@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28470: (2016-07-15 )
MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMGKSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGIRTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVALAAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEFAKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHPSAV
Atome Classification :
(23 SA)
.........10........20........30........40........50----------------------------.......---------------------------------------------------------.---------------------------------------------------------60.....-----------------------------...70........80........90........100.......110....-.-----..-120.......130.......140.-......150.......160.......170.......180.......190.......200.......210.......220.......230....-...240....-------.----..250------........260......--.270--..----.....280.......290...--.--..-.-300........310.......-------320.-..-----.----..-----..--------.330.......340.......350.......360.......370.--.--.....380.......390.......400......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
G
L
I
V
Q
KFGGTSVG
S
V
E
K
I
Q
N
A
A
N
R
A
I
A
E
KQKG
H
Q
V
V
V
V
V
SAMGK
S
T
D
E
L
V
----------------------------
S
L
A
K
A
IS---------------------------------------------------------D---------------------------------------------------------QPSK
R
E
M
-----------------------------
D
M
L
LATG
E
Q
V
T
I
S
L
L
S
M
A
L
Q
EKGYDAVSYTGWQAG
I
R
T
E
A
IHGN
A
R
I
T
DI-
D
-----
T
S
-
V
L
A
D
Q
LEKG
K
I
V
I
V
AGFQGMTED
C
-
E
I
T
T
LGRGGS
D
T
T
A
V
A
L
A
A
A
LKADK
C
D
I
Y
TDVPGVFTT
D
P
R
Y
V
K
S
A
R
KLEGI
S
Y
D
E
M
L
E
L
A
NLGAGVL
H
P
R
A
V
E
F
A
KNYQ
V
P
L
E
VRSSTETEA-
G
T
L
IEEESSM-------E----Q
N
L
I
-------
V
R
G
IAFED
Q
I
T
R
V
T
I
Y
G--LTS
G
--
L
T
----
T
L
S
T
I
F
T
T
L
A
KRNI
N
V
D
I
I
I
Q
--T--QA-E-D-KTG
I
S
F
S
V
KTEDA
D
Q
T
V
A
V
-------
L
--
E
-
E
Y
-----
K
----
D
A
-----
L
E
--------
F
E
KIETESK
L
A
K
V
S
I
V
GSGMVSNP
G
V
A
A
E
M
F
A
V
L
AQK
N
I
L
I
K
M
VS--T--S
E
I
K
V
S
T
V
VSE
N
D
M
V
K
A
V
E
S
L
H
D
A
F
E
LSKHPSAV
22
PsiBlast_CBE
77.60
44%
-55
- C1 -
3AB2
2
AK_CORGL
E:
[2-408]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
----------------------------
E
L
A
A
A
V
N
---------------------------------------------------------
P
---------------------------------------------------------
V
P
P
A
R
E
M
-----------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
A
G
V
L
T
-----------
V
-
T
-----
P
G
-
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
Q
-------------
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
-
G
T
L
I
--
A
G
S
M
-------
E
DIPV
E
E
A
V
-------
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
G
--
I
S
D
K
--
P
G
----
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
--
S
V
-
E
-
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
A
M
E
I
-------
L
--
K
-
K
L
-----
Q
----
V
Q
-----
G
N
--------
W
T
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
------
1
PsiBlast_PDB
77.22
48%
-53
- C1 -
3L76
5
?
A:
[2-426]
-
A
L
I
V
Q
K
F
G
G
T
S
V
G
T
V
E
R
I
Q
A
V
A
Q
R
I
K
R
T
V
Q
G
G
N
S
L
V
V
V
V
S
A
M
G
K
S
T
D
V
L
V
----------------------------
D
L
A
Q
Q
I
S
---------------------------------------------------------
P
---------------------------------------------------------
N
P
C
R
R
E
M
-----------------------------
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
-------
I
L
E
I
-
R
-----
P
D
-
R
L
E
H
H
L
R
E
G
K
V
V
V
V
A
G
F
Q
G
I
--
H
L
-
E
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
S
S
W
S
D
E
P
-
G
T
K
V
V
A
P
P
V
Q
-------
N
----
R
S
L
V
GLEIAKA
V
D
G
V
E
Y
D
A
D
Q
A
K
V
A
L
L
R
--
V
P
D
R
--
P
G
----
V
A
S
K
L
F
R
D
I
A
Q
Q
Q
V
D
I
D
L
I
I
Q
--
S
--
I
H
-
D
G
N
-
S
N
D
I
A
F
T
V
V
K
D
L
L
N
T
A
E
A
V
T
S
A
I
APA
L
--
R
-
S
Y
-----
P
----
E
A
-----
D
Q
--------
E
A
E
I
I
V
E
K
G
I
A
K
I
A
I
A
G
A
G
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
M
I
S
--
T
--
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
V
T
L
S
P
P
--
77
HHSearch
76.95
51%
-54
- C1 -
3L76
5
?
A:
[2-420]
-
A
L
I
V
Q
K
F
G
G
T
S
V
G
T
V
E
R
I
Q
A
V
A
Q
R
I
K
R
T
V
Q
G
G
N
S
L
V
V
V
V
S
A
M
G
K
S
T
D
V
L
V
----------------------------
D
L
A
Q
Q
I
S
---------------------------------------------------------
P
---------------------------------------------------------
N
P
C
R
R
E
M
-----------------------------
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
-------
I
L
E
I
-
R
-----
P
D
-
R
L
E
H
H
L
R
E
G
K
V
V
V
V
A
G
F
Q
G
I
--
H
L
-
E
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
S
S
W
S
D
E
P
-
G
T
K
V
V
A
P
P
V
Q
NRSLVGL
E
----
I
A
K
A
-------
V
D
G
V
E
Y
D
A
D
Q
A
K
V
A
L
L
R
--
V
P
D
R
--
P
G
----
V
A
S
K
L
F
R
D
I
A
Q
Q
Q
V
D
I
D
L
I
I
Q
--
S
--
I
H
D
G
-
N
-
S
N
D
I
A
F
T
V
V
K
D
L
L
N
T
A
E
A
V
T
S
A
----
I
--
A
-
P
A
-----
L
RSYP
E
A
-----
D
Q
--------
E
A
E
I
I
V
E
K
G
I
A
K
I
A
I
A
G
A
G
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
M
I
S
--
T
--
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
--------
29
PsiBlast_CBE
76.79
44%
-64
- C1 -
3AB4
3
?
E:
[2-409]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
----------------------------
E
L
A
A
A
V
N
---------------------------------------------------------
P
---------------------------------------------------------
V
P
P
A
R
E
M
-----------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
--------------------
T
-----
P
G
-
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
------------
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
-
G
T
L
I
--
A
G
S
M
-------
E
DIPV
E
E
A
V
-------
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
G
--
I
S
D
K
--
P
G
----
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
--
N
---------
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
A
M
E
I
-------
L
--
K
-
K
L
-----------
Q
-----
G
N
--------
W
T
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-----
21
PsiBlast_CBE
76.57
44%
-49
- C1 -
3AB2
5
AK_CORGL
O:
[2-411]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
----------------------------
E
L
A
A
A
V
N
---------------------------------------------------------
P
---------------------------------------------------------
V
P
P
A
R
E
M
-----------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
A
G
V
L
T
-------------
T
-----
P
G
-
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
Q
------------
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
-
G
T
L
I
--
A
G
S
M
-------
E
DIPV
E
E
A
V
-------
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
G
--
I
S
D
K
--
P
G
----
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
NV
S
--
S
V
-
E
-
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
A
M
E
I
-------
L
--
K
-
K
L
-----
Q
----
V
Q
-----
G
N
--------
W
T
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
E
D
---
23
PsiBlast_CBE
75.90
44%
-9
- C1 -
3AAW
4
AK_CORGL
C:
[1-409]
M
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
----------------------------
E
L
A
A
A
V
N
---------------------------------------------------------
P
---------------------------------------------------------
V
P
P
A
R
E
M
-----------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
---------------
D
V
-
T
-----
P
G
-
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
Q
G
V
N
K
--R
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
-
G
T
L
I
--
A
G
S
M
-------
E
DIPV
E
E
A
V
-------
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
G
--
I
S
D
K
--
P
G
----
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
--
S
V
-
E
-
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
A
M
E
I
-------
L
--
K
-
K
L
-----
Q
----
V
Q
-----
G
N
--------
W
T
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-----
24
PsiBlast_CBE
75.46
44%
-54
- C1 -
3AB4
13
?
O:
[2-407]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
----------------------------
E
L
A
A
A
V
N
---------------------------------------------------------
P
---------------------------------------------------------
V
P
P
A
R
E
M
-----------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
------------------
D
V
-
T
-----
P
G
-
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
----------------
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
-
G
T
L
I
--
A
G
S
M
-------
E
DIPV
E
E
A
V
-------
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
G
--
I
S
D
K
--
P
G
----
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
--
N
-------
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
A
M
E
I
-------
L
--
K
-
K
------------
Q
-----
G
N
--------
W
T
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
-------
30
PsiBlast_CBE
74.90
44%
-43
- C1 -
3AB4
3
?
C:
[2-409]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
----------------------------
E
L
A
A
A
V
N
---------------------------------------------------------
P
---------------------------------------------------------
V
P
P
A
R
E
M
-----------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
---------------------
T
-----
P
G
-
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
-----------------
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
-
G
T
L
I
--
A
G
S
M
-------
E
DIPV
E
E
A
V
-------
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
G
--
I
S
D
K
--
P
G
----
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
--
N
V------
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
A
M
E
I
-------
L
--
K
-
K
L
-----
Q
----
V
Q
-----
G
N
--------
W
T
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-----
2
PsiBlast_PDB
73.27
44%
-11
- C1 -
3AAW
3
AK_CORGL
A:
[2-409]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
----------------------------
E
L
A
A
A
V
N
---------------------------------------------------------
P
---------------------------------------------------------
V
P
P
A
R
E
M
-----------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
-------------------
V
-
T
-----
P
G
-
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
G
F
--
V
N
K
E
T
R
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
-
G
T
L
I
--
A
G
S
M
-------
E
DIPV
E
E
A
V
-------
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
G
--
I
S
D
K
--
P
G
----
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
--
S
V
-
E
-
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
A
M
E
I
-------
L
--
K
-
K
L
-----
Q
----
V
Q
-----
G
N
--------
W
T
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-----
28
PsiBlast_CBE
72.54
44%
-52
- C1 -
3AB4
1
?
G:
[2-407]
-
A
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
----------------------------
E
L
A
A
A
V
N
---------------------------------------------------------
P
---------------------------------------------------------
V
P
P
A
R
E
M
-----------------------------
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
------------------------------
R
V
R
E
A
L
D
E
G
K
I
C
I
V
A
-----------------
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
N
D
P
-
G
T
L
I
--
A
G
S
M
-------
E
DIPV--
A
V
-------
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
L
G
--
I
S
D
K
--
P
G
----
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
--
N
VF-------
T
T
D
I
T
F
T
C
P
R
S
D
G
R
R
A
M
E
I
-------
L
--
K
-
K
L
-----
Q
----
V
Q
---------------
W
T
N
V
L
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
-------
32
PsiBlast_CBE
68.58
32%
-4
- C1 -
3C1N
2
AK_METJA
D:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
---
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
D
VRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
----------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GELT
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
----------------
D
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
GVSG
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-----
G
----
D
--------LNNNL---
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
74
HHSearch
68.53
36%
0
- C1 -
3C1M
6
AK_METJA
A:
[2-470]
--
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
----------------------------
E
I
S
Q
Q
A
L
DVRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
KS
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
G
---------------------------------------------------------
E
L
T
P
K
S
R
-----------------------------
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
V----
K
E
-
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
E
--------
M
----
S
D
S
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
--
A
G
M
V
G
V
S
G
----
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
--
G
--
S
S
-
E
----
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
-
R
E
-----
F
----
G
D
SFLNN
N
L
--------
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
------
33
PsiBlast_CBE
68.41
32%
-23
- C1 -
3C1N
3
AK_METJA
B:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
D
VRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
K
---------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GELT
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
----------
S
----
D
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
GVSG
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-----
G
----
D
--------LNNNL---
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
3
PsiBlast_PDB
68.24
32%
-23
* C1 *
3C1N
2
AK_METJA
C:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
D
VRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
K
---------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GELT
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
---------------
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
GVSG
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-------------------LNNNL---
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
35
PsiBlast_CBE
67.71
32%
-9
- C1 -
3C1M
4
AK_METJA
C:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
EISQQALDVRDIAKVGDFIKFIREKHYK
A
I
E
E
A
I
K
---------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
KKIIDSRIEELEKVLIGVAYLGELTPKSR
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
E
M
-------
S
----
D
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
GVSG
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-----
G
----
D
------
G
K
KSFLNNNL
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
36
PsiBlast_CBE
67.43
32%
-11
- C1 -
3C1M
2
AK_METJA
B:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
EISQQALDVRDIAKVGDFIKFIREKHYK
A
I
E
E
A
I
K
---------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
KKIIDSRIEELEKVLIGVAYLGELTPKSR
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
E
M
-------
S
----
D
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
GVSG
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-----
G
----
D
--------SFLNNNL-
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
93
Fugue
67.18
36%
4
- C1 -
3C1M
6
AK_METJA
A:
[2-470]
--
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
----------------------------
E
I
S
Q
Q
A
L
---------------------------------------------------------
D
VRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
KS
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
G
E
L
T
P
K
S
R
-----------------------------
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
E
V
-----
K
E
-
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
E
M
-------
S
----
D
S
I
V
--------
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
AG
M
V
G
V
--
S
G
----
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
--
V
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
-
R
E
FGDSF
L
----
N
N
-----
N
L
--------
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
--
Q
GS
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
------
5
PsiBlast_PDB
66.57
32%
-12
- C1 -
3C1M
6
AK_METJA
A:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
DVRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
K
---------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GELT
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
E
M
-------
S
----
D
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-----
G
----
D
--------SFLNNNL-
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
34
PsiBlast_CBE
66.52
32%
-8
- C1 -
3C1M
4
AK_METJA
D:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
EISQQALDVRDIAKVGDFIKFIREKHYK
A
I
E
E
A
I
K
---------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
KKIIDSRIEELEKVLIGVAYLGELTPKSR
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
E
M
-------
S
----
D
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
GVSG
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-----
G
----
D
--------KSFLNNNL
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
37
PsiBlast_CBE
66.26
32%
-10
- C1 -
2HMF
2
AK_METJA
D:
[3-466]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
EISQQALDVRDIAKVGDFIKFIREKHYK
A
I
E
E
A
I
K
---------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
KKIIDSRIEELEKVLIGVAYLGELTPKSR
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
E
M
-------
S
----
D
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
GVSG
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-----
G
----
D
F
-------LNNNL---
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
4
PsiBlast_PDB
65.00
32%
-7
- C1 -
3C20
3
AK_METJA
A:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
Q
Q
A
L
D
VRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
K
---------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GELT
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
E
M
-------
S
----
D
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
GVSG
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-----
G
----
D
--------SFLNNNL-
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
31
PsiBlast_CBE
64.73
32%
-10
- C1 -
3C20
3
AK_METJA
B:
[4-467]
----
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
EISQQALDVRDIAKVGDFIKFIREKHYK
A
I
E
E
A
I
K
---------------------------------------------------------
S
---------------------------------------------------------
E
E
I
K
E
E
V
KKIIDSRIEELEKVLIGVAYLGELTPKSR
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
-
E
-----
V
K
E
R
L
L
P
L
L
K
E
G
I
I
P
V
V
T
G
F
I
G
T
T
E
E
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
S
E
G
T
L
I
T
N
D
M
E
M
-------
S
----
D
S
-
I
-------
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
----
A
G
--
M
V
GVSG
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
--
I
L
I
--
S
--
Q
G
-
S
-
S
-
E
T
N
I
S
L
V
V
S
E
E
D
V
D
K
A
L
K
A
-------
L
--
K
R
E
F
-----
G
----
D
--------KSFLNNNL
I
R
D
V
S
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
---------
73
HHSearch
62.08
32%
-14
- C1 -
2J0W
4
AK3_ECOLI
A:
[3-448]
-
E
I
V
V
S
K
F
G
G
T
S
V
A
D
F
D
A
M
N
R
S
A
D
I
V
L
S
D
---
A
N
V
R
L
V
V
L
S
A
S
A
G
I
T
N
L
L
V
----------------------------
A
L
A
E
G
L
E
---------------------------------------------------------
P
G
E
R
F
E
K
L
D
A
I
R
N
I
Q
F
A
I
L
E
R
LRYP
N
V
I
R
E
E
I
E
R
L
L
E
N
I
T
V
L
A
E
A
A
A
L
----------
A
T
S
P
A
L
T
-----------------------------
D
E
L
V
S
H
G
E
L
M
S
T
L
L
F
V
E
I
L
R
E
R
D
V
Q
A
Q
W
F
D
V
R
K
V
-
M
R
T
N
D
R
F
G
R
A
E
P
D
I
A
-
A
L
A
E
L
A
A
L
-
Q
L
L
P
R
L
N
E
-
G
L
V
I
T
Q
G
F
I
G
S
E
N
K
G
-
R
T
T
T
L
G
R
G
G
S
D
Y
T
A
A
L
L
A
E
A
L
H
A
S
R
V
D
I
W
T
D
V
P
G
I
Y
T
T
D
P
R
V
V
S
A
A
K
R
I
D
E
I
A
F
A
E
A
A
E
M
A
T
F
G
A
K
V
L
H
P
A
T
L
L
P
A
V
R
S
D
I
P
V
F
V
G
S
S
K
D
P
R
A
G
G
T
L
V
C
N
K
T
---------
E
----
N
P
P
L
-------
F
R
A
L
A
L
R
R
N
Q
T
L
L
T
L
H
S
--
L
N
M
L
HS
R
G
----
F
L
A
E
V
F
G
I
L
A
R
H
N
I
S
V
D
L
I
T
T
--
S
--
E
V
-------
S
V
A
L
T
L
D
T
T
G
S
T
S
T
G
D
T
-------
L
LT
Q
-
S
L
-----
L
----
M
E
-----
L
S
A
-------
L
C
R
V
E
V
E
E
G
L
A
L
V
A
L
I
G
N
D
L
S
K
A
C
G
V
G
K
E
V
F
G
V
L
E
P
F
N
I
R
M
I
C
Y
G
--
A
--
S
S
H
N
L
C
F
L
V
P
G
E
D
A
E
Q
V
V
Q
K
L
H
S
N
L
F
--------