@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu25130: (2016-07-09 )
MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRKKIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAIGAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEELAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDSKNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRFEIEMLKEKQFDDTLLEKILQQ
Atome Classification :
(20 SA)
.........10....-...-----.20........30........40........50...---.....60...--.--.--.--...70.......-----.80.-.......90........100.-......110...-.-..-.120.......130...--....140.......150.--......160.......170.......180.......190.------.--.......200.......210.......220--.......230.......240.......-250-.......260.......270.......280.......290.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLRIGSHVSMSG
K
H
M
-
L
L
A-----AS
Q
E
A
V
SYGA
N
T
F
M
I
YTGAPQNTRRKKIEDLNIEA
G
---
R
A
H
M
Q
E-NGI--
D
--
E
--
I
--
I
V
HA
P
Y
I
I
NIGN-----TTNP-
S
T
F
E
L
G
V
D
F
L
R
S
E
I
E
R
T
A
AIG-
A
K
Q
I
V
LHPGAHV-G-A
G
-
A
E
A
G
I
K
K
I
I
E
G
L
N
E
VID--PNQ
N
V
Q
I
A
L
ETMAGK
G
S
E
--
C
G
R
S
F
E
E
L
A
Q
I
I
E
GVTHN
E
Q
L
S
V
C
F
D
TCHTHDAGY
N
I
--
V
------
E
--
D
F
D
G
V
L
N
E
F
D
K
I
IGI
D
R
I
K
V
L
H
INDSKNVK--GARKDRHENIGFGEI
G
F
D
A
L
Q
Y
V
V
H
H
E
-
Q
L
K
-
D
I
P
K
I
LETPYVGEDKKNKKP
P
Y
R
F
E
I
E
M
L
K
EKQF
D
D
T
L
L
E
K
I
LQQ
1
PsiBlast_PDB
97.97
79%
-96
- C2 -
3AAL
4
END4_GEOKA
A:
[6-298]
-
L
K
I
G
S
H
V
S
M
S
G
K
K
M
-
L
L
A
-----
A
S
E
E
A
A
S
Y
G
A
N
T
F
M
I
Y
T
G
A
P
Q
N
T
K
R
K
S
I
E
E
L
N
I
E
A
G
---
R
Q
H
M
Q
A
-
H
G
I
--
E
--
E
--
I
--
V
V
H
A
P
Y
I
I
N
I
G
N
-----
T
T
N
L
-
D
T
F
S
L
G
V
D
F
L
R
A
E
I
E
R
T
E
A
I
G
-
A
K
Q
L
V
L
H
P
G
A
H
V
-
G
-
A
G
-
V
E
A
G
L
R
Q
I
I
R
G
L
N
E
V
L
T
--
R
E
Q
N
V
Q
I
A
L
E
T
M
A
G
K
G
S
E
--
C
G
R
T
F
E
E
L
A
Y
I
I
D
G
V
A
Y
N
D
K
L
S
V
C
F
D
T
C
H
T
H
D
A
G
Y
D
I
--
V
------
N
--
D
F
D
G
V
L
E
E
F
D
R
I
I
G
L
G
R
L
K
V
L
H
I
N
D
S
K
N
P
R
--
G
S
R
K
D
R
H
E
N
I
G
F
G
H
I
G
F
A
A
L
N
Y
I
V
H
H
P
-
Q
L
E
-
D
I
P
K
I
L
E
T
P
Y
V
G
E
D
K
N
N
K
K
P
P
Y
K
H
E
I
A
M
L
R
A
Q
S
F
D
D
Q
L
L
E
K
I
---
23
HHSearch
90.01
79%
-18
- C2 -
3AAL
4
END4_GEOKA
A:
[6-298]
-
L
K
I
G
S
H
V
S
M
S
G
K
K
M
-
L
L
A
-----
A
S
E
E
A
A
S
Y
G
A
N
T
F
M
I
Y
T
G
A
P
Q
N
T
K
R
K
S
I
E
E
L
N
I
E
A
G
---
R
Q
H
M
Q
A
-
H
G
I
--
E
--
E
--
I
--
V
V
H
A
P
Y
I
I
N
I
G
N
-----
T
-
T
N
L
D
T
F
S
L
G
V
D
F
L
R
A
E
I
E
R
T
E
A
I
G
-
A
K
Q
L
V
L
H
P
G
A
H
V
-
G
-
A
G
-
V
E
A
G
L
R
Q
I
I
R
G
L
N
E
V
L
T
--
R
E
Q
N
V
Q
I
A
L
E
T
M
A
G
K
G
S
E
--
C
G
R
T
F
E
E
L
A
Y
I
I
D
G
V
A
Y
N
D
K
L
S
V
C
F
D
T
C
H
T
H
D
A
G
Y
D
I
--
V
------
N
--
D
F
D
G
V
L
E
E
F
D
R
I
I
G
L
G
R
L
K
V
L
H
I
N
D
S
K
N
P
R
--
G
S
R
K
D
R
H
E
N
I
G
F
G
H
I
G
F
A
A
L
N
Y
I
V
H
H
P
-
Q
L
E
D
I
-
P
K
I
L
E
T
P
Y
V
G
E
D
K
N
N
K
K
P
P
Y
K
H
E
I
A
M
L
R
A
Q
S
F
D
D
Q
L
L
E
K
I
---
2
PsiBlast_PDB
88.44
78%
-18
- C2 -
1XP3
5
END4_BACAN
A:
[11-307]
-
L
K
I
G
S
H
V
S
M
S
G
K
K
M
-
L
L
A
-----
A
S
E
E
A
V
S
Y
G
A
T
T
F
M
I
Y
T
G
A
P
Q
N
T
R
R
K
P
I
E
E
L
N
I
E
A
G
---
R
K
H
M
E
Q
-
N
G
I
--
E
--
E
--
I
--
I
I
H
A
P
Y
I
I
N
V
G
N
-----
T
T
K
P
-
E
T
F
Q
L
G
V
D
F
L
R
M
E
I
E
R
T
S
A
L
G
V
A
K
Q
I
V
L
H
P
G
A
H
V
-
G
-
A
G
-
A
D
A
G
I
Q
Q
I
I
K
G
L
N
E
V
L
T
--
P
D
Q
T
V
N
I
A
L
E
T
M
A
G
K
G
T
E
--
C
G
R
S
F
E
E
I
A
K
I
I
D
G
V
K
Y
N
E
K
L
S
V
C
F
D
T
C
H
T
H
D
A
G
Y
D
I
--
V
------
N
--
N
F
D
G
V
L
N
E
F
D
K
I
V
G
I
D
R
L
Q
V
L
H
I
N
D
S
K
N
V
R
--
G
A
G
K
D
R
H
E
N
I
G
F
G
H
I
G
Y
K
A
L
H
H
I
V
H
H
P
-
Q
L
T
-
H
V
P
K
I
L
E
T
P
Y
V
G
E
D
K
K
D
K
K
P
P
Y
K
L
E
I
E
M
L
K
N
G
T
F
D
E
G
L
L
E
K
I
K
A
Q
6
PsiBlast_PDB
73.04
33%
-112
- C2 -
3AAM
2
?
A:
[2-250]
-
P
R
Y
G
F
H
L
S
I
A
G
K
K
G
-
V
A
G
-----
A
V
E
E
A
T
A
L
G
L
T
A
F
Q
I
F
A
K
S
P
R
S
W
R
P
R
A
L
S
P
A
E
V
E
A
F
---
R
A
L
R
E
A
-
S
G
G
--
L
--
P
--
A
--
V
I
H
A
S
Y
L
V
N
L
G
A
-----
E
G
E
---
L
W
E
K
S
V
A
S
L
A
D
D
L
E
K
A
A
L
L
G
-
V
E
Y
V
V
V
H
P
G
S
G
R
-
P
-
E
R
-
V
K
E
G
A
L
K
A
L
R
----
L
A
G
--
V
R
S
R
P
V
L
L
V
E
N
T
A
G
G
G
E
K
--
V
G
A
R
F
E
E
L
A
W
L
V
A
----
D
T
P
L
Q
V
C
L
D
T
C
H
A
Y
A
A
G
Y
D
V
--
A
------
E
--
D
P
L
G
V
L
D
A
L
D
R
A
V
G
L
E
R
V
P
V
V
H
L
N
D
S
V
G
G
L
--
G
S
R
V
D
H
H
A
H
L
L
Q
G
K
I
G
-
E
G
L
K
R
V
F
L
D
P
-
R
L
K
-
D
R
V
F
I
L
E
T
P
------------------------------------
43
Fugue
68.40
31%
-0
- C2 -
1QTW
3
END4_ECOLI
A:
[1-285]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
TS
A
--
Q
--
I
--
L
P
H
D
S
Y
L
I
N
L
G
H
-----
P
-
V
T
-
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
-
M
-
Q
I
S
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
E
T
I
--------
N
P
D
I
W
A
E
E
I
A
W
L
K
A
Q
Q
T
E
K
A
V
A
------
24
HHSearch
66.67
32%
-10
- C2 -
1QTW
3
END4_ECOLI
A:
[1-283]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
--
S
AQ
I
--
L
P
H
D
S
Y
L
I
N
L
G
H
-----
P
-
V
T
-
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
-
M
Q
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
--
R
T
P
A
E
C
E
K
--
T
F
A
D
F
A
R
T
----
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
E
T
I
N
P
D
--------
I
W
A
E
E
I
A
W
L
K
A
Q
Q
T
E
K
A
--------
27
HHSearch
65.21
33%
-28
- C2 -
3AAM
2
?
A:
[2-266]
-
P
R
Y
G
F
H
L
S
I
A
G
K
K
G
-
V
A
G
-----
A
V
E
E
A
T
A
L
G
L
T
A
F
Q
I
F
A
K
S
P
R
S
W
R
P
R
A
L
S
P
A
E
V
E
A
F
---
R
A
L
R
E
A
S
G
G
L
-----
P
--
A
--
V
I
H
A
S
Y
L
V
N
L
G
A
-----
E
-
G
--
E
L
W
E
K
S
V
A
S
L
A
D
D
L
E
K
A
A
L
L
G
-
V
E
Y
V
V
V
H
P
G
S
G
R
-
P
-----
E
R
V
K
E
G
A
L
K
A
L
R
L
A
G
V
---
R
S
R
P
V
L
L
V
E
N
T
A
G
G
G
E
K
--
V
G
A
R
F
E
E
L
A
W
L
V
A
D
----
T
P
L
Q
V
C
L
D
T
C
H
A
Y
A
A
G
Y
D
V
--
A
------
E
--
D
P
L
G
V
L
D
A
L
D
R
A
V
G
L
E
R
V
P
V
V
H
L
N
D
S
V
G
G
L
--
G
S
R
V
D
H
H
A
H
L
L
Q
G
K
I
G
-
E
G
L
K
R
V
F
L
D
P
-
R
L
K
D
R
-
V
F
I
L
E
T
P
R
G
P
E
-------
E
D
A
W
N
L
R
V
F
R
A
W
-------------
8
PsiBlast_PDB
64.70
31%
-7
- C2 -
1QTW
3
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
SA
Q
--
I
--
L
P
H
D
S
Y
L
I
N
L
G
H
-----
P
V
T
E
-
A
-
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
Q
-
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
E
T
-------------------------------------
7
PsiBlast_PDB
64.64
31%
-3
- C2 -
1QUM
6
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
SA
Q
--
I
--
L
P
H
D
S
Y
L
I
N
L
G
H
-----
P
V
T
E
-
A
-
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
Q
-
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
E
T
-------------------------------------
21
PsiBlast_CBE
64.30
31%
-7
- C2 -
2NQJ
1
END4_ECOLI
B:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
SA
Q
--
I
--
L
P
H
D
S
Y
L
I
N
L
G
H
-----
P
V
T
E
-
A
-
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
Q
-
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
Q
T
-------------------------------------
12
PsiBlast_PDB
64.11
31%
-8
- C2 -
2NQ9
6
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
SA
Q
--
I
--
L
P
H
D
S
A
L
I
N
L
G
H
-----
P
V
T
E
-
A
-
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
Q
-
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
E
T
-------------------------------------
9
PsiBlast_PDB
64.02
31%
-6
- C2 -
2NQH
4
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
SA
Q
--
I
--
L
P
H
D
S
Y
L
I
N
L
G
H
-----
P
V
T
E
-
A
-
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
Q
-
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
Q
T
-------------------------------------
10
PsiBlast_PDB
63.72
31%
-5
- C2 -
2NQJ
5
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
SA
Q
--
I
--
L
P
H
D
S
Y
L
I
N
L
G
H
-----
P
V
T
E
-
A
-
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
Q
-
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
Q
T
-------------------------------------
11
PsiBlast_PDB
63.60
31%
-7
- C2 -
4K1G
7
END4_ECOLI
A:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
SA
Q
--
I
--
L
P
A
D
S
Y
L
I
N
L
G
H
-----
P
V
T
E
-
A
-
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
Q
-
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
E
T
-------------------------------------
45
Fugue
63.58
29%
15
- C2 -
1QTW
3
END4_ECOLI
A:
[1-285]
M
K
Y
I
G
A
H
V
S
A
A
G
---G
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
--
S
--
A
Q
I
L
P
H
D
S
Y
------LINLG
H
P
V
T
-
E
A
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
-
M
Q
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
K
T
Q
--
G
V
T
A
V
I
E
N
T
A
G
Q
--
G
SN
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
-
S
T
FG
S
R
V
D
R
-
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
E
T
I
----
N
P
D
I
----
W
A
E
E
I
A
W
L
K
A
Q
Q
T
E
-----
K
A
V
A
-
22
PsiBlast_CBE
63.30
31%
-5
- C2 -
4K1G
8
END4_ECOLI
B:
[1-262]
M
K
Y
I
G
A
H
V
S
A
A
G
G
---
L
A
N
-----
A
A
I
R
A
A
E
I
D
A
T
A
F
A
L
F
T
K
N
Q
R
Q
W
R
A
A
P
L
T
T
Q
T
I
D
E
F
---
K
A
A
C
E
K
-
Y
H
Y
--
T
SA
Q
--
I
--
L
P
A
D
S
Y
L
I
N
L
G
H
-----
P
V
T
E
-
A
-
L
E
K
S
R
D
A
F
I
D
E
M
Q
R
C
E
Q
L
G
-
L
S
L
L
N
F
H
P
G
S
H
L
M
Q
-
I
S
-
E
E
D
C
L
A
R
I
A
E
S
I
N
I
A
L
D
--
K
T
Q
G
V
T
A
V
I
E
N
T
A
G
Q
G
S
N
--
L
G
F
K
F
E
H
L
A
A
I
I
D
G
V
E
D
K
S
R
V
G
V
C
I
D
T
C
H
A
F
A
A
G
Y
D
L
RT
P
------
A
--
E
C
E
K
T
F
A
D
F
A
R
T
V
G
F
K
Y
L
R
G
M
H
L
N
D
A
K
S
T
F
--
G
S
R
V
D
R
H
H
S
L
G
E
G
N
I
G
H
D
A
F
R
W
I
M
Q
D
D
-
R
F
D
-
G
I
P
L
I
L
E
T
-------------------------------------
25
HHSearch
61.59
33%
41
- C2 -
4HNO
6
END4_THEMA
A:
[4-286]
M
I
K
I
G
A
H
M
P
I
S
K
--
G
-
F
D
R
-----
V
P
Q
D
T
V
N
I
G
G
N
S
F
Q
I
F
P
H
N
A
R
S
W
S
A
K
L
P
S
D
E
A
A
T
K
F
---
K
R
E
M
K
K
-
H
G
I
--
D
--
W
EN
A
--
F
C
H
S
G
Y
L
I
N
L
A
S
-----
P
-
K
D
-
D
I
W
Q
K
S
V
E
L
L
K
K
E
V
E
I
C
R
K
L
G
-
I
R
Y
L
N
I
H
P
G
S
H
L
-
G
-
T
G
-
E
E
E
G
I
D
R
I
V
R
G
L
N
E
V
L
N
--
N
T
E
G
V
V
I
L
L
E
N
V
S
Q
K
G
G
N
--
I
G
Y
K
L
E
Q
L
K
K
I
R
D
L
V
D
Q
R
D
R
V
A
I
T
Y
D
T
C
H
G
F
D
S
G
Y
D
I
--
T
------
K
K
E
G
V
E
A
L
L
N
E
I
E
S
L
F
G
L
E
R
L
K
M
I
H
L
N
D
S
K
Y
P
L
--
G
A
A
K
D
R
H
E
R
I
G
S
G
F
I
G
E
E
G
F
A
V
F
F
S
F
K
E
I
Q
E
-
V
-
P
W
I
L
E
T
P
G
G
N
E
E
H
A
---
E
D
I
K
K
V
F
E
I
I
E
K
F
G
------------
3
PsiBlast_PDB
60.20
34%
32
- C2 -
2X7V
3
END4_THEMA
A:
[1-262]
M
I
K
I
G
A
H
M
P
I
S
--
K
G
-
F
D
R
-----
V
P
Q
D
T
V
N
I
G
G
N
S
F
Q
I
F
---
P
H
N
A
R
S
W
S
A
K
L
P
S
D
E
A
A
T
K
F
K
R
E
M
K
K
-
H
G
I
--
D
WE
N
--
A
--
F
C
H
S
G
Y
L
I
N
L
A
S
-----
P
K
D
--
D
I
W
Q
K
S
V
E
L
L
K
K
E
V
E
I
C
R
K
L
G
-
I
R
Y
L
N
I
H
P
G
S
H
L
-
G
-
T
G
-
E
E
E
G
I
D
R
I
V
R
G
L
N
E
V
L
N
--
N
T
E
G
V
V
I
L
L
E
N
V
S
Q
K
G
G
N
--
I
G
Y
K
L
E
Q
L
K
K
I
R
D
L
V
D
Q
R
D
R
V
A
I
T
Y
D
T
C
H
G
F
D
S
G
Y
D
I
--
T
K
K
----
E
--
G
V
E
A
L
L
N
E
I
E
S
L
F
G
L
E
R
L
K
M
I
H
L
N
D
S
K
Y
P
L
--
G
A
A
K
D
R
H
E
R
I
G
S
G
F
I
G
E
E
G
F
A
V
F
F
S
F
K
-
E
I
Q
-
E
V
P
W
I
L
E
T
P
------------------------------------
4
PsiBlast_PDB
60.19
34%
34
- C2 -
2X7W
4
END4_THEMA
A:
[1-262]
M
I
K
I
G
A
H
M
P
I
S
--
K
G
-
F
D
R
-----
V
P
Q
D
T
V
N
I
G
G
N
S
F
Q
I
F
---
P
H
N
A
R
S
W
S
A
K
L
P
S
D
E
A
A
T
K
F
K
R
E
M
K
K
-
H
G
I
--
D
WE
N
--
A
--
F
C
H
S
G
Y
L
I
N
L
A
S
-----
P
K
D
--
D
I
W
Q
K
S
V
E
L
L
K
K
E
V
E
I
C
R
K
L
G
-
I
R
Y
L
N
I
H
P
G
S
H
L
-
G
-
T
G
-
E
E
E
G
I
D
R
I
V
R
G
L
N
E
V
L
N
--
N
T
E
G
V
V
I
L
L
E
N
V
S
Q
K
G
G
N
--
I
G
Y
K
L
E
Q
L
K
K
I
R
D
L
V
D
Q
R
D
R
V
A
I
T
Y
D
T
C
H
G
F
D
S
G
Y
D
I
--
T
K
K
----
E
--
G
V
E
A
L
L
N
E
I
E
S
L
F
G
L
E
R
L
K
M
I
H
L
N
D
S
K
Y
P
L
--
G
A
A
K
D
R
H
E
R
I
G
S
G
F
I
G
E
E
G
F
A
V
F
F
S
F
K
-
E
I
Q
-
E
V
P
W
I
L
E
T
P
------------------------------------
5
PsiBlast_PDB
56.18
34%
44
- C2 -
4HNO
6
END4_THEMA
A:
[4-265]
-------
M
I
K
I
G
A
H
M
-
P
I
S
KGFDR
V
P
Q
D
T
V
N
I
G
G
N
S
F
Q
I
F
---
P
H
N
A
R
S
W
S
A
K
L
P
S
D
E
A
A
T
K
F
K
R
E
M
K
K
-
H
G
I
--
D
WE
N
--
A
--
F
C
H
S
G
Y
L
I
N
L
A
S
-----
P
K
D
--
D
I
W
Q
K
S
V
E
L
L
K
K
E
V
E
I
C
R
K
L
G
-
I
R
Y
L
N
I
H
P
G
S
H
L
-
G
-
T
G
-
E
E
E
G
I
D
R
I
V
R
G
L
N
E
V
L
N
--
N
T
E
G
V
V
I
L
L
E
N
V
S
Q
K
G
G
N
--
I
G
Y
K
L
E
Q
L
K
K
I
R
D
L
V
D
Q
R
D
R
V
A
I
T
Y
D
T
C
H
G
F
D
S
G
Y
D
I
--
T
K
K
----
E
--
G
V
E
A
L
L
N
E
I
E
S
L
F
G
L
E
R
L
K
M
I
H
L
N
D
S
K
Y
P
L
--
G
A
A
K
D
R
H
E
R
I
G
S
G
F
I
G
E
E
G
F
A
V
F
F
S
F
K
-
E
I
Q
-
E
V
P
W
I
L
E
T
P
------------------------------------