@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28200: (2016-07-14 )
MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMHDHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYNEHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEPGRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRYEKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILEYLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSFSDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPKQIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRITVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITMATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEKDIEDIPESVREGLTFILASHLDEVLEHALVGEKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340----...----....350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......--560-....-...570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770..-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
E
E
L
K
R
SIPLLPLRG
L
L
VY
P
T
M
V
L
H
L
DVGRD
K
S
V
Q
A
L
E
Q
A
M
M
HD
H
M
I
F
L
A
TQQDISIDEPGED
E
I
F
T
VG
T
Y
T
K
I
K
Q
M
L
KLPN
G
T
I
R
V
L
V
E
G
L
K
R
A
H
I
V
K
YNEHEDY
T
S
V
D
I
Q
L
I
HEDDSKD
T
E
D
E
A
L
M
R
T
L
L
D
H
F
D
Q
Y
I
K
I
S
K
KISA
E
T
Y
A
A
VTDIEEPG
R
M
A
D
I
V
A
SHL
P
L
KLK
D
K
Q
D
I
L
E
T
A
D
V
K
D
R
L
N
K
V
I
D
F
INN
E
K
E
V
L
E
I
E
K
K
I
G
Q
R
V
K
R
S
M
E
R
T
Q
K
E
Y
Y
L
R
E
Q
M
K
A
I
Q
K
E
LGDKEGKTG
E
V
Q
T
L
T
E
K
I
E
EAGM
P
D
H
V
K
E
T
A
L
K
E
L
N
R
Y
E
KIPSSS
A
E
S
S
V
I
R
N
Y
I
D
W
L
VALPWTDETDDKL
D
L
K
E
A
G
R
L
L
D
E
EHH
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
----
K
SL----KG
P
I
L
C
LAGPPGV
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
LGGVR
D
E
S
E
IRGHRRTYVGAM
P
G
R
I
I
Q
G
M
K
K
AGKLN
P
V
F
L
L
D
E
I
D
K
M
S
SDFRGD
P
S
S
A
M
L
E
VLDPEQNSSF
S
D
H
Y
I
E
E
TFDL
S
K
V
L
F
I
A
TANNLATIPG
P
L
R
D
R
M
E
I
INIAGY
T
E
I
E
K
L
E
I
V
K
D
HL
L
P
K
Q
I
K
E
HGLKKSN
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
--
A
E
E-RK
R
I
-
T
V
T
E
K
N
L
Q
D
F
I
G
K
R
I
F
RYGQAETEDQ
V
G
V
V
T
G
L
A
Y
T
TVGG
D
T
L
S
I
E
V
S
LSPGK
G
K
L
I
L
TG
K
L
G
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
K
T
E
ELGIEPDFH
E
K
Y
D
I
H
I
HVPEGAVPKDGPSA
G
I
T
M
A
T
A
L
V
S
A
L
TGR
A
V
S
R
EVGM
T
G
E
I
T
L
R
G
R
V
L
PIGG
L
K
E
K
ALGAHRAG
L
T
T
I
IAPKDNE
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
LVGEKK-----
102
HHSearch
80.68
100%
-108
- C4 -
3M6A
1
LON1_BACSU
A:
[7-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
V
Q
T
L
T
E
K
I
E
E
A
G
M
P
D
H
V
K
E
T
A
L
K
E
L
N
R
Y
E
K
I
P
S
S
S
A
E
S
S
V
I
R
N
Y
I
D
W
L
V
A
L
P
W
T
D
E
T
D
D
K
L
D
L
K
E
A
G
R
L
L
D
E
E
H
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
----
K
S
L
----
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
L
G
--------------------
G
R
I
I
Q
G
M
K
K
A
G
K
L
N
P
V
F
L
L
D
E
I
D
K
M
S
---------
A
M
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
A
T
A
N
N
L
A
T
I
P
G
P
L
R
D
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
D
H
L
L
P
K
Q
I
K
E
H
G
L
K
K
S
N
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
--
A
E
E
-
R
K
R
I
-
T
V
T
E
K
N
L
Q
D
F
I
G
K
R
I
F
R
Y
G
Q
A
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
T
V
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
K
L
G
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
K
T
E
E
L
G
I
E
P
D
F
H
E
K
Y
D
I
H
I
H
V
P
E
G
A
V
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
L
V
---------
123
Fugue
80.47
99%
-108
- C4 -
3M6A
1
LON1_BACSU
A:
[7-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
V
Q
T
L
T
E
K
I
E
E
A
G
M
P
D
H
V
K
E
T
A
L
K
E
L
N
R
Y
E
K
I
P
S
S
S
A
E
S
S
V
I
R
N
Y
I
D
W
L
V
A
L
P
W
T
D
E
T
D
D
K
L
D
L
K
E
A
G
R
L
L
D
E
E
H
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
----
K
S
L
----
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
L
G
G
--------------------
R
I
I
Q
G
M
K
K
A
G
K
L
N
P
V
F
L
L
D
E
I
D
K
M
S
---------
A
M
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
A
T
A
N
N
L
A
T
I
P
G
P
L
R
D
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
D
H
L
L
P
K
Q
I
K
E
H
G
L
K
K
S
N
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
--
A
E
E
-
R
K
R
I
-
T
V
T
E
K
N
L
Q
D
F
I
G
K
R
I
F
R
Y
G
Q
A
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
T
V
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
K
L
G
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
K
T
E
E
L
G
I
E
P
D
F
H
E
K
Y
D
I
H
I
H
V
P
E
G
A
V
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
L
V
---------
1
PsiBlast_PDB
80.47
99%
-108
- C4 -
3M6A
1
LON1_BACSU
A:
[7-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
V
Q
T
L
T
E
K
I
E
E
A
G
M
P
D
H
V
K
E
T
A
L
K
E
L
N
R
Y
E
K
I
P
S
S
S
A
E
S
S
V
I
R
N
Y
I
D
W
L
V
A
L
P
W
T
D
E
T
D
D
K
L
D
L
K
E
A
G
R
L
L
D
E
E
H
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
----
K
S
L
----
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
L
G
--------------------
G
R
I
I
Q
G
M
K
K
A
G
K
L
N
P
V
F
L
L
D
E
I
D
K
M
S
---------
A
M
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
A
T
A
N
N
L
A
T
I
P
G
P
L
R
D
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
D
H
L
L
P
K
Q
I
K
E
H
G
L
K
K
S
N
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
--
A
E
E
-
R
K
R
I
-
T
V
T
E
K
N
L
Q
D
F
I
G
K
R
I
F
R
Y
G
Q
A
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
T
V
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
K
L
G
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
K
T
E
E
L
G
I
E
P
D
F
H
E
K
Y
D
I
H
I
H
V
P
E
G
A
V
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
L
V
---------
22
PsiBlast_CBE
80.40
99%
-106
- C4 -
3M6A
1
LON1_BACSU
E:
[7-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
V
Q
T
L
T
E
K
I
E
E
A
G
M
P
D
H
V
K
E
T
A
L
K
E
L
N
R
Y
E
K
I
P
S
S
S
A
E
S
S
V
I
R
N
Y
I
D
W
L
V
A
L
P
W
T
D
E
T
D
D
K
L
D
L
K
E
A
G
R
L
L
D
E
E
H
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
----
K
S
L
----
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
L
G
--------------------
G
R
I
I
Q
G
M
K
K
A
G
K
L
N
P
V
F
L
L
D
E
I
D
K
M
S
---------
A
M
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
A
T
A
N
N
L
A
T
I
P
G
P
L
R
D
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
D
H
L
L
P
K
Q
I
K
E
H
G
L
K
K
S
N
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
--
A
E
E
-
R
K
R
I
-
T
V
T
E
K
N
L
Q
D
F
I
G
K
R
I
F
R
Y
G
Q
A
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
T
V
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
K
L
G
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
K
T
E
E
L
G
I
E
P
D
F
H
E
K
Y
D
I
H
I
H
V
P
E
G
A
V
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
L
V
---------
23
PsiBlast_CBE
80.21
99%
-107
- C4 -
3M6A
1
LON1_BACSU
D:
[7-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
V
Q
T
L
T
E
K
I
E
E
A
G
M
P
D
H
V
K
E
T
A
L
K
E
L
N
R
Y
E
K
I
P
S
S
S
A
E
S
S
V
I
R
N
Y
I
D
W
L
V
A
L
P
W
T
D
E
T
D
D
K
L
D
L
K
E
A
G
R
L
L
D
E
E
H
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
----
K
S
L
----
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
L
G
--------------------
G
R
I
I
Q
G
M
K
K
A
G
K
L
N
P
V
F
L
L
D
E
I
D
K
M
S
---------
A
M
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
A
T
A
N
N
L
A
T
I
P
G
P
L
R
D
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
D
H
L
L
P
K
Q
I
K
E
H
G
L
K
K
S
N
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
--
A
E
E
-
R
K
R
I
-
T
V
T
E
K
N
L
Q
D
F
I
G
K
R
I
F
R
Y
G
Q
A
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
T
V
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
K
L
G
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
K
T
E
E
L
G
I
E
P
D
F
H
E
K
Y
D
I
H
I
H
V
P
E
G
A
V
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
L
V
---------
24
PsiBlast_CBE
80.16
99%
-107
- C4 -
3M6A
1
LON1_BACSU
C:
[7-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
V
Q
T
L
T
E
K
I
E
E
A
G
M
P
D
H
V
K
E
T
A
L
K
E
L
N
R
Y
E
K
I
P
S
S
S
A
E
S
S
V
I
R
N
Y
I
D
W
L
V
A
L
P
W
T
D
E
T
D
D
K
L
D
L
K
E
A
G
R
L
L
D
E
E
H
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
----
K
S
L
----
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
L
G
--------------------
G
R
I
I
Q
G
M
K
K
A
G
K
L
N
P
V
F
L
L
D
E
I
D
K
M
S
---------
A
M
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
A
T
A
N
N
L
A
T
I
P
G
P
L
R
D
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
D
H
L
L
P
K
Q
I
K
E
H
G
L
K
K
S
N
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
--
A
E
E
-
R
K
R
I
-
T
V
T
E
K
N
L
Q
D
F
I
G
K
R
I
F
R
Y
G
Q
A
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
T
V
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
K
L
G
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
K
T
E
E
L
G
I
E
P
D
F
H
E
K
Y
D
I
H
I
H
V
P
E
G
A
V
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
L
V
---------
25
PsiBlast_CBE
79.92
99%
-105
- C4 -
3M6A
1
LON1_BACSU
B:
[7-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
V
Q
T
L
T
E
K
I
E
E
A
G
M
P
D
H
V
K
E
T
A
L
K
E
L
N
R
Y
E
K
I
P
S
S
S
A
E
S
S
V
I
R
N
Y
I
D
W
L
V
A
L
P
W
T
D
E
T
D
D
K
L
D
L
K
E
A
G
R
L
L
D
E
E
H
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
----
K
S
L
----
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
L
G
--------------------
G
R
I
I
Q
G
M
K
K
A
G
K
L
N
P
V
F
L
L
D
E
I
D
K
M
S
---------
A
M
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
A
T
A
N
N
L
A
T
I
P
G
P
L
R
D
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
D
H
L
L
P
K
Q
I
K
E
H
G
L
K
K
S
N
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
--
A
E
E
-
R
K
R
I
-
T
V
T
E
K
N
L
Q
D
F
I
G
K
R
I
F
R
Y
G
Q
A
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
T
V
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
K
L
G
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
K
T
E
E
L
G
I
E
P
D
F
H
E
K
Y
D
I
H
I
H
V
P
E
G
A
V
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
L
V
---------
21
PsiBlast_CBE
79.90
99%
-108
- C4 -
3M6A
1
LON1_BACSU
F:
[7-531]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
V
Q
T
L
T
E
K
I
E
E
A
G
M
P
D
H
V
K
E
T
A
L
K
E
L
N
R
Y
E
K
I
P
S
S
S
A
E
S
S
V
I
R
N
Y
I
D
W
L
V
A
L
P
W
T
D
E
T
D
D
K
L
D
L
K
E
A
G
R
L
L
D
E
E
H
H
G
L
E
K
V
K
E
R
I
L
E
Y
L
A
V
Q
K
L
T
----
K
S
L
----
K
G
P
I
L
C
L
A
G
P
P
G
V
G
K
T
S
L
A
K
S
I
A
K
S
L
G
R
K
F
V
R
I
S
L
G
--------------------
G
R
I
I
Q
G
M
K
K
A
G
K
L
N
P
V
F
L
L
D
E
I
D
K
M
S
---------
A
M
L
E
V
L
D
P
E
Q
N
S
S
F
S
D
H
Y
I
E
E
T
F
D
L
S
K
V
L
F
I
A
T
A
N
N
L
A
T
I
P
G
P
L
R
D
R
M
E
I
I
N
I
A
G
Y
T
E
I
E
K
L
E
I
V
K
D
H
L
L
P
K
Q
I
K
E
H
G
L
K
K
S
N
L
Q
L
R
D
Q
A
I
L
D
I
I
R
Y
Y
T
R
E
A
G
V
R
S
L
E
R
Q
L
A
A
I
C
R
K
A
A
K
A
I
V
--
A
E
E
-
R
K
R
I
-
T
V
T
E
K
N
L
Q
D
F
I
G
K
R
I
F
R
Y
G
Q
A
E
T
E
D
Q
V
G
V
V
T
G
L
A
Y
T
T
V
G
G
D
T
L
S
I
E
V
S
L
S
P
G
K
G
K
L
I
L
T
G
K
L
G
D
V
M
R
E
S
A
Q
A
A
F
S
Y
V
R
S
K
T
E
E
L
G
I
E
P
D
F
H
E
K
Y
D
I
H
I
H
V
P
E
G
A
V
P
K
D
G
P
A
A
G
I
T
M
A
T
A
L
V
S
A
L
T
G
R
A
V
S
R
E
V
G
M
T
G
E
I
T
L
R
G
R
V
L
P
I
G
G
L
K
E
K
A
L
G
A
H
R
A
G
L
T
T
I
I
A
P
K
D
N
E
K
D
I
E
D
I
P
E
S
V
R
E
G
L
T
F
I
L
A
S
H
L
D
E
V
L
E
H
A
L
V
---------
30
PsiBlast_CBE
65.09
56%
9
- C4 -
4YPL
2
?
B:
[7-535]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
A
L
R
K
K
I
E
E
V
G
M
P
E
A
V
K
T
K
A
L
K
E
L
D
R
L
E
R
M
Q
Q
G
S
P
E
A
T
V
A
R
T
Y
L
D
W
L
T
E
V
P
W
S
K
A
D
P
E
V
L
D
I
N
H
T
R
Q
V
L
D
E
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
L
T
----
Q
G
L
DVRN
K
A
P
I
L
V
L
V
G
P
P
G
V
G
K
T
S
L
G
R
S
I
A
R
S
M
N
R
K
F
H
R
I
S
L
G
G
V
R
D
E
A
E
I
R
G
H
R
R
T
Y
I
G
A
M
P
G
K
L
I
H
A
M
K
Q
V
G
V
I
N
P
V
I
L
L
D
Q
I
D
K
M
S
S
D
W
R
G
D
P
A
S
A
M
L
E
V
L
D
P
E
Q
N
N
T
F
T
D
H
Y
L
D
V
P
Y
D
L
S
K
V
F
F
I
T
T
A
N
T
L
Q
T
I
P
R
P
L
L
D
R
M
E
V
I
E
I
P
G
Y
T
N
M
E
K
Q
A
I
A
R
Q
Y
L
W
P
K
Q
V
R
E
S
G
M
-
E
G
R
I
E
V
T
D
A
A
I
L
R
V
I
S
E
Y
T
R
E
A
G
V
R
G
L
E
R
E
L
G
K
I
A
R
K
G
A
K
F
W
L
EG
A
W
E
-
G
L
R
--
T
I
D
A
S
D
I
P
T
Y
L
G
I
P
R
Y
R
P
D
K
A
E
T
E
P
Q
V
G
T
A
Q
G
L
A
W
T
P
V
G
G
T
L
L
T
I
E
V
A
A
V
P
G
S
G
K
L
S
L
T
G
Q
L
G
E
V
M
K
E
S
A
Q
A
A
L
T
Y
L
R
A
H
T
Q
D
Y
G
L
P
E
D
F
Y
N
K
V
D
L
H
V
H
V
P
D
G
A
T
P
K
D
G
P
S
A
G
I
T
M
A
T
A
I
A
S
A
L
S
R
R
P
A
R
M
D
I
A
M
T
G
E
V
S
L
R
G
K
V
M
P
I
G
G
V
K
E
K
L
L
A
A
H
Q
A
G
I
H
K
I
V
L
P
K
D
N
E
A
Q
L
E
E
L
P
K
E
V
L
E
G
L
E
I
K
L
V
E
D
V
G
E
V
L
E
Y
L
L
L
P
E
-------
103
HHSearch
64.67
57%
10
- C4 -
4YPL
1
?
A:
[6-535]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
E
A
L
R
K
K
I
E
E
V
G
M
P
E
A
V
K
T
K
A
L
K
E
L
D
R
L
E
R
M
Q
Q
G
S
P
E
A
T
V
A
R
T
Y
L
D
W
L
T
E
V
P
W
S
K
A
D
P
E
V
L
D
I
N
H
T
R
Q
V
L
D
E
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
L
T
QGLD
V
R
N
----
K
A
P
I
L
V
L
V
G
P
P
G
V
G
K
T
S
L
G
R
S
I
A
R
S
M
N
R
K
F
H
R
I
S
L
G
G
V
R
D
E
A
E
I
R
G
H
R
R
T
Y
I
G
A
M
P
G
K
L
I
H
A
M
K
Q
V
G
V
I
N
P
V
I
L
L
D
Q
I
D
K
M
S
S
D
W
R
G
D
P
A
S
A
M
L
E
V
L
D
P
E
Q
N
N
T
F
T
D
H
Y
L
D
V
P
Y
D
L
S
K
V
F
F
I
T
T
A
N
T
L
Q
T
I
P
R
P
L
L
D
R
M
E
V
I
E
I
P
G
Y
T
N
M
E
K
Q
A
I
A
R
Q
Y
L
W
P
K
Q
V
R
E
S
G
M
E
G
-
R
I
E
V
T
D
A
A
I
L
R
V
I
S
E
Y
T
R
E
A
G
V
R
G
L
E
R
E
L
G
K
I
A
R
K
G
A
K
F
W
L
--
E
G
A
W
E
G
L
R
-
T
I
D
A
S
D
I
P
T
Y
L
G
I
P
R
Y
R
P
D
K
A
E
T
E
P
Q
V
G
T
A
Q
G
L
A
W
T
P
V
G
G
T
L
L
T
I
E
V
A
A
V
P
G
S
G
K
L
S
L
T
G
Q
L
G
E
V
M
K
E
S
A
Q
A
A
L
T
Y
L
R
A
H
T
Q
D
Y
G
L
P
E
D
F
Y
N
K
V
D
L
H
V
H
V
P
D
G
A
T
P
K
D
G
P
S
A
G
I
T
M
A
T
A
I
A
S
A
L
S
R
R
P
A
R
M
D
I
A
M
T
G
E
V
S
L
R
G
K
V
M
P
I
G
G
V
K
E
K
L
L
A
A
H
Q
A
G
I
H
K
I
V
L
P
K
D
N
E
A
Q
L
E
E
L
P
K
E
V
L
E
G
L
E
I
K
L
V
E
D
V
G
E
V
L
E
Y
L
L
L
P
E
-------
2
PsiBlast_PDB
63.95
56%
13
- C4 -
4YPL
1
?
A:
[7-535]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
A
L
R
K
K
I
E
E
V
G
M
P
E
A
V
K
T
K
A
L
K
E
L
D
R
L
E
R
M
Q
Q
G
S
P
E
A
T
V
A
R
T
Y
L
D
W
L
T
E
V
P
W
S
K
A
D
P
E
V
L
D
I
N
H
T
R
Q
V
L
D
E
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
L
T
----
Q
G
L
DVRN
K
A
P
I
L
V
L
V
G
P
P
G
V
G
K
T
S
L
G
R
S
I
A
R
S
M
N
R
K
F
H
R
I
S
L
G
G
V
R
D
E
A
E
I
R
G
H
R
R
T
Y
I
G
A
M
P
G
K
L
I
H
A
M
K
Q
V
G
V
I
N
P
V
I
L
L
D
Q
I
D
K
M
S
S
D
W
R
G
D
P
A
S
A
M
L
E
V
L
D
P
E
Q
N
N
T
F
T
D
H
Y
L
D
V
P
Y
D
L
S
K
V
F
F
I
T
T
A
N
T
L
Q
T
I
P
R
P
L
L
D
R
M
E
V
I
E
I
P
G
Y
T
N
M
E
K
Q
A
I
A
R
Q
Y
L
W
P
K
Q
V
R
E
S
G
M
-
E
G
R
I
E
V
T
D
A
A
I
L
R
V
I
S
E
Y
T
R
E
A
G
V
R
G
L
E
R
E
L
G
K
I
A
R
K
G
A
K
F
W
L
E
G
A
W
E
-
G
L
R
--
T
I
D
A
S
D
I
P
T
Y
L
G
I
P
R
Y
R
P
D
K
A
E
T
E
P
Q
V
G
T
A
Q
G
L
A
W
T
P
V
G
G
T
L
L
T
I
E
V
A
A
V
P
G
S
G
K
L
S
L
T
G
Q
L
G
E
V
M
K
E
S
A
Q
A
A
L
T
Y
L
R
A
H
T
Q
D
Y
G
L
P
E
D
F
Y
N
K
V
D
L
H
V
H
V
P
D
G
A
T
P
K
D
G
P
S
A
G
I
T
M
A
T
A
I
A
S
A
L
S
R
R
P
A
R
M
D
I
A
M
T
G
E
V
S
L
R
G
K
V
M
P
I
G
G
V
K
E
K
L
L
A
A
H
Q
A
G
I
H
K
I
V
L
P
K
D
N
E
A
Q
L
E
E
L
P
K
E
V
L
E
G
L
E
I
K
L
V
E
D
V
G
E
V
L
E
Y
L
L
L
P
E
-------
122
Fugue
63.90
56%
17
- C4 -
4YPL
1
?
C:
[5-542]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
D
L
E
A
L
R
K
K
I
E
E
V
G
M
P
E
A
V
K
T
K
A
L
K
E
L
D
R
L
E
R
M
Q
Q
G
S
P
E
A
T
V
A
R
T
Y
L
D
W
L
T
E
V
P
W
S
K
A
D
P
E
V
L
D
I
N
H
T
R
Q
V
L
D
E
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
L
T
----
Q
G
L
DVRN
K
A
P
I
L
V
L
V
G
P
P
G
V
G
K
T
S
L
G
R
S
I
A
R
S
M
N
R
K
F
H
R
I
S
L
G
G
V
R
D
E
A
E
I
R
G
H
R
R
T
Y
I
G
A
M
P
G
K
L
I
H
A
M
K
Q
V
G
V
I
N
P
V
I
L
L
D
Q
I
D
K
M
S
S
D
W
R
G
D
P
A
S
A
M
L
E
V
L
D
P
E
Q
N
N
T
F
T
D
H
Y
L
D
V
P
Y
D
L
S
K
V
F
F
I
T
T
A
N
T
L
Q
T
I
P
R
P
L
L
D
R
M
E
V
I
E
I
P
G
Y
T
N
M
E
K
Q
A
I
A
R
Q
Y
L
W
P
K
Q
V
R
E
S
G
M
E
-
G
R
I
E
V
T
D
A
A
I
L
R
V
I
S
E
Y
T
R
E
A
G
V
R
G
L
E
R
E
L
G
K
I
A
R
K
G
A
K
F
W
L
--
E
G
A
-
W
E
G
L
R
T
I
D
A
S
D
I
P
T
Y
L
G
I
P
R
Y
R
P
D
K
A
E
T
E
P
Q
V
G
T
A
Q
G
L
A
W
T
P
V
G
G
T
L
L
T
I
E
V
A
A
V
P
G
S
G
K
L
S
L
T
G
Q
L
G
E
V
M
K
E
S
A
Q
A
A
L
T
Y
L
R
A
H
T
Q
D
Y
G
L
P
E
D
F
Y
N
K
V
D
L
H
V
H
V
P
D
G
A
T
P
K
D
G
P
S
A
G
I
T
M
A
T
A
I
A
S
A
L
S
R
R
P
A
R
M
D
I
A
M
T
G
E
V
S
L
R
G
K
V
M
P
I
G
G
V
K
E
K
L
L
A
A
H
Q
A
G
I
H
K
I
V
L
P
K
D
N
E
A
Q
L
E
E
L
P
K
E
V
L
E
G
L
E
I
K
L
V
E
D
V
G
E
V
L
E
Y
L
L
L
P
E
P
T
MPPVV
28
PsiBlast_CBE
63.86
56%
14
- C4 -
4YPL
2
?
D:
[7-535]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
A
L
R
K
K
I
E
E
V
G
M
P
E
A
V
K
T
K
A
L
K
E
L
D
R
L
E
R
M
Q
Q
G
S
P
E
A
T
V
A
R
T
Y
L
D
W
L
T
E
V
P
W
S
K
A
D
P
E
V
L
D
I
N
H
T
R
Q
V
L
D
E
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
L
T
----
Q
G
L
DVRN
K
A
P
I
L
V
L
V
G
P
P
G
V
G
K
T
S
L
G
R
S
I
A
R
S
M
N
R
K
F
H
R
I
S
L
G
G
V
R
D
E
A
E
I
R
G
H
R
R
T
Y
I
G
A
M
P
G
K
L
I
H
A
M
K
Q
V
G
V
I
N
P
V
I
L
L
D
Q
I
D
K
M
S
S
D
W
R
G
D
P
A
S
A
M
L
E
V
L
D
P
E
Q
N
N
T
F
T
D
H
Y
L
D
V
P
Y
D
L
S
K
V
F
F
I
T
T
A
N
T
L
Q
T
I
P
R
P
L
L
D
R
M
E
V
I
E
I
P
G
Y
T
N
M
E
K
Q
A
I
A
R
Q
Y
L
W
P
K
Q
V
R
E
S
G
M
-
E
G
R
I
E
V
T
D
A
A
I
L
R
V
I
S
E
Y
T
R
E
A
G
V
R
G
L
E
R
E
L
G
K
I
A
R
K
G
A
K
F
W
L
EG
A
W
E
-
G
L
R
--
T
I
D
A
S
D
I
P
T
Y
L
G
I
P
R
Y
R
P
D
K
A
E
T
E
P
Q
V
G
T
A
Q
G
L
A
W
T
P
V
G
G
T
L
L
T
I
E
V
A
A
V
P
G
S
G
K
L
S
L
T
G
Q
L
G
E
V
M
K
E
S
A
Q
A
A
L
T
Y
L
R
A
H
T
Q
D
Y
G
L
P
E
D
F
Y
N
K
V
D
L
H
V
H
V
P
D
G
A
T
P
K
D
G
P
S
A
G
I
T
M
A
T
A
I
A
S
A
L
S
R
R
P
A
R
M
D
I
A
M
T
G
E
V
S
L
R
G
K
V
M
P
I
G
G
V
K
E
K
L
L
A
A
H
Q
A
G
I
H
K
I
V
L
P
K
D
N
E
A
Q
L
E
E
L
P
K
E
V
L
E
G
L
E
I
K
L
V
E
D
V
G
E
V
L
E
Y
L
L
L
P
E
-------
26
PsiBlast_CBE
63.77
56%
16
- C4 -
4YPL
2
?
F:
[7-535]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
A
L
R
K
K
I
E
E
V
G
M
P
E
A
V
K
T
K
A
L
K
E
L
D
R
L
E
R
M
Q
Q
G
S
P
E
A
T
V
A
R
T
Y
L
D
W
L
T
E
V
P
W
S
K
A
D
P
E
V
L
D
I
N
H
T
R
Q
V
L
D
E
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
L
T
----
Q
G
L
DVRN
K
A
P
I
L
V
L
V
G
P
P
G
V
G
K
T
S
L
G
R
S
I
A
R
S
M
N
R
K
F
H
R
I
S
L
G
G
V
R
D
E
A
E
I
R
G
H
R
R
T
Y
I
G
A
M
P
G
K
L
I
H
A
M
K
Q
V
G
V
I
N
P
V
I
L
L
D
Q
I
D
K
M
S
S
D
W
R
G
D
P
A
S
A
M
L
E
V
L
D
P
E
Q
N
N
T
F
T
D
H
Y
L
D
V
P
Y
D
L
S
K
V
F
F
I
T
T
A
N
T
L
Q
T
I
P
R
P
L
L
D
R
M
E
V
I
E
I
P
G
Y
T
N
M
E
K
Q
A
I
A
R
Q
Y
L
W
P
K
Q
V
R
E
S
G
M
-
E
G
R
I
E
V
T
D
A
A
I
L
R
V
I
S
E
Y
T
R
E
A
G
V
R
G
L
E
R
E
L
G
K
I
A
R
K
G
A
K
F
W
L
EG
A
W
E
-
G
L
R
--
T
I
D
A
S
D
I
P
T
Y
L
G
I
P
R
Y
R
P
D
K
A
E
T
E
P
Q
V
G
T
A
Q
G
L
A
W
T
P
V
G
G
T
L
L
T
I
E
V
A
A
V
P
G
S
G
K
L
S
L
T
G
Q
L
G
E
V
M
K
E
S
A
Q
A
A
L
T
Y
L
R
A
H
T
Q
D
Y
G
L
P
E
D
F
Y
N
K
V
D
L
H
V
H
V
P
D
G
A
T
P
K
D
G
P
S
A
G
I
T
M
A
T
A
I
A
S
A
L
S
R
R
P
A
R
M
D
I
A
M
T
G
E
V
S
L
R
G
K
V
M
P
I
G
G
V
K
E
K
L
L
A
A
H
Q
A
G
I
H
K
I
V
L
P
K
D
N
E
A
Q
L
E
E
L
P
K
E
V
L
E
G
L
E
I
K
L
V
E
D
V
G
E
V
L
E
Y
L
L
L
P
E
-------
27
PsiBlast_CBE
62.99
56%
16
- C4 -
4YPL
1
?
E:
[7-535]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
A
L
R
K
K
I
E
E
V
G
M
P
E
A
V
K
T
K
A
L
K
E
L
D
R
L
E
R
M
Q
Q
G
S
P
E
A
T
V
A
R
T
Y
L
D
W
L
T
E
V
P
W
S
K
A
D
P
E
V
L
D
I
N
H
T
R
Q
V
L
D
E
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
L
T
----
Q
G
L
DVRN
K
A
P
I
L
V
L
V
G
P
P
G
V
G
K
T
S
L
G
R
S
I
A
R
S
M
N
R
K
F
H
R
I
S
L
G
G
V
R
D
E
A
E
I
R
G
H
R
R
T
Y
I
G
A
M
P
G
K
L
I
H
A
M
K
Q
V
G
V
I
N
P
V
I
L
L
D
Q
I
D
K
M
S
S
D
W
R
G
D
P
A
S
A
M
L
E
V
L
D
P
E
Q
N
N
T
F
T
D
H
Y
L
D
V
P
Y
D
L
S
K
V
F
F
I
T
T
A
N
T
L
Q
T
I
P
R
P
L
L
D
R
M
E
V
I
E
I
P
G
Y
T
N
M
E
K
Q
A
I
A
R
Q
Y
L
W
P
K
Q
V
R
E
S
G
M
-
E
G
R
I
E
V
T
D
A
A
I
L
R
V
I
S
E
Y
T
R
E
A
G
V
R
G
L
E
R
E
L
G
K
I
A
R
K
G
A
K
F
W
L
EG
A
W
E
-
G
L
R
--
T
I
D
A
S
D
I
P
T
Y
L
G
I
P
R
Y
R
P
D
K
A
E
T
E
P
Q
V
G
T
A
Q
G
L
A
W
T
P
V
G
G
T
L
L
T
I
E
V
A
A
V
P
G
S
G
K
L
S
L
T
G
Q
L
G
E
V
M
K
E
S
A
Q
A
A
L
T
Y
L
R
A
H
T
Q
D
Y
G
L
P
E
D
F
Y
N
K
V
D
L
H
V
H
V
P
D
G
A
T
P
K
D
G
P
S
A
G
I
T
M
A
T
A
I
A
S
A
L
S
R
R
P
A
R
M
D
I
A
M
T
G
E
V
S
L
R
G
K
V
M
P
I
G
G
V
K
E
K
L
L
A
A
H
Q
A
G
I
H
K
I
V
L
P
K
D
N
E
A
Q
L
E
E
L
P
K
E
V
L
E
G
L
E
I
K
L
V
E
D
V
G
E
V
L
E
Y
L
L
L
P
E
-------
29
PsiBlast_CBE
62.63
56%
21
- C4 -
4YPL
1
?
C:
[7-535]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
A
L
R
K
K
I
E
E
V
G
M
P
E
A
V
K
T
K
A
L
K
E
L
D
R
L
E
R
M
Q
Q
G
S
P
E
A
T
V
A
R
T
Y
L
D
W
L
T
E
V
P
W
S
K
A
D
P
E
V
L
D
I
N
H
T
R
Q
V
L
D
E
D
H
Y
G
L
K
D
V
K
E
R
I
L
E
Y
L
A
V
R
Q
L
T
----
Q
G
L
DVRN
K
A
P
I
L
V
L
V
G
P
P
G
V
G
K
T
S
L
G
R
S
I
A
R
S
M
N
R
K
F
H
R
I
S
L
G
G
V
R
D
E
A
E
I
R
G
H
R
R
T
Y
I
G
A
M
P
G
K
L
I
H
A
M
K
Q
V
G
V
I
N
P
V
I
L
L
D
Q
I
D
K
M
S
S
D
W
R
G
D
P
A
S
A
M
L
E
V
L
D
P
E
Q
N
N
T
F
T
D
H
Y
L
D
V
P
Y
D
L
S
K
V
F
F
I
T
T
A
N
T
L
Q
T
I
P
R
P
L
L
D
R
M
E
V
I
E
I
P
G
Y
T
N
M
E
K
Q
A
I
A
R
Q
Y
L
W
P
K
Q
V
R
E
S
G
M
-
E
G
R
I
E
V
T
D
A
A
I
L
R
V
I
S
E
Y
T
R
E
A
G
V
R
G
L
E
R
E
L
G
K
I
A
R
K
G
A
K
F
W
L
EG
A
W
E
-
G
L
R
--
T
I
D
A
S
D
I
P
T
Y
L
G
I
P
R
Y
R
P
D
K
A
E
T
E
P
Q
V
G
T
A
Q
G
L
A
W
T
P
V
G
G
T
L
L
T
I
E
V
A
A
V
P
G
S
G
K
L
S
L
T
G
Q
L
G
E
V
M
K
E
S
A
Q
A
A
L
T
Y
L
R
A
H
T
Q
D
Y
G
L
P
E
D
F
Y
N
K
V
D
L
H
V
H
V
P
D
G
A
T
P
K
D
G
P
S
A
G
I
T
M
A
T
A
I
A
S
A
L
S
R
R
P
A
R
M
D
I
A
M
T
G
E
V
S
L
R
G
K
V
M
P
I
G
G
V
K
E
K
L
L
A
A
H
Q
A
G
I
H
K
I
V
L
P
K
D
N
E
A
Q
L
E
E
L
P
K
E
V
L
E
G
L
E
I
K
L
V
E
D
V
G
E
V
L
E
Y
L
L
L
P
E
-------
32
PsiBlast_CBE
47.62
60%
-134
- C4 -
3WU6
1
?
E:
[3-190]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
A
D
N
E
N
R
V
G
Q
V
T
G
L
A
W
T
E
V
G
G
D
L
L
T
I
E
T
A
C
V
P
G
K
G
K
L
T
Y
T
G
S
L
G
E
V
M
Q
E
S
I
Q
A
A
L
T
V
V
R
A
R
A
E
K
L
G
I
N
P
D
F
Y
E
K
R
D
I
H
V
H
V
P
E
G
A
T
P
K
D
G
P
A
A
G
I
A
M
C
T
A
L
V
S
C
L
T
G
N
P
V
R
A
D
V
A
M
T
G
E
I
T
L
R
G
Q
V
L
P
I
G
G
L
K
E
K
L
L
A
A
H
R
G
G
I
K
T
V
L
I
P
F
E
N
K
R
D
L
E
E
I
P
D
N
V
I
A
D
L
D
I
H
P
V
K
R
I
E
E
V
L
T
L
A
L
Q
N
E
-------
33
PsiBlast_CBE
47.55
60%
-136
- C4 -
3WU6
1
?
D:
[10-190]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
G
Q
V
T
G
L
A
W
T
E
V
G
G
D
L
L
T
I
E
T
A
C
V
P
G
K
G
K
L
T
Y
T
G
S
L
G
E
V
M
Q
E
S
I
Q
A
A
L
T
V
V
R
A
R
A
E
K
L
G
I
N
P
D
F
Y
E
K
R
D
I
H
V
H
V
P
E
G
A
T
P
K
D
G
P
A
A
G
I
A
M
C
T
A
L
V
S
C
L
T
G
N
P
V
R
A
D
V
A
M
T
G
E
I
T
L
R
G
Q
V
L
P
I
G
G
L
K
E
K
L
L
A
A
H
R
G
G
I
K
T
V
L
I
P
F
E
N
K
R
D
L
E
E
I
P
D
N
V
I
A
D
L
D
I
H
P
V
K
R
I
E
E
V
L
T
L
A
L
Q
N
E
-------
47
PsiBlast_CBE
47.40
60%
-129
- C4 -
3WU3
1
?
E:
[11-190]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
Q
V
T
G
L
A
W
T
E
V
G
G
D
L
L
T
I
E
T
A
C
V
P
G
K
G
K
L
T
Y
T
G
S
L
G
E
V
M
Q
E
S
I
Q
A
A
L
T
V
V
R
A
R
A
E
K
L
G
I
N
P
D
F
Y
E
K
R
D
I
H
V
H
V
P
E
G
A
T
P
K
D
G
P
A
A
G
I
A
M
C
T
A
L
V
S
C
L
T
G
N
P
V
R
A
D
V
A
M
T
G
E
I
T
L
R
G
Q
V
L
P
I
G
G
L
K
E
K
L
L
A
A
H
R
G
G
I
K
T
V
L
I
P
F
E
N
K
R
D
L
E
E
I
P
D
N
V
I
A
D
L
D
I
H
P
V
K
R
I
E
E
V
L
T
L
A
L
Q
N
E
-------
35
PsiBlast_CBE
47.33
60%
-134
- C4 -
3WU6
1
?
B:
[9-189]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
V
G
Q
V
T
G
L
A
W
T
E
V
G
G
D
L
L
T
I
E
T
A
C
V
P
G
K
G
K
L
T
Y
T
G
S
L
G
E
V
M
Q
E
S
I
Q
A
A
L
T
V
V
R
A
R
A
E
K
L
G
I
N
P
D
F
Y
E
K
R
D
I
H
V
H
V
P
E
G
A
T
P
K
D
G
P
A
A
G
I
A
M
C
T
A
L
V
S
C
L
T
G
N
P
V
R
A
D
V
A
M
T
G
E
I
T
L
R
G
Q
V
L
P
I
G
G
L
K
E
K
L
L
A
A
H
R
G
G
I
K
T
V
L
I
P
F
E
N
K
R
D
L
E
E
I
P
D
N
V
I
A
D
L
D
I
H
P
V
K
R
I
E
E
V
L
T
L
A
L
Q
N
--------