@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu31060: (2016-07-21 )
MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIKAIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKADMDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWKIAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNKDVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVFFHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKVEKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTVETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPWGGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
Q
T
L
F
IDGEWI
S
A
E
K
E
Q
I
R
S
I
INPF
N
Q
E
E
I
A
T
V
SEGG
R
E
D
A
I
K
A
I
A
A
A
R
R
AFDKGEWSSLSGLERG
K
I
V
L
K
I
A
E
L
I
R
R
D
L
E
E
L
A
E
L
E
SLDTGK
T
L
E
E
SKA
D
M
D
D
I
A
N
V
F
Q
Y
YAGLADKDGG
E
I
ISSPIPDS
E
S
K
I
I
R
E
P
I
GVCGQITPWNYP
L
L
QAS
W
K
I
A
P
A
LAAG
N
T
I
V
MKPSEITP
L
T
T
I
K
V
F
K
L
M
E
E
AGVPK
G
V
A
N
LVLGPGATVGDELAVNKDV
D
L
I
S
FTGG
I
E
T
G
K
K
I
M
R
AASGN
V
K
K
I
A
L
E
LGGKNP
N
I
V
F
KDAD
L
E
V
A
V
D
Q
A
L
N
A
V
F
F
HA
G
Q
V
CSAG
S
R
L
L
V
E
D
A
I
H
D
Q
F
L
A
E
L
V
K
R
A
K
RIKLGNGFHAETESG
P
L
I
S
A
E
H
R
A
K
V
E
K
Y
V
E
IGIEEGAKLETGGKRPEDPELQN
G
F
F
YEPTIFSNCN
S
D
M
R
I
V
Q
E
EVFG
P
V
L
T
V
ETFS
S
E
E
E
V
I
E
L
AND
T
I
Y
G
L
A
G
A
V
W
S
K
D
I
E
K
C
E
R
V
A
A
R
LR
M
G
T
V
W
INDF
H
P
Y
FAQAPWGGYKQSGF
G
R
E
L
G
K
I
G
L
E
E
Y
T
E
V
K
H
V
Y
RNTKP
A
A
V
NWFNS
43
PsiBlast_PDB
90.57
66%
-54
- C2 -
5DIB
5
?
A:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
L
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
55
PsiBlast_CBE
90.56
67%
-51
- C2 -
4NEA
6
?
B:
[31-519]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
32
PsiBlast_PDB
90.55
67%
-54
- C2 -
4NEA
6
?
A:
[31-519]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
63
PsiBlast_CBE
90.33
66%
-52
- C2 -
4QN2
2
?
B:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
57
PsiBlast_CBE
90.33
66%
-52
- C2 -
4QN2
2
?
H:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
42
PsiBlast_PDB
90.30
66%
-53
- C2 -
5EYU
7
?
A:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
62
PsiBlast_CBE
90.23
66%
-51
- C2 -
4QN2
1
?
C:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
35
PsiBlast_PDB
90.20
66%
-51
- C2 -
4QN2
2
?
A:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
67
PsiBlast_CBE
90.11
66%
-52
- C2 -
4ZXU
3
?
E:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
54
PsiBlast_CBE
90.05
67%
-53
- C2 -
4NEA
6
?
C:
[31-519]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
40
PsiBlast_PDB
90.03
66%
-52
- C2 -
4ZXU
4
?
A:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
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R
V
K
K
I
K
L
G
N
G
F
D
A
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T
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M
G
P
V
I
S
T
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R
N
K
I
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Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
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E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
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F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
34
PsiBlast_PDB
90.03
66%
-53
- C2 -
4QJE
6
?
B:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
64
PsiBlast_CBE
90.00
66%
-53
- C2 -
4ZXU
5
?
H:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
77
PsiBlast_CBE
89.98
66%
-55
- C2 -
4ZWL
3
?
B:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
P
L
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
44
PsiBlast_PDB
89.98
66%
-51
- C2 -
5EZ4
7
?
A:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
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D
A
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A
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A
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N
G
G
Y
F
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A
G
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A
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I
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N
S
I
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D
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F
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A
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K
I
K
L
G
N
G
F
D
A
D
T
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M
G
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N
K
I
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Y
M
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A
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A
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G
A
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A
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G
G
K
R
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R
D
D
L
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D
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L
F
F
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V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
M
L
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
72
PsiBlast_CBE
89.90
66%
-52
- C2 -
4ZWL
4
?
G:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
P
L
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
39
PsiBlast_PDB
89.89
66%
-51
- C2 -
4Q92
4
?
A:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
70
PsiBlast_CBE
89.84
66%
-52
- C2 -
4ZXU
3
?
B:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
F
M
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
36
PsiBlast_PDB
89.75
66%
-54
- C2 -
4MPY
4
?
A:
[31-519]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-
60
PsiBlast_CBE
89.73
66%
-52
- C2 -
4QN2
1
?
E:
[28-516]
L
S
Q
R
Q
Y
I
D
G
E
W
V
E
S
A
N
K
N
T
R
D
I
I
N
P
Y
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
R
R
A
F
E
S
G
E
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
T
L
E
E
S
Y
A
D
M
D
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
G
G
E
M
I
D
S
P
I
P
D
T
E
S
K
I
V
K
E
P
V
G
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
T
I
R
V
F
E
L
M
E
E
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
V
G
D
V
M
S
G
H
K
E
V
D
L
V
S
F
T
G
S
I
E
T
G
K
H
I
M
K
N
A
A
N
N
V
T
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
A
T
I
A
V
G
G
K
R
P
D
R
D
D
L
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
Y
F
A
Q
A
P
W
G
G
Y
K
Q
S
G
I
G
R
E
L
G
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
P
Q
L
V
N
W
F
S
-