@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24580: (2016-07-09 )
MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIPEFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMIRGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPHREIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLVSLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVETVPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKEKQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFLQQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPWNPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDILTKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------.........10..--------......20........30....-----.-------...40........-50........60-........--70...-------....-------.80........90..-----......100.---.------.----....110..-.-....120..-...----------------..---130------.--.-----------.---------.----------.--------.--------------.----------140.-------.-----..---------...150.......-160---.-...-.--------------...-.170.......180-....---.--..---.---.190-.----.----..-------------.--...--------.200....-------...210-----.........220------.......----.230..---..--------------..------------------.-------------240--..--------------.---.--------------.....250--------.------------------------------------...---..--.260...--.-...270...----.-...280.......290.-----......-------------------.300-------.-------.......----------.310...--..--..320...--......330...-----.---.-..--340-----------...----....-.350---.......----..--------360--......-----.-370----.---..-----......380.......390..-.----..----.---------------------------------------.400--..----.--------.--...410.......----420--.----...---....-.430.......440..--------.....450.......460.......470.......480.......490....--...500.......510.......520--........530.......540....--...550.....------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------MNT
E
M
I
YDAK
W
P
E
--------
E
F
A
E
R
L
KNDGPWAN
W
E
L
Y
K
L
S
A
-----
E
-------
I
Q
K
T
LAIPEFEGL-RA
P
L
YLPSFTPL-
P
H
Q
L
E
V
A
Q
--
K
V
V
E
K-------MNG
K
-------
A
I
L
ADEVGLGK
T
V
E
A
-----
G
L
I
L
K
E
Y
M
I
R
---
G
------
L
----
A
K
K
I
L
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L
V
P
-
A
-
S
L
V
S
Q
W
V
K
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-
L
Q
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----------------KF---LI
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------
A
--
V
-----------
E
---------
Q
----------
K
--------
K
--------------
S
----------
Y
V
W
E
-------
Q
-----
C
D
---------
I
V
V
S
S
I
D
TAKRSP-H-----
R
-
E
I
V
-
L
--------------SI
P
-
Y
D
L
V
I
ID
E
A
H
K
L---KNSK---T--K
N
---
Y
---
E
F
---
V
----
R
----
N
L
-------------
V
--
K
K
Y
--------
C
L
L
LTA
T
P
-------
I
Q
N
R
-------
I
E
E
I
F
N
L
V
S
L
L-------KPGHLGS----
Q
N
H
F
Q
E
---
E
F
--------------
A
K
------------------
K
-------------K----SS--------------
L
---
E
--------------
A
H
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H
L
K
D
L
--------
V
------------------------------------
N
K
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---
M
I
--RNRRHDT--G-LN
W
K
Q
R
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----
T
-
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P
I
Q
FSP
S
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Q
A
L
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D
-
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-----
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R
L
K
D
S
-------------------IN---------K-------
P
A
S
M
F
S
I
----------
M
T
L
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C
--CS--S
R
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--
A
V
Y
--
M
T
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K
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M
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D
Q
K
EK-----Q---A-PA--I
D
------------
E
D
T
----
I
S
V
L
-
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-----
R
I
N
Q
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TQ----NS--------
K
A
L
--
Q
V
V
D
L
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-----
K
-K------I---DD-----
K
V
I
I
F
T
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R
A
T
Q
I
Y
L
Q
W
F
L
Q
Q-N----GI----S---------------------------------------SVPF--RG----G--------F--KRG
K
K
D
W
M
K
D
L
FR----G----
K
----
I
Q
V
---
L
I
A
T-EAGGEGI
N
L
Q
F
C
N
H
MI--------NYDLPW
N
P
M
R
L
E
Q
R
I
G
R
I
H
RLGQER
D
V
H
I
Y
NM
A
T
K
H
T
V
E
E
H
I
L
K
L
L
Y
E
K
I
H
L
--
F
E
K
V
V
G
E
L
D
D
I
L
T
K
IQVN
N
F
E
E
H
L
H
---
D
I
L
YHSAT
E
E
E
M
K
I
K
M
D
N
L
T
S
F
L
S
Y
--
K
K
QLPAEKRGS------------------------------------
68
HHSearch
75.23
29%
-2
- C1 -
3DMQ
1
RAPA_ECOLI
A:
[150-644]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
T
S
L
I
-
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Q
L
N
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A
H
--
D
V
G
R
R
-------
H
A
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L
L
A
D
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L
G
K
T
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-----
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M
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L
H
Q
Q
L
L
S
---
G
------
A
----
A
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R
V
L
I
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-
E
-
T
L
Q
H
Q
W
L
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M
L
R
----------------
R
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---
N
L
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------
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A
-----------
L
---------
F
D
D
E
R
Y
A
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A
Q
H
D
--------
A
--------------
Y
----------
N
P
F
D
-------
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-----
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Q
---------
L
V
I
C
S
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D
F
A
R
R
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K
Q
R
-----
L
-
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H
L
-
C
--------------
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A
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-
W
D
L
L
V
V
D
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---
V
W
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--
R
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---
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A
---
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----
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----
Q
L
-------------
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V
P
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L
L
L
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L
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E
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P
N
R
F
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----
F
A
Q
F
V
E
---
E
Q
--------------
K
N
------------------
Y
-------------
C
----
P
V
--------------
A
---
D
A
VAMLLAGNKLSND
E
L
N
M
L
G
E
M
--------
I
GEQDIEPLLQAANSDSEDAQSA
R
Q
E
L
V
S
M
L
MDRHGT
S
R
V
---
L
F
--
R
N
T
R
N
G
V
----
K
G
F
P
K
R
E
L
H
----
T
-
I
K
L
P
L
P
T
Q
Y
Q
T
A
I
K
-
V
S
---------
G
I
-------------------
M
-------------------
G
A
R
K
S
A
----------
E
D
R
A
R
D
M
--
L
Y
--
P
E
--------------------------------------------------
R
I
----
Y
Q
E
F
E
G
D
-----
N
A
T
W
W
N
F
----
D
P
--------
R
V
E
--
W
L
M
G
Y
L
-----
T
-
S
------
H
R--
S
Q
-----
K
V
L
V
I
C
A
K
A
A
T
A
L
Q
L
E
Q
V
L
R
E
R
E
----
G
I
----
R
---------------------------------------
A
A
V
F
--
H
E
----
G
--------
M
--
S
I
I
E
R
D
R
A
A
A
W
F
A
----
E
EDT-
G
----
A
Q
V
---
L
L
C
S
-
E
I
G
S
E
G
R
N
F
Q
F
A
S
H
M
V
--------
M
F
D
L
P
F
N
P
D
L
L
E
Q
R
I
G
R
L
D
R
I
G
Q
A
H
D
I
Q
I
H
V
P
Y
L
E
K
T
A
Q
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L
V
R
W
Y
H
E
G
L
D
A
--
F
E
H
T
C
P
T
G
R
T
I
Y
D
-----------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.62
25%
18
* C1 *
1Z3I
8
?
X:
[58-555]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
Q
R
E
G
V
K
--
F
L
W
D
C
-------
V
T
G
R
RIENSYG
C
I
M
A
D
E
M
G
L
G
K
T
L
Q
C
ITLIW
T
L
L
K
Q
S
P
D
C
K
---
P
------
E
----
I
D
K
V
I
V
V
S
P
-
S
-
S
L
V
R
N
W
Y
N
E
-
V
G
-----------------
K
W
---
L
G
G
------
R
--
V
-----------
Q
---------
P
----------
V
--------
A
IDGGSKDEIDSKLV
N
----------
F
I
S
Q
-------
Q
GMRIP
T
P
---------
I
L
I
I
S
Y
E
T
F
R
L
---
H
-----
A
-
E
V
L
-
H
--------------
K
G
K
-
V
G
L
V
I
C
D
E
G
H
R
L
---
K
N
S
D
---
N
--
Q
T
---
Y
---
L
A
---
L
----
N
----
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M
-------------
N
--
A
Q
R
--------
R
V
L
I
S
G
T
P
-------
I
Q
N
D
-------
L
L
E
Y
F
S
L
V
H
F
V
-------
N
S
G
I
L
G
T
----
A
Q
E
F
K
K
---
R
F
EIPILKGRDAD---
A
S
------------------
D
-------------
K
----
D
R
--------------
A
---
A
--------------
G
E
Q
K
L
Q
E
L
ISI-----
V
------------------------------------
N
R
C
---
L
I
--
R
-
R
T
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D
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--
L
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V
-
V
C
C
N
L
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L
Y
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L
F
-------
L
K
Q
A
------------------------------
K
-------
P
V
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L
Q
T
GKISVSSLSS
I
T
S
L
K
K
L
--
C
N
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L
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Y
-----
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C
L
T
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-----
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A
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------------
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F
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----
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N
Y
S
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T
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--
P
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----
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S
--------
G
K
M
--
L
V
L
D
Y
I
LAMTR
T
-
T
------
T
---
S
D
-----
K
V
V
L
V
S
N
Y
T
Q
T
L
D
L
F
E
K
L
C
R
N
-
R
----
R
Y
----
L
---------------------------------------
Y
V
R
L
--
D
G
----
T
--------
M
--
S
I
K
K
R
A
K
I
V
E
R
F
N
----
N
PSSP
E
----
F
I
F
---
M
L
S
S
-
K
A
G
G
C
G
L
N
L
I
G
A
N
R
L
V
--------
M
F
D
P
D
W
N
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N
D
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A
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K
K
A
L
--
S
S
C
V
V
D
E
E
Q
D
V
-------------------------------------------------------------------------------------------
55
Fugue
67.76
20%
23
- C1 -
1Z3I
10
?
X:
[1-644]
------------------------------------------------------------------------------------------------------------------------------
L
G
L
R
R
A
G
V
R
--------
K
A
L
H
D
P
F
E
D
G
A
L
V
L
Y
E
P
P
A
I
S
A
-----
H
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C
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----
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---------
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--------
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M
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L
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T
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K
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C
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----
R
Y
----
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---------------------------------------
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----
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K
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F
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P
----
E
----
F
I
F
---
M
L
S
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K
A
G
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G
L
N
L
I
G
A
N
R
L
V
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M
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D
P
D
W
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A
N
D
E
Q
A
M
A
R
V
W
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G
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K
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Y
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Y
R
L
L
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T
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K
K
A
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S
S
C
V
V
D
E
E
Q
D
V
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R
H
F
S
L
G
E
L
R
E
L
F
S
LNE
K
T
L
S
D
T
H
D
R
F
R
C
R
R
C
V
N
G
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--
D
D
S
D
C
T
C
D
L
S
N
WHHCADKRGLRDPVLQASWDAAVSFVFHQRSHEDQR
67
HHSearch
67.50
24%
29
- C1 -
1Z3I
8
?
X:
[53-554]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
V
L
R
-
P
H
Q
R
E
G
V
K
--
F
L
W
D
C
VTGRRIE
N
S
Y
G
-------
C
I
M
A
D
E
M
G
L
G
K
T
L
Q
C
-----
I
T
L
I
W
T
L
L
K
Q
---
S
PDCKP-
E
----
I
D
K
V
I
V
V
S
P
-
S
-
S
L
V
R
N
W
Y
N
E
-
V
G
K
----------------
W
L
---
G
G
R
------
V
--
Q
PVAI-------
D
---------
G
----------
G
--------
S
KDEI----------
D
SKLVNFISQQ
G
M
R
I
-------
P
-----
T
P
---------
I
L
I
I
S
Y
E
T
F
R
L
H
A
---------
E
V
L
-
H
--------------
K
G
K
-
V
G
L
V
I
C
D
E
G
H
R
L
---
K
N
S
D
---
N
--
Q
T
---
Y
---
L
A
---
L
----
N
----
S
M
-------------
N
--
A
Q
R
--------
R
V
L
I
S
G
T
P
-------
I
Q
N
D
-------
L
L
E
Y
F
S
L
V
H
F
V
-------
N
S
G
I
L
G
T
----
A
Q
E
F
K
K
---
R
F
--------------
E
I
------------------
P
-------------
I
----
L
K
GRDADASDKDRAAG
E
---
Q
--------------
K
L
Q
E
L
I
S
I
--------
V
------------------------------------
N
R
C
---
L
I
--
R
R
T
S
D
I
L
--
S
-
K
Y
L
P
V
K
I
E
Q
----
V
-
V
C
C
N
L
T
P
L
Q
K
E
L
Y
K
-
L
F
-----
L
K
Q
A
K
P
-------------------
V
E
SLQTGK---
I
-------
S
V
S
S
L
S
S
----------
I
T
S
L
K
K
L
--
C
N
--
H
P
A
--
L
I
Y
--
E
K
C
L
T
G
E
E
G
F
D
G
-----
A
---
L
-
D
L
--
F
--------------------
P
Q
N
Y
-
S
T
-----
K
A
V
E
P
Q
L
----
S
G
--------
K
M
L
--
V
L
D
Y
I
L
-----
A
-
M
TRTT--
T
---
S
D
-----
K
V
V
L
V
S
N
Y
T
Q
T
L
D
L
F
E
K
L
C
R
N
-
R
----
R
Y
----
L
---------------------------------------
Y
V
R
L
--
D
G
----
T
--------
M
--
S
I
K
K
R
A
K
I
V
E
R
F
N
----
N
PSSP
E
----
F
I
F
---
M
L
S
S
-
K
A
G
G
C
G
L
N
L
I
G
A
N
R
L
V
--------
M
F
D
P
D
W
N
P
A
N
D
E
Q
A
M
A
R
V
W
R
D
G
Q
K
K
T
C
Y
I
Y
R
L
L
S
T
G
T
I
E
E
K
I
L
Q
R
Q
A
H
K
K
A
L
--
S
S
C
V
V
D
E
E
Q
D
--------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.70
24%
0
- C- -
3MWY
1
CHD1_YEAST
W:
[258-716]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
L
A
D
E
M
G
L
G
K
T
V
Q
T
V----
A
F
I
S
W
L
I
F
A
R
---
R
------
Q
----
N
G
P
H
I
I
V
V
P
-
L
-
S
T
M
P
A
W
L
D
T
-
F
E
K
WAPDL-----------
N
C
---
I
C
Y
------
M
--
G
-----------
N
---------
Q
----------
K
--------
S
--------------
R
----------
D
T
I
R
-------
E
-----
Y
E
---------
F
Y
T
N
P
-----
K
T
M
-
K
-----
F
-
N
V
L
-
L
TTYEYILKDRAELG
S
I
K
-
W
Q
F
M
A
V
D
E
A
H
R
L
---
K
N
A
E
---
S
--
S
L
---
Y
---
E
S
---
L
----
N
----
S
F
-------------
K
--
V
A
N
--------
R
M
L
I
T
G
T
P
-------
L
Q
N
N
-------
I
K
E
L
A
A
L
V
N
F
L
-------
M
P
G
R
F
-----------------------------------------------------------------
N
----
Q
D
--------------
E
---
E
--------------
Q
E
E
Y
I
H
D
L
--------
H
------------------------------------
R
R
I
QPF
I
L
--
R
R
L
K
K
D
V
--
E
-
K
S
L
P
S
K
T
E
R
----
I
-
L
R
V
E
L
S
D
V
Q
T
E
Y
Y
K
-
N
I
LTKNY
S
-----------------------------------------------
F
S
L
----------
L
N
I
M
N
E
L
KK
A
S
--
N
H
P
--
Y
L
F
--
D
N
A
E
E
R
V
L
Q
K
F
-------------
M
--
T
R
------------
E
N
V
----
L
R
G
L
-
I
----------
M
S
S
----
G
K
--------
M
V
L
LD
Q
L
L
T
R
L
-----
K
-
K
------
D
---
G
H
-----
R
V
L
I
F
S
Q
M
V
R
M
L
D
I
L
G
D
Y
L
S
I
-
K
----
G
I
----
N
---------------------------------------
F
Q
R
L
--
D
G
----
T
--------
V
--
P
S
A
Q
R
R
I
S
I
D
H
F
N
----
S
PDSN
D
----
F
V
F
---
L
L
S
T
-
R
A
G
G
L
G
I
N
L
M
T
A
D
T
V
V
--------
I
F
D
S
D
W
N
P
Q
A
D
L
Q
A
M
A
R
A
H
R
I
G
Q
K
N
H
V
M
V
Y
R
L
V
S
K
D
T
V
E
E
E
V
L
E
R
A
R
K
K
M
I
L
--------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
62.30
26%
37
- C1 -
1Z63
2
?
A:
[40-486]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
Q
I
K
G
F
S
W
M
R
F
M
N
K
-------
L
G
F
G
-------
I
C
L
A
D
D
M
G
L
G
K
T
L
Q
T
-----
I
A
V
F
S
D
A
K
K
E
---
N
------
E
----
L
T
P
S
L
V
I
C
P
-
L
-
S
V
L
K
N
W
E
E
E
-
L
S
-----------------
K
F
A
PH
L
R
F
------
A
--
V
FH---------
E
---------
D
----------
R
--------
S
--------------
K
----------
I
K
L
E
-------
D
-----
Y
D
---------
I
I
L
T
T
Y
A
V
L
L
R
D
T
-
R
-----
L
-
K
------------------
E
V
E
-
W
K
Y
I
V
I
D
E
A
Q
N
I
---
K
N
P
Q
---
T
--
K
I
---
F
---
K
A
---
V
----
K
----
E
L
-------------
K
--
S
K
Y
--------
R
I
A
L
T
G
T
P
-------
I
E
N
K
-------
V
D
D
L
W
S
I
M
T
F
L
-------
N
P
G
L
L
G
S
----
Y
S
E
F
K
S
---
K
F
--------------
A
T
P
I
----------------
K
-------------
K
----
G
D
--------------
N
---
M
--------------
A
K
E
E
L
K
A
I
--------
I
------------------------------------
S
P
F
---
I
L
--
R
R
T
K
Y
D
K
--
A
I
I
N
D
L
P
D
K
I
E
----
T
N
V
Y
C
N
L
T
P
E
Q
A
A
M
Y
K
A
E
V
-----
E
N
L
F
N
N
-------------------
I
D
----------------------
S
V
----------
T
G
I
K
R
K
----
G
--
M
I
L
--
S
T
L
--
L
K
L
K
Q
I
V
D
H
--------------
P
A
--
L
-----------------------
L
-
K
G
-----
G
E
Q
S
V
R
R
----
S
G
--------
K
M
I
--
R
T
M
E
I
I
-----
E
-
E
------
A
L
D
E
G
D
-----
K
I
A
I
F
T
Q
F
V
D
M
G
K
I
I
R
N
I
I
E
K
-
E
----
L
N
----
T
---------------------------------------
E
V
P
F
L
-
Y
G
----
E
--------
L
--
S
K
K
E
R
D
D
I
I
S
K
F
Q
----
N
----
N
----
P
S
V
K
F
I
V
L
S
V
-
K
A
G
-
F
G
I
N
L
T
S
A
N
R
V
I
--------
H
F
D
R
W
W
N
P
---
D
Q
A
T
D
R
V
Y
R
I
G
Q
T
R
N
V
I
V
H
K
L
I
S
V
G
T
L
E
E
K
I
D
Q
L
L
A
F
K
R
S
L
--
F
K
D
I
I
S
S
G
D
S
W
I
T
E
L
S
T
-------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.19
26%
36
- C1 -
1Z6A
11
?
A:
[40-486]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
Q
I
K
G
F
S
W
M
R
F
M
N
K
-------
L
G
F
G
-------
I
C
L
A
D
D
M
G
L
G
K
T
L
Q
T
-----
I
A
V
F
S
D
A
K
K
E
---
N
------
E
----
L
T
P
S
L
V
I
C
P
-
L
-
S
V
L
K
N
W
E
E
E
-
L
S
-----------------
K
F
APH
L
R
F
------
A
--
V
F
H
---------
E
---------
D
----------
R
--------
S
--------------
K
----------
I
K
L
E
-------
D
-----
Y
D
---------
I
I
L
T
T
Y
A
V
L
L
R
D
T
-
R
-----
L
-
K
------------------
E
V
E
-
W
K
Y
I
V
I
D
E
A
Q
N
I
---
K
N
P
Q
---
T
--
K
I
---
F
---
K
A
---
V
----
K
----
E
L
-------------
K
--
S
K
Y
--------
R
I
A
L
T
G
T
P
-------
I
E
N
K
-------
V
D
D
L
W
S
I
M
T
F
L
-------
N
P
G
L
L
G
S
----
Y
S
E
F
K
S
---
K
F
--------------
A
T
P
I
----------------
K
-------------
K
----
G
D
--------------
N
---
M
--------------
A
K
E
E
L
K
A
I
--------
I
------------------------------------
S
P
F
---
I
L
--
R
R
T
K
Y
D
K
--
A
I
I
N
D
L
P
D
K
I
E
----
T
N
V
Y
C
N
L
T
P
E
Q
A
A
M
Y
K
A
E
V
-----
E
N
L
F
N
N
-------------------
I
D
----------------------
S
V
----------
T
G
I
K
R
K
G
--
M
I
--
L
----
S
T
L
--
L
K
L
K
Q
I
V
D
H
--------------
P
A
--
L
-----------------------
L
-
K
G
-----
G
E
Q
S
V
R
R
----
S
G
--------
K
M
I
--
R
T
M
E
I
I
-----
E
-
E
------
A
L
D
E
G
D
-----
K
I
A
I
F
T
Q
F
V
D
M
G
K
I
I
R
N
I
I
E
K
-
E
----
L
N
----
T
---------------------------------------
E
V
P
F
L
-
Y
G
----
E
--------
L
--
S
K
K
E
R
D
D
I
I
S
K
F
Q
----
N
----
N
----
P
S
V
K
F
I
V
L
S
V
-
K
A
G
G
F
G
I
N
L
T
S
A
N
R
V
I
--------
H
F
D
R
W
W
-----
D
Q
A
T
D
R
V
Y
R
I
G
Q
T
R
N
V
I
V
H
K
L
I
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V
G
T
L
E
E
K
I
D
Q
L
L
A
F
K
R
S
L
--
F
K
D
I
I
S
S
G
D
S
W
I
T
E
L
S
T
-------------------------------------------------------------------------------------
57
Fugue
61.49
23%
36
- C1 -
3MWY
1
CHD1_YEAST
W:
[36-783]
----DFHGIDIVINHRLKTSKTVPDLNNCKENYEFLIKWTDESHLHNTWETYESIGQVRGLKRLDNYCKQFIIEDQQVRLDPYVTAEDIEIMDMERERRLDEFEEFHVPERIIDSQRASLED
G
T
S
Q
L
Q
Y
L
V
K
W
R
R
LNYDEATW
E
N
A
T
D
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L
A
P
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Q
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K
H
F
Q
N
R
E
N
-----
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KILPQYS
S
N
Y
T
S
Q
R
P
R
F
E
K
L
S
V
Q
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P
F
I
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G
G
E
L
R
-
D
F
Q
L
T
G
I
N
--
W
M
A
F
L
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K
G
D
N
-------
G
I
L
A
D
E
M
G
L
G
K
T
V
Q
T
-----
V
A
F
I
S
W
L
I
F
A
R--
R
------
Q
----
N
G
P
H
I
I
V
V
P
-
L
-
S
T
M
P
A
W
L
D
T
-
F
E
K
WAPDLNCICYMGNQKS
R
D
---
T
I
R
------
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--
Y
-----------
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---------
F
----------
Y
--------
T
--------------
N
----------
P
K
T
M
-------
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-----
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N
---------
V
L
L
T
T
Y
E
Y
I
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---
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-----
R
-
A
E
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--------------
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I
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Q
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M
A
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D
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A
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L
---
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N
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---
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--
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---
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---
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S
---
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----
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----
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-------------
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--
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--------
R
M
L
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T
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T
P
-------
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N
N
-------
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K
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A
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-------
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---
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--------------
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------------------
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-------------
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----
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R
--------------
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---
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--------------
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F
---------------------------------------------------------
I
L
--
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R
L
K
K
D
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--
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-
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S
L
P
S
K
T
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R
----
I
-
L
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Q
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Y
Y
K
-
N
I
-----
L
T
K
-----------------------
N
---------
Y
-------
S
F
S
L
L
N
I
----------
M
N
E
L
K
K
A
--
S
N
---------
H
--
P
Y
L
F
D
N
A
E
E
R
V
L
-----
Q
---
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-
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M
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T
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------------
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N
V
----
L
R
G
L
-
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M
-----------
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----
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G
--------
K
M
V
--
L
L
D
Q
L
L
-----
T
-
R
------
L
---
K
K
DGH--
R
V
L
I
F
S
Q
M
V
R
M
L
D
I
L
G
D
Y
L
S
I
-
K
----
G
I
----
N
---------------------------------------
F
Q
R
L
--
D
G
----
T
--------
V
--
P
S
A
Q
R
R
I
S
I
D
H
F
N
----
S
----
P
DSND
F
V
F
---
L
L
S
T
-
R
A
G
G
L
G
I
N
L
M
T
A
D
T
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V
--------
I
F
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D
W
N
P
Q
A
D
L
Q
A
M
A
R
A
H
R
I
G
Q
K
N
H
V
M
V
Y
R
L
V
S
K
D
T
V
E
E
E
V
L
E
R
A
R
K
K
M
I
L
EY
N
E
P
N
A
G
E
L
S
A
I
L
K
F
G
A
G
N
M
F
T
A
T
D
N
---
Q
K
K
L
E
D
L
N
L
D
D
V
L
N
H
A
E
D
H
V
T
T
P
D
L
GE
S
H
L
G
G
E
E
F
L
K
Q
FE----------------------------------
58
Fugue
60.08
19%
4
- C1 -
1WP9
1
?
A:
[1-486]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
L
R
R
D
L
I
Q
P
R
-
I
Y
Q
E
V
I
Y
A
--
K
C
K
E
T
----------
N
-------
C
L
I
V
L
P
T
G
L
G
K
T
L
I
A
-----
M
M
I
A
E
Y
R
L
T
K
---
Y
------
G
----
G
K
V
L
M
L
A
P
T
-
K
-
P
L
V
L
Q
H
A
E
S
-
F
R
R
----------------
L
F
---
N
L
P
------
P
--
E
KIVALTGEKS-
P
---------
E
----------
E
--------
R
--------------
S
----------
K
A
W
A
-------
R
-----
A
K
---------
V
I
V
A
T
P
Q
T
I
E
N
D
L
-
L
-----
A
-
G
R
I
-
S
--------------
L
E
D
-
V
S
L
I
V
F
D
E
A
H
R
A
---
V
G
N
Y
-------
A
---
Y
---
V
F
---
I
----
A
----
R
E
-------------
Y
--
K
R
Q
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N
P
L
---
V
I
G
L
T
A
S
P
--------
G
S
T
-------
P
E
K
I
M
E
V
I
N
N
L
-------
G
I
E
H
I
E
Y
----
R
S
E
N
S
P
---
D
V
--------------
R
P
Y
V
K
G
I
R
F
E
W
V
R
V
D
L
P
E
I
Y
K
-------------
E
----
V
R
--------------
K
---
L
--------------
L
R
E
M
L
R
D
A
--------
L
------------------------------------
K
P
L
---
A
E
--
T
G
L
L
E
S
S
--
S
-
P
D
I
P
K
K
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L
----
R
-
A
G
Q
I
I
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E
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M
A
K
G
N
H
-
D
L
-----
R
G
L
L
L
Y
-------------------
H
A
---------
M
-------
A
L
K
L
H
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----------
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L
L
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T
----
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--
G
L
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--
A
L
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--
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A
K
A
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K
A
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---
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-
E
I
--
F
S
------------
D
K
R
----
M
K
K
A
-
I
S
-----
L
L
V
Q
A
K
E
I
GLD
H
P
--------
K
M
D
--
K
L
K
E
I
I
-----
R
-
E
------
Q
---
L
Q
R
KQN
S
K
I
I
V
F
T
N
Y
R
E
T
A
K
K
I
V
N
E
L
V
K
-
D
----
G
I
----
K
---------------------------------------
A
K
R
F
--
V
G
----
Q
--------
A
SK
Q
R
E
Q
K
L
I
L
D
E
F
A
R
----
G
----
E
----
F
N
V
---
L
V
A
T
-
S
V
G
E
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G
L
D
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P
E
V
D
L
V
V
--------
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Y
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P
S
A
I
R
S
I
Q
R
R
G
R
T
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R
H
M
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G
R
V
I
I
L
M
A
K
G
T
R
D
E
A
Y
Y
W
S
S
R
----------------------------------------------------------------------------------------------------------------
65
HHSearch
59.71
24%
33
- C1 -
1Z63
2
?
A:
[34-482]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
A
N
L
R
-
P
Y
Q
I
K
G
F
S
--
W
M
R
F
M
N
K
-----
L
G
F
G
-------
I
C
L
A
D
D
M
G
L
G
K
T
L
Q
T
-----
I
A
V
F
S
D
A
K
K
E
---
N
------
E
----
L
T
P
S
L
V
I
C
P
-
L
-
S
V
L
K
N
W
E
E
E
-
L
S
K
----------------
F
A
---
P
H
L
------
R
--
F
-----------
A
V
--------
F
HED-------
R
--------
S
--------------
K
----------
I
K
L
E
-------
D
-----
Y
D
---------
I
I
L
T
T
Y
A
V
L
L
R
D
T
----------
R
L
-
K
--------------
E
V
E
-
W
K
Y
I
V
I
D
E
A
Q
N
I
---
K
N
P
Q
---
T
--
K
I
---
F
---
K
A
---
V
----
K
----
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L
-------------
K
--
S
K
Y
--------
R
I
A
L
T
G
T
P
-------
I
E
N
K
-------
V
D
D
L
W
S
I
M
T
F
L
-------
N
P
G
L
L
G
S
----
Y
S
E
F
K
S
---
K
F
--------------
A
T
------------------
P
-------------
I
----
K
K
--------------
G
D
N
-
M
--------------
A
K
E
E
L
K
A
I
--------
I
------------------------------------
S
P
F
---
I
L
--
R
R
T
K
Y
D
K
AI
I
-
N
D
L
P
D
K
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E
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----
N
-
V
Y
C
N
L
T
P
E
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A
A
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K
-
A
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-----
V
E
N
L
F
N
-------------------
N
I
---------
D
SVTG
I
K
R
K
G
M
I
L
S
T
----------
L
L
K
L
K
Q
I
--
V
D
--
H
P
A
--
L
L
K
--
G
G
-----------------------------------------------------------
E
Q
S
V
R
R
----
S
G
--------
K
M
I
--
R
T
M
E
I
I
-----
E
-
E
A
L
D
---
E
---
G
D
-----
K
I
A
I
F
T
Q
F
V
D
M
G
K
I
I
R
N
I
I
E
K
E
L
----
N
T
----
E
---------------------------------------
V
P
F
L
--
Y
G
----
E
--------
L
--
S
K
K
E
R
D
D
I
I
S
K
F
Q
----
N
NP--
S
----
V
K
F
---
I
V
L
S
V
K
A
G
-
F
G
I
N
L
T
S
A
N
R
V
I
--------
H
F
D
R
W
W
N
P
---
D
Q
A
T
D
R
V
Y
R
I
G
Q
T
R
N
V
I
V
H
K
L
I
S
V
G
T
L
E
E
K
I
D
Q
L
L
A
F
K
R
S
L
--
F
K
D
I
I
S
S
G
D
S
W
I
T
-----------------------------------------------------------------------------------------
83
HHSearch
58.60
20%
17
- C1 -
1WP9
1
?
A:
[6-486]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
I
Q
P
R
-
I
Y
Q
E
V
I
Y
A
--
K
-
C
K
---------
E
T
N
-------
C
L
I
V
L
P
T
G
L
G
K
T
L
I
A
-----
M
M
I
A
E
Y
R
L
T
----
K
------
Y
----
G
G
K
V
L
M
L
A
P
T
K
-
P
L
V
L
Q
H
A
E
S
-
F
R
R
----------------
L
F
---
N
L
P
------
P
--
E
KIVAL------
T
---------
G
EKS
P
E
-----
E
--------
R
--------------
S
----------
K
A
W
A
-------
R
-----
A
K
---------
V
I
V
A
T
P
Q
T
I
E
N
D
L
-
L
-----
A
-
G
R
I
-
S
--------------
L
E
D
-
V
S
L
I
V
F
D
E
A
H
R
A
---
V
G
N
Y
---
A
--
Y
V
---
F
---
I
A
R
E
Y
K
----
R
----
Q
A
-------------
K
--
N
P
L
--------
V
I
G
L
T
A
S
P
-------
G
S
-
T
-------
P
E
K
I
M
E
V
I
N
N
L
-------
G
I
E
H
I
E
Y
----
R
S
E
N
S
P
DVR
P
Y
--------------
V
K
------------------
G
-------------
I
R
F
E
W
V
R
--------------
V
D
L
P
E
--------------
I
Y
K
E
V
R
K
L
L
R
E
M
L
R
D
A
L
------------------------------------
K
P
L
---
A
E
--
T
G
L
L
E
S
S
--
S
-
P
D
I
P
K
K
E
V
L
R
A
G
Q
I
-
I
N
E
E
M
A
K
G
N
H
D
L
R
G
-
L
L
-----
L
Y
H
A
M
A
-------------------
L
----------
K
-------
L
H
H
A
I
E
L
----------
L
-
E
T
-
Q
G
--
L
S
-------
A
L
R
--
A
Y
I
K
K
L
Y
E
E
A
K
A
-----
G
ST
K
A
-
S
K
E
I
F
S
------------
D
K
R
M
K
K
A
I
S
L
L
-
V
Q
-----
A
K
E
I
G
L
D
----
H
P
--------
K
M
D
--
K
L
K
E
I
I
-----
R
-
E
Q
L
Q
R
K-
Q
---
N
S
-----
K
I
I
V
F
T
N
Y
R
E
T
A
K
K
I
V
N
E
L
V
K
-
D
----
G
I
----
K
---------------------------------------
A
K
R
F
--
V
G
QASK-------------
Q
R
E
Q
K
L
I
L
D
E
F
A
----
R
G---
E
----
F
N
V
---
L
V
A
T
-
S
V
G
E
E
G
L
D
V
P
E
V
D
L
V
V
--------
F
Y
E
P
V
P
S
A
I
R
S
I
Q
R
R
G
R
T
G
R
H
M
---
P
G
R
V
I
I
L
M
A
K
G
T
R
D
E
A
Y
Y
W
S
S
R
-------------------------------------------------------------------------------------------------------------
74
HHSearch
54.47
22%
0
- C- -
4GL2
-
IFIH1_HUMAN
A:
[6--193]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
R
-
P
Y
Q
M
E
V
A
Q
--
P
A
L
E
---------
G
K
N
-------
I
I
I
C
L
P
T
G
C
G
K
T
R
V
A
-----
V
Y
I
A
K
D
H
L
D
K
---
K
------
K
K
A
S
E
P
G
K
V
I
V
L
V
N
-
K
V
L
L
V
E
Q
L
F
R
K
E
F
Q
P
----------------
F
L
---
K
K
W
Y
R
V
I
--
G
--
L
-----------
S
----------LKI-------
S
--------
F
--------------
P
----------
E
V
V
K
-------
S
-----
C
D
---------
I
I
I
S
T
A
Q
I
L
E
N
S
L
-
L
--------
G
V
-
Q
--------------
L
S
D
-
F
S
L
I
I
I
D
E
C
H
H
T
---
N
K
E
A
---
V
--
Y
N
---
N
---
I
M
---
R
----
H
----
Y
L
M
Q
K
L
K
N
N
R
L
K
KV
I
P
--
L
P
Q
--------
I
L
G
L
T
A
S
P
-------
G
V
G
G
ATK
Q
A
K
A
E
E
H
I
L
K
L
C
A
N
L
-------
D
A
F
T
I
K
T
VKEN
L
D
Q
L
K
N
---
Q
I
--------------
Q
E
------------------
P
-------------
C
----
K
K
--------------
F
---
A
I
A
D--------------
P
F
K
E
K
--------
L
------------------------------------
L
E
I
---
M
T
--
R
I
Q
---------------
T
Y
----
C
-
Q
M
S
P
M
S
D
F
G
T
Q
P
Y
E
-
Q
W
-----
A
I
Q
M
E
K
-------------------
K
A
A
K
E
GNR
K
E
R
V
-------
C
A
E
H
L
R
K
----------
Y
N
E
A
L
Q
I
--
N
D
--
T
I
R
M
I
D
A
Y
--
T
H
L
E
T
F
Y
N
E
E
K
D
-----
K
K
--
F
-------LD
E
T
D
R
F
L
M
T
L
F
F
E
N
----
N
K
M
L
-
K
R
L
----
A
E
N
P
--------
E
--------
K
L
T
--
K
L
R
N
T
I
-----
M
-
E
Q
Y
T
R
T
E
E
---
S
A
-----
R
G
I
I
F
T
K
T
R
Q
S
A
Y
A
L
S
Q
W
I
T
E
-
N
EKFA----------------------------------------------
A
H
H
L
--
I
G
----
A
GHSSE
F
K
P
M
--
T
Q
N
E
Q
K
E
V
I
S
K
F
R
----
T
----------
N
L
---
L
I
A
T
-
T
V
A
E
E
G
L
D
I
K
E
C
N
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V
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--------
R
Y
G
L
V
T
N
E
I
A
M
V
Q
A
R
G
R
A
R
A
D
E
S
-------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
53.36
17%
27
- C1 -
4A2Q
-
?
A:
[1-791]
MT
A
D
E
K
R
S
L
Q
C
Y
R
R
Y
I
E
R
SLNPVYVLGNMTDWLP
D
E
L
R
E
R
I
R
K
E
E
E
R
G
V
S
G
A
A
A
L
F
L
D
A
V
L
Q
LEARG
W
F
R
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M
L
D
A
M
L
A
A
GY
T
G
L
A
E
A
I
E
N
WDF
S
K
L
E
K
L
E
L
H
R
Q
L
L
K
R
I
EATMLEVDPVALI
P
Y
I
S
T
C
L
I
D
R
E
C
E
--------
E
I
Q
Q
I
S
E
N
R
S
K
A
A
G
I
T
K
L
I
E
C
L
C
R
SDK
E
-------
H
W
P
K
S
L
Q
L
A
L
D
T
T
-
G
Y
Y
R
A
S
E
L
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D
K
A
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Y
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P
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-------
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---------
A
L
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C
A
P
T
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K
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-----
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L
I
C
E
H
H
F
Q
N
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G
------
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----
K
A
K
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V
F
L
A
T
K
V
-
P
V
Y
E
Q
Q
K
N
V
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F
K
H
----------------
H
F
---
E
R
Q
G
Y
S
V
Q
G
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--
S
-----------
G
---------
E
----------
S
--------
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--------------
E
----------
K
V
I
E
-------
D
-----
S
D
---------
I
I
V
V
T
P
Q
I
L
V
N
S
F
-
E
-----
D
-
G
T
L
-
T
--------------
S
L
S
I
F
T
L
M
I
F
D
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C
H
N
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---
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G
N
H
---
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--
Y
N
---
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---
L
M
---
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----
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----
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L
-------------
E
--
Q
K
F
NSASQL
P
Q
I
L
G
L
T
A
S
V
GVGNAKN
I
E
E
T
-------
I
E
H
I
C
S
L
C
S
Y
L
-------
D
I
Q
A
I
S
T
----
V
R
E
N
I
Q
---
E
L
--------------
Q
R
------------------
F
MNKPEID
V
R
L
V
K
R
R
----
I
H
--------------
N
---
P
--------------
F
A
A
I
I
S
N
L
--------
M
------------------------------------
S
E
T
---
E
A
--
L
M
R
T
I
D
F
--
G
-
T
Q
N
Y
E
H
W
I
V
----
V
-
T
Q
R
K
C
R
L
L
Q
L
E
D
K
E
-
E
E
-----
S
R
I
C
R
A
-------------------
L
F
---------
I
-------
C
T
E
H
L
R
K
----------
Y
N
D
A
L
I
I
--
S
E
D
A
R
I
I
--
D
A
L
--
S
Y
L
T
E
F
F
T
N
V
K
N
-----
G
---
P
Y
T
E
--
L
E
------------
Q
H
L
----
T
A
K
F
-
Q
E
-----
K
E
P
E
L
I
A
----
L
S
K
DETNEN
P
K
L
E
--
E
L
V
C
I
L
-----
D
-
D
------
A
---
Y
R
Y
NPQ
T
R
T
L
L
F
A
K
T
R
A
L
V
S
A
L
K
K
C
M
E
E
-
N
----
P
I
----
L
---------------------------------------
N
-
Y
I
--
K
P
----
G
--------
V
--
L
D
N
R
-------------------------
L
---
L
I
A
T
-
S
V
V
Q
-------
C
N
L
V
V
--------
L
Y
E
Y
S
G
N
V
T
K
M
I
Q
V
G
S
K
------------
C
I
L
V
T
S
K
T
E
V
V
E
N
E
K
C
N
R
Y
K
E
E
M
--
M
N
K
A
V
E
K
I
Q
--------
K
W
D
E
E
T
F
A
---
K
K
I
H
N
L
Q
M
K
E
R
V
L
-------------------------------------------------------------
6
PsiBlast_PDB
51.63
36%
-27
- C1 -
3DMQ
1
RAPA_ECOLI
A:
[155-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
P
H
Q
L
N
I
A
H
--
D
V
G
R
R
-------
H
A
P
R
-------
V
L
L
A
D
E
V
G
L
G
K
T
I
E
A
-----
G
M
I
L
H
Q
Q
L
L
S
---
G
------
A
----
A
E
R
V
L
I
I
V
P
-
E
-
T
L
Q
H
Q
W
L
V
E
-
M
L
R
----------------
R
F
N--
L
R
F
------
A
--
L
-----------
F
---------
D
----------
D
--------
E
--------------
R
----------
Y
A
E
A
-------
Q
-----
H
D
AYNPFDTEQ
L
V
I
C
S
L
D
F
A
R
R
S
K
-
Q
-----
R
L
E
H
L
-
C
--------------
E
A
E
-
W
D
L
L
V
V
D
E
A
H
H
L
V
W
S
E
D
A
P
---
S
--
R
E
---
Y
---
Q
A
---
I
----
E
----
Q
L
-------------
A
--
E
H
V
P
G
------
V
L
L
L
T
A
T
P
-------
E
Q
L
G
-------
M
E
S
H
F
A
R
L
R
L
L
-------
D
P
N
R
F
H
D
----
F
A
Q
F
V
E
---
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
51.44
19%
-22
- C1 -
2V1X
4
RECQ1_HUMAN
A:
[43-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
R
-
P
L
Q
L
E
T
I
N
--
V
T
M
A
---------
G
K
E
-------
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
-----
Q
L
P
A
L
C
S
------------------
D
G
F
T
L
V
I
C
P
L
I
-
S
L
M
E
D
Q
L
M
V
-
L
K
Q
----------------
L
G
----
I
S
------
A
--
T
-----------
M
---------
L
----------
N
ASSS
K
E
H
V
K
W
V
H
A
E
M
--------
V
----------
N
K
N
S
-------
E
-----
L
K
---------
L
I
Y
V
T
P
E
K
I
A
K
S
K
-
M
F
M
S
R
L
E
-
K
A
Y
-
E
--------------
A
R
R
-
F
T
R
I
A
V
D
E
V
H
C
C
---
S
Q
W
G
---
H
--
D
F
---
R
P
D
Y
K
A
---
L
G
I
L
K
R
----
Q
F
-------------
P
--
N
A
S
--------
L
I
G
L
T
A
T
A
-------
T
N
H
V
-------
L
T
D
A
Q
K
I
L
C
I
E
-------
K
C
F
T
F
T
A
-------------
S
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
P
N
L
Y
Y
E
----
V
-
R
Q
K
--
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
----
E
D
--------
F
I
E
--
D
I
V
K
L
I
-----
N
-
G
R
Y----
K
---
G
Q
-----
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
-
L
----
G
I
----
H
---------------------------------------
A
G
A
Y
--
H
A
----
N
--------
L
--
E
P
E
D
K
T
T
V
H
R
K
W
S
----
A
N---
E
----
I
Q
V
---
V
V
A
T
-
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
--------
H
H
S
M
S
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
-----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.07
36%
-15
- C1 -
4S20
-
RAPA_ECOLI
K:
[161-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
P
H
Q
L
N
I
A
H
--
D
V
G
R
R
-------
H
A
P
R
-------
V
L
L
A
D
E
V
G
L
G
K
T
I
E
A
-----
G
M
I
L
H
Q
Q
L
L
S
---
G
------
A
----
A
E
R
V
L
I
I
V
P
-
E
-
T
L
Q
H
Q
W
L
V
E
-
M
L
R
----------------
R
F
N--
L
R
F
------
A
--
L
-----------
F
---------
D
----------
D
--------
E
--------------
R
----------
Y
A
E
A
-------
Q
-----
H
D
AYNPFDTEQ
L
V
I
C
S
L
D
F
A
R
R
S
K
-
Q
-----
R
L
E
H
L
-
C
--------------
E
A
E
-
W
D
L
L
V
V
D
E
A
H
H
L
VWS
E
D
A
P
---
S
--
R
E
---
Y
---
Q
A
---
I
----
E
----
Q
L
-------------
A
--
E
H
V
PG------
V
L
L
L
T
A
T
P
-------
E
Q
L
G
-------
M
E
S
H
F
A
R
L
R
L
L
-------
D
P
N
R
F
H
D
----
F
A
Q
F
V
E
---
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
49.58
17%
-18
- C1 -
3TBK
2
DDX58_MOUSE
A:
[2-527]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
K
P
R
-
N
Y
Q
L
E
L
A
L
--
P
A
K
K
---------
G
K
N
-------
T
I
I
C
A
P
T
G
C
G
K
T
F
V
S
-----
L
L
I
C
E
H
H
L
K
K
---
F
PCG---
Q
----
K
G
K
V
V
F
F
A
N
-
Q
I
P
V
Y
E
Q
Q
A
T
V
-
F
S
R
----------------
Y
F
---
E
R
L
G
Y
N
---
I
--
A
-----------
S
---------
I
S
GATSDSV--
S
--------
V
--------------
Q
----------
H
I
I
E
-------
D
-----
N
D
---------
I
I
I
L
T
P
Q
I
L
V
N
N
L
-
N
-----
N
-
G
A
I
P
S
--------------
L
S
V
-
F
T
L
M
I
F
D
E
C
H
N
T
---
S
K
N
H
---
P
--
Y
N
---
Q
---
I
M
---
F
----
R
----
Y
L
D
H
K
L
GESR
D
----
P
--
L
P
Q
--------
V
V
G
L
T
A
S
V
-------
G
V
G
D
-------
A
K
T
A
E
E
A
M
Q
H
I
C
K
L
C
A
A
L
D
A
S
V
I
A
T
----
V
R
D
N
V
A
---
E
L
--------------
E
Q
V
V
Y
K
--------------
P
-------------
Q
----
K
I
S
R
K
V
A
---------
S
---
R
--------------
T
S
N
T
F
K
C
I
--------
I
------------------------------------
S
Q
L
---
M
K
E
T
E
K
L
A
K
D
V
--
S
-
E
E
L
G
K
L
F
---------
Q
I
Q
N
R
E
F
G
T
Q
K
Y
E
-
Q
W
-----
I
V
G
V
H
K
A
C
S
V
FQMAD
K
E
E
E
S
R
V
C
K
A
L
F
---------
L
-------
Y
T
S
H
L
R
K
----------
Y
N
D
A
L
I
I
--
S
E
D
A
Q
M
T
--
D
A
L
--
N
Y
L
K
A
F
F
H
D
V
R
-------------
E
--
T
E
R
E
L
---------
T
R
R
----
F
E
E
K
-
L
E
E
L
E
K
V
S
R
D
P
S
N
E
----
N
P
--------
K
L
R
--
D
L
Y
L
V
L
-----
Q
-
E
E
Y
H
L
K-
P
---
E
T
-----
K
T
I
L
F
V
K
T
R
A
L
V
D
A
L
K
K
W
I
E
E
-
N
----
P
A
LSFL
K
---------------------------------------
P
G
I
L
TG----------------------------------------
D
----
N
N
I
---
L
I
A
T
-
S
V
A
D
E
G
I
D
I
A
E
C
N
L
V
I
--------
L
Y
E
Y
V
G
N
V
I
K
M
I
Q
T
R
G
R
-
G
R
A
R
---
D
S
K
C
F
L
L
T
S
S
A
D
V
I
E
K
E
K
A
N
M
I
K
E
K
I
M
--
N
E
S
I
--------------------------------------------------------------------------------------------------
86
HHSearch
49.55
18%
-7
- C1 -
2DB3
3
VASA1_DROME
A:
[77-404]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
P
T
-
P
I
Q
K
C
S
I
P
--
V
I
S
S
---------
G
R
D
-------
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
-----
L
L
P
I
L
S
K
L
L
E
---
D
P
H
E
L
E
L
G
----
R
P
Q
V
V
I
V
S
P
T
R
-
E
L
A
I
Q
I
F
N
E
-
A
R
K
----------------
F
A
---
F
E
S
------
Y
--
L
K
I
G
I
V
Y
G
GTS
F
R
---------
H
----------
Q
--------
N
--------------
E
----------
C
I
T
R
-------
G
-----
C
H
---------
V
V
I
A
T
P
G
R
L
L
D
F
V
-
D
-----
R
-
T
F
I
-
T
--------------
F
E
D
-
T
R
F
V
V
L
D
E
A
D
R
M
---
L
D
M
G
---
F
S
E
D
M
---
R
---
R
I
---
M
----
T
----
H
V
TMR----------
P
--
E
H
Q
--------
T
L
M
F
S
A
T
F
-------
P
E
E
I
-------
Q
R
M
A
G
E
F
L
----------
K
N
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
V
A
I
G
I
V
G
---
G
A
C
S
-
D
V
-----
K
Q
T
----------------------------------------------------------------------------------------------------------------------------------------------
I
Y
E
V
N
K
----
Y
A
--------
K
R
S
--
K
L
I
E
I
L
-----
S
-
E
------
Q
---
A
D
-----
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
-
K
----
E
F
----
P
---------------------------------------
T
T
S
I
--
H
G
----
D
--------
R
--
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
----
N
G---
S
----
M
K
V
---
L
I
A
T
-
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
--------
N
Y
D
M
P
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
-----------------------------------------------------------------------------------------------------------------------------
90
HHSearch
46.98
20%
-5
- C1 -
1OYW
1
RECQ_ECOLI
A:
[24-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
F
R
-
P
G
Q
E
E
I
I
D
--
T
V
L
S
---------
G
R
D
-------
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
-----
Q
I
P
A
L
L
L
------------------
N
G
L
T
V
V
V
S
P
L
I
-
S
L
M
K
D
Q
V
D
Q
-
L
Q
A
----------------
N
G
---
V
A
A
------
A
--
C
L
N
ST-------
Q
T
R
E
Q
Q
L
E
--
V
----------
M
--------
T
--------------
G
----------
C
R
T
G
-------
Q
-----
I
R
---------
L
L
Y
I
A
P
E
R
L
M
L
D
N
-
F
-----
L
-
E
H
L
-
A
--------------
H
W
N
-
P
V
L
L
A
V
D
E
A
H
C
I
---
S
Q
W
G
---
H
--
D
F
R
P
E
Y
---
A
A
---
L
----
G
Q
L
R
Q
R
F
-------------
P
--
T
L
P
--------
F
M
A
L
T
A
T
A
-------
D
D
T
T
-------
R
Q
D
I
V
R
L
L
G
L
N
-------
D
P
L
I
Q
I
S
------
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
P
N
I
R
----------
Y
M
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
----
F
K
--------
P
L
D
--
Q
L
M
R
Y
V
-----
Q
E
Q
------
R
---
G
K
-----
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
-
K
----
G
I
----
S
---------------------------------------
A
A
A
Y
--
H
A
----
G
--------
L
--
E
N
N
V
R
A
D
V
Q
E
K
F
Q
----
R
D---
D
----
L
Q
I
---
V
V
A
T
-
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
--------
H
F
D
I
P
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
46.77
16%
1
- C1 -
4A4Z
4
SKI2_YEAST
A:
[36-549]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
P
F
E
L
D
-
T
F
Q
K
E
A
V
Y
--
H
L
E
Q
---------
G
D
S
-------
V
F
V
A
A
H
T
S
A
G
K
T
V
V
A
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---------------------------------------------------------------------------------------------------------------