@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29180: (2016-07-16 )
MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHGARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTDKISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNVPGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGAVLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQDITVDASRGAVYQGRASVL
Atome Classification :
(21 SA)
.........10........20........30........40........50.....------.-..60........70........80---........90.....-.-..100.--......110.......120.......130.......140.......150.......160.......170......-.180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.....--..350.........360.......370.......380.......390.......400.......410.......----420.......430.......440---........450.....-..-460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRK
T
K
I
V
C
T
IGP
A
S
E
S
I
E
M
L
T
K
L
M
ESGM
N
V
A
R
L
NFSHG
D
F
E
E
H
G
A
R
I
K
N
I
R
E
A
S
K
K
------L-GKNV
G
I
L
L
DTKGP
E
I
R
T
H
T
MENG
G
---
I
E
L
ETG
K
E
L
I
I
S
M
D
E
-V-VGTT
D
K
--
I
S
V
T
Y
E
G
L
V
H
D
V
EQG
S
T
I
L
LDDG
L
I
G
L
E
V
L
D
V
D
A
A
K
R
E
I
K
T
K
VLNNGTLKNKKGVNVPG
V
S
V
NLPGITEKDA
R
D
I
-
V
F
G
I
E
Q
G
V
D
F
I
A
P
S
F
I
RRST
D
V
L
E
I
R
E
L
L
E
EHNAQ
D
I
Q
I
I
P
KIENQEGV
D
N
I
D
A
I
L
EVSD
G
L
M
V
ARGDLGVEI
P
A
E
EVP
L
V
Q
K
E
L
I
K
K
C
N
ALGK
P
V
I
T
A
T
Q
M
L
D
S
M
QRNPRPTRA
E
A
S
D
V
A
N
A
I
FDGT
D
A
I
M
LSGETAAGSY
P
V
E
A
V
Q
T
M
H
N
I
A
SR
S
E
EAL
N
Y
K
E
I
L
S
K
--
R
R
D
--QVGM
T
I
T
D
A
I
G
Q
S
V
A
H
T
A
I
NLN
A
A
A
I
VTPTESG
H
T
A
R
M
I
A
KYRPQA
P
I
V
A
V
TVND
S
I
S
R
K
L
A
L
V
S
G
V
F
A----ESGQNAS
S
T
D
E
M
L
E
D
A
V
Q
K
S
L
N
----SGIVKHG
D
L
I
V
I
T
AGT-VG-ESGTT
N
L
M
K
V
H
T
V
G
D
I
I
AKGQGIGRKSAYG
P
V
V
V
AQ
N
A
K
E
A
E
Q
KMTD
G
A
V
L
V
TKST
D
R
D
M
I
A
S
L
E
K
A
S
A
L
I
TEEGGLT
S
H
A
A
V
V
G
LSLG
I
P
V
I
V
GLEN
A
T
S
ILTDG
Q
D
I
T
V
DASRG
A
V
YQGRASVL
106
HHSearch
92.87
72%
-62
- C7 -
2E28
1
KPYK_GEOSE
A:
[2-587]
K
R
K
T
K
I
V
S
T
I
G
P
A
S
E
S
V
D
K
L
V
Q
L
M
E
A
G
M
N
V
A
R
L
N
F
S
H
G
D
H
E
E
H
G
R
R
I
A
N
I
R
E
A
A
K
R
------
T
-
G
R
T
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
E
N
G
A
---
I
E
L
K
E
G
S
K
L
V
I
S
M
S
E
-
V
-
L
G
T
P
E
K
--
I
S
V
T
Y
P
S
L
I
D
D
V
S
V
G
A
K
I
L
L
D
D
G
L
I
S
L
E
V
N
A
V
D
K
Q
A
G
E
I
V
T
T
V
L
N
G
G
V
L
K
N
K
K
G
V
N
V
P
G
V
K
V
N
L
P
G
I
T
E
K
D
R
A
D
I
-
L
F
G
I
R
Q
G
I
D
F
I
A
A
S
F
V
R
R
A
S
D
V
L
E
I
R
E
L
L
E
A
H
D
A
L
H
I
Q
I
I
A
K
I
E
N
E
E
G
V
A
N
I
D
E
I
L
E
A
A
D
G
L
M
V
A
R
G
D
L
G
V
E
I
P
A
E
E
V
P
L
I
Q
K
L
L
I
K
K
S
N
M
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
P
T
R
A
E
A
S
D
V
A
N
A
I
F
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
Q
Y
P
V
E
A
V
K
T
M
H
Q
I
A
L
R
T
E
Q
A
L
E
H
R
D
I
L
S
Q
--
R
T
K
--
E
S
Q
T
T
I
T
D
A
I
G
Q
S
V
A
H
T
A
L
N
L
D
V
A
A
I
V
T
P
T
V
S
G
K
T
P
Q
M
V
A
K
Y
R
P
K
A
P
I
I
A
V
T
S
N
E
A
V
S
R
R
L
A
L
V
W
G
V
Y
T
----
K
E
A
P
H
V
N
T
T
D
E
M
L
D
V
A
V
D
A
A
V
R
----
S
G
L
V
K
H
G
D
L
V
V
I
T
A
G
V
-
P
V
G
E
T
G
S
T
N
L
M
K
V
H
V
I
S
D
L
L
A
K
G
Q
G
I
G
R
K
S
A
F
G
K
A
V
V
A
K
T
A
E
E
A
R
Q
K
M
V
D
G
G
I
L
V
T
V
S
T
D
A
D
M
M
P
A
I
E
K
A
A
A
I
I
T
E
E
G
G
L
T
S
H
A
A
V
V
G
L
S
L
G
I
P
V
I
V
G
V
E
N
A
T
T
L
F
K
D
G
Q
E
I
T
V
D
G
G
F
G
A
V
Y
R
G
H
A
S
V
L
1
PsiBlast_PDB
92.74
72%
-62
- C7 -
2E28
1
KPYK_GEOSE
A:
[3-587]
-
R
K
T
K
I
V
S
T
I
G
P
A
S
E
S
V
D
K
L
V
Q
L
M
E
A
G
M
N
V
A
R
L
N
F
S
H
G
D
H
E
E
H
G
R
R
I
A
N
I
R
E
A
A
K
R
------
T
-
G
R
T
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
E
N
G
A
---
I
E
L
K
E
G
S
K
L
V
I
S
M
S
E
-
V
-
L
G
T
P
E
K
--
I
S
V
T
Y
P
S
L
I
D
D
V
S
V
G
A
K
I
L
L
D
D
G
L
I
S
L
E
V
N
A
V
D
K
Q
A
G
E
I
V
T
T
V
L
N
G
G
V
L
K
N
K
K
G
V
N
V
P
G
V
K
V
N
L
P
G
I
T
E
K
D
R
A
D
I
-
L
F
G
I
R
Q
G
I
D
F
I
A
A
S
F
V
R
R
A
S
D
V
L
E
I
R
E
L
L
E
A
H
D
A
L
H
I
Q
I
I
A
K
I
E
N
E
E
G
V
A
N
I
D
E
I
L
E
A
A
D
G
L
M
V
A
R
G
D
L
G
V
E
I
P
A
E
E
V
P
L
I
Q
K
L
L
I
K
K
S
N
M
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
P
T
R
A
E
A
S
D
V
A
N
A
I
F
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
Q
Y
P
V
E
A
V
K
T
M
H
Q
I
A
L
R
T
E
Q
A
L
E
H
R
D
I
L
S
Q
--
R
T
K
--
E
S
Q
T
T
I
T
D
A
I
G
Q
S
V
A
H
T
A
L
N
L
D
V
A
A
I
V
T
P
T
V
S
G
K
T
P
Q
M
V
A
K
Y
R
P
K
A
P
I
I
A
V
T
S
N
E
A
V
S
R
R
L
A
L
V
W
G
V
Y
T
----
K
E
A
P
H
V
N
T
T
D
E
M
L
D
V
A
V
D
A
A
V
R
----
S
G
L
V
K
H
G
D
L
V
V
I
T
A
G
V
P
V
G
-
E
T
G
S
T
N
L
M
K
V
H
V
I
S
D
L
L
A
K
G
Q
G
I
G
R
K
S
A
F
G
K
A
V
V
A
K
T
A
E
E
A
R
Q
K
M
V
D
G
G
I
L
V
T
V
S
T
D
A
D
M
M
P
A
I
E
K
A
A
A
I
I
T
E
E
G
G
L
T
S
H
A
A
V
V
G
L
S
L
G
I
P
V
I
V
G
V
E
N
A
T
T
L
F
K
D
G
Q
E
I
T
V
D
G
G
F
G
A
V
Y
R
G
H
A
S
V
L
4
PsiBlast_PDB
86.83
62%
-63
- C7 -
3T0T
2
KPYK_STAAR
A:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
23
PsiBlast_CBE
86.52
62%
-63
- C7 -
3T0T
2
KPYK_STAAR
B:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
22
PsiBlast_CBE
86.50
62%
-62
- C7 -
3T0T
2
KPYK_STAAR
C:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
21
PsiBlast_CBE
86.06
62%
-63
- C7 -
3T0T
2
KPYK_STAAR
D:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
27
PsiBlast_CBE
85.93
62%
-63
- C7 -
3T05
1
KPYK_STAAR
D:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
25
PsiBlast_CBE
85.70
62%
-63
- C7 -
3T07
2
KPYK_STAAR
C:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
26
PsiBlast_CBE
85.66
62%
-64
- C7 -
3T07
2
KPYK_STAAR
B:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
24
PsiBlast_CBE
85.55
62%
-63
- C7 -
3T07
2
KPYK_STAAR
D:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
3
PsiBlast_PDB
85.54
62%
-64
- C7 -
3T07
2
KPYK_STAAR
A:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
28
PsiBlast_CBE
85.07
62%
-64
- C7 -
3T05
1
KPYK_STAAR
C:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
2
PsiBlast_PDB
84.99
62%
-63
- C7 -
3T05
1
KPYK_STAAR
A:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
29
PsiBlast_CBE
84.95
62%
-62
- C7 -
3T05
1
KPYK_STAAR
B:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
A
-
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
P
T
G
-
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
105
HHSearch
84.81
62%
-62
- C7 -
3T05
1
KPYK_STAAR
A:
[22-604]
M
R
K
T
K
I
V
C
T
I
G
P
A
S
E
S
E
E
M
I
E
K
L
I
N
A
G
M
N
V
A
R
L
N
F
S
H
G
S
H
E
E
H
K
G
R
I
D
T
I
R
K
V
A
K
R
------
L
-
D
K
I
V
A
I
L
L
D
T
K
G
P
E
I
R
T
H
N
M
K
D
G
I
---
I
E
L
E
R
G
N
E
V
I
V
S
M
N
E
-
V
-
E
G
T
P
E
K
--
F
S
V
T
Y
E
N
L
I
N
D
V
Q
V
G
S
Y
I
L
L
D
D
G
L
I
E
L
Q
V
K
D
I
D
H
A
K
K
E
V
K
C
D
I
L
N
S
G
E
L
K
N
K
K
G
V
N
L
P
G
V
R
V
S
L
P
G
I
T
E
K
D
A
E
D
I
-
R
F
G
I
K
E
N
V
D
F
I
A
A
S
F
V
R
R
P
S
D
V
L
E
I
R
E
I
L
E
E
Q
K
-
A
N
I
S
V
F
P
K
I
E
N
Q
E
G
I
D
N
I
E
E
I
L
E
V
S
D
G
L
M
V
A
R
G
D
M
G
V
E
I
P
P
E
K
V
P
M
V
Q
K
D
L
I
R
Q
C
N
K
L
G
K
P
V
I
T
A
T
Q
M
L
D
S
M
Q
R
N
P
R
A
T
R
A
E
A
S
D
V
A
N
A
I
Y
D
G
T
D
A
V
M
L
S
G
E
T
A
A
G
L
Y
P
E
E
A
V
K
T
M
R
N
I
A
V
S
A
E
A
A
Q
D
Y
K
K
L
L
S
D
--
R
T
K
--
L
V
E
T
S
L
V
N
A
I
G
I
S
V
A
H
T
A
L
N
L
N
V
K
A
I
V
A
A
T
E
S
G
S
T
A
R
T
I
S
K
Y
R
P
H
S
D
I
I
A
V
T
P
S
E
E
T
A
R
Q
C
S
I
V
W
G
V
Q
P
----
V
V
K
K
G
R
K
S
T
D
A
L
L
N
N
A
V
A
T
A
V
E
----
T
G
R
V
T
N
G
D
L
I
I
I
T
A
G
V
-
P
T
G
E
T
G
T
T
N
M
M
K
I
H
L
V
G
D
E
I
A
N
G
Q
G
I
G
R
G
S
V
V
G
T
T
L
V
A
E
T
V
K
D
L
E
G
K
D
L
S
D
K
V
I
V
T
N
S
I
D
E
T
F
V
P
Y
V
E
K
A
L
G
L
I
T
E
E
N
G
I
T
S
P
S
A
I
V
G
L
E
K
G
I
P
T
V
V
G
V
E
K
A
V
K
N
I
S
N
N
V
L
V
T
I
D
A
A
Q
G
K
I
F
E
G
Y
A
N
--
34
PsiBlast_CBE
65.84
52%
8
- C7 -
4YNG
1
KPYK1_ECOLI
C:
[1-470]
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
------
T
-
G
K
T
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
N
D
--
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
S
V
-
I
G
N
S
E
M
--
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
G
N
K
--
V
I
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
A
H
G
G
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
N
S
R
--
L
E
F
--
N
-----
R
K
L
R
I
T
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
----
Q
L
V
K
E
I
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
----
S
G
L
A
H
K
G
D
V
V
V
M
V
S
G
A
-
L
V
-
P
S
G
T
T
N
T
A
S
V
H
V
L
-----------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
65.69
52%
5
- C7 -
4YNG
2
KPYK1_ECOLI
B:
[1-470]
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
------
T
-
G
K
T
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
N
D
--
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
S
V
-
I
G
N
S
E
M
--
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
G
N
K
--
V
I
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
A
H
G
G
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
N
S
R
--
L
E
----------
K
L
R
I
T
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
----
Q
L
V
K
E
I
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
----
S
G
L
A
H
K
G
D
V
V
V
M
V
S
G
A
-
L
V
-
P
S
G
T
T
N
T
A
S
V
H
V
L
-----------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
65.44
52%
6
- C7 -
4YNG
1
KPYK1_ECOLI
G:
[1-470]
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
------
T
-
G
K
T
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
N
D--
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
S
V
-
I
G
N
S
E
M
--
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
G
N
K
--
V
I
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
A
H
G
G
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
N
S
R
--
L
E
F
-----------
R
I
T
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
----
Q
L
V
K
E
I
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
----
S
G
L
A
H
K
G
D
V
V
V
M
V
S
G
A
-
L
V
-
P
S
G
T
T
N
T
A
S
V
H
V
L
-----------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
65.33
52%
5
- C7 -
4YNG
2
KPYK1_ECOLI
D:
[1-470]
M
K
K
T
K
I
V
C
T
I
G
P
K
T
E
S
E
E
M
L
A
K
M
L
D
A
G
M
N
V
M
R
L
N
F
S
H
G
D
Y
A
E
H
G
Q
R
I
Q
N
L
R
N
V
M
S
K
------
T
-
G
K
T
A
A
I
L
L
D
T
K
G
P
E
I
R
T
M
K
L
E
G
G
N
D
--
V
S
L
K
A
G
Q
T
F
T
F
T
T
D
K
S
V
-
I
G
N
S
E
M
--
V
A
V
T
Y
E
G
F
T
T
D
L
S
V
G
N
T
V
L
V
D
D
G
L
I
G
M
E
V
T
A
I
E
G
N
K
--
V
I
C
K
V
L
N
N
G
D
L
G
E
N
K
G
V
N
L
P
G
V
S
I
A
L
P
A
L
A
E
K
D
K
Q
D
L
-
I
F
G
C
E
Q
G
V
D
F
V
A
A
S
F
I
R
K
R
S
D
V
I
E
I
R
E
H
L
K
A
H
G
G
E
N
I
H
I
I
S
K
I
E
N
Q
E
G
L
N
N
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
V
E
I
P
V
E
E
V
I
F
A
Q
K
M
M
I
E
K
C
I
R
A
R
K
V
V
I
T
A
T
Q
M
L
D
S
M
I
K
N
P
R
P
T
R
A
E
A
G
D
V
A
N
A
I
L
D
G
T
D
A
V
M
L
S
G
E
S
A
K
G
K
Y
P
L
E
A
V
S
I
M
A
T
I
C
E
R
T
D
R
V
M
N
S
R
--
L
-----------
K
L
R
I
T
E
A
V
C
R
G
A
V
E
T
A
E
K
L
D
A
P
L
I
V
V
A
T
Q
G
G
K
S
A
R
A
V
R
K
Y
F
P
D
A
T
I
L
A
L
T
T
N
E
K
T
A
H
Q
L
V
L
S
K
G
V
V
P
----
Q
L
V
K
E
I
T
S
T
D
D
F
Y
R
L
G
K
E
L
A
L
Q
----
S
G
L
A
H
K
G
D
V
V
V
M
V
S
G
A
-
L
V
-
P
S
G
T
T
N
T
A
S
V
H
V
L
-----------------------------------------------------------------------------------------------------------------
107
HHSearch
65.22
46%
-2
- C7 -
3GG8
2
?
A:
[35-509]
A
H
R
T
R
I
V
C
T
M
G
P
A
C
W
N
V
D
T
L
V
K
M
I
D
A
G
M
N
V
C
R
L
N
F
S
H
G
D
H
E
T
H
A
R
T
V
Q
N
I
Q
E
A
M
K
Q
------
R
P
E
A
R
L
A
I
L
L
D
T
K
G
P
E
I
R
T
G
F
----
P
---
I
T
L
Q
Q
G
A
T
L
K
I
V
T
D
Y
-
N
L
I
G
D
E
T
T
--
I
A
C
S
Y
G
A
L
P
Q
S
V
K
P
G
N
T
I
L
I
A
D
G
S
L
S
V
K
V
V
E
V
G
S
--
D
Y
V
I
T
Q
A
Q
N
T
A
T
I
G
E
R
K
N
M
N
L
P
N
V
K
V
Q
L
P
V
I
G
E
K
D
K
H
D
I
L
N
F
G
I
P
M
G
C
N
F
I
A
A
S
F
V
Q
S
A
D
D
V
R
Y
I
R
G
L
L
G
P
R
G
-
R
H
I
R
I
I
P
K
I
E
N
V
E
G
L
V
N
F
D
E
I
L
A
E
A
D
G
I
M
I
A
R
G
D
L
G
M
E
I
P
P
E
K
V
F
L
A
Q
K
M
M
I
A
K
C
N
V
V
G
K
P
V
I
T
A
T
Q
M
L
E
S
M
I
K
N
P
R
P
T
R
A
E
A
A
D
V
A
N
A
V
L
D
G
T
D
C
V
M
L
S
G
E
T
A
N
G
E
F
P
V
I
T
V
E
T
M
A
R
I
C
Y
E
A
E
T
C
V
D
Y
P
A
L
Y
R
A
--
M
C
L
A
V
P
P
P
I
S
T
Q
E
A
V
A
R
A
A
V
E
T
A
E
C
V
N
A
A
I
I
L
A
L
T
E
T
G
Q
T
A
R
L
I
A
K
Y
R
P
M
Q
P
I
L
A
L
S
A
S
E
S
T
I
K
H
L
Q
V
I
R
G
V
T
T
----
M
Q
V
P
S
--
G
T
D
H
V
I
R
N
A
I
V
V
A
K
E
----
R
E
L
V
T
E
G
E
S
I
V
A
V
H
G
M
-------
S
S
N
L
L
K
V
L
T
------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
60.62
45%
33
- C7 -
3N25
43
KPYM_RABIT
H:
[43-527]
-
R
N
T
G
I
I
C
T
I
G
P
A
S
R
S
V
E
T
L
K
E
M
I
K
S
G
M
N
V
A
R
M
N
F
S
H
G
T
H
E
Y
H
A
E
T
I
K
N
V
R
T
A
T
E
S
FASDPI
L
-
Y
R
P
V
A
V
A
L
D
T
K
G
P
E
I
R
T
G
L
I
K
G
S
G
TAE
V
E
L
K
K
G
A
T
L
K
I
T
L
D
N
A
Y
-
M
E
K
C
D
E
NI
L
W
L
D
Y
K
N
I
C
K
V
V
D
V
G
S
K
V
Y
V
D
D
G
L
I
S
L
Q
V
K
Q
--
K
G
-
D
F
L
V
T
E
V
E
N
G
G
F
L
G
S
K
K
G
V
N
L
P
G
A
A
V
D
L
P
A
V
S
E
K
D
I
Q
D
L
-
K
F
G
V
E
Q
D
V
D
M
V
F
A
S
F
I
R
K
A
A
D
V
H
E
V
R
K
I
L
G
E
-
K
G
K
N
I
K
I
I
S
K
I
E
N
H
E
G
V
R
R
F
D
E
I
L
E
A
S
D
G
I
M
V
A
R
G
D
L
G
I
E
I
P
A
E
K
V
F
L
A
Q
K
M
I
I
G
R
C
N
R
A
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
I
K
K
P
R
P
T
R
A
E
G
S
D
V
A
N
A
V
L
D
G
A
D
C
I
M
L
S
G
E
T
A
K
G
D
Y
P
L
E
A
V
R
M
Q
H
L
I
A
R
E
A
E
A
A
M
F
H
R
K
L
F
E
E
LA
R
A
S
--
S
Q
S
T
D
L
M
E
A
M
A
M
G
S
V
E
A
S
Y
K
C
L
A
A
A
L
I
V
L
T
E
S
G
R
S
A
H
Q
V
A
R
Y
R
P
R
A
P
I
I
A
V
T
R
N
H
Q
T
A
R
Q
A
H
L
Y
R
G
I
F
P
VVCK
D
P
V
Q
E
A
W
A
E
D
V
D
L
R
--
V
N
L
A
M
N
VGKA
R
G
F
F
K
K
G
D
V
V
I
V
L
T
G
W
-
R
P
-
G
S
G
F
T
N
T
M
R
V
--------------------------------------------------------------------------------------------------------------------