@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24090: (2016-07-08 )
MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFLLTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLLKAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVAHAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQIAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSRADSAENKLYSIALAICASEEYTH
Atome Classification :
(20 SA)
.........10........20.....---....30-.......-.40-.--........50-----...--------------......60..--......70--.--------------------------.---------------------------.....--------..80...----..-----...90.....-.-..-100-..---.....110----------------------.-.-.....120......----.----130........140........150.......160.-.......170.......180---.-....---..190.......200.......210.......220.......230.......240.......250-......-----------------------------.-.-.-260-...-....270.......280.......290.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
L
K
D
L
IGKASIHKN
K
T
I
A
V
-AHAE
D
---
E
E
V
I
R
A
-
V
K
L
A
A
E
H-L
S
--
A
--
R
F
L
LTGD
S
K
------
K
L
N
--------------
E
L
T
S
SMQG
H
Q
--
V
E
I
V
HAN---T--------------------------P---------------------------
E
E
S
A
K
--------
L
A
V
R
A
V
H----HK-----
T
A
D
V
LMKGNV-
P
-
T
S
-
V
L
L
-
K
A
---
V
L
N
R
Q
EG
L
----------------------
R
-
S
-
A
S
V
L
S
H
V
A
V
FDIPD----F----D-
R
L
M
F
V
TDSAM-NIAP
S
L
E
E
L
R
Q
I
L
Q
N
A
V
H
V
A
H
-
A
-VGNNM
P
K
A
A
A
L
A
A
VETVNP
K
---
M
-
E
A
T
V
---
N
A
A
A
L
A
Q
M
Y
KRGQ
I
K
G
C
IVDG
P
L
A
L
D
N
A
V
S
Q
I
A
A
A
Q
K
KISGDVAGNA
D
I
L
L
V
P
TIEA
G
N
I
L
Y
K
---
S
L
I
Y
F
A
-----------------------------
K
-
A
-
S
-
V
A
A
-
V
IT-GAKA
P
I
A
L
TSRADSAEN
K
L
Y
S
I
A
L
A
I
CASEEYTH
1
PsiBlast_PDB
94.96
44%
-127
- C3 -
3TNG
7
?
A:
[21-286]
-----------------
F
A
V
-
A
G
A
D
D
---
E
V
V
L
E
T
-
I
R
L
A
L
K
Q
-
K
L
--
G
--
K
F
L
L
F
G
-
K
K
------
E
D
K
--------------
T
L
T
A
N
---
E
S
--
V
T
W
I
Q
T
D
---
T
--------------------------
A
---------------------------
E
A
A
A
Q
--------
G
A
I
L
A
V
K
----
N
K
-----
E
A
D
I
L
V
K
G
F
I
-
P
-
T
A
-
T
L
M
-
H
H
---
V
L
K
K
E
N
G
L
----------------------
R
-
T
-
D
Q
L
L
S
Q
I
A
I
F
D
I
P
T
----
Y
----
H
-
K
P
L
L
I
T
D
C
A
M
-
N
V
A
P
K
T
K
E
K
I
A
I
T
E
N
A
L
A
V
A
H
-
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
V
E
E
V
T
A
K
---
M
-
P
S
T
L
---
E
A
Q
E
V
V
Q
H
F
G
N
-
Q
I
S
---
V
S
G
P
L
A
L
D
V
A
I
S
K
E
A
A
L
H
K
G
I
T
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
E
T
G
N
A
L
Y
K
---
S
L
V
Y
F
A
-----------------------------
G
-
A
-
K
-
V
G
S
-
A
V
V
-
G
A
K
V
P
I
V
I
S
S
R
N
D
S
P
E
N
K
L
A
S
F
I
L
T
V
--------
2
PsiBlast_PDB
94.42
44%
-128
- C3 -
3U9E
13
?
A:
[21-286]
-----------------
F
A
V
-
A
G
A
D
D
---
E
V
V
L
E
T
-
I
R
L
A
L
K
Q
-
K
L
--
G
--
K
F
L
L
F
G
-
K
K
------
E
D
K
--------------
T
L
T
A
N
---
E
S
--
V
T
W
I
Q
T
D
---
T
--------------------------
A
---------------------------
E
A
A
A
Q
--------
G
A
I
L
A
V
K
----
N
K
-----
E
A
D
I
L
V
K
G
F
I
-
P
-
T
A
-
T
L
M
-
H
H
---
V
L
K
K
E
N
G
L
----------------------
R
-
T
-
D
Q
L
L
S
Q
I
A
I
F
D
I
P
T
----
Y
----
H
-
K
P
L
L
I
T
D
C
A
M
-
N
V
A
P
K
T
K
E
K
I
A
I
T
E
N
A
L
A
V
A
H
-
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
V
E
E
V
T
A
K
---
M
-
P
S
T
L
---
E
A
Q
E
V
V
Q
H
F
G
N
-
Q
I
S
---
V
S
G
P
L
A
L
D
V
A
I
S
K
E
A
A
L
H
K
G
I
T
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
E
T
G
N
A
L
Y
K
---
S
L
V
Y
F
A
-----------------------------
G
-
A
-
K
-
V
G
S
-
A
V
V
-
G
A
K
V
P
I
V
I
S
S
R
N
D
S
P
E
N
K
L
A
S
F
I
L
T
V
--------
3
PsiBlast_PDB
93.94
44%
-128
- C3 -
3UF6
1
?
A:
[21-286]
-----------------
F
A
V
-
A
G
A
D
D
---
E
V
V
L
E
T
-
I
R
L
A
L
K
Q
-
K
L
--
G
--
K
F
L
L
F
G
-
K
K
------
E
D
K
--------------
T
L
T
A
N
---
E
S
--
V
T
W
I
Q
T
D
---
T
--------------------------
A
---------------------------
E
A
A
A
Q
--------
G
A
I
L
A
V
K
----
N
K
-----
E
A
D
I
L
V
K
G
F
I
-
P
-
T
A
-
T
L
M
-
H
H
---
V
L
K
K
E
N
G
L
----------------------
R
-
T
-
D
Q
L
L
S
Q
I
A
I
F
D
I
P
T
----
Y
----
H
-
K
P
L
L
I
T
D
C
A
M
-
N
V
A
P
K
T
K
E
K
I
A
I
T
E
N
A
L
A
V
A
H
-
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
V
E
E
V
T
A
K
---
M
-
P
S
T
L
---
E
A
Q
E
V
V
Q
H
F
G
N
-
Q
I
S
---
V
S
G
P
L
A
L
D
V
A
I
S
K
E
A
A
L
H
K
G
I
T
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
E
T
G
N
A
L
Y
K
---
S
L
V
Y
F
A
-----------------------------
G
-
A
-
K
-
V
G
S
-
A
V
V
-
G
A
K
V
P
I
V
I
S
S
R
N
D
S
P
E
N
K
L
A
S
F
I
L
T
V
--------
18
HHSearch
93.79
43%
-122
- C3 -
3UF6
1
?
A:
[16-290]
------------
T
S
S
F
V
F
A
V
-
A
G
A
D
D
---
E
V
V
L
E
T
-
I
R
L
A
L
K
Q
-
K
L
--
G
--
K
F
L
L
F
G
K
K
E
------
D
K
T
--------------
L
T
A
N
-
E
S
-----
V
T
W
I
Q
T
D
---
T
--------------------------
A
---------------------------
E
A
A
A
Q
--------
G
A
I
L
A
V
K
----
N
K
-----
E
A
D
I
L
V
K
G
F
I
-
P
-
T
A
-
T
L
M
-
H
H
---
V
L
K
K
E
N
G
L
----------------------
R
-
T
-
D
Q
L
L
S
Q
I
A
I
F
D
I
P
T
----
Y
----
H
-
K
P
L
L
I
T
D
C
A
M
-
N
V
A
P
K
T
K
E
K
I
A
I
T
E
N
A
L
A
V
A
H
-
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
V
E
E
V
T
A
K
---
M
-
P
S
T
L
---
E
A
Q
E
V
V
Q
H
F
G
----
N
Q
I
S
V
S
G
P
L
A
L
D
V
A
I
S
K
E
A
A
L
H
K
G
I
T
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
E
T
G
N
A
L
Y
K
---
S
L
V
Y
F
A
-----------------------------
G
-
A
-
K
-
V
G
S
-
A
V
V
-
G
A
K
V
P
I
V
I
S
S
R
N
D
S
P
E
N
K
L
A
S
F
I
L
T
V
R
L
V
E
----
36
Fugue
88.97
40%
-64
* C3 *
3TNG
7
?
A:
[5-291]
-
T
K
S
R
F
F
S
D
V
A
E
T
S
S
F
V
F
A
V
-
A
G
A
D
D
---
E
V
V
L
E
T
-
I
R
L
A
L
K
Q
-
K
L
--
G
--
K
F
L
L
F
G
K
K
E
------
D
K
T
--------------
L
T
A
N
E
----
S
--
V
T
W
I
Q
T
D
---
T
--------------------------
A
---------------------------
E
A
A
A
Q
--------
G
A
I
L
A
V
K
----
N
K
-----
E
A
D
I
L
V
K
G
F
I
-
P
-
T
A
-
T
L
-
M
H
H
---
V
L
K
K
E
N
G
L
----------------------
R
-
T
-
D
Q
L
L
S
Q
I
A
I
F
D
I
P
T
----
Y
----
H
-
K
P
L
L
I
T
D
C
A
-M
N
V
A
P
K
T
K
E
K
I
A
I
T
E
N
A
L
A
V
A
H
-
Q
-
I
G
I
T
N
P
K
I
A
L
L
S
A
V
E
E
V
T
A
----
K
M
P
S
T
L
---
E
A
Q
E
V
V
Q
H
F
G
N
Q
----
I
S
V
S
G
P
L
A
L
D
V
A
I
S
K
E
A
A
L
H
K
G
I
T
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
E
T
G
N
A
L
Y
K
---
S
L
V
Y
F
A
-----------------------------
G
-
A
-
K
-
V
G
S
-
A
V
V
-
G
A
K
V
P
I
V
I
S
S
R
N
D
S
P
E
N
K
L
A
S
F
I
L
T
V
R
L
V
E
K
---
21
HHSearch
81.30
38%
-39
- C3 -
1YCO
1
?
A:
[1-276]
--------------
M
I
T
V
S
I
-
A
G
G
S
Q
---
P
E
I
L
Q
L
-
V
K
K
A
L
K
E
-
A
E
Q
P
L
--
Q
F
I
V
F
D
T
N
E
------
N
L
D
--------------
T
---
E
N
L
-----
W
K
Y
V
H
C
S
---
D
--------------------------
E
---------------------------
A
A
V
A
Q
--------
E
A
V
S
L
V
A
----
T
G
-----
Q
A
Q
I
L
L
K
G
I
I
-
Q
-
T
H
-
T
L
L
-
K
E
---
M
L
K
S
E
H
Q
L
----------------------
K
-
N
-
K
P
I
L
S
H
V
A
M
V
E
L
P
A
---------
G
-
K
T
F
L
L
T
D
C
A
M
-
N
I
A
P
T
Q
A
T
L
I
E
I
V
E
N
A
K
E
V
A
Q
-
K
-
L
G
L
H
H
P
K
I
A
L
L
S
A
A
E
N
F
N
P
K
---
M
-
P
S
S
V
---
L
A
K
E
V
T
A
H
F
N
D
--
Q
Q
E
A
T
V
F
G
P
L
S
L
D
L
A
T
S
E
E
A
V
A
H
K
R
Y
S
G
P
I
M
G
D
A
D
I
L
V
V
P
T
I
D
V
G
N
C
L
Y
K
---
S
L
T
L
F
G
-----------------------------
H
-
A
-
K
-
V
G
G
-
T
I
V
-
G
T
K
V
P
V
V
L
T
S
R
S
D
S
T
E
S
K
F
H
S
L
R
F
A
M
R
Q
V
H
H
H
--
4
PsiBlast_PDB
79.26
37%
-40
- C3 -
1YCO
1
?
A:
[3-270]
----------------
T
V
S
I
-
A
G
G
S
Q
---
P
E
I
L
Q
L
-
V
K
K
A
L
K
E
-
A
E
--
Q
P
L
Q
F
I
V
F
D
T
N
E
------
N
L
D
----------------
T
E
N
L
W
K
Y
------
V
H
C
S
---
D
--------------------------
E
---------------------------
A
A
V
A
Q
--------
E
A
V
S
L
V
A
----
T
G
-----
Q
A
Q
I
L
L
K
G
I
I
-
Q
-
T
H
-
T
L
L
-
K
E
---
M
L
K
S
E
H
Q
L
----------------------
K
-
N
-
K
P
I
L
S
H
V
A
M
V
E
L
P
A
---------
G
-
K
T
F
L
L
T
D
C
A
M
-
N
I
A
P
T
Q
A
T
L
I
E
I
V
E
N
A
K
E
V
A
Q
-
K
-
L
G
L
H
H
P
K
I
A
L
L
S
A
A
E
N
F
N
P
K
---
M
-
P
S
S
V
---
L
A
K
E
V
T
A
H
F
N
D
Q
Q
--
E
A
T
V
F
G
P
L
S
L
D
L
A
T
S
E
E
A
V
A
H
K
R
Y
S
G
P
I
M
G
D
A
D
I
L
V
V
P
T
I
D
V
G
N
C
L
Y
K
---
S
L
T
L
F
G
-----------------------------
H
-
A
-
K
-
V
G
G
-
T
I
V
-
G
T
K
V
P
V
V
L
T
S
R
S
D
S
T
E
S
K
F
H
S
L
R
F
A
M
--------
23
HHSearch
71.72
24%
-24
- C3 -
2AF4
2
PTAS_METTE
C:
[5-331]
--
L
E
K
I
S
E
R
A
K
-
K
L
N
K
T
I
A
L
-
P
E
T
E
D
---
I
R
T
L
Q
A
-
A
A
K
I
L
E
R
-
G
I
--
A
--
D
I
V
L
V
G
N
E
A
------
D
I
K
--------------
A
L
A
G
D
L
D
L
S
K
--
A
K
I
V
D
P
K
T--
Y
--------------------------
E
KKDEYINAFYELRKHKGITLENAAEIM
S
D
Y
V
Y
--------
F
A
V
M
M
A
K
----
L
G
-----
E
V
D
G
V
V
S
G
A
A
-
H
-
S
S
S
D
T
L
-
R
P
---
A
V
Q
I
-
V
K
T
----------------------
A
K
G
-
A
A
L
A
S
A
F
F
I
I
S
V
P
D
CEYG
S
----
D
-
G
T
F
L
F
A
D
S
G
M
-
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
-
L
-
L
V
Q
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
---
S
-
K
L
T
E
---
A
T
I
A
S
T
K
L
A
Q
E
-
L
A
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
---
I
A
Q
R
L
A
-----------------------------
K
-
A
-
E
-
A
Y
G
P
I
T
Q
-
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
A
A
Q
--
7
PsiBlast_PDB
71.61
25%
-36
- C3 -
2AF4
2
PTAS_METTE
C:
[16-323]
--------------
N
K
T
I
A
L
-
P
E
T
E
D
---
I
R
T
L
Q
A
-
A
A
K
I
L
E
R
-
G
I
--
A
--
D
I
V
L
V
G
N
E
A
------
D
I
K
--------------
A
L
A
G
D
L
D
L
S
K
--
A
K
I
V
D
P
K
---
T
--------------------------
Y
---------------------------
E
K
K
D
E
--------
Y
-
I
N
A
F
Y
ELRK
H
K
GITLE
N
A
A
E
I
M
S
D
Y
V
-
Y
-
F
A
-
V
M
M
--
A
---
K
L
G
E
V
D
G
V
VSGAAHSSSDTLRPAVQIVKTA
K
-
G
-
A
A
L
A
S
A
F
F
I
I
S
V
P
D
----
C
EYGS
D
-
G
T
F
L
F
A
D
S
G
M
-
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
-
L
-
L
V
Q
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
SKL
T
-
E
A
T
I
---
A
S
T
K
L
A
Q
E
L
A
----
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
---
I
A
Q
R
L
A
-----------------------------
K
-
A
-
E
-
A
Y
G
-
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
----------
6
PsiBlast_PDB
71.10
25%
-38
- C3 -
2AF3
3
PTAS_METTE
C:
[16-323]
--------------
N
K
T
I
A
L
-
P
E
T
E
D
---
I
R
T
L
Q
A
-
A
A
K
I
L
E
R
-
G
I
--
A
--
D
I
V
L
V
G
N
E
A
------
D
I
K
--------------
A
L
A
G
D
L
D
L
S
K
--
A
K
I
V
D
P
K
---
T
--------------------------
Y
---------------------------
E
K
K
D
E
--------
Y
-
I
N
A
F
Y
ELRK
H
K
GITLE
N
A
A
E
I
M
S
D
Y
V
-
Y
-
F
A
-
V
M
M
--
A
---
K
L
G
E
V
D
G
V
VSGAAHSSSDTLRPAVQIVKTA
K
-
G
-
A
A
L
A
S
A
F
F
I
I
S
V
P
D
----
C
EYGS
D
-
G
T
F
L
F
A
D
S
G
M
-
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
-
L
-
L
V
Q
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
SKL
T
-
E
A
T
I
---
A
S
T
K
L
A
Q
E
L
A
----
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
---
I
A
Q
R
L
A
-----------------------------
K
-
A
-
E
-
A
Y
G
-
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
----------
5
PsiBlast_PDB
69.73
25%
-40
- C3 -
1QZT
5
PTAS_METTE
A:
[16-323]
--------------
N
K
T
I
A
L
-
P
E
T
E
D
---
I
R
T
L
Q
A
-
A
A
K
I
L
E
R
-
G
I
--
A
--
D
I
V
L
V
G
N
E
A
------
D
I
K
--------------
A
L
A
G
D
L
D
L
S
K
--
A
K
I
V
D
P
K
---
T
--------------------------
Y
---------------------------
E
K
K
D
E
--------
Y
-
I
N
A
F
Y
E
L
R
K
H
K
GIT
L
E
N
A
A
E
I
M
S
D
Y
V
-
Y
-
F
A
-
V
M
M
--
A
---
K
L
G
E
V
D
G
V
V
S
GAAHS
S
S
D
T
L
R
P
A
V
Q
IVKTA
K
-
G
-
A
A
L
A
S
A
F
F
I
I
S
V
P
D
----
C
EYGS
D
-
G
T
F
L
F
A
D
S
G
M
-
V
E
M
P
S
V
E
D
V
A
N
I
A
V
I
S
A
K
T
F
E
-
L
-
L
V
Q
D
V
P
K
V
A
M
L
S
Y
S
T
K
G
S
A
K
S
K
L
T
-
E
A
T
I
---
A
S
T
K
L
A
Q
E
L
A
----
P
D
I
A
I
D
G
E
L
Q
V
D
A
A
I
V
P
K
V
A
A
S
K
A
P
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
N
C
G
N
I
A
Y
K
---
I
A
Q
R
L
A
-----------------------------
K
-
A
-
E
-
A
Y
G
-
P
I
T
Q
G
L
A
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
----------
20
HHSearch
68.66
22%
-52
- C3 -
1VMI
2
EUTD_ECOLI
A:
[14-335]
-
I
I
E
R
C
R
E
L
A
-
L
R
A
P
A
R
V
V
F
-
P
D
A
L
D
---
Q
R
V
L
K
A
-
A
Q
Y
L
H
Q
Q
-
G
L
--
A
--
T
P
I
L
V
A
N
P
F
------
E
L
R
--------------
Q
F
A
L
S
H
G
V
A
M
DG
L
Q
V
I
D
P
H
G--
N
L
A
M
R
E
E
F
A
H
R
W
L
A
R
AGEKT-------
P
PD
A
L
E
K
L
--------------------
T
D
P
L
M
--------
F
A
A
A
M
V
S
----
A
G
-----
K
A
D
V
C
I
A
G
N
L
-
S
S
T
A
-
N
V
L
-
R
A
---
G
L
R
I
-
I
G
L
----------------------
Q
-
P
G
C
K
T
L
S
S
I
F
L
M
-
L
P
Q
----
Y
S
---
G
-
P
A
L
G
F
A
D
C
S
V
-
V
P
Q
P
T
A
A
Q
L
A
D
I
A
L
A
S
A
E
T
W
R
-
A
I
T
G
E
-
E
P
R
V
A
M
L
S
F
S
S
N
G
S
A
R
---
H
-
P
C
V
A
---
N
V
Q
Q
A
T
E
I
V
R
E
-
R
A
P
K
L
V
V
D
G
E
L
Q
F
D
A
A
F
V
P
E
V
A
A
Q
K
A
P
A
S
P
L
Q
G
K
A
N
V
M
V
F
P
S
L
E
A
G
N
I
G
Y
K
---
I
A
Q
R
L
G
-----------------------------
G
-
Y
-
R
A
V
G
P
-
L
I
Q
-
G
L
A
A
P
M
H
D
L
S
R
G
C
S
V
Q
E
I
I
E
L
A
L
V
A
A
V
P
R
-----
24
HHSearch
67.33
23%
-12
- C3 -
4E4R
9
PTAS_STAAR
A:
[7-330]
-
L
L
N
V
L
K
D
K
L
-
S
G
K
N
V
K
I
V
L
-
P
E
G
E
D
---
E
R
V
L
T
A
-
A
T
Q
L
Q
A
T
-
D
Y
--
V
--
T
P
I
V
L
G
D
E
T
------
K
V
Q
--------------
S
L
A
Q
K
L
N
L
D
I
SN
I
E
L
I
N
P
A
T--
S
--------------------------
E
L
K
A
E
L
V
Q
S
F
V
E
R
R
K
GKTT
E
E
Q
A
Q
E
L
L
-
N
N
V
N
Y
--------
F
G
T
M
L
V
Y
----
A
G
-----
K
A
D
G
L
V
S
G
A
A
-
H
-
S
T
G
D
T
V
-
R
P
---
A
L
Q
I
-
I
K
T
----------------------
K
P
G
-
V
S
R
T
S
G
I
F
F
M
I
K
G
----------
D
-
E
Q
Y
I
F
G
D
C
A
I
-
N
P
E
L
D
S
Q
G
L
A
E
I
A
V
E
S
A
K
S
A
L
-
S
-
F
G
M
-
D
P
K
V
A
M
L
S
F
S
T
K
G
S
A
K
S
D
D
V
-
T
K
V
Q
---
E
A
V
K
L
A
Q
Q
K
A
E
E
E
K
L
E
A
I
I
D
G
E
F
Q
F
D
A
A
I
V
P
G
V
A
E
K
K
A
P
G
A
K
L
Q
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
---
I
A
Q
R
L
G
-----------------------------
G
-
Y
D
A
-
V
G
P
-
V
L
Q
-
G
L
N
S
P
V
N
D
L
S
R
G
C
S
I
E
D
V
Y
N
L
S
F
I
T
A
A
Q
A
L
----
19
HHSearch
64.58
22%
-17
- C3 -
1R5J
-
?
A:
[7-329]
--
F
G
G
L
R
E
K
I
L
-
G
K
N
M
K
I
V
F
-
P
E
G
N
D
---
E
R
V
V
R
A
-
A
A
R
L
K
F
E
-
G
L
--
L
--
E
P
I
I
L
G
Q
S
E
------
E
V
R
--------------
N
L
L
T
K
L
G
F
A
D
QD
Y
T
I
I
N
P
N
E--
Y
--------------------------
A
DF
D
K
M
K
E
A
F
V
E
V
RKGKAT
L
E
D
A
D
K
M
L
-
R
D
V
N
Y
--------
F
G
V
M
L
V
K
----
M
G
-----
L
A
D
G
M
V
S
G
A
I
-
H
-
S
T
A
D
T
V
-
R
P
---
A
L
Q
I
-
I
K
T
----------------------
K
P
G
-
I
S
R
T
S
G
V
F
L
M
N
R
E
N
----
T
----
S
-
E
R
Y
V
F
A
D
C
A
I
-
N
I
D
P
T
A
Q
E
L
A
E
I
A
V
N
T
A
E
T
A
K
-
I
-
F
D
I
-
D
P
K
I
A
M
L
S
F
S
T
K
G
S
G
K
---
A
-
P
Q
V
D
---
K
V
R
E
A
T
E
I
A
T
G
-
L
N
P
D
L
A
L
D
G
E
L
Q
F
D
A
A
F
V
P
E
T
A
A
I
K
A
P
D
S
A
V
A
G
Q
A
N
T
F
V
F
P
D
L
Q
S
G
N
I
G
Y
K
---
I
A
Q
R
L
G
-----------------------------
M
-
F
-
D
A
I
G
P
-
I
L
Q
-
G
L
N
K
P
V
N
D
L
S
R
G
S
S
A
E
D
I
Y
K
L
A
I
I
T
A
A
Q
A
I
E
S
--
22
HHSearch
58.21
20%
0
- C- -
1TD9
6
PTAS_BACSU
A:
[10-328]
-
L
F
S
T
V
Q
E
K
V
A
-
G
K
D
V
K
I
V
F
-
P
E
G
L
D
---
E
R
I
L
E
A
-
V
S
K
L
A
G
N
-
K
V
--
L
--
N
P
I
V
I
G
N
E
N
------
E
I
Q
--------------
A
K
A
K
E
L
N
L
T
L
GG
V
K
I
Y
D
P
H
T--
Y
EG
M
E
D
L
V
Q
A
F
V
E
R
R
K
GKAT
E
E
Q
A
R
K
A
L
---------------------------
L
D
E
N
Y
--------
F
G
T
M
L
V
Y
----
K
G
-----
L
A
D
G
L
V
S
G
A
A
-
H
-
S
T
A
D
T
V
-
R
P
---
A
L
Q
I
-
I
K
T
----------------------
K
-
E
G
V
K
K
T
S
G
V
F
I
M
A
R
G
----------
E
-
E
Q
Y
V
F
A
D
C
A
I
-
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
-
M
-
F
D
I
-
E
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
---
S
-
D
E
T
E
---
K
V
A
D
A
V
K
I
A
K
E
-
K
A
P
E
L
T
L
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
---
I
A
Q
R
L
G
-----------------------------
N
-
F
-
E
A
V
G
P
-
I
L
Q
-
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
-----
12
PsiBlast_PDB
57.69
24%
6
- C3 -
4E4R
9
PTAS_STAAR
A:
[18-327]
-------------
K
N
V
K
I
V
L
-
P
E
G
E
D
---
E
R
V
L
T
A
A
T
Q
L
Q
A
T
D
-
Y
V
--
T
--
P
I
V
L
G
D
E
T
K
V
Q
S
L
A
Q
K
L
N
LDISNIELINPATS
E
L
K
A
E
L
V
Q
S
F
--
V
E
R
R
K
G
K
---
T
--------------------------
T
---------------------------
E
E
Q
A
Q
E
L
L
N
N
V
N
Y
F
G
T
M
L
V
Y
----
A
G
-----
K
A
D
G
L
V
S
G
A
A
H
S
-
T
G
-
D
T
V
-
R
P
---
A
L
Q
I
I
K
T
K
----------------------
P
-
G
-
V
S
R
T
S
G
I
-
F
F
M
I
K
G
----
D
----
E
-
Q
Y
I
F
-
G
D
C
A
I
-
N
P
E
L
D
S
Q
G
L
A
E
I
A
V
E
S
A
K
S
A
L
-
S
-
F
G
M
D
-
P
K
V
A
M
L
S
F
S
T
K
G
S
A
K
---
S
-
D
D
V
T
K
V
Q
E
A
V
K
L
A
Q
Q
K
A
E
E
E
K
L
E
A
I
I
D
G
E
F
Q
F
D
A
A
I
V
P
G
V
A
E
K
K
A
P
G
A
K
L
Q
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
---
I
A
Q
R
L
G
-----------------------------
G
-
Y
D
A
-
V
G
P
-
V
L
Q
-
G
L
N
S
P
V
N
D
L
S
R
G
C
S
I
E
D
-
V
Y
N
L
S
F
I
T
A
A
------
9
PsiBlast_PDB
55.93
26%
-69
- C3 -
1XCO
4
PTAS_BACSU
A:
[128-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
G
A
A
----
H
S
-----
T
A
D
T
V
R
-----
P
-
A
L
-
Q
I
I
-
K
T
-------
K
E
G
V
----------------------
K
-
K
-
T
S
-----
G
V
F
I
M
A
R
----
G
----
E
-
E
Q
Y
V
F
A
D
C
A
I
-
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
-
M
-
F
-
D
I
E
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
---
S
-
D
E
T
E
---
K
V
A
D
A
V
K
I
A
K
E
-
K
A
P
E
L
T
L
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
--------------------------------
E
-
A
-
V
G
P
-
I
L
Q
-
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
-
V
Y
N
L
A
L
I
T
A
A
------
25
HHSearch
53.01
19%
3
- C3 -
1VI1
-
PLSX_BACSU
A:
[1-317]
---------------
L
R
I
A
V
D
A
M
G
G
D
HA
P
K
A
V
I
D
G
-
V
I
K
G
I
E
A
F
D
D
--
L
--
H
I
T
L
V
G
D
K
T
------
T
I
E
--------------
S
H
L
T
T
T
S
-
D
R
--
I
T
V
L
H
A
D
EVI
E
PTDE----------------------
P
V
R
A
V
R
R
K
K
-------------------
N
S
S
M
V
--------
L
M
A
Q
E
V
A
----
E
N
-----
R
A
D
A
C
I
S
A
G
--
N
-
T
G
-
A
L
M
-
T
A
---
G
L
F
I
-
V
G
R
----------------------
I
K
G
-
I
D
R
P
A
L
--
A
P
T
L
P
T
----
V
S---
G
-
D
G
F
L
L
L
D
V
G
A
-
N
V
D
A
K
P
E
H
L
V
Q
Y
A
I
M
G
S
V
Y
S
Q
Q
V
-
R
G
V
T
S
P
R
V
G
L
L
N
V
G
T
E
D
K
K
G
---
N
-
E
L
T
K
---
Q
T
F
Q
I
L
K
E
-----
T
A
N
I
N
F
I
G
N
V
E
A
R
D
L
--------------
L
D
D
V
A
D
V
V
V
T
-
D
G
F
T
G
N
V
T
L
K
---
T
L
E
G
S
A
L
S
I
F
K
M
M
R
D
V
M
T
S
TLVL
K
P
K
L
K
E
M
K
M
K
M
E
Y
-
S
-
N
-
Y
G
G
A
S
L
F
-
G
L
K
A
P
V
I
K
A
H
G
S
S
D
S
N
A
V
F
R
A
I
R
Q
A
R
E
M
V
S
Q
N
--
11
PsiBlast_PDB
52.80
24%
-19
- C3 -
1VMI
2
EUTD_ECOLI
A:
[128-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
C
I
A
G
N
L
-
S
S
T
A
-
N
V
L
-
R
A
G
L
R
I
I
G
L
Q
P
G
C
----------------------
K
-
T
-
L
S
S
I
----
F
L
M
L
P
Q
----
Y
----
S
G
P
A
L
G
F
A
D
C
S
V
-
V
P
Q
P
T
A
A
Q
L
A
D
I
A
L
A
S
A
E
T
W
R
-
A
-
I
T
G
E
E
P
R
V
A
M
L
S
F
S
S
N
G
S
A
R
---
H
-
P
C
V
A
---
N
V
Q
Q
A
T
E
I
V
R
E
R
A
P
K
-
L
V
V
D
G
E
L
Q
F
D
A
A
F
V
P
E
V
A
A
Q
K
A
P
A
S
P
L
Q
G
K
A
N
V
M
V
F
P
S
L
E
A
G
N
I
G
Y
K
---
I
A
Q
R
L
G
-----------------------------
G
Y
R
-
A
-
V
G
P
-
L
I
Q
-
G
L
A
A
P
M
H
D
L
S
R
G
C
S
V
Q
E
-----------------
8
PsiBlast_PDB
51.33
26%
0
- C- -
1TD9
4
PTAS_BACSU
A:
[128-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
G
A
A
----
H
S
-----
T
A
D
T
V
R
-----
P
-
A
L
-
Q
I
I
-
K
T
-------
K
E
G
V
----------------------
K
-
K
-
T
S
-----
G
V
F
I
M
A
R
----
G
----
E
-
E
Q
Y
V
F
A
D
C
A
I
-
N
I
A
P
D
S
Q
D
L
A
E
I
A
I
E
S
A
N
T
A
K
-
M
-
F
-
D
I
E
P
R
V
A
M
L
S
F
S
T
K
G
S
A
K
---
S
-
D
E
T
E
---
K
V
A
D
A
V
K
I
A
K
E
-
K
A
P
E
L
T
L
D
G
E
F
Q
F
D
A
A
F
V
P
S
V
A
E
K
K
A
P
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
Q
R
L
G
N
F
--------------------------------
E
-
A
-
V
G
P
-
I
L
Q
-
G
L
N
M
P
V
N
D
L
S
R
G
C
N
A
E
D
-
V
Y
N
L
A
L
I
T
A
A
------