@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu26850: (2016-07-11 )
MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGIQFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRGLSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSSNFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLAGGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPVLTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW
Atome Classification :
(25 SA)
-.........10........20..-.-.-....----.30........40........50.....---.-..60........70........80........90.....-...100.......110.......120.......130....-----------------...---------140.......150.......160.......170.......180.......190..-..-...200.......210.......220...-----------...--.230-.--...----.----.------.240.......250---....---....--260.......270.......280.......290......-.--300.......310-----.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
E
Y
T
Y
LGRTG
L
R
V
S
R
L
C
L
GT-MN-F-G-VDTD----
E
K
T
A
F
R
I
M
D
E
A
L
DNG
I
Q
F
F
DTA
N
I
Y
GWG---K-NAGL
T
E
S
I
I
G
K
W
F
A
QGGQR
R
E
K
V
V
L
A
T
KVYEPISDPNDG-PNDMRG
L
S
L
Y
K
I
R
R
H
L
E
G
S
L
K
R
L
Q
T
D
H
I
E
L
Y
Q
M
HHIDRRT-----------------
P
W
D
---------
E
I
W
E
A
F
E
T
Q
VRSG
K
V
D
Y
IGSSNFA
G
W
H
L
V
K
A
Q
A
E
A
E
K
R
R
F
M
G
L
V
T
E
Q
H
K
Y
S
L
L
E
R
-
T
A-EMEVLPAARDLG
L
G
V
V
A
WSPLAGGLLG
G
K
-----------
A
LK--SNAG-T--R
T
A
----
K
----
R
------
A
D
L
I
E
K
H
R
L
Q
L
E
K
----
F
S
D
L
---
C
K
E
L
--
G
EKEA
N
V
A
L
A
W
V
LANPVLTAPIIG
P
R
T
V
E
Q
L
R
D
T
I
K
A
V
E
-I--SL
D
K
E
I
L
R
M
L
N
D
I-----FPGPGGETPEAYAW
10
PsiBlast_PDB
86.78
30%
0
- C- -
2A79
4
KCAB2_RAT
A:
[5-321]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
4
PsiBlast_PDB
81.75
31%
0
- C- -
3V0U
-
PERR_RAUSE
A:
[1-330]
-
M
P
R
V
K
L
G
T
Q
G
L
E
V
S
K
L
G
F
G
C
-
M
G
-
L
-
S
-
G
D
Y
N
DALP
E
E
Q
G
I
A
V
I
K
E
A
F
N
C
G
I
T
F
F
D
T
S
D
I
Y
G
-------
E
N
G
S
N
E
E
L
L
G
K
A
L
K
Q
--
L
P
R
E
K
I
Q
V
G
T
K
F
--
G
I
H
E
I
G
F
S
-
G
V
K
A
K
G
T
P
D
Y
-
V
R
S
C
C
E
A
S
L
K
R
L
D
V
D
Y
I
D
L
F
Y
I
H
R
I
D
T
T
V
-----------------
P
I
E
---------
I
T
M
G
E
L
K
K
L
V
E
E
G
K
I
K
Y
V
G
L
S
E
A
S
P
D
T
I
R
R
A
H
A
------
V
H
P
V
T
A
L
Q
I
E
Y
S
L
W
T
R
-
D
I
-
E
D
E
I
V
P
L
C
R
Q
L
G
I
G
I
V
P
Y
S
-----------------------------------------------------------
N
K
Q
I
Y
Y
R
----
I
E
A
L
---
S
Q
K
H
--
G
C
T
P
V
Q
L
A
L
A
W
V
L
H
Q
G
E
D
V
V
P
I
P
G
T
T
K
I
K
N
L
H
N
N
V
G
A
L
K
-
V
--
K
L
T
K
E
D
L
K
E
I
S
D
A
-----
V
P
------------
3
PsiBlast_PDB
80.90
31%
0
- C- -
3V0T
1
PERR_RAUSE
A:
[1-327]
-
M
P
R
V
K
L
G
T
Q
G
L
E
V
S
K
L
G
F
G
C
-
M
G
-
L
-
S
-----P---
E
E
Q
G
I
A
V
I
K
E
A
F
N
C
G
I
T
F
F
D
T
S
D
I
Y
G
-------
E
N
G
S
N
E
E
L
L
G
K
A
L
K
Q
--
L
P
R
E
K
I
Q
V
G
T
K
F
--
G
I
H
E
I
G
F
S
-
G
V
K
A
K
G
T
P
D
Y
-
V
R
S
C
C
E
A
S
L
K
R
L
D
V
D
Y
I
D
L
F
Y
I
H
R
I
D
T
T
V
-----------------
P
I
E
---------
I
T
M
G
E
L
K
K
L
V
E
E
G
K
I
K
Y
V
G
L
S
E
A
S
P
D
T
I
R
R
A
H
A
------
V
H
P
V
T
A
L
Q
I
E
Y
S
L
W
T
R
-
D
I
-
E
D
E
I
V
P
L
C
R
Q
L
G
I
G
I
V
P
Y
S
P
I
G
R
G
L
F
W
G
K
-----------
A
I
K
E--------------------------------------
Y
Y
R
----
I
E
A
L
---
S
Q
K
H
--
G
C
T
P
V
Q
L
A
L
A
W
V
L
H
Q
G
E
D
V
V
P
I
P
G
T
T
K
I
K
N
L
H
N
N
V
G
A
L
K
-
V
--
K
L
T
K
E
D
L
K
E
I
S
D
A
-----
V
P
------------
20
PsiBlast_PDB
79.00
32%
-131
- C8 -
1YNP
11
?
A:
[21-293]
-
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
-
M
S
-
L
-
G
---
T
D
----
E
T
K
A
R
R
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
--------
N
Q
G
L
N
E
Q
F
V
G
K
A
L
K
G
---
R
R
Q
D
I
I
L
A
T
K
V
------------------
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
G
T
I
D
D
-----------------
P
I
D
---------
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
------
I
R
P
N
V
I
K
E
Y
L
K
R
S
N
I
V
S
I
M
M
Q
Y
S
I
L
D
R
-
R
P
-
E
-
E
W
F
P
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
-----------
P
L
P
--
E
G
E
G
-
Y
--
L
N
Y
---------
R
------
Y
D
E
L
K
L
L
R
E
S
L
P
T
----
D
R
P
L
---
H
E
----------
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
-
A
--
T
-------------------------------
45
HHSearch
78.62
32%
11
- C8 -
1LQA
1
TAS_ECOLI
A:
[1-345]
-
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
-
M
T
-
F
-
G
-
E
Q
N
S
----
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
P
PRP
E
-
T
Q
G
L
T
E
T
Y
V
G
N
W
L
A
K
H
G
-
S
R
E
K
L
I
I
A
S
K
V
S
G
P
S
R
N
N
D
K
G
I
R
P
D
-
Q
A
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
P
Q
R
P
T
NCFGKL
G
Y
S
W
T
DSAPAV
S
L
L
---------
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
D
K
H
D
L
P
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
-
S
F
-
E
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
-----------
Y
L
N
--
G
A
K
P
-
A
GA
R
N
T
----
L
----
F
SRFT--
R
Y
S
G
E
Q
T
Q
K
A
V
A
A
----
Y
V
D
I
---
A
R
R
H
--
G
L
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
L
S
E
D
V
L
A
E
I
E
A
V
-----
H
Q
V
Y
T
Y
P
A
------
49
HHSearch
77.45
32%
-103
- C8 -
1YNP
13
?
A:
[21-316]
-
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
-
M
S
-
L
-
G
---
T
D
----
E
T
K
A
R
R
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
N
--------
Q
G
L
N
E
Q
F
V
G
K
A
L
K
G
---
R
R
Q
D
I
I
L
A
T
K
V
------------------
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
G
T
I
D
D
-----------------
P
I
D
---------
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
P
N
V
I
K
E
Y
L
K
------
R
S
N
I
V
S
I
M
M
Q
Y
S
I
L
D
R
-
R
P
-
E
-
E
W
F
P
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
-----------
P
L
P
--
E
G
E
----------------------------
G
Y
L
N
Y
R
Y
D
E
----
L
K
L
L
---
R
E
S
L
PT
D
R
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
A
T
--
P
L
T
A
E
E
R
Q
H
I
Q
K
L
-----
A
K
A
A
V
Y
E
Q
H
R
----
9
PsiBlast_PDB
76.95
30%
-7
- C8 -
1EXB
1
KCAB2_RAT
A:
[4-320]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
68
Fugue
76.91
30%
11
- C8 -
1QRQ
1
KCAB2_RAT
A:
[1-325]
L
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
T
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
A
E
V
V
L
G
N
I
I
K
K
K
-----
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
-----
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSG
I
P
P
Y
S
RA
S
L
K
--
G
Y
Q
W
-
L
--
K
D
K
----
I
----
L
------
S
E
E
G
R
R
Q
Q
A
K
L
K
E
----
L
Q
A
I
---
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
G
N
K
P
Y
--------
7
PsiBlast_PDB
76.61
30%
-5
- C8 -
3LUT
1
KCAB2_RAT
A:
[39-355]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
8
PsiBlast_PDB
76.57
30%
-6
- C8 -
1QRQ
1
KCAB2_RAT
A:
[4-320]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSG
I
P
P
Y
---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
1
PsiBlast_PDB
76.54
30%
14
- C8 -
1LQA
1
TAS_ECOLI
A:
[1-346]
-
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
-
M
T
-
F
-
G
-
E
Q
N
S
----
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
P
PRP
E
-
T
Q
G
L
T
E
T
Y
V
G
N
W
L
A
K
H
G
S
R
-
E
K
L
I
I
A
S
K
V
S
G
P
S
R
N
N
D
K
G
-
I
R
P
D
Q
A
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
P
Q
R
P
T
NCFGKL
G
Y
---------
S
W
T
DSAPAVS
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
D
K
H
D
L
P
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
-
S
F
-
E
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
-----------
Y
L
N
GA
K
P
A
G
-
A
--
R
N
T
----
L
----
F
------
S
R
F
T
R
Y
S
G
E
Q
T
Q
K
A
V
A
A
Y
V
D
I
---
A
R
R
H
--
G
L
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
L
S
E
D
V
L
A
E
I
E
A
V
H
Q
V
Y
T
Y
P
A
P
----------
15
PsiBlast_PDB
76.45
30%
-5
- C8 -
4JTD
1
KCAB2_RAT
A:
[5-321]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
11
PsiBlast_PDB
76.37
30%
-7
- C8 -
2R9R
1
KCAB2_RAT
A:
[5-321]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
50
HHSearch
76.36
29%
-10
- C8 -
3LUT
1
KCAB2_RAT
A:
[37-358]
-
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
-
T
F
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
--------
A
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-----
E
T
E
-
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
-
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
-----------
Y
D
S
--
G
I
P
P
Y
S
--
R
A
S
----
L
KGY
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
----
L
Q
A
I
---
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
G
N
K
----------
48
HHSearch
76.32
29%
-10
* C8 *
3EAU
3
KCAB2_RAT
A:
[3-324]
-
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
-
W
V
-
T
-
F
G
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
--------
A
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
G
G
K
A
-----
E
T
E
-
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
-
E
K
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
-----------
Y
D
S
--
G
I
P
P
Y
S
--
R
A
S
LKGY
Q
----
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
----
L
Q
A
I
---
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
G
N
K
----------
5
PsiBlast_PDB
76.28
30%
-5
- C8 -
3EB3
2
KCAB2_RAT
A:
[5-321]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
-----
A
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
14
PsiBlast_PDB
76.13
30%
-6
- C8 -
4JTC
1
KCAB2_RAT
A:
[5-321]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
12
PsiBlast_PDB
75.93
30%
-7
- C8 -
3LNM
1
KCAB2_RAT
A:
[5-321]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
6
PsiBlast_PDB
75.65
30%
-6
- C8 -
3EAU
3
KCAB2_RAT
A:
[5-321]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
13
PsiBlast_PDB
75.38
30%
-6
- C8 -
4JTA
1
KCAB2_RAT
A:
[5-321]
---
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
-
F
-
G
-
G
Q
I
T
----
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
G
---
K
-----
A
E
V
V
L
G
N
I
I
K
K
K
G
W
R
R
S
S
L
V
I
T
T
K
I
F
W
-----
G
G
K
-
A
E
T
E
R
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
---------
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
E
K
V
-
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
YDSGIPPY---
S
R
A
--
S
L
K
G
-
Y
--
Q
W
L
----
K
----
D
------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
----
L
K
E
L
Q
A
I
A
E
R
L
--
G
C
T
L
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
L
S
S
S
I
V
H
E
I
D
S
I
-----
L
-------------
39
PsiBlast_CBE
57.08
31%
-93
- C8 -
1GVE
5
ARK73_RAT
A:
[10-204]
------------------
L
G
A
-
M
E
-
M
-
G
-
R
R
M
D
----
V
T
S
S
S
A
S
V
R
A
F
L
Q
R
G
H
T
E
I
D
T
A
F
V
Y
A
N
G
---
Q
-----
S
E
T
I
L
G
D
L
G
L
G
L
G
R
S
G
C
K
V
K
I
A
T
K
A
-
A
P
M
F
G
K
T
L
K
-
P
A
D
--------
V
R
F
Q
L
E
T
S
L
K
R
L
Q
C
P
R
V
D
L
F
Y
L
H
F
P
D
H
G
T
-----------------
P
I
E
---------
E
T
L
Q
A
C
H
Q
L
H
Q
E
G
K
F
V
E
L
G
L
S
N
Y
V
S
W
E
V
A
E
I
C
T
L
C
K
K
N
G
W
I
M
P
T
V
Y
Q
G
M
Y
N
A
I
T
R
-
Q
V
-
E
T
E
L
F
P
C
L
R
H
F
G
L
R
F
Y
A
F
N
P
L
A
G
G
L
L
T
G
R
----------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
56.95
32%
-85
- C8 -
2BP1
2
ARK72_HUMAN
B:
[43-237]
------------------
L
G
T
-
M
E
-
M
-
G
-
R
R
M
D
----
A
P
A
S
A
A
A
V
R
A
F
L
E
R
G
H
T
E
L
D
T
A
F
M
Y
S
D
G
---
Q
-----
S
E
T
I
L
G
G
L
G
L
G
L
G
---
C
R
V
K
I
A
T
K
-----
A
N
P
W
D
G
-----
K
S
L
K
P
D
S
V
R
S
Q
L
E
T
S
L
K
R
L
Q
C
P
Q
V
D
L
F
Y
L
H
A
P
D
H
G
T
-----------------
P
V
E
---------
E
T
L
H
A
C
Q
R
L
H
Q
E
G
K
F
V
E
L
G
L
S
N
Y
A
S
W
E
V
A
E
I
C
T
L
C
K
S
N
G
W
I
L
P
T
V
Y
Q
G
M
Y
N
A
T
T
R
-
Q
V
-
E
T
E
L
F
P
C
L
R
H
F
G
L
R
F
Y
A
Y
N
P
L
A
G
G
L
L
T
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
56.93
32%
-89
- C8 -
2BP1
2
ARK72_HUMAN
D:
[43-237]
------------------
L
G
T
-
M
E
-
M
-
G
-
R
R
M
D
----
A
P
A
S
A
A
A
V
R
A
F
L
E
R
G
H
T
E
L
D
T
A
F
M
Y
S
D
G
---
Q
-----
S
E
T
I
L
G
G
L
G
L
G
L
G
G
G
D
C
R
V
K
I
A
T
K
-----
A
N
P
W
D
G
-----
K
S
L
K
P
D
S
V
R
S
Q
L
E
T
S
L
K
R
L
Q
C
P
Q
V
D
L
F
Y
L
H
A
P
D
H
G
T
-----------------
P
V
E
---------
E
T
L
H
A
C
Q
R
L
H
Q
E
G
K
F
V
E
L
G
L
S
N
Y
A
S
W
E
V
A
E
I
C
T
L
C
K
S
N
G
W
I
L
P
T
V
Y
Q
G
M
Y
N
A
T
T
R
-
Q
V
-
E
T
E
L
F
P
C
L
R
H
F
G
L
R
F
Y
A
Y
N
P
L
A
G
G
L
L
T
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
56.90
32%
-89
- C8 -
2BP1
2
ARK72_HUMAN
C:
[43-237]
------------------
L
G
T
-
M
E
-
M
-
G
-
R
R
M
D
----
A
P
A
S
A
A
A
V
R
A
F
L
E
R
G
H
T
E
L
D
T
A
F
M
Y
S
D
G
---
Q
-----
S
E
T
I
L
G
G
L
G
L
G
L
G
---
C
R
V
K
I
A
T
K
-----
A
N
P
W
D
G
-----
K
S
L
K
P
D
S
V
R
S
Q
L
E
T
S
L
K
R
L
Q
C
P
Q
V
D
L
F
Y
L
H
A
P
D
H
G
T
-----------------
P
V
E
---------
E
T
L
H
A
C
Q
R
L
H
Q
E
G
K
F
V
E
L
G
L
S
N
Y
A
S
W
E
V
A
E
I
C
T
L
C
K
S
N
G
W
I
L
P
T
V
Y
Q
G
M
Y
N
A
T
T
R
-
Q
V
-
E
T
E
L
F
P
C
L
R
H
F
G
L
R
F
Y
A
Y
N
P
L
A
G
G
L
L
T
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
55.66
32%
-85
- C8 -
2BP1
2
ARK72_HUMAN
A:
[43-237]
------------------
L
G
T
-
M
E
-
M
-
G
-
R
R
M
D
----
A
P
A
S
A
A
A
V
R
A
F
L
E
R
G
H
T
E
L
D
T
A
F
M
Y
S
D
G
---
Q
-----
S
E
T
I
L
G
G
L
G
L
G
L
G
G
G
D
C
R
V
K
I
A
T
K
-----
A
N
P
W
D
G
-----
K
S
L
K
P
D
S
V
R
S
Q
L
E
T
S
L
K
R
L
Q
C
P
Q
V
D
L
F
Y
L
H
A
P
D
H
G
T
-----------------
P
V
E
---------
E
T
L
H
A
C
Q
R
L
H
Q
E
G
K
F
V
E
L
G
L
S
N
Y
A
S
W
E
V
A
E
I
C
T
L
C
K
S
N
G
W
I
L
P
T
V
Y
Q
G
M
Y
N
A
T
T
R
-
Q
V
-
E
T
E
L
F
P
C
L
R
H
F
G
L
R
F
Y
A
Y
N
P
L
A
G
G
L
L
T
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------