@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu27540: (2016-07-13 )
MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARSGVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYTEETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIADISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKMPPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK
Atome Classification :
(20 SA)
------........--.10---.--..---.....20........30........40.....-----...50........60........70........80........90.--.......100--------------.---------------.-...----...110........120.--.-.....130....------------...140.......150...-...-----.160.......170.......180..------.------.....190.......200.......210......--.220.......230..-.....240.......250..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MLHQFSRN--ELA---I--
G
K
---
E
G
L
E
T
LKNS
T
V
A
V
L
GVG
G
V
G
S
F
A
A
E
A
L
A
R
SGV-----
G
R
I
L
L
V
DKDDVD
I
T
N
V
N
R
Q
L
H
A
L
L
S
TVGQP
K
V
D
L
M
K
A
R
IADINPE
C
--
E
V
I
A
L
K
M
F
Y---------------
T
---------------
E
-
E
T
Y
----
E
Q
F
F
-
D
YGL
D
Y
V
IDASD
T
--
I
-
C
Y
K
I
H
L
M
K
E
C
L
K
------------RDI
P
L
I
S
SMGAANKTDP
T
R
-
F
Q
I
-----
A
DISKTH
T
D
P
I
A
K
V
V
R
T
K
L
R
K
E
-
G
I
K
------
K
------
G
V
Q
V
I
FSDES
P
I
V
I
R
E
D
V
R
K
E
VGN
D
E
A
K
I
RKAKM--PPSSNA
F
V
P
S
V
A
G
L
IM-
G
G
H
V
V
M
D
L
L
KDIEIKRVKDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
96.67
40%
0
- C- -
4D79
7
TCDA_ECOLI
B:
[11-236]
--------
Q
R
F
G
G
T
--
A
R
L
---
Y
--
G
E
---
K
A
L
Q
L
F
A
D
A
H
I
C
V
V
G
I
G
G
V
G
S
W
A
A
E
A
L
A
R
T
G
I
-----
G
A
I
T
L
I
D
M
D
D
V
C
V
T
N
T
N
R
Q
I
H
A
L
R
D
N
V
G
L
A
K
A
E
V
M
A
E
R
I
R
Q
I
N
P
E
C
--
R
V
T
V
V
D
D
F
V
---------------
T
---------------
P
-
D
N
V
----
A
Q
Y
M
-
S
V
G
Y
S
Y
V
I
D
A
I
D
S
--
V
-
R
P
K
A
A
L
I
A
Y
C
R
R
------------
N
K
I
P
L
V
T
T
G
G
A
G
G
Q
I
D
P
T
Q
-
I
Q
V
-----
T
D
L
A
K
T
I
Q
D
P
L
A
A
K
L
R
E
R
L
K
S
D
F
G
V
V
------
K
N
SKGKL
G
V
D
C
V
F
S
T
E
A
L
V
Y
P
Q
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
96.67
40%
0
- C- -
4D7A
5
TCDA_ECOLI
B:
[11-236]
--------
Q
R
F
G
G
T
--
A
R
L
---
Y
--
G
E
---
K
A
L
Q
L
F
A
D
A
H
I
C
V
V
G
I
G
G
V
G
S
W
A
A
E
A
L
A
R
T
G
I
-----
G
A
I
T
L
I
D
M
D
D
V
C
V
T
N
T
N
R
Q
I
H
A
L
R
D
N
V
G
L
A
K
A
E
V
M
A
E
R
I
R
Q
I
N
P
E
C
--
R
V
T
V
V
D
D
F
V
---------------
T
---------------
P
-
D
N
V
----
A
Q
Y
M
-
S
V
G
Y
S
Y
V
I
D
A
I
D
S
--
V
-
R
P
K
A
A
L
I
A
Y
C
R
R
------------
N
K
I
P
L
V
T
T
G
G
A
G
G
Q
I
D
P
T
Q
-
I
Q
V
-----
T
D
L
A
K
T
I
Q
D
P
L
A
A
K
L
R
E
R
L
K
S
D
F
G
V
V
------
K
NSKGKL
G
V
D
C
V
F
S
T
E
A
L
V
Y
P
Q
S
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
73.89
35%
-70
- C1 -
4D79
5
TCDA_ECOLI
A:
[10-267]
-------
R
Q
R
F
G
G
T
--
A
R
L
---
Y
--
G
E
---
K
A
L
Q
L
F
A
D
A
H
I
C
V
V
G
I
G
G
V
G
S
W
A
A
E
A
L
A
R
T
G
I
-----
G
A
I
T
L
I
D
M
D
D
V
C
V
T
N
T
N
R
Q
I
H
A
L
R
D
N
V
G
L
A
K
A
E
V
M
A
E
R
I
R
Q
I
N
P
E
C
--
R
V
T
V
V
D
D
F
V
---------------
T
---------------
P
-
D
N
V
----
A
Q
Y
M
S
V
-
G
Y
S
Y
V
I
D
A
I
D
S
--
V
-
R
P
K
A
A
L
I
A
Y
C
R
R
------------
N
K
I
P
L
V
T
T
G
G
A
G
G
Q
I
D
P
T
Q
-
I
Q
V
-----
T
D
L
A
K
T
I
Q
D
P
L
A
A
K
L
R
E
R
L
K
S
D
F
G
V
V
K
N
SKGK
L
------
G
V
D
C
V
F
S
T
E
A
L
V
Y
P
----------------------
G
F
G
A
A
T
M
V
T
A
T
F
G
F
V
A
-
V
S
H
A
L
K
K
M
M
A
K
A
A
R
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Fugue
72.21
36%
9
- C1 -
4D79
5
TCDA_ECOLI
A:
[3-268]
VVIS
D
A
W
R
Q
R
F
G
G
T
--
A
R
L
---
Y
--
G
E
---
K
A
L
Q
L
F
A
D
A
H
I
C
V
V
G
I
G
G
V
G
S
W
A
A
E
A
L
A
R
T
G
I
-----
G
A
I
T
L
I
D
M
D
D
V
C
V
T
N
T
N
R
Q
I
H
A
L
R
D
N
V
G
L
A
K
A
E
V
M
A
E
R
I
R
Q
I
N
P
E
C
--
R
V
T
V
V
D
D
F
V
---------------
T
---------------
P
-
D
N
V
----
A
Q
Y
M
-
S
V
G
Y
S
Y
V
I
D
A
I
D
S
--
V
-
R
P
K
A
A
L
I
A
Y
C
R
R
------------
N
K
I
P
L
V
T
T
G
G
A
G
G
Q
I
D
P
T
Q
-
I
Q
V
-----
T
D
L
A
K
T
I
Q
D
P
L
A
A
K
L
R
E
R
L
K
S
D
F
G
V
V
------
K
N
SKGKL
G
V
D
C
V
F
S
T
E
A
L
V
--------------------
Y
P
--
G
F
G
A
A
T
M
V
T
A
T
F
G
F
V
A
-
V
S
H
A
L
K
K
M
M
A
K
A
A
R
Q
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
58.35
33%
-131
- C2 -
1JW9
2
MOEB_ECOLI
B:
[24-161]
------------------------------
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
-----
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
S
D
A
T
V
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
--
A
I
T
P
V
N
A
L
L
---------------
D
---------------
D
-
A
E
L
----
A
A
L
I
-
A
E
H
-
D
L
V
L
D
C
T
D
N
--
V
-
A
V
R
N
Q
L
N
A
G
C
F
A
------------
A
K
V
P
L
V
S
--
G
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
58.33
33%
-134
- C2 -
1JWB
2
MOEB_ECOLI
B:
[24-161]
------------------------------
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
-----
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
S
D
A
T
V
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
--
A
I
T
P
V
N
A
L
L
---------------
D
---------------
D
-
A
E
L
----
A
A
L
I
-
A
E
H
-
D
L
V
L
D
C
T
D
N
--
V
-
A
V
R
N
Q
L
N
A
G
C
F
A
------------
A
K
V
P
L
V
S
--
G
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
HHSearch
58.25
25%
-113
- C1 -
4NNJ
8
UBA1_YEAST
A:
[32-182]
-------
E
S
L
Y
S
R
Q
--
L
Y
V
---
L
--
G
K
---
E
A
M
L
K
M
Q
T
S
N
V
L
I
L
G
L
K
G
L
G
V
E
I
A
K
N
V
V
L
A
G
V
-----
K
S
M
T
V
F
D
P
E
P
V
Q
L
A
D
L
S
T
Q
F
F
L
T
E
K
D
I
G
Q
K
R
G
D
V
T
R
A
K
L
A
E
L
N
A
Y
V
--
P
V
N
V
L
D
S
L
----------------
D
------------------
D
-----
V
T
Q
L
-
S
-
Q
F
Q
V
V
V
-
A
T
D
T
VS
L
-
E
D
K
V
K
I
N
E
F
C
H
S
------------
S
G
I
R
F
I
S
S
E
T
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Fugue
57.54
20%
-106
- C1 -
1Y8Q
3
SAE2_HUMAN
B:
[6-550]
------------------
G
---
L
--
P
R
---
E
L
A
E
A
V
A
G
G
R
V
L
V
V
G
A
G
G
I
G
C
E
L
L
K
N
L
V
L
T
G
F
-----
S
H
I
D
L
I
D
L
D
T
I
D
V
S
N
L
N
R
Q
F
L
F
Q
K
K
H
V
G
R
S
K
A
Q
V
A
K
E
S
V
L
Q
F
Y
P
K
A
--
N
I
V
A
Y
H
D
S
I
---------------
M
---------------
N
-
P
D
Y
----
N
V
E
F
-
F
R
Q
F
I
L
V
M
N
A
L
D
N
--
R
-
A
A
R
N
H
V
N
R
M
C
L
A
------------
A
D
V
P
L
I
E
S
G
T
A
-----
G
Y
L
-
G
Q
V
-----
T
T
I
K
K
G
V
T
E
C
Y
E
C
H
P
K
P
T
Q
R
T
F
-
P
G
A
------
T
------
I
R
N
T
P
S
E
P
I
H
C
I
V
W
A
K
Y
L
F
N
Q
L
F
G
E
E
D
A
D
Q
E
V
S
P
--
D
R
A
D
P
E
A
A
W
E
T
K
E
W
A
K
S
T
G
Y
D
P
V
K
L
F
T
K
L
F
K
D
D
I
R
Y
L
L
TMDKLWRK
R
K
P
P
V
P
L
D
W
A
E
V
Q
S
QLGLKDQ
Q
V
L
D
V
K
S
Y
A
R
L
F
S
K
S
I
E
T
L
R
V
H
L
A
E
K
GDG
A
E
L
I
W
D
KDD
P
S
A
M
D
F
V
T
S
A
A
N
L
R
M
H
I
F
S
M
N
M
K
S
R
F
D
I
K
S
M
A
G
N
I
I
P
A
I
A
T
T
N
A
V
I
A
G
L
I
V
L
E
G
L
K
I
L
S
GKIDQ
C
R
T
I
F
L
N
KQPNPRKKL
L
V
P
C
A
L
D
P
P
NPNCYVCAS
K
P
E
V
T
V
R
L
N
VHKVT
V
L
T
L
Q
D
KIVKEKFAMV
A
P
D
V
Q
I
EDGKGTILISSEEGETEANNHKKLSEFGIRNG
S
R
L
Q
A
D
DFLQD
Y
T
L
L
I
N
I
L
H
S
EDLGKDVEFEVVGDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Fugue
56.50
22%
-19
- C1 -
1JW9
4
MOEB_ECOLI
B:
[2-248]
AELSDQ
E
M
L
R
Y
N
R
Q
II
L
R
G
---
F
--
D
F
---
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
-----
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
S
D
A
T
V
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
--
A
I
T
P
V
N
A
L
L
---------------
D
---------------
D
-
A
E
L
----
A
A
L
I
-
A
-
E
H
D
L
V
L
D
C
T
D
N
--
V
-
A
V
R
N
Q
L
N
A
G
C
F
A
------------
A
K
V
P
L
V
S
G
A
A
I
R
M
-----
E
-
G
Q
I
-----
T
V
F
T
Y
Q
D
G
E
P
C
Y
R
C
L
S
R
L
F
G
E
A
-
G
V
M
----------------------------
A
P
L
I
G
V
I
G
S
L
Q
A
M
E
A
I
K
M
L
AG
Y
G
K
P
A
S
G
K
I
V
M
Y
D
A
M
T
-
C
Q
F
R
E
M
K
L
M
R
N
P
G
C
E
V
C
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
HHSearch
54.94
24%
-0
- C1 -
3H5N
4
?
A:
[92-317]
-------
N
N
R
Y
S
R
N
--
F
L
H
Y
Q
S
Y
--
G
A
N
P
V
L
V
Q
D
K
L
K
N
A
K
V
V
I
L
G
C
G
G
I
G
N
H
V
S
V
I
L
A
T
S
G
I
-----
G
E
I
I
L
I
D
N
D
Q
I
E
N
T
N
L
T
R
Q
V
L
F
S
E
D
D
V
G
K
N
K
T
E
V
I
K
R
E
L
L
K
R
N
S
E
I
--
S
V
S
E
I
A
L
N
I
---------------
N
---------------
D
-
Y
T
D
----
L
H
K
V
-
P
-
E
A
D
I
W
V
V
S
A
D
H
--
P
F
N
L
I
N
W
V
N
K
Y
C
V
R
------------
A
N
Q
P
Y
I
N
A
G
Y
V
N
D
I
A
---
V
-
F
G
P
-----
L
Y
V
P
G
K
T
G
C
Y
E
C
Q
K
--------------------------
K
E
----
N
I
D
H
K
---
I
-----------
K
L
I
N
S
R
F
--
K
P
A
T
F
A
P
V
N
N
V
A
A
A
L
C
-
A
A
D
V
I
K
F
I
G
K
Y
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
54.82
23%
-22
- C1 -
1JW9
4
MOEB_ECOLI
B:
[9-216]
-------
M
L
R
Y
N
R
Q
--
I
I
L
---
R
GF
D
F
---
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
-----
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
S
D
A
T
V
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
--
A
I
T
P
V
N
A
L
L
---------------
D
---------------
D
-
A
E
L
----
A
A
L
I
-
A
-
E
H
D
L
V
L
D
C
T
D
N
--
V
-
A
V
R
N
Q
L
N
A
G
C
F
A
------------
A
K
V
P
L
V
S
G
A
A
I
R
M
E
G
---
Q
-
I
T
V
-----
F
T
Y
Q
D
G
E
P
C
Y
R
C
L
S
R
L
F
G
---------------------------------------------------------
E
A
G
V
M
A
P
L
I
G
V
I
G
S
L
Q
-
A
M
E
A
I
K
M
L
A
G
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
HHSearch
52.98
25%
-90
- C1 -
1Y8Q
3
SAE2_HUMAN
B:
[6-198]
------------------
G
---
L
--
P
R
---
E
L
A
E
A
V
A
G
G
R
V
L
V
V
G
A
G
G
I
G
C
E
L
L
K
N
L
V
L
T
G
F
-----
S
H
I
D
L
I
D
L
D
T
I
D
V
S
N
L
N
R
Q
F
L
F
Q
K
K
H
V
G
R
S
K
A
Q
V
A
K
E
S
V
L
Q
F
Y
P
K
A
--
N
I
V
A
Y
H
D
S
I
---------------
M
---------------
N
P
D
Y
N
----
V
E
F
F
-
R
-
Q
F
I
L
V
M
N
A
L
D
N
--
R
-
A
A
R
N
H
V
N
R
M
C
L
A
------------
A
D
V
P
L
I
E
S
G
T
A
G
Y
L
G
Q
----
V
T
T
------
I
K
K
G
V
T
E
C
Y
E
C
H
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Fugue
49.87
18%
-0
- C1 -
3CMM
1
UBA1_YEAST
A:
[3-1015]
---GEI
D
E
S
L
Y
S
R
Q
--
L
Y
V
---
L
--
G
K
---
E
A
M
L
K
M
Q
T
S
N
V
L
I
L
G
L
K
G
L
G
V
E
I
A
K
N
V
V
L
A
G
V
-----
K
S
M
T
V
F
D
P
E
P
V
Q
L
A
D
L
S
T
Q
F
F
L
T
E
K
D
I
G
Q
K
R
G
D
V
T
R
A
K
L
A
E
L
N
A
Y
V
--
P
V
N
V
L
D
S
L
D
---------------
D
---------------
V
-
T
Q
L
----
S
Q
F
Q
-----
V
V
V
A
T
D
T
V
S
--
L
-
E
D
K
V
K
I
N
E
F
C
H
S
------------
S
G
I
R
F
I
S
S
E
T
R
G
L
-----------------
F
G
N
T
F
V
D
L
G
D
E
F
T
V
L
D
P
T
G
E
-
E
P
R
------
T
------
G
M
V
S
D
I
E
P
D
G
T
V
T
M
L
D
D
------------
N
R
H
G
L
--
E
D
G
N
F
V
R
F
S
E
V
E
G
L
------
D
K
L
N
D
G
T
L
F
K
V
E
V
L
G
P
F
AFRIGSVKEYGEYK
K
G
G
I
F
T
E
V
K
V
P
R
K
I
S
F
K
S
L
K
Q
Q
L
S
N
P
E
F
V
F
SDFAK
F
D
R
A
A
Q
L
H
L
G
F
Q
A
L
H
Q
F
A
V
R
H
NGELPRTMN
D
E
D
A
N
E
L
I
K
L
V
T
D
L
S
V
Q
Q
PEVLGEGVDVN
E
D
L
I
K
E
L
S
Y
Q
A
RGDI
P
G
V
V
A
F
F
G
G
L
V
A
Q
E
V
L
K
A
C
SGKFTPLK
Q
F
M
Y
F
D
SLESLPDPKN
F
P
R
N
EKTTQPVNSRY
D
N
Q
I
A
V
FG
L
D
F
Q
K
K
I
A
N
S
K
V
F
L
V
G
SG
A
I
G
C
E
M
L
K
N
W
A
L
L
GLGSGSD
G
Y
I
V
V
T
D
NDSIEKSNLNRQFLFRPKDVGKN
K
S
E
V
A
A
E
A
V
C
A
M
NPDLKGK
I
N
A
K
IDKVGPETEEIFN
D
S
F
W
E
S
LD
F
V
T
N
ALDN
V
D
A
R
T
Y
V
D
R
R
C
V
F
Y
R
K
P
L
L
E
S
G
T
L
GT
K
G
N
T
Q
V
I
I
P
RLTESYSSSRDPPEKSIP
L
C
T
L
R
SFPNK
I
D
H
T
I
A
W
A
K
S
L
F
Q
G
Y
FT
D
S
A
E
N
V
N
M
Y
L
T
QPN
F
V
E
Q
T
L
KDV
K
G
V
L
E
S
I
S
D
S
L
SSKPHN
F
E
D
C
I
K
W
A
R
L
E
F
E
K
K
FN
H
D
I
K
Q
L
L
F
N
FPKDAKTSNGEPFWSGAKR
A
P
T
P
L
E
FDIYN
N
D
H
F
H
F
V
V
A
G
A
S
L
R
A
Y
N
Y
GIKSDDSNSKPN
V
D
E
Y
K
S
V
I
D
H
MII
P
E
F
T
P
N
AN
L
K
I
Q
VNDDDPDPE
I
D
Q
L
V
SSLPDPSTLAG
F
K
L
E
P
V
D
FEKDDDTNH
H
I
E
F
I
T
A
C
S
N
C
R
A
Q
N
Y
F
I
E
T
A
D
R
Q
K
T
K
F
I
A
G
R
I
I
P
A
I
A
T
T
T
S
L
V
T
G
L
V
N
L
E
L
Y
K
L
I
D
NKTDIEQ
Y
K
N
G
F
V
N
LALP
F
F
G
F
S
E
P
IAS
P
K
G
E
Y
NN
K
K
Y
D
KIW
D
R
F
D
I
K
G
DIK
L
S
D
L
I
E
H
F
E
K
D
EG
L
E
I
T
M
L
S
Y
GVSLLYASFFP
P
K
K
L
K
E
R
L
NLP
I
T
Q
L
V
K
L
V
T
KKDIPAHVS
T
M
I
L
E
I
C
A
D
D
KEG
E
D
V
E
V
P
F
I
T
I
H
L
140
HHSearch
48.45
18%
-51
- C1 -
4GSL
1
ATG7_YEAST
A:
[311-535]
------------
M
K
--
W
R
I
---
L
--
P
D
---
L
N
L
D
I
I
K
N
T
K
V
L
L
L
G
A
G
T
L
G
C
Y
V
S
R
A
L
I
A
W
G
V
-----
R
K
I
T
F
V
D
N
G
T
V
S
Y
S
N
P
V
R
Q
A
L
Y
N
F
E
D
C
G
K
P
K
A
E
L
A
A
A
S
L
K
R
I
F
P
L
M
--
D
A
T
G
V
K
L
S
I
PMIGHKLVN
E
E
A
Q
H
K
D
---------------
F
-
D
R
L
----
R
A
L
I
-
K
-
E
H
D
I
I
F
L
L
V
D
S
--
R
-
E
S
R
W
L
P
S
L
L
S
N
I
------------
E
N
K
T
V
I
N
A
A
-
L
G
F
D
--
S
Y
L
V
M
R
H
G
N-------
K
Q
L
G
C
Y
F
C
H
D
V
V
A
P
T
D
----------------------------
S
L
T
-----
D
---------
R
T
--
L
D
Q
--
M
C
T
V
T
R
P
G
V
A
M
M
A
S
S
L
-
A
V
E
L
M
T
S
L
L
Q
T
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
47.51
22%
-121
- C1 -
4P22
-
UBA1_HUMAN
A:
[52-204]
-------
E
G
L
Y
S
R
Q
--
L
Y
V
---
L
--
G
H
---
E
A
M
K
R
L
Q
T
S
S
V
L
V
S
G
L
R
G
L
G
V
E
I
A
K
N
I
I
L
G
G
V
-----
K
A
V
T
L
H
D
Q
G
T
A
Q
W
A
D
L
S
S
Q
F
Y
L
R
E
E
D
I
G
K
N
R
A
E
V
S
Q
P
R
L
A
E
L
N
S
Y
V
--
P
V
T
A
Y
T
G
P
L
---------------
V
------------------------
E
D
F
L
-
S
-
G
F
Q
V
V
V
L
T
N
T
P
--
L
-
E
D
Q
L
R
V
G
E
F
C
H
N
------------
R
G
I
K
L
V
V
A
D
T
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
46.35
21%
-131
- C1 -
1TT5
2
UBA3_HUMAN
B:
[32-212]
--------------------------
E
---
S
L
Q
F
L
L
D
T
C
K
V
L
V
I
G
A
G
G
L
G
C
E
L
L
K
N
L
A
L
S
G
F
-----
R
Q
I
H
V
I
D
M
D
T
I
D
V
S
N
L
N
R
Q
F
L
F
R
P
K
D
I
G
R
P
K
A
E
V
A
A
E
F
L
N
D
R
V
P
N
C
--
N
V
V
P
H
F
N
K
I
---------------
Q
---------------
D
-
F
N
-----
D
T
F
Y
-
R
-
Q
F
H
I
I
V
C
G
L
D
S
--
I
-
I
A
R
R
W
I
N
G
M
L
I
S
L
L
N
Y
E
DGVLDPS
S
I
V
P
L
I
D
G
G
T
E
G
F
K
G
N
--
A
---
R
-----
V
I
L
P
G
M
T
A
C
I
E
C
T
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
46.18
23%
-17
- C1 -
4II2
5
UBA1_SCHPO
A:
[397-577]
--------
C
R
Y
D
G
Q
--
I
A
V
---
F
--
G
S
---
E
F
Q
E
K
I
A
S
L
S
T
F
L
V
G
A
G
A
I
G
C
E
M
L
K
N
W
A
M
M
G
V
ATGES
G
H
I
S
V
T
D
M
D
S
I
E
K
S
N
L
N
R
Q
F
L
F
R
P
R
D
V
G
K
L
K
S
E
C
A
S
T
A
V
S
I
M
N
P
S
L
TG
K
I
T
S
Y
Q
E
R
V
---------------
G
---------------
P
-
E
S
E
GIFG
D
E
F
F
-
E
-
K
L
S
L
V
T
N
A
L
D
N
--
V
-
E
A
R
M
Y
V
D
R
R
C
V
F
------------
F
E
K
P
L
L
E
S
G
T
L
G
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
HHSearch
46.03
21%
-136
* C1 *
2NVU
3
UBA3_HUMAN
B:
[402-568]
-------------------------
T
E
---
S
L
Q
F
L
L
D
T
C
K
V
L
V
I
G
A
G
G
L
G
C
E
L
L
K
N
L
A
L
S
G
F
-----
R
Q
I
H
V
I
D
M
D
T
I
D
V
S
N
L
N
R
Q
F
L
F
R
P
K
D
I
G
R
P
K
A
E
V
A
A
E
F
L
N
D
R
V
P
N
C
--
N
V
V
P
H
F
N
K
I
---------------
Q
---------------
D
-
F
N
-----
D
T
F
Y
-
R
-
Q
F
H
I
I
V
C
G
L
D
S
--
I
-
I
A
R
R
W
I
N
G
M
L
I
S
L
LNYEDGVLDPS
S
I
V
P
L
I
D
G
G
T
E
G
F
K
G
N
----
A
-
R
-----
V
I
L
P
G
M
T
A
C
I
E
C
T
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
45.71
18%
-40
- C1 -
3RUI
1
A:
[16-244]
--------
L
K
L
M
K
W
---
R
I
---
L
--
P
D
---
L
N
L
D
I
I
K
N
T
K
V
L
L
L
G
A
G
T
L
G
C
Y
V
S
R
A
L
I
A
W
G
V
-----
R
K
I
T
F
V
D
N
G
T
V
S
Y
S
N
P
V
R
Q
A
L
Y
N
F
E
D
C
G
K
P
K
A
E
L
A
A
A
S
L
K
R
I
F
P
L
M
--
D
A
T
G
V
K
L
S
I
---------------
P
MIGHKLVN
E
E
A
Q
H
K
D
F
-
D
R
L
----
R
A
L
I
-
K
-
E
H
D
I
I
F
L
L
V
D
S
--
R
-
E
S
R
W
L
P
S
L
L
S
N
I
------------
E
N
K
T
V
I
N
A
A
-
L
G
F
--
D
S
Y
L
-
V
M
R
H
G
N
R
D
E
Q
S
S
K
Q
L
G
C
Y
F
C
H
D
V
V
A
P
T
D
----------------------------
S
L
T
----------------
D
R
T
L
D
Q
--
M
S
T
V
T
R
P
G
V
A
M
M
A
S
S
L
-
A
V
E
L
M
T
S
L
L
Q
T
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
44.84
33%
0
- C- -
1JWA
1
MOEB_ECOLI
B:
[24-176]
------------------------------
D
G
Q
E
A
L
K
D
S
R
V
L
I
V
G
L
G
G
L
G
C
A
A
S
Q
Y
L
A
S
A
G
V
-----
G
N
L
T
L
L
D
F
D
T
V
S
L
S
N
L
Q
R
Q
T
L
H
S
D
A
T
V
G
Q
P
K
V
E
S
A
R
D
A
L
T
R
I
N
P
H
I
--
A
I
T
P
V
N
A
L
L
---------------
D
---------------
D
-
A
E
L
----
A
A
L
I
-
A
E
H
-
D
L
V
L
D
C
T
D
N
--
V
-
A
V
R
N
Q
L
N
A
G
C
F
A
------------
A
K
V
P
L
V
S
--
G
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------