@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28620: (2016-07-15 )
MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTITAYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEVGTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVLKNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLKGRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDEAAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS
Atome Classification :
(20 SA)
.........10........20....--....30........40........50.....------...60........70........80........90........100.......110.......120.......130.......140...---....150---.-.--.....160.......170.........180.......190..-..--...200---........-210........220------.-..-.....230-----........240.......250.......--260.-......270.......280--..----.....--..290.......300.......310.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSH
S
V
I
K
V
S
L
S
A
I
D
Q
M
K
M
T
YSGS
L
T
--ASVPQG
A
V
F
QAKPP
G
C
T
I
T
A
YQS
G
K
V
L
F
QGK------NAAAESARWGTAE
P
Q
E
K
K
KTAKKPADPRYAPPADIA
G
M
S
V
IGSDEVGTGDYFG
P
M
T
V
V
C
A
Y
V
D
K
T
M
L
P
L
M
K
E
LGVKDSKDLKD
P
Q
I
I
E
I
---
A
R
N
L
I
K
T---I-P--
Y
S
L
L
V
L
KNEKY
N
S
M
Q
E
--KGMSQ
G
K
M
K
A
L
L
H
N
Q
A
I
T
H
L
L
R
K
L-DG--VKP
E
A
----
I
L
I
DQFAE-P-G
V
Y
F
NHLKG
R
D
-------
I
-
V
K
-ERTYFST------KAE
G
I
H
L
A
V
A
A
A
S
I
I
A
R
Y
S
F
L
M
E
M
D
K
L
S
--
R
AAG-MTLPKGAGP
H
V
D
E
A
A
A
K
----
L
I
----
L
K
K
G
A
--
S
A
L
R
T
F
T
K
L
HFA
N
T
Q
K
A
Q
R
L
A
DKKRS
1
PsiBlast_PDB
89.27
46%
-74
- C3 -
2D0A
-
?
A:
[2-309]
-
S
N
Y
V
I
Q
A
D
Q
Q
L
L
D
A
L
R
A
H
Y
E
G
A
L
S
--
D
R
L
P
A
G
A
L
F
A
V
K
R
P
D
V
V
I
T
A
Y
R
S
G
K
V
L
F
Q
G
K
------
A
A
E
Q
E
A
A
K
W
I
S
G
A
S
A
S
N
E
T
A
D
H
Q
P
S
---
A
L
A
A
H
Q
L
G
S
L
S
A
I
G
S
D
E
V
G
T
G
D
Y
F
G
P
I
V
V
A
A
A
Y
V
D
R
P
H
I
A
K
I
A
A
L
G
V
K
D
S
K
Q
L
N
D
E
A
I
K
R
I
---
A
P
A
I
M
E
T
---
V
-
P
--
H
A
V
T
V
L
D
N
P
Q
Y
N
R
W
Q
R
--
S
G
M
P
Q
T
K
M
K
A
L
L
H
N
R
T
L
V
K
L
V
D
A
I
-
A
P
--
A
E
P
E
A
----
I
I
I
D
E
F
L
K
-
R
-
D
S
Y
F
R
Y
L
S
D
E
D
R------
I
-
I
R
-
E
R
V
H
C
L
P
------
K
A
E
S
V
H
V
S
V
A
A
A
S
I
I
A
R
Y
V
F
L
E
E
M
E
Q
L
S
--
R
A
V
G
-
L
L
L
P
K
G
A
G
A
I
V
D
E
A
A
A
R
----
I
I
----
R
A
R
G
E
--
E
M
L
E
T
C
A
K
L
H
F
A
N
T
K
K
A
L
A
I
A
K
R
R
--
21
Fugue
89.14
47%
-79
- C3 -
3ASM
-
?
A:
[2-309]
-
S
N
Y
V
I
Q
A
D
Q
Q
L
L
D
A
L
R
A
H
Y
E
G
A
L
S
--
D
R
L
P
A
G
A
L
F
A
V
K
R
P
D
V
V
I
T
A
Y
R
S
G
K
V
L
F
A
G
K
------
A
A
E
Q
E
A
A
K
W
I
---
S
G
A
S
A
S
N
E
T
A
D
H
Q
P
S
A
L
A
A
H
Q
L
G
S
L
S
A
I
G
S
D
E
V
G
T
G
D
Y
F
G
P
I
V
V
A
A
A
Y
V
D
R
P
H
I
A
K
I
A
A
L
G
V
K
D
S
K
Q
L
N
D
E
A
I
K
R
I
---
A
P
A
I
M
E
T
---
V
-
P
--
H
A
V
T
V
L
D
N
P
Q
Y
N
R
W
Q
R
--
S
G
M
P
Q
T
K
M
K
A
L
L
H
N
R
T
L
V
K
L
V
D
A
I
-
A
P
--
A
E
P
E
A
----
I
I
I
D
E
F
L
K
-
R
-
D
S
Y
F
R
Y
L
S
D
E
D
R------
I
-
I
R
-
E
R
V
H
C
L
P
------
K
A
E
S
V
H
V
S
V
A
A
A
S
I
I
A
R
Y
V
F
L
E
E
M
E
Q
L
S
--
R
A
V
G
-
L
L
L
P
K
G
A
G
A
I
V
D
E
A
A
A
R
----
I
I
----
R
A
R
G
E
--
E
M
L
E
T
C
A
K
L
H
F
A
N
T
K
K
A
L
A
I
A
K
R
R
--
31
HHSearch
88.41
47%
-77
- C3 -
2D0B
1
?
A:
[2-309]
-
S
N
Y
V
I
Q
A
D
Q
Q
L
L
D
A
L
R
A
H
Y
E
G
A
L
S
--
D
R
L
P
A
G
A
L
F
A
V
K
R
P
D
V
V
I
T
A
Y
R
S
G
K
V
L
F
Q
G
K
------
A
A
E
Q
E
A
A
K
W
I
S
G
A
S
A
S
N
E
T
A
---
D
H
Q
P
S
A
L
A
A
H
Q
L
G
S
L
S
A
I
G
S
D
E
V
G
T
G
D
Y
F
G
P
I
V
V
A
A
A
Y
V
D
R
P
H
I
A
K
I
A
A
L
G
V
K
D
S
K
Q
L
N
D
E
A
I
K
R
I
---
A
P
A
I
M
E
T
---
V
-
P
--
H
A
V
T
V
L
D
N
P
Q
Y
N
R
W
Q
R
--
S
G
M
P
Q
T
K
M
K
A
L
L
H
N
R
T
L
V
K
L
V
D
A
I
-
A
P
--
A
E
P
E
A
----
I
I
I
D
E
F
L
K
-
R
-
D
S
Y
F
R
Y
L
S
D
E
D
-------
R
I
I
R
-
E
R
V
H
C
L
P
------
K
A
E
S
V
H
V
S
V
A
A
A
S
I
I
A
R
Y
V
F
L
E
E
M
E
Q
L
S
--
R
A
V
G
-
L
L
L
P
K
G
A
G
A
I
V
D
E
A
A
A
R
----
I
I
----
R
A
R
G
E
--
E
M
L
E
T
C
A
K
L
H
F
A
N
T
K
K
A
L
A
I
A
K
R
R
--
3
PsiBlast_PDB
88.23
46%
-75
- C3 -
2D0C
1
?
A:
[2-309]
-
S
N
Y
V
I
Q
A
D
Q
Q
L
L
D
A
L
R
A
H
Y
E
G
A
L
S
--
D
R
L
P
A
G
A
L
F
A
V
K
R
P
D
V
V
I
T
A
Y
R
S
G
K
V
L
F
Q
G
K
------
A
A
E
Q
E
A
A
K
W
I
S
G
A
S
A
S
N
E
T
A
D
H
Q
P
S
---
A
L
A
A
H
Q
L
G
S
L
S
A
I
G
S
D
E
V
G
T
G
D
Y
F
G
P
I
V
V
A
A
A
Y
V
D
R
P
H
I
A
K
I
A
A
L
G
V
K
D
S
K
Q
L
N
D
E
A
I
K
R
I
---
A
P
A
I
M
E
T
---
V
-
P
--
H
A
V
T
V
L
D
N
P
Q
Y
N
R
W
Q
R
--
S
G
M
P
Q
T
K
M
K
A
L
L
H
N
R
T
L
V
K
L
V
D
A
I
-
A
P
--
A
E
P
E
A
----
I
I
I
D
E
F
L
K
-
R
-
D
S
Y
F
R
Y
L
S
D
E
D
R------
I
-
I
R
-
E
R
V
H
C
L
P
------
K
A
E
S
V
H
V
S
V
A
A
A
S
I
I
A
R
Y
V
F
L
E
E
M
E
Q
L
S
--
R
A
V
G
-
L
L
L
P
K
G
A
G
A
I
V
D
E
A
A
A
R
----
I
I
----
R
A
R
G
E
--
E
M
L
E
T
C
A
K
L
H
F
A
N
T
K
K
A
L
A
I
A
K
R
R
--
4
PsiBlast_PDB
88.19
46%
-79
- C3 -
3ASM
-
?
A:
[2-309]
-
S
N
Y
V
I
Q
A
D
Q
Q
L
L
D
A
L
R
A
H
Y
E
G
A
L
S
--
D
R
L
P
A
G
A
L
F
A
V
K
R
P
D
V
V
I
T
A
Y
R
S
G
K
V
L
F
A
G
K
------
A
A
E
Q
E
A
A
K
W
I
S
G
A
S
A
S
N
E
T
A
D
H
Q
P
S
---
A
L
A
A
H
Q
L
G
S
L
S
A
I
G
S
D
E
V
G
T
G
D
Y
F
G
P
I
V
V
A
A
A
Y
V
D
R
P
H
I
A
K
I
A
A
L
G
V
K
D
S
K
Q
L
N
D
E
A
I
K
R
I
---
A
P
A
I
M
E
T
---
V
-
P
--
H
A
V
T
V
L
D
N
P
Q
Y
N
R
W
Q
R
--
S
G
M
P
Q
T
K
M
K
A
L
L
H
N
R
T
L
V
K
L
V
D
A
I
-
A
P
--
A
E
P
E
A
----
I
I
I
D
E
F
L
K
-
R
-
D
S
Y
F
R
Y
L
S
D
E
D
R------
I
-
I
R
-
E
R
V
H
C
L
P
------
K
A
E
S
V
H
V
S
V
A
A
A
S
I
I
A
R
Y
V
F
L
E
E
M
E
Q
L
S
--
R
A
V
G
-
L
L
L
P
K
G
A
G
A
I
V
D
E
A
A
A
R
----
I
I
----
R
A
R
G
E
--
E
M
L
E
T
C
A
K
L
H
F
A
N
T
K
K
A
L
A
I
A
K
R
R
--
2
PsiBlast_PDB
87.90
46%
-77
- C3 -
2D0B
1
?
A:
[2-309]
-
S
N
Y
V
I
Q
A
D
Q
Q
L
L
D
A
L
R
A
H
Y
E
G
A
L
S
--
D
R
L
P
A
G
A
L
F
A
V
K
R
P
D
V
V
I
T
A
Y
R
S
G
K
V
L
F
Q
G
K
------
A
A
E
Q
E
A
A
K
W
I
S
G
A
S
A
S
N
E
T
A
D
H
Q
P
S
---
A
L
A
A
H
Q
L
G
S
L
S
A
I
G
S
D
E
V
G
T
G
D
Y
F
G
P
I
V
V
A
A
A
Y
V
D
R
P
H
I
A
K
I
A
A
L
G
V
K
D
S
K
Q
L
N
D
E
A
I
K
R
I
---
A
P
A
I
M
E
T
---
V
-
P
--
H
A
V
T
V
L
D
N
P
Q
Y
N
R
W
Q
R
--
S
G
M
P
Q
T
K
M
K
A
L
L
H
N
R
T
L
V
K
L
V
D
A
I
-
A
P
--
A
E
P
E
A
----
I
I
I
D
E
F
L
K
-
R
-
D
S
Y
F
R
Y
L
S
D
E
D
R------
I
-
I
R
-
E
R
V
H
C
L
P
------
K
A
E
S
V
H
V
S
V
A
A
A
S
I
I
A
R
Y
V
F
L
E
E
M
E
Q
L
S
--
R
A
V
G
-
L
L
L
P
K
G
A
G
A
I
V
D
E
A
A
A
R
----
I
I
----
R
A
R
G
E
--
E
M
L
E
T
C
A
K
L
H
F
A
N
T
K
K
A
L
A
I
A
K
R
R
--
22
Fugue
87.63
47%
-74
- C3 -
2D0B
1
?
A:
[2-309]
-
S
N
Y
V
I
Q
A
D
Q
Q
L
L
D
A
L
R
A
H
Y
E
G
A
L
S
--
D
R
L
P
A
G
A
L
F
A
V
K
R
P
D
V
V
I
T
A
Y
R
S
G
K
V
L
F
Q
G
K
------
A
A
E
Q
E
A
A
K
W
I
S
G
A
S
A
S
N
E
T
A
D
H
Q
P
S
A
L
A
A
H
Q
L
G
S
---
L
S
A
I
G
S
D
E
V
G
T
G
D
Y
F
G
P
I
V
V
A
A
A
Y
V
D
R
P
H
I
A
K
I
A
A
L
G
V
K
D
S
K
Q
L
N
D
E
A
I
K
R
I
---
A
P
A
I
M
E
T
---
V
-
P
--
H
A
V
T
V
L
D
N
P
Q
Y
N
R
W
Q
R
--
S
G
M
P
Q
T
K
M
K
A
L
L
H
N
R
T
L
V
K
L
V
D
A
I
-
A
P
--
A
E
P
E
A
----
I
I
I
D
E
F
L
K
-
R
-
D
S
Y
F
R
Y
L
S
D
E
D
-------
R
I
I
R
-
E
R
V
H
C
L
P
------
K
A
E
S
V
H
V
S
V
A
A
A
S
I
I
A
R
Y
V
F
L
E
E
M
E
Q
L
S
--
R
A
V
G
-
L
L
L
P
K
G
A
G
A
I
V
D
E
A
A
A
R
----
I
I
----
R
A
R
G
E
--
E
M
L
E
T
C
A
K
L
H
F
A
N
T
K
K
A
L
A
I
A
K
R
R
--
33
HHSearch
53.80
28%
62
* C3 *
4PY5
10
?
A:
[1-267]
----
S
M
K
L
S
S
S
E
K
E
K
L
L
K
K
L
K
A
L
G
A
K
E
E
K
P
P
E
H
A
Q
Y
R
L
R
L
N
D
A
I
L
T
V
Y
K
S
G
S
V
V
Y
G
G
K
------
G
R
E
K
L
K
E
L
V
----
A
E
---------------
T
V
L
S
D
T
E
L
P
R
I
G
C
N
E
A
G
K
G
E
F
V
G
P
L
V
V
A
C
I
V
A
D
E
K
C
L
K
R
L
I
E
L
G
V
K
D
S
K
K
L
S
N
E
K
V
E
E
L
---
A
S
E
I
T
E
T
---
C
-
H
--
G
K
V
K
L
L
I
P
E
K
Y
N
R
A
Y
S
--
K
F
K
N
I
N
R
L
L
E
A
V
Y
R
E
I
V
S
D
L
C
E
K
F
------
S
P
K
V
----
V
V
V
D
K
F
S
N
-
R
-
A
--
E
E
V
L
K
D
V
V
---------
K
G
-
A
R
L
E
V
R
P
------
K
A
E
-
D
D
L
A
V
A
A
A
S
I
V
A
K
A
V
R
L
K
T
M
K
E
L
E
--
K
R
F
K
-
V
K
L
P
E
G
N
T
G
L
-----
A
E
----
L
L
----
K
K
T
P
K
--
E
L
H
E
K
L
F
K
L
H
F
S
V
-------------
32
HHSearch
52.90
26%
0
- C3 -
3VN5
-
RNH3_AQUAE
A:
[2-256]
---
P
S
L
K
I
S
P
S
E
A
E
K
I
Q
N
Y
L
V
S
S
G
F
R
-
K
I
N
A
P
Y
T
L
W
A
L
E
G
N
G
V
K
V
Y
Y
Y
K
T
G
S
L
L
I
Q
G
K
------
N
S
E
K
V
L
K
E
V
L
N
----------------------
L
L
E
K
K
K
L
P
G
C
D
E
S
G
K
G
D
I
F
G
S
L
V
L
C
C
V
C
I
P
E
E
N
Y
L
K
V
S
S
L
N
P
R
D
T
K
R
L
S
D
K
R
V
E
R
L
---
Y
L
A
L
K
P
L
---
V
-
K
--
A
Y
C
Y
E
I
K
P
E
E
Y
N
K
L
Y
R
--
K
F
R
N
L
N
K
M
M
T
H
F
Y
K
L
L
I
E
R
V
K
E
E
C
------
G
V
S
E
----
V
V
V
D
K
Y
Q
P
-
S
-
N
P
F
------------------
G
-
E
D
V
I
F
E
T
------
E
A
E
-
R
N
L
A
V
A
V
A
S
I
F
A
R
Y
K
F
L
Q
S
L
K
E
V
E
--
R
E
L
G
-
I
K
I
P
K
G
T
S
K
E
V
K
E
L
A
K
S
----
L
K
----
N
--------
P
E
R
F
I
K
L
N
F
N
--------------
5
PsiBlast_PDB
50.68
27%
61
- C3 -
4PY5
10
?
A:
[27-266]
------------------------------
P
E
H
A
Q
Y
R
L
R
L
N
D
A
I
L
T
V
Y
K
S
G
S
V
V
Y
G
G
K
GR
E
K
L
K
E
L
V
A
E
T
V
L
S
D
T
E
L
P
R
-------------------------
I
G
C
N
E
A
G
K
G
E
F
V
G
P
L
V
V
A
C
I
V
A
D
E
K
C
L
K
R
L
I
E
L
G
V
K
D
S
K
K
L
S
N
E
K
V
E
E
L
---
A
S
E
I
T
E
T
---
C
-
H
--
G
K
V
K
L
L
I
P
E
K
Y
N
R
A
Y
S
--
K
F
K
N
I
N
R
L
L
E
A
V
Y
R
E
I
V
S
D
L
C
E
K
F
-
S
-----
P
K
V
----
V
V
V
D
K
F
S
N
-
R
-
A
E
E
V
L
----
K
D
-------
V
-
V
K
G
A
R
L
E
V
R
P
------
K
A
E
D
-
D
L
A
V
A
A
A
S
I
V
A
K
A
V
R
L
K
T
M
K
E
L
E
--
K
R
F
K
-
V
K
L
P
E
G
-----
N
T
G
L
A
E
----
L
L
----
K
K
T
P
K
--
E
L
H
E
K
L
F
K
L
H
F
S
--------------
6
PsiBlast_PDB
50.46
28%
-32
- C3 -
3VN5
-
RNH3_AQUAE
A:
[39-255]
-----------------------------------------
G
V
K
V
Y
Y
Y
K
T
G
S
L
L
I
Q
G
K
------
N
S
--
E
K
V
L
K
E
V
L
N
L
L
E
K
K
K
L
P
--------------------
G
C
D
E
S
G
K
G
D
I
F
G
S
L
V
L
C
C
V
C
I
P
E
E
N
Y
L
K
V
S
S
L
N
P
R
D
T
K
R
L
S
D
K
R
V
E
R
L
Y
L
A
L
K
P
L
V
K
A
---
Y
-
C
--
Y
E
I
---
K
P
E
E
Y
N
K
L
Y
R
--
K
F
R
N
L
N
K
M
--------
M
T
H
F
Y
K
L
L
I
E
R
--
V
K
E
E
C
GVS
E
V
V
V
D
K
Y
-
Q
-
P
-
S
N
P
F
----
G
E
D
-------
V
-
I
------
F
E
T
------
E
A
E
R
-
N
L
A
V
A
V
A
S
I
F
A
R
Y
K
F
L
Q
S
L
K
E
V
E
--
R
E
L
G
-
I
K
I
P
K
G
T
S
K
E
V
K
E
L
A
--------------
K
S
L
--
K
N
P
E
R
F
I
K
L
N
F
---------------
34
HHSearch
49.10
23%
-39
- C3 -
1EKE
1
RNH2_METJA
A:
[1-224]
-----------------------------------------------------------------------------------------------------
M
I
I
I
G
I
D
E
A
G
R
G
P
V
L
G
P
M
V
V
C
A
F
A
I
E
K
E
R
E
E
E
L
K
K
L
G
V
K
---
E
L
T
K
N
K
R
A
Y
L
---
K
K
L
L
E
N
L
---
G
-
Y
--
V
E
K
R
I
L
E
A
E
E
I
N
Q
L
M
N
---
S
I
N
L
N
D
I
E
I
N
A
F
S
K
V
A
K
N
L
I
E
K
L
-
N
I
R-
D
D
E
I
E
----
I
Y
I
D
A
C
S
T
-
N
T
K
K
F
E
D
S
F
K
D
K
I
EDIIKER
N
-
L
N
-
I
K
I
I
A
E
H
------
K
A
D
A
K
Y
P
V
V
S
A
A
S
I
I
A
K
A
E
R
D
E
I
I
D
Y
Y
K
--
K
I
Y
G
----
D
I
G
S
G
Y
P
S
D
P
K
T
I
K
----
F
L
----
E
D
Y
F
K
K
H
K
K
L
P
D
I
A
R
T
H
W
K
T
C
K
R
I
L
D
K
S
K
Q
---
36
HHSearch
48.58
23%
-41
- C3 -
1I39
-
RNH2_ARCFU
A:
[1-200]
------------------------------------------------------------------------------------------------------
M
K
A
G
I
D
E
A
G
K
G
C
V
I
G
P
L
V
V
A
G
V
A
C
S
D
E
--
D
R
L
R
K
L
G
V
K
D
S
K
K
L
S
Q
G
R
R
E
E
L
---
A
E
E
I
R
K
I
---
C
-
R
--
T
E
V
L
K
V
S
P
E
N
L
D
E
R
M
A
---
A
K
T
I
N
E
I
L
K
E
C
Y
A
E
I
I
L
R
L
K
----------
P
E
I
----
A
Y
V
D
S
P
D
V
I
P
-
E
R
L
S
R
E
L
E
E
I
T
----------
G
-
L
R
V
V
A
E
H
------
K
A
D
E
K
Y
P
L
V
A
A
A
S
I
I
A
K
V
E
R
E
R
E
I
E
R
L
K
--
E
K
F
G
----
D
F
G
S
G
Y
A
S
D
P
R
T
R
E
----
V
L
----
K
E
W
I
A
S
-
G
R
I
P
S
C
V
R
M
R
W
K
T
V
S
N
L
R
Q
K
------
7
PsiBlast_PDB
48.30
30%
-48
- C3 -
1UAX
-
RNH2_PYRHO
A:
[1-164]
-----------------------------------------------------------------------------------------------------
M
K
V
A
G
V
D
E
A
G
R
G
P
V
I
G
P
L
V
I
G
V
A
V
I
D
E
K
N
I
E
R
L
R
D
I
G
V
K
D
S
K
Q
L
T
P
G
Q
R
E
K
L
---
F
S
K
L
I
D
I
---
L
-
D
D
Y
Y
V
L
L
V
T
P
K
E
----
I
D
E
--
R
H
H
S
M
N
E
L
E
A
E
K
F
V
V
A
L
N
S
L
------
R
--
I
K
P
Q
K
----
I
Y
V
D
S
A
D
V
-
D
-
P
K
R
F
A
S
L
I
K
A
G
-------
L
-
K
Y
-
E
A
T
V
I
A
E
H
-----
K
A
D
A
K
Y
E
I
V
S
A
A
S
I
I
A
K
V
T
R
D
R
E
I
E
K
L
K
--
Q
K
Y
G
-------------------------------------------------------------
35
HHSearch
47.41
24%
-12
- C3 -
1IO2
-
RNH2_THEKO
A:
[1-211]
-----------------------------------------------------------------------------------------------------
M
K
I
A
G
I
D
E
A
G
R
G
P
V
I
G
P
M
V
I
A
A
V
V
V
D
E
N
S
L
P
K
L
E
E
L
K
V
R
D
S
K
K
L
T
P
K
R
R
E
K
L
---
F
N
E
I
L
G
V
---
L
D
D
--
Y
V
I
L
E
L
P
P
D
V
I
G
S
R
-----
E
G
T
L
N
E
F
E
V
E
N
F
A
K
A
L
N
S
L
K
V
--------
K
P
D
V
----
I
Y
A
D
A
A
D
V
D
E
-
E
R
F
A
R
E
L
G
E
R
L
-------
N
-
F
E
-
A
E
V
V
A
K
H
------
K
A
D
D
I
F
P
V
V
S
A
A
S
I
L
A
K
V
T
R
D
R
A
V
E
K
L
K
--
E
E
Y
G
----
E
I
G
S
G
Y
P
S
D
P
R
T
R
A
----
F
L
E
N
Y
Y
R
E
H
G
----
E
F
P
P
I
V
R
K
G
W
K
T
L
K
K
I
A
E
K
V
E
S
E
--
37
HHSearch
46.91
19%
-37
- C3 -
3KIO
-
RNH2A_MOUSE
A:
[21-249]
----------------------------------------------------------------------------------------------
P
A
V
C
L
K
E
P
C
V
L
G
V
D
E
A
G
R
G
P
V
L
G
P
M
V
Y
A
I
C
Y
C
P
L
S
R
L
A
D
L
E
A
L
K
V
A
D
--
T
L
T
E
N
E
R
E
R
L
---
F
A
K
M
E
E
D
GDF
V
-
G
--
W
A
L
D
V
L
S
P
N
L
I
S
T
S
M
L
GR
V
K
Y
N
L
N
S
L
S
H
D
T
A
A
G
L
I
Q
Y
A
L
D
Q
N
-----
V
N
V
T
Q
----
V
F
V
D
T
V
G
M
-
P
-
E
T
Y
Q
A
R
L
Q
Q
H
F
-------
P
--
G
-
I
E
V
T
V
K
A
------
K
A
D
S
L
F
P
V
V
S
A
A
S
I
F
A
K
V
A
R
D
K
A
V
K
N
W
Q
F
V
E
N
L
Q
D
L
D
S
D
Y
G
S
G
Y
P
N
D
P
K
T
K
A
----
W
L
----
R
K
H
V
D
PV
F
G
F
P
Q
F
V
R
F
S
W
S
T
A
Q
A
I
L
E
K
E
-----
38
HHSearch
46.30
25%
-11
- C3 -
1UAX
-
RNH2_PYRHO
A:
[1-208]
-----------------------------------------------------------------------------------------------------
M
K
V
A
G
V
D
E
A
G
R
G
P
V
I
G
P
L
V
I
G
V
A
V
I
D
E
K
N
I
E
R
L
R
D
I
G
V
K
D
S
K
Q
L
T
P
G
Q
R
E
K
L
---
F
S
K
L
I
D
I
---
L
D
D
--
Y
Y
V
L
L
V
T
P
K
E
I
D
E
R
H
-----
H
S
M
N
E
L
E
A
E
K
F
V
V
A
L
N
S
L
R
I
--------
K
P
Q
K
----
I
Y
V
D
S
A
D
V
D
P
-
K
R
F
A
S
L
I
K
A
G
L
-------
K
-
Y
E
-
A
T
V
I
A
E
H
------
K
A
D
A
K
Y
E
I
V
S
A
A
S
I
I
A
K
V
T
R
D
R
E
I
E
K
L
K
--
Q
K
Y
G
-
E
---
F
G
S
G
Y
P
S
D
P
R
T
K
E
W
L
E
E
Y
Y
----
K
Q
Y
G
----
D
F
P
P
I
V
R
R
T
W
E
T
A
R
K
I
E
E
R
F
-----
8
PsiBlast_PDB
44.26
29%
-56
- C3 -
1IO2
-
RNH2_THEKO
A:
[1-164]
-----------------------------------------------------------------------------------------------------
M
K
I
A
G
I
D
E
A
G
R
G
P
V
I
G
P
M
V
I
A
A
V
V
V
D
E
N
S
L
P
K
L
E
E
L
K
V
R
D
S
K
K
L
T
-
P
K
R
R
E
K
---
L
F
N
E
I
------------
L
G
V
L
D
D
--
Y
V
I
L
E
L
--
P
P
D
V
I
G
S
R
E
G
T
L
N
E
F
E
V
E
N
F
A
K
A
L
-
N
S
LK
V
K
P
D
V
----
I
Y
A
D
A
A
D
V
-
D
-
E
E
R
F
A
R
E
L
G
--------------
E
R
L
N
F
E
A
E
V
V
A
K
H
K
A
D
D
I
F
P
V
V
S
A
A
S
I
L
A
K
V
T
R
D
R
A
V
E
K
L
K
--
E
E
Y
G
-------------------------------------------------------------
9
PsiBlast_PDB
43.40
29%
-55
- C3 -
2DFH
-
RNH2_THEKO
A:
[1-164]
-----------------------------------------------------------------------------------------------------
M
K
I
A
G
I
D
E
A
G
R
G
P
V
I
G
P
M
V
I
A
A
V
V
V
D
E
N
S
L
P
K
L
E
E
L
K
V
R
D
S
K
K
L
T
-
P
K
R
R
E
K
---
L
F
N
E
I
------------
L
G
V
L
D
D
--
Y
V
I
L
E
L
--
P
P
D
V
I
G
S
R
E
G
T
L
N
E
F
E
V
E
N
F
A
K
A
L
-
N
S
LK
V
K
P
D
V
----
I
Y
A
D
A
A
D
V
-
D
-
E
E
R
F
A
R
E
L
G
--------------
E
R
L
N
F
E
A
E
V
V
A
K
H
K
A
D
D
I
F
P
V
V
S
A
A
S
I
L
A
K
V
T
R
D
R
A
V
E
K
L
K
--
E
E
Y
G
-------------------------------------------------------------
11
PsiBlast_PDB
42.89
29%
-63
- C3 -
2DFF
-
RNH2_THEKO
A:
[1-164]
-----------------------------------------------------------------------------------------------------
M
K
I
A
G
I
D
E
A
G
R
G
P
V
I
G
P
M
V
I
A
A
V
V
V
D
E
N
S
L
P
K
L
E
E
L
K
V
R
D
S
K
K
L
T
-
P
K
R
R
E
K
---
L
F
N
E
I
------------
L
G
V
L
D
D
--
Y
V
I
L
E
L
--
P
P
D
V
I
G
S
R
E
G
T
L
N
E
F
E
V
E
N
F
A
K
A
L
-
N
S
LK
V
K
P
D
V
----
I
Y
A
D
A
A
D
V
-
D
-
E
E
R
F
A
R
E
L
G
--------------
E
R
L
N
F
E
A
E
V
V
A
K
H
K
A
D
D
I
F
P
V
V
S
A
A
S
I
L
A
K
V
T
R
D
R
A
V
E
K
L
K
--
E
E
Y
G
-------------------------------------------------------------