@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30060: (2016-07-19 )
MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAISGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGRMFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAVIIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRDVAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPDINEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPFRQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIHGYTGGYNITSALVTGRLAGLNAGQYARS
Atome Classification :
(20 SA)
.........10........20........30........40........50.....-....60.......------..70........80........90........100..-----------------...-----..110.......120.......130.....--..140-......-..150-...--......160.......170----.........180.......190.......200...--....-.210-....-.....-220.......230.......240.......250.......260--..-------.....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370..----.....380.......390...--......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
Q
Y
D
V
I
V
IGGG
P
S
G
L
M
A
A
I
AAGEQG
A
G
V
L
L
IDKGNKLG
R
K
L
A
ISGGGRC-NVTNR-L
P
V
E
E
-
I
I
K
HIPG------N
G
R
F
L
Y
S
A
F
S
EFN
N
E
D
I
I
K
F
F
E
NLG
I
Q
L
KEEDHGRMF-----------------PV
T
-----
D
K
A
Q
S
V
V
D
A
L
L
N
R
L
K
Q
L
R
V
T
I
RT
N
E
K
I
K
S
V
--
L
YED--G
Q
A
A
G
I
-VTN---NG
E
--
M
I
H
S
Q
A
V
I
I
A
VGGKSVP------HTGSTGDG
Y
E
W
A
E
AAGH
T
I
T
E
LFPTEVPVTS-GEP--
F
I
K
Q
-KT---LQGL-
S
L
R
D
V
-
A
V
S
V
L
NKKGK
P
I
I
T
H
K
M
D
M
L
F
T
HFGLS
G
P
A
I
L
R
C
S
Q
F
V
V
K
E
L
K
--KQ-------PQV
P
I
R
I
D
LYPDI
N
E
E
T
L
F
Q
K
M
Y
K
E
L
K
E
A
P
K
K
T
I
K
N
V
L
K
P
W
M
QER
Y
L
L
F
L
L
EKNGISPNV
S
F
S
EL
P
K
D
P
F
R
Q
F
V
R
D
C
K
Q
F
T
V
LAN
G
T
L
S
L
D
K
A
F
VTGGG
V
S
V
K
EI
D
P
K
K
M
----
A
S
K
K
M
E
G
L
Y
F
C
G
E
I
L
D--IHG--YTGG
Y
N
I
T
S
A
L
V
T
G
R
LAGLNAGQYARS
102
HHSearch
74.95
70%
-59
* C2 *
2I0Z
2
?
A:
[25-444]
-
M
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
K
L
A
I
S
G
G
G
R
C
-
N
V
T
N
R
-
L
P
L
D
E
-
I
V
K
H
I
P
G
------
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
D
H
G
R
M
F
-----------------
P
V
S
-----
N
K
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
G
V
K
I
R
T
N
T
P
V
E
T
I
--
E
Y
E
N
--
G
Q
T
K
A
V
-
I
L
Q
---
T
G
E
--
V
L
E
T
N
H
V
V
I
A
V
G
G
K
S
V
P
------
Q
T
G
S
T
G
D
G
Y
A
W
A
E
K
A
G
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
-
N
E
P
--
F
I
R
D
-
R
S
---
L
Q
G
L
-
A
L
R
D
I
N
L
S
V
L
N
-----
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
P
A
A
L
R
C
S
Q
F
V
V
K
A
L
K
--
K
F
KT-----
N
T
I
Q
M
S
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
K
G
I
K
N
V
L
K
G
Y
V
P
E
R
Y
F
L
F
L
L
E
K
N
E
I
D
G
S
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
K
E
I
N
P
K
E
M
----
S
S
K
F
T
N
G
L
Y
F
C
G
E
V
L
D
--
I
H
G
--
Y
T
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
-
123
Fugue
74.91
69%
-55
- C2 -
2I0Z
2
?
A:
[25-444]
-
M
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
K
L
A
I
S
G
G
G
R
C
-
N
V
T
N
R
-
L
P
L
D
E
-
I
V
K
H
I
P
G
------
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
D
H
G
R
M
F
-----------------
P
V
S
-----
N
K
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
G
V
K
I
R
T
N
T
P
V
E
T
I
--
E
Y
E
N
--
G
Q
T
K
A
V
-
I
L
Q
---
T
G
E
--
V
L
E
T
N
H
V
V
I
A
V
G
G
K
S
V
P
------
Q
T
G
S
T
G
D
G
Y
A
W
A
E
K
A
G
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
-
N
E
P
--
F
I
R
D
-
R
S
---
L
Q
G
L
-
A
L
R
D
I
-
N
L
S
V
----
L
N
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
P
A
A
L
R
C
S
Q
F
V
V
K
A
L
K
--
K
F
KT-----
N
T
I
Q
M
S
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
K
G
I
K
N
V
L
K
G
Y
V
P
E
R
Y
F
L
F
L
L
E
K
N
E
I
D
G
S
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
K
E
I
N
P
K
E
M
----
S
S
K
F
T
N
G
L
Y
F
C
G
E
V
L
D
--
I
H
G
--
Y
T
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
-
1
PsiBlast_PDB
74.85
70%
-56
- C2 -
2I0Z
2
?
A:
[26-444]
--
H
Y
D
V
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
N
V
L
L
L
D
K
G
N
K
L
G
R
K
L
A
I
S
G
G
G
R
C
-
N
V
T
N
R
-
L
P
L
D
E
-
I
V
K
H
I
P
G
------
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
D
H
G
R
M
F
-----------------
P
V
S
-----
N
K
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
G
V
K
I
R
T
N
T
P
V
E
T
I
--
E
Y
E
N
--
G
Q
T
K
A
V
-
I
L
Q
---
T
G
E
--
V
L
E
T
N
H
V
V
I
A
V
G
G
K
S
V
P
------
Q
T
G
S
T
G
D
G
Y
A
W
A
E
K
A
G
H
T
I
T
E
L
F
P
T
E
V
P
I
L
S
-
N
E
P
--
F
I
R
D
-
R
S
---
L
Q
G
L
-
A
L
R
D
I
-
N
L
S
V
L
N
----
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
G
P
A
A
L
R
C
S
Q
F
V
V
K
A
L
K
K
F
K
T
-------
N
T
I
Q
M
S
I
D
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
K
G
I
K
N
V
L
K
G
Y
V
P
E
R
Y
F
L
F
L
L
E
K
N
E
I
D
G
S
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
K
E
I
N
P
K
E
M
----
S
S
K
F
T
N
G
L
Y
F
C
G
E
V
L
D
--
I
H
G
--
Y
T
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
-
21
PsiBlast_CBE
65.37
44%
-104
- C2 -
4CNK
13
?
B:
[1-386]
M
N
H
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
C
-
N
V
T
N
N
-
G
N
L
D
D
-
L
M
A
G
I
P
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
D
H
G
R
V
F
-----------------
P
V
T
-----
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
N
T
E
I
V
S
V
--
K
K
T
D
----
E
L
F
T
-
V
R
S
---
S
D
Q
--
A
W
T
C
Q
K
L
I
V
T
T
G
G
K
S
Y
P
------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
P
-----
H
-
K
A
---
L
Q
G
I
-
S
L
D
D
V
-
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
A
L
R
L
S
S
F
V
--------
K
-------
G
G
E
T
I
Y
L
D
V
L
P
Q
M
S
Q
----
Q
D
L
A
D
F
L
E
E
H
R
E
K
S
L
K
N
C
L
K
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
---
F
P
E
-
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
K
E
I
N
P
K
T
L
----
E
S
K
L
V
P
G
L
H
F
A
G
E
V
L
D
--
I
N
A
--
H
T
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
---------
3
PsiBlast_PDB
65.36
44%
-103
- C2 -
4CNK
11
?
A:
[1-386]
M
N
H
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
C
-
N
V
T
N
N
-
G
N
L
D
D
-
L
M
A
G
I
P
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
D
H
G
R
V
F
-----------------
P
V
T
-----
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
N
T
E
I
V
S
V
--
K
K
T
D
----
E
L
F
T
-
V
R
S
---
S
D
Q
--
A
W
T
C
Q
K
L
I
V
T
T
G
G
K
S
Y
P
------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
P
-----
H
-
K
A
---
L
Q
G
I
-
S
L
D
D
V
-
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
A
L
R
L
S
S
F
V
--------
K
-------
G
G
E
T
I
Y
L
D
V
L
P
Q
M
S
Q
----
Q
D
L
A
D
F
L
E
E
H
R
E
K
S
L
K
N
C
L
K
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
---
F
P
E
-
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
K
E
I
N
P
K
T
L
----
E
S
K
L
V
P
G
L
H
F
A
G
E
V
L
D
--
I
N
A
--
H
T
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
---------
23
PsiBlast_CBE
65.10
44%
-103
- C2 -
4CNJ
1
?
C:
[1-386]
M
N
H
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
C
-
N
V
T
N
N
-
G
N
L
D
D
-
L
M
A
G
I
P
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
D
H
G
R
V
F
-----------------
P
V
T
-----
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
N
T
E
I
V
S
V
--
K
K
T
D
----
E
L
F
T
-
V
R
S
---
S
D
Q
--
A
W
T
C
Q
K
L
I
V
T
T
G
G
K
S
Y
P
------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
P
-----
H
-
K
A
---
L
Q
G
I
-
S
L
D
D
V
-
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
A
L
R
L
S
S
F
V
--------
K
-------
G
G
E
T
I
Y
L
D
V
L
P
Q
M
S
Q
----
Q
D
L
A
D
F
L
E
E
H
R
E
K
S
L
K
N
C
L
K
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
---
F
P
E
-
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
K
E
I
N
P
K
T
L
----
E
S
K
L
V
P
G
L
H
F
A
G
E
V
L
D
--
I
N
A
--
H
T
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
---------
22
PsiBlast_CBE
65.10
44%
-104
- C2 -
4CNJ
1
?
D:
[1-386]
M
N
H
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
C
-
N
V
T
N
N
-
G
N
L
D
D
-
L
M
A
G
I
P
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
D
H
G
R
V
F
-----------------
P
V
T
-----
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
N
T
E
I
V
S
V
--
K
K
T
D
----
E
L
F
T
-
V
R
S
---
S
D
Q
--
A
W
T
C
Q
K
L
I
V
T
T
G
G
K
S
Y
P
------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
P
-----
H
-
K
A
---
L
Q
G
I
-
S
L
D
D
V
-
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
A
L
R
L
S
S
F
V
--------
K
-------
G
G
E
T
I
Y
L
D
V
L
P
Q
M
S
Q
----
Q
D
L
A
D
F
L
E
E
H
R
E
K
S
L
K
N
C
L
K
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
---
F
P
E
-
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
K
E
I
N
P
K
T
L
----
E
S
K
L
V
P
G
L
H
F
A
G
E
V
L
D
--
I
N
A
--
H
T
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
---------
2
PsiBlast_PDB
64.56
44%
-104
- C2 -
4CNJ
1
?
A:
[1-386]
M
N
H
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
C
-
N
V
T
N
N
-
G
N
L
D
D
-
L
M
A
G
I
P
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
D
H
G
R
V
F
-----------------
P
V
T
-----
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
N
T
E
I
V
S
V
--
K
K
T
D
----
E
L
F
T
-
V
R
S
---
S
D
Q
--
A
W
T
C
Q
K
L
I
V
T
T
G
G
K
S
Y
P
------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
P
-----
H
-
K
A
---
L
Q
G
I
-
S
L
D
D
V
-
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
A
L
R
L
S
S
F
V
--------
K
-------
G
G
E
T
I
Y
L
D
V
L
P
Q
M
S
Q
----
Q
D
L
A
D
F
L
E
E
H
R
E
K
S
L
K
N
C
L
K
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
---
F
P
E
-
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
K
E
I
N
P
K
T
L
----
E
S
K
L
V
P
G
L
H
F
A
G
E
V
L
D
--
I
N
A
--
H
T
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
---------
24
PsiBlast_CBE
64.47
44%
-104
- C2 -
4CNJ
1
?
B:
[1-386]
M
N
H
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
C
-
N
V
T
N
N
-
G
N
L
D
D
-
L
M
A
G
I
P
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
D
H
G
R
V
F
-----------------
P
V
T
-----
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
N
T
E
I
V
S
V
--
K
K
T
D
----
E
L
F
T
-
V
R
S
---
S
D
Q
--
A
W
T
C
Q
K
L
I
V
T
T
G
G
K
S
Y
P
------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
P
-----
H
-
K
A
---
L
Q
G
I
-
S
L
D
D
V
-
T
L
S
Y
----
G
K
H
I
I
T
H
--
D
L
L
F
T
H
F
G
L
S
G
P
A
A
L
R
L
S
S
F
V
--------
K
-------
G
G
E
T
I
Y
L
D
V
L
P
Q
M
S
Q
----
Q
D
L
A
D
F
L
E
E
H
R
E
K
S
L
K
N
C
L
K
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
---
F
P
E
-
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
K
E
I
N
P
K
T
L
----
E
S
K
L
V
P
G
L
H
F
A
G
E
V
L
D
--
I
N
A
--
H
T
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
---------
101
HHSearch
64.43
44%
-103
- C2 -
4CNK
11
?
A:
[1-391]
M
N
H
F
D
T
I
I
I
G
G
G
P
A
G
M
M
A
T
I
S
S
S
F
Y
G
Q
K
T
L
L
L
E
K
N
K
R
L
G
K
K
L
A
G
T
G
G
G
R
C
-
N
V
T
N
N
-
G
N
L
D
D
-
L
M
A
G
I
P
G
------
N
G
R
F
L
Y
S
V
F
S
Q
F
D
N
H
D
I
I
N
F
F
T
E
N
G
V
K
L
K
V
E
D
H
G
R
V
F
-----------------
P
V
T
-----
D
K
S
R
T
I
I
E
A
L
E
K
K
I
A
E
L
G
G
T
V
I
T
N
T
E
I
V
S
V
--
K
K
T
D
--
E
L
F
-
T
V
-
R
S
S
---
D
-
Q
--
A
W
T
C
Q
K
L
I
V
T
T
G
G
K
S
Y
P
------
S
T
G
S
T
G
F
G
H
D
I
A
R
H
F
K
H
T
V
T
D
L
E
A
A
E
S
P
L
L
T
-
D
F
P
--
H
K
A
-------
L
Q
G
I
-
S
L
D
D
V
-
T
L
S
Y
G
------
K
H
I
I
T
H
D
L
L
F
T
H
F
G
L
S
G
P
A
A
L
R
L
S
S
F
V
K
G
G
E
---------------
T
I
Y
L
D
V
L
P
Q
M
S
Q
Q
D
L
A
D
F
L
E
E
H
----
R
E
K
S
L
K
N
C
L
K
I
L
L
P
E
R
I
A
D
F
F
T
Q
P
F
P
E
----
K
V
K
Q
L
N
L
S
E
K
E
A
L
I
K
Q
I
K
E
L
P
I
S
V
T
G
K
M
S
L
A
K
S
F
V
T
K
G
G
V
S
L
K
E
I
N
P
K
T
L
----
E
S
K
L
V
P
G
L
H
F
A
G
E
V
L
D
--
I
N
A
--
H
T
G
G
F
N
I
T
S
A
L
C
T
G
W
V
A
G
S
L
H
Y
D
----
4
PsiBlast_PDB
51.81
30%
-46
- C2 -
2GQF
2
Y933_HAEIN
A:
[8-397]
------
I
I
I
G
A
G
A
A
G
L
F
C
A
A
Q
L
A
K
L
G
K
S
V
T
V
F
D
N
G
K
K
I
G
R
K
I
L
M
S
G
G
G
F
C
-
N
F
T
N
--
L
E
V
T
P
-
A
-
H
Y
L
S
Q
------
N
P
H
F
V
K
S
A
L
A
R
Y
T
N
W
D
F
I
S
L
V
A
E
Q
G
I
T
Y
H
E
K
E
L
G
Q
L
F
------------------
C
D
-----
E
G
A
E
Q
I
V
E
M
L
K
S
E
C
D
K
Y
G
A
K
I
L
L
R
S
E
V
S
Q
V
E
R
I
Q
N
D
--
E
K
V
R
F
V
-
L
Q
V
---
N
S
T
--
Q
W
Q
C
K
N
L
I
V
A
T
G
G
L
S
M
P
------
G
L
G
A
T
P
F
G
Y
Q
I
A
E
Q
F
G
------
I
P
V
I
P
P
R
A
S
-
L
V
P
--
F
T
Y
R
-
E
T
DKF
L
T
A
L
-
S
G
I
S
L
-
P
V
T
I
T
A
L
C
G
K
S
F
Y
N
Q
---
L
L
F
T
H
R
G
I
S
G
P
A
V
L
Q
I
S
N
Y
--------
W
Q
-------
P
T
E
S
V
E
I
D
L
L
P
N
H
N
V
E
---
E
E
I
N
Q
A
K
Q
S
S
P
K
Q
M
L
K
T
I
L
V
R
L
L
P
K
K
L
V
E
L
W
I
E
Q
-
G
I
V
Q
D
E
V
I
A
N
I
S
K
V
R
V
K
N
L
V
D
F
I
H
H
W
E
F
T
P
N
G
T
E
G
Y
R
T
A
E
V
T
M
G
G
V
D
T
K
V
I
S
S
K
T
M
----
E
S
N
Q
V
S
G
L
Y
F
I
G
E
V
L
D
--
V
T
G
--
W
L
G
G
Y
N
F
Q
W
A
W
S
S
A
Y
A
C
A
L
S
-------
109
HHSearch
51.59
31%
-17
- C2 -
2GQF
2
Y933_HAEIN
A:
[2-401]
S
Q
Y
S
E
N
I
I
I
G
A
G
A
A
G
L
F
C
A
A
Q
L
A
K
L
G
K
S
V
T
V
F
D
N
G
K
K
I
G
R
K
I
L
M
S
G
G
G
F
C
-
N
F
T
N
L
-
E
V
T
P
A
----
H
Y
L
S
Q-----
N
P
H
F
V
K
S
A
L
A
R
Y
T
N
W
D
F
I
S
L
V
A
E
Q
G
I
T
Y
H
E
K
E
L
G
Q
L
F
-----------------
C
D
------
E
G
A
E
Q
I
V
E
M
L
K
S
E
C
D
K
Y
G
A
K
I
L
L
R
S
E
V
S
Q
V
--
E
R
I
Q
ND
E
K
V
R
F
V
-
L
Q
V
---
N
S
T
--
Q
W
Q
C
K
N
L
I
V
A
T
G
G
L
S
M
P
------
G
L
G
A
T
P
F
G
Y
Q
I
A
E
Q
F
G
I
P
V
I
P
P
R
A
S
L
V
P
F
T
Y
-
R
E
T
DK
F
L
T
---
A
---
L
S
G
I
-
S
L
-
P
--
V
T
I
T
A
L
C
-
G
K
S
F
Y
N
Q
L
---
L
F
T
H
R
G
I
S
G
P
A
V
L
Q
I
S
N
Y
W
Q
P
T
---------------
E
S
V
E
I
D
L
L
P
N
H
N
V
E
E
E
I
N
Q
A
K
Q
S
S
---
P
K
Q
M
L
K
T
I
L
V
R
L
L
P
K
K
L
V
E
L
W
I
E
Q
-
G
I
V
Q
D
E
V
I
A
N
I
S
K
V
R
V
K
N
L
V
D
F
I
H
H
W
E
F
T
P
N
G
T
E
G
Y
R
T
A
E
V
T
M
G
G
V
D
T
K
V
I
S
S
K
T
M
----
E
S
N
Q
V
S
G
L
Y
F
I
G
E
V
L
D
--
V
T
G
--
W
L
G
G
Y
N
F
Q
W
A
W
S
S
A
Y
A
C
A
L
S
I
S
R
Q
---
108
HHSearch
51.17
30%
-20
- C2 -
3V76
1
?
A:
[28-417]
---
Q
D
V
V
I
I
G
A
G
A
A
G
M
M
C
A
I
E
A
G
K
R
G
R
R
V
L
V
I
D
H
A
R
A
P
G
E
K
I
R
I
S
G
G
G
R
C
-
N
F
T
N
I
-
H
A
S
P
R
N
F
L
S
---
G
------
N
P
H
F
C
K
S
A
L
A
R
Y
R
P
Q
D
F
V
A
L
V
E
R
H
G
I
G
W
H
E
K
T
L
G
Q
L
F
-----------------
C
-
D
-----
H
S
A
K
D
I
I
R
M
L
M
A
E
M
K
E
A
G
V
Q
L
R
L
E
T
S
I
G
E
V
--
E
R
T
A
--
S
G
F
-
R
V
-
T
T
S
---
A
G
---
T
V
D
A
A
S
L
V
V
A
S
G
G
K
S
I
P
------
K
M
G
A
T
G
L
A
Y
R
I
A
E
Q
F
G
L
P
V
V
E
T
R
P
A
L
V
P
L
T
L
-
D
Q
A
--
Q
L
A
K
L
G
A
---
L
A
G
V
-
A
A
----
D
A
E
A
R
F
----
G
K
A
A
F
R
E
A
V
L
I
T
H
R
G
L
S
G
P
A
I
L
Q
I
S
S
Y
W
R
E
G
---------------
E
E
I
V
L
R
L
M
P
D
I
D
I
A
S
I
L
K
G
M
R
R
A
N
---
G
R
Q
A
V
Q
T
A
L
A
D
I
L
P
R
R
L
A
Q
F
F
A
D
E
A
K
L
T
-
G
R
M
L
A
D
L
S
D
K
T
I
D
A
L
A
S
S
I
Q
V
W
A
V
K
P
A
G
S
E
G
Y
R
T
A
E
V
T
L
G
G
V
D
T
R
A
L
D
S
R
T
M
----
Q
A
K
E
V
P
G
L
Y
F
V
G
E
C
V
D
--
V
T
G
--
W
L
G
G
Y
N
F
Q
W
A
W
A
S
G
F
V
A
G
Q
D
V
------
5
PsiBlast_PDB
46.05
29%
-17
- C2 -
3V76
1
?
A:
[46-414]
---------------------
A
G
K
R
G
R
R
V
L
V
I
D
H
A
R
A
P
G
E
K
I
R
I
S
G
G
G
R
C
-
N
F
T
N
I
-
H
A
S
P
R
---
N
F
L
S
G
------
N
P
H
F
C
K
S
A
L
A
R
Y
R
P
Q
D
F
V
A
L
V
E
R
H
G
I
G
W
H
E
K
T
L
G
Q
L
F
------------------
C
D
-----
H
S
A
K
D
I
I
R
M
L
M
A
E
M
K
E
A
G
V
Q
L
R
L
E
T
S
I
G
E
V
-----
E
--
R
T
A
S
G
F
R
V
T
T
---
S
A
G
--
T
V
D
A
A
S
L
V
V
A
S
G
G
K
S
I
P
------
K
M
G
A
T
G
L
A
Y
R
I
A
E
Q
F
G
L
P
V
V
E
T
R
P
A
L
V
P
L
T
--------
L
D
Q
-
A
Q
---
L
A
K
L
G
A
L
A
G
V
-
A
A
D
A
E
A
R
F
G
K
A
A
F
--
R
E
A
V
L
I
T
H
R
G
L
S
G
P
A
I
L
Q
I
S
S
Y
----
W
R
--
E
G
-------
E
E
I
V
L
R
--
L
M
P
D
I
D
I
A
S
I
L
K
G
M
R
---
R
A
N
G
R
Q
A
V
Q
T
A
L
A
D
I
L
P
R
R
L
A
Q
F
F
A
D
E
A
K
L
T
G
R
-
M
L
A
D
L
S
D
K
T
I
D
A
L
A
S
S
I
Q
V
W
A
V
K
P
A
G
S
E
G
Y
R
T
A
E
V
T
L
G
G
V
D
T
R
A
L
D
S
R
T
M
----
Q
A
K
E
V
P
G
L
Y
F
V
G
E
C
V
D
--
V
T
G
--
W
L
G
G
Y
N
F
Q
W
A
W
A
S
G
F
V
A
G
---------
32
PsiBlast_CBE
41.70
53%
-206
- C3 -
2Q7V
2
?
B:
[9-40]
---
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
T
L
I
L
E
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
41.51
53%
-208
- C3 -
2Q7V
2
?
A:
[9-40]
---
Y
D
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
T
L
I
L
E
K
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
41.16
47%
-235
- C3 -
2BXR
1
AOFA_HUMAN
A:
[14-57]
---
F
D
V
V
V
I
G
G
G
I
S
G
L
S
A
A
K
L
L
T
E
Y
G
V
S
V
L
V
L
E
A
R
D
R
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
41.03
47%
-237
- C3 -
2BXR
1
AOFA_HUMAN
B:
[14-57]
---
F
D
V
V
V
I
G
G
G
I
S
G
L
S
A
A
K
L
L
T
E
Y
G
V
S
V
L
V
L
E
A
R
D
R
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
40.55
47%
-207
- C3 -
2Z5Y
1
AOFA_HUMAN
A:
[3-38]
---
F
D
V
V
V
I
G
G
G
I
S
G
L
S
A
A
K
L
L
T
E
Y
G
V
S
V
L
V
L
E
A
R
D
R
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
40.44
18%
0
- C- -
2H88
4
SDHA_CHICK
A:
[17-433]
-
H
E
F
D
A
V
V
V
G
A
G
G
A
G
L
R
A
A
F
G
L
S
E
A
G
F
N
T
A
C
V
T
K
L
F
P
T
R
S
H
T
V
A
A
Q
G
G
I
N
A
A
L
G
N
M
E
D
D
N
W
R
W
H
F
Y
D
T
V
K
G
S
DWLG
D
Q
D
A
I
-
H
Y
M
T
-
E
Q
A
P
A
A
V
I
E
L
E
N
Y
G
M
P
F
S
R
T
E
E
G
K
I
Y
Q
R
A
F
G
GQSLQFGKGGQA
H
R
C
C
C
VAD
R
T
G
H
S
L
L
H
T
L
Y
G
R
S
L
R
Y
D
T
S
Y
F
V
E
Y
F
A
L
D
L
--
L
M
E
N
--
G
E
C
R
G
V
-
I
A
L
CIE
D
G
T
I
H
R
F
R
A
K
N
T
V
I
A
T
G
G
Y
G
R
T
YFSCTS
A
H
T
S
T
G
D
G
T
A
M
V
T
R
A
G
L
P
C
Q
D
L
E
F
V
Q
F
H
P
T
G
I
Y
G
A
--
G
C
L
I
------
T
E
G
C
-
R
G
-
E
G
-
G
I
L
I
N
S
Q
-
G
E
R
F
M
E
R
Y
A
P
V
A
K
---
D
L
A
S
R
D
V
V
S
R
S
--
M
T
I
E
I
R
--
E
G
RGCGPEK
D
H
V
--
Y
L
------------
Q
L
H
H
-----
L
P
P
Q
Q
L
A
T
R
L
P
-----
G
I
S
E
T
A
M
I
F
A
G
V
D
V
-------------------
T
K
E
P
I
P
V
L
---
P
--
T
V
H
Y
N
M
G
G
I
P
T
N
Y
K
G
Q
V
I
T
H
V
NG
E
D
K
V
V
P
G
L
Y
A
C
G
E
A
A
S
AS
V
H
G
AN
R
L
G
A
N
S
L
L
D
L
V
V
F
G
R
A
C
A
L
T
I
A
E
T
C
K
-