@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28560: (2016-07-15 )
MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAISFYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVVQTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPKNILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTTGAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGFEMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAALPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSEETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIADRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKADTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK
Atome Classification :
(20 SA)
.........10........20....-....30........40..-..----.---------.-----..50........60......-..70........80........90........100-.......110.......120.......130.--.....-.140.--.......150.......160.......170...--....180.......190-.---.------.......200.-......210.......220.......230...-....-240-.--....------..250...--....260.......270.......280--..--..----..--..--290...--...----.300.......310..-----.....320.......330.......340.-.-.....-350----.........-360-----------.....--------...370...----...------...380.......390.......400.......-----410.......420......-.-430----------------.........440.......450.......460.......470....-...480.........490......-----------------.500...---.-----...510.......520...-....530..-------.....540.......550....----...560
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQSQK
P
W
L
A
EYPNDIPHELPL
P
N
K
T
-
L
Q
S
I
L
T
D
S
A
ARFPDK
T
A
I
-
S
F----Y---------G-----KKL
T
F
H
D
I
L
T
D
A
L
K
L
A
A
F
L
Q-CNGLQKG
D
R
V
A
V
MLPNC
P
Q
T
V
I
S
Y
Y
G
V
L
FAG
G
I
V
V
-QTNPLYTEH
E
L
E
Y
Q
LRD
A
Q
V
S
V
I
I
T
L
DLLFP--KAI
K
M
-
K
T
L
-
S
--
I
V
D
Q
I
L
I
T
S
V
K
D
YLPF
P
K
N
ILYPLTQ
K
Q
K
V
H
I
D--FDKTA
N
I
H
T
F
A
S
C
M
K
---Q---E------KT
E
L
L
TIPKID-PEH
D
I
A
V
L
Q
YTGGTTGAPK
G
V
M
L
T
H
Q
N
ILA
N
T
-
E
M
C
A
-
A
W
M
-
Y
--
D
V
K
E
------
G
A
E
K
V
L
G
I
--
V
P
F
F
H
V
Y
G
L
T
A
V
M
N
Y
S
I
K
L
G
F
E
M
I
L
L---PK--FD----P
L
--
E
T
--
L
K
I
I
DK--HKP----TLFPGA
P
T
I
Y
I
G
LLHH-----PELQHY
D
L
S
S
I
K
S
C
LSGSAAL
P
V
E
V
K
Q
K
F
-
E
-KVTG
G
-
K
------
L
V
E
GYGLSE-AS------------PV
T
H
A
--------
N
F
I
W--GKN----KPG------SIGCPWPSTD
A
A
I
YSEETGELAAPYEH
G
E
I
I
V
K-----GP
Q
V
M
K
GYWN
K
P
E
E
T
A
A
V
L
-R-D------------------
G
W
L
F
TGDMGYMDEE
G
F
F
Y
I
ADRKK
D
I
I
I
AGGYNI
Y
P
R
E
V
E
E
A
L
Y
E
H
-
E
A
I
Q
--
E
I
V
VAGVPDSYRG
E
T
V
K
A
-----------------
F
V
V
L
KKG---A-----KA
D
T
E
E
L
D
A
F
A
R
SRLAPYK-V
P
K
A
Y
E
F
R
K
-------EL
P
K
T
A
V
G
K
I
L
R
R
R
L
L
E
E
ETEN----HHIK
37
PsiBlast_PDB
83.91
29%
-26
- C3 -
3NI2
4
?
A:
[18-532]
--------------
I
P
K
N
L
P
L
H
S
Y
V
-
L
E
N
L
S
N
H
S
S
K
P
C
L
I
N
G
A
--------
N
---------
G
-----
D
V
Y
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
-
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
Q
A
C
Y
Y
E
--
K
V
K
D
F
-
A
R
E
-
S
--
D
V
K
V
M
C
V
D
S
A
P
D
---------------------------
G
C
L
H
-
F
S
E
L
T
Q
---
A
---
D
------
E
N
E
---
A
P
Q
V
D
I
S
P
D
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
L
I
T
S
V
------
A
Q
Q
-
V
--
D
G
D
N
PN
L
Y
F
H
S
E
D
V
I
L
C
V
--
L
P
M
F
H
I
Y
A
L
N
S
I
M
L
C
G
L
R
V
G
A
P
I
L
I
M
---
P
K
--
F
E
----
I
G
--
S
L
--
L
G
L
I
E
K
--
Y
K
V
----
S
I
A
P
V
V
P
P
V
M
M
S
I
A
K
S
-----
P
D
L
D
K
H
D
L
S
S
L
R
M
I
K
S
G
G
A
P
L
G
K
E
L
E
D
T
V
-
R
A
K
F
P
Q
A
-
R
------
L
G
Q
G
Y
G
M
T
E
-
A
G
------------
P
V
L
A
M
--------
C
L
A
F
--
A
K
E
P
F
D
I
K
P
G
------
A
C
G
T
V
V
R
N
A
E
M
K
I
V
D
P
E
T
G
A
S
L
P
R
N
Q
P
G
E
I
C
I
R
-----
G
D
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
D
K
-
E
------------------
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
-
P
E
I
S
--
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
-----------------
F
V
V
K
S
E
K
---
S
-----
Q
A
T
E
D
E
I
K
Q
Y
I
S
K
Q
V
I
F
Y
K
-
R
I
K
R
V
F
F
I
E
-------
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
------------
36
PsiBlast_PDB
82.96
29%
-26
- C3 -
3A9V
1
?
A:
[18-532]
--------------
I
P
K
N
L
P
L
H
S
Y
V
-
L
E
N
L
S
N
H
S
S
K
P
C
L
I
N
G
A
--------
N
---------
G
-----
D
V
Y
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
-
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
Q
A
C
Y
Y
E
--
K
V
K
D
F
-
A
R
E
-
S
--
D
V
K
V
M
C
V
D
S
A
P
D
---------------------------
G
C
L
H
-
F
S
E
L
T
Q
---
A
---
D
------
E
N
E
---
A
P
Q
V
D
I
S
P
D
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
L
I
T
S
V
------
A
Q
Q
-
V
--
D
G
D
N
PN
L
Y
F
H
S
E
D
V
I
L
C
V
--
L
P
M
F
H
I
Y
A
L
N
S
I
M
L
C
G
L
R
V
G
A
P
I
L
I
M
---
P
K
--
F
E
----
I
G
--
S
L
--
L
G
L
I
E
K
--
Y
K
V
----
S
I
A
P
V
V
P
P
V
M
M
S
I
A
K
S
-----
P
D
L
D
K
H
D
L
S
S
L
R
M
I
K
S
G
G
A
P
L
G
K
E
L
E
D
T
V
-
R
A
K
F
P
Q
A
-
R
------
L
G
Q
G
Y
G
M
T
E
-
A
G
------------
P
V
L
A
M
--------
C
L
A
F
--
A
K
E
P
F
D
I
K
P
G
------
A
C
G
T
V
V
R
N
A
E
M
K
I
V
D
P
E
T
G
A
S
L
P
R
N
Q
P
G
E
I
C
I
R
-----
G
D
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
D
K
-
E
------------------
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
-
P
E
I
S
--
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
-----------------
F
V
V
K
S
E
K
---
S
-----
Q
A
T
E
D
E
I
K
Q
Y
I
S
K
Q
V
I
F
Y
K
-
R
I
K
R
V
F
F
I
E
-------
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
------------
39
PsiBlast_PDB
82.52
30%
-35
- C3 -
5BUS
3
MENE_BACSU
A:
[11-479]
------------------------------
L
M
Q
R
A
Q
L
T
P
E
R
I
A
L
-
I
Y
----
E
---------
D
-----
Q
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
-
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
-
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
-
D
S
S
F
E
--
K
----------------------
K
E
Y
----
E
H
I
V
------
Q
T
I
D
V
D
E
L
M
K
E
A
A
E
E
I
E
I
E
A
Y
M
Q
---
M
---
D
------
A
T
---------------
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
Y
F
S
A
--
V
S
S
-
A
L
N
-
L
--
G
I
T
E
-------
Q
D
R
W
L
I
A
--
L
P
L
F
H
I
S
G
L
S
A
L
F
K
-
S
V
I
Y
G
M
T
V
V
L
H
---
Q
R
--
F
S
----
V
S
--
D
V
--
L
H
S
I
N
R
--
H
E
V
----
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
--------
E
E
T
N
R
C
P
E
S
I
R
C
I
L
L
G
G
G
P
A
P
L
P
L
L
E
E
C
-
R
-
E
-
K
G
F
-
P
------
V
F
Q
S
Y
G
M
T
E
T
C
S
------------
Q
I
V
T
L
--------
S
P
E
F
--
S
M
E
----
K
L
G
------
S
A
G
K
P
L
F
S
C
E
I
K
I
--
E
R
D
G
Q
V
C
E
P
Y
E
H
G
E
I
M
V
K
-----
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
-
N
------------------
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
-
P
A
V
A
--
E
A
G
V
S
G
A
E
D
K
K
--
K
V
P
H
A
-----------------
Y
L
V
L
H
K
P
---
V
-----
S
A
G
--
E
L
T
D
Y
C
K
E
R
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
-------
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
---------------
42
PsiBlast_PDB
82.28
31%
4
* C3 *
2D1Q
1
LUCI_LUCCR
A:
[19-539]
-------------------
P
I
E
E
G
S
-
A
G
T
Q
L
R
K
Y
M
E
R
Y
A
K
L
G
A
I
-
A
F
----
T
NAVT-----
G
-----
V
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
-
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
K
K
G
L
D
--
K
V
I
T
V
Q
K
T
V
-
T
--
T
I
K
T
I
V
I
L
D
S
K
--------------------
V
D
--
Y
R
G
Y
Q
C
L
D
T
F
I
K
R
N
T
---
P
PGF
Q
------
A
S
S
F
K
T
V
-
E
V
D
-
R
K
E
Q
V
A
L
I
M
N
S
S
----
L
P
K
G
V
Q
L
T
H
E
N
I
V
T
R
F
-
S
H
A
R
-
D
P
I
-
Y
GN
Q
V
S
P
------
G
T
-
A
V
L
T
V
--
V
P
F
H
H
G
F
G
M
F
T
T
L
G
Y
L
I
-
C
G
F
R
V
V
M
L
---
T
K
--
F
D
----
E
E
--
T
F
--
L
K
T
L
Q
D
--
Y
K
C
----
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
-----
E
L
L
N
K
Y
D
L
S
N
L
V
E
I
A
S
G
G
A
P
L
S
K
E
V
G
E
A
V
A
R
-
R
F
N
L
P
-
G
------
V
R
Q
G
Y
G
L
T
E
-
T
---------------
T
S
A
--------
I
I
I
T
PE
G
D
D
----
K
P
G
------
A
S
G
K
V
V
P
L
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
K
E
L
I
D
E
-
E
------------------
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
-
P
S
I
F
--
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
-----------------
V
V
V
L
E
S
G
---
K
-----
N
M
T
E
K
E
V
M
D
Y
V
A
S
Q
V
S
N
A
K
R
L
R
G
G
V
R
F
V
D
-------
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
-------------
10
HHSearch
81.82
28%
-33
- C3 -
4WV3
1
?
A:
[10-518]
-----------------------
Y
N
-
A
V
D
I
L
E
R
N
L
P
V
R
A
N
K
T
A
L
-
F
T
----
P
---------
D
-----
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
-
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
-
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
E
F
L
P
--
L
I
E
S
I
-
R
G
N
L
P
--
M
L
E
H
I
V
V
I
G
-------------------------------
G
Y
L
S
F
N
D
W
I
R
---
P
---
Q
------
P
T
T
L
-
E
-
A
A
Q
S
-
H
R
E
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
T
A
-
Q
L
W
G
V
N
V
L
-
G
----
L
R
------
E
S
D
R
T
F
A
L
--
A
K
L
F
F
T
F
G
T
G
G
N
L
I
F
P
W
Y
V
G
A
S
C
V
L
F
---
P
G
AA
R
V
----
A
S
--
N
V
--
L
S
T
I
S
R
--
F
K
P
----
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
-----
K
D
F
S
Q
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
A
W
-
K
-
E
A
T
G
V
-
D
------
I
I
D
G
I
G
C
T
E
-
N
F
------------
H
I
F
I
S
--------
N
R
P
---
G
D
I
----
R
P
G
------
S
S
G
K
P
V
E
G
Y
E
L
K
L
V
D
D
E
-
G
K
T
V
P
A
G
E
I
G
N
V
L
L
R
-----
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
-
Q
-
G
------------------
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
-
P
A
V
Q
--
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
-----------------
F
I
I
L
K
P
E
---
Q
I
P
S
--
E
A
L
I
R
Q
I
T
D
H
C
T
E
K
M
A
A
Y
K
-
R
P
R
W
I
E
F
V
T
-------
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
L
---------
43
PsiBlast_PDB
81.52
31%
4
- C3 -
2D1R
2
LUCI_LUCCR
A:
[19-539]
-------------------
P
I
E
E
G
S
-
A
G
T
Q
L
R
K
Y
M
E
R
Y
A
K
L
G
A
I
-
A
F
----
T
NAVT-----
G
-----
V
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
-
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
K
K
G
L
D
--
K
V
I
T
V
Q
K
T
V
-
T
--
T
I
K
T
I
V
I
L
D
S
K
--------------------
V
D
--
Y
R
G
Y
Q
C
L
D
T
F
I
K
R
N
T
---
P
PGF
Q
------
A
S
S
F
K
T
V
-
E
V
D
-
R
K
E
Q
V
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
E
N
I
V
T
R
F
-
S
H
A
R
-
D
P
I
-
Y
GN
Q
V
S
P
------
G
T
-
A
V
L
T
V
--
V
P
F
H
H
G
F
G
M
F
T
T
L
G
Y
L
I
-
C
G
F
R
V
V
M
L
---
T
K
--
F
D
----
E
E
--
T
F
--
L
K
T
L
Q
D
--
Y
K
C
----
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
-----
E
L
L
N
K
Y
D
L
S
N
L
V
E
I
A
S
G
G
A
P
L
S
K
E
V
G
E
A
V
A
R
-
R
F
N
L
P
-
G
------
V
R
Q
G
Y
G
L
T
E
-
T
---------------
T
S
A
--------
I
I
I
T
PE
G
D
D
----
K
P
G
------
A
S
G
K
V
V
P
L
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
K
E
L
I
D
E
-
E
------------------
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
-
P
S
I
F
--
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
-----------------
V
V
V
L
E
S
G
---
K
-----
N
M
T
E
K
E
V
M
D
Y
V
A
S
Q
V
S
N
A
K
R
L
R
G
G
V
R
F
V
D
-------
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
-------------
41
PsiBlast_PDB
81.25
31%
0
- C3 -
2D1T
3
LUCI_LUCCR
A:
[19-539]
-------------------
P
I
E
E
G
S
-
A
G
T
Q
L
R
K
Y
M
E
R
Y
A
K
L
G
A
I
-
A
F
----
T
NAVT-----
G
-----
V
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
-
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
K
K
G
L
D
--
K
V
I
T
V
Q
K
T
V
-
T
--
T
I
K
T
I
V
I
L
D
S
K
--------------------
V
D
--
Y
R
G
Y
Q
C
L
D
T
F
I
K
R
N
T
PPG
Y
---
Q
------
A
S
S
F
K
T
V
-
E
V
D
-
R
K
E
Q
V
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
E
N
I
V
T
R
F
-
S
H
A
R
-
D
P
I
-
Y
GN
Q
V
S
P
------
G
T
-
A
V
L
T
V
--
V
P
F
H
H
G
F
G
M
F
T
T
L
G
Y
L
I
-
C
G
F
R
V
V
M
L
---
T
K
--
F
D
----
E
E
--
T
F
--
L
K
T
L
Q
D
--
Y
K
C
----
T
N
V
I
L
V
P
T
L
F
A
I
L
N
K
S
-----
E
L
L
N
K
Y
D
L
S
N
L
V
E
I
A
S
G
G
A
P
L
S
K
E
V
G
E
A
V
A
R
-
R
F
N
L
P
-
G
------
V
R
Q
G
Y
G
L
T
E
-
T
---------------
T
S
A
--------
I
I
I
T
PE
G
D
D
----
K
P
G
------
A
S
G
K
V
V
P
L
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
K
E
L
I
D
E
-
E
------------------
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
-
P
S
I
F
--
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
-----------------
V
V
V
L
E
S
G
---
K
-----
N
M
T
E
K
E
V
M
D
Y
V
A
S
Q
V
S
N
A
K
R
L
R
G
G
V
R
F
V
D
-------
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
-------------
40
PsiBlast_PDB
81.14
31%
5
- C3 -
2D1S
3
LUCI_LUCCR
A:
[19-539]
-------------------
P
I
E
E
G
S
-
A
G
T
Q
L
R
K
Y
M
E
R
Y
A
K
L
G
A
I
-
A
F
----
T
NAVT-----
G
-----
V
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
-
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
K
K
G
L
D
--
K
V
I
T
V
Q
K
T
V
-
T
--
T
I
K
T
I
V
I
L
D
S
K
--------------------
V
D
--
Y
R
G
Y
Q
C
L
D
T
F
I
K
R
N
T
---
P
PGF
Q
------
A
S
S
F
K
T
V
-
E
V
D
-
R
K
E
Q
V
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
E
N
I
V
T
R
F
-
S
H
A
R
-
D
P
I
-
Y
GN
Q
V
S
P
------
G
T
-
A
V
L
T
V
--
V
P
F
H
H
G
F
G
M
F
T
T
L
G
Y
L
I
-
C
G
F
R
V
V
M
L
---
T
K
--
F
D
----
E
E
--
T
F
--
L
K
T
L
Q
D
--
Y
K
C
----
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
-----
E
L
L
N
K
Y
D
L
S
N
L
V
E
I
A
S
G
G
A
P
L
S
K
E
V
G
E
A
V
A
R
-
R
F
N
L
P
-
G
------
V
R
Q
G
Y
G
L
T
E
-
T
---------------
T
S
A
--------
I
I
I
T
PE
G
D
D
----
K
P
G
------
A
S
G
K
V
V
P
L
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
K
E
L
I
D
E
-
E
------------------
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
-
P
S
I
F
--
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
-----------------
V
V
V
L
E
S
G
---
K
-----
N
M
T
E
K
E
V
M
D
Y
V
A
S
Q
V
S
N
A
K
R
L
R
G
G
V
R
F
V
D
-------
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
-------------
35
PsiBlast_PDB
80.63
29%
-31
- C3 -
3A9U
-
?
A:
[18-532]
--------------
I
P
K
N
L
P
L
H
S
Y
V
-
L
E
N
L
S
N
H
S
S
K
P
C
L
I
N
G
A
--------
N
---------
G
-----
D
V
Y
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
-
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
Q
A
C
Y
Y
E
--
K
V
K
D
F
-
A
R
E
----
D
V
K
V
M
C
V
D
S
A
P
D
---------------------------
G
C
L
H
-
F
S
E
L
T
Q
---
A
---
D
------
E
N
E
---
A
P
Q
V
D
I
S
P
D
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
L
I
T
S
V
------
A
Q
Q
-
V
--
D
G
D
N
PNLYFH
S
E
D
V
I
L
C
V
--
L
P
M
F
H
I
Y
A
L
N
S
I
M
L
C
G
L
R
V
G
A
P
I
L
I
M
---
P
K
--
F
E
----
I
G
--
S
L
--
L
G
L
I
E
K
--
Y
K
V
----
S
I
A
P
V
V
P
P
V
M
M
S
I
A
K
S
-----
P
D
L
D
K
H
D
L
S
S
L
R
M
I
K
S
-------
E
L
E
D
T
V
-
R
A
K
F
P
Q
A
-
R
------
L
G
Q
G
Y
G
M
T
E
-
A
G
------------
P
V
L
A
M
--------
C
L
A
F
--
A
K
E
P
F
D
I
K
P
G
------
A
C
G
T
V
V
R
N
A
E
M
K
I
V
D
P
E
T
G
A
S
L
P
R
N
Q
P
G
E
I
C
I
R
-----
G
D
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
D
K
-
E
------------------
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
-
P
E
I
S
--
D
A
A
V
V
G
L
K
D
E
D
A
G
E
V
P
V
A
-----------------
F
V
V
K
S
E
K
---
S
-----
Q
A
T
E
D
E
I
K
Q
Y
I
S
K
Q
V
I
F
Y
K
-
R
I
K
R
V
F
F
I
E
-------
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
------------
38
PsiBlast_PDB
80.33
30%
-35
- C3 -
5BUR
9
MENE_BACSU
A:
[11-479]
------------------------------
L
M
Q
R
A
Q
L
T
P
E
R
I
A
L
-
I
Y
----
E
---------
D
-----
Q
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
-
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
-
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
-
D
S
S
F
E
--
K
----------------------
K
E
Y
----
E
H
I
V
------
Q
T
I
D
V
D
E
L
M
K
E
A
A
E
E
I
E
I
E
A
Y
M
Q
---
M
---
D
------
A
T
---------------
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
Y
F
S
A
--
V
S
S
-
A
L
N
-
L
--
G
I
T
E
-------
Q
D
R
W
L
I
A
--
L
P
L
F
H
I
S
G
L
S
A
L
F
K
-
S
V
I
Y
G
M
T
V
V
L
H
---
Q
R
--
F
S
----
V
S
--
D
V
--
L
H
S
I
N
R
--
H
E
V
----
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
--------
E
E
T
N
R
C
P
E
S
I
R
C
I
L
L
G
G
G
P
A
P
L
P
L
L
E
E
C
-
R
-
E
-
K
G
F
-
P
------
V
F
Q
S
Y
G
M
T
E
T
C
S
------------
Q
I
V
T
L
--------
S
P
E
F
--
S
M
E
----
K
L
G
------
S
A
G
K
P
L
F
S
C
E
I
K
I
--
E
R
D
G
Q
V
C
E
P
Y
E
H
G
E
I
M
V
K
-----
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
-
N
------------------
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
-
P
A
V
A
--
E
A
G
V
S
G
A
E
D
K
--
G
K
V
P
H
A
-----------------
Y
L
V
L
H
K
P
---
V
-----
S
A
G
--
E
L
T
D
Y
C
K
E
R
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
-------
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
---------------
7
HHSearch
80.29
31%
3
- C3 -
2D1S
3
LUCI_LUCCR
A:
[18-543]
------------------
Y
P
I
E
E
G
S
-
A
G
T
Q
L
R
K
Y
M
E
R
Y
A
K
L
G
A
I
-
A
F
TNAV
T
---------
G
-----
V
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
-
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
K
K
G
L
D
--
K
V
I
T
V
-
Q
K
T
V
T
--
T
I
K
T
I
V
I
L
D
S
K
V
--
D
Y
-----------------------
R
G
Y
Q
C
L
D
T
F
I
K
---
R
---
N
TPPGFQ
A
S
S
F
K
T
-
V
E
V
D
-
R
K
E
Q
V
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
E
N
I
V
T
R
F
-
S
H
A
R
-
D
P
I
Y
G
--
N
Q
V
S
------
P
G
T
A
V
L
T
V
--
V
P
F
H
H
G
F
G
M
F
-
T
T
L
G
Y
L
I
C
G
F
R
V
V
M
L
---
T
K
--
F
D
----
E
E
--
T
F
--
L
K
T
L
Q
D
--
Y
K
C
----
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
-----
E
L
L
N
K
Y
D
L
S
N
L
V
E
I
A
S
G
G
A
P
L
S
K
E
V
G
E
A
V
-
A
-
R
R
F
N
L
P
G
------
V
R
Q
G
Y
G
L
T
E
-
T
T
------------
S
A
I
I
I
--------
T
P
E
---
G
D
D
----
K
P
G
------
A
S
G
K
V
V
P
L
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
K
E
L
I
-
D
E
E
------------------
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
-
P
S
I
F
--
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
-----------------
V
V
V
L
E
S
G
---
K
-----
N
M
T
E
K
E
V
M
D
Y
V
A
S
Q
V
S
N
A
K
R
L
R
G
G
V
R
F
V
D
-------
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
I
L
K
K
---------
45
PsiBlast_PDB
78.41
27%
-56
- C3 -
4WV3
1
?
A:
[25-512]
---------------------------------------
N
K
T
A
L
-
F
T
----
P
---------
D
-----
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
-
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
-
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
E
F
L
P
--------------------
L
I
E
S
I
R
G
N
L
P
M
L
E
H
I
V
V
I
G
-----
G
Y
L
S
--
F
N
D
W
I
R
P
Q
P
T
T
L
E
A
A
---
Q
---
S
------
H
R
E
------------
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
T
A
-
Q
L
W
G
-
V
N
V
-
L
--
G
L
R
E
-------
S
D
R
T
F
A
L
--
A
K
L
F
F
T
F
G
T
G
G
N
L
I
F
P
W
Y
V
G
A
S
C
V
L
F
---
P
G
--
A
A
----
R
V
--
A
S
N
V
L
S
T
I
S
R
--
F
K
P
----
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
-----
K
D
F
S
Q
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
A
W
-
K
-
E
A
T
G
V
-
D
------
I
I
D
G
I
G
C
T
E
-
N
F
------------
H
I
F
I
S
--------
N
R
P
---
G
D
I
----
R
P
G
------
S
S
G
K
P
V
E
G
Y
E
L
K
L
V
D
D
E
-
G
K
T
V
P
A
G
E
I
G
N
V
L
L
R
-----
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
-
Q
-
G
------------------
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
-
P
A
V
Q
--
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
-----------------
F
I
I
L
K
P
E
Q
I
P
S
-----
E
A
L
I
R
Q
I
T
D
H
C
T
E
K
M
A
A
Y
K
-
R
P
R
W
I
E
F
V
T
-------
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
---------------
34
PsiBlast_PDB
77.41
30%
-20
- C3 -
4FUQ
7
?
A:
[16-496]
--------------------------------------
P
H
K
L
A
I
E
T
A
----
A
---------
G
-----
D
K
I
S
Y
A
E
L
V
A
R
A
G
R
V
A
N
V
L
V
-
A
R
G
L
Q
V
G
D
R
V
A
A
Q
T
E
K
S
V
E
A
L
V
L
Y
L
A
T
V
R
A
G
G
V
Y
L
-
P
L
N
T
A
Y
T
L
H
E
L
D
Y
F
I
T
D
A
E
P
K
I
V
V
C
D
----------------------------------
P
S
K
R
D
G
I
A
A
I
A
A
K
V
G
A
T
V
E
--
T
L
G
P
D
G
R
G
S
L
T
D
A
A
A
---
G
---
A
------
S
E
A
F
A
T
I
D
R
---
G
A
D
D
L
A
A
I
L
Y
T
S
--
T
G
R
S
K
G
A
M
L
S
H
D
N
L
A
S
N
S
L
T
L
V
D
-
Y
W
R
-
F
--
T
P
D
D
---------
V
L
I
H
A
--
L
P
I
Y
H
T
H
G
L
F
V
A
S
N
V
T
L
F
A
R
G
S
M
I
F
L
---
P
K
--
F
D
----
P
D
--
K
I
--
L
D
L
--
M
--
A
R
A
----
T
V
L
M
G
V
P
T
F
Y
T
R
L
L
Q
S
-----
P
R
L
T
K
E
T
T
G
H
M
R
L
F
I
S
G
S
A
P
L
L
A
D
T
H
R
E
W
-
S
-
A
K
T
G
H
-
A
------
V
L
E
R
Y
G
M
T
E
-
T
N
------------
M
N
T
-
S
--------
N
P
Y
D
--
G
D
R
----
V
P
G
------
A
V
G
P
A
L
P
G
V
S
A
R
V
T
D
P
E
T
G
K
E
L
P
R
G
D
I
G
M
I
E
V
K
-----
G
P
N
V
F
K
G
Y
W
R
M
P
E
K
T
K
S
E
F
-
R
-
D
D-----------------
G
F
F
I
T
G
D
L
G
K
I
D
E
R
G
Y
V
H
I
L
G
R
G
K
D
L
V
I
T
G
G
F
N
V
Y
P
K
E
I
E
S
E
I
D
A
M
-
P
G
V
V
--
E
S
A
V
I
G
V
P
H
A
D
F
G
E
G
V
T
A
-----------------
V
V
V
R
D
K
G
---
A
-----
T
I
D
E
A
Q
V
L
H
G
L
D
G
Q
L
A
K
F
K
-
M
P
K
K
V
I
F
V
D
-------
D
L
P
R
N
T
M
G
K
V
Q
K
N
V
L
R
E
-------------
9
HHSearch
76.76
29%
-12
- C3 -
3C5E
7
ACS2A_HUMAN
A:
[54-561]
-----------------------------------
G
K
R
P
P
S
P
A
L
-
W
W
----
V
---------
N
GKG
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
-
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
I
Q
--
E
V
D
T
V
-
A
S
E
C
P
--
S
L
R
I
K
L
L
V
S
E
K
S
C
--------------------------
D
G
W
L
N
F
K
K
L
L
N
---
E
---
A
------
S
T
T
H
-
H
-
C
V
E
T
-
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
-
K
M
D
A
-
G
W
T
-
G
----
L
Q
------
A
S
D
I
M
W
T
I
--
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
LL-
P
K
--
F
D
----
P
L
--
V
I
--
L
K
T
L
S
S
--
Y
P
I
----
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
-----
D
L
-
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
-
R
-
A
Q
T
G
L
-
D
------
I
R
E
S
Y
G
Q
T
E
-
T
G
------------
L
T
C
M
V
--------
S
K
T
---
M
K
I
----
K
P
G
------
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
-
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
R
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
-
R
-
G
------------------
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
-
P
A
V
V
--
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
-----------------
F
V
V
L
A
S
Q
---
F
LSHD
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
-
Y
P
R
K
I
E
F
V
L
-------
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
----------
51
PsiBlast_PDB
76.13
27%
-22
- C3 -
4ZJZ
6
?
A:
[27-520]
--------------------------------------
P
D
K
T
A
F
-
V
D
----
D
---------
I
-----
S
S
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
-
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
-
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
V
L
K
A
A
L
T
-
K
S
D
-
H
--
E
V
Q
R
V
I
V
S
R
-------------
P
A
A
P
L
E
P
G
E
V
D
--
F
A
E
F
V
G
A
H
A
-----------------------
P
L
E
K
P
A
A
T
-
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
-
E
L
Y
G
-
R
N
T
-
L
--
H
L
R
E
------
D
-
D
V
C
F
S
A
--
A
K
L
F
F
A
Y
G
L
G
N
A
L
T
F
P
M
T
V
G
A
T
T
L
L
M
GER
P
T
--
P
D
----
A
V
F
K
R
W
--
L
G
G
V
G
G
--
V
K
P
----
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
-----
P
N
L
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
-
Q
-
R
H
F
G
L
-
D
------
I
V
D
G
I
G
S
T
E
-
M
L
------------
H
I
F
L
S
--------
N
L
P
---
D
R
V
----
R
Y
G
------
T
T
G
W
P
V
P
G
Y
Q
I
E
L
R
G
D
G
G
G
P
V
A
D
G
-
E
P
G
D
L
Y
I
H
-----
G
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
R
D
T
F
-
Q
-
G
------------------
G
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
-
P
G
V
L
--
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
-----------------
Y
V
V
P
R
P
G
---
Q
-----
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
A
P
Y
K
-
Y
P
R
S
T
V
F
V
A
-------
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
E
-------------
23
HHSearch
76.04
28%
-23
- C3 -
4RLQ
4
?
A:
[7-517]
----------------------
K
F
N
-
F
A
E
H
L
L
Q
T
N
R
V
R
P
D
K
T
A
F
-
V
D
----
D
---------
I
-----
S
S
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
-
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
-
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
--
V
L
K
A
A
-
L
T
K
-
S
DH
E
V
Q
R
V
I
V
S
R
P
A
A
------------------------
P
L
E
P
G
E
V
D
F
A
E
F
V
G
---
A
---
H
------
A
P
-
L
E
K
-
P
A
A
T
-
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
-
E
L
Y
G
-
R
N
T
-
L
---
H
L
R
------
E
D
D
V
C
F
S
A
--
A
K
L
F
F
A
Y
G
L
G
N
A
L
T
F
P
M
T
V
G
A
T
T
L
L
M
---
G
E
R-
P
T
P
D
A
V
F
K
--
R
W
--
L
G
G
V
G
G
--
V
K
P
----
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
-----
P
N
L
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
-
Q
-
R
H
F
G
L
-
D
------
I
V
D
G
I
G
S
T
E
-
M
L
------------
H
I
F
L
S
--------
N
L
P
---
D
R
V
----
R
Y
G
------
T
T
G
W
P
V
P
G
Y
Q
I
E
L
R
G
D
G
-
G
G
P
V
A
D
G
E
P
G
D
L
Y
I
H
-----
G
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
R
D
T
F
-
Q
-
G
------------------
G
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
-
P
G
V
L
--
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
-----------------
Y
V
V
P
R
P
G
---
Q
-----
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
A
P
Y
K
-
Y
P
R
S
T
V
F
V
A
-------
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
E
G
V
-----------
49
PsiBlast_PDB
75.55
27%
-21
- C3 -
4EAT
3
?
A:
[27-520]
--------------------------------------
P
D
K
T
A
F
-
V
D
----
D
---------
I
-----
S
S
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
-
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
-
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
V
L
K
A
A
L
T
-
K
S
D
-
H
--
E
V
Q
R
V
I
V
S
R
-------------
P
A
A
P
L
E
P
G
E
V
D
--
F
A
E
F
V
G
A
H
A
-----------------------
P
L
E
K
P
A
A
T
-
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
-
E
L
Y
G
-
R
N
T
-
L
--
H
L
R
E
------
D
-
D
V
C
F
S
A
--
A
K
L
F
F
A
Y
G
L
G
N
A
L
T
F
P
M
T
V
G
A
T
T
L
L
M
GER
P
T
--
P
D
----
A
V
F
K
R
W
--
L
G
G
V
G
G
--
V
K
P
----
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
-----
P
N
L
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
-
Q
-
R
H
F
G
L
-
D
------
I
V
D
G
I
G
S
T
E
-
M
L
------------
H
I
F
L
S
--------
N
L
P
---
D
R
V
----
R
Y
G
------
T
T
G
W
P
V
P
G
Y
Q
I
E
L
R
G
D
G
G
G
P
V
A
D
G
-
E
P
G
D
L
Y
I
H
-----
G
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
R
D
T
F
-
Q
-
G
------------------
G
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
-
P
G
V
L
--
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
-----------------
Y
V
V
P
R
P
G
---
Q
-----
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
A
P
Y
K
-
Y
P
R
S
T
V
F
V
A
-------
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
E
-------------
53
PsiBlast_PDB
75.31
27%
-24
- C3 -
4RM3
1
?
A:
[23-516]
--------------------------------------
P
D
K
T
A
F
-
V
D
----
D
---------
I
-----
S
S
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
-
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
-
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
V
L
K
A
A
L
T
-
K
S
D
-
H
--
E
V
Q
R
V
I
V
S
R
-------------
P
A
A
P
L
E
P
G
E
V
D
--
F
A
E
F
V
G
A
H
A
-----------------------
P
L
E
K
P
A
A
T
-
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
-
E
L
Y
G
-
R
N
T
-
L
--
H
L
R
E
------
D
-
D
V
C
F
S
A
--
A
K
L
F
F
A
Y
G
L
G
N
A
L
T
F
P
M
T
V
G
A
T
T
L
L
M
GER
P
T
--
P
D
----
A
V
F
K
R
W
--
L
G
G
V
G
G
--
V
K
P
----
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
-----
P
N
L
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
-
Q
-
R
H
F
G
L
-
D
------
I
V
D
G
I
G
S
T
E
-
M
L
------------
H
I
F
L
S
--------
N
L
P
---
D
R
V
----
R
Y
G
------
T
T
G
W
P
V
P
G
Y
Q
I
E
L
R
G
D
G
G
G
P
V
A
D
G
-
E
P
G
D
L
Y
I
H
-----
G
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
R
D
T
F
-
Q
-
G
------------------
G
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
-
P
G
V
L
--
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
-----------------
Y
V
V
P
R
P
G
---
Q
-----
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
A
P
Y
K
-
Y
P
R
S
T
V
F
V
A
-------
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
E
-------------
50
PsiBlast_PDB
75.22
27%
-22
- C3 -
4RMN
3
?
A:
[27-520]
--------------------------------------
P
D
K
T
A
F
-
V
D
----
D
---------
I
-----
S
S
L
S
F
A
Q
L
E
A
Q
T
R
Q
L
A
A
A
L
R
-
A
I
G
V
K
R
E
E
R
V
L
L
L
M
L
D
G
T
D
W
P
V
A
F
L
G
A
I
Y
A
G
I
V
P
V
-
A
V
N
T
L
L
T
A
D
D
Y
A
Y
M
L
E
H
S
R
A
Q
A
V
L
V
S
G
A
L
H
P
V
L
K
A
A
L
T
-
K
S
D
-
H
--
E
V
Q
R
V
I
V
S
R
-------------
P
A
A
P
L
E
P
G
E
V
D
--
F
A
E
F
V
G
A
H
A
-----------------------
P
L
E
K
P
A
A
T
-
Q
A
D
D
P
A
F
W
L
Y
S
S
G
S
T
G
R
P
K
G
V
V
H
T
H
A
N
P
Y
W
T
S
-
E
L
Y
G
-
R
N
T
-
L
--
H
L
R
E
------
D
-
D
V
C
F
S
A
--
A
K
L
F
F
A
Y
G
L
G
N
A
L
T
F
P
M
T
V
G
A
T
T
L
L
M
GER
P
T
--
P
D
----
A
V
F
K
R
W
--
L
G
G
V
G
G
--
V
K
P
----
T
V
F
Y
G
A
P
T
G
Y
A
G
M
L
A
A
-----
P
N
L
P
S
R
D
Q
V
A
L
R
L
A
S
S
A
G
E
A
L
P
A
E
I
G
Q
R
F
-
Q
-
R
H
F
G
L
-
D
------
I
V
D
G
I
G
S
T
E
-
M
L
------------
H
I
F
L
S
--------
N
L
P
---
D
R
V
----
R
Y
G
------
T
T
G
W
P
V
P
G
Y
Q
I
E
L
R
G
D
G
G
G
P
V
A
D
G
-
E
P
G
D
L
Y
I
H
-----
G
P
S
S
A
T
M
Y
W
G
N
R
A
K
S
R
D
T
F
-
Q
-
G
------------------
G
W
T
K
S
G
D
K
Y
V
R
N
D
D
G
S
Y
T
Y
A
G
R
T
D
D
M
L
K
V
S
G
I
Y
V
S
P
F
E
I
E
A
T
L
V
Q
H
-
P
G
V
L
--
E
A
A
V
V
G
V
A
D
E
H
G
L
T
K
P
K
A
-----------------
Y
V
V
P
R
P
G
---
Q
-----
T
L
S
E
T
E
L
K
T
F
I
K
D
R
L
A
P
Y
K
-
Y
P
R
S
T
V
F
V
A
-------
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
E
-------------
26
Fugue
74.49
28%
0
- C3 -
5EY9
5
FAA32_MYCMM
A:
[3-626]
--------
Y
H
N
P
F
I
V
N
G
K
I
R
F
P
E
N
T
N
L
V
R
H
V
E
K
W
A
R
V
R
G
D
K
L
A
Y
-
R
F
----
L
DFSTERD
G
V
E
-----
R
D
I
L
W
S
E
F
S
A
R
N
R
A
V
G
A
R
L
Q
-
Q
V
T
-
Q
P
G
D
R
I
A
I
L
C
P
Q
N
L
D
Y
L
I
S
F
F
G
A
L
Y
S
G
R
I
A
V
P
L
F
D
P
A
E
H
V
G
R
L
H
A
V
L
D
D
C
T
P
S
T
I
L
T
-----------------------------
T
T
D
S
A
E
G
V
R
K
F
I
R
S
R
S
A
K
E
R
P
R
V
I
A
--
V
D
A
V
-------------------------
P
T
E
V
A
S
T
W
Q
Q
P
-
N
E
L
T
T
A
Y
L
Q
Y
T
-----
V
P
S
G
V
Q
I
T
H
L
N
L
P
T
N
V
-
L
Q
V
L
-
N
A
L
-------
E
------
G
Q
E
G
D
R
G
V
S
W
L
P
F
F
H
D
M
G
L
I
T
V
L
L
A
S
V
L
-
G
H
S
F
T
F
M
T
--
P
A
--
A
F
----
V
R
--
R
P
--
G
R
W
I
R
E
L
A
R
K
P
GET
G
G
T
F
S
A
A
P
N
F
A
F
E
H
A
A
M
RGVPR
D
D
E
P
P
L
D
L
S
N
V
K
G
I
L
N
G
S
E
P
V
S
P
A
S
M
R
K
F
-
F
-
K
A
F
E
P
-
Y
GLRETA
V
K
P
S
Y
G
L
A
E
-
A
T
LFVSTTPMDE
V
P
T
V
I
H
V
D
R
D
E
L
N
K
Q
R
F
V
E
--
V
A
A
----
D
A
P
N
A
V
A
Q
V
S
A
G
K
V
G
V
D
E
W
A
V
I
V
D
T
E
T
A
S
E
L
P
D
G
Q
I
G
E
I
W
L
H
-----
G
N
N
L
G
I
G
Y
W
G
K
E
E
E
S
A
Q
T
F
-
R
-
N
ILKSRVPESHAEGAPDD
G
L
W
V
R
T
G
D
Y
G
T
Y
F
K
-
G
H
L
Y
I
A
G
R
I
K
D
L
V
I
I
D
G
R
N
H
Y
P
Q
D
L
E
Y
T
A
Q
E
S
T
K
A
L
R
VG
Y
V
A
A
F
S
V
P
A
N
Q
L
P
Q
K
V
F
D
DPHAGLSFDPEDT
S
E
Q
L
V
I
V
G
E
R
A
---
A
-----
G
T
H
K
L
E
Y
Q
P
I
A
D
D
I
R
A
A
I
A
-
V
G
H
G
V
T
V
R
D
V
L
L
V
S
A
G
T
I
P
R
T
S
S
G
K
I
G
R
R
A
C
R
T
A
Y
I
D
G
SLRS
T
V
F
A