@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu27710: (2016-07-13 )
MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLATVKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQVFSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYDYMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAIGGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTRIARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLRLTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF
Atome Classification :
(89 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180----.....----..190.......200.......210.......220....---...230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEQP
I
R
Y
E
F
I
K
E
C
K
Q
T
G
ARLGKVHTPHGSFET
P
V
F
M
PVG
T
L
A
T
V
KTM
S
P
E
E
L
K
A
MDA
G
I
I
L
SN
T
Y
H
L
W
LRP
G
Q
D
I
V
K
EAGG
L
H
K
F
MNWDR
A
I
LTDSGG
F
Q
V
F
S
L
S
K
FRNIEEEG
V
H
F
RNHLNG
D
K
L
F
LS
P
E
K
A
M
E
I
Q
N
ALG
S
D
I
M
M
A
F
DECPPYP
A
E
Y
D
Y
M
K
R
S
V
E
R
T
S
R
W
A
E
R
C
L
N
AHNR----QDEQG----
L
F
G
I
VQGGE
Y
E
D
L
R
T
QSAK
D
L
I
SLDFPG
Y
A
IGGLSVG
E
P
---
K
D
V
M
N
R
V
L
E
FTTPLLPKDKP
R
Y
L
M
GVGS
P
D
A
L
I
D
G
A
IRGV
D
M
F
D
CVL
P
T
R
IARNG
T
V
F
T
AE
G
R
LNMKNAKFERDFRPIDEEC
D
C
Y
T
C
K
N
Y
T
R
A
Y
I
R
H
L
I
RCNETF
G
L
R
L
T
T
Y
H
N
L
H
F
L
L
H
L
M
E
Q
V
R
Q
A
I
R
EDR
L
G
D
F
R
E
E
F
F
E
RYGYNKPNAKSF
111
HHSearch
92.35
51%
-102
- C5 -
2ASH
8
TGT_THEMA
A:
[13-375]
-----
M
E
F
E
V
K
K
T
--
F
G
K
A
R
L
G
V
M
K
L
H
H
G
A
V
E
T
P
V
F
M
P
V
G
T
N
A
S
V
K
L
L
T
P
R
D
L
E
E
A
G
A
E
I
I
L
S
N
T
F
H
L
M
L
K
P
G
V
E
I
I
K
L
H
R
G
L
H
N
F
M
G
W
K
R
P
I
L
T
D
S
G
G
F
Q
V
F
S
L
P
K
I
-
R
I
D
D
E
G
V
V
F
R
S
P
I
D
G
S
K
V
F
L
N
P
E
I
S
M
E
V
Q
I
A
L
G
S
D
I
C
M
V
F
D
H
C
P
V
--
A
D
Y
E
E
V
K
E
A
T
E
R
T
Y
R
W
A
L
R
S
K
K
A
F
K
T
-----
E
N
Q
A
----
L
F
G
I
V
Q
G
G
I
Y
P
D
L
R
R
E
S
A
L
Q
L
T
S
I
G
F
D
G
Y
A
I
G
G
L
S
I
G
E
E
---
R
S
L
T
L
E
M
T
E
V
T
V
E
F
L
P
E
D
K
P
R
Y
F
M
G
G
G
S
P
E
L
I
L
E
L
V
D
R
G
V
D
M
F
D
S
V
F
P
T
R
I
A
R
H
G
T
A
L
T
W
N
G
K
L
N
L
K
A
S
Y
N
K
R
S
L
E
P
V
D
E
R
C
G
C
Y
T
C
K
N
F
T
R
S
Y
I
H
H
L
F
D
R
G
E
V
L
G
Q
I
L
L
T
I
H
N
I
N
F
M
I
S
L
M
K
E
V
R
R
S
I
E
S
G
T
F
K
E
L
K
S
K
V
V
E
V
Y
S
---------
57
PsiBlast_CBE
86.81
52%
-37
- C5 -
1Q2S
2
TGT_ZYMMO
B:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
55
PsiBlast_CBE
86.16
52%
-37
- C5 -
1Q2S
3
TGT_ZYMMO
D:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
58
PsiBlast_CBE
85.54
52%
-36
- C5 -
1Q2R
3
TGT_ZYMMO
D:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
83
PsiBlast_CBE
85.43
51%
-39
- C5 -
1WKE
1
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
A
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
12
PsiBlast_PDB
85.41
52%
-37
- C5 -
1N2V
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
20
PsiBlast_PDB
85.35
52%
-39
- C5 -
1S39
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
60
PsiBlast_CBE
85.32
52%
-35
- C5 -
1Q2R
3
TGT_ZYMMO
B:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
8
PsiBlast_PDB
85.17
52%
-36
- C5 -
1ENU
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
89
PsiBlast_CBE
85.03
51%
-38
- C5 -
4JBR
2
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
C
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
9
PsiBlast_PDB
85.02
52%
-35
- C5 -
1F3E
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
56
PsiBlast_CBE
84.83
52%
-34
- C5 -
1Q2S
3
TGT_ZYMMO
C:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
14
PsiBlast_PDB
84.83
52%
-33
- C5 -
1Q2S
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
10
PsiBlast_PDB
84.78
52%
-37
- C5 -
1K4G
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
110
HHSearch
84.69
51%
-35
* C5 *
4Q8W
6
TGT_ZYMMO
A:
[12-385]
-
D
R
P
R
F
S
F
S
I
A
A
R
--
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
-
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
--------
78
PsiBlast_CBE
84.66
52%
-39
- C5 -
4GD0
6
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
59
PsiBlast_CBE
84.66
52%
-36
- C5 -
1Q2R
3
TGT_ZYMMO
C:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
63
PsiBlast_CBE
84.63
51%
-38
- C5 -
1EFZ
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
A
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
2
PsiBlast_PDB
84.59
52%
-33
- C5 -
1OZQ
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
91
PsiBlast_CBE
84.56
51%
-38
- C5 -
1WKF
1
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
Y
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
82
PsiBlast_CBE
84.49
51%
-35
- C5 -
4DXX
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
--
T
V
M
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
11
PsiBlast_PDB
84.41
52%
-37
- C5 -
1K4H
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
77
PsiBlast_CBE
84.29
52%
-34
- C5 -
4H7Z
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
21
PsiBlast_CBE
84.23
52%
-35
- C5 -
4LEQ
5
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
-
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
13
PsiBlast_PDB
84.23
52%
-36
- C5 -
1Q2R
3
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
102
Fugue
84.17
51%
-33
- C5 -
1K4G
2
TGT_ZYMMO
A:
[11-382]
----
R
P
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
---GEG
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
---------
31
PsiBlast_CBE
84.17
52%
-38
- C5 -
4Q4O
6
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
28
PsiBlast_CBE
84.16
52%
-41
- C5 -
4Q4R
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
70
PsiBlast_CBE
84.14
51%
-34
- C5 -
4Q8M
9
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
32
PsiBlast_CBE
84.14
52%
-40
- C5 -
4Q4M
6
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
30
PsiBlast_CBE
84.11
52%
-41
- C5 -
4Q4P
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
65
PsiBlast_CBE
84.09
51%
-36
- C5 -
2Z1W
11
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
52
PsiBlast_CBE
83.95
52%
-35
- C5 -
2QII
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
87
PsiBlast_CBE
83.91
51%
-32
- C5 -
4IPP
6
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
D
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
6
PsiBlast_PDB
83.89
52%
-37
- C5 -
1Y5X
2
TGT_ZYMMO
A:
[12-380]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
4
PsiBlast_PDB
83.79
52%
-36
- C5 -
4Q8W
6
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
-
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
68
PsiBlast_CBE
83.59
51%
-39
- C5 -
2OKO
17
TGT_ZYMMO
A:
[12-380]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
73
PsiBlast_CBE
83.52
51%
-42
- C5 -
1PXG
10
TGT_ZYMMO
A:
[12-380]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
E
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
79
PsiBlast_CBE
83.51
52%
-35
- C5 -
4E2V
6
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
------
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
19
PsiBlast_PDB
83.47
52%
-38
- C5 -
1S38
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
22
PsiBlast_CBE
83.43
52%
-37
- C5 -
4LBU
6
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
3
PsiBlast_PDB
83.43
52%
-35
- C5 -
4Q8V
3
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
39
PsiBlast_CBE
83.39
52%
-39
- C5 -
4GH3
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
-----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
92
PsiBlast_CBE
83.32
51%
-33
- C5 -
4HQV
6
TGT_ZYMMO
A:
[12-380]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
54
PsiBlast_CBE
83.30
52%
-38
- C5 -
2BBF
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
76
PsiBlast_CBE
83.25
52%
-40
- C5 -
4HVX
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-------
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
80
PsiBlast_CBE
83.24
51%
-40
- C5 -
4PUL
3
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
N
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
86
PsiBlast_CBE
83.23
51%
-41
- C5 -
4L56
8
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
D
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
71
PsiBlast_CBE
83.21
51%
-36
- C5 -
4PUM
4
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
N
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
85
PsiBlast_CBE
83.17
51%
-33
- C5 -
4Q8P
5
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
D
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
--
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
26
PsiBlast_CBE
83.16
52%
-34
- C5 -
4Q8T
6
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
35
PsiBlast_CBE
83.11
52%
-35
- C5 -
4PUJ
7
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
--
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
25
PsiBlast_CBE
83.10
52%
-35
- C5 -
4Q8U
9
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
94
PsiBlast_CBE
83.05
51%
-32
- C5 -
4GCX
6
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
----
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
64
PsiBlast_CBE
83.03
51%
-37
- C5 -
2Z1X
10
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
-------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
45
PsiBlast_CBE
83.01
52%
-37
- C5 -
3RR4
4
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
16
PsiBlast_PDB
82.96
52%
-37
- C5 -
1P0E
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
81
PsiBlast_CBE
82.95
51%
-45
- C5 -
4Q8Q
2
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
C
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
66
PsiBlast_CBE
82.90
51%
-37
- C5 -
2PWV
8
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
53
PsiBlast_CBE
82.86
52%
-39
- C5 -
2PWU
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
---
K
Q
S
E
E
G
V
T
F
K
S
-------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
-----
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
18
PsiBlast_PDB
82.81
52%
-40
- C5 -
1Q66
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
---
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
40
PsiBlast_CBE
82.78
52%
-37
- C5 -
4GH1
3
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
------
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
34
PsiBlast_CBE
82.76
52%
-35
- C5 -
4PUK
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
29
PsiBlast_CBE
82.69
52%
-38
- C5 -
4Q4Q
6
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
27
PsiBlast_CBE
82.69
52%
-35
- C5 -
4Q4S
6
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
--
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
88
PsiBlast_CBE
82.62
52%
-35
- C5 -
2NQZ
8
TGT_ZYMMO
A:
[12-380]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-------
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
S
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
46
PsiBlast_CBE
82.62
52%
-38
- C5 -
3GE7
4
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
44
PsiBlast_CBE
82.59
52%
-36
- C5 -
3SM0
4
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
51
PsiBlast_CBE
82.53
52%
-32
- C5 -
3C2Y
7
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
36
PsiBlast_CBE
82.53
52%
-37
- C5 -
4GKT
3
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
17
PsiBlast_PDB
82.52
52%
-37
- C5 -
1Q63
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
69
PsiBlast_CBE
82.40
51%
-36
- C5 -
4Q8O
6
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
47
PsiBlast_CBE
82.40
52%
-37
- C5 -
3GC5
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
5
PsiBlast_PDB
82.38
52%
-38
- C5 -
1Y5V
4
TGT_ZYMMO
A:
[12-380]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
72
PsiBlast_CBE
82.36
52%
-36
- C5 -
4HSH
9
TGT_ZYMMO
A:
[12-380]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
----
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
93
PsiBlast_CBE
82.22
51%
-38
- C5 -
4H6E
8
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
-
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
49
PsiBlast_CBE
82.19
52%
-46
- C5 -
3EOU
4
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
7
PsiBlast_PDB
82.13
52%
-37
- C5 -
2QZR
4
TGT_ZYMMO
A:
[12-380]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-----
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
43
PsiBlast_CBE
82.07
52%
-36
- C5 -
3TLL
5
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
50
PsiBlast_CBE
81.95
52%
-42
- C5 -
3EOS
4
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
-----
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
67
PsiBlast_CBE
81.94
51%
-38
- C5 -
2POT
9
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
-----------
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
38
PsiBlast_CBE
81.85
52%
-37
- C5 -
4GI4
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
23
PsiBlast_CBE
80.99
52%
-40
- C5 -
4KWO
3
TGT_ZYMMO
A:
[15-383]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
-------------
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
48
PsiBlast_CBE
80.85
52%
-33
- C5 -
3GC4
7
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
----------
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
24
PsiBlast_CBE
79.85
52%
-37
- C5 -
1Y5X
2
TGT_ZYMMO
D:
[12-380]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
---------------
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
ENAA
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
41
PsiBlast_CBE
79.74
52%
-40
- C5 -
4FR6
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
----
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
74
PsiBlast_CBE
79.67
52%
-35
- C5 -
3BLD
4
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
------
Q
S
E
E
G
V
T
F
K
S
--------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
----------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
37
PsiBlast_CBE
79.08
52%
-35
- C5 -
4GIY
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------
42
PsiBlast_CBE
78.71
52%
-40
- C5 -
4FR1
2
TGT_ZYMMO
A:
[13-381]
------
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
-----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
-
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
----------