
H
K
I
---
G
F
A
-
A
---
E
E
L
H
F
-------------------
G
D
T
K
N
I
W
L
R
R
-
G
T
-----
K
-
A
P
--
V
--
V
C
F
A
G
H
T
D
V
V
--
P
T
G
P
VE---
K
-
W
DS--
P
--------
P
F
E
P
A
E
-----
R
-------------------
D
G
R
-------------------------------
L
Y
G
R
------
G
A
----
A
D
M
K
T
S
I
A
C
F
V
T
A
C
----
E
R
F
-
V
A
K
H
--
P
N
H
Q
-
G
S
I
A
L
L
I
T
S
D
E
E
G
D
A
L
D
G
T
T
K
V
V
D
V
L
K
A
R
D-
E
-
L
I
D
Y
C
I
V
G
E
P
T
A
---
V
DKL
G
---
D
M
I
K
N
G
R
------------------
R
G
---------
S
L
S
G
N
L
T
V
K
--
G
-
K
Q
G
H
I
A
-
Y
-----
P
-
H
L
A
I
-
N
P
V
H
T
F
A
P
A
L
L
E
L
T
Q
E
V
WDEGNE
Y
----------------------------------------------------
F
---------------
P
---------
P
T
S
F
Q
I
S
N
I
---------
N
G
G
----
T
G-----------------------------------------------------------------------------------------------
A
T
N
V
I
--
P
G
E
L
N
V
K
F
N
F
R
F
S
T
E
S
T
E
A
G
L
K
-
Q
R
V
H
A
I
L
D
K
H
--------
G
V
--
Q
Y
D
L
Q
W
S
C
-
S
G
Q
P
F
-
L
T
-
Q
-
A
G
K
-
L
T
D
------
V
A
R
A
A
I
A
E
T
C
-
G
I
E
-
A
-
E
L
S
T
T
G
G
T
S
D
-
G
R
F
I
K
-
A
----
I
--
A
Q
E
L
--
I
-
E
L
G
P
S
N
-
A
-
T
I
H
Q
-
I
N
E
N
V
R
L
N
D
I
P
K
L
S
A
V
Y
E
G
I
L
A
R
L
L
-
61
HHSearch
47.59
22%
-5
- C1 -
3MRU
2
?
A:
[11-488]
-
L
S
P
A
P
L
W
Q
F
F
D
K
I
C
S
I
P
H
P
S
K
----------
H
----------
E
---
E
A
L
A
Q
Y
I
--
V
T
W
A
T
E
Q
---
G
F
D
-
V
---
R
R
D
P
T
----------------------
G
N
V
F
I
K
K
P
A
T
PGM
E
-
N
-
K
K
--
G
--
V
V
L
Q
A
H
I
D
M
V
--
P
Q
K
N
E
D
T
D
H
D
-
F
TQ--
D
--------
P
I
Q
P
Y
I
-----
D
-------------------
G
E
W
-------------------------------
V
T
A
K
------
G
T
-
T
L
G
A
D
N
G
I
G
M
A
S
C
L
A
V
L
----
A
S
K
-
E
-----
I
-
K
H
-
G
P
I
E
V
L
L
T
I
D
E
E
A
G
M
-
T
G
A
F
G
L
E
A
G
--
W
---
L
-
K
G
D
I
L
L
N
T
D
S
E
Q
---
E
-------
G
E
V
Y
M
G
C
A
G
G
I
D
G
A
M
T
F
D
I
T
R
D
A
IP
A
G
---------
F
I
T
R
Q
L
T
L
K
--
G
L
K
G
G
H
S
G
C
D
-----
I
-
H
T
G
R
G
N
A
N
K
L
I
G
R
F
L
A
G
H
A
Q
E
---------------------------------------------------------------------------------------
L
D
L
R
L
V
E
F
---------
R
G
G
----
S
L
RNAIPR
E
A
F
V
T
V
A
L
P
AEN
Q
D
K
L
A
E
L
F
N
Y
Y
T
E
L
L
K
T
E
LGKIET
D
I
V
T
F
N
E
E
V
ATDAQVFA
I
A
D
Q
Q
R
F
I
A
A
L
N
A
CPNGVMRMSDEVEGVVE
T
S
L
N
VG
V
I
T
T
E
--
E
N
K
V
T
V
L
C
L
I
R
S
L
I
D
S
G
R
S
Q
V
E
-
G
M
L
Q
S
V
A
E
L
A
--------
G
A
----
Q
I
E
F
S
G
-
A
Y
P
G
W
-
K
P
D
A
-
D
S
E
-
I
M
A
------
I
F
R
D
M
Y
E
G
-
I
Y
G
H
K
-
P
-
N
I
M
V
I
H
A
G
L
E
-
C
G
L
F
K
-
E
----
P
YP
N
M
D
M
--
V
-
S
F
G
P
T
I
-
K
-
F
P
H
S
-
P
D
E
K
V
K
I
D
T
V
Q
L
F
W
D
Q
M
V
A
L
L
E
A
I
P
E
16
PsiBlast_PDB
46.62
23%
31
- C1 -
4PPZ
3
DAPE_NEIMB
A:
[2-372]
--
T
E
T
Q
S
L
E
L
A
K
E
L
I
S
R
P
S
V
T
P
----------
D
----------
D
---
R
D
C
Q
K
L
L
--
A
E
R
L
H
K
I
---
G
F
A
-
A
---
E
E
L
H
F
G
D
------
T
--------
K
N
------
I
W
L
R
R
G
T
---
K
---
A
P
--
V
--
V
C
F
A
G
H
T
D
-
V
--
V
P
T
G
-----
P
-
V
----
E
KWDSPPFE
P
A
---
E
-----
R
-------------------
D
G
R
-------------------------------
L
Y
G
R
------
G
----
A
A
D
M
K
T
S
I
A
C
F
V
T
A
C
----
E
R
F
-
V
A
K
H
--
P
-
N
H
Q
G
S
I
A
L
L
I
T
S
D
E
E
------
G
D
A
L
D
G
T
--
T
---
K
-
V
V
D
V
L
K
A
R
D
E
-----
L
---
I
---
D
Y
C
I
V
G
E
------------------
P
T
AVDKLGD
M
I
K
N
G
R
R
G
S
L
S
--
G
-
N
L
T
V
K
G
K
Q
G
HIAY
P
-
H
L
A
I
-
N
P
V
H
T
F
A
P
A
L
L
E
L
T
Q
E
V
------
W
----------------------------------------------------
D
---------------
E
GNEYFP---
P
T
S
F
Q
I
S
N
I
---------
N
G
G
----
T
G-----------------------------------------------------------------------------------------------
A
T
N
V
I
--
P
G
E
L
N
V
K
F
N
F
R
-
F
S
T
E
S
T
E
A
G
L
K
Q
R
V
H
A
I
L
D
K
----
H
----
G
V
--
Q
Y
D
L
Q
W
S
C
-
S
G
Q
P
F
-
L
T
Q
A
-
G
-
K
-
L
T
D
------
V
A
R
A
A
I
A
E
T
C
-
G
I
E
-
A
-
E
L
S
T
T
G
G
T
S
D
-
G
R
F
I
K
-
A
----
I
--
A
Q
E
L
--
I
-
E
L
G
P
S
N
-
A
-
T
I
H
Q
-
I
N
E
N
V
R
L
N
D
I
P
K
L
S
A
V
Y
E
G
I
L
-----
5
PsiBlast_PDB
45.84
24%
35
- C1 -
3IFE
7
PEPT_BACAN
A:
[26-426]
---
K
E
E
L
I
E
R
F
T
R
Y
V
K
I
D
T
Q
S
N
----------
E
----------
D
---
S
H
T
V
P
T
T
P
G
Q
I
E
F
G
K
L
---
L
V
E
E
L
---
K
E
V
G
L
T
E
------
V
--------
T
M
D
D
N
G
Y
V
M
A
T
L
P
A
N
---
T
-
D
-
K
D
--
V
P
V
I
G
F
L
A
H
L
D
T
A
TD
F
T
G
K
-----
N
-
V
----
K
--------
P
Q
---
I
-----
H
-------------------
E
N
F
DGNAITLNEELN
I
V
L
T
PEQFPELPSYKGHT
I
I
T
T
D
------
G
T
T
L
L
G
A
D
D
K
A
G
L
T
E
I
M
V
A
M
----
N
Y
L
I
H
N
P
Q
--
I
-
K
H
-
G
K
I
R
V
A
F
T
P
D
E
E
I
G
R
--
G
P
A
H
F
D
V
E
--
A
---
F
-
G
A
S
F
A
Y
M
M
D
G
-
G
---
P
---
L
---
G
G
L
E
Y
E
S
------------------
F
N
---------
A
A
G
A
K
L
T
F
N
--
G
-
T
N
T
H
P
G
T
A
-----
K
-
N
K
M
R
-
N
A
T
K
L
A
M
E
F
N
G
H
L
P
V
E
E
------
A
----------------------------------------------------
P
---------------
E
---------
Y
T
E
G
Y
E
G
F
Y
H
L
L
S
L
N
G
D
V
E
Q
S
----
K
------------------------------------------------------------------------------------------------
A
Y
Y
I
I
--
R
D
F
D
R
K
N
F
E
A
R
K
N
T
I
E
N
I
V
K
Q
M
-
Q
E
-
K
Y
G
Q
D
A
V
V
L
E
M
----
N
D
--
Q
Y
Y
N
M
L
E
K
-
I
E
P
V
--------
R
E
-
I
V
D
------
I
A
Y
E
A
M
K
S
-
L
-
N
I
E
-
P
-
N
I
H
P
I
R
G
G
T
D
-
G
S
Q
L
S
-
Y
----
M
--
G
L
P
T
--
P
-
N
I
F
T
G
G
-
E
-
N
Y
H
G
-
K
F
E
Y
V
S
V
D
V
M
E
K
A
V
Q
V
I
I
E
I
------
48
HHSearch
45.47
19%
20
- C1 -
2RB7
2
?
A:
[2-360]
M
S
S
M
Q
H
I
V
E
L
T
S
D
L
I
R
F
P
S
M
H
S
R
P
E
-------
Q
----------
I
---
S
R
C
A
G
F
I
--
M
D
W
C
A
Q
N
---
G
I
H
-
A
---
E
R
M
D
H
-------------------
D
G
I
P
S
V
M
V
L
P
-
E
K
-----
G
-
R
A
--
G
--
L
L
L
M
A
H
I
D
V
V
--
D
A
E
D
D----
L
-
F
----
V
--------
P
R
---
V
-----
E
-------------------
N
D
R
-------------------------------
L
Y
G
R
------
G
A
----
N
D
D
K
Y
A
V
A
L
G
L
V
M
F
R
D
R
L
N
A
L
-
K
A
A
G
RS
Q
-
K
D
-
M
A
L
G
L
L
I
T
G
D
E
E
I
G
G
M
N
G
A
A
K
A
L
P
---
L
---
I
-
R
A
D
Y
V
V
A
L
D
G
G
N
---
P
-------
Q
Q
V
I
T
K
E
------------------
K
G
---------
I
I
D
I
K
L
T
C
T
--
G
-
K
A
A
H
G
A
-
R
-----
P
-
W
M
G
V
-
N
A
V
D
L
L
M
E
D
Y
T
R
L
K
T
L
F
------
A
EENED-----------------------------------------------
H
---------------
W
---------
H
R
T
V
N
L
G
R
I
---------
R
A
G
----
E
------------------------------------------------------------------------------------------------
S
T
N
K
V
--
P
D
V
A
E
G
W
F
N
I
R
V
T
E
H
D
D
P
G
A
L
I
-
D
K
I
R
K
T
V
S
G
T
-------------
V
S
I
V
--
R
--
T
V
P
V
-
F
L
A
A
-
D
S
P
-
Y
T
E
------
R
L
L
A
L
S
G
A
---------
T
A
G
K
A
H
G
A
S
D
-
A
R
Y
L
G
-
E
----
N
--
G
L
T
G
--
V
-
V
W
G
A
E
G
-
F
N
T
L
H
S
-
R
D
E
C
L
H
I
P
S
L
Q
S
I
Y
D
P
L
M
Q
L
A
R
E
M
E
E
17
PsiBlast_PDB
45.23
23%
32
- C1 -
4PQA
4
DAPE_NEIMB
A:
[2-372]
--
T
E
T
Q
S
L
E
L
A
K
E
L
I
S
R
P
S
V
T
P
----------
D
----------
D
---
R
D
C
Q
K
L
L
--
A
E
R
L
H
K
I
---
G
F
A
-
A
---
E
E
L
H
F
G
D
------
T
--------
K
N
------
I
W
L
R
R
G
T
---
K
---
A
P
--
V
--
V
C
F
A
G
H
T
D
-
V
--
V
P
T
G
-----
P
-
V
----
E
KWDSPPFE
P
A
---
E
-----
R
-------------------
D
G
R
-------------------------------
L
Y
G
R
------
G
----
A
A
D
M
K
T
S
I
A
C
F
V
T
A
C
----
E
R
F
-
V
A
K
H
--
P
-
N
H
Q
G
S
I
A
L
L
I
T
S
D
E
E
------
G
D
A
L
D
G
T
--
T
---
K
-
V
V
D
V
L
K
A
R
D
E
-----
L
---
I
---
D
Y
C
I
V
G
E
------------------
P
T
AVDKLGD
M
I
K
N
G
R
R
G
S
L
S
--
G
-
N
L
T
V
K
G
K
Q
G
HIAY
P
-
H
L
A
I
-
N
P
V
H
T
F
A
P
A
L
L
E
L
T
Q
E
V
------
W
----------------------------------------------------
D
---------------
E
GNEYFP---
P
T
S
F
Q
I
S
N
I
---------
N
G
G
----
T
G-----------------------------------------------------------------------------------------------
A
T
N
V
I
--
P
G
E
L
N
V
K
F
N
F
R
-
F
S
T
E
S
T
E
A
G
L
K
Q
R
V
H
A
I
L
D
K
----
H
----
G
V
--
Q
Y
D
L
Q
W
S
C
-
S
G
Q
P
F
-
L
T
Q
A
-
G
-
K
-
L
T
D
------
V
A
R
A
A
I
A
E
T
C
-
G
I
E
-
A
-
E
L
S
T
T
G
G
T
S
D
-
G
R
F
I
K
-
A
----
I
--
A
Q
E
L
--
I
-
E
L
G
P
S
N
-
A
-
T
I
H
Q
-
I
N
E
N
V
R
L
N
D
I
P
K
L
S
A
V
Y
E
G
I
L
-----
18
PsiBlast_PDB
44.72
22%
35
- C1 -
1VGY
-
DAPE_NEIMB
A:
[2-372]
--
T
E
T
Q
S
L
E
L
A
K
E
L
I
S
R
P
S
V
T
P
----------
D
----------
D
---
R
D
C
Q
K
L
M
--
A
E
R
L
H
K
I
---
G
F
A
-
A
---
E
E
M
H
--------------------
F
G
N
T
K
N
I
W
L
R
R
G
T
---
K
---
A
P
--
V
--
V
C
F
A
G
H
T
D
-
V
--
V
P
T
G
-----
P
-
V
----
E
KWDSPPF
E
P
A
---
E
-----
R
-------------------
D
G
R
-------------------------------
L
Y
G
R
------
G
----
A
A
D
M
K
T
S
I
A
C
F
V
T
A
C
----
E
R
F
-
V
A
K
H
--
P
-
N
H
Q
G
S
I
A
L
L
I
T
S
D
E
E
------
G
D
A
L
D
G
T
--
T
---
K
-
V
V
D
V
L
K
A
R
D
E
-----
L
---
I
---
D
Y
C
I
V
G
E
------------------
P
T
AVDKLGD
M
I
K
N
G
R
R
G
S
L
S
--
G
-
N
L
T
V
K
G
K
Q
G
HIAY
P
-
H
L
A
I
-
N
P
V
H
T
F
A
P
A
L
L
E
L
T
Q
E
V
------
W
----------------------------------------------------
D
---------------
E
GNEYFP---
P
T
S
F
Q
I
S
N
I
---------
N
G
G
----
T
G-----------------------------------------------------------------------------------------------
A
T
N
V
I
--
P
G
E
L
N
V
K
F
N
F
R
-
F
S
T
E
S
T
E
A
G
L
K
Q
R
V
H
A
I
L
D
K
----
H
----
G
V
--
Q
Y
D
L
Q
W
S
C
-
S
G
Q
P
F
-
L
T
Q
A
-
G
-
K
-
L
T
D
------
V
A
R
A
A
I
A
E
T
C
-
G
I
E
-
A
-
E
L
S
T
T
G
G
T
S
D
-
G
R
F
I
K
-
A
----
M
--
A
Q
E
L
--
I
-
E
L
G
P
S
N
-
A
-
T
I
H
Q
-
I
N
E
N
V
R
L
N
D
I
P
K
L
S
A
V
Y
E
G
I
L
-----
60
HHSearch
44.70
21%
10
- C1 -
1YSJ
2
YXEP_BACSU
A:
[30-400]
--
F
H
T
R
L
I
N
M
R
R
D
L
H
E
H
P
E
L
S
F
----------
Q
----------
E
---
V
E
T
T
K
K
I
--
R
R
W
L
E
E
E
---
Q
I
E
-
I
---
L
D
V
P
--------------------
Q
L
K
T
G
V
I
A
E
I
K
G
R
---
E
-
D
-
G
P
--
V
--
I
A
I
R
A
D
I
D
A
L
--
P
I
Q
E
-----
Q
T
N
----
L
--------
P
F
---
A
SK---
V
-------------------
D
G
T
-------------------------------
M
H
A
C
------
G
H
----
D
F
H
T
A
S
I
I
G
T
A
M
L
L
----
N
Q
R
-
R
A
----
E
-
L
K
-
G
T
V
R
F
I
F
Q
P
A
E
E
I
A
--
A
G
A
R
K
V
L
E
A
--
G
V--
L
-
N
G
V
S
A
I
F
G
M
H
N
K
PDL
P
---
V
---
G
T
I
G
V
K
E
G
PL
M
--------------
A
S
---------
V
D
R
F
E
I
V
I
K
--
G
-
K
---------------
N
S
I
-
D
P
I
A
A
A
G
Q
I
I
S
G
----------------------------------------------------------------
L
---------------
Q
---------
N
A
V
V
S
I
T
R
V
---------
Q
A
G
----
T
------------------------------------------------------------------------------------------------
S
W
N
V
I
--
P
D
Q
A
E
M
E
G
T
V
R
T
F
Q
K
E
A
R
Q
A
V
P
-
E
H
M
R
R
V
A
E
G
I
A
A
G
Y
----
G
A
--
Q
A
E
F
K
W
F
P
-
Y
L
P
S
V
---
Q
N
-
D
G
T
-
F
L
N
------
A
A
S
E
A
A
A
R
-
L
-
G
Y
Q
-
T
V
H
A
E
Q
S
P
G
G
E
D
-
F
A
L
Y
Q
-
E
-------
K
I
P
G
F
F
V
-
W
M
G
T
N
G
T
E
-
E
W
H
H
-
P
A
F
T
L
D
E
E
A
L
T
V
A
S
Q
Y
F
A
E
L
A
V
I
V
L
-
15
PsiBlast_PDB
44.64
23%
34
- C1 -
4O23
3
DAPE_NEIMB
A:
[5-375]
--
T
E
T
Q
S
L
E
L
A
K
E
L
I
S
R
P
S
V
T
P
----------
D
----------
D
---
R
D
C
Q
K
L
L
--
A
E
R
L
H
K
I
---
G
F
A
-
A
---
E
E
L
H
F
G
D
------
T
--------
K
N
------
I
W
L
R
R
G
T
---
K
---
A
P
--
V
--
V
C
F
A
G
H
T
D
-
V
--
V
P
T
G
-----
P
-
V
----
E
KWDSPPFE
P
A
---
E
-----
R
-------------------
D
G
R
-------------------------------
L
Y
G
R
------
G
----
A
A
D
M
K
T
S
I
A
C
F
V
T
A
C
----
E
R
F
-
V
A
K
H
--
P
-
N
H
Q
G
S
I
A
L
L
I
T
S
D
E
E
------
G
D
A
L
D
G
T
--
T
---
K
-
V
V
D
V
L
K
A
R
D
E
-----
L
---
I
---
D
Y
C
I
V
G
E
------------------
P
T
AVDKLGD
M
I
K
N
G
R
R
G
S
L
S
--
G
-
N
L
T
V
K
G
K
Q
G
HIAY
P
-
H
L
A
I
-
N
P
V
H
T
F
A
P
A
L
L
E
L
T
Q
E
V
------
W
----------------------------------------------------
D
---------------
E
GNEYFP---
P
T
S
F
Q
I
S
N
I
---------
N
G
G
----
T
G-----------------------------------------------------------------------------------------------
A
T
N
V
I
--
P
G
E
L
N
V
K
F
N
F
R
-
F
S
T
E
S
T
E
A
G
L
K
Q
R
V
H
A
I
L
D
K
----
H
----
G
V
--
Q
Y
D
L
Q
W
S
C
-
S
G
Q
P
F
-
L
T
Q
A
-
G
-
K
-
L
T
D
------
V
A
R
A
A
I
A
E
T
C
-
G
I
E
-
A
-
E
L
S
T
T
G
G
T
S
D
-
G
R
F
I
K
-
A
----
I
--
A
Q
E
L
--
I
-
E
L
G
P
S
N
-
A
-
T
I
H
Q
-
I
N
E
N
V
R
L
N
D
I
P
K
L
S
A
V
Y
E
G
I
L
-----
4
PsiBlast_PDB
44.42
26%
33
- C1 -
1FNO
4
PEPT_SALTY
A:
[3-406]
-----
K
L
L
E
R
F
L
H
Y
V
S
L
D
T
Q
S
K
----------
S
----------
G
---
V
R
Q
V
P
S
T
--
E
G
Q
W
K
L
L
---
R
L
L
-
K
Q
Q
L
E
E
M
G
L
V
N
------
I
--------
T
L
S
E
K
G
T
L
M
A
T
L
P
A
N
---
V
-
E
-
G
D
I
P
A
--
I
G
F
I
S
H
V
D
T
S
PD
F
S
G
K
-----
N
-
V
----
N
--------
P
Q
---
I
-----
V
-------------------
E
N
Y
RG
G
D
I
A
L
G
IGDEVLSPVMFP
V
L
H
Q
L
LG
Q
T
L
-
I
T
T
D
------
G
K
T
L
L
G
A
D
D
K
A
G
V
A
E
I
M
T
A
L
----
A
V
L
-
K
G
N
P
--
I
-
P
H
-
G
D
I
K
V
A
F
T
P
D
E
E
V
G
K
--
G
A
K
H
F
D
V
E
--
A
---
F
-
G
A
Q
W
A
Y
T
V
D
G
G
G
-------
V
---
G
E
L
E
F
E
N
------------------
F
N
---------
A
A
S
V
N
I
K
I
V
--
G
-
N
N
V
H
P
G
T
A
-----
K
-
G
V
M
V
-
N
A
L
S
L
A
A
R
I
H
A
E
V
P
A
D
E
------
A
----------------------------------------------------
P
---------------
E
---------
T
T
E
G
Y
E
G
F
Y
---------
H
L
A
----
S
------------------------------------------------------------------------------------------------
M
K
G
T
V
--
D
R
-----
A
E
M
H
Y
I
I
R
D
F
D
R
K
Q
F
-
E
A
R
K
R
K
M
M
E
I
A
K
K
V
----
G
K
GL
H
P
D
C
Y
I
E
L
-
V
I
E
D
S
-
Y
Y
N
M
-
R
E
K
-
V
V
E
HPHI
L
D
I
A
Q
Q
A
M
R
D
-
C
-
H
I
T
-
P
-
E
M
K
P
I
R
G
G
T
D
-
G
A
Q
L
S
-
F
----
M
--
G
L
P
C
--
P
-
N
L
F
T
G
G
-
Y
-
N
Y
H
G
-
K
H
E
F
V
T
L
E
G
M
E
K
A
V
Q
V
I
V
R
I
A
E
L
T
A
K
54
HHSearch
44.34
21%
-9
- C1 -
4Q7A
3
?
A:
[11-359]
--
M
S
M
T
T
A
D
L
L
R
G
L
V
S
I
P
S
P
S
G
----------
A
----------
E
---
A
P
A
V
E
W
L
--
C
Q
Q
M
A
A
L
---
G
Y
Q
-
A
---
E
P
D
G
----------------------
A
G
N
A
V
G
T
R
G
E
------
G
-
P
R
--
E
--
I
M
L
L
G
H
I
D
T
V
--
P
G
E
V
-----
P
-
V
--------------
Q
---
V
-----
V
-------------------
D
G
V
-------------------------------
L
Y
G
R
------
G
A
----
V
D
A
K
G
P
L
A
T
F
V
V
A
G
----
A
R
A
-
K
L
----
P
-
P
G
-
V
R
L
T
V
V
G
A
V
E
E
E
V
M
S
S
R
G
A
R
H
L
I
A
T
--
R
---
E
-
A
P
D
A
V
V
I
G
E
P
S
G
-------
W
---
D
G
V
V
L
G
Y
------------------
R
G
---------
S
V
A
L
E
Y
R
V
T
--
V
-
P
M
S
H
S
A
-
G
-----
P
-
E
A
---
T
A
A
E
L
A
A
D
F
W
Y
R
L
R
T
W
C
------
A
----------------------------------------------------
E
W
S
-------------
V
GIDHAFH
R
V
E
P
K
L
N
A
-------------
L
N
----
S
------------------------------------------------------------------------------------------------
S
S
D
G
L
--
Y
G
E
A
V
A
R
I
G
L
R
L
P
P
A
L
S
P
E
E
A
I
-
A
V
A
T
S
L
A
S
E
G
------------
E
V
T
A
T
--
V
-
N
A
P
A
F
-
Q
T
D
K
-
R
Q
P
-
I
V
A
------
A
F
L
A
A
V
R
A
-
H
-
G
G
T
-
P
-
R
L
K
L
K
T
G
T
S
D
-
M
N
L
V
G
P
A
----
W
--
G
C
P
I
--
V
-
A
Y
G
P
G
D
S
R
-
L
D
H
T
-
P
E
E
H
V
P
L
A
D
L
E
R
A
T
A
I
L
T
T
A
I
E
R
V
A
A
55
HHSearch
43.05
17%
6
- C1 -
3PFE
24
?
A:
[18-470]
----
E
E
I
L
P
S
L
C
D
Y
I
K
I
P
N
K
S
P
----------
H
FDAKWEEHG
Y
M
---
E
Q
A
V
N
H
I
--
A
N
W
C
K
S
H
APK
G
M
T
-
L
---
E
I
V
R
L
K
------------------
N
R
T
P
L
L
F
M
E
I
P
G
Q
-----
I
-
D
D
--
T
--
V
L
L
Y
G
H
L
D
K
Q
--
P
E
M
S
-----
G
-
W
SDDL
H
--------
P
W
K
P
V
L
-----
K
-------------------
N
G
L
-------------------------------
L
Y
G
R
------
G
G
----
A
D
D
G
Y
S
A
Y
A
S
L
T
A
I
----
R
A
L
-
E
Q
Q
G
--
L
-
P
Y
-
P
R
C
I
L
I
I
E
A
C
E
E
S
G
S
-
Y
D
L
P
F
Y
I
E
L
--
L
KER
I
G
K
P
S
L
V
I
C
L
D
S
G
A
---
G
---
N
YE
Q
L
W
M
T
T
S
L
------------------
R
G
---------
N
L
V
G
K
L
T
V
E
LI
N
-
E
G
V
H
S
G
-
S
-----
A
S
G
I
V
A
-
D
S
F
R
V
A
R
Q
L
I
S
R
I
E
D
E
N
TGE---
I
KLPQLYCDIP
D
E
R
I
K
Q
A
K
Q
C
A
E
I
L
GEQVYSEFPWIDSAKPVIQD
K
Q
Q
L
I
L
N
R
T
---------------
W
---------
R
P
A
L
T
V
T
G
A
---------
D
G
F
PAIA
D
------------------------------------------------------------------------------------------------
A
G
N
V
M
--
R
P
V
T
S
L
K
L
S
M
R
L
P
P
L
V
D
P
E
A
A
S
-
V
A
M
E
K
A
L
T
Q
N
P
P
-
Y
----
N
A
--
K
V
D
F
K
I
Q
N
G
G
S
K
G
W
-
N
A
P
L
-
L
S
D
W
L
A
K
------
A
A
S
E
A
S
M
T
Y
Y
-
D
K
P
-
A
-
A
Y
M
G
E
G
G
T
I
P
F
M
S
M
L
G
-
E
Q
F
PK
A
Q-
F
M
I
T
--
G
-
V
L
G
P
H
S
---
N
A
H
G
-
P
N
E
F
L
H
L
D
M
V
K
K
L
T
S
C
V
S
Y
V
L
Y
S
F
S
Q