@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu31300: (2016-07-22 )
MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSRALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIVTFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSASFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVAREIMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLGQPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEIVGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQKMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230....-...240.......250....-.-..260.......-270....--.--...280.--.....----...290.......300.......310...--------....320.......330...-....340.......350.......360.......370.......380.......390..-....-.400.......410.......420.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
I
L
Q
L
I
A
I
F
V
L
I
G
I
T
A
V
F
V
A
A
E
F
A
I
V
K
I
R
G
S
K
I
N
Q
L
I
ESGDS
R
A
L
A
A
H
K
I
I
S
N
L
D
E
Y
L
S
A
C
QLG
I
T
I
T
A
L
GLGWLG
E
P
T
F
E
R
F
L
H
P
L
F
T
MTGIP
E
P
F
N
H
I
V
T
F
V
V
A
F
I
I
V
T
F
L
H
V
V
M
G
ELAPK
T
V
S
I
Q
KA
E
A
V
S
L
WIAK
P
L
I
W
F
Y
KI
T
Y
P
F
I
K
ALNG
S
A
S
F
L
V
K
L
F
G
FHSVKE
H
Q
V
V
I
S
E
E
E
L
R
L
I
L
S
ESYEKGEI
N
Q
S
E
F
R
Y
V
N
K
I
F
E
F
D
N
R
V
A
R
E
IMIPRT
E
I
A
V
I
S
L
E
Q
S
L
E
-
E
A
I
H
H
I
I
N
ERYTRYPVIKDD-K-D
H
I
L
G
I
INS
K
D
M
-
F
K
-
A
Y
FL--G--QP
I
K
--
L
--
N
Q
I
M
R
----
P
V
I
R
V
I
E
SI
P
V
Q
Q
L
L
I
R
M
Q
K
ER
I
H
M
A
I
L
V
--------DEYGGTAG
L
V
T
V
E
D
I
I
E
E
I
V
-
G
E
I
R
D
EYDQDET
P
H
I
L
KKGEH
H
Y
V
MD
G
K
A
L
I
D
E
V
N
D
L
L
D
I
AIENE
E
I
D
T
I
A
G
W
L
L
T
Q
K
M
-ELKA-G
D
V
I
HAEG
C
E
F
K
I
L
DAED
H
H
I
R
F
V
E
I
KKTDF
27
HHSearch
78.82
32%
-64
- C1 -
4HG0
1
CORC_ECOLI
A:
[51-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
D
T
R
D
M
L
E
G
V
M
D
I
A
D
Q
R
V
R
D
I
M
I
P
R
S
Q
M
I
T
L
K
R
N
Q
T
L
D
-
E
C
L
D
V
I
I
E
S
A
H
S
R
F
P
V
I
S
E
D
-
K
-
D
H
I
E
G
I
L
M
A
K
D
L
-
L
P
-
F
M
R
S
--
D
A-
E
A
F
S
--
M
--
D
K
V
L
R
----
Q
A
V
V
V
P
E
S
K
R
V
D
R
M
L
K
E
F
R
S
Q
R
Y
H
M
A
I
V
I
--------
D
E
F
G
G
V
S
G
L
V
T
I
E
D
I
L
E
L
I
V
-
G
E
I
E
D
E
Y
D
E
E
D
D
I
D
F
R
Q
L
S
R
H
T
W
T
V
R
A
L
A
S
I
E
D
F
N
E
A
F
G
T
H
F
S
D
E
E
V
D
T
I
G
G
L
V
M
Q
A
F
G
H
L
P
A
R
-
G
E
T
I
D
I
D
G
Y
Q
F
K
V
A
M
A
D
S
R
R
I
I
Q
V
H
V
K
I
P
--
29
HHSearch
77.14
36%
-174
- C1 -
3OI8
4
?
A:
[2-156]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
S
A
E
D
V
L
N
L
L
R
Q
A
H
E
Q
E
V
F
D
A
D
T
L
L
R
L
E
K
V
L
D
F
S
D
L
E
V
R
D
A
M
I
T
R
S
R
M
N
V
L
K
E
N
D
S
I
E
-
R
I
T
A
Y
V
I
D
T
A
H
S
R
F
P
V
I
G
E
D
-
K
-
D
E
V
L
G
I
L
H
A
K
D
L
-
L
K
-
Y
M
F
N
--
P
--
E
Q
F
H
--
L
--
K
S
I
L
R
----
P
A
V
F
V
P
E
G
K
S
L
T
A
L
L
K
E
F
R
E
Q
R
N
H
M
A
I
V
I
--------
D
E
Y
G
G
T
S
G
L
V
T
F
E
D
I
I
E
----------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.91
35%
-174
- C1 -
3OI8
4
?
A:
[4-156]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
E
D
V
L
N
L
L
R
Q
A
H
E
Q
E
V
F
D
A
D
T
L
L
R
L
E
K
V
L
D
F
S
D
L
E
V
R
D
A
M
I
T
R
S
R
M
N
V
L
K
E
N
D
S
I
E
-
R
I
T
A
Y
V
I
D
T
A
H
S
R
F
P
V
I
G
E
D
-
K
-
D
E
V
L
G
I
L
H
A
K
D
L
-
L
K
-
Y
M
F
N
--
P
--
E
Q
F
H
--
L
--
K
S
I
L
R
----
P
A
V
F
V
P
E
G
K
S
L
T
A
L
L
K
E
F
R
E
Q
R
N
H
M
A
I
V
I
--------
D
E
Y
G
G
T
S
G
L
V
T
F
E
D
I
I
E
----------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.14
31%
-63
- C1 -
4HG0
1
CORC_ECOLI
A:
[51-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
D
T
R
D
M
L
E
G
V
M
D
I
A
D
Q
R
V
R
D
I
M
I
P
R
S
Q
M
I
T
L
K
R
N
Q
T
L
D
-
E
C
L
D
V
I
I
E
S
A
H
S
R
F
P
V
I
S
E
D
-
K
-
D
H
I
E
G
I
L
M
A
K
D
L
-
L
P
F
M
R
S
D
--
A
--
E
A
F
S
--
M
--
D
K
V
L
R
----
Q
A
V
V
V
P
E
S
K
R
V
D
R
M
L
K
E
F
R
S
Q
R
Y
H
M
A
I
V
I
--------
D
E
F
G
G
V
S
G
L
V
T
I
E
D
I
L
E
L
I
V
-
G
E
I
E
D
E
Y
D
E
E
D
D
I
D
F
R
Q
L
S
R
H
T
W
T
V
R
A
L
A
S
I
E
D
F
N
E
A
F
G
T
H
F
S
D
E
E
V
D
T
I
G
G
L
V
M
Q
A
F
G
-
H
L
P
A
R
G
E
T
I
D
I
D
G
Y
Q
F
K
V
A
M
A
D
S
R
R
I
I
Q
V
H
V
K
I
P
--
1
PsiBlast_PDB
68.33
43%
-161
- C1 -
3LV9
1
?
A:
[18-147]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
F
E
E
K
K
I
R
E
I
M
V
P
R
T
D
M
V
C
I
Y
E
S
D
S
E
E
-
K
I
L
A
I
L
K
E
E
G
V
T
R
Y
P
V
C
R
K
N
-
K
-
D
D
I
L
G
F
V
H
I
R
D
L
-
Y
N
-
Q
K
I
N
--
E
--
N
K
I
E
--
L
--
E
E
I
L
R
----
D
I
I
Y
I
S
E
N
L
T
I
D
K
A
L
E
R
I
R
K
E
K
L
Q
L
A
I
V
V
--------
D
E
Y
G
G
T
S
G
V
V
T
I
E
D
I
L
E
E
I
V
-
G
E
I
---------------------------------------------------------------------------------------------
30
HHSearch
68.24
43%
-160
- C1 -
3LV9
1
?
A:
[18-146]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
F
E
E
K
K
I
R
E
I
M
V
P
R
T
D
M
V
C
I
Y
E
S
D
S
E
E
-
K
I
L
A
I
L
K
E
E
G
V
T
R
Y
P
V
C
R
K
N
-
K
-
D
D
I
L
G
F
V
H
I
R
D
L
-
Y
N
-
Q
K
I
N
--
E
--
N
K
I
E
--
L
--
E
E
I
L
R
----
D
I
I
Y
I
S
E
N
L
T
I
D
K
A
L
E
R
I
R
K
E
K
L
Q
L
A
I
V
V
--------
D
E
Y
G
G
T
S
G
V
V
T
I
E
D
I
L
E
E
I
V
-
G
E
----------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.60
36%
-201
- C1 -
3JTF
4
?
A:
[5-128]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
D
I
M
V
P
R
S
R
M
D
L
L
D
I
S
Q
P
L
P
-
Q
L
L
A
T
I
I
E
T
A
H
S
R
F
P
V
Y
E
D
D
-
R
-
D
N
I
I
G
I
L
L
A
K
D
L
-
L
R
--
Y
M
L
--
E
--
P
A
L
D
--
I
--
R
S
L
V
R
----
P
A
V
F
I
P
E
V
K
R
L
N
V
L
L
R
E
F
R
A
S
R
N
H
L
A
I
V
I
--------
D
E
-
G
G
I
S
G
L
V
T
M
E
D
V
L
E
Q
I
V
-
G
D
I
---------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.48
25%
-196
- C1 -
3LHH
1
?
A:
[43-165]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
S
S
L
M
V
P
R
S
D
I
V
F
L
D
L
N
L
P
L
D
-
A
N
L
R
T
V
M
Q
S
P
H
S
R
F
P
V
C
R
N
N
-
V
-
D
D
M
V
G
I
I
S
A
K
Q
L
-
L
S
-
E
S
I
A
--
G
--
E
R
L
E
--
L
--
V
D
L
V
K
----
N
C
N
F
V
P
N
S
L
S
G
M
E
L
L
E
H
F
R
T
T
G
S
Q
M
V
F
V
V
--------
D
E
Y
G
D
L
K
G
L
V
T
L
Q
D
M
M
D
A
L
T
-
G
E
----------------------------------------------------------------------------------------------
40
HHSearch
64.64
40%
-135
- C1 -
3NQR
1
CORC_SALTY
A:
[3-124]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
R
D
I
M
I
P
R
S
Q
M
I
T
L
K
R
N
Q
T
L
D
-
E
C
L
D
V
I
I
E
S
A
H
S
R
F
P
V
I
S
E
D
-
K
-
D
H
I
E
G
I
L
M
A
K
D
L
-
L
P
-
F
M
R
S
--
D
A-
E
A
F
S
--
M
--
D
K
V
L
R
----
T
A
V
V
V
P
E
S
K
R
V
D
R
M
L
K
E
F
R
S
Q
R
Y
H
M
A
I
V
I
--------
D
E
F
G
G
V
S
G
L
V
T
I
E
D
I
L
E
L
I
--------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.09
40%
-130
- C1 -
3NQR
1
CORC_SALTY
A:
[3-124]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
-
R
D
I
M
I
P
R
S
Q
M
I
T
L
K
R
N
Q
T
L
D
-
E
C
L
D
V
I
I
E
S
A
H
S
R
F
P
V
I
S
E
D
-
K
-
D
H
I
E
G
I
L
M
A
K
D
L
-
L
P
F
M
R
S
D
--
A
--
E
A
F
S
--
M
--
D
K
V
L
R
----
T
A
V
V
V
P
E
S
K
R
V
D
R
M
L
K
E
F
R
S
Q
R
Y
H
M
A
I
V
I
--------
D
E
F
G
G
V
S
G
L
V
T
I
E
D
I
L
E
L
I
--------------------------------------------------------------------------------------------------
42
HHSearch
61.94
38%
-87
- C1 -
3LFR
2
?
A:
[3-125]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
V
R
D
I
M
V
P
R
S
Q
M
I
S
I
K
A
T
Q
T
P
R
-
E
F
L
P
A
V
I
D
A
A
H
S
R
Y
P
V
I
G
E
S
-
H
-
D
D
V
L
G
V
L
L
A
K
D
L
-
L
P
-
L
I
L
K
--
A
DG
D
S
D
D
--
V
--
K
K
L
L
R
----
P
A
T
F
V
P
E
S
K
R
L
N
V
L
L
R
E
F
R
A
N
H
N
H
M
A
I
V
I
--------
D
E
Y
G
G
V
A
G
L
V
T
I
E
D
V
L
E
Q
I
--------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.75
37%
-85
- C1 -
3LFR
2
?
A:
[6-125]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
M
V
P
R
S
Q
M
I
S
I
K
A
T
Q
T
P
R
-
E
F
L
P
A
V
I
D
A
A
H
S
R
Y
P
V
I
G
E
S
-
H
-
D
D
V
L
G
V
L
L
A
K
D
L
-
L
P
-
L
I
L
K
AD
G
--
D
S
D
D
--
V
--
K
K
L
L
R
----
P
A
T
F
V
P
E
S
K
R
L
N
V
L
L
R
E
F
R
A
N
H
N
H
M
A
I
V
I
--------
D
E
Y
G
G
V
A
G
L
V
T
I
E
D
V
L
E
Q
I
--------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.42
27%
-158
- C1 -
3OCM
7
?
A:
[23-166]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
N
M
V
S
G
V
L
T
L
A
E
R
S
I
R
S
I
M
T
P
R
T
D
V
S
W
V
N
I
D
D
D
A
A
-
T
I
R
Q
Q
L
T
A
A
P
H
S
F
F
P
V
C
R
G
S
-
L
-
D
E
V
V
G
I
G
R
A
K
D
L
-
V
A
-
D
L
I
T
--
E
--
G
R
V
R
--
R
--
N
R
L
R
D
----
P
I
I
-
V
H
E
S
I
G
I
L
R
L
M
D
T
L
K
R
S
R
G
Q
L
V
L
V
A
--------
D
E
F
G
A
I
E
G
L
V
T
P
I
D
V
F
E
A
I
A
-
G
E
F
P
D
E
---
D
E
L
P
-----------------------------------------------------------------------------------
28
HHSearch
56.56
26%
-131
- C1 -
3LHH
1
?
A:
[43-167]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
S
S
L
M
V
P
R
S
D
I
V
F
L
D
L
N
L
P
L
D
-
A
N
L
R
T
V
M
Q
S
P
H
S
R
F
P
V
C
R
N
--
N
V
D
D
M
V
G
I
I
S
A
K
Q
L
-
L
S
-
E
S
I
A
--
G
--
E
R
L
E
--
L
--
V
D
L
V
K
----
N
C
N
F
V
P
N
S
L
S
G
M
E
L
L
E
H
F
R
T
T
G
S
Q
M
V
F
V
V
--------
D
E
Y
G
D
L
K
G
L
V
T
L
Q
D
M
M
D
A
L
T
-
G
E
F
F
--------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.54
28%
-131
- C1 -
3I8N
1
?
A:
[10-130]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
M
T
P
R
P
V
V
F
R
V
D
A
T
M
T
I
N
-
E
F
L
D
K
H
K
D
T
P
F
S
R
P
L
V
Y
S
E
Q
-
K
-
D
N
I
I
G
F
V
H
R
L
E
L
-
F
K
-
M
Q
Q
S
--
G
--
S
G
Q
K
Q-
L
--
G
A
V
M
R
----
P
I
Q
V
V
L
N
N
T
A
L
P
K
V
F
D
Q
M
M
T
H
R
L
Q
L
A
L
V
V
--------
D
E
Y
G
T
V
L
G
L
V
T
L
E
D
I
F
E
H
L
V
-
G
E
----------------------------------------------------------------------------------------------
20
PsiBlast_PDB
55.53
25%
-76
- C1 -
4IY4
-
CNNM2_HUMAN
A:
[429-580]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
E
L
N
I
I
Q
G
A
L
E
L
R
T
K
T
V
E
D
V
M
T
P
L
R
D
C
F
M
I
T
G
E
A
I
L
D
F
N
T
M
S
E
I
M
E
S
G
Y
T
R
I
P
V
F
E
G
E
-
R
-
S
N
I
V
D
L
L
F
V
K
D
L
A
F
V
-
D
P
D
D
--
C
--
T
P
L
K
T
I
T
--
K
F
Y
N
H
----
P
L
H
F
V
F
N
D
T
K
L
D
A
M
L
E
E
F
K
K
G
K
S
H
L
A
I
V
Q
R
V
N
NEGE
G
D
P
F
Y
E
V
L
G
I
V
I
L
E
D
V
I
E
E
I
I
K
S
E
----------------------------------------------------------------------------------------------
15
PsiBlast_PDB
53.56
29%
-59
- C1 -
4IY3
-
CNNM4_HUMAN
B:
[366-505]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
L
R
T
K
T
V
E
D
V
M
T
Q
L
Q
D
C
F
M
I
R
S
D
A
I
L
D
F
N
T
M
S
E
I
M
E
S
G
Y
T
R
I
P
V
F
E
D
E
-
Q
-
S
N
I
V
D
I
L
Y
V
K
D
L
A
F
V
-
D
P
D
D
--
C
--
T
P
L
K
------
T
I
T
R
F
YN
H
P
V
H
F
V
F
H
D
T
K
L
D
A
M
L
E
E
F
K
K
G
K
S
H
L
A
I
V
Q
K
V
N
NEG--
D
P
F
Y
E
V
L
G
L
V
T
L
E
D
V
I
E
E
I
I
K------------------------------------------------------------------------------------------------
31
HHSearch
52.95
32%
-101
- C- -
3OCO
-
?
A:
[211-346]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
F
M
Q
R
A
F
E
M
N
D
K
V
A
S
D
V
M
V
D
R
T
S
M
S
V
V
D
V
D
E
T
I
A
-
D
A
L
L
L
Y
L
E
E
Q
Y
S
R
F
P
V
T
A
D
N
D
K
-
D
K
I
I
G
Y
A
Y
N
Y
D
I
-
V
R
-
Q
A
R
I
--
D
--
D
K
A
K
--
I
--
S
T
I
M
R
----
D
I
V
S
V
P
E
N
M
K
V
P
D
V
M
E
E
M
S
A
H
R
V
P
M
A
I
V
I
--------
D
E
Y
G
G
T
S
G
I
I
T
D
K
D
V
Y
E
E
L
F
-
G
-----------------------------------------------------------------------------------------------
32
HHSearch
52.94
24%
-137
- C1 -
3OCM
7
?
A:
[18-164]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
G
V
E
E
R
N
M
V
S
G
V
L
T
L
A
E
R
S
I
R
S
I
M
T
P
R
T
D
V
S
W
V
N
I
D
D
D
A
A
-
T
I
R
Q
Q
L
T
A
A
P
H
S
F
F
P
V
C
R
G
S
-
L
-
D
E
V
V
G
I
G
R
A
K
D
L
-
V
A
-
D
L
I
T
--
E
----
G
R
--
V
--
R
R
N
R
L
R
---
D
P
I
I
V
H
E
S
I
G
I
L
R
L
M
D
T
L
K
R
S
R
G
Q
L
V
L
V
A
--------
D
E
F
G
A
I
E
G
L
V
T
P
I
D
V
F
E
A
I
A
-
G
E
F
P
D
E
D
E
----------------------------------------------------------------------------------------
18
PsiBlast_PDB
52.82
24%
-97
- C1 -
4P1G
1
A:
[3-149]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
N
I
I
Q
G
A
L
E
L
R
T
K
T
V
E
D
V
M
T
P
L
R
D
C
F
M
I
T
G
E
A
I
L
D
F
N
T
M
S
E
I
M
E
S
G
Y
T
R
I
P
V
F
E
G
E
-
R
-
S
N
I
V
D
L
L
F
V
K
D
L
A
F
V
-
D
P
D
D
--
C
--
T
P
L
K
--
T
I
T
K
F
Y
N
H
----
P
L
H
F
V
F
N
D
T
K
L
D
A
M
L
E
E
F
K
K
G
K
S
H
L
A
I
V
Q
R
V
N
NEGE
G
D
P
F
Y
E
V
L
G
I
V
T
L
E
D
V
I
E
E
I
I
-------------------------------------------------------------------------------------------------